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361 results on '"Duodenal ulcer disease"'

2. Damage Control Surgery for Duodenal Ulcer Bleeding With Massive Hematoma and Perforation Due to Over-the-Scope Clip (OTSC).

Author

Harada K, Kojima D, Yamana I, Seike H, and Fujikawa T

Abstract

Due to the advances in endoscopic technology, surgery for duodenal ulcer (DU) bleeding has decreased, although surgery is still necessary for more complicated cases. The concept of damage control surgery (DCS) has been established in the field of trauma, and a simple surgical approach may be preferable in serious cases such as uncontrolled DU bleeding. We present a successful case of bleeding with massive hematoma and perforation of the duodenum due to an over-the-scope clip that was treated by a less invasive surgical approach with consideration of the DCS., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Harada et al.)

Published
2024
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3. Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia

Author

V. Yu. Rusyaev, D. A. Sheptulin, N. V. Shulpekova, and Yu. O. Shulpekova

Subjects
duodenal ulcer disease, functional dyspepsia, proton pump inhibitors, rabeprazole, Medicine
Abstract

The review aims to provide a contemporary view of the pathogenesis and treatment of the most common duodenum diseases – duodenal ulcer disease (DUD) and functional dyspepsia (FD). Due to its unique structure and functions, the duodenum that anatomically represents the initial section of the small intestine differentiates itself from others. The prevalence of DUD is declining in many Western countries due to the widespread introduction of effective anti-Helicobacter therapy and a significant decrease in the prevalence of H pylori infection. However, the ideas about the poly-biological nature of DUD persists and additional risk factors continue to be studied. DUD is manifested by pain/burning feeling in the epigastric region, as well as by symptoms such as early satiety, epigastric filling after eating in the absence of obvious organic changes in the digestive system. The diagnosis of FD is based on the Rome IV criteria. The duodenum plays an important role in its pathogenesis (disorders of gastric accommodation, motor and visceral hypersensitivity). Most patients with FD have microscopic signs of inflammation of the mucous membrane of the postbulbar part of the duodenum - an increased amount of intraepithelial lymphocytes, eosinophils, and signs of increased permeability of the mucous membrane. In all likelihood, these changes are provoked by infection and / or nutritional factors, as well as by exposure to hydrochloric acid. Proton pump inhibitors (prokinetics in postprandial distress syndrome) form the basis of treatment of peptic ulcer and epigastric pain syndrome; all patients with DUD and dyspepsia syndrome infected with H. pylori receive antihelicobacter therapy. Rabeprazole that is characterized by a long and powerful effect and minimal interaction with the cytochrome 2C19 system stands out from the proton pump inhibitors. Conclusion: acid aggression plays a very important role in the pathogenesis of duodenal ulcers diseases and FD; proton pump inhibitors form the basis for the treatment of such patients both in the form of monotherapy and as part of eradication regimens.

Published
2018
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4. The influence of Helicobacter pylori colonisation density and the mucosal inflammatory response on gastric acid secretion

Author

Mullins, Paul Dominic

Subjects
612, Duodenal ulcer disease
Abstract

The mechanism(s) by which Helicobacter pylori infection alters gastric acid secretion is poorly understood. This thesis describes the history and immunopathology of Helicobacter pylori infection, the control of gastric acid secretion and the relationship between them. Glycol methacrylate resin immunohistochemistry has been applied to gastric mucosal biopsy tissue in order to accurately quantify mucosal inflammatory cell recruitment. Clinical and histochemical techniques have been used to study the influence of gastric antral and body mucosal Helicobacter pylori colonisation density and inflammatory cell response on fasting and gastrin releasing peptide-stimulated acid secretion and gastric acid secretory capacity in infected chronic duodenal ulcer and non-ulcer dyspeptic subjects. There are negative correlations between antral Helicobacter pylori colonisation density and fasting acid secretion and gastric acid secretory capacity in active duodenal ulcer disease and non-ulcer dyspepsia but not in those with inactive duodenal ulcer. Thresholds of bacterial load and acid secretory capacity, in combination, are required for active duodenal ulceration. It is hypothesised that an equilibrium is reached between antral Helicobacter pylori colonisation density and gastric acid secretory capacity in active duodenal ulcer disease. Activity and severity of antral inflammation correlates with gastrin releasing peptide-stimulated acid output in inactive duodenal ulcer disease. The degree of antral inflammation in chronic duodenal ulcer disease increases output with consequent ulcer formation. In Helicobacter pylori-infected non-ulcer dyspeptics increased severity of antral chronic inflammation and activity of inflammatory response in the gastric body is associated with decreased acid secretion which may protect this disease group from duodenal ulcer formation. Differences in mucosal T lymphocyte population recruitment may provide part of the explanation for differences in behaviour of Helicobacter pylori positive duodenal ulcer and non-ulcer dyspeptic subjects with respect to acid secretion.

Published
1999

5. Проблемы язвенной болезни двенадцатиперстной кишки у детей школьного возраста

Author

D. V. Melnik

Subjects
Pediatrics, medicine.medical_specialty, School age child, business.industry, medicine, Duodenal ulcer disease, business
Abstract

Актуальность. В данной статье рассматриваются ситуации, которые сложились на сегодня, с заболеваниями органов пищеварения. В настоящее время эта патология занимает второе место как среди взрослого, так и детского населения. Данную ситуацию можно связать не только с экономической нестабильностью, но и с распространенностью вредных привычек среди детей, пренебрежением здоровым образом жизни и т.п. В дальнейшем эти факторы могут влиять не только на общее состояние здоровья, но и на уменьшение продолжительности жизни. Цель: изучить состояние заболеваний органов пищеварения у детей школьного возраста, в первую очередь – язвенной болезни двенадцатиперстной кишки (ЯБ ДПК). Материалы и методы. Использовался метод семантической оценки научных документов, метод системного и процессного анализа. Результаты. Проанализировав научные работы украинских и зарубежных авторов установлено, что язвенная болезнь двенадцатиперстной кишки встречается в 4-13 раз чаще язвенной болезни желудка. Согласно программе исследования проанализированы распространенность язвенной болезни двенадцатиперстной кишки у детей. Результаты научных исследований по механизмам возникновения и развития ЯБ ДПК, как наиболее выразительной модели психосоматических соотношений, свидетельствуют, что ЯБ ДПК рассматривают не как сумму местных нарушений, развившихся вследствие ацидопептичнои агрессии и влияния H. pylori, а как системное заболевание, в формировании которого принимают участие наследственные, психосоматические, нейровегетативные и другие факторы. Несмотря на ведущую роль H. pylori-инфекции в этиологии ЯБ ДПК, эту патологию рассматривают как многофакторное по этиопатогенезу органическое заболевание, в возникновении, течении и последствиях которого вместе с наследственной предрасположенностью (15-40%) и влиянием различных факторов внешней среды важную роль играют психогенные факторы. Определение факторов риска, выявление их роли в нарушении здоровья человека, а также количественная характеристика зависимостей вредных эффектов от уровней воздействия конкретных факторов позволяет оценить реальную угрозу здоровью населения, проживающего на определенных территориях, и дает объективные основания для осуществления профилактических мероприятий. Выводы. В современной медицинской литературе нет достаточных исследований комплексного показателя состояния здоровья детей школьного возраста. В связи с этим предлагается подход, суть которого заключается в том, что дети школьного возраста представляют специфическую категорию населения, которая должна иметь достаточно высокий уровень здоровья, а значит и высокий уровень работоспособности. Что касается уровня работоспособности, то в наших исследованиях будет предложено рациональный подход к его количественного определения.

Published
2021

6. Laparoscopic Approaches to Ulcer Therapy

Author

Katkhouda, Namir, Giordano, Luca, Manhas, Sharon, MacFadyen, Bruce V., Jr., editor, Arregui, Maurice E., editor, Eubanks, Steve, editor, Olsen, Douglas O., editor, Peters, Jeffrey H., editor, Soper, Nathaniel J., editor, Swanström, Lee L., editor, and Wexner, Steven D., editor

Published
2004
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7. Clinical and endoscopic features and treatment problems in patients with duodenal ulcer after its perforation

Author

L A Liubskaia, I Iu Kolesnikova, and Iu V Grigor'eva

Subjects
duodenal ulcer disease, perforation, antisecretory therapy, 24-hour ph-metry, Medicine
Abstract

AIM: To compare clinical and endoscopic findings and standard therapy results in duodenal ulcer disease (DUD) patients with and without a history of perforated ulcer/MATERIAL AND METHODS: One hundred and thirteen patients with recurrent DUD, including 61 patients with uncomplicated DUD (Group 1) and 52 patients with a history of perforated ulcer (Group 2) were examined. Esophagogastroduodenoscopy (EGDS) and 24-hour pH-metry were performed in addition to physical examination. Ulcer scarring was evaluated during control EGDS/RESULTS: 75% of the patients with uncomplicated DUD were observed to have classical pain syndrome and the pain was milder, more extensive, and food-unrelated in the patients who had sustained perforation. Decreased appetite was more common in uncomplicated DUD (35%). EGDS showed that complicated DUD was accompanied by a significantly higher detection rate of erosive esophagitis (20%), gastritis (52%), duodenitis (25%), multiple ulcers (28%), and larger ulcer sizes. 35% of the patients who had experienced duodenal ulcer perforation exhibited an inadequate antisecretory effect of standard omeprazole doses, which was followed by the increase in ulcer scarring time by an average of 1.2 days/CONCLUSION: In the patients with perforated DUD, the history was typified by less pronounced, more extended, and food-unrelated pain, esophageal and gastroduodenal erosive damages, multiple ulcerative defects, large ulcer sizes than in those with uncomplicated DUD, as well as resistance to standard omeprazole dose in one third of the cases, and delayed ulcer scarring.

Published
2013

11. Cysteine and Serine Proteases in Duodenal Ulcer

Author

Herszényi, L., Farinati, F., Plebani, M., Carraro, P., De Paoli, M., Di Mario, F., Kusstatscher, S., Naccarato, R., Tulassay, Z., Mózsik, Gy., editor, Nagy, L., editor, Pár, A., editor, and Rainsford, K. D., editor

Published
1997
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15. Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease.

Author

Bugaytsova JA, Moonens K, Piddubnyi A, Schmidt A, Edlund JO, Lisiutin G, Brännström K, Chernov YA, Thorel K, Tkachenko I, Sharova O, Vikhrova I, Butsyk A, Shubin P, Chyzhma R, Johansson DX, Marcotte H, Sjöström R, Shevtsova A, Bylund G, Rakhimova L, Lundquist A, Berhilevych O, Kasianchuk V, Loboda A, Ivanytsia V, Hultenby K, Persson MAA, Gomes J, Matos R, Gartner F, Reis CA, Whitmire JM, Merrell DS, Pan-Hammarström Q, Landström M, Oscarson S, D'Elios MM, Agreus L, Ronkainen J, Aro P, Engstrand L, Graham DY, Kachkovska V, Mukhopadhyay A, Chaudhuri S, Karmakar BC, Paul S, Kravets O, Camorlinga M, Torres J, Berg DE, Moskalenko R, Haas R, Remaut H, Hammarström L, and Borén T

Abstract

The majority of the world population carry the gastric pathogen Helicobacter pylori . Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where H. pylori attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of H. pylori carriers. These antibodies block binding of the H. pylori attachment protein BabA by mimicking BabA's binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease., Competing Interests: DECLARATION OF INTERESTS The authors declare the following competing interests: T. Borén and L. Hammarström are founders of Helicure AB and, own the IP-rights to the anti-BabA ABbA-IgG1 (US patent US8025880B2) and own the IP-rights to the gastric cancer vaccine and diagnostics described in the two manuscripts by Bugaytsova et al., 2023 (Patent Application SE 2350423-6).

Published
2023
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16. Closed-Loop Gastric Outlet Obstruction Secondary to Duodenal Ulcer in a Patient With Esophageal Stricture.

Author

Kaur J, Stoukides G, and Amaturo M

Abstract

Closed-loop gastric outlet obstruction (GOO) is a rare complication that results from a mechanical obstruction in the pylorus or duodenum. In the early 1990s, the common cause of GOO was peptic ulcer disease, accounting for 5% to 10% of hospital admissions. Peptic ulcer disease is the disruption of the mucosal integrity in the stomach and duodenum and can be categorized into gastric ulcers and duodenal ulcers. With the treatment for Helicobacter  and the increased use of proton pump inhibitors (PPI), GOO now occurs in fewer than 5% of patients with duodenal ulcer disease and even less in those with gastric ulcer disease. Although the morbidity of duodenal ulcers has been declining in recent years, the incidence of post-bulbar duodenal ulcer (PBDU) remains at a constant 9.33%, primarily due to diagnostic and therapeutic difficulties. Additionally, fewer than 5% of obstructing duodenal ulcers are caused by PBDU, and even fewer are located in the second or third portions of the duodenum. Ulcers located in the distal part of the duodenum raise concern for syndromes associated with hypersecretion of acid, including Zollinger-Ellison syndrome (ZES). The ZES is rare, accounting only for 0.1% of all duodenal ulcers. Here, we present a case where a patient with esophageal stricture developed a rare case of closed-loop GOO secondary to a duodenal ulcer. The patient, initially treated for esophageal perforation, developed an esophageal stricture. The patient was being worked up for ZES and multiple endocrine neoplasia link type 1 (MEN1) syndrome due to his concerning laboratory findings and rare clinical presentation.pylori and the increased use of proton pump inhibitors (PPI), GOO now occurs in fewer than 5% of patients with duodenal ulcer disease and even less in those with gastric ulcer disease. Although the morbidity of duodenal ulcers has been declining in recent years, the incidence of post-bulbar duodenal ulcer (PBDU) remains at a constant 9.33%, primarily due to diagnostic and therapeutic difficulties. Additionally, fewer than 5% of obstructing duodenal ulcers are caused by PBDU, and even fewer are located in the second or third portions of the duodenum. Ulcers located in the distal part of the duodenum raise concern for syndromes associated with hypersecretion of acid, including Zollinger-Ellison syndrome (ZES). The ZES is rare, accounting only for 0.1% of all duodenal ulcers. Here, we present a case where a patient with esophageal stricture developed a rare case of closed-loop GOO secondary to a duodenal ulcer. The patient, initially treated for esophageal perforation, developed an esophageal stricture. The patient was being worked up for ZES and multiple endocrine neoplasia link type 1 (MEN1) syndrome due to his concerning laboratory findings and rare clinical presentation., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Kaur et al.)

Published
2023
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19. Bacteria and Gastrin Release

Author

Calam, J., Goodlad, R. A., Lee, C. Y., Ratcliffe, B., Coates, M. E., Stamp, G. W. H., Wright, N. A., Pajares, José M., editor, Peña, A. Salvador, editor, and Malfertheiner, Peter, editor

Published
1993
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26. Animal Experimentation

Author

Isselhard, W. H., Kusche, J., Troidl, Hans, editor, Spitzer, Walter O., editor, McPeek, Bucknam, editor, Mulder, David S., editor, McKneally, Martin F., editor, Wechsler, Andrew S., editor, and Balch, Charles M., editor

Published
1991
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35. Major trends in the antiulcer drugs market

Author

Yuliya Prozherina, Moscow Remedium, Moscow Dentistry, Nadezhda Pavlova, and Roman Beregovykh

Subjects
medicine.medical_specialty, Ambulatory care, business.industry, Antiulcer drug, Internal medicine, Ulcer disease, medicine, General Materials Science, Pharmacy, business, Duodenal ulcer disease, Omeprazole, medicine.drug
Abstract

Over the past few decades, gastric and duodenal ulcer disease (UD) has remained one of the common reasons for outpatient care [1]. Whereas, the improvement of approaches to the treatment of this pathology and development of effective therapy methods open up new possibilities for patients. This article depicts the main trends in the pharmacy antiulcer drugs market.

Published
2020

38. ASSESSMENT OF COMPLIANCE FACTORS IN PATIENTS WITH DUODENAL ULCER COMPLICATED BY STENOSIS

Author

N. V. KOROCHANSKAYA, V. M. DURLESHTER, A. A. SERDYUK, and M. A. BASENKO

Subjects
medicine.medical_specialty, genetic structures, business.industry, Disease, medicine.disease, Duodenal ulcer disease, compliance, behavioral disciplines and activities, Comorbidity, Duodenal ulcer, Dispensary, Stenosis, medicine.anatomical_structure, nervous system, Internal medicine, medicine, Duodenum, Medicine, duodenal ulcer, business, psychological phenomena and processes
Abstract

Aim.This study was conducted to assess the compliance of patients with duodenal ulcer disease during the dispensary observation.Materials and methods.We carried out an examination and a prospective observation of 1896 patients with uncomplicated duodenal ulcer and 43 people with sub- and decompensated scar-ulcerative stenosis of the duodenum.Results. The analysis confirmed that the compliance of patients with duodenal ulcer depends on the professional employment of patients, their gender, the level of education, presence of comorbidity, absence of undesirable effects of the taken medication, contact establishment with the patient, and presence of non-adaptive types of attitude to the disease.Conclusion.The interaction between different factors affecting the compliance should be taken into account when planning the tactics of dispensary observation of patients with uncomplicated duodenal ulcer and after eliminating the complications as wel.

Published
2018

39. microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population.

Author

Lario, S., Ramírez-Lázaro, M. J., Aransay, A. M., Lozano, J. J., Montserrat, A., Casalots, Á., Junquera, F., Álvarez, J., Segura, F., Campo, R., and Calvet, X.

Subjects
*MICRORNA, *GASTRITIS, *HELICOBACTER pylori infections, *DUODENAL ulcers, *GASTRIC diseases, *PATIENTS
Abstract

Clin Microbiol Infect Abstract Although the connection of microRNAs (miRNAs) to some diseases is well established, their involvement in chronic infections such as Helicobacter pylori has received less attention. The aim was to compare miRNA expression profiling in patients with duodenal ulcer (DU) due to H. pylori infection with that in infected patients without DU and in uninfected patients. The miRNA expression profile was determined by microarrays in antral mucosal samples from well-characterized dyspeptic patients ( n = 46). The most significant set of miRNAs was subsequently analysed in an independent validation group of patients ( n = 42). Transcripts for IL8, IL12p40, IL12p35 and IL23p19, the signalling molecules MYD88, GATA6, SOCS2 and STAT6 and H. pylori virulence factors cagA and VacA were analysed. Microarray experiments showed that 17 miRNAs were deregulated in the mucosa of H. pylori-infected patients. No significant differences were observed between normal and DU patients. PCR confirmed the up-regulation of miR-9, miR-146a, miR-155 and miR-650 and the down-regulation of miR-96 and miR-204 in the independent validation set of patients. Importantly, miR-9, miR-96, miR-146a and miR-650 expression was specific to chronic-active gastritis. H. pylori-infected patients showed higher levels of IL8 and IL12p40 mRNAs and lower levels of GATA6 and SOCS2 mRNAs. The antral mucosa of patients with non-active or chronic-active gastritis showed significantly lower levels of GATA6, MYD88, SOCS2 and STAT6 mRNAs compared with patients without gastritis. The down-regulation of these factors was not correlated with the expression of any of the validated miRNAs. The exact role of the miRNA changes observed will require further study. [ABSTRACT FROM AUTHOR]

Published
2012
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40. Trithérapie par oméprazole, amoxicilline et clarithromycine dans la maladie ulcéreuse duodénale associée à Helicobacter pylori au Sénégal.

Author

Fall, F., Diagne, A., Ndiaye, B., Ndiaye, A., Diop, Y., Gning, S., Bâ Fall, K., Diagne Guèye, N., Diallo, I., Mbaye, P., and Debonne, J.

Abstract

Copyright of Journal Africain D'Hépato-Gastroentérologie is the property of Lavoisier and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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41. Gastrointestinal Diseases of Foals

Author

Jonathan E. Palmer

Subjects
Diarrhea, medicine.medical_specialty, Gastrointestinal Diseases, animal diseases, Duodenal ulcer disease, Gastroenterology, digestive system, Article, Rotavirus Infections, Internal medicine, biology.animal, parasitic diseases, medicine, Animals, Horses, Stomach Ulcer, Intestinal Diseases, Parasitic, biology, Equine, business.industry, medicine.disease, Anti-Ulcer Agents, digestive system diseases, Anti-Bacterial Agents, Foal, Animals, Newborn, Gastrointestinal disease, Duodenal Ulcer, Horse Diseases, Antacids, medicine.symptom, business
Abstract

Few foals escape gastrointestinal disease during the first weeks of life. Diarrhea is an extremely common problem; fortunately, however, it is usually mild and self-limiting. When it is not, the underlying cause is often an infectious agent, such as rotavirus or Salmonella spp. Our understanding of many of the infectious agents causing neonatal diarrhea is far from complete. Gastric and duodenal ulcers are a less common disease of neonatal foals. There has been an apparent increase in the incidence of ulcer disease in foals during the past few years. The most effective way of decreasing serious gastrointestinal disease in foals is through the use of good management practices. Environmental and dietary stress must be minimized, and good hygienic practices should be followed. Unfortunately, the needs of the neonate are often ignored, while attention is focused on the mare during the breeding season.

Published
2017

42. The prevalence of diseases among children digestive and peptic ulcer disease duodenum – urgent problem of family medicine

Subjects
medicine.medical_specialty, business.industry, Peptic, Public health, Incidence (epidemiology), lcsh:R, Primary health care, lcsh:Medicine, Duodenal ulcer disease, diseases of the digestive system, primary health care, children, family doctor, Child population, Medicine, business, Demography
Abstract

The current state of public health in Ukraine is characterized as a cri sis. The article analyzes the prevalence of digestive diseases among children aged 0–14 and 15–17 inclusive, and studies the medical and social importance of these diseases impact on the most important peri ods of a growth and development of children and the incidence of the duodenal ulcer disease (DUD) among children. The objective: to examine the prevalence of the peptic duodenal ulcer disease among school children in Ukraine in the practice of family doctors. Materials and methods. The method of semantic evaluation of scien tific instruments and the method of systemic and processing analysis. Results. According to the research program, we studied and analyzed the prevalence of DUD in children in all regions of Ukraine. Particular attention was paid to areas in which the study was conducted (Kyiv City and Kyiv region) [1, 2]. There has been a marked increase in ero sive and ulcerative lesions of the duodenum forms that make up 15–16% of gastroduodenal diseases. The frequency of DUD is 1,6±0,1 per 1000 child population. The severe DUD form and a decrease of the effectiveness of a therapy were recognized. Conclusion. The difference prevalence of digestive diseases among children aged 0–14 years and 15–17 years in the regions of Ukraine are statistically significant and indicates a tendency to increase.

Published
2017

43. Parameters of Proliferation and Apoptosis of Epithelial Cells in the Gastric Mucosa in Indigenous and Non-Indigenous Residents of Khakassia with Helicobacter pylori Positive Duodenal Ulcer Disease.

Author

Tsukanov, V., Shtygasheva, O., Vasyutin, A., Amel'chugova, O., Butorin, N., and Ageeva, E.

Subjects
*HELICOBACTER pylori infections, *PEPTIC ulcer, *GASTRIC mucosa, *KHAKASSIANS, *EPITHELIAL cells, *CELL proliferation, *APOPTOSIS
Abstract

We evaluated parameters of apoptosis in the mucosa of the gastric antrum and body of indigenous and non-indigenous residents of Khakassia with duodenal ulcer disease associated with Helicobacter pylori infection. In the gastric antrum, apoptotic index was significantly increased in patients with ulcer disease in comparison with healthy individuals in both populations. The ratio of proliferation index to apoptotic index was lower in patients with ulcer disease in comparison with healthy individuals in both populations. Similar, but less pronounced processes were recorded in the body of the stomach. Significant changes in the parameters of proliferation and apoptosis were noted in the gastric antrum and body of the stomach in both populations, but they were more pronounced in Caucasians in comparison with Khakasses. [ABSTRACT FROM AUTHOR]

Published
2015
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44. Analysis of Helicobacter pylori Prevalence in Chittagong, Bangladesh, Based on PCR and CLO Test

Author

Mohammad Al-Forkan, Md. Abdul Quader, Md. Jibran Alam, Bashudev Rudra, and Abdul Musaweer Habib

Subjects
medicine.medical_specialty, General Chemical Engineering, Population, lcsh:QR1-502, Disease, Duodenal ulcer disease, Bioinformatics, Gastroenterology, lcsh:Microbiology, law.invention, Age and gender, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Medicine, Medical journal, H. pylori 16S rRNA, education, Polymerase chain reaction, Original Research, education.field_of_study, Helicobacter pylori, biology, business.industry, gastric diseases, bacterial infections and mycoses, biology.organism_classification, Gastric Diseases, PCR, CLO test, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business
Abstract

The pathogenic bacterium Helicobacter pylori is a causative agent of gastric diseases in Bangladesh as well as throughout the world. This study aimed at analyzing the prevalence of H. pylori infection among dyspeptic patients in Chittagong, the second most populous city of Bangladesh, using 16S rRNA-based H. pylori-specific Polymerase Chain Reaction and Campylobacter-like organism test. We found that 67% of the population under study was positive for H. pylori infection. Gastric ulcer and duodenal ulcer disease showed statistically significant association with H. pylori infection; however, no association of H. pylori infection was observed in terms of age and gender. This study would play a crucial role in managing H. pylori-induced gastric diseases by understanding the current trend of H. pylori infection in the Chittagong region of Bangladesh.

Published
2016

45. Optimal treatment for duodenal ulcer disease: A cost–decision analysis in Malaysian patients.

Author

Goh, Kl, Cutler, A, Chua, Abs, Ding, Rph, Kandasami, P, Mazlam, Mz, and Raj, Sm

Subjects
*DUODENAL ulcers, *THERAPEUTICS, *COST effectiveness
Abstract

The aim of the present study was to determine the cost-efficiency of different duodenal ulcer disease treatment practices in Malaysia. Six Malaysian gastroenterologists met to discuss the direct costs related to Helicobacter pylori (HP) eradication treatment. Five treatment strategies were compared: (i) histamine H2 receptor antagonists (H2RA), acid suppression therapy for 6 weeks followed by maintenance therapy as needed; (ii) bismuth triple + proton pump inhibitor (PPI), bismuth (120 mg, q.i.d.), metronidazole (400 mg; t.i.d.), tetracycline (500 mg, q.i.d.) for 7 days and PPI, b.i.d., for 7 days; (iii) OAC, omeprazole (20 mg, b.i.d.), amoxycillin (1000 mg, b.i.d.) and clarithromycin (500 mg, b.i.d.) for 7 days; (iv) OMC, omeprazole (20 mg, b.i.d.), metronidazole (400 mg, b.i.d.) and clarithromycin (500 mg, b.i.d.) for 7 days; and (v) OAM, omeprazole (20 mg, b.i.d.), amoxycillin (1000 mg, b.i.d.) and metronidazole (400 mg, b.i.d.) for 7 days. A decision tree model was created to determine which therapy would be the most cost-effective. The model considered eradication rates, resistance to anti-microbial agents, compliance and cost implications of treatment regimens, physician visits and ulcer recurrences during a 1 year time period assumption. The H2RA maintenance therapy was the most expensive treatment at Malaysian Ringgit (MR) 2335, followed by bismuth triple therapy (MR 1839), OMC (MR 1786), OAM (MR 1775) and OAC, being the most cost-effective therapy, at MR 1679. In conclusion, HP eradication therapy is superior to H2RA maintenance therapy in the treatment of duodenal ulcer disease. Of the HP eradication regimens, OAC is the most cost-effective. [ABSTRACT FROM AUTHOR]

Published
1999
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48. Психосоциальные факторы, влияющие на развитие язвенной болезни двенадцатиперстной кишки у детей

Author

D. V. Melnik

Subjects
medicine.medical_specialty, business.industry, Internal medicine, виразкова хвороба дванадцятипалої кишки, фактори ризику, діти шкільного віку, первинна медична допомога, medicine, язвенная болезнь двенадцатиперстной кишки, факторы риска, дети школьного возраста, первичная медицинская помощь, Duodenal ulcer disease, business, Psychosocial, duodenal ulcer disease, risk factors, school-age children, primary health care
Abstract

Актуальность. Проведение анализа социально-экономического положения семей, психологических и характерологических особенностей детей с язвенной болезнью двенадцатиперстной кишки (ЯБ ДПК) порождает у исследователя необходимость подтвердить (или опровергнуть) гипотетически предусмотренные им закономерности, тенденции развития, механизмы детерминации изучаемого явления. Цель исследования: изучение социально-экономического положения семей и психо-характерологических особенностей детей с ЯБ ДПК как фактора прогрессии заболевания и возможных осложнений. Материалы и методы. Информационной базой исследования избраны результаты анкетирования 425 больных детей и их родителей. Анкетирование детей в возрасте от 14 лет проведено с письменного разрешения родителей. Анкетирование осуществлено во время посещения респондентами врачей общей практики – семейных врачей (ВОП-СВ), педиатров в амбулаторно-поликлинических условиях, а также во время стационарного лечения пациентов. Опрос проведен с применением специально разработанной анкеты. В ходе исследования обеспечена сохранность конфиденциальных данных о респондентах. Основным методом исследования был социологический, а также использовались методы сравнения, медико-статистический и процессного анализа. В статье приведены результаты социологических исследований (анализ анкет), а также представлены общие данные о детях школьного возраста, принявших участие в исследовании. Выводы. Результаты данного исследования позволили выделить статистически достоверные факторы риска, которые влияют на результаты возникновения язвенной болезни двенадцатиперстной кишки, что необходимо для определения группы риска с целью проведения профилактической и консультативной работы с данной категорией детей и их семьями. Учет всех факторов риска даст возможность оптимизировать профилактическую составляющую первичной медицинской помощи и улучшить качество здоровья детей школьного возраста., Актуальність. Проведення аналізу соціально-економічного становища сімей, психологічних і характерологічних особливостей дітей з виразковою хворобою дванадцятипалої кишки (ВХ ДПК) породжує у дослідника необхідність підтвердити (або спростувати) гіпотетично передбачені ним закономірності, тенденції розвитку, механізми детермінації досліджуваного явища. Мета дослідження: вивчення соціально-економічного становища сімей і психо-характерологічних особливостей дітей з ВХ ДПК як фактор прогресії захворювання і можливих ускладнень. Матеріали та методи. Інформаційною базою дослідження обрано результати анкетування 425 хворих дітей і їх батьків. Анкетування дітей у віці від 14 років проведено з письмового дозволу батьків. Анкетування здійснено під час відвідування респондентами лікарів загальної практики - сімейних лікарів (ВОП-СВ), педіатрів в амбулаторно-поліклінічних умовах, а також під час стаціонарного лікування пацієнтів. Опитування проведене з застосуванням спеціально розробленої анкети. В ході дослідження забезпечена схоронність конфіденційних даних про респондентів. Основним методом дослідження був соціологічний, а також використовувалися методи порівняння, медико-статистичний і процесного аналізу. У статті наведені результати соціологічних досліджень (аналіз анкет), а також представлені загальні дані про дітей шкільного віку, які взяли участь в дослідженні. Висновки. Результати даного дослідження дозволили виділити статистично достовірні фактори ризику, початковий стан яких впливає на віддалені результати виникнення виразкової хвороби дванадцятипалої кишки, що необхідно для визначення групи ризику з метою проведення профілактичної та консультативної роботи з даною категорією дітей та їх сім'ями. Облік всіх факторів ризику дасть можливість оптимізувати профілактичну складову первинної медичної допомоги та покращити якість здоров'я дітей шкільного віку., Background. An analysis of the socio-economic situation of families, psychological and characterological features of children with duodenal ulcer disease causes the researcher to confirm (or refute) the patterns, development trends, and mechanisms of determination of the phenomenon being studied that are hypothetically provided for them. Purpose: to study of the socio-economic situation of families and psycho-characterological features of children with duodenal ulcer disease as a factor in the progression of the disease and its possible complications. Materials and methods. The results of a survey of 425 sick children and their parents were the information base of the study. Questioning of children aged 14 and over was conducted with the written permission of their parents. The survey was carried out during respondents visit to general practitioners - family doctors, pediatricians in outpatient settings, as well as during inpatient treatment of patients. The survey was conducted using a specially designed questionnaire. The study ensured the safety of confidential respondents’ data. The main method of research was sociological, and also methods of comparison, medical-statistical and process analysis were used. The article reveals the results of sociological research (analysis of the questionnaires), and also presents general data on school-age children who took part in the study. Conclusions. The results of the study enable to identify statistically significant risk factors, which affects the results of the occurrence of duodenal ulcer disease that is necessary to determine the risk group of children and their families in order to carry out preventive and counseling work. Accounting for all risk factors will provide an opportunity to optimize the preventive component of primary health care and improve the quality of health of school-age children.

Published
2018

49. Evolution of incidence, mortality and cost of nontraumatic abdominal emergencies treated in Brasil in a period of nine years

Author

Mariana Drigo Alem, Tercio de Campos, and Carolina Maria Barbosa Lemos

Subjects
Abdominal pain, Time Factors, Gastrointestinal Diseases, Cholecystitis, Acute, Disease, Duodenal ulcer disease, 0302 clinical medicine, Patient Admission, Colelitíase, Cholelithiasis, lcsh:R5-920, Mortality rate, Incidence (epidemiology), Cost and cost analysis, Incidence, Stomach ulcer, General Medicine, 030220 oncology & carcinogenesis, Acute appendicitis, Acute Disease, Mortalidade, Acute pancreatitis, 030211 gastroenterology & hepatology, medicine.symptom, lcsh:Medicine (General), Emergency Service, Hospital, Brazil, medicine.medical_specialty, 03 medical and health sciences, Emergências, Internal medicine, medicine, Humans, Úlcera gástrica, Mortality, Custos e análise de custo, Doenças do sistema digestório, Acute diverticulitis, Pancreatopatias, business.industry, Dor abdominal, Length of Stay, medicine.disease, Pancreatic diseases, digestive system diseases, Abdominal Pain, Pancreatitis, Digestive system diseases, Emergencies, Health Expenditures, business
Abstract

SUMMARY OBJECTIVE: To evaluate the incidence, mortality and cost of non-traumatic abdominal emergencies treated in Brazilian emergency departments. METHODS: This paper used DataSus information from 2008 to 2016 (http://www.tabnet.datasus.gov.br). The number of hospitalizations, costs - AIH length of stay and mortality rates were described in acute appendicitis, acute cholecystitis, acute pancreatitis, acute diverticulitis, gastric and duodenal ulcer, and inflammatory intestinal disease. RESULTS: The disease that had the highest growth in hospitalization was diverticular bowel disease with an increase of 68.2%. For the period of nine years, there were no significant changes in the average length of hospital stay, with the highest increase in gastric and duodenal ulcer with a growth of 15.9%. The mortality rate of gastric and duodenal ulcer disease increased by 95.63%, which is significantly high when compared to the other diseases. All had their costs increased but the one that proportionally had the highest increase in the last nine years was the duodenal and gastric ulcer, with an increase of 85.4%. CONCLUSION: Non-traumatic abdominal emergencies are extremely prevalent. Hence, the importance of having updated and comparative data on the mortality rate, number of hospitalization and cost generated by these diseases to provide better healthcare services in public hospitals. RESUMO OBJETIVO: Avaliar a evolução da Incidência, mortalidade e custo das urgências abdominais não traumáticas atendidas nos serviços de emergência do Brasil durante o período de nove anos. MÉTODOS: Este trabalho utilizou informações do DataSus de 2008 a 2016, (http://www.tabnet.datasus.gov.br). Foram analisados número de internações, valor médio das internações (AIH), valor total das internações, dias de permanência hospitalar e taxa de mortalidade das seguintes doenças: apendicite aguda, colecistite aguda, pancreatite aguda, diverticulite aguda, úlcera gástrica e duodenal, e doença inflamatória intestinal. RESULTADOS: A doença que teve o maior crescimento do número de internações foi a doença diverticular do intestino, com o valor de 68,2%. Ao longo dos nove anos não houve grandes variações da média de permanência hospitalar, sendo que o maior aumento foi o da úlcera gástrica e duodenal, com crescimento de 15,9%. A taxa de mortalidade da doença por úlcera gástrica e duodenal teve um aumento de 95,63%, consideravelmente significante quando comparada com as outras doenças. Todas tiveram seus valores de AIH aumentados, porém, a que proporcionalmente teve o maior aumento nos últimos nove anos foi a úlcera gástrica e duodenal, com um acréscimo de 85,4%. CONCLUSÃO: As urgências abdominais de origem não traumática são de extrema prevalência, por isso a importância em ter dados atualizados e comparativos sobre a taxa de mortalidade, o número de internações e os custos gerados por essas doenças, para melhor planejamento dos serviços públicos de saúde.

Published
2017

50. ELECTRICAL INSTABILITY OF MYOCARDIUM IN YOUNG MEN WITH ARTERIAL HYPERTENSION AND OCCUPATIONAL STRESS

Author

I. V. Osipova, O. N. Antropova, K. I. Shakhmatova, and V. D. Kondakov

Subjects
arterial hypertension, medicine.medical_specialty, business.industry, electrical instability of myocardium, Chronic gastritis, Duodenal ulcer disease, medicine.disease, Gastroenterology, Surgery, stress, RC666-701, Internal medicine, Functional methods, Concomitant, medicine, Diseases of the circulatory (Cardiovascular) system, Circadian rhythm, Electrical instability, Cardiology and Cardiovascular Medicine, business
Abstract

Aim. To evaluate prevalence of electrical instability of the heart in persons with stressogenic professions by a complex evaluation of the parameters of clinical and functional methods of investigation.Material and methods. Totally 154 men included with AH of I-II stages; first group consisted of 78 motormen and their assistants having stressogenic profession, second grup consisted of 76 persons with minimal psychoemotional tension. A clinical and functional investigation was performed.Results. In 1st group "possible existence" of delayed atrial and ventricular potentials was twice and three times (resp.) more prevalent comparing to the 2nd (with p=0,0001 and p=0,0002, resp.). A rigid circadian index in the 1st group was 1,7 times more prevalent (Х2=10,5; p

Published
2014

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