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1. High circulating CD4+CD25hiFOXP3+ T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome

Author

Durand, Maxim, Lacoste, Philippe, Danger, Richard, Jacquemont, Lola, Brosseau, Carole, Durand, Eugénie, Tilly, Gaelle, Loy, Jennifer, Foureau, Aurore, Royer, Pierre-Joseph, Tissot, Adrien, Roux, Antoine, Reynaud-Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Degauque, Nicolas, Magnan, Antoine, and Brouard, Sophie

Published
2018
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5. Leukocyte RhoA exchange factor Arhgefl mediates vascular inflammation and atherosclerosis

Author

Carbone, Maria Luigia, Chadeuf, Gilliane, Heurtebise-Chretien, Sandrine, Prieur, Xavier, Quillard, Thibault, Goueffic, Yann, Rio, Marc, Vaillant, Nathalie, Castan, Laure, Durand, Maxim, Baron-Menguy, Celine, Aureille, Julien, Desfrancois, Juliette, Tesse, Angela, Torres, Raul M., and Loirand, Gervaise

Subjects
Analysis, Development and progression, Risk factors, Health aspects, White blood cells -- Health aspects, Low density lipoproteins -- Analysis, Atherosclerosis -- Development and progression, Hypertension -- Development and progression, Heart attack -- Development and progression, Inflammation -- Risk factors
Abstract

Introduction Angiotensin II (Ang II) is considered as the main mediator of both the physiological and the pathophysiological actions of the renin-angiotensin-aldosterone system (RAAS) through the stimulation of the Ang [...], Abnormal activity of the renin-angiotensin-aldosterone system plays a causal role in the development of hypertension, atherosclerosis, and associated cardiovascular events such as myocardial infarction, stroke, and heart failure. As both a vasoconstrictor and a proinflammatory mediator, angiotensin II (Ang II) is considered a potential link between hypertension and atherosclerosis. However, a role for Ang II-induced inflammation in atherosclerosis has not been clearly established, and the molecular mechanisms and intracellular signaling pathways involved are not known. Here, we demonstrated that the RhoA GEF Arhgefl is essential for Ang II-induced inflammation. Specifically, we showed that deletion of Arhgef1 in a murine model prevents Ang II-induced integrin activation in leukocytes, thereby preventing Ang II-induced recruitment of leukocytes to the endothelium. Mice lacking both LDL receptor (LDLR) and Arhgef1 were protected from high-fat diet-induced atherosclerosis. Moreover, reconstitution of [Ldlr.sup.-/-] mice with Arhgef1-deficient BM prevented high-fat diet-induced atherosclerosis, while reconstitution of [Ldlr.sup.-/-] [Arhgefl.sup.-/-] with WT BM exacerbated atherosclerotic lesion formation, supporting Arhgef1 activation in leukocytes as causal in the development of atherosclerosis. Thus, our data highlight the importance of Arhgef1 in cardiovascular disease and suggest targeting Arhgef1 as a potential therapeutic strategy against atherosclerosis.

Published
2017
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7. Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Author

Brosseau, Carole, Danger, Richard, Durand, Maxim, Durand, Eugénie, Foureau, Aurore, Lacoste, Philippe, Tissot, Adrien, Roux, Antoine, Reynaud-Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Magnan, Antoine, Brouard, Sophie, COLT and SysCLAD Consortia, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vaincre La Mucoviscidose, ANR-17-CE17-0008,Biket,Cellules B GZMB+, un facteur clé de l'immunité chez l'homme?(2017), and Gasche-Soccal, Paola Marina Alessandra

Subjects
medicine.medical_specialty, medicine.medical_treatment, Basic (laboratory) research/science, basic (laboratory) research, Bronchiolitis obliterans, Bronchiolitis obliterans (BOS), B cell biology, 030230 surgery, Peripheral blood mononuclear cell, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, lung transplantation, medicine, Immunology and Allergy, Lung transplantation, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Pharmacology (medical), pulmonology, science, B cell, ddc:616, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Transplantation, Lung, business.industry, Incidence (epidemiology), Biomarker, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, medicine.anatomical_structure, translational research, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, biomarker, Biomarker (medicine), Translational research/science, Lung transplantation/pulmonology, bronchiolitis obliterans (BOS), business
Abstract

International audience; Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24(hi)CD38(hi) transitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24(hi)CD38(hi) transitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9(+) B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24(hi)CD38(hi) transitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome-free survival.

Published
2019
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9. CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients

Author

Bousseau, Carole, Durand, Maxim, Colas, Luc, Durand, Eugenie, Foureau, Aurore, Cheminant, Marie-Aude, Bouchaud, Grégory, Castan, Laure, Klein, Martin, Magnan, Antoine, Brouard, Sophie, Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Immunoregulation And Immunointervention in Transplantation and Autoimmunity (Team 4 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), INRA Centre Angers-Nantes [Nantes, France], CIC biothérapies CBT 0503 [Nantes], Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), This work was supported by a grant from l’Institut de Recherche en Santé Respiratoire-Pays de la Loire. This work was achieved in the context of the BASAL project financed by Région Pays de la Loire and the IHU-Cesti project, the DHU Oncogreffe and the LabEX IGO thanks to French government financial support managed by the National Research Agency via the Investment into the Future program (ANR-10-IBHU-005 and ANR-11-LABX-0016-01). The IHU-Cesti project is also supported by Nantes Métropole and Région Pays de la Loire., ANR-10-IBHU-0005,CESTI (TSI-IHU),Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU)(2010), ANR-11-LABX-0016,IGO,Immunothérapies Grand Ouest(2011), Le Bihan, Sylvie, Instituts Hospitalo-Universitaires B - Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU) - - CESTI (TSI-IHU)2010 - ANR-10-IBHU-0005 - IBHU - VALID, Laboratoires d'excellence - Immunothérapies Grand Ouest - - IGO2011 - ANR-11-LABX-0016 - LABX - VALID, Unité de recherche de l'institut du thorax (ITX-lab), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), and Institut National de la Recherche Agronomique (INRA)

Subjects
Adult, Male, severe asthma, [SDV.IMM] Life Sciences [q-bio]/Immunology, MAP Kinase Signaling System, Immunology, Cell Communication, Mitochondrial Dynamics, Severity of Illness Index, Tetraspanin 29, Mice, effector T cells, T-Lymphocyte Subsets, regulatory B cells, CD9(+) B cells, apoptosis, Animals, Humans, Prospective Studies, Lung, Original Research, Aged, B-Lymphocytes, Regulatory, CD9+ B cells, Middle Aged, G1 Phase Cell Cycle Checkpoints, Asthma, Interleukin-10, Disease Models, Animal, embryonic structures, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, CD9 + B cells
Abstract

International audience; CD9 was recently identified as a marker of murine IL-10-competent regulatory B cells. Functional impairments or defects in CD9 + IL-10-secreting regulatory B cells are associated with enhanced asthma-like inflammation and airway hyperresponsiveness. In mouse models, all asthma-related features can be abrogated by CD9 + B cell adoptive transfer. We aimed herein to decipher the profiles, features, and molecular mechanisms of the regulatory properties of CD9 + B cells in human and mouse. The profile of CD9 + B cells was analyzed using blood from severe asthmatic patients and normal and asthmatic mice by flow cytometry. The regulatory effects of mouse CD9 + B cells on effector T cell death, cell cycle arrest, apoptosis, and mitochondrial depolarization were determined using yellow dye, propidium iodide, Annexin V, and JC-1 staining. MAPK phosphorylation was analyzed by western blotting. Patients with severe asthma and asthmatic mice both harbored less CD19 + CD9 + B cells, although these cells displayed no defect in their capacity to induce T cell apoptosis. Molecular mechanisms of regulation of CD9 + B cells characterized in mouse showed that they induced effector T cell cycle arrest in sub G0/G1, leading to apoptosis in an IL-10-dependent manner. This process occurred through MAPK phosphorylation and activation of both the intrinsic and extrinsic pathways. This study characterizes the molecular mechanisms underlying the regulation of CD9 + B cells to induce effector T cell apoptosis in mice and humans via IL-10 secretion. Defects in CD9 + B cells in blood from patients with severe asthma reveal new insights into the lack of regulation of inflammation in these patients.

Published
2018
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10. High circulating CD4+CD25[hi]FOXP3+ T cell subpopulation early after lung transplantation is associated with development of BOS

Author

Durand, Maxim, Lacoste, Philippe, Danger, Richard, Jacquemont, Lola, Brosseau, Carole, Durand, Eugénie, Tilly, Gaëlle, Loy, Jennifer, Foureau, Aurore, Royer, Pierre-Joseph, Tissot, Adrien, Magnan, Antoine, Brouard, Sophie, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Faculté de Médecine - Université de Nantes, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), CIC biothérapies CBT 0503 [Nantes], Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), COLT and SysCLAD Consortia, and Le Bihan, Sylvie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

11. GZMB+ B cells, a key factor of cell immunity in human?

Author

Chesneau, Mélanie, Le Bot, Sabine, Poulaouec, Cyrielle, Danger, Richard, Dubois, Florian, Durand, Maxim, Jacquemont, Lola, Guerrif, Pierrick, Degauque, Nicolas, Giral, Magali, Brouard, Sophie, Le Bihan, Sylvie, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), CIC biothérapies CBT 0503 [Nantes], and Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

14. High circulating CD4 + CD25 hi FOXP3 + T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome

Author

Durand, Maxim, primary, Lacoste, Philippe, additional, Danger, Richard, additional, Jacquemont, Lola, additional, Brosseau, Carole, additional, Durand, Eugénie, additional, Tilly, Gaelle, additional, Loy, Jennifer, additional, Foureau, Aurore, additional, Royer, Pierre-Joseph, additional, Tissot, Adrien, additional, Roux, Antoine, additional, Reynaud-Gaubert, Martine, additional, Kessler, Romain, additional, Mussot, Sacha, additional, Dromer, Claire, additional, Brugière, Olivier, additional, Mornex, Jean François, additional, Guillemain, Romain, additional, Claustre, Johanna, additional, Degauque, Nicolas, additional, Magnan, Antoine, additional, and Brouard, Sophie, additional

Published
2018
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15. COLT: 10 ans de recherche en transplantation pulmonaire, résultats et perspectives

Author

Tissot, Adrien, Foureau, Aurore, Brosseau, Carole, Danger, Richard, Roux, Antoine, Bernasconi, Eric, Gomez, Carine, Durand, Maxim, Picard, B.R., Le Pavec, Jérôme, Claustre, Johanna, Lacoste, Philippe, Benmerad, Meriem, Pain, Mallory, Siroux, Valérie, Royer, Pierre Joseph, Mordant, Pierre, Reynaud-Gaubert, Martine, Kessler, Romain, Brugiere, Olivier, Mornex, Jean-François, Dromer, Claire, Dahan, Marcel, Knoop, Christiane, Boussaud, Véronique, Koutsokera, Angela, Botturi-Cavaillès, K., Durand, Eugénie, Loy, Jennifer, Nicod, Laurent Pierre, Pison, Christophe, Brouard, Sophie, Blanc, François Xavier, Magnan, Antoine, Tissot, Adrien, Foureau, Aurore, Brosseau, Carole, Danger, Richard, Roux, Antoine, Bernasconi, Eric, Gomez, Carine, Durand, Maxim, Picard, B.R., Le Pavec, Jérôme, Claustre, Johanna, Lacoste, Philippe, Benmerad, Meriem, Pain, Mallory, Siroux, Valérie, Royer, Pierre Joseph, Mordant, Pierre, Reynaud-Gaubert, Martine, Kessler, Romain, Brugiere, Olivier, Mornex, Jean-François, Dromer, Claire, Dahan, Marcel, Knoop, Christiane, Boussaud, Véronique, Koutsokera, Angela, Botturi-Cavaillès, K., Durand, Eugénie, Loy, Jennifer, Nicod, Laurent Pierre, Pison, Christophe, Brouard, Sophie, Blanc, François Xavier, and Magnan, Antoine

Abstract

SCOPUS: ed.j, info:eu-repo/semantics/published

Published
2018

16. High Circulating CD4 + CD25 hi FOXP3 + T Cell Subpopulation Early After Lung Transplantation is Associated With Development of Bronchiolitis Obliterans Syndrome

Author

Nicolas Degauque, Philippe Lacoste, Sophie Brouard, Lola Jacquemont, Antoine Magnan, Richard Danger, Carole Brosseau, and Durand Maxim

Subjects
Pulmonary and Respiratory Medicine, Transplantation, business.industry, medicine.medical_treatment, T cell, Bronchiolitis obliterans, medicine.disease, medicine.anatomical_structure, Immunology, medicine, Lung transplantation, Surgery, business, Cardiology and Cardiovascular Medicine
Published
2018
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17. Blood CD9+B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Author

Brosseau, Carole, Danger, Richard, Durand, Maxim, Durand, Eugénie, Foureau, Aurore, Lacoste, Philippe, Tissot, Adrien, Roux, Antoine, Reynaud-Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Magnan, Antoine, and Brouard, Sophie

Abstract

Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24hiCD38hitransitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hiCD38hitransitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9+B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24hiCD38hitransitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.

Published
2019
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19. Expression of miR-142-5p in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Chronic Antibody-Mediated Rejection

Author

Danger, Richard, primary, Paul, Chloé, additional, Giral, Magali, additional, Lavault, Amélie, additional, Foucher, Yohann, additional, Degauque, Nicolas, additional, Pallier, Annaïck, additional, Durand, Maxim, additional, Castagnet, Stéphanie, additional, Duong Van Huyen, Jean-Paul, additional, Delahousse, Michel, additional, Renaudin, Karine, additional, Soulillou, Jean-Paul, additional, and Brouard, Sophie, additional

Published
2013
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20. CD9 + Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients.

Author

Brosseau C, Durand M, Colas L, Durand E, Foureau A, Cheminant MA, Bouchaud G, Castan L, Klein M, Magnan A, and Brouard S

Subjects
Adult, Aged, Animals, Apoptosis immunology, Asthma blood, Asthma diagnosis, B-Lymphocytes, Regulatory metabolism, Cell Communication immunology, Disease Models, Animal, Female, G1 Phase Cell Cycle Checkpoints immunology, Humans, Interleukin-10 immunology, Lung, MAP Kinase Signaling System immunology, Male, Mice, Middle Aged, Mitochondrial Dynamics immunology, Prospective Studies, Severity of Illness Index, T-Lymphocyte Subsets cytology, T-Lymphocyte Subsets metabolism, Tetraspanin 29 metabolism, Asthma immunology, B-Lymphocytes, Regulatory immunology, Interleukin-10 metabolism, T-Lymphocyte Subsets immunology
Abstract

CD9 was recently identified as a marker of murine IL-10-competent regulatory B cells. Functional impairments or defects in CD9 + IL-10-secreting regulatory B cells are associated with enhanced asthma-like inflammation and airway hyperresponsiveness. In mouse models, all asthma-related features can be abrogated by CD9 + B cell adoptive transfer. We aimed herein to decipher the profiles, features, and molecular mechanisms of the regulatory properties of CD9 + B cells in human and mouse. The profile of CD9 + B cells was analyzed using blood from severe asthmatic patients and normal and asthmatic mice by flow cytometry. The regulatory effects of mouse CD9 + B cells on effector T cell death, cell cycle arrest, apoptosis, and mitochondrial depolarization were determined using yellow dye, propidium iodide, Annexin V, and JC-1 staining. MAPK phosphorylation was analyzed by western blotting. Patients with severe asthma and asthmatic mice both harbored less CD19 + CD9 + B cells, although these cells displayed no defect in their capacity to induce T cell apoptosis. Molecular mechanisms of regulation of CD9 + B cells characterized in mouse showed that they induced effector T cell cycle arrest in sub G0/G1, leading to apoptosis in an IL-10-dependent manner. This process occurred through MAPK phosphorylation and activation of both the intrinsic and extrinsic pathways. This study characterizes the molecular mechanisms underlying the regulation of CD9 + B cells to induce effector T cell apoptosis in mice and humans via IL-10 secretion. Defects in CD9 + B cells in blood from patients with severe asthma reveal new insights into the lack of regulation of inflammation in these patients.

Published
2018
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