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12 results on '"Duff, C. M."'

2. Introduction and methods of the evidence-based guidelines for the diagnosis and management of autism spectrum disorder by the Italian National Institute of Health

Author

Morgano, G. P., Fulceri, F., Nardocci, F., Barbui, C., Ostuzzi, G., Papola, D., Fatta, L. M., Fauci, A. J., Coclite, D., Napoletano, A., De Crescenzo, F., D'Alo, G. L., Amato, L., Cinquini, M., Iannone, P., Schunemann, H. J., Scattoni, M. L., Arduino, M., Bellosio, C., Biasci, S., Buono, S., Cappa, C., Cordo, C., Di Tommaso, E., Duff, C. M., Felici, C., Massagli, A., Molteni, M., Reali, L., Tancredi, R., Valeri, G., Venturini, L., Zuddas, A., Andreoli, M., Bergamin, C., Bertelli, M., Catania, D., Cavagnola, R., Cirrincione, P., Corti, S., Crognale, M., Faggioli, R., Giogoli, A. M., Grittani, S., Keller, R., Pace, P., Politi, P., Starace, F., Valenti, M., Balduzzi, S., Basile, M., Cruciani, F., D'Amico, R., Davoli, M., Lorenzo, M. G., Minozzi, S., Mitrova, Z., Moschetti, I., Pistotti, V., Saulle, R., and Vecchi, S.

Subjects
Adult, Male, Evidence-based practice, Adolescent, Autism Spectrum Disorder, Psychological intervention, Guideline, Recommendations, lcsh:Computer applications to medicine. Medical informatics, 03 medical and health sciences, 0302 clinical medicine, Diagnosis, medicine, Humans, 030212 general & internal medicine, Patient Reported Outcome Measures, Autism Spectrum disorder, GRADE approach, Healthcare decision, Italian National Institute of health, Italian national guidelines system, Treatment, Grading (education), Child, Medical education, Evidence-Based Medicine, Research, Public Health, Environmental and Occupational Health, Conflict of interest, Stakeholder, Italy, Quality of Life, Practice Guidelines as Topic, General Medicine, Evidence-based medicine, medicine.disease, Autism spectrum disorder, ComputingMilieux_COMPUTERSANDSOCIETY, lcsh:R858-859.7, Psychology, 030217 neurology & neurosurgery
Abstract

Background Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that affects communication and behavior with a prevalence of approximately 1% worldwide. Health outcomes of interventions for ASD are largely Participant Reported Outcomes (PROs). Specific guidelines can help support the best care for people with ASD to optimize these health outcomes but they have to adhere to standards for their development to be trustworthy. Objective The goal of this article is to describe the new methodological standards of the Italian National Institute of Health and novel aspects of this guideline development process. This article will serve as a reference standard for future guideline development in the Italian setting. Methods We applied the new standards of the Italian National Institute of Health to the two guidelines on diagnosis and management of children/adolescents and adults with ASD, with a focus on the scoping, panel composition, management of conflict of interest, generation and prioritization of research questions, early stakeholders’ involvement, and PROs. Recommendations are based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence-to-Decision frameworks. Results Following a public application process, the ISS established two multidisciplinary panels including people with ASD and/or their caregivers. Seventy-nine research questions were identified as potentially relevant for the guideline on children and adolescents with ASD and 31 for the one on adults with ASD. Questions deemed to have the highest priority were selected for inclusion in the guidelines. Other stakeholders valued their early involvement in the process which will largely focus on PROs. The panels then successfully piloted the development of recommendations using the methodological standards and process set by the ISS with a focus on PROs. Conclusions In this article, we describe the development of practice guidelines that focus on PROs for the diagnosis and management of ASD based on novel methods for question prioritization and stakeholder involvement. The recommendations allow for the adoption or adaptation to international settings.

Published
2020

12. Does pheromone biology of Lambdina athasaria and L. pellucidaria contribute to their reproductive isolation?

Author

Duff CM, Gries G, Mori K, Shirai Y, Seki M, Takikawa H, Sheng T, Slessor KN, Gries R, Maier CT, and Ferguson DC

Subjects
Animals, Ecology, Electrophysiology, Flight, Animal, Lepidoptera classification, Male, Random Allocation, Seasons, Sex Attractants chemical synthesis, Species Specificity, Statistics, Nonparametric, Stereoisomerism, Tsuga parasitology, Lepidoptera physiology, Sex Attractants physiology
Abstract

Recently, 7-methylheptadecane and 7,11-dimethylheptadecane have been reported as sex pheromone components of both spring hemlock looper (SHL), Lambdina athasaria, and pitch pine looper (PPL), Lambdina pellucidaria. Our objective was to test the hypothesis that SHL and PPL are reproductively isolated, in part, through species specificity in: (1) absolute configuration of pheromone components, (2) diel periodicity of pheromonal communication, and/or (3) seasonal flight period. In coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of stereoselectively synthesized (7S)- and (7R)-7-methylheptadecane [7S; 7R] as well as (7S,11S)-, (7R,11R)-, and (meso-7,11)-7,11-dimethylheptadecane [7S,11S; 7R,11R; meso-7,11], only 7S and meso-7,11 elicited responses by male SHL and PPL antennae. In field experiments, male SHL and PPL were attracted only to lures containing 7S plus meso-7,11. In hourly recordings of trap-captured males, SHL and PPL in their respective habitats were trapped between 24:00 and 03:00 hr. Capture of both SHL and PPL in pheromone-baited traps throughout June indicated overlapping seasonal flight periods. These findings of identical absolute configuration of pheromoal components, diel periodicity of pheromonal communication, and overlap of seasonal flight periods support synonymy of SHL and PPL. Finite taxonomic classification of PPL and SHL must await careful assessment of further criteria, such as morphometrics, molecular comparisons and ecological analyses.

Published
2001
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