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4. Preliminary characterization of a novel form of progressive retinal atrophy in the German Spitz dog associated with a frameshift mutation in GUCY2D.

Author

Bortolini, Mariza, Winkler, Paige A., Duque Moreno, Juan Carlos, Teruo Sato, Mario, Valduga Guareschi, Bianca Luiza, Petersen-Jones, Simon M., and Montiani-Ferreira, Fabiano

Subjects
FRAMESHIFT mutation, ATROPHY, OPTICAL coherence tomography, MELANOPSIN, GENETIC mutation, VISION testing
Abstract

Objective: To describe the clinical, preliminary electroretinographic and optical coherence tomography features of a newly identified form of progressive retinal atrophy (PRA) in German Spitzes, and identify the causal gene mutation. Animals: Thirty-three client-owned German Spitz dogs were included. Procedures: All animals underwent a full ophthalmic examination, including vision testing. In addition, fundus photography, ERG, and OCT were performed. A DNA-marker-based association analysis was performed to screen potential candidate genes and the whole genomes of four animals were sequenced. Results: Initial fundus changes were pale papilla and mild vascular attenuation. Oscillatory nystagmus was noted in 14 of 16 clinically affected puppies. Vision was impaired under both scotopic and photopic conditions. Rod-mediated ERGs were unrecordable in all affected dogs tested, reduced cone-mediated responses were present in one animal at 3 months of age and unrecordable in the other affected animals tested. Multiple small retinal bullae were observed in three clinically affected animals (two with confirmed genetic diagnosis). OCT showed that despite loss of function, retinal structure was initially well-preserved, although a slight retinal thinning developed in older animals with the ventral retina being more severely affected. Pedigree analysis supported an autosomal recessive inheritance. A mutation was identified in GUCY2D, which segregated with the disease (NM_001003207.1:c.1598_1599insT; p.(Ser534GlufsTer20)). Human subjects with GUCY2D mutations typically show an initial disconnect between loss of function and loss of structure, a feature recapitulated in the affected dogs in this study. Conclusion: We identified early-onset PRA in the German Spitz associated with a frameshift mutation in GUCY2D. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Anesthesia of toad (Rhinella icterica) premedicated with dextroketamine and morphine for femur ostheosyntesis.

Author

Matos de Lima, Iara Luiza, Biolchi, Juliano, Félix da Silva Mendes, Juliana Caetano, Borges, Isadora Scherer, and Duque Moreno, Juan Carlos

Subjects
PREANESTHETIC medication, SKIN temperature, ANESTHESIA, PULSE oximetry, TOADS, ISOFLURANE, ANESTHETICS
Abstract

Copyright of Acta Veterinaria Brasilica is the property of Acta Veterinaria Brasilica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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8. Laminite crônica em equino - tratamento com uso de ferradura com travessa horizontal e massa epóxi.

Author

Strugava, Lucimara, do Rocio Janiszewski, Jéssica, Carolini Gomes, Anny Raissa, Duarte Lorga, Andressa, Wacheski, Fabio, Deconto, Ivan, Duque Moreno, Juan Carlos, and Triches Dornbusch, Peterson

Abstract

Background: Laminitis is characterized by an inflammation of the laminar structures of the hoof, which results in lamellar degradation of the suspensory apparatus of the distal phalanx. Despite being a common disease in the equine clinic, it is a medical emergency, which can lead the affected animals not return to sports activities. Due to the severity of laminitis and the poor prognosis, the objective was to report the case of a horse with chronic laminitis with sole perforation in all limbs treated with therapeutic shoeing using a type of horseshoe that has a horizontal crossbar and is filled with mass. Fast-drying epoxy, which has its use little described in the literature Case: A 4-year-old Crioula horse, weighing 325 kg, used in long noose competitions, was referred to the Veterinary Hospital of UFPR with chronic laminitis. The animal had reluctance to move, walk on a trestle position, grade V lameness and phalanx rotation of all limbs. The treatment of laminitis was carried out in the field, for two months, which consisted of trimming and shoeing with a horseshoe in the shape of a heart, and due to the failure of the treatment instituted, the patient presented clinical worsening. The treatment in the HV consisted of cleaning the perforated region of the sole with hydrogen peroxide and 10% iodine and dressing with cotton boots with EVA rubber on the sole to provide comfort. Corrective trimming was performed in order to remove excess forceps, lower the heel, and align the distal phalanx with the hoof wall, using a rasp. Orthopedic shoeing was performed with a normal horseshoe with a horizontal crossbar in the central region. The sole was filled with a quick-drying epoxy putty (Poxilina®), with the aim of preventing sole movement, blocking the rotation of the phalanges and improving the concavity of the hoof. Discussion: In chronic laminitis, the signs observed are claudication and deformation of the hoof, flat sole, enlargement of the white line, uneven growth of the hoof wall, hemorrhage in the abaxial white line, cracks in the hoof wall, which are observed parallel to the coronary band, in addition to phalanx rotation; in this clinical case, all these signs were observed. The trimming of horses with laminitis consists of removing the heels and decreasing the dorsal wall of the hoof, in this case, the trimming performed improved the clinical improvement of the animal five days after the procedure. The horseshoe used in the treatment of this animal has the objective of creating a weight-bearing surface on the middle of the sole, close to the tip of the frog, in this way the weight is not on the supporting edge of the clamp and, in this way, it reduces the pressure. over the most affected area. Despite the scarcity of reports on the use of this type of horseshoe, in this case it played a fundamental role in the treatment of laminitis. In this way, it is an alternative that must be taken into account when choosing the treatment, in view of its effectiveness and lower cost when compared to other methods. This case demonstrates the severity of laminitis in all limbs, especially as it presents a perforation of the sole. It is important to highlight that trimming and shoeing performed at the recommended interval (30-45 days) contributes a lot to the success of the treatment and the return of the animal to sports practice. The horseshoe with a horizontal crossbar was effective in the treatment of chronic laminitis of the forelimbs and pelvic limbs in the reported animal, with progressive improvement of the patient who returned to normal daily activities, without the presence of signs of pain or signs of laminitis after treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Correção de deformidade flexural da articulação metacarpofalangeana em uma bezerra.

Author

Smaniotto Compagnoni, Isabelle, Carolini Gomes, Anny Raissa, Brenner Busch Becker, Ana Paula, Paula Rossa, Ana, Strugava, Lucimara, Sperotto Brum, Juliana, Duque Moreno, Juan Carlos, and Triches Dornbusch, Peterson

Abstract

Background: The congenital flexural deformity is common in cattle, often affecting the metacarpophalangeal joint of the thoracic limbs. The deformity may be mild, moderate, or severe, and the therapy depends on the limb’s degree of flexion and the affected joint. In severe deformities, tenotomy of the flexor tendons and desmotomy of the suspensor ligament is recommended. However, this surgical technique may not be sufficient to promote limb extension, and other interventions may be necessary. Thus, the purpose of this report is to describe a technique to correct severe flexural deformities of the metacarpophalangeal joint in calves. Case: A 3-month-old, female, Dutch-bred calf weighing 46 kg was referred for treatment of congenital flexural deformity. On attendance, the patient presented severe deformity in the right thoracic limb and mild in the left thoracic limb both at the height of the metacarpophalangeal joints. During palpation it was possible to notice that the flexor tendons were contracted in both limbs. Radiographic exams were performed to rule out the presence of other diseases, confirming the diagnosis of flexural deformity. The patient was referred to surgery to correct the anatomical anomaly. The animal was submitted to general anesthesia and placed in right lateral decubitus. In the left thoracic limb, an incision was made in the medial region of the metacarpal bone, the tissues were divulsioned until the superficial digital and deep digital flexor tendons were exposed; these structures were sectioned with a scalpel, and the limb was extended, returning to the standard anatomical position. In the right thoracic limb, the same procedure was performed, but during the limb extension test, we observed that the limb remained flexed, we then followed with a second incision and section of the deep digital flexor tendon in the palmar region at the middle phalanx of the lateral and medial digits, with this procedure, the limb extended further. Nevertheless, the procedure was not enough to solve the problem in the right thoracic limb, and the patient needed a second surgical intervention, in which we performed again tenotomy of the flexor tendons and desmotomy of the digital annular, crossed sesamoid, and interdigital phalangiosamoid ligaments, associated to the capsule opening of the capsule from the affected right metacarpophalangeal joint. After this surgery, the patient recovered to the normal anatomical position of the right thoracic limb. The procedures were efficient in achieving the normality of both affected limbs, and the patient recovered without postoperative complications. Discussion: In severe flexural deformities of the metacarpophalangeal joint in bovines, the fetlock’s flexor tendons and suspensory ligament are implicated in the limb contracture. For these cases the chosen treatment is surgery with sequential sectioning of the flexor tendons and the suspensory ligament until the extension of the flexed limb occurs. Although there are reports that confirm the efficacy of this technique, there are cases in which other anatomic structures are involved in the limb contracture. In addition, the desmotomy and tenotomy techniques are not enough to achieve the normality of the affected joint, with the limb remaining flexed, leading to euthanasia of the patient in some cases. In cattle, few reports demonstrate possible techniques for severe contractures of the metacarpophalangeal joint, requiring further studies and new techniques to achieve recovery of these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Hernioplastia com aplicação de tela por laparoscopia em equino com hérnia incisional.

Author

Carolini Gomes, Anny Raissa, Amaral Rosa, Bruna Machado, Duarte Lorga, Andressa, do Rocio Janiszewski, Jéssica, Strugava, Lucimara, Schade, Jackson, Duque Moreno, Juan Carlos, and Triches Dornbusch, Peterson

Abstract

Background: Incisional hernia in the midline can be a consequence of abdominal surgeries, which incidence is around 5.7-18%. Surgical indication occurs in cases of large hernias, and the most common techniques used involve the closing of the musculature in a primary way, with sutures, and the implantation of a mesh on the abdominal wall. Laparoscopic hernioplasty emerged as a less invasive option, showing superiority when compared with open surgical techniques in human medicine, however there are few reports describing this technique in equines. So, the aim of this paper is to report a case of hernioplasty, using laparoscopic mesh, in a horse with midline incisional hernia. Case: A 13-year-old castrated male Brasileiro de Hipismo horse, weighing 415 kg, practitioner of classic equestrian, presented an incisional hernia after 14 days from an exploratory laparotomy surgery realized to treat colic syndrome. After 6 months, the patient was referred to a Veterinary Medicine Teaching Hospital for the correction of the defect in the abdominal wall. During palpation, the animal did not present local pain or other sign of inflammation, and the hernia measured approximately 20 cm in diameter. The animal was submitted to general anesthesia and placed in dorsal decubitus for the hernioplasty surgical procedure. An incision was made in cranial region of the midline, close to the xiphoid to introduce a single port; the abdomen was inflated with CO2 gas (12 mmHg) and the operating table was tilted in order to displace the organs cranially, facilitating the laparoscopic procedure. The abdomen was inspected and the presence of a single adherence could be observed, which was disrupted with endoscopic forceps. The mesh was introduced through the single port incision and anchored to the musculature, using polypropylene 2 following the marking points previously performed on the implant, covering the defect in the abdominal musculature. In the postoperative period, analgesia was instituted with non-steroidal anti-inflammatory drugs, antibiotic therapy with intravenous benzylpenicillin potassium+gentamicin sulfate, and daily dressings. The animal showed pain responsive to the instituted analgesia in the first 24-72 h after surgery. The discharge was established after 18 days of hospitalization with the recommendation of daily dressings and use of compressive bandage until the complete healing of the wound. Postoperative complications resulting from the laparoscopic hernioplasty technique was not observed in this case. The hernia reduction was satisfactory, with a good aesthetic result after five months, when the animal resumed its athletic activities. Discussion: Laparoscopy hernioplasty is poorly described in equine medicine, and there are no reports of this procedure performed in Brazil, however, it is widely used in human medicine with results superior to open hernioplasty techniques. In the present case and in others reported in the literature, the laparoscopic technique proved to be effective in reducing incisional hernias in horses. The animals had good regression of the hernia sac and the aesthetic result was satisfactory, with few post-surgical complications. In studies in which the open hernioplasty technique was used, there was a higher occurrence of complications, in addition to more intense pain resulting from the procedure and later return to athletic activity, demonstrating that the minimally invasive technique by video surgery can be advantageous. [ABSTRACT FROM AUTHOR]

Published
2021
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12. ANESTESIA INALATÓRIA E ANESTESIA TOTAL INTRAVENOSA EM QUATIS - ESTUDO COMPARATIVO.

Author

Fonseca, Ângela Moni, Martins, Sarah Barboza, Dias Bárisson, Janaina, Muehlbauer, Eloisa, Borges, Naida Cristina, and Duque Moreno, Juan Carlos

Subjects
GENERAL anesthesia, NASUA nasua, CARDIOPULMONARY system physiology
Abstract

Copyright of Archives of Veterinary Science is the property of Archives of Veterinary Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

13. Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses.

Author

Franco, Leandro Guimarães, Duque Moreno, Juan Carlos, Teixeira Neto, Antônio Raphael, Souza, Moisés Caetano, and da Silva, Luiz Antônio Franco

Subjects
*TRAMADOL, *NOCICEPTIVE pain, *TREATMENT of horse diseases, *ANALGESICS, *INTRAVENOUS injections, *CLINICAL medicine, *DRUG analysis, *THERAPEUTICS
Abstract

This study assessed the clinical effects and the mechanical antinociceptive potential of intravenous (IV) tramadol in horses.A blinded and randomized study was designed with 7 horses treated with 1 (Tr1), 2 (Tr2) or 3 (Tr3) mg kg-1 of tramadol IV. The heart rate, respiratory rate (fR), arterial pressure, degree of sedation, gastrointestinal motility (GI), behavior changes and the mechanical nociceptive threshold (MNT) were evaluated. The MNT was determined with von Frey device method.Tr3 had a significant increase in their fR and more pronounced behavioral changes than other treatments. The Tr1 showed a significant increase in arterial pressure. The GI reduced significantly, mainly in Tr2. The tramadol did not change the MNT of the horses. The clinical alterations observed with the different treatments were considered mild and transitory, being most evident in Tr2. However the tramadol did not have any analgesic effect with any of the doses evaluated. [ABSTRACT FROM AUTHOR]

Published
2014
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14. ANESTESIA DO EQUINO COM SINDROME DE CÓLICA: RELATO DE CASOS DE PROCEDIMENTOS ANESTÉSICOS EM CAVALOS COM CÓLICA NO HOSPITAL VETERINÁRIO DA UNIVERSIDADE FEDERAL DO PARANÁ ENTRE 2018 E 2020.

Author

Junior Piontkovsky, Robson, Mazur dos Santos, Amanda Aparecida, Luize Bosak, Viviane, Melânia Cristofolini, Mariana, Camargo Fontanela, Marco Aurélio, Dayrell Fagundes, Luiza, Triches Dornbusch, Peterson, and Duque Moreno, Juan Carlos

Abstract

Copyright of Archives of Veterinary Science is the property of Archives of Veterinary Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

15. ANESTESIA PARA CORREÇÃO CIRÚRGICA DA PERSISTÊNCIA DO DUCTO ARTERIOSO EM CÃES: RELATO DE CASOS ENTRE 2015 - 2020.

Author

Luize Bosak, Viviane, Dayrell, Luiza, Da Veiga Argus, Ana Paula, Gonçalves Sousa, Marlos, Triches Dornbusch, Peterson, and Duque Moreno, Juan Carlos

Abstract

Copyright of Archives of Veterinary Science is the property of Archives of Veterinary Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

16. Bioquímica sérica, termografia e biópsia muscular como métodos de diagnóstico de miopatia pós-anestésica em equinos submetidos à anestesia geral

Author

Barcellos, Luíza Costa, 1993, Duque Moreno, Juan Carlos, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Ciências Veterinárias, and Brum, Juliana Sperotto, 1984

Subjects
Pressão arterial, Medicina Veterinária, Cavalos, Biopsia - Musculos, Histologia veterinaria
Abstract

Orientadora: Profª. Drª. Juliana Sperotto Brum Coorientador: Prof. Dr. Juan Carlos Duque Moreno Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciências Veterinárias. Defesa : Curitiba, 08/04/2020 Inclui referências Resumo: A espécie equina possui um maior risco de desenvolver uma grande variedade de complicações anestésicas e associadas ao procedimento, em comparação a outras espécies. Idealmente, a pressão arterial sistêmica média (PAM) deve ser mantida acima de 80 mmHg e a pressão abaixo de 70 mmHg deve ser tratada. O presente trabalho teve como objetivo realizar uma revisão de literatura sobre miopatia pósanestésica (MPA) e em seguida descrever a avaliação de miopatia pós-anestésica através de diferentes métodos de diagnóstico, realizados experimentalmente em equinos saudáveis. Os grupamentos musculares que serão mais afetados na MPA dependem do decúbito do animal, mas de forma geral, os músculos em contato com a superfície são os mais afetados. O diagnóstico é baseado, inicialmente, em sinais clínicos, mas diferentes exames complementares podem ser utilizados. No presente estudo avaliou-se 7 animais, que foram submetidos à anestesia geral, sendo eles divididos em dois grupos, um com PAM mantida em 60 mmHg e outro em 70 mmHg. Realizou-se exames como bioquímico sérico, termografia e biópsia muscular para comparar os resultados entre os grupos e verificar se houve desenvolvimento de (MPA). Após analisar os resultados, foi possível observar que nenhum animal apresentou aumento das enzimas musculares (CK, AST e LDH) em níveis que sugerissem MPA, além disso não houve diferença significativa entre os grupos. Da mesma forma ocorreu com a termografia do glúteo. Quanto à microscopia óptica da amostra muscular, não foram observadas alterações nos animais em nenhum dos grupos. Com isso, podemos concluir que no estudo não houve diferenças entre os grupos, mas sugere-se um estudo maior, devido ao baixo número de animais utilizados. Palavras-chave: Cavalo. Hipotensão. Histologia. Músculo. Abstract: Equine has a higher risk of developing a wide variety of anesthetic and procedure-related complications, compared to other species. Ideally, mean systemic arterial pressure should be maintained above 80 mmHg and pressure below 70 mmHg should be treated. The present study aimed to conduct a literature review about postanesthetic myopathy and then describe the evaluation of post-anesthetic myopathy through different diagnostic methods, performed experimentally in healthy horses. The muscle groups that will be most affected depend on the animal recumbency, but in general, the muscles in contact with the surface are the most affected. The diagnosis is based, initially, on clinical signs, but complementary exams can be used. In the present study, 7 animals were evaluated and submitted to general anesthesia, divided into two groups, one with mean arterial pressure maintained at 60 mmHg and the other at 70 mmHg. Examinations such as serum biochemistry, thermography and muscle biopsy were performed to compare the results between groups and to verify whether there was development of the disturb. After analyzing the results, it was possible to observe that no animal showed an increase in muscle enzymes (CK, AST and LDH) at levels that suggested post-anesthetic myopathy, and there was no significant difference between groups. The same happened with the gluteal thermography. As for the optical microscopy of the muscle sample, there were no alterations in the animals in any of the groups. With that, we can conclude that in the study there were no differences between the groups, but a larger study is suggested, due to the low number of animals used. Keywords: Histology. Horse. Hypotension. Muscle.

Published
2020

17. Associação do bloqueio do plano transverso do abdomên (TAP-block) com o bloqueio do plano serrátil (SP-block) em cadelas submetidas a mastectomia

Author

Freitag, Flávio Augusto Vieira, Fróes, Tilde Rodrigues 1973, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Ciências Veterinárias, and Duque Moreno, Juan Carlos

Subjects
Cirurgia veterinaria, Oncologia, Cães, Medicina Veterinária, Mastectomia, Anestesia e analgesia
Abstract

Orientador: Prof. Dr. Juan Carlos Duque Moreno Coorientadora: Profa. Dra. Tilde Rodrigues Froes Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciências Veterinárias. Defesa : Curitiba, 14/06/2019 Inclui referências: p. 59-64 Resumo: Objetivo Definir pontos de referência e a dispersão de diferentes volumes de injeção para o bloqueio do plano serrátil superficial (SSP block) em cadáveres de cães. Avaliar a analgesia intra e pós-operatória produzida com a associação do TAP block ao SSP block em cadelas submetidas a mastectomia total unilateral. Design experimental Estudos prospectivos, aleatórios, experimentais cadavérico e clínico. Animais Um cadáver de cão formalizado, quinze cadáveres de cães adultos descongelados e trinta e dois cães com neoplasias mamárias. Métodos A parede torácica do cadáver formalizado foi dissecada em um primeiro momento para identificação dos músculos da parede torácica e dos nervos encontrados no plano fascial entre os músculos músculo serrátil ventral torácico e grande dorsal. Em seguida, com um transdutor linear de ultrassom colocado sob a quarta e quinta costela, no nível da articulação do ombro, o bloqueio do SSP foi realizado nos dois hemitórax de 15 cadáveres de cães. Os 30 hemitórax foram distribuídos aleatóriamente para receber 0,3; 0,6; e 1 mL kg-1 de uma solução 1:1 de azul de metileno a 0,5% e ropivacaína a 0,375%. A solução foi depositada no plano fascial entre o músculo serrátil ventral torácico e grande dorsal e após 15 minutos os cadáveres foram dissecados para confirmar a correta localização e avaliar a dispersão da solução. Os cães com tumores mamários foram distribuídos em quatro grupos (n = 8) que receberam meloxicam (MxG), metadona (MtG), TAP block + SSP block (LG), ou todos os tratamentos combinados (TG). A resposta à estimulação nociceptiva foi avaliada durante a cirurgia e as pacientes foram avaliadas antes da pré-medicação e 1, 2, 3, 4, 6, 8, 12, 16, 20 e 24 horas após a extubação pela escala composta de Glasgow (CMPS-SF) e escala visual analógica. Dor foi considerada quando CMPS-SF ? 6 e metadona foi utilizada como resgate. Resultados A principal inervação no plano superficial serrátil são os ramos cutâneos laterais dos nervos intercostais. A taxa de sucesso do SSP block foi de 89.66% (26/29). Para os grupos 0,3; 0,6 e 1 mL kg-1 a dispersão do corante foi de 4,12 ± 1,12; 3,75 ± 0,93 e 5,00 ± 1,32 dermátomos, respectivamente. Não houve diferença significativa entre os grupos. No estudo clínico observou-se que todos os grupos necessitaram de resgate analgésico com fentanil durante a cirurgia. No período pós-operatório o número de animais resgatados nos grupos MxG, LG, TG e MtG foi de 0, 2, 1 e 3, respectivamente, sem diferenças entre grupos. Contudo, o número total de regates foi maior em MtG (15) do que em MxG (0), LG (3) e TG (1) (p = 0,002). Conclusão O SSP block pode ser facilmente realizado em cães e o volume de 0.3 mL kg-1 é suficiente para obter dispersão do anestésico local compatível com o bloqueio dos ramos cutâneos laterais de T1 a T9, conferindo analgesia da parede lateral do tórax em cães. A associação do SSP com o TAP block pode ser utilizada no contexto de analgesia multimodal, para proporcionar analgesia pósoperatória em cadelas submetidas à mastectomia total unilateral. Palavras-chave: Analgesia; anestesia local; cães; cirurgia oncológica; tórax. Abstract: Objective Cadaveric study of landmarks and volume dispersion of superficial serratus plane block (SSP block) in dogs and clinical evaluation of nociceptive and pain stimulation in dogs submitted to mastectomy receiving the association of TAP and SSP block. Study design Prospective experimental randomized cadaveric and clinical study Animals One formaldehyde solution-preserved dog cadaver, fifteen frozen adult dog cadavers and thirty-two dogs with mammary tumors. Methods The formaldehyde cadaver thoracic wall was dissected in the first moment. After that with the ultrasound transducer placed over the fourth and fifth ribs, at the level of the shoulder joint, SSP block was performed 30 times, using different volumes (0.3, 0.6 and 1 mL kg-1) of blue methylene solution, with a needle between the serratus ventralis thoracis and latissimus dorsi muscles. Cadavers were dissected to confirm and evaluate dispersion. Dogs with mammary tumors were divided in four groups (n = 8 each). Analgesia treatment was meloxicam (MxG), or methadone (MtG), or TAP + SSP block (LG), or all them combined (TG). Nociceptive stimulation was evaluated during surgery and patients were evaluated before premedication and at 1, 2, 3, 4, 6, 8, 12, 16, 20 and 24 hours after extubation, with CMPS-SF and VAS. Pain was considered when CMPF-SF scores ? 6 and methadone was used as rescue analgesia. Results The main innervation at the superficial serratus plane were the lateral cutaneous branches of intercostal nerves. SSP block success rate was 89.66% (26/29). For groups 0.3, 0.6 and 1 mL kg-1 dye dermatomal spread was of 4.12 ± 1.12, 3.75 ± 0.93 and 5.00 ± 1.32, respectively. No statistically significant difference was seen between groups. Clinical study results included that all groups needed analgesic rescue during surgery. At postoperative period the number of animals that receive rescue at MxG, LG, TG and MtG was of 0, 2, 1 and 3 respectively, without difference between the groups. However, the total number of rescues was higher at MtG (15) than in MxG (0), LG (3) and TG (1) (p = 0.002). Conclusion SSP block can be easily performed and a volume of 0.3 mL.kg-1 may be sufficient for hemithorax analgesia in dogs. The association of SSP and TAP block may be used in the context of multimodal analgesic protocol, to provide postoperative analgesia in dogs submitted to total unilateral mastectomy. Key-Words: Analgesia; dog; local anaesthesia; thorax; oncology.

Published
2019

18. Variação da pressão de pulso (VPP) e índice de distensibilidade da veia caval caudal (IDVCC) como preditores de responsividade à expansão volêmica em ovelhas submetidas a choque hemorrágico experimental

Author

Muehlbauer, Eloísa, 1991, Fantoni, Denise Tabacchi, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Ciências Veterinárias, and Duque Moreno, Juan Carlos

Subjects
Medicina veterinária, Ovino, Veia cava - Pressão, choque hemorrágico, Ultrassonografia veterinaria
Abstract

Orientador: Prof. Dr. Juan Carlos Duque Moreno Coorientadora: Profª. Drª. Denise Tabacchi Fantoni Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciências Veterinárias. Defesa : Curitiba, 26/03/2018 Inclui referências Resumo: Objetivo: O objetivo deste estudo foi avaliar a viabilidade do índice de distensibilidade da veia cava caudal (IDVCC) como um indicador de responsividade à reposição volêmica em um modelo experimental de choque hemorrágico moderado em ovelhas. Delineamento experimental: Estudo experimental prospectivo. Animais: Sete ovelhas adultas pesando 55,4 ± 9,56 kg (média ± desvio padrão). Métodos: Os animais foram anestesiados com isofluorano e ventilados no modo volume-controlado, com volume corrente de 8 mL kg-1 e bloqueio neuromuscular com atracúrio. Foram avaliadas as variáveis cardiorrespiratórias e hemodinâmicas antes da hemorragia (T0), imediatamente após o fim da exanguinação (TChoque), após a manutenção da pressão arterial média (PAM) em 50 mmHg durante 30 minutos (TChoque30), após cada um de três desafios volêmicos com 10 mL kg-1 de Ringer com lactato (TRes1, TRes2 e TRes3) e após a transfusão do sangue autólogo (TTrans). Também foi determinada a correlação com as alterações no índice cardíaco (IC), a área sob a curva ROC (Receive opating characteristic), a sensibilidade, a especificidade e os valores de corte da variação da pressão de pulso (VPP), IDVCC, da pressão venosa central (PVC), da pressão diastólica da artéria pulmonar (PAPD) e da PAM. Resultados: O modelo induziu as alterações esperadas nas variáveis hemodinâmicas e de oxigenação tecidual e o protocolo de ressuscitação volêmica foi eficiente em reverter essas alterações. A VPP e o IDVCC aumentaram significativamente em relação ao momento T0 após a hemorragia e se normalizaram após o TRes1. A VPP (r = 0,70), o IDVCC (r = 0,64) e a PAM (r = 0,72) apresentaram maior grau de correlação com o IC do que a PVC (r = 0,48, p = 0,00041) e a PAPD (r = 0,36, p = 0,0091). A VPP (AUC = 0,83; p = 0.005) e o IDVCC (AUC = 0,73; p = 0,05) mostraram maior acurácia quando comparados à PVC (AUC = 0,69; p = 0,10), à PAPD (AUC = 0,61; p = 0,31) e à PAM (AUC = 0,67, p = 0,14) para predizer responsividade à expansão volêmica. Os melhores valores de corte para VPP (73.68% de sensibilidade e 88.89 de especificidade) e IDVCC (68.42% de sensibilidade e 88.89% de especificidade) foram de 6,41% e de 9,8%, respectivamente. Conclusões: A VPP e o IDVCC podem ser utilizados como índices dinâmicos de pré-carga para predizer a resposta à expansão volêmica no modelo experimental empregado. Palavras-chave: Índice de distensibilidade da veia cava caudal. Hemorragia. Hipovolemia. Ovelhas. Variação da pressão de pulso. Abstract: Objective: The objective of this study was to evaluate the distensibility index of the caudal vena cava (CVCDI) as an indicator of volume responsiveness in an experimental model of moderate hemorrhagic shock in sheep. Experimental design: Prospective experimental study. Animals: Seven adult sheep weighing 55.4 ± 9.56 kg (mean ± standard deviation). Methods: The animals were anesthetized with isoflurane and ventilated using the volume-controlled mode, with a tidal volume of 8 mL.kg -1 and neuromuscular blockade with atracurium. The cardiorespiratory and hemodynamic variables were evaluated before the hemorrhage (T0), immediately after the end of the exanguination (TChoque), after the mean arterial pressure (MAP) was maintained at 50 mmHg for 30 minutes (TChoque30), after each one of three fluid challenges with 10 mL.kg-1 of Ringer's lactate (TRes1, TRes2 and TRes3) and after autologous blood transfusion (TTrans). The correlation with changes in cardiac index (CI), area under the ROC (Receive Operating Characteristic) curve, sensitivity, specificity and cutoff values of PPV, CVCDI, central venous pressure (CVP), pulmonary artery diastolic pressure (PADP) and MAP were also determined. Results: The model induced the expected changes in hemodynamic variables and the volume resuscitation protocol was efficient in reversing these alterations. The PPV and CVCDI increased significantly in relation to the T0 moment after the hemorrhage and return to normal values after TRes1. The PPV (r = 0.70), CVCDI (r = 0.64) and MAP (r = 0.72) had a higher correlation with the CI than CVP (r = 0.48, p = 0.00041) and PADP (r =0.36, p = 0.0091). The PPV (AUC = 0.83, p = 0.005) and CVCDI (AUC = 0.73, p = 0.05) showed higher accuracy than VPC (AUC = 0.69, p = 0.10), PADP (AUC = 0.61, p = 0.31) and MAP (AUC = 0.67, p = 0.14) to predict responsiveness to the fluid challenge. The best cutoff values for PPV (73.68% sensitivity and 88.89 specificity) and CVCDI (68.42 sensitivity and 88.89% specificity) were 6.41% and 9.8%, respectively. Conclusions: PPV and CVCDI can be used as dynamic preload indexes to predict the response to volume expansion in the experimental model used. Key words: Distensibility index of the caudal vena cava. Haemorrhage. Hypovolemia. Sheep. Pulse pressure variation.

Published
2018

19. Efeito da ressuscitação volêmica com hidroxietilaminado 130/0,4 a 6% ou solução salina hipertônica 7,5% associados a solução de ringer com lactato ou solução salina a 0,9% em um modelo de choque hemorrágico controlado em ratos

Author

Moura, Rauane Sousa de, Universidade Federal do Paraná. Setor de Ciências Agrárias. Programa de Pós-Graduação em Ciências Veterinárias, and Duque Moreno, Juan Carlos

Subjects
Medicina Veterinária, Coloides
Abstract

Orientador: Prof. Dr. Juan Carlos Duque Moreno Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Agrárias, Programa de Pós-Graduação em Ciências Veterinárias. Defesa : Curitiba, 03/03/2017 Inclui referências Resumo: Este trabalho teve como objetivo determinar os efeitos da ressuscitação volêmica combinada, utilizando a solução salina hipertônica a 7,5% (SH) e hidroxietilamido 130/0,4 a 6% (HÁ), associados as soluções salina a 0,9% (NS) ou Ringer com lactato (RL). Foram utilizados 38 ratos Wistar, submetidos a choque hemorrágico experimental, divididos em 5 grupos: controle (GC, n = 6); salina hipertônica/salina 0,9% (GSH-NS, n = 8); salina hipertônica/Ringer com lactato (GSHRL, n = 8); coloide/salina 0,9% (GHA-NS n= 8); e coloide/Ringer com lactato (GHARL, n = 8). Com exceção do GC, todos os animais foram submetidos a choque hemorrágico controlado. Em seguida, tratados com solução SH ou solução HA, seguido de desafios hídricos com NS ou RL para manutenção da pressão arterial. Monitorou-se os parâmetros cardiorrespiratórios, gases sanguíneos e eletrólitos, e após eutanásia foi realizada avaliação histopatológica de rins, fígado, coração, pulmão, intestino e cérebro. Houve acidemia grave nos grupos GSH-NS e GHA-RL, hipercloremia somente no GSH-NS, e hiperlactatemia grave em GSH-RL e GHA-RL. A mortalidade foi de 37,5% em GSH-NS e GHA-NS, 25% em GSH-RL, e 50% em GHA-RL. Os grupos GHA-NS e GHA-RL apresentaram escores mais graves de lesão renal, e os grupos GSH-RL e GHA-RL apresentaram lesões hepáticas mais acentuadas. Concluiu-se que o uso das quatro associações promoveu melhora semelhante nos parâmetros cardiorrespiratórios, contudo o uso de hidroxietilamido 130/0,4 a 6% esteve associado a maior gravidade nas lesões renais, enquanto o RL induziu alterações mais graves no parênquima hepático. Abstract: The aim of study was to determine the effects of combined volume resuscitation, using 7.5% hypertonic saline solution (SH) and 6% hydroxyethyl starch 130/0.4 (HA), associated with 0.9% saline solutions ( NS) or lactated Ringer (RL). Thirty-eight Wistar rats, submitted to experimental hemorrhagic shock, were divided into 5 groups: control (CG, n = 6); hypertonic saline/0.9% saline (GSH-NS, n = 8); hypertonic saline/lactated Ringer (GSH-RL, n = 8); 0.9% colloid/saline (GHA-NS n=8); and lactated colloid/Ringer (GHA-RL, n = 8). With the exception of the CG, all animals underwent controlled hemorrhagic shock. Then treated with SH solution or HA solution, followed by water challenges with NS or RL to maintain blood pressure. Cardiorespiratory parameters, blood gases and electrolytes were monitored, and after euthanasia, histopathological evaluation of kidneys, liver, heart, lung, intestine and brain was performed. There was severe acidemia in the GSH-NS and GHA-RL groups, hyperchloremia only in the GSHNS, and severe hyperlactatemia in the GSH-RL and GHA-RL. Mortality was 37.5% in GSH-NS and GHA-NS, 25% in GSH-RL, and 50% in GHA-RL. The GHA-NS and GHARL groups had more severe kidney injury scores, and the GSH-RL and GHA-RL groups had more severe liver damage. It was concluded that the use of the four associations promoted a similar improvement in cardiorespiratory parameters, however the use of hydroxyethyl starch 130/0.4 at 6% was associated with greater severity in kidney injuries, while LR induced more severe changes in the liver parenchyma.

Published
2017

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