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1. The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia

Author

Duman D, Aksoy E, Agca MC, Kocak ND, Ozmen I, Akturk UA, Gungor S, Tepetam FM, Eroglu SA, Oztas S, and Karakurt Z

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Dildar Duman, Emine Aksoy, Meltem Coban Agca, Nagihan Durmus Kocak, Ipek Ozmen, Ulku Aka Akturk, Sinem Gungor, Fatma Merve Tepetam, Selma Aydogan Eroglu, Selahattin Oztas, Zuhal Karakurt Sureyyapasa Chest Diseases and Thoracic Surgery Teaching Hospital, Istanbul, Turkey Background: COPD exacerbations requiring hospitalization increase morbidity and mortality. Although most COPD exacerbations are neutrophilic, approximately 10%–25% of exacerbations are eosinophilic.Aim: We aimed to evaluate mortality and outcomes of eosinophilic and non-eosinophilic COPD exacerbations and identify new biomarkers that predict survival.Methods: A retrospective observational cohort study was carried out in a tertiary teaching hospital from January 1, 2014 to November 1, 2014. All COPD patients hospitalized with exacerbations were enrolled in the study at their initial hospitalization and followed-up for 6 months after discharge. Electronic data were collected from the hospital database. Subjects’ characteristics, hemogram parameters, CRP levels, neutrophil-to-lymphocyte ratio (NLR), platelet-to-mean platelet volume ratio on admission and discharge, length of hospital stay (days), readmissions, and mortality were recorded. Patients were grouped according to peripheral blood eosinophil (PBE) levels: Group 1, >2% PBE, eosinophilic; Group 2, non-eosinophilic ≤2%. Patient survival after hospital discharge was evaluated by Kaplan–Meier survival analysis.Results: A total of 1,704 patients hospitalized with COPD exacerbation were included. Approximately 20% were classified as eosinophilic. Six-month mortality was similar in eosinophilic and non-eosinophilic groups (14.2% and 15.2%, respectively); however, the hospital stay length and readmission rate were longer and higher in the non-eosinophilic group (P

Published
2015

2. The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia [Corrigendum]

Author

Duman D, Aksoy E, Agca MC, Kocak ND, Ozmen I, Akturk UA, Gungor S, Tepetam FM, Eroglu SA, Oztas S, and Karakurt Z

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Duman D, Aksoy E, Agca MC, et al. International Journal of COPD. 2015;10(1):2469–2478.Page 2475, Table 4, the second column heading “Odds ratio” is incorrect. The correct column heading is “Hazard ratio”. Read the original article

Published
2016

3. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Drewes, A. Mohr, Haas, S.L., Hoyer, B.F., Hampe, J., Hinrichs, C. Noreen, Lerch, M.M., Aghdassi, A.A., Grote, T., Heuser, D.J., Ignatavicius, P., Malecka-Panas, E., Domínguez-Muñoz, J.E., López-Serrano, A., Auriemma, F., Oracz, G., Duman, D., Gubergrits, N., Overbeek, Kasper A., Poulsen, Jakob L., Lanzillotta, Marco, Vinge-Holmquist, Olof, Macinga, Peter, Demirci, A. Fatih, Sindhunata, Daniko P., Backhus, Johanna, Algül, Hana, Buijs, Jorie, Levy, Philippe, Kiriukova, Mariia, Goni, Elisabetta, Hollenbach, Marcus, Miksch, Rainer C., Kunovsky, Lumir, Vujasinovic, Miroslav, Nikolic, Sara, Dickerson, Luke, Hirth, Michael, Neurath, Markus F., Zumblick, Malte, Vila, Josephine, Jalal, Mustafa, Beyer, Georg, Frost, Fabian, Carrara, Silvia, Kala, Zdenek, Jabandziev, Petr, Sisman, Gurhan, Akyuz, Filiz, Capurso, Gabriele, Falconi, Massimo, Arlt, Alexander, Vleggaar, Frank P., Barresi, Luca, Greenhalf, Bill, Czakó, László, Hegyi, Peter, Hopper, Andrew, Nayar, Manu K., Gress, Thomas M., Vitali, Francesco, Schneider, Alexander, Halloran, Chris M., Trna, Jan, Okhlobystin, Alexey V., Dagna, Lorenzo, Cahen, Djuna L., Bordin, Dmitry, Rebours, Vinciane, Mayerle, Julia, Kahraman, Alisan, Rasch, Sebastian, Culver, Emma, Kleger, Alexander, Martínez-Moneo, Emma, Røkke, Ola, Hucl, Tomas, Olesen, Søren S., Bruno, Marco J., Della-Torre, Emanuel, Beuers, Ulrich, Löhr, J.-Matthias, and Rosendahl, Jonas

Published
2024
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4. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Overbeek, Kasper A., primary, Poulsen, Jakob L., additional, Lanzillotta, Marco, additional, Vinge-Holmquist, Olof, additional, Macinga, Peter, additional, Demirci, A. Fatih, additional, Sindhunata, Daniko P., additional, Backhus, Johanna, additional, Algül, Hana, additional, Buijs, Jorie, additional, Levy, Philippe, additional, Kiriukova, Mariia, additional, Goni, Elisabetta, additional, Hollenbach, Marcus, additional, Miksch, Rainer C., additional, Kunovsky, Lumir, additional, Vujasinovic, Miroslav, additional, Nikolic, Sara, additional, Dickerson, Luke, additional, Hirth, Michael, additional, Neurath, Markus F., additional, Zumblick, Malte, additional, Vila, Josephine, additional, Jalal, Mustafa, additional, Beyer, Georg, additional, Frost, Fabian, additional, Carrara, Silvia, additional, Kala, Zdenek, additional, Jabandziev, Petr, additional, Sisman, Gurhan, additional, Akyuz, Filiz, additional, Capurso, Gabriele, additional, Falconi, Massimo, additional, Arlt, Alexander, additional, Vleggaar, Frank P., additional, Barresi, Luca, additional, Greenhalf, Bill, additional, Czakó, László, additional, Hegyi, Peter, additional, Hopper, Andrew, additional, Nayar, Manu K., additional, Gress, Thomas M., additional, Vitali, Francesco, additional, Schneider, Alexander, additional, Halloran, Chris M., additional, Trna, Jan, additional, Okhlobystin, Alexey V., additional, Dagna, Lorenzo, additional, Cahen, Djuna L., additional, Bordin, Dmitry, additional, Rebours, Vinciane, additional, Mayerle, Julia, additional, Kahraman, Alisan, additional, Rasch, Sebastian, additional, Culver, Emma, additional, Kleger, Alexander, additional, Martínez-Moneo, Emma, additional, Røkke, Ola, additional, Hucl, Tomas, additional, Olesen, Søren S., additional, Bruno, Marco J., additional, Della-Torre, Emanuel, additional, Beuers, Ulrich, additional, Löhr, J.-Matthias, additional, Rosendahl, Jonas, additional, Drewes, A. Mohr, additional, Haas, S.L., additional, Hoyer, B.F., additional, Hampe, J., additional, Hinrichs, C. Noreen, additional, Lerch, M.M., additional, Aghdassi, A.A., additional, Grote, T., additional, Heuser, D.J., additional, Ignatavicius, P., additional, Malecka-Panas, E., additional, Domínguez-Muñoz, J.E., additional, López-Serrano, A., additional, Auriemma, F., additional, Oracz, G., additional, Duman, D., additional, and Gubergrits, N., additional

Published
2024
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7. BiallelicKITLGvariants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss

Author

Vona, B., primary, Schwartzbaum, D.A., additional, Rodriguez, A.A., additional, Lewis, S.S., additional, Toosi, M.B., additional, Radhakrishnan, P., additional, Bozan, N., additional, Akın, R., additional, Doosti, M., additional, Manju, R., additional, Duman, D., additional, Sineni, C.J., additional, Nampoothiri, S., additional, Karimiani, E.G., additional, Houlden, H., additional, Bademci, G., additional, Tekin, M., additional, Girisha, K.M., additional, Maroofian, R., additional, and Douzgou, S., additional

Published
2022
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8. Macroporous surgical mesh from a natural cocoon composite

Author

Chen, Y.-M. (Yong-Ming), Zang, L.-S. (Lian-Sheng), Koc-Bilican, B. (Behlul), Bilican, I. (Ismail), Holland, C. (Chris), Cansaran-Duman, D. (Demet), Karaduman, T. (Tugce), Çolak, A. (Arzu), Bayır, Y. (Yasin), Halici, Z. (Zekai), Ozmen, S. (Sevilay), Ali, A. (Asad), Labidi, J. (Jalel), Elbuken, C. (Caglar), Kaya, M. (Murat), Chen, Y.-M. (Yong-Ming), Zang, L.-S. (Lian-Sheng), Koc-Bilican, B. (Behlul), Bilican, I. (Ismail), Holland, C. (Chris), Cansaran-Duman, D. (Demet), Karaduman, T. (Tugce), Çolak, A. (Arzu), Bayır, Y. (Yasin), Halici, Z. (Zekai), Ozmen, S. (Sevilay), Ali, A. (Asad), Labidi, J. (Jalel), Elbuken, C. (Caglar), and Kaya, M. (Murat)

Abstract

Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.

Published
2022

9. Assessment of small airway dysfunction by impulse oscillometry (IOS) in COPD and IPF patients.

Author

DUMAN, D., TAŞTI, Ö. F., and MERVE TEPETAM, F.

Abstract

OBJECTIVE: Small airway dysfunction is a pathological component of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), and impulse oscillometry is an easy-to-administer, effort-independent non-invasive test reflecting small airway dysfunction. We aimed to compare the impulse oscillometry (IOS) measurements between COPD and IPF patients and investigate their correlation with severity of both diseases and other conventional parameters. PATIENTS AND METHODS: This was a prospective, longitudinal study. We longitudinally evaluated the baseline demographic characteristics, COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scale, Pulmonary Function Test (PFT), Carbon Monoxide Diffusing Capacity (DLCO), Hemogram and Impulse Oscillometry measurements of the patients diagnosed with COPD and IPF. RESULTS: The study included 60 IPF patients and 48 COPD patients. The CAT and mMRC scores were higher in COPD patients. The majority of COPD patients were classified into Category B (46%), while 68% of IPF patients had Stage 1 GAP. The mean FEF 25-75%, which is typically considered to reflect small airway disease, was 93% in IPF patients, while it was significantly lower in COPD patients (29%). Impulse oscillometry measurements were consistent with spirometry parameters. IOS resistance and reactance values were significantly higher in COPD patients than in IPF patients. CONCLUSIONS: IOS is advantageous in COPD and IPF patients who cannot exhale due to severe dyspnea, as it is easy to administer and reflects small airway resistance better. Diagnosis of small airway dysfunction may be beneficial in the management of patients with IPF and COPD. [ABSTRACT FROM AUTHOR]

Published
2023

10. Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss.

Author

Vona, B., Schwartzbaum, D.A., Rodriguez, A.A., Lewis, S.S., Toosi, M.B., Radhakrishnan, P., Bozan, N., Akın, R., Doosti, M., Manju, R., Duman, D., Sineni, C.J., Nampoothiri, S., Karimiani, E.G., Houlden, H., Bademci, G., Tekin, M., Girisha, K.M., Maroofian, R., and Douzgou, S.

Subjects
SENSORINEURAL hearing loss, HYPOPIGMENTATION, DISTRIBUTION (Probability theory), HYPERPIGMENTATION, NEURAL crest, HEARING disorders, VITILIGO
Abstract

Background: Pathogenic variants in KITLG, a crucial protein involved in pigmentation and neural crest cell migration, cause non‐syndromic hearing loss, Waardenburg syndrome type 2, familial progressive hyperpigmentation and familial progressive hyper‐ and hypopigmentation, all of which are inherited in an autosomal dominant manner. Objectives: To describe the genotypic and clinical spectrum of biallelic KITLG‐variants. Methods: We used a genotype‐first approach through the GeneMatcher data sharing platform to collect individuals with biallelic KITLG variants and reviewed the literature for overlapping reports. Results: We describe the first case series with biallelic KITLG variants; we expand the known hypomelanosis spectrum to include a 'sock‐and‐glove‐like', symmetric distribution, progressive repigmentation and generalized hypomelanosis. We speculate that KITLG biallelic loss‐of‐function variants cause generalized hypomelanosis, whilst variants with residual function lead to a variable auditory‐pigmentary disorder mostly reminiscent of Waardenburg syndrome type 2 or piebaldism. Conclusions: We provide consolidating evidence that biallelic KITLG variants cause a distinct auditory‐pigmentary disorder. We evidence a significant clinical variability, similar to the one previously observed in KIT‐related piebaldism. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications

Author

Kaya, M. (Murat), Bilican, I. (Ismail), Mujtaba, M. (Muhammad), Sargin, I. (Idris), Haskoylu, M. E. (Merve Erginer), Oner, E. T. (Ebru Toksoy), Zheng, K. (Kai), Boccaccini, A. R. (Aldo R.), Cansaran-Duman, D. (Demet), Onses, M. S. (M. Serdar), Torun, I. (Ilker), Akyuz, L. (Lalehan), Elbuken, C. (Caglar), Sørensen, M. V. (Martin Vinther), Kaya, M. (Murat), Bilican, I. (Ismail), Mujtaba, M. (Muhammad), Sargin, I. (Idris), Haskoylu, M. E. (Merve Erginer), Oner, E. T. (Ebru Toksoy), Zheng, K. (Kai), Boccaccini, A. R. (Aldo R.), Cansaran-Duman, D. (Demet), Onses, M. S. (M. Serdar), Torun, I. (Ilker), Akyuz, L. (Lalehan), Elbuken, C. (Caglar), and Sørensen, M. V. (Martin Vinther)

Abstract

Porous, bioactive microspheres have always been a dream material to biomedical scientists for bone regeneration and drug delivery applications due to their interconnectivity, unique pore geometry, encapsulation ability and porosity spanning macroscopic, microscopic and nanoscopic length scales. Extensive efforts have been made to produce such materials synthetically at a great cost of money, time and labor. Herein, naturally-assembled multifunctional, open-channeled and hollow bioactive micro silica spheres (diameter 209.4 ± 38.5 µm) were discovered in a marine sponge (Geodia macandrewii), by peeling the outer surface of the sterrasters using hydrogen fluoride. The obtained micro silica spheres exhibited valuable characteristics such as homogeneously distributed pores, a cavity in the center of the sphere, and channels (approx. 3000) opening from each pore into the central cavity. Simulated body fluid analysis demonstrated the bioactivity of the micro silica spheres; whereas, no bioactivity was recorded for the original untreated sterrasters. The non-cytotoxicity and osteogenic ability of the isolated microspheres were confirmed through osteoblast cell culture. Finally, these silica based porous microspheres were tested for controlled drug release capacity. The spheres showed excellent loading and release abilities for an anti-cancer drug, carboplatin, in simulated solutions and in human cancer cell culture, HeLa, through a real time cell analyzer system. The drug loading capacity of the porous beads was determined as 10.59%. Considering the unique biological and physicochemical properties, these novel bioactive silica spheres, which we name as giant macroporous silica (GMS), are promising materials for a range of applications including bone tissue engineering and drug delivery.

Published
2021

12. Immunization status in chronic obstructive pulmonary disease: A multicenter study from Turkey

Author

Ozlu, Tevfik, Bulbul, Yilmaz, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, Erboy, Fatma, Koseoglu, Handan Inonu, Anar, Ceyda, Sunnetcioglu, Aysel, Gulhan, Pinar Yildiz, Sahin, Unal, Ekici, Aydanur, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Dalli, A., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Intepe, Y. S., Karadeniz, G., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Kurt, O. K., Arslan, Y., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Erbaycu, A. E., Demir, A., Duman, D., Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., Erel, F., Senyigit, A., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Demirci, N. Y., Bora, M., Talay, F., Ozkara, B., Yilmaz, M. U., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Investigators, R.I.M.P.A.C.T. Study, Acibadem University Dspace, Maltepe Üniversitesi, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Talay, Fahrettin, OMÜ, Tıp Fakültesi, Kırıkkale Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, [Ozlu, Tevfik -- Bulbul, Yilmaz] Karadeniz Tech Univ, Sch Med, Dept Chest Dis, TR-61080 Trabzon, Turkey -- [Aydin, Derya] Pulm Dis Hosp, Chest Dis Clin, Balikesir, Turkey -- [Tatar, Dursun -- Anar, Ceyda] Dr Suat Seren Pulm Dis & Thorac Surg Educ & Res H, Dept Pulm Dis, Izmir, Turkey -- [Kuyucu, Tulin] Sureyyapasa Pulm Dis & Thorac Surg Educ & Res Hos, Dept Pulm Dis, Istanbul, Turkey -- [Erboy, Fatma] Bulent Ecevit Univ, Sch Med, Dept Chest Dis, Zonguldak, Turkey -- [Koseoglu, Handan Inonu] Gaziosmanpasa Univ, Sch Med, Dept Chest Dis, Tokat, Turkey -- [Sunnetcioglu, Aysel] Yuzuncu Yil Univ, Sch Med, Dept Chest Dis, Van, Turkey -- [Gulhan, Pinar Yildiz] Tosya State Hosp, Chest Dis Clin, Kastamonu, Turkey -- [Sahin, Unal] Recep Tayyip Erdogan Univ, Sch Med, Dept Chest Dis, Rize, Turkey -- [Ekici, Aydanur] Kirikkale Univ, Sch Med, Dept Chest Dis, Kirikkale, Turkey -- [Duru, Serap] Diskapi Yildirim Beyazid Educ & Res Hosp, Dept Pulm Dis, Ankara, Turkey -- [Ulasli, Sevinc Sarinc] Hacettepe Univ, Sch Med, Dept Chest Dis, Ankara, Turkey -- [Kurtipek, Ercan] Konya Educ & Res Hosp, Dept Pulm Dis, Konya, Turkey -- [Gunay, Sibel] Afyon State Hosp, Chest Dis Clin, Afyon, Turkey -- [Okutan, O. -- Ayten, O.] Haydarpasa Hosp, Gulhane Mil Med Acad, Dept Chest Dis, Istanbul, Turkey -- [Yildiz, B. P. -- Yazar, E. E. -- Gul, S. -- Bahadir, A. -- Ortakoylu, M. G. -- Bayraktaroglu, M. -- Gunluoglu, G. -- Nizam, M.] Pulm Dis & Thorac Surg Educ & Res Hosp Yedikule, Istanbul, Turkey -- [Cirak, A. K. -- Karadeniz, G. -- Erol, S. -- Erbaycu, A. E. -- Demir, A. -- Yavuz, M. Y. -- Tekgul, S. -- Sever, F. -- Yilmaz, M. U.] Dr Suat Seren, Izmir, Turkey -- [Kocak, N. D. -- Akturk, U. A. -- Arinc, S. -- Sogukpinar, O. -- Duman, D. -- Kasapoglu, U. S.] Sureyyapasa, Istanbul, Turkey -- [Cetinkaya, P. D.] Educ & Res Hosp Numune, Adana, Turkey -- [Dikis, O. S. -- Bora, M.] Sevket Yilmaz, Bursa, Turkey -- [Balaban, A.] Evliya Celebi, Kutahya, Turkey -- [Yuce, G. D.] Diskapi Yildirim Beyazid, Ankara, Turkey -- [Arslan, S. -- Berk, S.] Cumhuriyet Univ, Sch Med, Dept Chest Dis, Sivas, Turkey -- [Sarioglu, N. -- Erel, F.] Balikesir Univ, Balikesir, Turkey -- [Demir, M. -- Senyigit, A.] Dicle Univ, Diyarbakir, Turkey -- [Kilic, T. -- Kaya, S. B.] Inonu Univ, Malatya, Turkey -- [Dalli, A. -- Ayik, S.] Katip Celebi Univ, Izmir, Turkey -- [Altintas, N.] Namik Kemal Univ, Tekirdag, Turkey -- [Acat, M. -- Cortuk, M. -- Yazici, O.] Karabuk Univ, Karabuk, Turkey -- [Dagli, C. E. -- Akgedik, A.] Ordu Univ, Ordu, Turkey -- [Kargi, A. -- Kurt, O. K. -- Yasar, Z. A. -- Talay, F.] Abant Izzet Baysal Univ, Bolu, Turkey -- [Yakar, F. -- Hayat, E.] Bezmialem Vakif Univ, Istanbul, Turkey -- [Kirkil, G.] Firat Univ, Elazig, Turkey -- [Baccioglu, A. -- Bulcun, E. -- Kalpaklioglu, F.] Kirikkale Univ, Kirikkale, Turkey -- [Gedik, C. -- Kanbay, A.] Medeniyet Univ, Istanbul, Turkey -- [Intepe, Y. S.] Bozok Univ, Yozgat, Turkey -- [Sariman, N.] Maltepe Univ, Istanbul, Turkey -- [Ozkurt, S. -- Ugurlu, E.] Pamukkale Univ, Denizli, Turkey -- [Yildirim, Z. -- Demirci, N. Y.] Gazi Univ, Ankara, Turkey -- [Korkmaz, C. -- Yavsan, D. M.] Necmettin Erbakan Univ, Konya, Turkey -- [Erbay, Toru U.] Dumlupinar Univ, Kutahya, Turkey -- [Uzaslan, E. K. -- Cetinoglu, E. D.] Uludag Univ, Bursa, Turkey -- [Baris, S. A. -- Ilgazli, A. H. -- Ciftci, T.] Kocaeli Univ, Kocaeli, Turkey -- [Fidan, F. -- Havan, A.] Fatih Univ, Istanbul, Turkey -- [Guzel, A. -- Gok, A.] Ondokuz Mayis Univ, Samsun, Turkey -- [Alzafer, S.] Acibadem Univ, Bakirkoy Hosp, Istanbul, Turkey -- [Erginel, M. S.] Osmangazi Univ, Eskisehir, Turkey -- [Tanriverdi, H.] Bulent Ecevit Univ, Zonguldak, Turkey -- [Sertogullarindan, B.] Yuzuncu Yil Univ, Van, Turkey -- [Ozyurt, S.] Recep Tayyip Erdogan Univ, Rize, Turkey -- [Sariaydin, M.] Afyon Kocatepe Univ, Afyon, Turkey -- [Onyilmaz, T. -- Sarac, P.] State Hosp Mardin, Mardin, Turkey -- [Arslan, Y. -- Ozkara, B.] Etimesgut Mil Hosp, Ankara, Turkey -- [Ugurlu, A. O. -- Balcan, M. B.] Baskent Univ, Istanbul Hosp, Istanbul, Turkey -- [Yaman, N.] Pulm Dis Hosp, Balikesir, Turkey, intepe, yavuz selim -- 0000-0002-5697-5291, Sertogullarindan, Bunyamin -- 0000-0002-1478-1990, and Bulbul, Yilmaz -- 0000-0002-8488-3650

Subjects
Acute Exacerbations, Pulmonary and Respiratory Medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Coverage, pneumococcal vaccine, Exacerbation, disease exacerbation, influenza vaccine, Influenza vaccine, Copd Exacerbation, Self-Reported Influenza, Chronic Obstructive Pulmonary Disease Exacerbation, Latin-American Cities, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Prevalence, medicine, chronic obstructive pulmonary disease exacerbation, Adults, Mass index, 030212 general & internal medicine, Determinants, lcsh:RC705-779, COPD, business.industry, Chronic obstructive pulmonary disease, chronic obstructive pulmonary, Retrospective cohort study, lcsh:Diseases of the respiratory system, Frequency, medicine.disease, Vaccination, 030228 respiratory system, Pneumococcal vaccine, lcsh:RC666-701, Pneumococcal Vaccination, Original Article, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract

WOS: 000455908800007, PubMed ID: 30745939, OBJECTIVE: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey. METHODS: This was a multicenter retrospective cohort study performed in 53 different centers in Turkey. RESULTS: During the study period, 4968 patients were included. COPD was staged as GOLD 1-2-3-4 in 9.0%, 42.8%, 35.0%, and 13.2% of the patients, respectively. Influenza vaccination rate in the previous year was 37.9%; and pneumococcus vaccination rate, at least once during in a life time, was 13.3%. Patients with older age, higher level of education, more severe COPD, and comorbidities, ex-smokers, and patients residing in urban areas had higher rates of influenza vaccination. Multivariate logistic regression analysis showed that advanced age, higher education levels, presence of comorbidities, higher COPD stages, and exacerbation rates were associated with both influenza and pneumococcal vaccination. The number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was 2.73 +/- 2.85 and 0.92 +/- 1.58 per year, respectively. Patients with older age, lower education levels, more severe COPD, comorbid diseases, and lower body mass index and patients who are male and are residing in rural areas and vaccinated for influenza had significantly higher rates of COPD exacerbation. CONCLUSIONS: The rates of influenza and pneumococcal vaccination in COPD patients were quite low, and the number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was high in Turkey. Advanced age, higher education levels, comorbidities, and higher COPD stages were associated with both influenza and pneumococcal vaccination.

Published
2019

13. Tragepraxis und häufige Anwendungsfehler beim Einsatz von textilen Mund-Nasen-Bedeckungen in der Bevölkerung während der COVID-19-Pandemie in Deutschland

Author

Neuwirth, M, Duman, D, Teves, S, Mattner, F, and Otchwemah, R

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund und Stand (inter)nationaler Forschung: Die starken Restriktionen zur Eindämmung der SARS-CoV-2-Infektion während der COVID-19-Pandemie werden momentan unter infektionspräventiven Auflagen schrittweise gelockert und aufgehoben. Zentrale Bestandteile der Transmissionsvorbeugung[zum vollständigen Text gelangen Sie über die oben angegebene URL], 19. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2020
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14. European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations

Author

Lohr, J. -M., Beuers, U., Vujasinovic, M., Alvaro, D., Frokjaer, J. B., Buttgereit, F., Capurso, G., Culver, E. L., De-Madaria, E., Della-Torre, E., Detlefsen, S., Dominguez-Mu~noz, E., Czubkowski, P., Ewald, N., Frulloni, L., Gubergrits, N., Duman, D. G., Hackert, T., Iglesias-Garcia, J., Kartalis, N., Laghi, A., Lammert, F., Lindgren, F., Okhlobystin, A., Oracz, G., Parniczky, A., Mucelli, R. M. P., Rebours, V., Rosendahl, J., Schleinitz, N., Schneider, A., van Bommel, E. F. H., Verbeke, C. S., Vullierme, M. P., Witt, H., Besselink, M. G., Bruno, M. J., Czako, L., Chiaro, M., Filippova, O., Fukuda, A., Gaujoux, S., Hart, P. A., Hegyi, P., Jonas, E., Kahraman, A., Kleger, A., Kuryata, O., Laukkarinen, J., Lerch, M. M., Marchegiani, G., Marschall, H. -U., Matos, C., Molad, Y., Oguz, D., Pukitis, A., Satoi, S., Stone, J. H., Verheij, J., Vries, N., Lohr, J-Matthias, Beuers, Ulrich, Vujasinovic, Miroslav, Alvaro, Domenico, Frokjaer, Jens Brondum, Buttgereit, Frank, Capurso, Gabriele, Culver, Emma L., De-Madaria, Enrique, Della-Torre, Emanuel, Detlefsen, Sonke, Dominguez-Munoz, Enrique, Czubkowski, Piotr, Ewald, Nils, Frulloni, Luca, Gubergrits, Natalya, Duman, Deniz Guney, Hackert, Thilo, Iglesias-Garcia, Julio, Kartalis, Nikolaos, Laghi, Andrea, Lammert, Frank, Lindgren, Fredrik, Okhlobystin, Alexey, Oracz, Grzegorz, Parniczky, Andrea, Mucelli, Raffaella Maria Pozzi, Rebours, Vinciane, Rosendahl, Jonas, Schleinitz, Nicolas, Schneider, Alexander, van Bommel, Eric F. H., Verbeke, Caroline Sophie, Vullierme, Marie Pierre, Witt, Heiko, Besselink, Marc G., Bruno, Marco J., Czako, Laszlo, del Chiaro, Marco, Filippova, Oleksandra, Fukuda, Akihisa, Gaujoux, Sebastien, Hart, Phil A., Hegyi, Peter, Jonas, Eduard, Kahraman, Alisan, Kleger, Alexander, Kuryata, Olexander, Laukkarinen, Johanna, Lerch, Markus M., Marchegiani, Giovanni, Marschal, Hanns-Ulrich, Matos, Celso, Molad, Yair, Oguz, Dilek, Pukitis, Aldis, Satoi, Sohei, Stone, John H., Verheij, Joanne, de Vries, Niek, KKÜ, Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Löhr, Jm, Beuers, U, Vujasinovic, M, Alvaro, D, Frøkjær, Jb, Buttgereit, F, Capurso, G, Culver, El, de-Madaria, E, DELLA TORRE, E, Detlefsen, S, Dominguez-Muñoz, E, Czubkowski, P, Ewald, N, Frulloni, L, Gubergrits, N, Duman, Dg, Hackert, T, Iglesias-Garcia, J, Kartalis, N, Laghi, A, Lammert, F, Lindgren, F, Okhlobystin, A, Oracz, G, Parniczky, A, Mucelli, Rmp, Rebours, V, Rosendahl, J, Schleinitz, N, Schneider, A, van Bommel, Ef, Verbeke, C, Vullierme, Mp, Witt, H, and UEG guideline working, Group.

Subjects
Abdominal pain, IMMUNOGLOBULIN G4-RELATED DISEASE, SERUM IGG4 LEVELS, Medizin, Disease, RC799-869, Severity of Illness Index, immune-related cholangitis, Serology, 0302 clinical medicine, LONG-TERM OUTCOMES, Prednisone, Drug Dosage Calculations, Child, other organ involvement, STEROID-THERAPY, INTERNATIONAL-CONSENSUS, Evidence-Based Medicine, glucocorticoids, Gastroenterology, Induction Chemotherapy, IgG4-related, Diseases of the digestive system. Gastroenterology, PRIMARY SCLEROSING CHOLANGITIS, TYPE-1 AUTOIMMUNE PANCREATITIS, CONSENSUS DIAGNOSTIC-CRITERIA, Europe, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, diabetes mellitus, 030211 gastroenterology & hepatology, medicine.symptom, digestive, autoimmune pancreatitis type 1, Glucocorticoid, Immunosuppressive Agents, medicine.drug, Adult, medicine.medical_specialty, Digestive System Diseases, biomarkers, cancer, disease, Maintenance Chemotherapy, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, FINE-NEEDLE-ASPIRATION, Dose-Response Relationship, Drug, business.industry, EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY, Body Weight, Editorials, Cancer, Guideline, medicine.disease, business
Abstract

Frulloni, Luca/0000-0001-7417-2655; Hart, Phil/0000-0003-4346-6196; Capurso, Gabriele/0000-0002-0019-8753; de-Madaria, Enrique/0000-0002-2412-9541; Lohr, Matthias/0000-0002-7647-198X; Frokjaer, Jens Brondum/0000-0001-8722-0070 WOS:000542363500001 PubMed: 32552502 The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added. National Societies Committee of the United European Gastroenterology (UEG) We gratefully acknowledge the support from the National Societies Committee of the United European Gastroenterology (UEG) for the conduct of these guidelines independent from other sources. No other funding was received.

Published
2020

24. multicenter study from Turkey

Author

Ozlu, T, Bulbul, Y, Aydin, D, Tatar, D, Kuyucu, T, Erboy, F, Koseoglu, HI, Anar, C, Sunnetcioglu, A, Gulhan, PY, Sahin, U, Ekici, A, Duru, S, Ulasli, SS, Kurtipek, E, Gunay, S, Okutan, O, Yildiz, BP, Cetinkaya, PD, Arslan, S, Cakmak, G, Cirak, AK, Sarioglu, N, Kocak, ND, Akturk, UA, Demir, M, Kilic, T, Dalli, A, Hezer, H, Altintas, N, Acat, M, Dagli, CE, Kargi, A, Yakar, F, Kirkil, G, Baccioglu, A, Gedik, C, Intepe, YS, Karadeniz, G, Onyilmaz, T, Saylan, B, Baslilar, S, Sariman, N, Ozkurt, S, Arinc, S, Kanbay, A, Yazar, EE, Yildirim, Z, Kadioglu, EE, Gul, S, Sengul, A, Berk, S, Dikis, OS, Kurt, OK, Arslan, Y, Erol, S, Korkmaz, C, Balaban, A, Erbay, UT, Sogukpinar, O, Uzaslan, EK, Babaoglu, E, Bahadir, A, Baris, SA, Ugurlu, AO, Ilgazli, AH, Fidan, F, Kararmaz, E, Guzel, A, Alzafer, S, Cortuk, M, Hocanli, I, Ortakoylu, MG, Erginel, MS, Yaman, N, Erbaycu, AE, Demir, A, Duman, D, Tanriverdi, H, Yavuz, MY, Sertogullarindan, B, Ozyurt, S, Bulcun, E, Yuce, GD, Sariaydin, M, Ayten, O, Bayraktaroglu, M, Tekgul, S, Erel, F, Senyigit, A, Kaya, SB, Ayik, S, Yazici, O, Akgedik, A, Yasar, ZA, Hayat, E, Kalpaklioglu, F, Sever, F, Sarac, P, Ugurlu, E, Kasapoglu, US, Gunluoglu, G, Demirci, NY, Bora, M, Talay, F, Ozkara, B, Yilmaz, MU, Yavsan, DM, Cetinoglu, ED, Balcan, MB, Ciftci, T, Havan, A, Gok, A, and Nizam, M

Abstract

OBJECTIVE: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey.

Published
2019

27. Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period

Author

Yilmaz, M. U., Erel, F., Senyigit, A., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Ozkara, B., ÖZLÜ, TEVFİK, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, ERBOY, FATMA, İNÖNÜ KÖSEOĞLU, HANDAN, Anar, Ceyda, Sünnetçioğlu, Aysel, Gulhan, Pinar Yildiz, BÜLBÜL, YILMAZ, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Sahin, Unal, EKİCİ, AYDANUR, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Dalli, A., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Karadeniz, G., Intepe, Y. S., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Arslan, Y., Kurt, O. K., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I, Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Erbaycu, A. E., Demir, A., Duman, D., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Demirci, N. Y., Bora, M., Talay, F., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., and BURSAL DURAMAZ, BURCU

Subjects
musculoskeletal diseases, Male, medicine.medical_specialty, Birth weight, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, Medicine, Humans, Orthopedics and Sports Medicine, Hip Dislocation, Congenital, Retrospective Studies, Ultrasonography, 030222 orthopedics, Developmental dysplasia, business.industry, Obstetrics, Infant, Newborn, Gestational age, Retrospective cohort study, Early neonatal period, Duramaz A., BURSAL DURAMAZ B., Bilgili M. G. , -Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period-, JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, cilt.28, ss.107-110, 2019, Pediatrics, Perinatology and Child Health, Gestation, Female, business, 030217 neurology & neurosurgery, Infant, Premature
Abstract

There are only a few studies in the literature investigating the effects of gestational age on developmental dysplasia of the hip. The aim of this study was to investigate the effects of gestational age on hip ultrasound findings in the early neonatal period in preterm newborns born between 30th and 36th weeks of gestational age. Between January 2008 and December 2013, a total of 788 hips of 394 premature newborns with a gestational age of up to 36th weeks who underwent hip ultrasonography in the first week of their life were retrospectively examined. The distribution of roof angles and hip types in terms of sexes was compared between groups. Birth weight, birth height, a, and beta angles were analyzed in terms of the gestational age. The mean gestational age was 33.07 weeks (SD 2.09; between 30th and 36th). Six hundred and seven hips were classified as type I, 154 as type IIa, 21 as type IIc, and 6 as type III. In the 30th week, type IIc hips in females and type III hips in males were statistically significantly higher (P=0.001). In the 34th week, type IIc hips in males were statistically significantly higher than the females (P=0.013). In the 35th week, type IIa hips in females hips were statistically significantly higher than the males (P=0.008). Among all preterm infants, type IIc hips were more common in the 30th, 31st, 32nd, and 34th weeks, whereas type III hips were statistically significantly more common in the 30th week (P=0.0001). The 30th, 31st, 32nd, and 34th weeks of age are gestational ages that should be considered in terms of dysplastic and subluxed hips in premature newborns. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Published
2018

28. Investigation of Effect of Proposed Two-Stage Foam Injection Method and Modified Additive on Workability of Foam Concrete

Author

Rauan Lukpanov, Duman Dyussembinov, Aliya Altynbekova, Serik Yenkebayev, and Adiya Zhumagulova

Subjects
foam concrete, microsilica, post-alcohol bard, blowing agent, X-ray diffraction analysis, microscopic analysis, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

This article presents the results of an investigation of the proposed method and the influence of a modified additive on foam concrete properties. X-ray diffraction analysis showed that the modified additive has a variable mineralogical composition, and the joint use of the components contributes to the synergistic effect, improving the processes of cement hydration. Microscopy of the foam concrete samples showed the presence of microcracks and micropores in samples both with and without the additive. However, the use of the additive significantly reduced their number and size, which indicates an improvement in the structure of the material. The strength values showed that the samples with the additive have high strength. In particular, the strength values of samples of type 3 at different stages of curing exceed those of samples of type 1 by 1.32–1.51 times and samples of type 2 by 1.07–1.10 times. The obtained strength values are 2.82–3.21 MPa for type 1, 3.64–4.04 MPa for type 2, and 4.39–4.84 MPa for type 3, which corresponds to grade D600. The evaluation of water absorption also confirmed the advantages of the proposed method and the additive, significantly reducing the water absorption of the samples and increasing their hydrophobicity. The obtained values of water absorption are 13.8–16.6% for type 1, 13.7–16.1% for type 2, and 9.5–11.2% for type 3.

Published
2024
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29. Elucidating the genetic architecture of Adams-Oliver syndrome in a large European cohort

Author

Meester, J.A.N., Sukalo, M., Schröder, K.C., Schanze, D., Baynam, G., Borck, G., Bramswig, N.C., Duman, D., Gilbert-Dussardier, B., Holder-Espinasse, M., Itin, P., Johnson, D.S., Joss, S., Koillinen, H., McKenzie, F., Morton, J., Nelle, H., Reardon, W., Roll, C., Salih, M.A., Savarirayan, R., Scurr, I., Splitt, M., Thompson, E., Titheradge, H., Travers, C.P., Van Maldergem, L., Whiteford, M., Wieczorek, D., Vandeweyer, G., Trembath, R., Van Laer, L., Loeys, B.L., Zenker, M., Southgate, L., Wuyts, W., Meester, J.A.N., Sukalo, M., Schröder, K.C., Schanze, D., Baynam, G., Borck, G., Bramswig, N.C., Duman, D., Gilbert-Dussardier, B., Holder-Espinasse, M., Itin, P., Johnson, D.S., Joss, S., Koillinen, H., McKenzie, F., Morton, J., Nelle, H., Reardon, W., Roll, C., Salih, M.A., Savarirayan, R., Scurr, I., Splitt, M., Thompson, E., Titheradge, H., Travers, C.P., Van Maldergem, L., Whiteford, M., Wieczorek, D., Vandeweyer, G., Trembath, R., Van Laer, L., Loeys, B.L., Zenker, M., Southgate, L., and Wuyts, W.

Abstract

Adams–Oliver syndrome (AOS) is a rare developmental disorder, characterized by scalp aplasia cutis congenita (ACC) and transverse terminal limb defects (TTLD). Autosomal dominant forms of AOS are linked to mutations in ARHGAP31, DLL4, NOTCH1 or RBPJ, while DOCK6 and EOGT underlie autosomal recessive inheritance. Data on the frequency and distribution of mutations in large cohorts are currently limited. The purpose of this study was therefore to comprehensively examine the genetic architecture of AOS in an extensive cohort. Molecular diagnostic screening of 194 AOS/ACC/TTLD probands/families was conducted using next‐generation and/or capillary sequencing analyses. In total, we identified 63 (likely) pathogenic mutations, comprising 56 distinct and 22 novel mutations, providing a molecular diagnosis in 30% of patients. Taken together with previous reports, these findings bring the total number of reported disease variants to 63, with a diagnostic yield of 36% in familial cases. NOTCH1 is the major contributor, underlying 10% of AOS/ACC/TTLD cases, with DLL4 (6%), DOCK6 (6%), ARHGAP31 (3%), EOGT (3%), and RBPJ (2%) representing additional causality in this cohort. We confirm the relevance of genetic screening across the AOS/ACC/TTLD spectrum, highlighting preliminary but important genotype–phenotype correlations. This cohort offers potential for further gene identification to address missing heritability.

Published
2018

30. Elucidating the genetic architecture of Adams-Oliver syndrome in a large European cohort

Author

Meester, JAN, Sukalo, M, Schroeder, KC, Schanze, D, Baynam, G, Borck, G, Bramswig, NC, Duman, D, Gilbert-Dussardier, B, Holder-Espinasse, M, Itin, P, Johnson, DS, Joss, S, Koillinen, H, McKenzie, F, Morton, J, Nelle, H, Reardon, W, Roll, C, Salih, MA, Savarirayan, R, Scurr, I, Splitt, M, Thompson, E, Titheradge, H, Travers, CP, Van Maldergem, L, Whiteford, M, Wieczorek, D, Vandeweyer, G, Trembath, R, Van Laer, L, Loeys, BL, Zenker, M, Southgate, L, Wuyts, W, Meester, JAN, Sukalo, M, Schroeder, KC, Schanze, D, Baynam, G, Borck, G, Bramswig, NC, Duman, D, Gilbert-Dussardier, B, Holder-Espinasse, M, Itin, P, Johnson, DS, Joss, S, Koillinen, H, McKenzie, F, Morton, J, Nelle, H, Reardon, W, Roll, C, Salih, MA, Savarirayan, R, Scurr, I, Splitt, M, Thompson, E, Titheradge, H, Travers, CP, Van Maldergem, L, Whiteford, M, Wieczorek, D, Vandeweyer, G, Trembath, R, Van Laer, L, Loeys, BL, Zenker, M, Southgate, L, and Wuyts, W

Abstract

Adams-Oliver syndrome (AOS) is a rare developmental disorder, characterized by scalp aplasia cutis congenita (ACC) and transverse terminal limb defects (TTLD). Autosomal dominant forms of AOS are linked to mutations in ARHGAP31, DLL4, NOTCH1 or RBPJ, while DOCK6 and EOGT underlie autosomal recessive inheritance. Data on the frequency and distribution of mutations in large cohorts are currently limited. The purpose of this study was therefore to comprehensively examine the genetic architecture of AOS in an extensive cohort. Molecular diagnostic screening of 194 AOS/ACC/TTLD probands/families was conducted using next-generation and/or capillary sequencing analyses. In total, we identified 63 (likely) pathogenic mutations, comprising 56 distinct and 22 novel mutations, providing a molecular diagnosis in 30% of patients. Taken together with previous reports, these findings bring the total number of reported disease variants to 63, with a diagnostic yield of 36% in familial cases. NOTCH1 is the major contributor, underlying 10% of AOS/ACC/TTLD cases, with DLL4 (6%), DOCK6 (6%), ARHGAP31 (3%), EOGT (3%), and RBPJ (2%) representing additional causality in this cohort. We confirm the relevance of genetic screening across the AOS/ACC/TTLD spectrum, highlighting preliminary but important genotype-phenotype correlations. This cohort offers potential for further gene identification to address missing heritability.

Published
2018

31. Comparison of fluoro and cine coronary angiography: Balancing acceptable outcomes with a reduction in radiation dose

Author

Ayhan Olcay, Guler, E., Karaca, I. O., Omaygenc, M. O., Kizilirmak, F., Olgun, E., Yenipinar, E., Cakmak, H. A., Duman, D., Olcay, A., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Guler, E., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Karaca, I.O., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Omaygenc, M.O., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Kizilirmak, F., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Olgun, E., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Yenipinar, E., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey, Cakmak, H.A., Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey, and Duman, D., Istanbul Medipol University, Department of Cardiology, Istanbul, Turkey

Subjects
cardiovascular system, Fluoroscopy Time, Radiation Safety, Coronary Angiography
Abstract

WOS: 000362273800008 PubMed ID: 25840403 Use of last fluoro hold (LFH) mode in fluoroscopy, which enables the last live image to be saved and displayed, could reduce radiation during percutaneous coronary intervention when compared with cine mode. No previous study compared coronary angiography radiation doses and image quality between LFH and conventional cine mode techniques. Methods. We compared cumulative dose-area product (DAP), cumulative air kerma, fluoroscopy time, contrast use, interobserver variability of visual assessment between LFH angiography, and conventional cine angiography techniques. Forty-six patients were prospectively enrolled into the LFH group and 82 patients into the cine angiography group according to operator decision. Results. Mean cumulative DAP was higher in the cine group vs the LFH group (50058.98 +/- 53542.71 mGy.cm(2) vs 11349.2 +/- 8796.46 mGy.cm(2); P

Published
2015

32. THE PHYSIOLOGICAL AND DNA DAMAGE RESPONSE OF IN THE LICHEN HYPOGYMNIA PHYSODES TO UV AND HEAVY METAL STRESS.

Author

HAMUTOĞLU, R., DERICI, M. K., ARAS, E. S., ASLAN, A., and CANSARAN-DUMAN, D.

Subjects
HEAVY metals, DNA damage, METALLOTHIONEIN, CAROTENOIDS, DNA methyltransferases, HEAVY metal toxicology, DNA fingerprinting, ULTRAVIOLET radiation
Abstract

This work aims to determine the response of Hypogymnia physodes (L.) Nyl. (hooded tube lichen) collected in an unpolluted site (Yenice Forest in Karabük, Turkey) to stress conditions. In the present study, the effect of exposure to different heavy metals (Cd+2, Pb+2, and Cr+6) for different durations and UV radiations dosages on lichen was examined at the physiological and molecular levels. The effects of stress conditions were determined in the case of different parameters concerning heavy metal, protein, chlorophyll, and carotenoid contents and changes in the DNA profiles. According to the results obtained that exposure to heavy metals and UV radiations leads to a physiological response in a concentration and dose-dependent manner through differences in chlorophyll, protein content in heavy metals and UV treated lichen specimen. Furthermore, changes in RAPD assay and DNA methylation analysis showed that homologous nucleotide sequences in the genome from untreated and stress conditions treated lichen specimen showed different band patterns and methylation under heavy metals and UV stress. The results determined that lichen specimen suggest as a possible bioindicator able to measure the biological effects of heavy metal pollution and damage to UV radiation. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Variants in CIB2 cause DFNB48 and not USH1J

Author

Booth, K.T., primary, Kahrizi, K., additional, Babanejad, M., additional, Daghagh, H., additional, Bademci, G., additional, Arzhangi, S., additional, Zareabdollahi, D., additional, Duman, D., additional, El‐Amraoui, A., additional, Tekin, M., additional, Najmabadi, H., additional, Azaiez, H., additional, and Smith, R.J., additional

Published
2018
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35. The Prevalence of β2 Agonist Response in Patients with Non-asthmatic Eosinophilic Bronchitis (NAEB) and Spirometric Differences among Eosinophilic Airway Disorders Associated with Corticosteroid Responsive Chronic Cough

Author

Tepetam, FM, primary, Duman, D, additional, Kocak, N, additional, Balikci, A, additional, Salturk, C, additional, Agca, M, additional, Oruç, Ö, additional, Bulut, I, additional, Afsar, G, additional, and Colakoglu, B, additional

Published
2017
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37. Variations in multiple syndromic deafness genes mimic non-syndromic hearing loss

Author

Loçlar, İlayda, Bademci, G.; Cengiz, F. B.; Foster, J., II; Duman, D.; Sennaroğlu, L.; Diaz-Horta, O.; Atik, T.; Kirazlı, T.; Olgun, L.; Alper, H.; Menendez, I.; Sennaroğlu, G.; Tokgöz-Yılmaz, S.; Guo, S.; Olgun, Y.; Mahdieh, N.; Bonyadi, M.; Bozan, N.; Ayral, A.; Özkınay, F.; Yıldırım-Baylan, M.; Blanton, S. H.; Tekin, M., School of Medicine, Loçlar, İlayda, Bademci, G.; Cengiz, F. B.; Foster, J., II; Duman, D.; Sennaroğlu, L.; Diaz-Horta, O.; Atik, T.; Kirazlı, T.; Olgun, L.; Alper, H.; Menendez, I.; Sennaroğlu, G.; Tokgöz-Yılmaz, S.; Guo, S.; Olgun, Y.; Mahdieh, N.; Bonyadi, M.; Bozan, N.; Ayral, A.; Özkınay, F.; Yıldırım-Baylan, M.; Blanton, S. H.; Tekin, M., and School of Medicine

Abstract

The genetics of both syndromic (SHL) and non-syndromic hearing loss (NSHL) is characterized by a high degree of genetic heterogeneity. We analyzed whole exome sequencing data of 102 unrelated probands with apparently NSHL without a causative variant in known NSHL genes. We detected five causative variants in different SHL genes (SOX10, MITF, PTPN11, CHD7, and KMT2D) in five (4.9%) probands. Clinical re-evaluation of these probands shows that some of them have subtle syndromic findings, while none of them meets clinical criteria for the diagnosis of the associated syndrome (Waardenburg (SOX10 and MITF), Kallmann (CHD7 and SOX10), Noonan/LEOPARD (PTPN11), CHARGE (CHD7), or Kabuki (KMT2D). This study demonstrates that individuals who are evaluated for NSHL can have pathogenic variants in SHL genes that are not usually considered for etiologic studies., National Institute of Health

Published
2016

38. Variations in Multiple Syndromic Deafness Genes Mimic Non-syndromic Hearing Loss

Author

Bademci, G., primary, Cengiz, F. B., additional, Foster II, J., additional, Duman, D., additional, Sennaroglu, L., additional, Diaz-Horta, O., additional, Atik, T., additional, Kirazli, T., additional, Olgun, L., additional, Alper, H., additional, Menendez, I., additional, Loclar, I., additional, Sennaroglu, G., additional, Tokgoz-Yilmaz, S., additional, Guo, S., additional, Olgun, Y., additional, Mahdieh, N., additional, Bonyadi, M., additional, Bozan, N., additional, Ayral, A., additional, Ozkinay, F., additional, Yildirim-Baylan, M., additional, Blanton, S. H., additional, and Tekin, M., additional

Published
2016
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39. What is the neutrophil/lymphocyte ratio in sarcoidosis?

Author

Gungor, S., primary, Akturk, U. A., additional, Yalcinsoy, M., additional, Kocak, N. D., additional, Goksenoglu, N. C., additional, Altunbey, S. A., additional, Bekir, S. A., additional, O., A. A., additional, Sucu, P., additional, Kuver, S. U., additional, Aksoy, E., additional, Duman, D., additional, Agca, M. C., additional, Oztas, S., additional, Akkaya, E., additional, and Karakurt, Z., additional

Published
2016
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40. Variants in <italic>CIB2</italic> cause DFNB48 and not USH1J.

Author

Booth, K. T., Kahrizi, K., Babanejad, M., Daghagh, H., Bademci, G., Arzhangi, S., Zareabdollahi, D., Duman, D., El‐amraoui, A., Tekin, M., Najmabadi, H., Azaiez, H., and Smith, R. J.

Subjects
DEAFNESS, GENETIC mutation, GENETIC pleiotropy, USHER'S syndrome
Abstract

The genetic, mutational and phenotypic spectrum of deafness‐causing genes shows great diversity and pleiotropy. The best examples are the group of genes, which when mutated can either cause non‐syndromic hearing loss (NSHL) or the most common dual sensory impairment, Usher syndrome (USH). Variants in the CIB2 gene have been previously reported to cause hearing loss at the DFNB48 locus and deaf‐blindness at the USH1J locus. In this study, we characterize the phenotypic spectrum in a multiethnic cohort with autosomal recessive non‐syndromic hearing loss (ARNSHL) due to variants in the CIB2 gene. Of the 6 families we ascertained, 3 segregated novel loss‐of‐function (LOF) variants, 2 families segregated missense variants (1 novel) and 1 family segregated a previously reported pathogenic variant in trans with a frameshift variant. This report is the first to show that biallelic LOF variants in CIB2 cause ARNSHL and not USH. In the era of precision medicine, providing the correct diagnosis (NSHL vs USH) is essential for patient care as it impacts potential intervention and prevention options for patients. Here, we provide evidence disqualifying CIB2 as an USH‐causing gene. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Genetic relationships among some Hesperis L. (Brassicaceae) species from Turkey assessed by RAPD analysis

Author

Aras, S., Duran, A., Yenilmez, G., and Duman, D. C.

Subjects
Hesperis, RAPD, polymorphism, Turkey
Abstract

In this study the phylogenetic relations among infraspecific, specific and supraspecific categories of 6 taxa of the genus Hesperis collected from different parts of Turkey were investigated by RAPD analysis. The results of the RAPD analysis support the idea that H. bicuspidata (Sect. Hesperis), H. schischkinii (Sect. Mediterranea), H. pendula (Sect. Pachycarpos), H. breviscapa, H. kotschyi (Sect. Cvelevia) and H. cappadocica (Sect. Contorta) species need to be placed into different sections according to morphological characters. On the other hand, the phylogenetic order of the sections according to morphological characters and according to molecular data displayed some differences and evolutionary phylogenetic orders of the sections were redesigned. The phylogenetic relations among species were based on the samples H. breviscapa and H. kotschyi which take place in the same section. The accordance of morphological and molecular similarities was noticed for H. breviscapa and H. kotschyi species. Besides this, infraspecific taxonomic situations of H. schischkinii samples having hairy and glabrous (non-hairy) fruits which show allopatric and sympatric spread were reassessed by RAPD analysis.

Published
2010

44. A Founder Tmie Mutation Is A Frequent Cause Of Hearing Loss In Southeastern Anatolia

Author

Sirmaci, A., Oeztuerkmen-Akay, H., Erbek, S., Incesulu, A., Duman, D., Tasir-Yilmaz, S., Oezdag, H., and Tekin, M.

Abstract

Sirmaci A, ozturkmen-Akay H, Erbek S, Incesulu A, Duman D, Tasir-Yilmaz S, ozdag H, Tekin M. A founder TMIE mutation is a frequent cause of hearing loss in southeastern Anatolia.Clin Genet 2009: 75: 562-567. (C) Blackwell Munksgaard, 2009

Published
2009

47. P577 BENEFICIAL EFFECT OF MULTIDISCIPLINARY APPROACH ON SURVIVAL IN HEPATOCELLULAR CARCINOMA PATIENTS

Author

Kani, H.T., primary, Siykhymbayev, A., additional, Demircan, N., additional, Banzragch, M., additional, Gunes Yegin, E., additional, Bicakci, E., additional, Aydin, Y., additional, Irmak, R., additional, Guney Duman, D., additional, Yumuk, P.F., additional, Dane, F., additional, Turhal, N.S., additional, Bekiroglu, N., additional, and Ozdogan, O.C., additional

Published
2014
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48. Clinical and demographic characteristics of patients with non-alcoholic steatohepatitis: A multicenter study

Author

Sarioglu, M, Akarca, U, Sonsuz, A, Duman, D, Tankut, E, Degertekin, H, Uzunalimoglu, O, Çukurova Üniversitesi, and Ondokuz Mayıs Üniversitesi

Abstract

38th Annual Meeting of the European-Association-for-the-Study-of-the-Liver -- MAR 29-APR 01, 2003 -- ISTANBUL, TURKEY Sonsuz, Prof.Dr.Abdullah/0000-0002-8336-5472; bozdayi, mithat/0000-0002-2785-1804 WOS: 000182174500685 … European Assoc Study Liver

Published
2003

49. Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss

Author

Yariz, K.O., Duman, D., Seco, C.Z., Dallman, J., Huang, M., Peters, T.A., Sirmaci, A., Lu, N., Schraders, M., Skromne, I., Oostrik, J., Diaz-Horta, O., Young, J.I., Tokgoz-Yilmaz, S., Konukseven, O., Shahin, H., Hetterschijt, L., Kanaan, M., Oonk, A.M.M., Edwards, Y.J., Li, H., Atalay, S., Blanton, S., Desmidt, A.A., Liu, X.Z., Pennings, R.J.E., Lu, Z., Chen, Z.Y., Kremer, J.M.J., Tekin, M., Yariz, K.O., Duman, D., Seco, C.Z., Dallman, J., Huang, M., Peters, T.A., Sirmaci, A., Lu, N., Schraders, M., Skromne, I., Oostrik, J., Diaz-Horta, O., Young, J.I., Tokgoz-Yilmaz, S., Konukseven, O., Shahin, H., Hetterschijt, L., Kanaan, M., Oonk, A.M.M., Edwards, Y.J., Li, H., Atalay, S., Blanton, S., Desmidt, A.A., Liu, X.Z., Pennings, R.J.E., Lu, Z., Chen, Z.Y., Kremer, J.M.J., and Tekin, M.

Abstract

Item does not contain fulltext, Hereditary hearing loss is characterized by a high degree of genetic heterogeneity. Here we present OTOGL mutations, a homozygous one base pair deletion (c.1430 delT) causing a frameshift (p.Val477Glufs( *)25) in a large consanguineous family and two compound heterozygous mutations, c.547C>T (p.Arg183( *)) and c.5238+5G>A, in a nonconsanguineous family with moderate nonsyndromic sensorineural hearing loss. OTOGL maps to the DFNB84 locus at 12q21.31 and encodes otogelin-like, which has structural similarities to the epithelial-secreted mucin protein family. We demonstrate that Otogl is expressed in the inner ear of vertebrates with a transcription level that is high in embryonic, lower in neonatal, and much lower in adult stages. Otogelin-like is localized to the acellular membranes of the cochlea and the vestibular system and to a variety of inner ear cells located underneath these membranes. Knocking down of otogl with morpholinos in zebrafish leads to sensorineural hearing loss and anatomical changes in the inner ear, supporting that otogelin-like is essential for normal inner ear function. We propose that OTOGL mutations affect the production and/or function of acellular structures of the inner ear, which ultimately leads to sensorineural hearing loss.

Published
2012

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