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10. Associations of screen use with cognitive development in early childhood: the ELFE birth cohort.

Author

Yang, Shuai, Saïd, Mélèa, Peyre, Hugo, Ramus, Franck, Taine, Marion, Law, Evelyn C., Dufourg, Marie‐Noëlle, Heude, Barbara, Charles, Marie‐Aline, and Bernard, Jonathan Y.

Subjects
COGNITIVE testing, BEHAVIOR modification, QUESTIONNAIRES, SCREEN time, AGE distribution, DESCRIPTIVE statistics, CHILD development, HEALTH behavior, VOCABULARY, SOCIODEMOGRAPHIC factors, CONFIDENCE intervals, REGRESSION analysis, CHILDREN
Abstract

Background: The associations of screen use with children's cognition are not well evidenced and recent, large, longitudinal studies are needed. We aimed to assess the associations between screen use and cognitive development in the French nationwide birth cohort. Methods: Time and context of screen use were reported by parents at ages 2, 3.5 and 5.5. Vocabulary, non‐verbal reasoning and general cognitive development were assessed with the MacArthur‐Bates Communicative Development Inventory (MB) at age 2, the Picture Similarities subtest from the British Ability Scales (PS) at age 3.5 and the Child Development Inventory (CDI) at ages 3.5 and 5.5. Outcome variables were age‐adjusted and standardized (mean = 100, SD = 15). Multiple imputations were performed among children (N = 13,763) with ≥1 screen use information and ≥1 cognitive measures. Cross‐sectional and longitudinal associations between screen use and cognitive development were assessed by linear regression models adjusted for sociodemographic and birth factors related to the family and children, and children's lifestyle factors competing with screen use. Baseline cognitive scores were further considered in longitudinal analysis. Results: TV‐on during family meals at age 2, not screen time, was associated with lower MB scores at age 2 (β [95% CI] = −1.67 [−2.21, −1.13]) and CDI scores at age 3.5 (−0.82 [−1.31, −0.33]). In cross‐sectional analysis, screen time was negatively associated with CDI scores at ages 3.5 (−0.67 [−0.94, −0.40]) and 5.5 (−0.47 [−0.77, −0.16]), and, in contrast, was positively associated with PS scores (0.39 [0.07, 0.71]) at age 3.5. Screen time at age 3.5 years was not associated with CDI scores at age 5.5 years. Conclusions: Our study found weak associations of screen use with cognition after controlling for sociodemographic and children's birth factors and lifestyle confounders, and suggests that the context of screen use matters, not solely screen time, in children's cognitive development. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Parents’ depression and anxiety associated with hyperactivity-inattention and emotional symptoms in children during school closure due to COVID-19 in France

Author

Monnier, Maëva, Moulin, Flore, Bailhache, Marion, Thierry, Xavier, Vandentorren, Stéphanie, Côté, Sylvana, Falissard, Bruno, Siméon, Thierry, Geay, Bertrand, Marchand-Martin, Laetitia, Dufourg, Marie-Noëlle, Charles, Marie-Aline, Ancel, Pierre-Yves, Melchior, Maria, Rouquette, Alexandra, Galéra, Cédric, SAPRIS study group, and The ELFE Joint Unit

Subjects
PARENTS, EPIDEMICS, FRANCE, CHILDREN, MENTAL_HEALTH, PSYCHOLOGICAL_FACTORS, DEPRESSION
Abstract

Several risk factors of children’s mental health issues have been identified during the pandemic of COronaVIrus Disease first appeared in 2019 (COVID-19). This study aims to fill the knowledge gap regarding the association between parents’ and children’s mental health issues during the COVID-19 school closure in France. We conducted a cross-sectional analysis of data collected in the SAPRIS-ELFE study during the COVID-19 pandemic in France. Using multinomial logistic regressions, we estimated associations between parents’ and children’s mental health issues. Symptoms of anxiety were assessed by the General Anxiety Disorder-7 (GAD-7) and depression by the Patient Health Questionnaire-9 (PHQ-9) for the parents. Hyperactivity/inattention and emotional symptoms in children were assessed by the Strengths and Difficulties Questionnaire (SDQ). The sample included 3496 children aged 8 to 9 years, of whom 50.0% were girls. During the school closure, 7.1% of responding parents had moderate to severe levels of anxiety and 6.7% had moderate to severe levels of depression. A total of 11.8% of the children had an abnormal hyperactivity/inattention score and 6.6% had an abnormal emotional symptoms score. In multivariate regression models, parental moderate to severe level of anxiety and moderate to severe level of depression were associated with abnormal hyperactivity-inattention score (adjusted Odds Ratio (aOR) 3.31; 95% Confidence Interval (CI) 2.33–4.70 and aOR 4.65; 95% CI 3.27–6.59, respectively) and abnormal emotional symptoms score in children (aOR 3.58; 95% CI 2.33–5.49 and aOR 3.78; 95 CI 2.47–5.78 respectively). Children whose parents have symptoms of anxiety and/or depression have an increased likelihood of symptoms of hyperactivity/inattention and emotional symptoms during school closures in France due to COVID-19. Our findings suggest that public health initiatives should target parents and children to limit the impact of such crises on their mental health issues.

Published
2023

17. Determinants of incomplete vaccination in children at age two in France: results from the nationwide ELFE birth cohort

Author

Jacques, Marianne, primary, Lorton, Fleur, additional, Dufourg, Marie-Noëlle, additional, Bois, Corinne, additional, Launay, Elise, additional, Siméon, Thierry, additional, Raude, Jocelyn, additional, Guen, Christèle Gras-Le, additional, Lévy-Brühl, Daniel, additional, Charles, Marie-Aline, additional, Chalumeau, Martin, additional, and Scherdel, Pauline, additional

Published
2022
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19. Emotional and attention-deficit/hyperactivity disorder symptoms of preterm vs. full-term children during COVID-19 pandemic restrictions

Author

Bailhache, Marion, Monnier, Maëva, Moulin, Flore, Thierry, Xavier, Vandentorren, Stéphanie, Côté, Sylvana M., Falissard, Bruno, Siméon, Thierry, Geay, Bertrand, Marchand, Laetitia, Dufourg, Marie-Noëlle, Charles, Marie-Aline, Ancel, Pierre-Yves, Melchior, Maria, Rouquette, Alexandra, Galéra, Cédric, and SAPRIS study group

Subjects
Pediatrics, Perinatology and Child Health, EPIDEMICS, FRANCE, CHILDREN, MENTAL_HEALTH, PSYCHOLOGICAL_FACTORS
Abstract

Background Preterm children are at higher risk of developing mental health problems than full-term children. Deterioration of children’s mental health was observed during COVID-19 pandemic restrictive measures. Our study compared emotional and attention-deficit/hyperactivity disorder (ADHD) symptoms during school closure between preterm and full-term children. Methods Data from two French birth cohorts—ELFE and EPIPAGE-2—were used. In 2011, infants born ≥22 weeks’ gestation were recruited. Parents completed the Strengths and Difficulties Questionnaire when the children were 9 years old and experiencing school closure. Multivariate multinomial logistic regression models were used. Results Subjects included 4164 full-term and 1119 preterm children. In univariate analyses, compared to full-term children: extremely and very preterm children more frequently had abnormal and borderline ADHD scores (odds ratio [OR] 1.86, 95% confidence interval [CI] 1.50–2.30, OR 1.42, 95% CI 1.08–1.85, respectively) and abnormal emotional scores (OR 1.86, 95% CI 1.43–2.40); moderate to late preterm children more often had abnormal ADHD scores (OR 1.33, 95% CI 1.01–1.78). The associations did not remain when previous symptoms at 5 years old were considered. Conclusions School closure during lockdown did not appear to increase the risk of mental health problems in preterm compared to full-term children.

Published
2022

20. Enrichment of Formula in Probiotics or Prebiotics and Risk of Infection and Allergic Diseases up to Age 5.5 Years in the Nationwide Etude Longitudinale Française depuis l'Enfance (ELFE) Cohort

Author

Adjibade, Moufidath, primary, Davisse-Paturet, Camille, additional, Divaret-Chauveau, Amandine, additional, Adel-Patient, Karine, additional, Raherison, Chantal, additional, Dufourg, Marie-Noëlle, additional, Lioret, Sandrine, additional, Charles, Marie-Aline, additional, and de Lauzon-Guillain, Blandine, additional

Published
2022
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28. Early postnatal growth and subsequent neurodevelopment in children delivered at term: The ELFE cohort study.

Author

Taine, Marion, Forhan, Anne, Morgan, Andrei S., Bernard, Jonathan Y., Peyre, Hugo, Dufourg, Marie‐Noëlle, Martin, Laetitia Marchand, Charles, Marie‐Aline, Botton, Jérémie, Heude, Barbara, Dufourg, Marie-Noëlle, and Charles, Marie-Aline

Abstract

Background: Despite the limited evidence, accelerated early postnatal growth (EPG) is commonly believed to benefit neurodevelopment for term-born infants, especially those small for gestational age.Objectives: To investigate the existence of critical time windows in the association of EPG with neurodevelopment, considering birth size groups.Study Design: In the French ELFE birth cohort, 12,854 term-born neonates were classified as small, appropriate or large for gestational age (SGA, AGA, LGA, respectively). Parents reported their child's development by using the Child Development Inventory (CDI-score) at age 12 months and the MacArthur-Bates Development Inventory (MAB-score; 100 score units) assessing language ability at age 24 months. Predictions of individual weight, body mass index (BMI), length, and head circumference (HC) from birth to age 24 months were obtained from repeated measurements fitted with the Jenss-Bayley mixed-effects model. For each infant, conditional gains (CG) in these growth parameters were generated at four-time points (3, 6, 12 and 24 months) representing specific variations in growth parameters during 0-3, 3-6, 6-12, 12-24 months, independent of previous measures. Using multivariable linear regression models, we provided the estimate differences of the neurodevelopmental scores according to variation of each growth parameter CG, by birth size group.Results: For SGA infants, the MAB-score differed by 5.8 (95% confidence interval [CI] -0.2, 11.8), 6.7 (95% CI -0.1, 13.3), and 9.7 (95% CI 1.9, 17.5) score units when CG in BMI, weight, and HC at 3 months varied from -2 to 1 standard deviation, respectively. For all infants, MAB-score was linearly and positively associated with length conditional gains at 12 months, with stronger magnitude for SGA infants. Results for the CDI-score were overall consistent with those for MAB-score.Conclusions: For term-born SGA infants, moderate catch-up in HC, BMI and weight within the first 3 months of life may benefit later neurodevelopment, which could guide clinicians to monitor EPG. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Whispers of change in childhood asthma: findings in the French ELFE cohort

Author

Khan, Sadia, primary, Ouaalaya, El Hassane, additional, Leynaert, Bénédicte, additional, De Blic, Jacques, additional, Marguet, Christophe, additional, Deschildre, Antoine, additional, Dufourg, Marie-Noëlle, additional, Bois, Corinne, additional, Charles, Marie-Aline, additional, Delmas, Marie Christine, additional, Divaret Chauveau, Amandine, additional, Scherer, Emeline, additional, Rocchi, Steffi, additional, Reboux, Gabriel, additional, Millon, Laurence, additional, and Raherison Semjen, Chantal, additional

Published
2021
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30. Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study

Author

Pierrat, Véronique, Marchand-Martin, Laetitia, Marret, Stéphane, Arnaud, Catherine, Benhammou, Valérie, Cambonie, Gilles, Debillon, Thierry, Dufourg, Marie-Noëlle, Gire, Catherine, Goffinet, François, Kaminski, Monique, Lapillonne, Alexandre, Morgan, Andrei Scott, Rozé, Jean-Christophe, Twilhaar, Sabrina, Charles, Marie-Aline, Ancel, Pierre-Yves, Langer, Bruno, Matis, Jacqueline, Kuhn, Pierre, Rebola, Muriel, Renesme, Laurent, Joly, Laurent, Lecomte, Benedicte, Datin-Dorriere, Valerie, Guillois, Bernard, Burguet, Antoine, Semama, Denis, Roué, Jean-Michel, Bretaudeau, Gilles, Rouget, Florence, Saliba, Elie, Favaris, Géraldine, Bednarek, Nathalie, Loron, Gauthier, Thiriez, Gerard, Chadie, Alexandra, de la Villéon, Gaëlle, Durrmeyer, Xavier, Granier, Michèle, Boileau, Pascal, Kayem, Gilles, Jarreau, Pierre-Henri, Foix-L’Hélias, Laurence, Boulot, Pierre, Daudé, Hubert, Bédu, Antoine, Mons, Fabienne, Deforge, Hélène, Fresson, Jeanne, Vayssière, Christophe, Breinig, Sophie, Truffert, Patrick, Nuytten, Alexandra, Charkaluk, Marie Laure, Brevaut, Veronique, Zahed, Meriem, Garcia, Patricia, Fayol, Laurence, Flamant, Cyril, Muller, Jean-Baptiste, Gascoin, Géraldine, Leke, André, Fontaine, Cécile, Claris, Olivier, Picaud, Jean-Charles, Ego, Anne, Patural, Hughes, Poulichet, Anne, Abrial, Aude, Favre, Anne, Fléchelles, Olivier, Ramful, Duksha, Carbonnier, Magali, Simeon, Thierry, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), CHU Rouen, Normandie Université (NU), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), Centre hospitalier universitaire de Nantes (CHU Nantes), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), French Institute of Public Health Research/Institute of Public HealthFrench Health MinistryPREMUP FoundationFondation de France11779Foundation for Medical ResearchSPF20160936356hospital clinical research programme EpinutriDGOS13-040Institut National de la Sante et de la Recherche Medicale (Inserm)National Institute of CancerNational Solidarity Fund for Autonomy (CNSA), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Paris Diderot, Equipe HAL, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Paris Cité (UPCité), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)

Subjects
Male, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Research, [SDV]Life Sciences [q-bio], Age Factors, Infant, Newborn, Gestational Age, Infant, Premature, Diseases, Cohort Studies, [SDV] Life Sciences [q-bio], Child Development, Neurodevelopmental Disorders, Case-Control Studies, Child, Preschool, Humans, Female, France, Infant, Premature, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Abstract Objectives To describe neurodevelopment at age 5 among children born preterm. Design Population based cohort study, EPIPAGE-2. Setting France, 2011. Participants 4441 children aged 5½ born at 24-26, 27-31, and 32-34 weeks Main outcome measures Severe/moderate neurodevelopmental disabilities, defined as severe/moderate cerebral palsy (Gross Motor Function Classification System (GMFCS) ≥2), or unilateral or bilateral blindness or deafness, or full scale intelligence quotient less than minus two standard deviations (Wechsler Preschool and Primary Scale of Intelligence, 4th edition). Mild neurodevelopmental disabilities, defined as mild cerebral palsy (GMFCS-1), or visual disability ≥3.2/10 and

Published
2021

31. Infant feeding practices and sleep at 1 year of age in the nationwide ELFE cohort

Author

Messayke, Sabine, Davisse-Paturet, Camille, Nicklaus, Sophie, Dufourg, Marie-Noëlle, Charles, Marie-Aline, de Lauzon-Guillain, Blandine, Plancoulaine, Sabine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Projet ELFE, ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Julien, Sabine, and Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID

Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, infant feeding, Infant, birth cohort, Original Articles, Infant Formula, Cohort Studies, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Breast Feeding, Humans, Female, Original Article, epidemiology, France, sleep, Infant Nutritional Physiological Phenomena, ELFE, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; Sleep problems reported by parents affect 20% to 30% of infants. Few studies focused on the longitudinal association between infant feeding practices and sleep, especially in France. Analyses were based on 8,696 infants from the French national birth cohort ELFE. Collection of feeding practices from birth to 10 months allowed for the identification of trajectories of use of baby cereals and thickened formula by group‐based trajectory modelling and calculation of duration of any breastfeeding (BF) and age at complementary feeding introduction (CFI) excluding baby cereals. Total sleep duration (TSD), night waking (NW) and sleep onset difficulties (SOD) were reported at age 1. Associations between feeding and sleep were tested by multinomial logistic regressions. BF duration ≥6 months was associated with parent‐reported frequent NW, SOD and TSD ≤ 12 h/24 h at age 1. For TSD and SOD, this association was no longer significant after accounting for parental sleep‐related practices. Early use of baby cereals (≤5 months) was associated with poor sleep. Early CFI (

Published
2021

32. Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study

Author

Pierrat, Véronique, primary, Marchand-Martin, Laetitia, additional, Marret, Stéphane, additional, Arnaud, Catherine, additional, Benhammou, Valérie, additional, Cambonie, Gilles, additional, Debillon, Thierry, additional, Dufourg, Marie-Noëlle, additional, Gire, Catherine, additional, Goffinet, François, additional, Kaminski, Monique, additional, Lapillonne, Alexandre, additional, Morgan, Andrei Scott, additional, Rozé, Jean-Christophe, additional, Twilhaar, Sabrina, additional, Charles, Marie-Aline, additional, and Ancel, Pierre-Yves, additional

Published
2021
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33. À trois ans et demi, les enfants d’origine modeste utilisent moins les dispositifs péri et surtout extrascolaires

Author

Thierry, Xavier, Siméon, Thierry, Charles, Marie-Aline, Dufourg, Marie-Noëlle, Geay, Bertrand, Guével, Catherine, Lanoë, Jean-Louis, Milcent, Karen, Popa, Ruxandra, and Zaros, Cécile

Subjects
SCHOOLS, SOCIAL_INEQUALITY, SOCIO-ECONOMIC_STATUS, SOCIALIZATION, CHILD_REARING, SOCIAL_CLASSES
Abstract

Rares sont les enfants n’allant pas à l’école maternelle à 3 ans et demi, mais tous n’en font pas la même expérience, puisque le temps passé avec l’enseignant ne représente qu’une partie de la journée en dehors du domicile. Les activités « non scolaires » amplifient le temps passé en collectivité par les enfants, qu’il s’agisse de la cantine, du centre de loisirs ou encore des pratiques physiques ou d’éveil artistique le mercredi ou le week-end. Un grand nombre d’enfants fréquentent précocement au moins l’un de ces services : la moitié des enfants âgés de 3 ans et demi mange tous les jours à la cantine, un quart fréquente quotidiennement le centre de loisirs, un tiers pratique une activité périscolaire le mercredi après‑midi ou extrascolaire en club, en association ou ailleurs. Les enfants de milieu populaire ou ceux dont l’un des parents est sans emploi y vont moins. Dans les 20 % de familles les plus modestes, un quart des enfants ne va à l’école que le matin. Leur journée est moins nourrie par cette forme de socialisation. L’accès quotidien des enfants à la cantine et au centre de loisirs présente peu de disparités territoriales, à l’exception des grandes agglomérations. En revanche, les enfants vivant en dehors des unités urbaines ont 20 % à 40 % moins de chances de pratiquer une activité extrascolaire en semaine que ceux habitant dans une unité urbaine hors agglomération parisienne. L’apprentissage d’une activité spécifique dans un club ou une association est socialement assez inégalitaire, car plutôt lié à des attentes éducatives propres aux parents diplômés. La fréquentation du centre de loisirs le mercredi découle plutôt des conditions de vie matérielles liées au statut familial et professionnel. Outre ces contacts plus fréquents avec des intervenants éducatifs, les enfants des parents les plus diplômés et les plus aisés consultent davantage un pédiatre.

Published
2020

34. Sleep habits and sleep characteristics at age 1 year in the ELFE birth cohort study

Author

Messayke, Sabine, Franco, Patricia, Forhan, Anne, Dufourg, Marie-Noëlle, Charles, Marie-Aline, Plancoulaine, Sabine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), EFS-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Azm and Saade Association, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Plancoulaine, Sabine

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Night waking, Sleep duration, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Epidemiology, Infant, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Birth-cohort, Sleep onset difficulty
Abstract

International audience; Infant sleep plays a critical role in normal development. Sleep problems, including sleep onset difficulties (SODs) and night waking (NW), range from 20% to 30% in infants and young children and can be persistent over time up to adulthood. Young French children seem to have longer sleep durations and less sleep troubles than their counterparts worldwide. Here, we aimed at describing infant sleep characteristics (total sleep time (TST)/24 h, NW, and SODs) and associated sleep habits in infants at age one year from the French nationwide birth cohort Etude Longitudinale Française depuis l'Enfance (ELFE).METHODS:This study included 11,783 infants with information on both sleep characteristics and sleep habits (parental presence when falling asleep, eating to fall asleep, sucking a pacifier or finger to sleep and sleep arrangement and location). Associations were studied by multinomial logistic regression analyses adjusted for familial and infant characteristics.RESULTS:Mean TST was 13 h36 min including 2 h54 min of naps; 20% of the infants had TST ≤12 h/24 h. About 46% did not present SOD or NW, 16% had frequent SODs and 22% had NW > 1 night in 2. Parental presence, feeding to fall asleep and infant sleep arrangements were frequent in infants with short sleep duration (≤12 h/24 h), NW and SODs. Non-nutritive sucking was associated with risk of NW, SOD and TST >14 h/24 h. Parental room sharing was associated with NW.CONCLUSION:This work provides new information on infant sleep arrangements and non-nutritive sucking that should be accounted for when considering sleep behaviors. In addition, most identified sleep habits associated with poor sleep characteristics may be amenable to change.

Published
2019

37. External validation of Asthma prediction tool in the French ELFE cohort

Author

Khan, Sadia, primary, Leynaert, Bénédicte, additional, Rocchi, Steffi, additional, Deblic, Jacques, additional, Marguet, Christophe, additional, Deschildre, Antoine, additional, Scherer, Emeline, additional, Reboux, Gabriel, additional, Delmas, Marie Christine, additional, Dufourg, Marie-Noëlle, additional, Bois, Corinne, additional, Charles, Marie-Aline, additional, Divaret-Chauveau, Amandine, additional, Millon, Laurence, additional, and Raherison, Chantal, additional

Published
2020
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39. Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

Author

Rocchi, Steffi, primary, Reboux, Gabriel, additional, Scherer, Emeline, additional, Laboissière, Audrey, additional, Zaros, Cécile, additional, Rouzet, Adeline, additional, Valot, Benoit, additional, Khan, Sadia, additional, Dufourg, Marie-Noëlle, additional, Leynaert, Bénédicte, additional, Raherison, Chantal, additional, and Millon, Laurence, additional

Published
2020
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40. Reply to J. Heinrich

Author

Davisse‐Paturet, Camille, primary, Raherison, Chantal, additional, Adel‐Patient, Karine, additional, Divaret‐Chauveau, Amandine, additional, Dufourg, Marie‐Noëlle, additional, Lioret, Sandrine, additional, Charles, Marie‐Aline, additional, and de Lauzon‐Guillain, Blandine, additional

Published
2019
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41. Breastfeeding Status and Duration and Infections, Hospitalizations for Infections and Antibiotic Use in the First Two Years of Life in the ELFE Cohort

Author

Davisse-Paturet, Camille, Adel-Patient, Karine, Divaret-Chauveau, Amandine, Pierson, Juliette, Lioret, Sandrine, Cheminat, Marie, Dufourg, Marie-Noëlle, Charles, Marie-Aline, De Lauzon-Guillain, Blandine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie et Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Biologie et de Technologies du CEA Saclay, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), The ELFE survey is a joint project between the French Institute for Demographic Studies (INED) and the National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement français du sang, EFS), Santé publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction générale de la santé (DGS, part of the Ministry of Health and Social Affairs), the Direction générale de la prévention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des études, de l’évaluation et des statistiques (DREES, Ministry of Health and Social Affairs), the Département des études, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l’éducation populaire (INJEP). Via the RECONAI platform, it received a government grant managed by the National Research Agency under the 'Investissements d’avenir' program (ANR-11-EQPX-0038)., ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), de Lauzon-Guillain, Blandine, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Adult, Male, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, breastfeeding, Infant, lcsh:TX341-641, birth cohort, Article, Anti-Bacterial Agents, Cohort Studies, Hospitalization, antibiotic use, Breast Feeding, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Communicable Disease Control, Humans, Female, Infant Food, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, infections, hospitalizations, lcsh:Nutrition. Foods and food supply
Abstract

In low- and middle-income countries, the protective effect of breastfeeding against infections is well established, but in high-income countries, the effect could be weakened by higher hygienic conditions. We aimed to examine the association between breastfeeding and infections in the first 2 years of life, in a high-income country with relatively short breastfeeding duration. Among 10,349 young children from the nationwide Etude Longitudinale Française depuis l’Enfance (ELFE) birth cohort, breastfeeding and parent-reported hospitalizations, bronchiolitis and otitis events, and antibiotic use were prospectively collected up to 2 years. Never-breastfed infants were used as reference group. Any breastfeeding for

Published
2019

42. Social Inequalities in Prenatal Folic Acid Supplementation: Results from the ELFE Cohort

Author

Camier, Aurore, Kadawathagedara, Manik, Lioret, Sandrine, Bois, Corinne, Cheminat, Marie, Dufourg, Marie-Noëlle, Charles, Marie Aline, de Lauzon-Guillain, Blandine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), This analysis was funded by an ANR grant within the framework 'Social determinants of health' (grant number: ANR-12-DSSA-0001). The Elfe survey is a joint project between the French Institute for Demographic Studies (INED) and the National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement français du sang, EFS), Santé publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction générale de la santé (DGS, part of the Ministry of Health and Social Affairs), the Direction générale de la prévention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des études, de l’évaluation et des statistiques (DREES, Ministry of Health and Social Affairs), the Département des études, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l’éducation populaire (INJEP). Via the RECONAI platform, it receives a government grant managed by the National Research Agency under the 'Investissements d’avenir' programme (ANR-11-EQPX-0038)., ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), ANR-12-DSSA-0001,SOFI,Déterminants socio-culturel des pratiques alimentaires dans l'enfance(2012), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), de Lauzon-Guillain, Blandine, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, and Déterminants sociaux de santé - Déterminants socio-culturel des pratiques alimentaires dans l'enfance - - SOFI2012 - ANR-12-DSSA-0001 - DSS - VALID

Subjects
Adult, social inequalities, lcsh:TX341-641, Article, Young Adult, Folic Acid, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Dietary Supplements, Humans, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, France, Neural Tube Defects, pregnancy, Child, Prenatal Nutritional Physiological Phenomena, lcsh:Nutrition. Foods and food supply, folic acid supplementation
Abstract

Most professional and international organizations recommend folic acid supplementation for women planning pregnancy. Various studies have shown high levels of non-compliance with this recommendation. This study aimed to identify sociodemographic characteristics related to this compliance. The analyses were based on 16,809 women from the French nationwide ELFE cohort (Etude Longitudinale Fran&ccedil, aise depuis l&rsquo, Enfance). Folic acid supplementation was assessed at delivery, and sociodemographic characteristics were collected at two months postpartum. The association between sociodemographic characteristics and compliance with recommendations on folic acid supplementation (no supplementation, periconceptional supplementation, and supplementation only after the periconceptional period) was examined using multivariate multinomial logistic regression. Only 26% of French women received folic acid supplementation during the periconceptional period, 10% of women received supplementation after the periconceptional period, and 64% received no supplementation. Young maternal age, low education level, low family income, multiparity, single parenthood, maternal unemployment, maternal overweight, and smoking during pregnancy were related to lower likelihood of folic acid supplementation during the periconceptional period compared to no supplementation. These associations were not explained by unplanned pregnancy. Immigrant and underweight women were more likely to receive folic acid supplementation after the periconceptional period. Our study confirms great social disparities in France regarding the compliance with the recommendations on folic acid supplementation.

Published
2019
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43. Iron‐fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort

Author

Sacri, Anne-Sylvia, de Lauzon-Guillain, Blandine, Dufourg, Marie-Noëlle, Bois, Corinne, Charles, Marie Aline, Chalumeau, Martin, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Département de Pédiatrie et maladies infectieuses [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Service départemental de PMI [Nanterre], Conseil départemental des Hauts-de-Seine, Equipe 6 : ORCHAD - Origines précoces de la santé du développement de l'enfant (CRESS - U1153), Paris Diderot Université Sorbonne Paris Cité - Secteur Français des Aliments de l'Enfance, French Ministry of Health 'DGOS PHRC régional 2014' AOR14053- Ministry of Higher Education & Scientific Research (MHESR)- Institut national de la jeunesse et de l'éducation populaire (INJEP) - French National Research Agency (ANR), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Funding was received from Paris Diderot University - Sorbonne Paris Cité for a doctoral grant for Dr Sacri. Funding was received from institutions for another research project: Secteur Français des Aliments de l’Enfance (Dr Sacri and Pr Chalumeau), French Ministry of Health 'DGOS PHRC régional 2014 n° AOR14053' (Dr Sacri and Pr Chalumeau).

Subjects
Population-based cohort study, Primary prevention, Iron deficiency, Infant formula, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Socioeconomic factors
Abstract

Marie Aline Charles, PhD and Martin Chalumeau, MD, PhD : are equally contribution.; International audience; AIM:To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors.METHODS:The ELFE national birth cohort included, in 2011, 18 329 living births in 349 hospitals randomly selected. The present analyses were restricted to children with follow-up at age two years. Milk consumption was evaluated by parental telephone interview, and its association with socioeconomic factors was studied.RESULTS:The 12 341 analysed children had a mean age of 26 months; 50% were girls. Rate of IFF use before two years old and at two years old was 65% and 43%, respectively. At age two years, use of IFF was lower with young age of the mother (adjusted OR [aOR] = 0.4, 95% CI: 0.3-0.5), low educational level (aOR = 0.7, 95% CI: 0.6-0.9), high parity (aOR = 0.3, 95% CI 0.2-0.4), and mother smoking (aOR = 0.8, 95% CI: 0.7-0.9) as well as low household income (aOR = 0.5, 95% CI: 0.4-0.7), and parents' unemployment (aOR = 0.7, 95% CI: 0.5-0.9).CONCLUSION:In this national population-based study, the rate of implementation of the ID prevention strategy was much lower at two years old than before two years old, and significantly lower in disadvantaged populations.

Published
2019

44. 11p15 Imprinting Center Region 1 Loss of Methylation Is a Common and Specific Cause of Typical Russell-Silver Syndrome: Clinical Scoring System and Epigenetic-Phenotypic Correlations

Author

Netchine, Irène, Rossignol, Sylvie, Dufourg, Marie-Noëlle, Azzi, Salah, Rousseau, Alexandra, Perin, Laurence, Houang, Muriel, Steunou, Virginie, Esteva, Blandine, Thibaud, Nathalie, Demay, Marie-Charles Raux, Danton, Fabienne, Petriczko, Elzbieta, Bertrand, Anne-Marie, Heinrichs, Claudine, Carel, Jean-Claude, Loeuille, Guy-André, Pinto, Graziella, Jacquemont, Marie-Line, Gicquel, Christine, Cabrol, Sylvie, and Le Bouc, Yves

Published
2007

45. Pregnancy outcomes in women with preexisting thyroid diseases: a French cohort study.

Author

Lecorguillé, Marion, Léger, Juliane, Forhan, Anne, Cheminat, Marie, Dufourg, Marie-Noëlle, Heude, Barbara, and Charles, Marie-Aline

Subjects
THYROID diseases, HYPOTHYROIDISM, PREGNANCY complications, THYROID hormones, PREGNANCY
Abstract

Women with thyroid diseases at the beginning of pregnancy may have suboptimal thyroid hormone levels because of potential difficulties in compensating for the physiological thyroid hormone changes occurring in pregnancy. Our objective was to study the association between preexisting thyroid diseases, pregnancy complications, and neonatal anthropometry. In total, 16,395 women from the ELFE French longitudinal birth cohort were included, and 273 declared pre-pregnancy thyroid diseases. Associations were investigated with multivariable regression models, with adjustment for relevant potential confounders. Body mass index (BMI) was additionally adjusted for in a second stage. As compared with other women, women with pre-pregnancy thyroid diseases were more frequently obese (19.6% vs. 9.8%) and had greater odds of gestational diabetes development (odds ratio [OR] = 1.58 [95% confidence interval [CI] 1.08, 2.30]) or had undergone treatment for infertility (OR = 1.57 [95% CI 1.07, 2.31]). After adjustment for BMI, the association with gestational diabetes was no longer significant (OR = 1.27 [95% CI 0.86, 1.88]). After excluding women with another medical history, those with pre-pregnancy thyroid diseases had increased odds of premature rupture of membranes (OR = 1.51 [95% CI 1.01, 2.25]). Children born from mothers with hypothyroidism before conception due to a disease or as a potential side effect of treatment had a smaller head circumference at birth than other children (β = −0.23 [95% CI −0.44, −0.01] cm). In conclusion, pre-pregnancy thyroid diseases were associated with risk of infertility treatment, gestational diabetes, and premature rupture of membranes. The association between history of hypothyroidism and moderate adverse effects on fetal head circumference growth needs replication. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Profils de multi-expositions professionnelles maternelles durant la grossesse et association avec la croissance intra-utérine : résultats de la cohorte ELFE

Author

Tartaglia, Marie, Costet, Nathalie, Audignon-Durand, Sabyne, Cardis, Elisabeth, Carles, Camille, Descatha, Alexis, Falkstedt, Daniel, Houot, Marie, Kjellberg, Katarina, Pilorget, Corinne, Roeleveld, Nel, Turner, Michelle, Turuban, Maxime, Uuksulainen, Sanni, Dufourg, Marie Noëlle, GarlantÉzec, Ronan, and Delva, Fleur

Abstract

Les expositions professionnelles, susceptibles d’accroître les risques pour la santé, sont souvent étudiées de manière indépendante les unes des autres, sans intégrer la problématique des expositions multiples, qui représente pourtant la réalité des situations professionnelles. L’absence de prise en compte de ces multi-expositions pourrait expliquer certains résultats contradictoires observés dans la littérature entre expositions professionnelles et développement intra utérin. À ce jour, aucune étude épidémiologique n’a réellement pris en compte l’impact des multi-expositions professionnelles maternelles sur la croissance intra-utérine. Les objectifs de notre étude sont d’identifier des profils de multi-expositions professionnelles maternelles durant la grossesse et d’étudier leur association avec la croissance intra-utérine au sein de la cohorte nationale mère-enfant ELFE. Les expositions professionnelles à 50 facteurs (chimiques, physiques, biologiques, biomécaniques, organisationnels, psychosociaux) ont été identifiées à partir de matrices emplois expositions. Les mères ont été classées comme exposées, probablement exposées, non exposées, en fonction de la probabilité d’exposition liée à leur activité professionnelle. Les événements étudiés sont le poids de naissance, le petit poids pour l’âge gestationnel (SGA) et le périmètre crânien. Les profils de multi-expositions ont été déterminés par classification hiérarchique basée sur les facteurs issus d’une analyse des correspondances multiples. Des modèles de régression linéaire et logistique ont ensuite permis d’étudier le lien entre ces profils et les issues de grossesse en ajustant sur les facteurs de confusion potentiels. Les 12 851 mères incluses dans l’étude étaient exposées à 8 facteurs, en moyenne, dont au moins un biomécanique. Cinq profils de multi-expositions ont été identifiés, caractérisés par : (1) travail peu exposé, stress au travail, (2) contraintes posturales, forte latitude décisionnelle, (3) contraintes posturales, travail intense, (4) contraintes posturales, risques chimiques et biologiques, (5) accumulation de tous les types de contraintes. Les études d’associations montrent une augmentation du risque de SGA dans le profil 5, par rapport au profil 1. Il n’y a pas d’associations significatives avec les autres profils, ni avec les autres indicateurs de croissance intra-utérine. Cette étude a permis d’identifier différents profils d’exposition à des facteurs de risque professionnels de femmes pendant la grossesse et leurs associations avec la croissance fœtale. Le cumul de contraintes liées à la profession d’aide-soignante semble particulièrement associé à une augmentation du risque de petit poids pour l’âge gestationnel.

Published
2024
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48. Supplementary data to: Pregnancy outcomes in women wiht pre-existing thyroid diseases: a french cohort study

Author

Lecorguillé, Marion, Léger, Juliane, Forhan, Anne, Cheminat, Marie, Dufourg, Marie-Noëlle, Heude, Barbara, Charles, Marie-Aline, Duchange, Nathalie, Equipe 6 : ORCHAD - Origines précoces de la santé du développement de l'enfant (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Université Sorbonne Paris Cité (USPC), Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), and Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Supplementary Tables 1 and 2. Article under submission in J Clin Endocrinol Metab.

Published
2018

49. Infant milk feeding at 2 months and incidence of eczema, food allergy or respiratory symptoms up to 2 years in the nationwide ELFE cohort study

Author

Davisse-Paturet, Camille, Raherison, Chantal, Adel-Patient, Karine, Divaret-Chauveau, Amandine, Bois, Corinne, Dufourg, Marie-Noëlle, Lioret, Sandrine, Charles, Marie-Aline, de Lauzon-Guillain, Blandine, and de Lauzon-Guillain, Blandine

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Background & aimour aim was to examine the associations between infant milk-feeding, focusing on protein hydrolysis in formula, and incidence of allergies or respiratory symptoms in toddlerhood.MethodAmong more than 8 000 infants from the ELFE study, we examined the association between milk feeding (breastmilk only, partially hydrolyzed infant formula with or without a hypoallergenic label (pHF-HA, pHF-non-HA) and intact-protein formula) at 2 months and incidence of eczema, food allergies or respiratory symptoms (wheezing, bronchiolitis episodes, asthma) as declared by the parents up to 2 years, using multivariate logistic regressions, with predominant breastmilk as reference. We also performed analyses stratified by familial allergy status.ResultsPredominant breastfeeding at 2 months was related to lower risk of eczema, wheezing and frequent bronchiolitis episodes at 1 year compared to formula feeding. The use of pHF-HA at 2 months was related to both higher risk of frequent bronchiolitis episodes, and wheezing at 1 year and higher risk of frequent bronchiolitis episodes and food allergy at 2 years compared infants fed formula with intact proteins. Similar results In the stratified analyses, the increase risk related to the use of pHF-HA at 2 months was found in both non-at-risk and at-risk infants. A higher risk for frequent bronchiolitis episodes at 1 and 2 years was seen in at-risk infants while a higher risk for food allergy at 2 years was mainly observed in non-at-risk infants. ConclusionsWe confirmed a protective effect of breastfeeding on eczema, wheezing and frequent bronchiolitis episodes at 1 year but did not find any protective effect of pHF.

Published
2018

50. Alimentation lactée à 2 mois et allergies - cohorte ELFE

Author

Davisse-Paturet, Camille, Raherison, Chantal, Adel-Patient, Karine, Chauveau, Amandine, Bois, Corinne, Dufourg, Marie-Noëlle, Lioret, Sandrine, Charles, Marie-Aline, de Lauzon-Guillain, Blandine, de Lauzon-Guillain, Blandine, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), Université de Lorraine (UL), Service d’allergologie pédiatrique [CHRU de Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and service départemental de PMI des Hauts - de - Seine

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Les préparations infantiles (PI) hypoallergéniques (HA) sont utilisées en prévention des allergies chez les enfants à risque.Dans la cohorte de naissance ELFE, l’alimentation lactée a été évaluée à 2 mois et l’eczéma, les sifflements et les bronchiolites à 2 mois, 1 an et 2 ans. Les allergies alimentaires ont été déclarées à 2 mois et 2 ans. Les associations entre l’alimentation lactée à 2 mois et l’incidence des allergies ont été étudiées chez plus de 8 000 enfants par régressions logistiques, avec pour catégorie de référence le lait maternel. Les enfants présentant des allergies alimentaires à 2 mois ou utilisant des PI pour enfant allergique ont été exclus des analyses.L’utilisation de PI à 2 mois était associée avec un risque accru de bronchiolites fréquentes à 1 an. L’utilisation de PI-HA à 2 mois était associée à un risque accru de bronchiolites fréquentes à 1 et 2 ans (OR=2,6 [1,6-4,5] ; OR=2,3 [1,4-3,9], respectivement), de sifflements à 1 an (OR=1,9 [1,4-2,5]) et d’allergies alimentaires à 2 ans (OR=2,1 [1,2-3,9]). L’eczéma déclaré à 1 ou 2 ans et l’asthme déclaré à 2 ans n’étaient pas associés à l’alimentation lactée à 2 mois.Les PI-HA ne semblent pas prévenir des allergies jusqu’à 2 ans, même après prise en compte du risque familial d’allergie.

Published
2018

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