13 results on '"Duplex kidneys"'
Search Results
2. Clinical profile of duplex kidneys in children and its association with vesicoureteric reflux
- Author
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Athiya Perveen K, Shirbin Joe Mathews, and Thomas P Varghese
- Subjects
Duplex kidneys ,Vesicoureteric reflux ,Ureterocele ,Micturating cystourethrogram ,Clinical profile ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Duplex kidney is a relatively common renal anomaly with a wide array of associations. With routine antenatal screening it is increasingly diagnosed these days. With this study, we aim to assess the clinical profile, prevalence of vesicoureteric reflux and highlighting the need for aggressive workup and management in selected cases to prevent further renal damage. Results Fifty-three children with duplex kidneys who attended the department of pediatric surgery at our institution from December 2016 to December 2021 were included in the study. The most common mode of presentation was urinary tract infection (58%). Fifty-three percent had an antenatally detected renal anomaly (out of these 46% were asymptomatic, 33% had UTI and 11% had other symptoms like straining, incontinence and abdominal mass). Sixty-one percent of patients were conservatively managed and 19 patients needed surgical intervention. Ureterocele was the most common condition necessitating surgery. Prevalence of vesicoureteric reflux was 60% and was comparable with other studies. Thirty-six percent of patients had renal scarring. Among the patients with scarring, 84% had VUR and 63% had febrile UTI. Conclusion Duplex kidney though a common congenital anomaly, requires a systematic evaluation to detect its various associations and a structured management protocol according to the associations. It has a high incidence of VUR which is a potentially hazardous condition which can affect the renal function if not evaluated and managed appropriately. Duplex can also be associated with obstructive conditions like PUJO, ureterocele, and ectopic megaureter which can cause rapid deterioration of renal function if not managed early enough. Though majority of the patients need only follow-up and antibiotic prophylaxis, there may be a certain sub group of patients who develop early scarring and need aggressive management. Our study aims to highlight the need to detect such patients early enough to reduce the morbidity.
- Published
- 2023
- Full Text
- View/download PDF
3. The Ureter
- Author
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Mosa, Hazem, Upadhyaya, Vijai D., Sharma, S. P., Mishra, Pankaj, Sinha, Chandrasen K., editor, and Davenport, Mark, editor
- Published
- 2022
- Full Text
- View/download PDF
4. The left ureterocele and stone of calyceal diverticulum in the patient with bilateral incomplete duplex kidneys managed by flexible ureteroscopy: a case report and literature review
- Author
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Yang Pan, Gang Chen, Han Chen, Yunxiao Zhu, and Hualin Chen
- Subjects
Ureterocele ,Stone ,Calyceal diverticulum ,Duplex kidneys ,Flexible ureteroscopy ,Case report ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Duplex kidneys are one of the most common renal congenital abnormalities, mostly asymptomatic and of no clinical significance. There are little reports about the left ureterocele and stone of calyceal diverticulum in patients with bilateral incomplete duplex kidneys managed by flexible ureteroscopy. Case presentation A 69-year-old Chinese woman was presented with left waist pain for 1 month. A preoperative computed tomography (CT) scan and intravenous pyelogram revealed the left ureterocele which located in the left ureterovesical junction, and stone of calyceal diverticulum which located in the upper kidney of left incomplete duplex kidneys. The ureterocele was confirmed in view of ureteroscopy and the holmium laser was used for the resection of ureterocele. It took us a lot of efforts to find out the stone because of diverticular neck stenosis. Fortunately, when diverticular neck stenosis was incised internally by holmium laser, the stone was discovered clearly and removed using the holmium laser and nitinol stone basket through flexible ureteroscopy. A double-J ureteral stent was inserted and remained in place for 1 month. The symptom disappeared postoperatively and no complications were developed during the placement of the stent. There were no stone residents observed on CT scan before removing the ureteral stent 1 month later. Conclusions Flexible ureteroscopy with holmium laser is feasible to manage the ureterocele and calyceal diverticulum stones in patients with bilateral incomplete duplex kidneys in one operation.
- Published
- 2020
- Full Text
- View/download PDF
5. Supernumerary kidneys: a clinical and radiological analysis of nine cases
- Author
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Peter Rehder, Rafael Rehwald, Julia M. Böhm, Astrid E. Grams, Alexander Loizides, Marco Pedrini, Jannik Stühmeier, and Bernhard Glodny
- Subjects
Supernumerary kidneys ,Computed tomography ,Renal variants ,Diagnostic imaging ,Duplex kidneys ,Ureter fissus ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background A supernumerary kidney (SK) is an additional kidney with its own capsule and blood supply that is not fused with the ipsilateral kidney (IK). Because individual case reports indicate a high morbidity rate, the aim of this retrospective study was a detailed analysis of this rare anatomical variant. Methods Our systematic imaging-based search for SKs, conducted in the period from 2000 and to 2017, yielded 9 cases in total (5 men, 4 women; mean age: 51.8 ± 22.8 years). Results The SKs were observed on the right in six and on the left side in three cases. In six subjects (66%) they were located caudal and in three cases (33%) cranial to the ipsilateral kidney. Calculi were found in three (33%) of the renal collecting systems. Five (56%) of the SKs had hydronephrosis grade IV and one SK had recurrent pyelonephritis (11%). Two of the ureters opened into the ipsilateral seminal vesicle (22%). Two (22%) SKs were functional but atrophic. Clinically relevant findings were made in 33% of the IKs: atrophy (n = 2), calculi (n = 1), and reflux with recurrent pyelonephritis (n = 1); another 33% had anatomical anomalies without functional impairment. The correct diagnosis of a SK is possible using CT imaging in all subjects. The prevalence of SK based on CT imaging can be estimated to be 1:26750. Conclusions CT is the method of choice for visualizing SKs. The correct diagnosis is crucial in preventing dispensable surgical procedures and for providing optimal patient treatment and outcome.
- Published
- 2019
- Full Text
- View/download PDF
6. The left ureterocele and stone of calyceal diverticulum in the patient with bilateral incomplete duplex kidneys managed by flexible ureteroscopy: a case report and literature review.
- Author
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Pan, Yang, Chen, Gang, Chen, Han, Zhu, Yunxiao, and Chen, Hualin
- Subjects
DIVERTICULUM ,URETEROSCOPY ,KIDNEYS ,URINARY calculi ,URETER diseases - Abstract
Background: Duplex kidneys are one of the most common renal congenital abnormalities, mostly asymptomatic and of no clinical significance. There are little reports about the left ureterocele and stone of calyceal diverticulum in patients with bilateral incomplete duplex kidneys managed by flexible ureteroscopy.Case Presentation: A 69-year-old Chinese woman was presented with left waist pain for 1 month. A preoperative computed tomography (CT) scan and intravenous pyelogram revealed the left ureterocele which located in the left ureterovesical junction, and stone of calyceal diverticulum which located in the upper kidney of left incomplete duplex kidneys. The ureterocele was confirmed in view of ureteroscopy and the holmium laser was used for the resection of ureterocele. It took us a lot of efforts to find out the stone because of diverticular neck stenosis. Fortunately, when diverticular neck stenosis was incised internally by holmium laser, the stone was discovered clearly and removed using the holmium laser and nitinol stone basket through flexible ureteroscopy. A double-J ureteral stent was inserted and remained in place for 1 month. The symptom disappeared postoperatively and no complications were developed during the placement of the stent. There were no stone residents observed on CT scan before removing the ureteral stent 1 month later.Conclusions: Flexible ureteroscopy with holmium laser is feasible to manage the ureterocele and calyceal diverticulum stones in patients with bilateral incomplete duplex kidneys in one operation. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
7. An unusual double fungal infection of the bladder due to Candida and Cladosporium
- Author
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G.V. KandaSwamy, B. Viswaroop, A. Elangovan, M. Arul, S.V. Kandasami, and G. Gopalakrishnan
- Subjects
Fungal cystitis ,Candida ,Cladosporium ,Storage symptoms ,Sterile pyuria ,Contracted bladder ,Reflux ,Duplex kidneys ,Bladder augmentation ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Fungal cystitis is usually associated with candida species. Most of the cases are asymptomatic and often due to contamination. Following, we describe the case of a young diabetic lady who presented with severe bladder storage symptoms and persistent sterile pyuria. As candida was isolated from the urine, a diagnosis of fungal cystitis was made. Imaging showed a duplex kidney with complete duplication of the ureters on both sides as well as a contracted bladder with small capacity and bilateral grade-3 reflux into the lower-pole moieties. In view of an increasing severity of the symptoms despite an appropriate treatment, it was decided to augment the bladder. The inflamed bladder wall was excised during augmentation. Tissue culture revealed cladosporium.
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- 2015
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8. Urinary tract anomalies associated with high grade primary vesicoureteral reflux.
- Author
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Hunziker, Manuela, Kutasy, Balazs, D'Asta, Federica, and Puri, Prem
- Subjects
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URINARY organ abnormalities , *VESICO-ureteral reflux , *KIDNEY disease treatments , *POSITRON emission tomography , *RADIOISOTOPES , *HYPOSPADIAS - Abstract
Background: Few studies have evaluated the significance of associated urological anomalies in vesicoureteral reflux (VUR). The aim of our study was to determine the incidence of associated urological anomalies in patients with high grade VUR and to assess their impact on renal parenchymal scarring. Methods: We retrospectively reviewed the hospital records of 1,765 consecutive cases diagnosed with high grade VUR (Grade III-V) at our hospital between 1998 and 2010. The diagnosis of VUR was made by a voiding cystourethrogram (VCUG). Renal scarring was evaluated by dimercapto-succinic acid (DMSA) scintigraphy and classified into three groups: mild (focal defects in uptake between 40 and 45%), moderate (uptake of renal radionuclide between 20 and 40%), and severe (shrunken kidney with relative uptake <20%). All associated urological anomalies were diagnosed by ultrasound or VCUG or DMSA scan. Results: Associated urological anomalies were present in 229 (13%) children. There were 87 boys and 142 girls. Duplex kidney was the main associated anomaly occurring in 148 (64.6%) of the 229 patients. Other anomalies were: bladder diverticulum in 29, solitary kidney in 12, ureterocele in 13, hypospadiasis in 11, pelviureteric junction obstruction in 9, malrotated kidney in 3, horseshoe kidney in 2, crossed fused ectopia in 1 and renal cyst in 1. DMSA scan revealed renal scarring in 105 (47.7%) of the 220 children who had a DMSA scan. 75 (50.7%) children with duplex kidneys showed renal scarring. Conclusion: Associated urological anomalies occur commonly in patients with high grade VUR. Our data shows that nearly half of the patients with VUR and associated urological anomalies have renal scarring. Early recognition and treatment of VUR patients with associated urological anomalies may decrease the risk of renal parenchymal damage. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
9. Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT): SOX11 and CAKUT
- Author
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Franz Schaefer, Ernie M.H.F. Bongers, Mansoureh Tabatabaei, Véronique Lefebvre, Kirsten Y. Renkema, Helen McNeill, Wout F.J. Feitz, Haroun Dhib, Herbert Schulz, Michael Wegner, Vladimir M. Kozlov, Elisabeth Sock, Filippo Massa, Yasmine Neirijnck, Albertien M. van Eerde, Nine V A M Knoers, Andreas Schedl, Antoine Reginensi, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), University Medical Center [Utrecht], Radboud University Medical Center [Nijmegen], Cleveland Clinic, Heidelberg University, University of Cologne, Lunenfeld-Tanenbaum Research Institute [Toronto, Canada], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), ANR-09-GENO-027-01, ANR-11-LABX-0028-01, ARC (SL22020605297), Fondation de la Recherche Medicale (FRM, ING20160435020), European Project: 305608,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,EURENOMICS(2012), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
- Subjects
0301 basic medicine ,Sox11 ,Kidney development ,Nephron ,Biology ,Nephrogenic Cord ,medicine.disease_cause ,Duplex Kidney ,03 medical and health sciences ,Transactivation ,All institutes and research themes of the Radboud University Medical Center ,medicine ,Glial cell line-derived neurotrophic factor ,duplex kidneys ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,CAKUT ,Mutation ,Kidney ,nephron ,kidney induction ,030104 developmental biology ,medicine.anatomical_structure ,Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] ,Nephrology ,Cancer research ,biology.protein ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
International audience; Congenital abnormalities of the kidney and the urinary tract (CAKUT) belong to the most common birth defectsin human, but the molecular basis for the majority of CAKUT patients remains unknown. Here we show thatthe transcription factor SOX11 is a crucial regulator of kidney development. SOX11 is expressed in bothmesenchymal and epithelial components of the early kidney anlagen. Deletion of Sox11 in mice causes anextension of the domain expressing Gdnf within rostral regions of the nephrogenic cord and results in duplexkidney formation. On the molecular level SOX11 directly binds and regulates a locus control region of theprotocadherin B cluster. At later stages of kidney development, SOX11 becomes restricted to the intermediatesegment of the developing nephron where it is required for the elongation of Henle’s loop. Finally, mutationanalysis in a cohort of patients suffering from CAKUT identified a series of rare SOX11 variants, one of whichinterferes with the transactivation capacity of the SOX11 protein. Taken together these data demonstrate akey role for SOX11 in normal kidney development and may suggest that variants in this gene predispose toCAKUT in humans
- Published
- 2018
- Full Text
- View/download PDF
10. Supernumerary kidneys: a clinical and radiological analysis of nine cases
- Author
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Astrid E. Grams, Jannik Stühmeier, Bernhard Glodny, Peter Rehder, Alexander Loizides, Marco Pedrini, Rafael Rehwald, Julia M. Böhm, and Apollo - University of Cambridge Repository
- Subjects
Duplex kidneys ,Adult ,Male ,medicine.medical_specialty ,Urology ,Renal variants ,Ureter fissus ,lcsh:RC870-923 ,Kidney ,Duplex Kidney ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Recurrent pyelonephritis ,medicine ,Humans ,Supernumerary ,030212 general & internal medicine ,Hydronephrosis ,Computed tomography ,Aged ,Retrospective Studies ,Supernumerary kidney ,business.industry ,Supernumerary kidneys ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,medicine.anatomical_structure ,Reproductive Medicine ,Diagnostic imaging ,Female ,Kidney Diseases ,Radiology ,business ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery ,Research Article - Abstract
Background A supernumerary kidney (SK) is an additional kidney with its own capsule and blood supply that is not fused with the ipsilateral kidney (IK). Because individual case reports indicate a high morbidity rate, the aim of this retrospective study was a detailed analysis of this rare anatomical variant. Methods Our systematic imaging-based search for SKs, conducted in the period from 2000 and to 2017, yielded 9 cases in total (5 men, 4 women; mean age: 51.8 ± 22.8 years). Results The SKs were observed on the right in six and on the left side in three cases. In six subjects (66%) they were located caudal and in three cases (33%) cranial to the ipsilateral kidney. Calculi were found in three (33%) of the renal collecting systems. Five (56%) of the SKs had hydronephrosis grade IV and one SK had recurrent pyelonephritis (11%). Two of the ureters opened into the ipsilateral seminal vesicle (22%). Two (22%) SKs were functional but atrophic. Clinically relevant findings were made in 33% of the IKs: atrophy (n = 2), calculi (n = 1), and reflux with recurrent pyelonephritis (n = 1); another 33% had anatomical anomalies without functional impairment. The correct diagnosis of a SK is possible using CT imaging in all subjects. The prevalence of SK based on CT imaging can be estimated to be 1:26750. Conclusions CT is the method of choice for visualizing SKs. The correct diagnosis is crucial in preventing dispensable surgical procedures and for providing optimal patient treatment and outcome.
- Published
- 2019
11. Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT)
- Author
-
Neirijnck, Yasmine, Reginensi, Antoine, Renkema, Kirsten, Massa, Filippo, Kozlov, Vladimir, Dhib, Haroun, Bongers, Ernie, Feitz, Wout, van Eerde, Albertien, Lefebvre, Véronique, Knoers, Nine V.A.M., Tabatabaei, Mansoureh, Schulz, Herbert, Mcneill, Helen, Schaefer, Franz, Wegner, Michael, Sock, Elisabeth, Schedl, Andreas, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University Medical Center [Utrecht], Radboud University Medical Center [Nijmegen], Cleveland Clinic, Heidelberg University, University of Cologne, Lunenfeld-Tanenbaum Research Institute [Toronto, Canada], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), ANR-09-GENO-027-01, ANR-11-LABX-0028-01, ARC (SL22020605297), Fondation de la Recherche Medicale (FRM, ING20160435020), European Project: 305608,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,EURENOMICS(2012), Schedl, Andreas, and European Consortium for High-Throughput Research in Rare Kidney Diseases - EURENOMICS - - EC:FP7:HEALTH2012-10-01 - 2017-09-30 - 305608 - VALID
- Subjects
[SDV.BDD] Life Sciences [q-bio]/Development Biology ,Sox11 ,duplex kidneys ,nephron ,kidney induction ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,CAKUT - Abstract
International audience; Congenital abnormalities of the kidney and the urinary tract (CAKUT) belong to the most common birth defectsin human, but the molecular basis for the majority of CAKUT patients remains unknown. Here we show thatthe transcription factor SOX11 is a crucial regulator of kidney development. SOX11 is expressed in bothmesenchymal and epithelial components of the early kidney anlagen. Deletion of Sox11 in mice causes anextension of the domain expressing Gdnf within rostral regions of the nephrogenic cord and results in duplexkidney formation. On the molecular level SOX11 directly binds and regulates a locus control region of theprotocadherin B cluster. At later stages of kidney development, SOX11 becomes restricted to the intermediatesegment of the developing nephron where it is required for the elongation of Henle’s loop. Finally, mutationanalysis in a cohort of patients suffering from CAKUT identified a series of rare SOX11 variants, one of whichinterferes with the transactivation capacity of the SOX11 protein. Taken together these data demonstrate akey role for SOX11 in normal kidney development and may suggest that variants in this gene predispose toCAKUT in humans
- Published
- 2018
- Full Text
- View/download PDF
12. Ureteral clipping for the treatment of a non-functioning upper kidney moiety associated with a massive ureterocele: step-by-step description of a novel technique.
- Author
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Lopes, R.I., Mello, M.F., Koyle, M.A., and Lorenzo, A.J.
- Abstract
The objective of this video is to illustrate feasibility of the ureteral ligation for the treatment of massive ureteroceles associated with non-functioning upper kidney moieties in duplex kidneys. In this video, one case is presented to demonstrate this novel technique. A nine-year-old boy presented with progressive lower urinary tract symptoms. Radiological workup depicted a duplex kidney on the left side with the absence of function on the upper pole and hydroureteronephrosis with a massive ureterocele. Laparoscopic ureteral transection, drainage, and ligation of both extremities of the enlarged ureter (upper pole ureter) were performed. Immediately after ureteral ligation, ultrasonic evidence of ureterocele decompression and improved hydroureteronephrosis was observed. This patient remained asymptomatic without postoperative complications after 3 years. De novo reflux was not observed. Ureteral ligation, as demonstrated in the video, is a good approach for the treatment of massive ureteroceles associated with non-functioning upper kidney moieties in duplex kidneys. Compared with the current standard techniques (incision/puncture), ureteral ligation has the clear advantage of not causing 'de novo reflux' or unsuccessful de-obstruction, and is not as surgically demanding as other reconstructive/ablative techniques. The disadvantage is the need of regular clinical and ultrasonographic follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
13. Supernumerary kidneys: a clinical and radiological analysis of nine cases.
- Author
-
Rehder, Peter, Rehwald, Rafael, Böhm, Julia M., Grams, Astrid E., Loizides, Alexander, Pedrini, Marco, Stühmeier, Jannik, and Glodny, Bernhard
- Subjects
KIDNEYS ,SEMINAL vesicles ,TREATMENT effectiveness ,CASE studies ,SUPERNUMERARY teeth ,PYELONEPHRITIS ,HYDRONEPHROSIS - Abstract
Background: A supernumerary kidney (SK) is an additional kidney with its own capsule and blood supply that is not fused with the ipsilateral kidney (IK). Because individual case reports indicate a high morbidity rate, the aim of this retrospective study was a detailed analysis of this rare anatomical variant.Methods: Our systematic imaging-based search for SKs, conducted in the period from 2000 and to 2017, yielded 9 cases in total (5 men, 4 women; mean age: 51.8 ± 22.8 years).Results: The SKs were observed on the right in six and on the left side in three cases. In six subjects (66%) they were located caudal and in three cases (33%) cranial to the ipsilateral kidney. Calculi were found in three (33%) of the renal collecting systems. Five (56%) of the SKs had hydronephrosis grade IV and one SK had recurrent pyelonephritis (11%). Two of the ureters opened into the ipsilateral seminal vesicle (22%). Two (22%) SKs were functional but atrophic. Clinically relevant findings were made in 33% of the IKs: atrophy (n = 2), calculi (n = 1), and reflux with recurrent pyelonephritis (n = 1); another 33% had anatomical anomalies without functional impairment. The correct diagnosis of a SK is possible using CT imaging in all subjects. The prevalence of SK based on CT imaging can be estimated to be 1:26750.Conclusions: CT is the method of choice for visualizing SKs. The correct diagnosis is crucial in preventing dispensable surgical procedures and for providing optimal patient treatment and outcome. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
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