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691 results on '"Dubeau F"'

4. Interictal High‐Frequency Oscillations, Spikes, and Connectivity Profiles: a Fingerprint of Epileptogenic Brain Pathologies

Author

Sklenarova, B., primary, Zatloukalova, E., additional, Cimbalnik, J., additional, Klimes, P., additional, Dolezalova, I., additional, Pail, M., additional, Kocvarova, J., additional, Hendrych, M., additional, Hermanova, M., additional, Gotman, J., additional, Dubeau, F., additional, Hall, J., additional, Pana, R., additional, Frauscher, B., additional, and Brazdil, M., additional

Published
2023
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5. Diet Problems

Author

Joannopoulos, E., Dubeau, F., Dussault, J.-P., Pomar, C., Price, Camille C., Series editor, Zhu, Joe, Series editor, and Plà-Aragonés, Lluis M., editor

Published
2015
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12. A Difference Equation Model of Infectious Disease

Author

Shannon, A, Dubeau, F, Uysal, M, Özkan, E, Shannon, A, Dubeau, F, Uysal, M, and Özkan, E

Abstract

In the context of so much uncertainty with coronavirus variants and official mandate based on seemingly exaggerated predictions of gloom from epidemiologists, it is appropriate to consider a revised model of relative simplicity, because there can be dangers in developing models which endeavour to account for too many variables. Predictions and projections from any such models have to be in the context of relevant contingencies. The model presented here is based on relatively simple second order difference equations. The context here is as important as the content in that in many Western counties where the narrative currently seems more important than the truth, and the results of empirical science are valued more as a shield for politicians than a sword for protection of citizens

Published
2022

20. Patterns of hippocampal abnormalities in malformations of cortical development

Author

Montenegro, M.A., Kinay, D., Cendes, F., Bernasconi, A., Bernasconi, N., Coan, A.C., Li, L.M., Guerreiro, M.M., Guerreiro, C.A.M., Lopes-Cendes, I., Andermann, E., Dubeau, F., and Andermann, F.

Subjects
Cerebral cortex -- Abnormalities, Hippocampus (Brain) -- Research, Hippocampus (Brain) -- Abnormalities, Nervous system -- Abnormalities, Nervous system -- Physiological aspects, Nervous system -- Research, Health, Psychology and mental health
Published
2006

21. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain

Author

Gotman, J., Grova, C., Bagshaw, A., Kobayashi, E., Aghakhani, Y., and Dubeau, F.

Subjects
Epilepsy -- Research, Epilepsy -- Physiological aspects, Brain -- Research, Brain -- Physiological aspects, Neurosciences -- Research, Science and technology
Abstract

Our objective was to evaluate the brain regions showing increased and decreased metabolism in patients at the time of generalized bursts of epileptic discharges in order to understand their mechanism of generation and effect on brain function. By recording the electroencephalogram during the functional MRI, changes in the blood oxygenation level-dependent signal were obtained in response to epileptic discharges observed in the electroencephalogram of 15 patients with idiopathic generalized epilepsy. A group analysis was performed to determine the regions of positive (activation) and negative (deactivation) blood oxygenation level-dependent responses that were common to the patients. Activations were found bilaterally and symmetrically in the thalamus, mesial midfrontal region, insulae, and midline and bilateral cerebellum and on the borders of the lateral ventricles. Deactivations were bilateral and symmetrical in the anterior frontal and parietal regions and in the posterior cingulate gyri and were seen in the left posterior temporal region. Activations in thalamus and midfrontal regions confirm known involvement of these regions in the generation or spread of generalized epileptic discharges. Involvement of the insulae in generalized discharges had not previously been described. Cerebellar activation is not believed to reflect the generation of discharges. Deactivations in frontal and parietal regions remarkably followed the pattern of the default state of brain function. Thalamocortical activation and suspension of the default state may combine to cause the actual state of reduced responsiveness observed in patients during spike-and-wave discharges. This brief lapse of responsiveness may therefore not result only from the epileptic discharge but also from its effect on normal brain function. absence | epilepsy | thalamus

Published
2005

39. Letters to the Editor

Author

McMackin, D., Dubeau, F., Jones-Gotman, M., and Gotman, J.

Published
1999

43. P.048 Characterization of somatic mutations in mTOR pathway genes in focal cortical dysplasias

Author

Krochmalnek, E, primary, Accogli, A, additional, St-Onge, J, additional, Addour, N, additional, Dudley, R, additional, Myers, K, additional, Dubeau, F, additional, Karamchandani, J, additional, Farmer, J, additional, Atkinson, J, additional, Hall, J, additional, Poulin, C, additional, Rosenblatt, B, additional, Lapalme, J Lafond, additional, Albrecht, S, additional, Rivière, J, additional, and Srour, M, additional

Published
2019
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49. Familial mesial temporal lobe epilepsy associated with a deletion mutation in the chorea-acanthocytosis gene

Author

Andermann, E., Anna Jansen, Al-Asmi, A., Dobson-Stone, C., Monaco, A. P., Lang, A., Robert, F., Badhwar, A., Mercho, S., Dubeau, F., Danek, A., Andermann, F., and Public Health Care

Subjects
Chorea-acanthocytosis (CHAC), epilepsy
Abstract

Purpose: Chorea-acanthocytosis (CHAC) is an autosomal recessive disorder caused by mutations in VPS13A on chromosome 9q21, and characterised by neurodegeneration and acanthocytosis. Seizures are not uncommon in CHAC, but have not been well characterised. Methods: We studied 4 French-Canadian kindreds with CHAC. EEG, video-telemetry, MRI, blood smears, biochemical and genetic tests were performed. Results: 12 patients had clinical features of CHAC. 8 had epilepsy and this was the presenting symptom in 6. The epileptic aura consisted of déjà vu, fear, palpitations, vertigo, and visual hallucinations. EEG with video-telemetry confirmed ictal and interictal temporal epileptic abnormalities. In three families, patients were homozygous for a deletion of exons 70-73 of VPS13A, and exons 6-7 of GNA14. In family 4, two patients were compound heterozygotes for the deletion and a 4242+1G>T splicing mutation. Of all patients with the deletion 77% had seizures, as compared to 42% in the general CHAC population. 2 other patients in family 4 were homozygous for the splicing mutation and did not have seizures. Conclusion: Patients with CHAC have a tendency to develop temporal lobe epilepsy (TLE) and this may be the presenting feature. Treatment of epilepsy in CHAC patients represents a challenge, since seizures may be difficult to control and some anti-epileptic drugs may worsen the involuntary movements. The higher prevalence of epilepsy in the patients with the deletion suggests that this particular mutation may be more strongly associated with the epilepsy phenotype. CHAC represents a single gene disorder that can result in the TLE phenotype.

Published
2016

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