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30 results on '"Dun, Yaojun"'

14. Safety and durability of single-stage type I hybrid total aortic arch repair for extensive aortic arch disease: early- and long-term clinical outcomes from a single center and our 10-year of experience

Author

Zhang, Bowen, primary, Wei, Yizhen, additional, Liu, Yanxiang, additional, Lin, Hao, additional, Liang, Shenghua, additional, Dun, Yaojun, additional, Yu, Cuntao, additional, Qian, Xiangyang, additional, Guo, Hongwei, additional, and Sun, Xiaogang, additional

Published
2021
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15. Additional file 1 of Risk factor analysis of clinical outcomes of total aortic arch replacement and frozen elephant trunk with aortic balloon occlusion

Author

Wang, Luchen, Li, Yunfeng, Dun, Yaojun, and Sun, Xiaogang

Abstract

Additional file 1. Supplementary Figure 1: Postoperative chest tube output of the ABO group (left column of each point, n = 130) and the conventional TAR with FET group (right column of each point, n = 230). Each bar represents the percentage of chest tube remaining on each postoperative day (%) and chest tube output is graded by showing different colors. Supplementary Figure 2: Blood coagulation test of the ABO group (n = 130) and the conventional TAR with FET group (n = 230). (A) D-dimer. (B) D-dimer ratio. (C) Fibrinogen degradation product. (D) Fibrinogen degradation product ratio. Table S1: Multivariable analysis of blood product transfusion*.

Published
2021
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29. Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7.

Author

Yin H, Sheng Z, Zhang X, Du Y, Qin C, Liu H, Dun Y, Wang Q, Jin C, Zhao Y, and Xu T

Subjects
Aged, Animals, Cell Line, Tumor, Cell Movement genetics, Cell Proliferation genetics, Cyclin D1 metabolism, Female, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Hepatocyte Nuclear Factor 1-alpha metabolism, Humans, Male, Matrix Metalloproteinase 7 metabolism, Mice, Nude, Prostatic Neoplasms metabolism, Proto-Oncogene Proteins c-myc metabolism, SOXF Transcription Factors metabolism, Xenograft Model Antitumor Assays, Prostatic Neoplasms genetics, Prostatic Neoplasms pathology, SOXF Transcription Factors genetics
Abstract

Sex determining region Y (SRY)-box 18 (SOX18) gene encodes transcription factors that have been recently confirmed to be overexpressed in various human types of cancer and maintain the malignant behavior of cancer cells. However, the role and its potential function in prostate cancer (PCa) has not been demonstrated and the mechanisms of SOX18 involved in tumor progression remain largely unclear. In the present study, the expression of SOX18 was analyzed in 98 PCa and 81 adjacent non-tumor tissues using immunohistochemistry. The data showed that SOX18 was overexpressed in 72 of 98 (73.5%) PCa tissues compared with that in 28 of 81 (34.6%) non-tumor tissues. In addition, the expression of SOX18 was related with the clinical features of patients with PCa. To explore the potential role of SOX18 in PCa cells, Cell Counting Kit-8 (CCK-8), migration, invasion and xenograft assays were performed. Our data showed that knockdown of SOX18 decreased the proliferation, migration and invasion of PCa cells in vitro, in addition to the tumor growth in vivo. Markedly, SOX18 knockdown caused the decreased expression of TCF1, c-Myc, cyclin D1 and MMP-7. In conclusion, SOX18 was overexpressed in PCa and may regulate the malignant capacity of cells via the upregulation of TCF1, c-Myc, cyclin D1 and MMP-7.

Published
2017
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30. [Expression of glycoprotein non-metastatic melanoma protein B in clear-cell renal cell carcinoma and clinical implication thereof].

Author

He C, Qin C, Xu T, Yuan Y, Liu Z, Sheng Z, Hu F, Dun Y, and Wang X

Subjects
Glycoproteins, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Prognosis, Receptors, Fc, Survival Analysis, Carcinoma, Renal Cell, Kidney Neoplasms, Melanoma
Abstract

Objective: To elucidate the glycoprotein non-metastatic melanoma protein B(Gpnmb) expression in clear-cell renal cell carcinoma (ccRCC) and to determine its potential prognostic relevance., Methods: A total of 12 pairs of ccRCC tissue specimens were collected from patients undergoing surgery in our hospital from March 2009 to March 2012. Gpnmb expression were determined by immunohistochemistry and correlated with clinical variables. Survival analysis was carried out for another 43 evaluable patients., Results: The expression level of Gpnmb was significantly higher in metastatic ccRCCs than that in matched primary samples ((6.36±4.01) vs (3.14±2.38) scores, P=0.036). The high expression of Gpnmb was not affected by age, gender, clinical stage and pathological grade (all P>0.05). Kaplan-Meier analysis disclosed significant differences in overall survival for patients with higher and lower average Gpnmb expression levels (P=0.020). Cox regression analysis revealed that a high Gpnmb protein expression level in the tumor cell could be identified as an independent poor prognostic marker of overall survival in ccRCC patients (P=0.049)., Conclusion: Over expression of Gpnmb in tumour cell predicts a poor prognosis of patients with ccRCC.

Published
2015

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