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1,105 results on '"Dufouil , Carole"'

1. X‐chromosome-wide association study for Alzheimer’s disease

Author

Le Borgne, Julie, Gomez, Lissette, Heikkinen, Sami, Amin, Najaf, Ahmad, Shahzad, Choi, Seung Hoan, Bis, Joshua, Grenier-Boley, Benjamin, Rodriguez, Omar Garcia, Kleineidam, Luca, Young, Juan, Tripathi, Kumar Parijat, Wang, Lily, Varma, Achintya, Campos-Martin, Rafael, van der Lee, Sven, Damotte, Vincent, de Rojas, Itziar, Palmal, Sagnik, Lipton, Richard, Reiman, Eric, McKee, Ann, De Jager, Philip, Bush, William, Small, Scott, Levey, Allan, Saykin, Andrew, Foroud, Tatiana, Albert, Marilyn, Hyman, Bradley, Petersen, Ronald, Younkin, Steven, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Schneider, Julie, Henderson, Victor, Roberson, Erik, DeCarli, Charles, LaFerla, Frank, Brewer, James, Swerdlow, Russell, Van Eldik, Linda, Hamilton-Nelson, Kara, Paulson, Henry, Naj, Adam, Lopez, Oscar, Chui, Helena, Crane, Paul, Grabowski, Thomas, Kukull, Walter, Asthana, Sanjay, Craft, Suzanne, Strittmatter, Stephen, Cruchaga, Carlos, Leverenz, James, Goate, Alison, Kamboh, M. Ilyas, George-Hyslop, Peter St, Valladares, Otto, Kuzma, Amanda, Cantwell, Laura, Riemenschneider, Matthias, Morris, John, Slifer, Susan, Dalmasso, Carolina, Castillo, Atahualpa, Küçükali, Fahri, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Deckert, Jürgen, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina-Porcel, Laura, Düzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Dols-Icardo, Oriol, Moreno, Fermin, Pérez-Tur, Jordi, Bullido, María J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M., Piñol-Ripoll, Gerard, García-Alberca, Jose María, Royo, Jose Luís, Rodriguez-Rodriguez, Eloy, Soininen, Hilkka, de Mendonça, Alexandre, Mehrabian, Shima, Traykov, Latchezar, Hort, Jakub, Vyhnalek, Martin, Thomassen, Jesper Qvist, Pijnenburg, Yolande A. L., Holstege, Henne, van Swieten, John, Ramakers, Inez, Verhey, Frans, Scheltens, Philip, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Deleuze, Jean-François, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stéphanie, Grünblatt, Edna, Popp, Julius, Ghidoni, Roberta, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Spallazzi, Marco, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Bossù, Paola, Masullo, Carlo, Rossi, Giacomina, Jessen, Frank, Fernandez, Victoria, Kehoe, Patrick Gavin, Frikke-Schmidt, Ruth, Tsolaki, Magda, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Haines, Jonathan, Farrer, Lindsay, Mayeux, Richard, Wang, Li-San, Sims, Rebecca, DeStefano, Anita, Schellenberg, Gerard D., Seshadri, Sudha, Amouyel, Philippe, Williams, Julie, van der Flier, Wiesje, Ramirez, Alfredo, Pericak-Vance, Margaret, Andreassen, Ole A., Van Duijn, Cornelia, Hiltunen, Mikko, Ruiz, Agustín, Dupuis, Josée, Martin, Eden, Lambert, Jean-Charles, Kunkle, Brian, and Bellenguez, Céline

Published
2024
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2. Genetic risk factors underlying white matter hyperintensities and cortical atrophy

Author

Patel, Yash, Shin, Jean, Sliz, Eeva, Tang, Ariana, Mishra, Aniket, Xia, Rui, Hofer, Edith, Rajula, Hema Sekhar Reddy, Wang, Ruiqi, Beyer, Frauke, Horn, Katrin, Riedl, Max, Yu, Jing, Völzke, Henry, Bülow, Robin, Völker, Uwe, Frenzel, Stefan, Wittfeld, Katharina, Van der Auwera, Sandra, Mosley, Thomas H., Bouteloup, Vincent, Lambert, Jean-Charles, Chêne, Geneviève, Dufouil, Carole, Tzourio, Christophe, Mangin, Jean-François, Gottesman, Rebecca F., Fornage, Myriam, Schmidt, Reinhold, Yang, Qiong, Witte, Veronica, Scholz, Markus, Loeffler, Markus, Roshchupkin, Gennady V., Ikram, M. Arfan, Grabe, Hans J., Seshadri, Sudha, Debette, Stephanie, Paus, Tomas, and Pausova, Zdenka

Published
2024
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4. Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration

Author

Ahmad, Shahzad, Imtiaz, Mohammad Aslam, Mishra, Aniket, Wang, Ruiqi, Herrera-Rivero, Marisol, Bis, Joshua C., Fornage, Myriam, Roshchupkin, Gennady, Hofer, Edith, Logue, Mark, Longstreth, Jr, W. T., Xia, Rui, Bouteloup, Vincent, Mosley, Thomas, Launer, Lenore J., Khalil, Michael, Kuhle, Jens, Rissman, Robert A., Chene, Genevieve, Dufouil, Carole, Djoussé, Luc, Lyons, Michael J., Mukamal, Kenneth J., Kremen, William S., Franz, Carol E., Schmidt, Reinhold, Debette, Stephanie, Breteler, Monique M. B., Berger, Klaus, Yang, Qiong, Seshadri, Sudha, Aziz, N. Ahmad, Ghanbari, Mohsen, and Ikram, M. Arfan

Published
2024
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5. Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer's disease and related dementia

Author

Lespinasse, Jérémie, Dufouil, Carole, Proust-Lima, Cécile, and group, the MEMENTO study

Subjects
Statistics - Methodology
Abstract

Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are inappropriate and time-to-clinical diagnosis is available on small subsamples of participants with short follow-up durations prior to diagnosis. One solution to circumvent this challenge is to define the disease time as a latent variable. Methods: We developed a multivariate mixed model approach that realigns individual trajectories into the latent disease time to describe disease progression. Our methodology exploits the clinical diagnosis information as a partially observed and approximate reference to guide the estimation of the latent disease time. The model estimation was carried out in the Bayesian Framework using Stan. We applied the methodology to 2186 participants of the MEMENTO study with 5-year follow-up. Repeated measures of 12 ADRD markers stemmed from cerebrospinal fluid (CSF), brain imaging and cognitive tests were analyzed. Result: The estimated latent disease time spanned over twenty years before the clinical diagnosis. Considering the profile of a woman aged 70 with a high level of education and APOE4 carrier (the main genetic risk factor for ADRD), CSF markers of tau proteins accumulation preceded markers of brain atrophy by 5 years and cognitive decline by 10 years. We observed that individual characteristics could substantially modify the sequence and timing of these changes. Conclusion: Our disease progression model does not only realign trajectories into the most homogeneous way. It accounts for the inherent residual inter-individual variability in dementia progression to describe the long-term changes according to the years preceding clinical diagnosis, and to provide clinically meaningful information on the sequence of events.

Published
2023
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7. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Author

Mishra, Aniket, Duplaà, Cécile, Vojinovic, Dina, Suzuki, Hideaki, Sargurupremraj, Muralidharan, Zilhão, Nuno R, Li, Shuo, Bartz, Traci M, Jian, Xueqiu, Zhao, Wei, Hofer, Edith, Wittfeld, Katharina, Harris, Sarah E, van der Auwera-Palitschka, Sandra, Luciano, Michelle, Bis, Joshua C, Adams, Hieab HH, Satizabal, Claudia L, Gottesman, Rebecca F, Gampawar, Piyush G, Bülow, Robin, Weiss, Stefan, Yu, Miao, Bastin, Mark E, Lopez, Oscar L, Vernooij, Meike W, Beiser, Alexa S, Völker, Uwe, Kacprowski, Tim, Soumare, Aicha, Smith, Jennifer A, Knopman, David S, Morris, Zoe, Zhu, Yicheng, Rotter, Jerome I, Dufouil, Carole, Hernández, Maria Valdés, Maniega, Susana Muñoz, Lathrop, Mark, Boerwinkle, Erik, Schmidt, Reinhold, Ihara, Masafumi, Mazoyer, Bernard, Yang, Qiong, Joutel, Anne, Tournier-Lasserve, Elizabeth, Launer, Lenore J, Deary, Ian J, Mosley, Thomas H, Amouyel, Philippe, DeCarli, Charles S, Psaty, Bruce M, Tzourio, Christophe, Kardia, Sharon LR, Grabe, Hans J, Teumer, Alexander, van Duijn, Cornelia M, Schmidt, Helena, Wardlaw, Joanna M, Ikram, M Arfan, Fornage, Myriam, Gudnason, Vilmundur, Seshadri, Sudha, Matthews, Paul M, Longstreth, William T, Couffinhal, Thierry, and Debette, Stephanie

Subjects
Epidemiology, Health Sciences, Neurosciences, Cerebrovascular, Neurodegenerative, Brain Disorders, Human Genome, Aging, Alzheimer's Disease Related Dementias (ADRD), Stroke, Vascular Cognitive Impairment/Dementia, Dementia, Acquired Cognitive Impairment, Minority Health, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Genetics, 2.1 Biological and endogenous factors, Cardiovascular, Neurological, Animals, Brain Ischemia, Cerebral Small Vessel Diseases, Endothelial Cells, Genome-Wide Association Study, Mice, cerebral small vessel disease, endothelial cells, GWAS, TRIM47, whole-exome association study, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited. We report a genome-wide association study and a whole-exome association study on a composite extreme phenotype of cerebral small vessel disease derived from its most common MRI features: white matter hyperintensities and lacunes. Seventeen population-based cohorts of older persons with MRI measurements and genome-wide genotyping (n = 41 326), whole-exome sequencing (n = 15 965), or exome chip (n = 5249) data contributed 13 776 and 7079 extreme small vessel disease samples for the genome-wide association study and whole-exome association study, respectively. The genome-wide association study identified significant association of common variants in 11 loci with extreme small vessel disease, of which the chr12q24.11 locus was not previously reported to be associated with any MRI marker of cerebral small vessel disease. The whole-exome association study identified significant associations of extreme small vessel disease with common variants in the 5' UTR region of EFEMP1 (chr2p16.1) and one probably damaging common missense variant in TRIM47 (chr17q25.1). Mendelian randomization supports the causal association of extensive small vessel disease severity with increased risk of stroke and Alzheimer's disease. Combined evidence from summary-based Mendelian randomization studies and profiling of human loss-of-function allele carriers showed an inverse relation between TRIM47 expression in the brain and blood vessels and extensive small vessel disease severity. We observed significant enrichment of Trim47 in isolated brain vessel preparations compared to total brain fraction in mice, in line with the literature showing Trim47 enrichment in brain endothelial cells at single cell level. Functional evaluation of TRIM47 by small interfering RNAs-mediated knockdown in human brain endothelial cells showed increased endothelial permeability, an important hallmark of cerebral small vessel disease pathology. Overall, our comprehensive gene-mapping study and preliminary functional evaluation suggests a putative role of TRIM47 in the pathophysiology of cerebral small vessel disease, making it an important candidate for extensive in vivo explorations and future translational work.

Published
2022

8. Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

Author

Sarnowski, Chloé, Ghanbari, Mohsen, Bis, Joshua C, Logue, Mark, Fornage, Myriam, Mishra, Aniket, Ahmad, Shahzad, Beiser, Alexa S, Boerwinkle, Eric, Bouteloup, Vincent, Chouraki, Vincent, Cupples, L Adrienne, Damotte, Vincent, DeCarli, Charles S, DeStefano, Anita L, Djoussé, Luc, Fohner, Alison E, Franz, Carol E, Kautz, Tiffany F, Lambert, Jean-Charles, Lyons, Michael J, Mosley, Thomas H, Mukamal, Kenneth J, Pase, Matthew P, Portilla Fernandez, Eliana C, Rissman, Robert A, Satizabal, Claudia L, Vasan, Ramachandran S, Yaqub, Amber, Debette, Stephanie, Dufouil, Carole, Launer, Lenore J, Kremen, William S, Longstreth, William T, Ikram, M Arfan, and Seshadri, Sudha

Subjects
Biological Sciences, Genetics, Dementia, Human Genome, Neurodegenerative, Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Brain Disorders, Neurosciences, Aging, Acquired Cognitive Impairment, Minority Health, Health Disparities, 2.1 Biological and endogenous factors, Stroke, Neurological, Black or African American, Alzheimer Disease, Exome, Genome-Wide Association Study, Humans, Tauopathies, Biological sciences, Biomedical and clinical sciences
Abstract

Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P

Published
2022

11. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Franco-Macías, Emilio, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Frank-García, Ana, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., and Ruiz, Agustín

Published
2023
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12. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

Author

Ali, Muhammad, Archer, Derek B., Gorijala, Priyanka, Western, Daniel, Timsina, Jigyasha, Fernández, Maria V., Wang, Ting-Chen, Satizabal, Claudia L., Yang, Qiong, Beiser, Alexa S., Wang, Ruiqi, Chen, Gengsheng, Gordon, Brian, Benzinger, Tammie L. S., Xiong, Chengjie, Morris, John C., Bateman, Randall J., Karch, Celeste M., McDade, Eric, Goate, Alison, Seshadri, Sudha, Mayeux, Richard P., Sperling, Reisa A., Buckley, Rachel F., Johnson, Keith A., Won, Hong-Hee, Jung, Sang-Hyuk, Kim, Hang-Rai, Seo, Sang Won, Kim, Hee Jin, Mormino, Elizabeth, Laws, Simon M., Fan, Kang-Hsien, Kamboh, M. Ilyas, Vemuri, Prashanthi, Ramanan, Vijay K., Yang, Hyun-Sik, Wenzel, Allen, Rajula, Hema Sekhar Reddy, Mishra, Aniket, Dufouil, Carole, Debette, Stephanie, Lopez, Oscar L., DeKosky, Steven T., Tao, Feifei, Nagle, Michael W., Hohman, Timothy J., Sung, Yun Ju, Dumitrescu, Logan, and Cruchaga, Carlos

Published
2023
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13. Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial

Author

Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Andrieu, Sandrine, Cantet, Christelle, Morin, Christophe, Abellan Van Kan, Gabor, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Cerda, Sandrine, Cuffi, Marie-Noëlle, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Li Yung Tong, Michael, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristel, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, Misbah El Idrissi, Samira, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Perret, Bertrand, Vinel, Claire, Caspar-Bauguil, Sylvie, Olivier-Abbal, Pascale, Coley, Nicola, Zetterberg, Henrik, Ashton, Nicholas J, and Blennow, Kaj

Published
2024
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15. Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Author

Jansen, Iris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Dalmasso, Maria Carolina, Grenier-Boley, Benjamin, Zettergren, Anna, Mishra, Aniket, Ali, Muhammad, Andrade, Victor, Bellenguez, Céline, Kleineidam, Luca, Küçükali, Fahri, Sung, Yun Ju, Tesí, Niccolo, Vromen, Ellen M., Wightman, Douglas P., Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Amouyel, Philippe, Athanasiu, Lavinia, Bahrami, Shahram, Bailly, Henri, Belbin, Olivia, Bergh, Sverre, Bertram, Lars, Biessels, Geert Jan, Blennow, Kaj, Blesa, Rafael, Boada, Mercè, Boland, Anne, Buerger, Katharina, Carracedo, Ángel, Cervera-Carles, Laura, Chene, Geneviève, Claassen, Jurgen A. H. R., Debette, Stephanie, Deleuze, Jean-Francois, de Deyn, Peter Paul, Diehl-Schmid, Janine, Djurovic, Srdjan, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Düzel, Emrah, Fladby, Tormod, Fortea, Juan, Frölich, Lutz, García-González, Pablo, Garcia-Martinez, Maria, Giegling, Ina, Goldhardt, Oliver, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernández, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Kern, Silke, Knapskog, Anne-Brita, Koivisto, Anne M., Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleó, Alberto, de Munain, Adolfo López, Lopez-Garcia, Sara, Maier, Wolfgang, Marquié, Marta, Mol, Merel O., Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Nöthen, Markus M., Orellana, Adelina, Pålhaugen, Lene, Papma, Janne M., Pasquier, Florence, Perneczky, Robert, Peters, Oliver, Pijnenburg, Yolande A. L., Popp, Julius, Posthuma, Danielle, Pozueta, Ana, Priller, Josef, Puerta, Raquel, Quintela, Inés, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Rujescu, Dan, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Schneider, Anja, Selbæk, Geir, Selnes, Per, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tárraga, Lluís, Teipel, Stefan, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Van Dongen, Jasper, van Swieten, John C., Vandenberghe, Rik, Vidal, Jean-Sébastien, Visser, Pieter J., Vogelgsang, Jonathan, Waern, Margda, Wagner, Michael, Wiltfang, Jens, Wittens, Mandy M. J., Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M., Bjerke, Maria, Engelborghs, Sebastiaan, Jessen, Frank, Teunissen, Charlotte E., Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Andreassen, Ole A., Clarimón, Jordi, Sleegers, Kristel, Ruiz, Agustín, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles, and van der Flier, Wiesje

Published
2022
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16. Neural correlates of episodic memory in the Memento cohort

Author

Epelbaum, Stéphane, Bouteloup, Vincent, Mangin, Jean, La Corte, Valentina, Migliaccio, Raffaela, Bertin, Hugo, Habert, Marie O., Fischer, Clara, Azouani, Chabha, Fillon, Ludovic, Chupin, Marie, Vellas, Bruno, Pasquier, Florence, Dartigues, Jean, Blanc, Frédéric, Gabelle, Audrey, Ceccaldi, Mathieu, Krolak-Salmon, Pierre, Hugon, Jacques, Hanon, Olivier, Rouaud, Olivier, David, Renaud, Chêne, Geneviève, Dubois, Bruno, and Dufouil, Carole

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

IntroductionThe free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.MethodsWe investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose--positron emission tomography evaluations.ResultsEncoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions.DiscussionThe neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.

Published
2018
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17. Neuropsychological Test Performance and MRI Markers of Dementia Risk

Author

Walter, Stefan, Dufouil, Carole, Gross, Alden L, Jones, Richard N, Mungas, Dan, Filshtein, Teresa J, Manly, Jennifer J, Arpawong, Thalida E, and Glymour, M Maria

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Clinical Research, Acquired Cognitive Impairment, Aging, Brain Disorders, Neurodegenerative, Digestive Diseases, Biomedical Imaging, Alzheimer's Disease, Dementia, Behavioral and Social Science, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Neurological, Quality Education, Aged, Biomarkers, Cognition, Cohort Studies, Educational Status, Female, France, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status and Dementia Tests, Neuropsychological Tests, White Matter, cognitive function, cognitive reserve, education, bias, interaction, MMSE, MRI, Cognitive Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

BackgroundTo use neuropsychological assessments for studying the underlying disease processes contributing to dementia, it is crucial that they correspond to magnetic resonance imaging (MRI)-based measures of dementia, regardless of educational level.MethodsFrench 3-City Dijon MRI study cohort members (n=1782) with assessments of white matter lesion volume (WMLV), hippocampal volume (HCV), and cerebrospinal fluid volume (CSFV), and 6 waves of neuropsychological assessments over 11 years, including Mini-Mental State Examination (MMSE), plus 5 other tests combined using a Z-score or item-response theory (IRT-cognition) comprised the study cohort. We evaluated, testing interactions, whether education modified associations of MRI markers with intercept or rate of change of MMSE, Z-score composite, or IRT-cognition.ResultsIn linear models, education modified the associations of WMLV and CSFV with MMSE and CSFV and Z-score composite. In mixed models, education modified the associations of WMLV and CSFV with level of MMSE and the association of HCV with slope of MMSE. Education also modified the association with CSFV and slope of Z-score composite decline. There was no evidence that education modified associations between MRI measures and level or slope of IRT-cognition.ConclusionsLongitudinal analysis of correctly scaled neuropsychological assessments may provide unbiased proxies for MRI-based measures of dementia risk.

Published
2019

20. New insights into the genetic etiology of Alzheimer’s disease and related dementias

Author

Bellenguez, Céline, Küçükali, Fahri, Jansen, Iris E., Kleineidam, Luca, Moreno-Grau, Sonia, Amin, Najaf, Naj, Adam C., Campos-Martin, Rafael, Grenier-Boley, Benjamin, Andrade, Victor, Holmans, Peter A., Boland, Anne, Damotte, Vincent, van der Lee, Sven J., Costa, Marcos R., Kuulasmaa, Teemu, Yang, Qiong, de Rojas, Itziar, Bis, Joshua C., Yaqub, Amber, Prokic, Ivana, Chapuis, Julien, Ahmad, Shahzad, Giedraitis, Vilmantas, Aarsland, Dag, Garcia-Gonzalez, Pablo, Abdelnour, Carla, Alarcón-Martín, Emilio, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Álvarez, Victoria, Armstrong, Nicola J., Tsolaki, Anthoula, Antúnez, Carmen, Appollonio, Ildebrando, Arcaro, Marina, Archetti, Silvana, Pastor, Alfonso Arias, Arosio, Beatrice, Athanasiu, Lavinia, Bailly, Henri, Banaj, Nerisa, Baquero, Miquel, Barral, Sandra, Beiser, Alexa, Pastor, Ana Belén, Below, Jennifer E., Benchek, Penelope, Benussi, Luisa, Berr, Claudine, Besse, Céline, Bessi, Valentina, Binetti, Giuliano, Bizarro, Alessandra, Blesa, Rafael, Boada, Mercè, Boerwinkle, Eric, Borroni, Barbara, Boschi, Silvia, Bossù, Paola, Bråthen, Geir, Bressler, Jan, Bresner, Catherine, Brodaty, Henry, Brookes, Keeley J., Brusco, Luis Ignacio, Buiza-Rueda, Dolores, Bûrger, Katharina, Burholt, Vanessa, Bush, William S., Calero, Miguel, Cantwell, Laura B., Chene, Geneviève, Chung, Jaeyoon, Cuccaro, Michael L., Carracedo, Ángel, Cecchetti, Roberta, Cervera-Carles, Laura, Charbonnier, Camille, Chen, Hung-Hsin, Chillotti, Caterina, Ciccone, Simona, Claassen, Jurgen A. H. R., Clark, Christopher, Conti, Elisa, Corma-Gómez, Anaïs, Costantini, Emanuele, Custodero, Carlo, Daian, Delphine, Dalmasso, Maria Carolina, Daniele, Antonio, Dardiotis, Efthimios, Dartigues, Jean-François, de Deyn, Peter Paul, de Paiva Lopes, Katia, de Witte, Lot D., Debette, Stéphanie, Deckert, Jürgen, del Ser, Teodoro, Denning, Nicola, DeStefano, Anita, Dichgans, Martin, Diehl-Schmid, Janine, Diez-Fairen, Mónica, Rossi, Paolo Dionigi, Djurovic, Srdjan, Duron, Emmanuelle, Düzel, Emrah, Dufouil, Carole, Eiriksdottir, Gudny, Engelborghs, Sebastiaan, Escott-Price, Valentina, Espinosa, Ana, Ewers, Michael, Faber, Kelley M., Fabrizio, Tagliavini, Nielsen, Sune Fallgaard, Fardo, David W., Farotti, Lucia, Fenoglio, Chiara, Fernández-Fuertes, Marta, Ferrari, Raffaele, Ferreira, Catarina B., Ferri, Evelyn, Fin, Bertrand, Fischer, Peter, Fladby, Tormod, Fließbach, Klaus, Fongang, Bernard, Fornage, Myriam, Fortea, Juan, Foroud, Tatiana M., Fostinelli, Silvia, Fox, Nick C., Franco-Macías, Emlio, Bullido, María J., Frank-García, Ana, Froelich, Lutz, Fulton-Howard, Brian, Galimberti, Daniela, García-Alberca, Jose Maria, García-González, Pablo, Garcia-Madrona, Sebastian, Garcia-Ribas, Guillermo, Ghidoni, Roberta, Giegling, Ina, Giorgio, Giaccone, Goate, Alison M., Goldhardt, Oliver, Gomez-Fonseca, Duber, González-Pérez, Antonio, Graff, Caroline, Grande, Giulia, Green, Emma, Grimmer, Timo, Grünblatt, Edna, Grunin, Michelle, Gudnason, Vilmundur, Guetta-Baranes, Tamar, Haapasalo, Annakaisa, Hadjigeorgiou, Georgios, Haines, Jonathan L., Hamilton-Nelson, Kara L., Hampel, Harald, Hanon, Olivier, Hardy, John, Hartmann, Annette M., Hausner, Lucrezia, Harwood, Janet, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernández, Isabel, Herrmann, Martin J., Hoffmann, Per, Holmes, Clive, Holstege, Henne, Vilas, Raquel Huerto, Hulsman, Marc, Humphrey, Jack, Biessels, Geert Jan, Jian, Xueqiu, Johansson, Charlotte, Jun, Gyungah R., Kastumata, Yuriko, Kauwe, John, Kehoe, Patrick G., Kilander, Lena, Ståhlbom, Anne Kinhult, Kivipelto, Miia, Koivisto, Anne, Kornhuber, Johannes, Kosmidis, Mary H., Kukull, Walter A., Kuksa, Pavel P., Kunkle, Brian W., Kuzma, Amanda B., Lage, Carmen, Laukka, Erika J., Launer, Lenore, Lauria, Alessandra, Lee, Chien-Yueh, Lehtisalo, Jenni, Lerch, Ondrej, Lleó, Alberto, Longstreth, Jr, William, Lopez, Oscar, de Munain, Adolfo Lopez, Love, Seth, Löwemark, Malin, Luckcuck, Lauren, Lunetta, Kathryn L., Ma, Yiyi, Macías, Juan, MacLeod, Catherine A., Maier, Wolfgang, Mangialasche, Francesca, Spallazzi, Marco, Marquié, Marta, Marshall, Rachel, Martin, Eden R., Montes, Angel Martín, Rodríguez, Carmen Martínez, Masullo, Carlo, Mayeux, Richard, Mead, Simon, Mecocci, Patrizia, Medina, Miguel, Meggy, Alun, Mehrabian, Shima, Mendoza, Silvia, Menéndez-González, Manuel, Mir, Pablo, Moebus, Susanne, Mol, Merel, Molina-Porcel, Laura, Montrreal, Laura, Morelli, Laura, Moreno, Fermin, Morgan, Kevin, Mosley, Thomas, Nöthen, Markus M., Muchnik, Carolina, Mukherjee, Shubhabrata, Nacmias, Benedetta, Ngandu, Tiia, Nicolas, Gael, Nordestgaard, Børge G., Olaso, Robert, Orellana, Adelina, Orsini, Michela, Ortega, Gemma, Padovani, Alessandro, Paolo, Caffarra, Papenberg, Goran, Parnetti, Lucilla, Pasquier, Florence, Pastor, Pau, Peloso, Gina, Pérez-Cordón, Alba, Pérez-Tur, Jordi, Pericard, Pierre, Peters, Oliver, Pijnenburg, Yolande A. L., Pineda, Juan A., Piñol-Ripoll, Gerard, Pisanu, Claudia, Polak, Thomas, Popp, Julius, Posthuma, Danielle, Priller, Josef, Puerta, Raquel, Quenez, Olivier, Quintela, Inés, Thomassen, Jesper Qvist, Rábano, Alberto, Rainero, Innocenzo, Rajabli, Farid, Ramakers, Inez, Real, Luis M., Reinders, Marcel J. T., Reitz, Christiane, Reyes-Dumeyer, Dolly, Ridge, Perry, Riedel-Heller, Steffi, Riederer, Peter, Roberto, Natalia, Rodriguez-Rodriguez, Eloy, Rongve, Arvid, Allende, Irene Rosas, Rosende-Roca, Maitée, Royo, Jose Luis, Rubino, Elisa, Rujescu, Dan, Sáez, María Eugenia, Sakka, Paraskevi, Saltvedt, Ingvild, Sanabria, Ángela, Sánchez-Arjona, María Bernal, Sanchez-Garcia, Florentino, Juan, Pascual Sánchez, Sánchez-Valle, Raquel, Sando, Sigrid B., Sarnowski, Chloé, Satizabal, Claudia L., Scamosci, Michela, Scarmeas, Nikolaos, Scarpini, Elio, Scheltens, Philip, Scherbaum, Norbert, Scherer, Martin, Schmid, Matthias, Schneider, Anja, Schott, Jonathan M., Selbæk, Geir, Seripa, Davide, Serrano, Manuel, Sha, Jin, Shadrin, Alexey A., Skrobot, Olivia, Slifer, Susan, Snijders, Gijsje J. L., Soininen, Hilkka, Solfrizzi, Vincenzo, Solomon, Alina, Song, Yeunjoo, Sorbi, Sandro, Sotolongo-Grau, Oscar, Spalletta, Gianfranco, Spottke, Annika, Squassina, Alessio, Stordal, Eystein, Tartan, Juan Pablo, Tárraga, Lluís, Tesí, Niccolo, Thalamuthu, Anbupalam, Thomas, Tegos, Tosto, Giuseppe, Traykov, Latchezar, Tremolizzo, Lucio, Tybjærg-Hansen, Anne, Uitterlinden, Andre, Ullgren, Abbe, Ulstein, Ingun, Valero, Sergi, Valladares, Otto, Broeckhoven, Christine Van, Vance, Jeffery, Vardarajan, Badri N., van der Lugt, Aad, Dongen, Jasper Van, van Rooij, Jeroen, van Swieten, John, Vandenberghe, Rik, Verhey, Frans, Vidal, Jean-Sébastien, Vogelgsang, Jonathan, Vyhnalek, Martin, Wagner, Michael, Wallon, David, Wang, Li-San, Wang, Ruiqi, Weinhold, Leonie, Wiltfang, Jens, Windle, Gill, Woods, Bob, Yannakoulia, Mary, Zare, Habil, Zhao, Yi, Zhang, Xiaoling, Zhu, Congcong, Zulaica, Miren, Farrer, Lindsay A., Psaty, Bruce M., Ghanbari, Mohsen, Raj, Towfique, Sachdev, Perminder, Mather, Karen, Jessen, Frank, Ikram, M. Arfan, de Mendonça, Alexandre, Hort, Jakub, Tsolaki, Magda, Pericak-Vance, Margaret A., Amouyel, Philippe, Williams, Julie, Frikke-Schmidt, Ruth, Clarimon, Jordi, Deleuze, Jean-François, Rossi, Giacomina, Seshadri, Sudha, Andreassen, Ole A., Ingelsson, Martin, Hiltunen, Mikko, Sleegers, Kristel, Schellenberg, Gerard D., van Duijn, Cornelia M., Sims, Rebecca, van der Flier, Wiesje M., Ruiz, Agustín, Ramirez, Alfredo, and Lambert, Jean-Charles

Published
2022
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21. Will biomarker-based diagnosis of Alzheimer’s disease maximize scientific progress? Evaluating proposed diagnostic criteria

Author

Glymour, Medellena Maria, Brickman, Adam Mark, Kivimaki, Mika, Mayeda, Elizabeth Rose, Chêne, Geneviève, Dufouil, Carole, and Manly, Jennifer Jaie

Subjects
Epidemiology, Health Sciences, Aging, Acquired Cognitive Impairment, Alzheimer's Disease, Brain Disorders, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Dementia, Prevention, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Alzheimer Disease, Biomarkers, Humans, Reproducibility of Results, Alzheimer's disease, Diagnostic criteria, Validity, Reliability, Alzheimer’s disease, Public Health and Health Services
Abstract

A recently published framework for the diagnosis of Alzheimer's disease (AD) in research studies would allow diagnosis on the sole basis of two biomarkers (β-amyloid and pathologic tau), even in people with no objective or subjective memory or cognitive changes. This revision will have substantial implications for future Alzheimer's research, and the changes should be rigorously evaluated before widespread adoption. We propose three principles for evaluating any revision to diagnostic frameworks for AD: (1) does the revision improve the validity of the diagnosis; (2) does the revision improve the reliability or reduce the expense of the diagnosis; and (3) will the revision foster innovative and rigorous research across populations. The new diagnostic framework is unlikely to achieve any of these goals. Instead, it has the potential to handicap future researchers, and slow progress towards identifying effective strategies to prevent or treat AD.

Published
2018

22. Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

Author

Grasset, Leslie, Proust-Lima, Cécile, Mangin, Jean-François, Habert, Marie-Odile, Dubois, Bruno, Paquet, Claire, Hanon, Olivier, Gabelle, Audrey, Ceccaldi, Mathieu, Annweiler, Cédric, David, Renaud, Jonveaux, Therese, Belin, Catherine, Julian, Adrien, Rouch-Leroyer, Isabelle, Pariente, Jérémie, Locatelli, Maxime, Chupin, Marie, Chêne, Geneviève, and Dufouil, Carole

Published
2022
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23. Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort

Author

Blanc, Frederic, Bouteloup, Vincent, Paquet, Claire, Chupin, Marie, Pasquier, Florence, Gabelle, Audrey, Ceccaldi, Mathieu, de Sousa, Paulo Loureiro, Krolak-Salmon, Pierre, David, Renaud, Fischer, Clara, Dartigues, Jean-François, Wallon, David, Moreaud, Olivier, Sauvée, Mathilde, Belin, Catherine, Harston, Sandrine, Botzung, Anne, Albasser, Timothée, Demuynck, Catherine, Namer, Izzie, Habert, Marie-Odile, Kremer, Stéphane, Bousiges, Olivier, Verny, Marc, Muller, Candice, Philippi, Nathalie, Chene, Geneviève, Cretin, Benjamin, Mangin, Jean-François, and Dufouil, Carole

Published
2022
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24. Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort

Author

Planche, Vincent, Bouteloup, Vincent, Pellegrin, Isabelle, Mangin, Jean-Francois, Dubois, Bruno, Ousset, Pierre-Jean, Pasquier, Florence, Blanc, Frederic, Paquet, Claire, Hanon, Olivier, Bennys, Karim, Ceccaldi, Mathieu, Annweiler, Cédric, Krolak-Salmon, Pierre, Godefroy, Olivier, Wallon, David, Sauvee, Mathilde, Boutoleau-Bretonnière, Claire, Bourdel-Marchasson, Isabelle, Jalenques, Isabelle, Chene, Genevieve, and Dufouil, Carole

Published
2022
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25. Meal-related difficulties and weight loss in older people: Longitudinal data from MAPT study

Author

Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Andrieu, Sandrine, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Marie-Noëlle-Cuffi, Sandrine Cerda, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Tong, Michael Li Yung, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristelle, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, Olivier-Abbal, Pascale, Coley, Nicola, Soriano, Gaëlle, De Souto Barreto, Philippe, and Virecoulon Giudici, Kelly

Published
2020
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26. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia

Author

Sargurupremraj, Muralidharan, primary, Soumaré, Aicha, additional, Bis, Joshua C., additional, Surakka, Ida, additional, Jürgenson, Tuuli, additional, Joly, Pierre, additional, Knol, Maria J., additional, Wang, Ruiqi, additional, Yang, Qiong, additional, Satizabal, Claudia L., additional, Gudjonsson, Alexander, additional, Mishra, Aniket, additional, Bouteloup, Vincent, additional, Phuah, Chia-Ling, additional, van Duijn, Cornelia M., additional, Cruchaga, Carlos, additional, Dufouil, Carole, additional, Chêne, Geneviève, additional, Lopez, Oscar L., additional, Psaty, Bruce M., additional, Tzourio, Christophe, additional, Amouyel, Philippe, additional, Adams, Hieab H., additional, Jacqmin-Gadda, Hélène, additional, Ikram, Mohammad Arfan, additional, Gudnason, Vilmundur, additional, Milani, Lili, additional, Winsvold, Bendik S., additional, Hveem, Kristian, additional, Matthews, Paul M., additional, Longstreth, W. T., additional, Seshadri, Sudha, additional, Launer, Lenore J., additional, and Debette, Stéphanie, additional

Published
2024
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28. The Dementias Platform UK (DPUK) Data Portal

Author

Bauermeister, Sarah, Orton, Christopher, Thompson, Simon, Barker, Roger A., Bauermeister, Joshua R., Ben-Shlomo, Yoav, Brayne, Carol, Burn, David, Campbell, Archie, Calvin, Catherine, Chandran, Siddharthan, Chaturvedi, Nishi, Chêne, Geneviève, Chessell, Iain P., Corbett, Anne, Davis, Daniel H. J., Denis, Mike, Dufouil, Carole, Elliott, Paul, Fox, Nick, Hill, Derek, Hofer, Scott M., Hu, Michele T., Jindra, Christoph, Kee, Frank, Kim, Chi-Hun, Kim, Changsoo, Kivimaki, Mika, Koychev, Ivan, Lawson, Rachael A., Linden, Gerry J., Lyons, Ronan A., Mackay, Clare, Matthews, Paul M., McGuiness, Bernadette, Middleton, Lefkos, Moody, Catherine, Moore, Katrina, Na, Duk L., O’Brien, John T., Ourselin, Sebastien, Paranjothy, Shantini, Park, Ki-Soo, Porteous, David J., Richards, Marcus, Ritchie, Craig W., Rohrer, Jonathan D., Rossor, Martin N., Rowe, James B., Scahill, Rachael, Schnier, Christian, Schott, Jonathan M., Seo, Sang W., South, Matthew, Steptoe, Matthew, Tabrizi, Sarah J., Tales, Andrea, Tillin, Therese, Timpson, Nicholas J., Toga, Arthur W., Visser, Pieter-Jelle, Wade-Martins, Richard, Wilkinson, Tim, Williams, Julie, Wong, Andrew, and Gallacher, John E. J.

Published
2020

31. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia

Author

Sargurupremraj, Muralidharan, Soumaré, Aicha, Bis, Joshua C., Surakka, Ida, Jürgenson, Tuuli, Joly, Pierre, Knol, Maria J., Wang, Ruiqi, Yang, Qiong, Satizabal, Claudia L., Gudjonsson, Alexander, Mishra, Aniket, Bouteloup, Vincent, Phuah, Chia Ling, van Duijn, Cornelia M., Cruchaga, Carlos, Dufouil, Carole, Chêne, Geneviève, Lopez, Oscar L., Psaty, Bruce M., Tzourio, Christophe, Amouyel, Philippe, Adams, Hieab H., Jacqmin-Gadda, Hélène, Ikram, Mohammad Arfan, Gudnason, Vilmundur, Milani, Lili, Winsvold, Bendik S., Hveem, Kristian, Matthews, Paul M., Longstreth, W. T., Seshadri, Sudha, Launer, Lenore J., Debette, Stéphanie, Sargurupremraj, Muralidharan, Soumaré, Aicha, Bis, Joshua C., Surakka, Ida, Jürgenson, Tuuli, Joly, Pierre, Knol, Maria J., Wang, Ruiqi, Yang, Qiong, Satizabal, Claudia L., Gudjonsson, Alexander, Mishra, Aniket, Bouteloup, Vincent, Phuah, Chia Ling, van Duijn, Cornelia M., Cruchaga, Carlos, Dufouil, Carole, Chêne, Geneviève, Lopez, Oscar L., Psaty, Bruce M., Tzourio, Christophe, Amouyel, Philippe, Adams, Hieab H., Jacqmin-Gadda, Hélène, Ikram, Mohammad Arfan, Gudnason, Vilmundur, Milani, Lili, Winsvold, Bendik S., Hveem, Kristian, Matthews, Paul M., Longstreth, W. T., Seshadri, Sudha, Launer, Lenore J., and Debette, Stéphanie

Abstract

Importance: Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain. Objective: To investigate the causal association between white matter hyperintensity (WMH) burden, clinical stroke, blood pressure (BP), and dementia risk, while accounting for potential epidemiologic biases. Design, Setting, and Participants: This study first examined the association of genetically determined WMH burden, stroke, and BP levels with Alzheimer disease (AD) in a 2-sample mendelian randomization (2SMR) framework. Second, using population-based studies (1979-2018) with prospective dementia surveillance, the genetic association of WMH, stroke, and BP with incident all-cause dementia was examined. Data analysis was performed from July 26, 2020, through July 24, 2022. Exposures: Genetically determined WMH burden and BP levels, as well as genetic liability to stroke derived from genome-wide association studies (GWASs) in European ancestry populations. Main Outcomes and Measures: The association of genetic instruments for WMH, stroke, and BP with dementia was studied using GWASs of AD (defined clinically and additionally meta-analyzed including both clinically diagnosed AD and AD defined based on parental history [AD-meta]) for 2SMR and incident all-cause dementia for longitudinal analyses. Results: In 2SMR (summary statistics-based) analyses using AD GWASs with up to 75 024 AD cases (mean [SD] age at AD onset, 75.5 [4.4] years; 56.9% women), larger WMH burden showed evidence for a causal association with increased risk of AD (odds ratio [OR], 1.43; 95% CI, 1.10-1.86; P = .007, per unit increase in WMH risk alleles) and AD-meta (OR, 1.19; 95% CI, 1.06-1.34; P = .008), after accounting for pulse pressure for the former. Blood pressure traits showed evidence for a protective association with AD, with evidence for confounding by shared genetic instruments. In the longitudinal (individual-level data

Published
2024

32. White Matter Lesion Progression

Author

Hofer, Edith, Cavalieri, Margherita, Bis, Joshua C, DeCarli, Charles, Fornage, Myriam, Sigurdsson, Sigurdur, Srikanth, Velandai, Trompet, Stella, Verhaaren, Benjamin FJ, Wolf, Christiane, Yang, Qiong, Adams, Hieab HH, Amouyel, Philippe, Beiser, Alexa, Buckley, Brendan M, Callisaya, Michele, Chauhan, Ganesh, de Craen, Anton JM, Dufouil, Carole, van Duijn, Cornelia M, Ford, Ian, Freudenberger, Paul, Gottesman, Rebecca F, Gudnason, Vilmundur, Heiss, Gerardo, Hofman, Albert, Lumley, Thomas, Martinez, Oliver, Mazoyer, Bernard, Moran, Chris, Niessen, Wiro J, Phan, Thanh, Psaty, Bruce M, Satizabal, Claudia L, Sattar, Naveed, Schilling, Sabrina, Shibata, Dean K, Slagboom, P Eline, Smith, Albert, Stott, David J, Taylor, Kent D, Thomson, Russell, Töglhofer, Anna M, Tzourio, Christophe, van Buchem, Mark, Wang, Jing, Westendorp, Rudi GJ, Windham, B Gwen, Vernooij, Meike W, Zijdenbos, Alex, Beare, Richard, Debette, Stéphanie, Ikram, M Arfan, Jukema, J Wouter, Launer, Lenore J, Longstreth, WT, Mosley, Thomas H, Seshadri, Sudha, Schmidt, Helena, and Schmidt, Reinhold

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Prevention, Genetics, Cardiovascular, Cerebrovascular, Clinical Research, Human Genome, Aging, 2.1 Biological and endogenous factors, Stroke, Adult, Aged, Cohort Studies, Disease Progression, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Leukoencephalopathies, Male, Middle Aged, Prospective Studies, White Matter, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, aging, biological factors, cerebral small vessel diseases, magnetic resonance imaging, white matter lesions, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeWhite matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.MethodsHeritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies.ResultsA total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5%, and no single-nucleotide polymorphisms achieved genome-wide significance (P

Published
2015

33. Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Author

Verhaaren, Benjamin FJ, Debette, Stéphanie, Bis, Joshua C, Smith, Jennifer A, Ikram, M Kamran, Adams, Hieab H, Beecham, Ashley H, Rajan, Kumar B, Lopez, Lorna M, Barral, Sandra, van Buchem, Mark A, van der Grond, Jeroen, Smith, Albert V, Hegenscheid, Katrin, Aggarwal, Neelum T, de Andrade, Mariza, Atkinson, Elizabeth J, Beekman, Marian, Beiser, Alexa S, Blanton, Susan H, Boerwinkle, Eric, Brickman, Adam M, Bryan, R Nick, Chauhan, Ganesh, Chen, Christopher PLH, Chouraki, Vincent, de Craen, Anton JM, Crivello, Fabrice, Deary, Ian J, Deelen, Joris, De Jager, Philip L, Dufouil, Carole, Elkind, Mitchell SV, Evans, Denis A, Freudenberger, Paul, Gottesman, Rebecca F, Guðnason, Vilmundur, Habes, Mohamad, Heckbert, Susan R, Heiss, Gerardo, Hilal, Saima, Hofer, Edith, Hofman, Albert, Ibrahim-Verbaas, Carla A, Knopman, David S, Lewis, Cora E, Liao, Jiemin, Liewald, David CM, Luciano, Michelle, van der Lugt, Aad, Martinez, Oliver O, Mayeux, Richard, Mazoyer, Bernard, Nalls, Mike, Nauck, Matthias, Niessen, Wiro J, Oostra, Ben A, Psaty, Bruce M, Rice, Kenneth M, Rotter, Jerome I, von Sarnowski, Bettina, Schmidt, Helena, Schreiner, Pamela J, Schuur, Maaike, Sidney, Stephen S, Sigurdsson, Sigurdur, Slagboom, P Eline, Stott, David JM, van Swieten, John C, Teumer, Alexander, Töglhofer, Anna Maria, Traylor, Matthew, Trompet, Stella, Turner, Stephen T, Tzourio, Christophe, Uh, Hae-Won, Uitterlinden, André G, Vernooij, Meike W, Wang, Jing J, Wong, Tien Y, Wardlaw, Joanna M, Windham, B Gwen, Wittfeld, Katharina, Wolf, Christiane, Wright, Clinton B, Yang, Qiong, Zhao, Wei, Zijdenbos, Alex, Jukema, J Wouter, Sacco, Ralph L, Kardia, Sharon LR, Amouyel, Philippe, Mosley, Thomas H, Longstreth, WT, DeCarli, Charles C, van Duijn, Cornelia M, Schmidt, Reinhold, Launer, Lenore J, Grabe, Hans J, and Seshadri, Sudha S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Acquired Cognitive Impairment, Stroke, Neurosciences, Aging, Dementia, Genetics, Neurodegenerative, Cerebrovascular, Human Genome, Prevention, Clinical Research, Brain Disorders, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Vascular Cognitive Impairment/Dementia, 2.1 Biological and endogenous factors, Aged, Aged, 80 and over, Chromosomes, Human, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Middle Aged, Models, Genetic, Racial Groups, White Matter, cerebral small vessel diseases, cerebrovascular disorders, genome-wide association study, hypertension, leukoencephalopathies, polymorphisms, single nucleotide, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies.Methods and resultsWe included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (n=17 936), African (n=1943), Hispanic (n=795), and Asian (n=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each single-nucleotide polymorphism and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (P=2.7×10(-19)) and identified novel loci on chr10q24 (P=1.6×10(-9)) and chr2p21 (P=4.4×10(-8)). In the multiethnic meta-analysis, we identified 2 additional loci, on chr1q22 (P=2.0×10(-8)) and chr2p16 (P=1.5×10(-8)). The novel loci contained genes that have been implicated in Alzheimer disease (chr2p21 and chr10q24), intracerebral hemorrhage (chr1q22), neuroinflammatory diseases (chr2p21), and glioma (chr10q24 and chr2p16).ConclusionsWe identified 4 novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of WMH in addition to previously proposed ischemic mechanisms.

Published
2015

34. Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Montrreal, Laura, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Franco-Macías, Emilio, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Frank-García, Ana, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-Madrona, Sebastián, García-González, Pablo, Alarcón-Martín, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Pérez-Cordón, Alba, Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Martín Montes, Angel, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Abdelnour, Carla, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., and Ruiz, Agustín

Published
2021
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35. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Author

Richard, Edo, van Gool, Pim, van Charante, Eric Moll, Beishuizen, Cathrien, Jongstra, Susan, van Middelaar, Tessa, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Soininen, Hilkka, Ngandu, Tiia, Barbera, Mariagnese, Kivipelto, Miia, Mangiasche, Francesca, Andrieu, Sandrine, Coley, Nicola, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, Brayne, Carol, Solomon, Alina, Laatikainen, Tiina, Strandberg, Timo, Tuomilehto, Jaakko, Antikainen, Riitta, Lindström, Jaana, Lehtisalo, Jenni, Havulinna, Satu, Rauramaa, Rainer, Hänninen, Tuomo, Bäckman, Lars, Stigsdotter-Neely, Anna, Jula, Antti, Peltonen, Markku, Levälahti, Esko, Grönholm, Marko, Hemiö, Katri, Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Cerda, Sandrine, Marie-Noëlle-Cuffi, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Yung Tong, Michael Li, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristelle, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, and Olivier-Abbal, Pascale

Published
2019
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36. Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial

Author

Coley, Nicola, primary, Zetterberg, Henrik, additional, Cantet, Christelle, additional, Guyonnet, Sophie, additional, Ashton, Nicholas J, additional, Vellas, Bruno, additional, Blennow, Kaj, additional, Andrieu, Sandrine, additional, Carrié, Isabelle, additional, Brigitte, Lauréane, additional, Faisant, Catherine, additional, Lala, Françoise, additional, Delrieu, Julien, additional, Villars, Hélène, additional, Combrouze, Emeline, additional, Badufle, Carole, additional, Zueras, Audrey, additional, Morin, Christophe, additional, Abellan Van Kan, Gabor, additional, Dupuy, Charlotte, additional, Rolland, Yves, additional, Caillaud, Céline, additional, Ousset, Pierre-Jean, additional, Willis, Sherry, additional, Belleville, Sylvie, additional, Gilbert, Brigitte, additional, Fontaine, Francine, additional, Dartigues, Jean-François, additional, Marcet, Isabelle, additional, Delva, Fleur, additional, Foubert, Alexandra, additional, Cerda, Sandrine, additional, Cuffi, Marie-Noëlle, additional, Costes, Corinne, additional, Rouaud, Olivier, additional, Manckoundia, Patrick, additional, Quipourt, Valérie, additional, Marilier, Sophie, additional, Franon, Evelyne, additional, Bories, Lawrence, additional, Pader, Marie-Laure, additional, Basset, Marie-France, additional, Lapoujade, Bruno, additional, Faure, Valérie, additional, Li Yung Tong, Michael, additional, Malick-Loiseau, Christine, additional, Cazaban-Campistron, Evelyne, additional, Desclaux, Françoise, additional, Blatge, Colette, additional, Dantoine, Thierry, additional, Laubarie-Mouret, Cécile, additional, Saulnier, Isabelle, additional, Clément, Jean-Pierre, additional, Picat, Marie-Agnès, additional, Bernard-Bourzeix, Laurence, additional, Willebois, Stéphanie, additional, Désormais, Iléana, additional, Cardinaud, Noëlle, additional, Bonnefoy, Marc, additional, Livet, Pierre, additional, Rebaudet, Pascale, additional, Gédéon, Claire, additional, Burdet, Catherine, additional, Terracol, Flavien, additional, Pesce, Alain, additional, Roth, Stéphanie, additional, Chaillou, Sylvie, additional, Louchart, Sandrine, additional, Sudres, Kristel, additional, Lebrun, Nicolas, additional, Barro-Belaygues, Nadège, additional, Touchon, Jacques, additional, Bennys, Karim, additional, Gabelle, Audrey, additional, Romano, Aurélia, additional, Touati, Lynda, additional, Marelli, Cécilia, additional, Pays, Cécile, additional, Robert, Philippe, additional, Le Duff, Franck, additional, Gervais, Claire, additional, Gonfrier, Sébastien, additional, Gasnier, Yannick, additional, Bordes, Serge, additional, Begorre, Danièle, additional, Carpuat, Christian, additional, Khales, Khaled, additional, Lefebvre, Jean-François, additional, Misbah El Idrissi, Samira, additional, Skolil, Pierre, additional, Salles, Jean-Pierre, additional, Dufouil, Carole, additional, Lehéricy, Stéphane, additional, Chupin, Marie, additional, Mangin, Jean-François, additional, Bouhayia, Ali, additional, Allard, Michèle, additional, Ricolfi, Frédéric, additional, Dubois, Dominique, additional, Bonceour Martel, Marie Paule, additional, Cotton, François, additional, Bonafé, Alain, additional, Chanalet, Stéphane, additional, Hugon, Françoise, additional, Bonneville, Fabrice, additional, Cognard, Christophe, additional, Chollet, François, additional, Payoux, Pierre, additional, Voisin, Thierry, additional, Peiffer, Sophie, additional, Hitzel, Anne, additional, Zanca, Michel, additional, Monteil, Jacques, additional, Darcourt, Jacques, additional, Molinier, Laurent, additional, Derumeaux, Hélène, additional, Costa, Nadège, additional, Perret, Bertrand, additional, Vinel, Claire, additional, Caspar-Bauguil, Sylvie, additional, Olivier-Abbal, Pascale, additional, and Coley, Nicola, additional

Published
2024
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37. Genome‐wide Association Study Meta‐analysis of Neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration

Author

Ahmad, Shahzad, primary, Imtiaz, Mohammed Aslam, additional, Mishra, Aniket, additional, Wang, Ruiqi, additional, Rivero, Marisol Herrera‐, additional, Bis, Joshua C, additional, Fornage, Myriam, additional, Roshchupkin, Gennady V., additional, Hofer, Edith, additional, Logue, Mark W., additional, Longstreth, W.T., additional, Xia, Rui, additional, Bouteloup, Vincent, additional, Mosley, Thomas H., additional, Launer, Lenore J J., additional, Khalil, Michael, additional, Kuhle, Jens, additional, Rissman, Robert A, additional, Chêne, Geneviève, additional, Dufouil, Carole, additional, Djoussé, Luc, additional, Lyons, Michael J., additional, Mukamal, Kenneth J, additional, Stone, William Seth, additional, Franz, Carol E, additional, Schmidt, Reinhold, additional, Debette, Stéphanie, additional, Breteler, Monique M.B., additional, Berger, Klaus, additional, Yang, Qiong, additional, Seshadri, Sudha, additional, Aziz, N. Ahmad, additional, Ghanbari, Mohsen, additional, and Ikram, M. Arfan, additional

Published
2023
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39. Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study

Author

Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Andrieu, Sandrine, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Marie-Noëlle-Cuffi, Sandrine Cerda, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Yung Tong, Michael Li, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristel, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, Olivier-Abbal, Pascale, de Souto Barreto, Philipe, Goisser, Sabine, and Soriano, Gaëlle

Published
2018
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42. Brain MRI markers and dropout in a longitudinal study of cognitive aging

Author

Glymour, M Maria, Chêne, Geneviève, Tzourio, Christophe, and Dufouil, Carole

Subjects
Acquired Cognitive Impairment, Neurosciences, Basic Behavioral and Social Science, Clinical Research, Dementia, Aging, Brain Disorders, Neurodegenerative, Biomedical Imaging, Behavioral and Social Science, Neurological, Aged, Biomarkers, Brain, Cognition Disorders, Female, France, Humans, Interview, Psychological, Leukoencephalopathies, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Patient Dropouts, Predictive Value of Tests, Prospective Studies, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveLongitudinal studies of dementia rely on the assumption that individuals who drop out are comparable to those who remain in the study, adjusting for measured covariates. Existing methods to handle dropouts account for differences based on past health and cognitive measures. We assess whether such adjustments fully account for differences in future dementia risk.MethodsAmong Three-City Study participants in Dijon, France, with 1 (n = 1,633) or 2 (n = 1,168) brain MRI scans, we tested whether white matter lesion volume (WMLV), hippocampal volume, or brain CSF volume predicted dropout ("unable to contact" or "refused interview") in repeated-measures logistic regression with up to 4 follow-ups (average 3.5 waves). Using linear regression, we also estimated differences in MRI volumes and MRI changes by subsequent dropout status and estimated plausible ranges for selective attrition bias based on these associations. Models were adjusted for demographic, health, and cognitive score covariates.ResultsBaseline greater WMLV predicted increased odds of dropping out (adjusted odds ratio = 1.71; 95% confidence interval [CI] 1.20-2.43). Among participants with 2 MRI scans, individuals who subsequently dropped out had significantly worse declines in hippocampal volume (-0.30 SD difference; 95% CI -0.43 to -0.17) between the first and second MRI scans.ConclusionsHigher future dementia risk, indicated by worse past brain MRI findings, predicted future study dropout. Adjustment for selective attrition, based on MRI markers when available, may help reduce bias in estimates of dementia incidence and improve research on dementia risk factors. MRI findings may also help prospectively identify cohort members at elevated risk of attrition.

Published
2012

43. Transferability of a European-derived Alzheimer’s Disease Genetic Risk Score across Multi-Ancestry Populations

Author

Nicolas, Aude, primary, Grenier-Boley, Benjamin, additional, Sherva, Richard, additional, Kim, Yoontae, additional, Kikuchi, Masataka, additional, de Rojas, Itziar, additional, Dalmasso, Carolina, additional, Zhou, Xiaopu, additional, Guen, Yann Le, additional, Arboleda-Bustos, Carlos E, additional, Camargos Bicalho, Maria Aparecida, additional, Guerchet, Maëlenn, additional, van der Lee, Sven, additional, Goss, Monica, additional, Castillo, Atahualpa, additional, Bellenguez, Céline, additional, Küçükali, Fahri, additional, Satizabal Barrera, Claudia, additional, Fongang, Bernard, additional, yang, Qiong, additional, Peters, Oliver, additional, Schneider, Anja, additional, Dichgans, Martin, additional, Rujescu, Dan, additional, Scherbaum, Norbert, additional, Deckert, Jürgen, additional, Riedel-Heller, Steffi, additional, Hausner, Lucrezia, additional, Molina Porcel, Laura, additional, Düzel, Emrah, additional, Grimmer, Timo, additional, Wiltfang, Jens, additional, Heilmann-Heimbach, Stefanie, additional, Moebus, Susanne, additional, Tegos, Thomas, additional, Scarmeas, Nikolaos, additional, Dols-Icardo, Oriol, additional, Moreno, Fermin, additional, Pérez-Tur, Jordi, additional, Bullido, María J., additional, Pastor, Pau, additional, Sánchez-Valle, Raquel, additional, Álvarez, Victoria, additional, Cao, Han, additional, Ip, Nancy Y., additional, Fu, Amy K. Y., additional, Ip, Fanny C. F., additional, Olivar, Natividad, additional, Muchnik, Carolina, additional, Cuesta, Carolina, additional, Campanelli, Lorenzo, additional, Solis, Patricia, additional, Politis, Daniel Gustavo, additional, Kochen, Silvia, additional, Brusco, Luis Ignacio, additional, Boada, Mercè, additional, García-González, Pablo, additional, Puerta, Raquel, additional, Mir, Pablo, additional, Real, Luis M, additional, Piñol-Ripoll, Gerard, additional, María García-Alberca, Jose, additional, Luís Royo, Jose, additional, Rodriguez-Rodriguez, Eloy, additional, Soininen, Hilkka, additional, Heikkinen, Sami, additional, de Mendonça, Alexandre, additional, Mehrabian, Shima, additional, Traykov, Latchezar, additional, Hort, Jakub, additional, Vyhnalek, Martin, additional, Rasmussen, Katrine Laura, additional, Qvist Thomassen, Jesper, additional, Pijnenburg, Yolande A.L., additional, Holstege, Henne, additional, van Swieten, John, additional, Ramakers, Inez, additional, Verhey, Frans, additional, van der Lugt, Aad, additional, Scheltens, Philip, additional, Ortega-Rojas, Jenny, additional, Concha Mera, Ana Gabriela, additional, Mahecha, Maria F., additional, Pardo, Rodrogo, additional, Arboleda, Gonzalo, additional, Graff, Caroline, additional, Papenberg, Goran, additional, Giedraitis, Vilmantas, additional, Boland, Anne, additional, Deleuze, Jean-François, additional, Armando de Marco, Luiz, additional, Nunes de Moraes, Edgar, additional, de Viana, Bernardo, additional, Túlio Gualberto Cintra, Marco, additional, Grsiwold, Anthony, additional, Forund, Tatiana, additional, Cruchaga, Carlos, additional, Haines, Jonathan, additional, Farrer, Lindsay, additional, DeStefano, Anita, additional, Wijsman, Ellen, additional, Mayeux, Richard, additional, Pericak-Vance, Margaret, additional, Kunkle, Brian, additional, Goate, Alison, additional, Schellenberg, Gerard D., additional, Vardarajan, Badri, additional, Wang, Li-San, additional, Leung, Yuk Yee, additional, Dalgard, Clifton, additional, Nicolas, Gael, additional, Wallon, David, additional, Dufouil, Carole, additional, Pasquier, Florence, additional, Hanon, Olivier, additional, Debette, Stéphanie, additional, Grünblatt, Edna, additional, Popp, Julius, additional, Angel, Bárbara, additional, Golger, Sergio, additional, Victoria Chacon, Maria, additional, Aranguiz, Rafael, additional, Orellana, Paulina, additional, Slachevsky, Andrea, additional, Gonzalez-Billault, Christian, additional, Albala, Cecilia, additional, Fuentes, Patricio, additional, Porter, Tenielle, additional, Laws, Simon M, additional, Sachdev, Perminder, additional, Mather, Karen, additional, Hauger, Richard L., additional, Merritt, Victoria, additional, Panizzon, Matthew, additional, Zhang, Rui, additional, Gaziano, Michael, additional, Ghidoni, Roberta, additional, Galimberti, Daniela, additional, Arosio, Beatrice, additional, Mecocci, Patrizia, additional, Solfrizzi, Vincenzo, additional, Parnetti, Lucilla, additional, Squassina, Alessio, additional, Tremolizzo, Lucio, additional, Borroni, Barbara, additional, Nacmias, Benedetta, additional, Caffarra, Paolo, additional, Seripa, Davide, additional, Rainero, Innocenzo, additional, Daniele, Antonio, additional, Piras, Fabrizio, additional, Miyashita, Akinori, additional, Hara, Norikazu, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Williams, Julie, additional, Masullo, Carlo, additional, Amouyel, Philippe, additional, Preux, Pierre-Marie, additional, Mbelesso, Pascal, additional, Bandzouzi, Bébène, additional, Saykin, Andy, additional, Jessen, Frank, additional, Kehoe, Patrick, additional, Van Duijn, Cornelia, additional, Gim, Jungsoo, additional, Ben Salem, Nesrine, additional, Frikke-Schmidt, Ruth, additional, Cherni, Lofti, additional, Greicius, Michael D., additional, Tsolaki, Magda, additional, Sánchez-Juan, Pascual, additional, Romano Silva, Marco Aurélio, additional, Sleegers, Kristel, additional, Ingelsson, Martin, additional, Dartigues, Jean-François, additional, Seshadri, Sudha, additional, Rossi, Giacomina, additional, Morelli, Laura, additional, Hiltunen, Mikko, additional, Sims, Rebecca, additional, van der Flier, Wiesje, additional, Andreassen, Ole, additional, Arboleda, Humberto, additional, Escott-Price, Valentina, additional, Ruiz, Agustín, additional, Lee, Kun Ho, additional, Ikeuchi, Takeshi, additional, Ramirez, Alfredo, additional, Logue, Mark, additional, and Lambert, Jean-Charles, additional

Published
2023
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45. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial

Author

Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Andrieu, Sandrine, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Cerda, Sandrine, Noëlle-Cuffi, Marie, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Li, Michael, Tong, Yung, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristel, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Paule, Marie, Martel, Bonceour, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, Olivier-Abbal, Pascale, Coley, Nicola, Cufi, Marie-Noëlle, Legrand, Philippe, Caubere, Jean-Paul, and Weiner, Michael

Published
2017
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48. Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

Author

Wolters, Frank J., Chibnik, Lori B., Waziry, Reem, Anderson, Roy, Berr, Claudine, Beiser, Alexa, Bis, Joshua C., Blacker, Deborah, Bos, Daniel, Brayne, Carol, Dartigues, Jean-François, Darweesh, Sirwan K.L., Davis-Plourde, Kendra L., de Wolf, Frank, Debette, Stephanie, Dufouil, Carole, Fornage, Myriam, Goudsmit, Jaap, Grasset, Leslie, Gudnason, Vilmundur, Hadjichrysanthou, Christoforos, Helmer, Catherine, Ikram, M. Arfan, Ikram, M. Kamran, Joas, Erik, Kern, Silke, Kuller, Lewis H., Launer, Lenore, Lopez, Oscar L., Matthews, Fiona E., McRae-McKee, Kevin, Meirelles, Osorio, Mosley, Thomas H., Jr, Pase, Matthew P., Psaty, Bruce M., Satizabal, Claudia L., Seshadri, Sudha, Skoog, Ingmar, Stephan, Blossom C.M., Wetterberg, Hanna, Wong, Mei Mei, Zettergren, Anna, and Hofman, Albert

Published
2020
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50. Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics

Author

Sargurupremraj, Muralidharan, primary, Soumare, Aicha, additional, Bis, Joshua C., additional, Surakka, Ida, additional, Jurgenson, Tuuli, additional, Joly, Pierre, additional, Knol, Maria J., additional, Wang, Ruiqi, additional, Yang, Qiong, additional, Satizabal, Claudia L., additional, Gudjonsson, Alexander, additional, Mishra, Aniket, additional, Bouteloup, Vincent, additional, Phuah, Chia-Ling, additional, van Duijn, Cornelia M., additional, Cruchaga, Carlos, additional, Dufouil, Carole, additional, Chene, Genevieve, additional, Lopez, Oscar, additional, Psaty, Bruce M., additional, Tzourio, Christophe, additional, Amouyel, Philippe, additional, Adams, Hieab H., additional, Jacqmin-Gadda, Helene, additional, Ikram, Mohammad Arfan, additional, Gudnason, Vilmundur, additional, Milani, Lili, additional, Winsvold, Bendik S., additional, Hveem, Kristian, additional, Matthews, Paul M., additional, Longstreth, WT, additional, Seshadri, Sudha, additional, Launer, Lenore J., additional, and Debette, Stephanie, additional

Published
2023
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