814 results on '"Duchen, Michael R."'
Search Results
2. PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington’s disease
3. NAD(P)H binding configurations revealed by time-resolved fluorescence and two-photon absorption
4. The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target
5. Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells.
6. Rewiring cell signalling pathways in pathogenic mtDNA mutations
7. Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation
8. Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats
9. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
10. Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown
11. Analysis of Organization and Activity of Mitochondrial Respiratory Chain Complexes in Primary Fibroblasts Using Blue Native PAGE
12. A Plate Reader-Based Measurement of the Cellular ROS Production Using Dihydroethidium and MitoSOX
13. Investigating Mitochondrial Ca2+ Dynamics in Isolated Mitochondria and Intact Cells: Application of Fluorescent Dyes and Genetic Reporters
14. Monitoring Mitochondrial Membrane Potential in Live Cells Using Time-Lapse Fluorescence Imaging
15. Assessing the Redox Status of Mitochondria Through the NADH/FAD2+ Ratio in Intact Cells
16. Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
17. The role of mitochondria in sepsis-induced cardiomyopathy
18. Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation
19. The ‘mitoflash’ probe cpYFP does not respond to superoxide
20. Targeting the proteostasis network in Huntington’s disease
21. Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets
22. Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
23. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification
24. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics
25. Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes
26. Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
27. AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
28. Transient Mitochondrial Depolarizations Reflect Focal Sarcoplasmic Reticular Calcium Release in Single Rat Cardiomyocytes
29. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
30. Investigating mitochondrial redox state using NADH and NADPH autofluorescence
31. PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
32. Mitochondrial dynamics and quality control in Huntington's disease
33. Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis
34. Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts
35. Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging
36. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
37. Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells
38. HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons
39. Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure
40. Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
41. Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia
42. Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health
43. Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy
44. PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1
45. The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α
46. Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke
47. Activated barrier crossing dynamics in the non-radiative decay of NADH and NADPH
48. Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
49. Functional Imaging of Mitochondria Within Cells
50. Cellular and molecular mechanisms of mitochondrial function
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