Search

Two new 1D coordination polymers, [Zn(3,3′-bpdc)(2,2′-bpy)] ( 1) and [Cd (3,3′-bpdc)(2,2′-bpy)] ( 2) [3,3′-Hbpdc = 3,3′-biphenyl dicarboxylic acid, 2,2′-bpy = 2,2′-bi pyridine], were rationally designed and synthesized with an identical strategy that employed 3,3′-Hbpdc as a bridge and 2,2′-bpy as a terminal ligand. As expected, the 3,3′-bpdc anions bridge Zn and Cd into a 1D zigzag single chain and 1D zigzag double chain, respectively. The 2,2′-bpy ligand serves as terminal components to decorate both sides of the 1D chain, which plays an important role in the self-assembly of the polymeric chain by providing potential supramolecular recognition sites for π-π stacking and C-H···π interactions. As a result, the two different zigzag chains in 1 and 2 are assembled into 2D wave-like layers via π-π stacking interactions. Furthermore, owing to the direction of the C-H···π interactions, the adjacent 2D layers embed into each other to form a 3D supramolecular framework. The thermogravimetric analysis and luminescent properties of 1 and 2 were also investigated. Graphical Abstract: Two new 3D supramolecular embedded-frameworks based on 1D different-shaped coordination polymeric chains, have rationally synthesized and characterized. Moreover, the thermal stability and photoluminescence property of compounds 1 and 2 were also investigated.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Abstract: A novel CdII-coordination framework [Cd(C4O4)(btb)(H2O)2]n (1) constructed by squaric acid (H2C4O4) and secondary N-donor spacer 1,4-bis(1,2,4-triazol-4-yl)butane (btb) is presented, which displays 2D→3D inclined polycatenate framework consisting of two of sets of equivalent 2D 44-sql layers and (4,6)-connected self-catenated H-bonding topology. In addition, the thermal stability and photo-luminescence property of 1 were also investigated. [Copyright &y& Elsevier]

Endogenous toxic components have become an important topic in the field of traditional Chinese medicines (TCMs). Since the endogenous toxic components in TCMs are often used as clinical effective components, the safety and effectiveness of endogenous toxic substances has become an important part of the research of TCMs. In this paper, the classification and evaluation criteria of toxic Chinese medicinal materials are described, and the analytical methods of endogenous components in TCMs are summarized and expounded base on with the techniques of chromatography, spectroscopy, immunoassay, and so on. On this basis, the problems in terms of endogenous toxic components are analyzed and discussed. This paper could provide ideas and methods for the evaluation of the validity and safety of TCMs containing endogenous toxic components., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)

With the extensive clinical application of Tripterygium wilfordii, there are many counterfeit products on the market. Traditional technology can not effectively identify the authenticity of the traditional Chinese medicine. Therefore, a strategy of accurate identification and quality evaluation of Tripterygium based on DNA barcode and chemical fingerprint spectrum was established. Based on DNA barcode technology, HMMer annotation method of hidden Markov model and K2P model were used to analyze genetic distance.BLAST1, nearest distance and phylogenetic tree (NJ-tree) methods were used to assess the identification efficiency of the ITS2 barcode. The fingerprint of 27 T. wilfordii was established by UPLC-PDA method, and the similarity of the fingerprint of different sources was evaluated. The main components of T. wilfordii were determined by LC-MS/MS. The results revealed that the intraspecific genetic distances of T. wilfordii were lower than the interspecific genetic distances between T. wilfordii and its adulterants. The results of similarity search showed that ITS2 sequence was used to identify T. wilfordii and its adulterants. The clustering of T. wilfordii and its adulterants was clear in the tree of NJ cluster, and 12 of 27 samples were identified as true T. wilfordii.The chemical fingerprint spectrum research indicates that the feature one region can distinguish the false product of tripterygium glycosides more intuitively. The cluster analysis of HCA-thermal map showed that the contents of six active components of T. wilfordii from different habitats were significantly different, which could be used to evaluate the quality of T. wilfordii. This paper is of guiding significance for the accurate identification and quality evaluation of Tripterygium medicinal plants., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)

To analyze the gE gene sequence of varicella-zoster virus (VZV) strains of different clades and subclades currently circulating in China. Eighteen skin lesion fluid swabs or skin scab pieces from patients with chickenpox or shingles were obtained from Beijing, Changchun, Lhasa and Urumqi between December 2010 and June 2011. The genotype of the virus strains was determined by a group of single nucleotide polymorphism (SNP) located in 15 ORFs, and the full-length gE genes of 18 strains representing all the clades in the study was amplified by PCR and sequenced. In addition to the synonymous mutations and non-synonymous mutations that were reported in the literature, there were 3 novel non-synonymous mutations (C56T, C1109T, C917A) and 4 new synonymous mutations (C54T, T1075C, T816C, G279A) found in the 8 strains analyzed. We found the VZV strains of clade 5 in Xinjiang for the first time,and the genotypes of some VZV strains circulating in Chagnchun could not be determined by the present methods. The analysis of gE gene sequences,revealed a novel non-synonymous mutations in the e1 and c1 epitopes, corresponding to the amino acid change of serine to tyrosine.

Objective: To study the risk factors and abusers' characteristics on childhood sexual abuses among female students to provide reference data for preventive measures on child sexual abuse., Methods: Annonymous questionnaire survey of 701 adult female students in a college about their personal experience on childhood sexual abuses, their home conditions and abusers' characteristics., Results: A total number of 701 female students were surveyed. 115 (22.11%) experienced non-physical contact sexual abuses before the age of 18, including 26 (3.71%) who suffered from attempted and 8 (1.14%) were forced with genital or anal sexual intercourse. 117 (16.69%) said they had suffered from sexual abuse before the age of 16. Most abusers were males (99.4%) and only a small percentage of them (3.2%) used violence. Most non-physical contact sexual abuses were from strangers (78.7%), while 71.3% of physical contact abuses were from acquaintances including 12.5% of them were teachers, 17.5% were neighbors and 21.3% were relatives. The risk factors of child sexual abuses were: frequent use of violence, bad hobbies and poor health conditions of parents, tight family relationships, and living in remarried families. Having well-educated fathers was a preventive factor., Conclusion: Studies on childhood sexual abuses among females revealed that the incidents were not rare, and family environment played an important role.