22 results on '"Duggal, Ruchia"'
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2. Metabolism and excretion of therapeutic peptides: current industry practices and recommendations
3. Optimization of Peptide Drug Exposures for Pharmacological Efficacy: DMPK Considerations
4. Rapid label-free cell-based Approach Membrane Permeability Assay using MALDI-hydrogen-deuterium exchange mass spectrometry for peptides
5. Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor.
6. Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics
7. Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations
8. Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
9. Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1
10. Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology
11. Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1
12. Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
13. NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
14. Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
15. Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12CInhibitor
16. Cytochrome b 5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step
17. Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone
18. Mechanism and Modulation of Human Androgen Synthesis
19. Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis
20. Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy‐complex in the lyase step.
21. Kinetic solvent isotope effect in steady‐state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps
22. Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
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