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975 results on '"Dujardin, Jean-Claude"'

1. Source Tracing of Leishmania donovani in Emerging Foci of Visceral Leishmaniasis, Western Nepal

Author

Monsieurs, Pieter, Cloots, Kristien, Uranw, Surendra, Banjara, Megha Raj, Ghimire, Prakash, Burza, Sakib, Hasker, Epco, Dujardin, Jean-Claude, and Domagalska, Malgorzata Anna

Subjects
Leishmania -- Identification and classification -- Genetic aspects, Kala-azar -- Causes of, Health
Abstract

Leishmania spp. are parasitic protozoans that cause human leishmaniasis in multiple forms, including visceral leishmaniasis (VL), which affects the internal organs. For decades, the Indian subcontinent (ISC)-a geographic region that [...]

Published
2024
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3. A community resource for paired genomic and metabolomic data mining

Author

Schorn, Michelle A, Verhoeven, Stefan, Ridder, Lars, Huber, Florian, Acharya, Deepa D, Aksenov, Alexander A, Aleti, Gajender, Moghaddam, Jamshid Amiri, Aron, Allegra T, Aziz, Saefuddin, Bauermeister, Anelize, Bauman, Katherine D, Baunach, Martin, Beemelmanns, Christine, Beman, J Michael, Berlanga-Clavero, María Victoria, Blacutt, Alex A, Bode, Helge B, Boullie, Anne, Brejnrod, Asker, Bugni, Tim S, Calteau, Alexandra, Cao, Liu, Carrión, Víctor J, Castelo-Branco, Raquel, Chanana, Shaurya, Chase, Alexander B, Chevrette, Marc G, Costa-Lotufo, Leticia V, Crawford, Jason M, Currie, Cameron R, Cuypers, Bart, Dang, Tam, de Rond, Tristan, Demko, Alyssa M, Dittmann, Elke, Du, Chao, Drozd, Christopher, Dujardin, Jean-Claude, Dutton, Rachel J, Edlund, Anna, Fewer, David P, Garg, Neha, Gauglitz, Julia M, Gentry, Emily C, Gerwick, Lena, Glukhov, Evgenia, Gross, Harald, Gugger, Muriel, Guillén Matus, Dulce G, Helfrich, Eric JN, Hempel, Benjamin-Florian, Hur, Jae-Seoun, Iorio, Marianna, Jensen, Paul R, Kang, Kyo Bin, Kaysser, Leonard, Kelleher, Neil L, Kim, Chung Sub, Kim, Ki Hyun, Koester, Irina, König, Gabriele M, Leao, Tiago, Lee, Seoung Rak, Lee, Yi-Yuan, Li, Xuanji, Little, Jessica C, Maloney, Katherine N, Männle, Daniel, Martin H., Christian, McAvoy, Andrew C, Metcalf, Willam W, Mohimani, Hosein, Molina-Santiago, Carlos, Moore, Bradley S, Mullowney, Michael W, Muskat, Mitchell, Nothias, Louis-Félix, O’Neill, Ellis C, Parkinson, Elizabeth I, Petras, Daniel, Piel, Jörn, Pierce, Emily C, Pires, Karine, Reher, Raphael, Romero, Diego, Roper, M Caroline, Rust, Michael, Saad, Hamada, Saenz, Carmen, Sanchez, Laura M, Sørensen, Søren Johannes, Sosio, Margherita, Süssmuth, Roderich D, Sweeney, Douglas, Tahlan, Kapil, Thomson, Regan J, Tobias, Nicholas J, Trindade-Silva, Amaro E, and van Wezel, Gilles P

Subjects
Human Genome, Genetics, Biotechnology, Generic health relevance, Data Mining, Databases, Factual, Genomics, Metabolomics, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

Published
2021

4. Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics

Author

Van den Broeck, Frederik, Heeren, Senne, Maes, Ilse, Sanders, Mandy, Cotton, James A., Cupolillo, Elisa, Alvarez, Eugenia, Garcia, Lineth, Tasia, Maureen, Marneffe, Alice, Dujardin, Jean-Claude, and Van der Auwera, Gert

Subjects
Heat shock proteins -- Analysis, Meglumine antimoniate -- Identification and classification -- Control, Leishmaniasis -- Diagnosis -- Care and treatment, Health
Abstract

Leishmania are intracellular protozoan parasites that cause the vectorborne disease leishmaniasis, which occurs in [approximately equal to] 88 countries (1). Human infection can result in 2 main forms of disease, [...]

Published
2023

6. Ecological divergence and hybridization of Neotropical Leishmania parasites

Author

Van den Broeck, Frederik, Savill, Nicholas J., Imamura, Hideo, Sanders, Mandy, Maes, Ilse, Cooper, Sinclair, Mateus, David, Jara, Marlene, Adaui, Vanessa, Arevalo, Jorge, Llanos-Cuentas, Alejandro, Garcia, Lineth, Cupolillo, Elisa, Miles, Michael, Berriman, Matthew, Schnaufer, Achim, Cotton, James A., and Dujardin, Jean-Claude

Published
2020

8. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions

Author

De Muylder, Géraldine, Vanhollebeke, Benoit, Caljon, Guy, Wolfe, Alan R, McKerrow, James, and Dujardin, Jean-Claude

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Orphan Drug, Infectious Diseases, Vector-Borne Diseases, Rare Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Host-Parasite Interactions, Humans, Leishmania donovani, Leishmaniasis, Macrolides, Macrophages, Naloxone, RNA, Small Interfering, Tissue Array Analysis, Vacuolar Proton-Translocating ATPases, Vacuoles, Biological Sciences, Medical and Health Sciences, Tropical Medicine, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Host-directed therapies (HDTs) constitute promising alternatives to traditional therapy that directly targets the pathogen but is often hampered by pathogen resistance. HDT could represent a new treatment strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania. This protozoan develops exclusively within phagocytic cells, where infection relies on a complex molecular interplay potentially exploitable for drug targets. We previously identified naloxonazine, a compound specifically active against intracellular but not axenic Leishmania donovani. We evaluated here whether this compound could present a host cell-dependent mechanism of action. Microarray profiling of THP-1 macrophages treated with naloxonazine showed upregulation of vATPases, which was further linked to an increased volume of intracellular acidic vacuoles. Treatment of Leishmania-infected macrophages with the vATPase inhibitor concanamycin A abolished naloxonazine effects, functionally demonstrating that naloxonazine affects Leishmania amastigotes indirectly, through host cell vacuolar remodeling. These results validate amastigote-specific screening approaches as a powerful way to identify alternative host-encoded targets. Although the therapeutic value of naloxonazine itself is unproven, our results further demonstrate the importance of intracellular acidic compartments for host defense against Leishmania, highlighting the possibility of targeting this host cell compartment for anti-leishmanial therapy.

Published
2016

9. Onchocerca volvulus transmission in the Mbam valley of Cameroon following 16 years of annual community-directed treatment with ivermectin, and the description of a new cytotype of Simulium squamosum

Author

Hendy, Adam, Krit, Meryam, Pfarr, Kenneth, Laemmer, Christine, De Witte, Jacobus, Nwane, Philippe, Kamgno, Joseph, Nana-Djeunga, Hugues C., Boussinesq, Michel, Dujardin, Jean-Claude, Post, Rory, Colebunders, Robert, O’Neill, Sarah, Enyong, Peter, and Njamnshi, Alfred K.

Published
2021
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17. Extreme inbreeding in Leishmania braziliensis

Author

Rougeron, Virginie, De Meeûs, Thierry, Hide, Mallorie, Waleckx, Etienne, Bermudez, Herman, Arevalo, Jorge, Llanos-Cuentas, Alejandro, Dujardin, Jean-Claude, De Doncker, Simone, Le Ray, Dominique, Ayala, Francisco J, and Bañuls, Anne-Laure

Subjects
Vector-Borne Diseases, Infectious Diseases, Human Genome, Genetics, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Animals, Bolivia, Heterozygote, Humans, Leishmania braziliensis, Linkage Disequilibrium, Microsatellite Repeats, Peru, Polymorphism, Genetic, Reproduction, clonality, microsatellites, population genetics, endogamyl, heterozygote defiency
Abstract

Leishmania species of the subgenus Viannia and especially Leishmania braziliensis are responsible for a large proportion of New World leishmaniasis cases. The reproductive mode of Leishmania species has often been assumed to be predominantly clonal, but remains unsettled. We have investigated the genetic polymorphism at 12 microsatellite loci on 124 human strains of Leishmania braziliensis from 2 countries, Peru and Bolivia. There is substantial genetic diversity, with an average of 12.4 +/- 4.4 alleles per locus. There is linkage disequilibrium at a genome-wide scale, as well as a substantial heterozygote deficit (more than 50% the expected value from Hardy-Weinberg equilibrium), which indicates high levels of inbreeding. These observations are inconsistent with a strictly clonal model of reproduction, which implies excess heterozygosity. Moreover, there is large genetic heterogeneity between populations within countries (Wahlund effect), which evinces a strong population structure at a microgeographic scale. Our findings are compatible with the existence of population foci at a microgeographic scale, where clonality alternates with sexuality of an endogamic nature, with possible occasional recombination events between individuals of different genotypes. These findings provide key clues on the ecology and transmission patterns of Leishmania parasites.

Published
2009

23. Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy

Author

Lukeš, Julius, Mauricio, Isabel L, Schönian, Gabriele, Dujardin, Jean-Claude, Soteriadou, Ketty, Dedet, Jean-Pierre, Kuhls, Katrin, Tintaya, K Wilber Quispe, Jirků, Milan, Chocholová, Eva, Haralambous, Christos, Pratlong, Francine, Oborník, Miroslav, Horák, Aleš, Ayala, Francisco J, and Miles, Michael A

Subjects
Infectious Diseases, Biotechnology, Genetics, Vector-Borne Diseases, Good Health and Well Being, Animals, Biological Evolution, Genetic Markers, Genetic Speciation, Geography, Leishmania donovani, Time Factors, Leishmania infantum, leishmaniasis, parasitic protozoa, phylogeny, population genetics
Abstract

Leishmaniasis is a geographically widespread severe disease, with an increasing incidence of two million cases per year and 350 million people from 88 countries at risk. The causative agents are species of Leishmania, a protozoan flagellate. Visceral leishmaniasis, the most severe form of the disease, lethal if untreated, is caused by species of the Leishmania donovani complex. These species are morphologically indistinguishable but have been identified by molecular methods, predominantly multilocus enzyme electrophoresis. We have conducted a multifactorial genetic analysis that includes DNA sequences of protein-coding genes as well as noncoding segments, microsatellites, restriction-fragment length polymorphisms, and randomly amplified polymorphic DNAs, for a total of approximately 18,000 characters for each of 25 geographically representative strains. Genotype is strongly correlated with geographical (continental) origin, but not with current taxonomy or clinical outcome. We propose a new taxonomy, in which Leishmania infantum and L. donovani are the only recognized species of the L. donovani complex, and we present an evolutionary hypothesis for the origin and dispersal of the species. The genus Leishmania may have originated in South America, but diversified after migration into Asia. L. donovani and L. infantum diverged approximately 1 Mya, with further divergence of infraspecific genetic groups between 0.4 and 0.8 Mya. The prevailing mode of reproduction is clonal, but there is evidence of genetic exchange between strains, particularly in Africa.

Published
2007

27. Genome diversity of Leishmania aethiopica

Author

Hadermann, Amber, primary, Heeren, Senne, additional, Maes, Ilse, additional, Dujardin, Jean-Claude, additional, Domagalska, Malgorzata Anna, additional, and Van den Broeck, Frederik, additional

Published
2023
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28. Parasite hybridization promotes spreading of endosymbiotic viruses

Author

Heeren, Senne, primary, Maes, Ilse, additional, Sanders, Mandy, additional, Lye, Lon-Fye, additional, Arevalo, Jorge, additional, Llanos-Cuentas, Alejandro, additional, Garcia, Lineth, additional, Lemey, Philippe, additional, Beverley, Stephen M, additional, Cotton, James A, additional, Dujardin, Jean-Claude, additional, and Van den Broeck, Frederik, additional

Published
2023
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32. Genome diversity ofLeishmania aethiopica

Author

Hadermann, Amber, primary, Heeren, Senne, additional, Maes, Ilse, additional, Dujardin, Jean-Claude, additional, Domagalska, Malgorzata Anna, additional, and Van den Broeck, Frederik, additional

Published
2023
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37. Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Author

Cuypers, Bart, primary, Meysman, Pieter, additional, Erb, Ionas, additional, Bittremieux, Wout, additional, Valkenborg, Dirk, additional, Baggerman, Geert, additional, Mertens, Inge, additional, Sundar, Shyam, additional, Khanal, Basudha, additional, Notredame, Cedric, additional, Dujardin, Jean-Claude, additional, Domagalska, Malgorzata A., additional, and Laukens, Kris, additional

Published
2022
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40. Drug Resistance Assays for Parasites

Author

Sangster, N. C., Maitland, G. N., Geerts, S., Decuypere, Saskia, Dujardin, Jean-Claude, Upcroft, J. A., Upcroft, P., Duraisingh, M., Georgiev, Vassil St., editor, and Mayers, Douglas L., editor

Published
2009
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42. Reply to Das

Author

Dujardin, Jean-Claude, Bhattarai, Narayan R., Rai, Keshav, Vanaerschot, Manu, Uranw, Surendra, Ostyn, Bart A., Boelaert, Marleen, and Rijal, Suman

Published
2013
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