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This paper takes the synergy between ideological work and student management in colleges and universities as an entry point, analyzes the intrinsic mechanism between the two, and gives the synergistic effect of parenting after the integration of the two. The synergistic mechanism between student management and ideological work is explored by mining students’ daily behavioral data, and after analyzing students’ daily behavioral data based on density-optimized clustering algorithm, risk warning detection of students’ academic situation is carried out by combining the improved LSTM model. The GCN network model is utilized to detect students’ psychological disorders. In order to verify the effectiveness of the method given in this paper for exploring the synergistic cultivation of ideological work and student management, quantitative analysis was carried out through the data of college students’ one-card. The results show that the movement data of college students are divided into 4 classes, of which the largest proportion of students is class cluster 4 is 44.59%, the risk prediction accuracy of the improved LSTM academic warning model is 0.731, and the GCN network model has a model loss value of about 0.25% after about 50 iterations when the threshold value is 0. Colleges and universities under the binary structure can narrow the value differences between students through data mining technology, and can help students remove psychological barriers, prompting the generation of a collaborative parenting mechanism between ideological work and student management in colleges and universities.

Background and purpose: Approximately 60% of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage, therefore cannot receive timely and effective treatment. At present, the sensitivity of serum biomarkers commonly used in the diagnosis of HCC is low. In this paper, through the differential expression analysis of plasma exosomal proteome, the candidate exosome protein markers which may be used in the diagnosis of HCC were identified. Methods: First, we performed shot-gun proteome mass spectrometry assays in the plasma exosomes from the discovery cohort [including 4 healthy control (HC) group and 4 HCC patients group], and identified differentially expressed proteins by qualitative and quantitative analyses. Then, we carried out enzyme-linked immunosorbent assay (ELISA) in plasma samples of an independent verification cohort [including 56 HCC patients group, 20 liver cirrhosis (LC) patients group and 48 HC group], and evaluated the diagnostic value of the candidate protein in HCC. Results: In the discovery cohort, we identified a total of 1 434 exosomal proteins, of which CD48 exhibited higher levels in HCC than in HC. We further verified in the validation cohort by ELISA that CD48 was markedly higher in HCC compared with LC and HC groups, with the area under receiver operating characteristic (ROC) curve (AUC) of 0.886. When combined with plasma alpha-fetoprotein (AFP), the AUC reached 0.970. Conclusion: The plasma exosomal CD48 protein can be used as a candidate diagnostic biomarker for HCC, and its combination with AFP may further improve the clinical diagnostic ability for HCC.

Objectives To evaluate the impact of microwave ablation (MWA) on pain relief, quality of life, mobility, and local tumour progression in adult patients with pelvic osteolytic bone metastasis and to test the safety of MWA. Methods This study retrospectively analysed the data from 20 patients with pelvic osteolytic metastases who received MWA combined with percutaneous osteoplasty (POP). The visual analogue scale (VAS), musculoskeletal tumour society system (MSTS), and Quality of Life Questionnaire-Bone Metastases 22 (QLQ-BM22) were used to evaluate the pain, limb function, and quality of life. The intraoperative and postoperative complications were recorded. The tumour recurrence and survival time were analysed during the follow-up period (range 3-26 months). Results All (n  = 20) MWA and POP operations were completed successfully. Four patients (20%; 95% CI, 6%-44%) had mild bone cement leakage from surrounding tissues, and there were no obvious symptoms or serious complications. There were significant differences in VAS, MSTS, and QLQ-BM22 scores before and after the operation (P  < .001). During the postoperative follow-up period, 9 patients died. The median survival time was 8 months (range 3-26 months; IQR: 4.5-13; 95% CI, 4.2-15.3 months), and the 1-year survival rate was 65% (13/20; 95% CI, 41%-85%). Tumour recurrence occurred in 4 cases (20%; 95% CI, 6%-44%) after the operation, and the median time of recurrence was 12 months (range 8-16 months; IQR: 8.25-12.75; 95% CI, 5.5-18.5 months). Conclusions MWA combined with POP is an effective and safe treatment for pelvic osteolytic metastases. It can significantly relieve local pain, reconstruct limb function, improve patients' quality of life, and effectively control local tumour progression. Advances in knowledge So far, the experience of using microwave in the treatment of pelvic metastases is still limited. MWA combined with POP in the treatment of pelvic osteolytic metastases can provide significant clinical benefits in acceptable low-risk minimally invasive situations and should be provided to patients with appropriate pelvic metastases in a multidisciplinary approach. [ABSTRACT FROM AUTHOR]