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23 results on '"Dunn, Timothy N."'

2. Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis

Author

Dunn, Timothy N, primary, Cope, Dominique I, additional, Tang, Suni, additional, Sirupangi, Tirupataiah, additional, Parks, Sydney E, additional, Liao, Zian, additional, Yuan, Fei, additional, Creighton, Chad J, additional, Masand, Ramya P, additional, Alpuing Radilla, Linda, additional, Guan, Xiaoming, additional, Detti, Laura, additional, Monsivais, Diana, additional, and Matzuk, Martin M, additional

Published
2024
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4. Vasa previa: a multicenter retrospective cohort study

Author

Erfani, Hadi, Haeri, Sina, Shainker, Scott A., Saad, Antonio F., Ruano, Rodrigo, Dunn, Timothy N., Rezaei, Atefeh, Aalipour, Soroush, Nassr, Ahmed A., Shamshirsaz, Amir A., Vaughn, Micah, Lindsley, William, Spiel, Melissa H., Shazly, Sherif A., Ibirogba, Eniola R., Clark, Steven L., Saade, George R., Belfort, Michael A., and Shamshirsaz, Alireza A.

Published
2019
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14. Mid‐TrimesterCervical Length Screening

Author

Becker, David A., Dunn, Timothy N., Szychowski, Jeff M., and Owen, John

Abstract

To identify whether a poorly developed lower uterine segment (PDLUS) observed during cervical length (CL) screening affects the duration of gestation in women with no prior spontaneous preterm birth (sPTB). A retrospective cohort study of women with a singleton gestation and no prior sPTB, who underwent transvaginal CL screening at our institution. We excluded women with progesterone exposure, major anomalies, and women delivering elsewhere. Women with PDLUS were compared to those with a measured (normal) CL ≥25 mm. Primary outcome: birth gestational age (GA). Secondary outcomes: sPTB <35 and 37 weeks, hospital evaluation for preterm labor without delivery, delivery indication, and mode. A Cox proportional‐hazards survival model considered time from CL scan to delivery. We powered the study to detect a one‐half week difference in birth GA. We included 270 women with PDLUS and 985 women with normal CL. Mean birth GA was 38.9 ± 2.0 weeks with PDLUS versus 38.7 ± 2.4 weeks with normal CL (p = .10). Women with PDLUS were less likely to experience sPTB <37 weeks (1.1% vs 3.6%; p = 0.04). There was no difference in sPTB <35 weeks (0.8% vs 1.7%; p = .25). Hospital evaluation for preterm labor (17% vs 19%; p = .54), delivery indication, and mode were not different. The hazard ratio for earlier birth in women with PDLUS was 0.67 (95% CI 0.46, 0.98; p = .04). We observed no difference in mean GA at birth; however, PDLUS was protective against sPTB <37 weeks and was associated with a lower hazard ratio for earlier birth.

Published
2021
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16. 245: Posterior placentation in morbidly adherent placenta: a nested case-control study of characteristics and outcomes

Author

Salmanian, Bahram, primary, Fox, Karin A., additional, Erfani, Hadi, additional, Bateni, Zhoobin H., additional, Shamshirsaz, Amir A., additional, Dildy, Gary A., additional, Kassir, Elias, additional, Moaddab, Amirhossein, additional, Dunn, Timothy N., additional, Podany, Emily L., additional, Ballas, Jerasimos, additional, Rac, Martha, additional, Espinoza, Jimmy, additional, Diaz-Arrastia, Concepcion, additional, Baker, B Wycke, additional, Cassady, Christopher, additional, Hui, Shiu-Ki R., additional, Teruya, Jun, additional, Bandi, Venkata, additional, Coburn, Michael, additional, Lee, Wesley, additional, Popek, Edwina J., additional, Clark, Steven L., additional, Belfort, Michael A., additional, and Shamshirsaz, Alireza A., additional

Published
2017
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17. 152: Predicting severe pulmonary hypoplasia in lower urinary tract obstruction using fetal lung area

Author

Ruano, Rodrigo, primary, Dunn, Timothy N., additional, Blumenfeld, Yair J., additional, de la Penha, Maria Carmen L.M., additional, Koh, Chester J., additional, Angelo, Joseph, additional, Grimm, Paul, additional, Hintz, Susan R., additional, Roth, David R., additional, Welty, Stephen, additional, Braun, Michael C., additional, and Belfort, Michael A., additional

Published
2017
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18. 724: Morbidly adherent placenta - comparison of characteristics and outcomes between scheduled and unscheduled deliveries managed within a single, multidisciplinary team-based referral center

Author

Erfani, Hadi, primary, Fox, Karin A., additional, Bateni, Zhoobin H., additional, Shamshirsaz, Amir A., additional, Salmanian, Bahram, additional, Dildy, Gary A., additional, Kassir, Elias, additional, Moaddab, Amirhossein, additional, Dunn, Timothy N., additional, Podany, Emily L., additional, Ballas, Jerasimos, additional, Rac, Martha, additional, Espinoza, Jimmy, additional, Diaz-Arrastia, Concepcion, additional, Baker, B Wycke, additional, Cassady, Christopher, additional, Rocky Hui, Shiu-Ki, additional, Teruya, Jun, additional, Bandi, Venkata, additional, Coburn, Michael, additional, Lee, Wesley, additional, Popek, Edwina J., additional, Clark, Steven L., additional, Belfort, Michael A., additional, and Shamshirsaz, Alireza A., additional

Published
2017
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19. 792: Characteristics and outcomes of pregnancies with antenatal diagnosis of placenta previa without suspected morbidly adherent placentation in a tertiary center

Author

Podany, Emily L., primary, Fox, Karin A., additional, Erfani, Hadi, additional, Bateni, Zhoobin H., additional, Shamshirsaz, Amir A., additional, Eppes, Catherine, additional, Salmanian, Bahram, additional, Moaddab, Amirhossein, additional, Kassir, Elias, additional, Dunn, Timothy N., additional, Espinoza, Jimmy, additional, Clark, Steven L., additional, Dildy, Gary A., additional, Belfort, Michael A., additional, and Shamshirsaz, Alireza A., additional

Published
2017
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20. 726: Placenta previa without morbidly adherent placentation: comparison of characteristics and outcomes between scheduled and unscheduled (emergency) deliveries in a tertiary center

Author

Kassir, Elias, primary, Fox, Karin A., additional, Erfani, Hadi, additional, Bateni, Zhoobin H., additional, Shamshirsaz, Amir A., additional, Eppes, Catherine, additional, Salmanian, Bahram, additional, Moaddab, Amirhossein, additional, Podany, Emily L., additional, Dunn, Timothy N., additional, Espinoza, Jimmy, additional, Clark, Steven L., additional, Dildy, Gary A., additional, Belfort, Michael A., additional, and Shamshirsaz, Alireza A., additional

Published
2017
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21. 865: Multidisciplinary team learning in management of morbidly adherent placenta - outcome improvements over time

Author

Erfani, Hadi, primary, Fox, Karin A., additional, Bateni, Zhoobin H., additional, Shamshirsaz, Amir A., additional, Salmanian, Bahram, additional, Dildy, Gary A., additional, Kassir, Elias, additional, Moaddab, Amirhossein, additional, Dunn, Timothy N., additional, Podany, Emily L., additional, Ballas, Jerasimos, additional, Rac, Martha, additional, Espinoza, Jimmy, additional, Diaz-Arrastia, Concepcion R., additional, Baker, B Wycke, additional, Cassady, Christopher, additional, Rocky Hui, Shiu-Ki, additional, Teruya, Jun, additional, Bandi, Venkata, additional, Coburn, Michael, additional, Lee, Wesley, additional, Popek, Edwina J., additional, Clark, Steven L., additional, Belfort, Michael A., additional, and Shamshirsaz, Alireza A., additional

Published
2017
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22. Edwardsiella tardaBacteremia With Tubo-Ovarian Abscess

Author

Gardner, Austin B., Dunn, Timothy N., White, Cameron M., Franco, Ricardo, Buenaventura, Sofia, and Boozer, Margaret

Abstract

Edwardsiella tardainfection is infrequently encountered in humans. Exposure most often occurs through consumption of raw seafood or activities in bodies of fresh or brackish water, and systemic infections can have a high mortality rate. We present the case of a 32-year-old woman who presented with abdominal pain, nausea, vomiting, and diarrhea. She was septic and was started on broad-spectrum antibiotics after cultures were drawn. Imaging showed pyosalpinx/tubo-ovarian abscess that was refractory to systemic antibiotics and ultimately required surgical management. Two blood cultures and an intraoperative abscess culture grew pan-susceptible E. tarda. Postoperatively, the patient's clinical status quickly improved, and she was doing well at her follow-up visit. To the best of our knowledge, cases of E. tardabacteremia in the setting of tubo-ovarian abscess have not previously been reported, and this case is particularly unusual in that the patient is young and without predisposing chronic medical conditions.

Published
2022
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23. Impaired bone morphogenetic protein signaling pathways disrupt decidualization in endometriosis.

Author

Liao Z, Tang S, Jiang P, Geng T, Cope DI, Dunn TN, Guner J, Radilla LA, Guan X, and Monsivais D

Abstract

It is hypothesized that impaired endometrial decidualization contributes to decreased fertility in individuals with endometriosis. To identify the molecular defects that underpin defective decidualization in endometriosis, we subjected endometrial stromal cells from individuals with or without endometriosis to time course in vitro decidualization with estradiol, progesterone, and 8-bromo-cyclic-AMP (EPC) for 2, 4, 6, or 8 days. Transcriptomic profiling identified differences in key pathways between the two groups, including defective bone morphogenetic protein (BMP)/SMAD4 signaling ( ID2, ID3, FST ), oxidate stress response ( NFE2L2, ALOX15, SLC40A1 ), and retinoic acid signaling pathways ( RARRES, RARB, ALDH1B1 ). Genome-wide binding analyses identified an altered genomic distribution of SMAD4 and H3K27Ac in the decidualized stromal cells from individuals without endometriosis relative to those with endometriosis, with target genes enriched in pathways related to signaling by transforming growth factor β (TGFβ), neurotrophic tyrosine kinase receptors (NTRK), and nerve growth factor (NGF)-stimulated transcription. We found that direct SMAD1/5/4 target genes control FOXO, PI3K/AKT, and progesterone-mediated signaling in decidualizing cells and that BMP2 supplementation in endometriosis patient-derived assembloids elevated the expression of decidualization markers. In summary, transcriptomic and genome-wide binding analyses of patient-derived endometrial cells and assembloids identified that a functional BMP/SMAD1/5/4 signaling program is crucial for engaging decidualization., Competing Interests: COMPETING INTERESTS. There are no competing interests to declare.

Published
2023
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