118 results on '"Dusina, Alex"'
Search Results
2. A 67-Year-Old Man with Chronic Lymphocytic Leukemia (CLL) on Maintenance Therapy with Ibrutinib with Persistent SARS-CoV-2 Infection Unresponsive to Antiviral Treatments
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Sanmartin, Flavia, primary, Magrini, Eugenia, additional, Rando, Emanuele, additional, Del Giacomo, Paola, additional, Dusina, Alex, additional, Matteini, Elena, additional, Carbone, Andrea, additional, Puma, Giuseppe, additional, Leanza, Gabriele Maria, additional, Frondizi, Federico, additional, Innocenti, Idanna, additional, Maiuro, Giuseppe, additional, Liotti, Flora Marzia, additional, Santangelo, Rosaria, additional, Laurenti, Luca, additional, and Cingolani, Antonella, additional
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- 2024
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3. Difference in the neurocognitive functions of WLWH and MLWH in an Italian cohort of people living with HIV
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Donne, Valentina Delle, Massaroni, Valentina, Ciccarelli, Nicoletta, Lombardi, Francesca, Borghetti, Alberto, Ciccullo, Arturo, Dusina, Alex, Farinacci, Damiano, Baldin, Ganmaria, Visconti, Elena, Tamburrini, Enrica, and Di Giambenedetto, Simona
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- 2022
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4. Efficacy of Lamivudine plus Dolutegravir versus Dolutegravir-based Three-drugs Regimens in Virologically-suppressed People Living with HIV
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Borghetti, Alberto, primary, Ciccullo, Arturo, additional, Lombardi, Francesca, additional, Giannarelli, Diana, additional, Passerotto, Rosa Anna, additional, Lamanna, Francesco, additional, Carcagnì, Antonella, additional, Farinacci, Damiano, additional, Dusina, Alex, additional, Baldin, Gianmaria, additional, Zazzi, Maurizio, additional, and Di Giambenedetto, Simona, additional
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- 2024
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5. Cerebrospinal fluid drain infection caused by pandrug-resistant Staphylococcus epidermidis successfully treated with ceftaroline in combination with fosfomycin and vancomycin
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MAGRINI, Eugenia, primary, RANDO, Emanuele, additional, GIACOMO, Paola DEL, additional, MATTEINI, Elena, additional, LEANZA, Gabriele Maria, additional, SANMARTIN, Flavia, additional, CARBONE, Andrea, additional, MAIURO, Giuseppe, additional, DUSINA, Alex, additional, and CINGOLANI, Antonella, additional
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- 2024
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6. The association between stigma and wellbeing in an Italian cohort of PLWH: The role of social support and personal factors
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Delle Donne, Valentina, Massaroni, Valentina, Lombardi, Francesca, Dusina, Alex, Salvo, Pierluigi Francesco, Borghetti, Alberto, Ciccullo, Arturo, Visconti, Elena, Di Giambenedetto, Simona, Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Delle Donne, Valentina, Massaroni, Valentina, Lombardi, Francesca, Dusina, Alex, Salvo, Pierluigi Francesco, Borghetti, Alberto, Ciccullo, Arturo, Visconti, Elena, Di Giambenedetto, Simona, and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Our aim was to assess the association between different types of stigma and physical, behavioural and emotional wellbeing, and to evaluate whether these associations were mediated by the level of social support, age, education, sex and time from HIV diagnosis in an Italian cohort of people living with HIV (PLWH). We enrolled 96 PLWH and had them complete a cross-sectional online survey that included the "HSS-12", the "SF-12" and the "DASS-21". We performed linear regression analyses to explore the associations between the HSS-12 scores and cART adherence, viral load, SF-12 and DASS-21 scores, and a mediation analysis to identify mediators in the significant associations. We showed that higher level of depression and worse perception of mental health were significantly associated with higher HSS-12 "personalised stigma" (p = .009, p = .020) "disclosure concerns" (p = .012, p = .039), "concerns about public attitudes" (p =.007, p = .005) and "negative self-image" scores; (p < .001, p = .001); worse perception of physical health status was associated with higher HSS-12 "personalised stigma" scores (p = .018); higher level of anxiety and stress were associated with higher "negative self-image" scores (0.001 and p < .001). The association between higher HSS-12 "negative self-image" and higher levels of depression, anxiety and stress were mediated by lower age (a*b = +0.10; a*b = +0.12; a*b = +0.11). This study may have important implications for clinical practice as it contributes to understanding the characteristics and consequences of HIV-related stigma in a population of PLWH with excellent viroimmunological status and therapeutic adherence.
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- 2024
7. Efficacy of Lamivudine Plus Dolutegravir vs Dolutegravir-Based 3-Drug Regimens in People With HIV Who Are Virologically Suppressed
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Borghetti, Alberto, Ciccullo, Arturo, Lombardi, Francesca, Giannarelli, Diana, Passerotto, Rosa Anna, Lamanna, Francesco, Carcagnì, Antonella, Farinacci, Damiano, Dusina, Alex, Baldin, Gianmaria, Zazzi, Maurizio, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Borghetti, Alberto, Ciccullo, Arturo, Lombardi, Francesca, Giannarelli, Diana, Passerotto, Rosa Anna, Lamanna, Francesco, Carcagnì, Antonella, Farinacci, Damiano, Dusina, Alex, Baldin, Gianmaria, Zazzi, Maurizio, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Background: Lamivudine + dolutegravir maintenance dual therapy (DT) could be less effective than 3-drug therapy (TT) in the context of resistance-associated mutations to nucleoside reverse transcriptase inhibitors (NRTIs). The ARCA database was queried to test this hypothesis with a trial emulation strategy. Methods: People with HIV taking 2 NRTIs plus a protease inhibitor or a non-NRTI who switched to DT or dolutegravir-based TT were followed up from the first HIV RNA <50 copies/mL (baseline) to virologic failure (VF; ie, 2 consecutive HIV RNA ≥50 copies/mL or 1 HIV RNA ≥200 copies/mL). Those switching to DT within 6 months were assigned to the treatment arm and all other patients to the control arm. Each participant was also cloned, assigned to the opposite strategy, and censored at the time of deviation from that strategy. Using inverse probability of censoring weight Cox regression models, we calculated hazard ratios of VF for DT vs TT stratified for the presence of resistance-associated mutations. Results: Overall 626 people were analyzed: 204 with DT and 422 with TT (73% men; mean age, 44 years). Ten and 31 VFs occurred with DT and TT, respectively, over a median 5.8 years. When compared with a fully active TT, the DT had similar efficacy (adjusted hazard ratio, 0.88; 95% CI, .29-2.61; P = .812) when full susceptibility was confirmed at historical genotype. When previous M184V/I was present in both groups, the risk of VF was higher for DT vs TT but was not statistically significant (adjusted hazard ratio, 3.06; 95% CI, .45-20.84; P = .252). Conclusions: DT was not associated with a significantly higher risk of VF than dolutegravir-based TT.
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- 2024
8. The association between stigma and wellbeing in an Italian cohort of PLWH: The role of social support and personal factors
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Delle Donne, Valentina, primary, Massaroni, Valentina, additional, Lombardi, Francesca, additional, Dusina, Alex, additional, Salvo, Pierluigi Francesco, additional, Borghetti, Alberto, additional, Ciccullo, Arturo, additional, Visconti, Elena, additional, and Di Giambenedetto, Simona, additional
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- 2023
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9. The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition
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Delle Donne, Valentina, Ciccarelli, Nicoletta, Massaroni, Valentina, Borghetti, Alberto, Dusina, Alex, Farinacci, Damiano, Visconti, Elena, Tamburrini, Enrica, Fabbiani, Massimiliano, and Di Giambenedetto, Simona
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- 2020
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10. Characteristics of mental health interventions in a cohort of Italian PLWH over the last five years: impact of HIV disease and outbreak of COVID-19 pandemic
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Delle Donne, Valentina, primary, Massaroni, Valentina, additional, Borghetti, Alberto, additional, Ciccullo, Arturo, additional, Dusina, Alex, additional, Lombardi, Francesca, additional, Steiner, Rebecca Jo, additional, Iannone, Valentina, additional, Salvo, Pierluigi Francesco, additional, and Di Giambenedetto, Simona, additional
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- 2023
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11. Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
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Passerotto, Rosa Anna, primary, Lamanna, Francesco, additional, Farinacci, Damiano, additional, Dusina, Alex, additional, Di Giambenedetto, Simona, additional, Ciccullo, Arturo, additional, and Borghetti, Alberto, additional
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- 2023
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12. SARS-CoV-2 infection in a highly experienced person living with HIV
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Di Giambenedetto, Simona, Del Giacomo, Paola, Ciccullo, Arturo, Porfidia, Angelo, De Matteis, Giuseppe, Cianci, Rossella, De Vito, Francesco, Dusina, Alex, Borghetti, Alberto, and Tumbarello, Mario
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- 2020
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13. No significant changes in body fat mass in virologically suppressed, HIV-positive patients switched to lamivudine--dolutegravir
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Ciccullo, Arturo, Dusina, Alex, Lassandro, Anna Pia, Borghetti, Alberto, Baldin, Gianmaria, and Di Giambenedetto, Simona
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- 2020
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14. Changes in Metabolic Profile in PLWHIV Switching to Doravirine-Based Regimen
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Iannone, Valentina, primary, Passerotto, Rosa Anna, additional, Lamanna, Francesco, additional, Steiner, Rebecca Jo, additional, Lombardi, Francesca, additional, Salvo, Pierluigi Francesco, additional, Dusina, Alex, additional, Farinacci, Damiano, additional, Borghetti, Alberto, additional, Di Giambenedetto, Simona, additional, and Ciccullo, Arturo, additional
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- 2023
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15. Characteristics of mental health interventions in a cohort of Italian PLWH over the last five years: impact of HIV disease and outbreak of COVID-19 pandemic
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Delle Donne, Valentina, Massaroni, Valentina, Borghetti, Alberto, Ciccullo, Arturo, Dusina, Alex, Lombardi, Francesca, Steiner, Rebecca Jo, Iannone, Valentina, Salvo, Pierluigi Francesco, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Delle Donne, Valentina, Massaroni, Valentina, Borghetti, Alberto, Ciccullo, Arturo, Dusina, Alex, Lombardi, Francesca, Steiner, Rebecca Jo, Iannone, Valentina, Salvo, Pierluigi Francesco, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Evidence accumulated during past years confirm that people living with HIV (PLWH) still have to deal with comorbidities and chronic complications that can increase physical and psychological issues and can affect daily functioning, quality of life and mental health. Moreover, during the COVID-19 pandemic PLWH proved to be a population at increased risk of psychological distress. We explored the ongoing issues and the characteristics of the mental health interventions for which a cohort of Italian PLWH interacted with a psychologist over the past five years. We analysed a dataset that included 61 PLWH who underwent a psychological intervention between 2018 and 2022. We compared different frequencies in characteristics of mental health interventions according to different demographic and clinical variables, psychopathological symptoms and time of the request for intervention. We showed that psychopathological symptoms most frequently reported by patients were anxiety (55.7%), and depression (49.2%). Furthermore, we reported that most our patients undertook occasional psychological support meetings (31%), sought an intervention after the outbreak of the COVID-19 pandemic (62.3%) and complained about disclosure issues (48.5%). Disclosure issues were mainly reported by younger PLWH (p = 0.002) with a shorter disease (p = 0.031) and treatment history (p = 0.032), and higher interpersonal sensitivity (p = 0.042). It seems fundamental to integrate psychological interventions into the care of PLWH, to give particular attention to PLWH with risky demographic, clinical and mental health factors and to pay special attention to emergency conditions (such as the COVID-19 pandemic) and the most widespread issues to create ad hoc interventions.
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- 2023
16. Changes in Metabolic Profile in PLWHIV Switching to Doravirine-Based Regimen
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Iannone, Valentina, Passerotto, Rosa Anna, Lamanna, Francesco, Steiner, Rebecca Jo, Lombardi, Francesca, Salvo, Pierluigi Francesco, Dusina, Alex, Farinacci, Damiano, Borghetti, Alberto, Di Giambenedetto, Simona, Ciccullo, Arturo, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Iannone, Valentina, Passerotto, Rosa Anna, Lamanna, Francesco, Steiner, Rebecca Jo, Lombardi, Francesca, Salvo, Pierluigi Francesco, Dusina, Alex, Farinacci, Damiano, Borghetti, Alberto, Di Giambenedetto, Simona, Ciccullo, Arturo, Lombardi, Francesca (ORCID:0000-0001-5757-8346), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Thanks to the modern ARV regimens and the fact that the morbidity and mortality of metabolic syndrome increases with age, clinicians are continuously researching effective and safe antiretroviral regimens with low impact on the lipid profile. Doravirine (DOR) is the latest non-nucleoside reverse-transcriptase inhibitor (NNRTI) that shows long-term safety and tolerability and a favorable lipid profile. The aim of this study is to assess the impact of DOR-based three-drug regimens on the lipid profile in clinical practice. We retrospectively analyzed a cohort of 38 treatment-experienced, virologically suppressed people living with HIV (PLWH) switching to this regimen, following the eligibility criteria. We carried out comparison analysis of immunological and metabolic parameters between baseline and 48 weeks of follow up. In our cohort of treatment-experienced, virologically suppressed PLWH, three-drug regimens with DOR showed good efficacy and a positive profile on lipid metabolism at 48 weeks of follow up.
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- 2023
17. Cerebrospinal Fluid Drain Infection Caused by Pandrug-Resistant Staphylococcus Epidermidis Successfully Treated with Ceftaroline in Combination with Fosfomycin and Vancomycin
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Magrini, Eugenia, primary, Rando, Emanuele, additional, Del Giacomo, Paola, additional, Matteini, Elena, additional, Leanza, Gabriele Maria, additional, Sanmartin, Flavia, additional, Carbone, Andrea, additional, Maiuro, Giuseppe, additional, Dusina, Alex, additional, and Cingolani, Antonella, additional
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- 2023
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18. Cardiovascular Disease Risk in a Cohort of Virologically Suppressed People Living with HIV Switching to Doravirine: Preliminary Data from the Real Life
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Iannone, Valentina, primary, Farinacci, Damiano, additional, D'Angelillo, Anna, additional, Dusina, Alex, additional, Lamanna, Francesco, additional, Passerotto, Rosanna, additional, Baldin, Gianmaria, additional, Visconti, Elena, additional, Tamburrini, Enrica, additional, Borghetti, Alberto, additional, Di Giambenedetto, Simona, additional, and Ciccullo, Arturo, additional
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- 2022
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19. Home Care Assistance: Has Covid-19 had an Impact on the Complex Management of HIV Patients?
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Dusina, Alex, primary, Lombardi, Francesca, additional, Tamburrini, Enrica, additional, Onorati, Fiorella, additional, Petrucci, Massimo, additional, and Di Giambenedetto, Simona, additional
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- 2022
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20. Are we ready for long‐acting? A feasibility evaluation of long‐acting cabotegravir–rilpivirine in clinical practice
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Borghetti, Alberto, primary, Farinacci, Damiano, additional, Ciccullo, Arturo, additional, Dusina, Alex, additional, Moschese, Davide, additional, Iannone, Valentina, additional, D'Angelillo, Anna, additional, Lombardi, Francesca, additional, Donne, Valentina Delle, additional, Massaroni, Valentina, additional, Visconti, Elena, additional, Tamburrini, Enrica, additional, and Di Giambenedetto, Simona, additional
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- 2022
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21. Difference in the neurocognitive functions of WLWH and MLWH in an Italian cohort of people living with HIV
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Delle Donne, Valentina, Massaroni, Valentina, Ciccarelli, Nicoletta, Lombardi, Francesca, Borghetti, Alberto, Ciccullo, Arturo, Dusina, Alex, Farinacci, Damiano, Baldin, Ganmaria, Visconti, Elena, Tamburrini, Enrica, Di Giambenedetto, Simona, Donne, Valentina Delle, Ciccarelli, Nicoletta (ORCID:0000-0002-7582-9142), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Delle Donne, Valentina, Massaroni, Valentina, Ciccarelli, Nicoletta, Lombardi, Francesca, Borghetti, Alberto, Ciccullo, Arturo, Dusina, Alex, Farinacci, Damiano, Baldin, Ganmaria, Visconti, Elena, Tamburrini, Enrica, Di Giambenedetto, Simona, Donne, Valentina Delle, Ciccarelli, Nicoletta (ORCID:0000-0002-7582-9142), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Based on the available literature, women living with HIV (WLWH) seem to show greater cognitive and emotional disadvantages than men living with HIV (MLWH). Our aim was to compare the cognitive performance of MLWH and WLWH in an Italian cohort of People Living With HIV (PLWH) and to analyse factors potentially contributing to sex differences in cognitive function. We ran a retrospective, cross-sectional analysis of a monocentric dataset of PLWH who were administered a standardized neuropsychological test battery (SNB) during routine clinical care. We enrolled 161 Italian PLWH who are on combined antiretroviral therapy (cART): 114 (70.8%) MLWH and 47 (29.2%) WLWH. Global cognitive performance (composite z score) (GCP) was significantly higher in MLWH than WLWH [mean 0.19 (SD 0.85) vs − 0.13 (SD 0.96); p = 0.039]. Moreover, WLWH obtained significantly higher scores on the Zung Depression Scale than MLWH [mean 41.8 (SD 10.9) vs 36.7 (SD 9.2); p = 0.003]. However, there was no statistically significant direct effect between male sex and better GCP (p = 0.692) in the context of a mediation model. On the contrary, the associations between male sex and better GCP were mediated by higher level of education (a*b = + 0.15, Bootstrap CI95 = 0.05 and 0.27) and a lower Zung depression score (a*b = + 0.10, Bootstrap CI95 = 0.02 and 0.21). In conclusion, the global cognitive performance of WLWH is lower than that of MLWH. However, other demographic and clinical factors besides sex might help explain differences in their neurocognitive functions and make it possible for us to monitor them and identify those patients most in need.
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- 2022
22. Are we ready for long-acting? A feasibility evaluation of long-acting cabotegravir–rilpivirine in clinical practice
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Borghetti, Alberto, Farinacci, Damiano, Ciccullo, A., Dusina, Alex, Moschese, D., Iannone, Valentina, D'Angelillo, Anna, Lombardi, Francesca, Donne, V. D., Massaroni, V., Visconti, Elena, Tamburrini, Enrica, Di Giambenedetto, Simona, Borghetti A., Farinacci D., Dusina A., Iannone V., D'Angelillo A., Lombardi F. (ORCID:0000-0001-5757-8346), Visconti E., Tamburrini E. (ORCID:0000-0003-4930-426X), Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Borghetti, Alberto, Farinacci, Damiano, Ciccullo, A., Dusina, Alex, Moschese, D., Iannone, Valentina, D'Angelillo, Anna, Lombardi, Francesca, Donne, V. D., Massaroni, V., Visconti, Elena, Tamburrini, Enrica, Di Giambenedetto, Simona, Borghetti A., Farinacci D., Dusina A., Iannone V., D'Angelillo A., Lombardi F. (ORCID:0000-0001-5757-8346), Visconti E., Tamburrini E. (ORCID:0000-0003-4930-426X), and Di Giambenedetto S. (ORCID:0000-0001-6990-5076)
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Cabotegravir and rilpivirine are the first drugs to be approved as injectable therapy to treat individuals with HIV. Despite encouraging results, the guidelines specify strict criteria for eligibility that could limit the feasibility of this strategy. We collected the clinical data of HIV-positive patients who were being treated at a single, third-level center in Italy. All patients were on stable therapy and showed suppressed viral load on their most recent analyses. We performed a cross-sectional analysis of the clinical and viro-immunological characteristics of this population and excluded patients who had previous virological failures, resistance-associated mutations (RAMs) to rilpivirine or integrase inhibitors in the historical genotype, hepatitis B infection, absence of previous genotypes, and the coexistence of HIV-subtype A and obesity. Our aim was to evaluate the proportion of patients who could be eligible for switching to this strategy. one thousand seven hundred fifty-two patients were eligible. One hundred and forty-eight were excluded because of a detectable viral load. With regard to the exclusion criteria, 48 patients had coinfection with hepatitis B virus, and 744 had a history of previous virological failures. Of the 896 patients with at least one genotypic resistance test, 161 had one or more RAMs to rilpivirine and 3 had RAMs to cabotegravir. None of the patients presented the combination of obesity and the A viral subtype. Overall, 31.2% of the patients were ineligible for cabotegravir–rilpivirine, and the proportion increased to 47.3% when we considered only patients with all available information concerning resistance tests. Approximately half of our cohort of patients did not fulfill the criteria and even more patients were potentially ineligible for cabotegravir–rilpivirine due to the lack of genotypic resistance tests. Also, fertile women had to be excluded due to the lack of data about this combination during pregnancy
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- 2022
23. Cardiovascular Disease Risk in a Cohort of Virologically Suppressed People Living with HIV Switching to Doravirine: Preliminary Data from the Real Life
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Iannone, Valentina, Farinacci, Damiano, D'Angelillo, Anna, Dusina, Alex, Lamanna, Francesco, Passerotto, Rosanna, Baldin, Gianmaria, Visconti, Elena, Tamburrini, Enrica, Borghetti, Alberto, Di Giambenedetto, Simona, Ciccullo, Arturo, Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Iannone, Valentina, Farinacci, Damiano, D'Angelillo, Anna, Dusina, Alex, Lamanna, Francesco, Passerotto, Rosanna, Baldin, Gianmaria, Visconti, Elena, Tamburrini, Enrica, Borghetti, Alberto, Di Giambenedetto, Simona, Ciccullo, Arturo, Tamburrini, Enrica (ORCID:0000-0003-4930-426X), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Aim of this study is to assess the impact of doravirine (DOR)-based regimens on cardiovascular risk in treatment-experienced people living with HIV (PLWHIV). We retrospectively analyzed a cohort of 40 treatment-experienced PLWHIV switching to a DOR-based three-drug regimen, evaluating 10-year risk of manifesting clinical cardiovascular diseases (CD) through the Framingham Risk Score at baseline, 12, and 24 weeks of follow-up. At baseline, median predicted 10-year risk of cardiovascular disease (10Y-CD) was 8.0% (interquartile range 4.0-13.0). After 12 weeks, we observed a significant reduction in 10Y-CD (mean decrease -2.21, p = .012); similarly, we observed a nonsignificant reduction at week 24 (p = .336). Regarding metabolic parameters, after 24 weeks we observed a significant reduction in total cholesterol (median change -8.8 mg/dL, p = .018), low-density lipoprotein cholesterol (median -9.5 mg/dL, p = .007), and triglycerides (median -19.8 mg/dL, p < .001). Our results show a favorable metabolic impact of DOR-based regimens along with a promising reduction in 10-year risk of cardiovascular disease.
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- 2022
24. Home Care Assistance: Has Covid-19 had an Impact on the Complex Management of HIV Patients?
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Dusina, Alex, Lombardi, Francesca, Tamburrini, Enrica, Onorati, Fiorella, Petrucci, Massimo, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Dusina, Alex, Lombardi, Francesca, Tamburrini, Enrica, Onorati, Fiorella, Petrucci, Massimo, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
During the COVID-19 pandemic, people living with HIV (PLWH) could have had to face problems with treatment adherence because of the difficulty of accessing services connected with antiretroviral therapy (ART) dispensation, which could have undermined their health. In this article, we described, over the period 2015-2020, both the activities of our home care assistance unit, the "Unita di Trattamento Domiciliare (UTD)", and the characteristics of the comorbid HIV patients followed-up. To determine whether the COVID-19 pandemic affected this service, we compared the number/type of services provided in 2020 with those provided in the preceding 5 years, i.e., 2015-2019. We also compared the proportion of monthly interventions carried out in 2018, 2019 and 2020. We found comparable values with some differences in the types of performances due to the heterogeneity of the population and their medical assistance needs. We also observed a stable viro-immunological status of the patients. All of these data suggest that the UTD was consistently active during the lockdown months and pandemic waves preventing therapy discontinuation, and was able to maintain optimal control of patients' HIV infections.
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- 2022
25. Differences in the Long-term Impact of the COVID-19 Pandemic on Mental Health and Professional Quality of Life of Resident and Specialist Physicians.
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DONNE, VALENTINA DELLE, MASSARONI, VALENTINA, CICCARELLI, NICOLETTA, BORGHETTI, ALBERTO, CICCULLO, ARTURO, BALDIN, GIANMARIA, GIULIANO, GABRIELE, DUSINA, ALEX, VISCONTI, ELENA, TAMBURRINI, ENRICA, and DI GIAMBENEDETTO, SIMONA
- Abstract
Background: The COVID-19 pandemic created a challenging situation for healthcare workers (HCWs) worldwide. We aimed to compare the mental health and professional quality of life of residents and specialist physicians in a cohort of Italian HCWs caring for patients with COVID-19 about two years after the start of the COVID-19 pandemic. Methods: Between November 2021 and November 2022, an online survey investigating the emotional states of depression, anxiety, stress, compassion satisfaction, and compassion fatigue was administered to HCWs (N=78) at the Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome. Results: Our findings suggest that from 5 to 20% of our HCWs still showed the effects of the adverse psychological impact of the pandemic, and more than half experienced medium levels of compassion fatigue and a medium level of compassion satisfaction. Our results also show that those with fewer years of clinical practice might be at greater risk of burnout (p=0.021), anxiety, and stress symptoms (both p=0.027). In addition, they might develop a lower level of compassion satisfaction (p=0.018). Moreover, the factors that potentially contribute to poor mental health, compassion fatigue, and compassion satisfaction differ between residents and specialist physicians. Conclusions: This overview presents one of the first pictures of the long-term effects of the pandemic on the mental health and professional quality of life of an Italian sample of HCWs. Moreover, it also helps identify professionals who most need support and emphasizes the importance of improving these individuals' psychological and professional well-being, especially during a pandemic-like crisis with long-lasting effects. [ABSTRACT FROM AUTHOR]
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- 2023
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26. Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumanniiin HIV and COVID 19 infected patient: A case report
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Passerotto, Rosa Anna, Lamanna, Francesco, Farinacci, Damiano, Dusina, Alex, Di Giambenedetto, Simona, Ciccullo, Arturo, and Borghetti, Alberto
- Abstract
We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii(MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy.
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- 2023
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27. Toxoplasmosis mimicking CMV chorioretinitis in newly diagnosed PLWH: a case report.
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Lamanna, Francesco, Passerotto, Rosa Anna, Carbone, Andrea, Steiner, Rebecca Jo, Iannone, Valentina, Salvo, Pierluigi Francesco, Ciccullo, Arturo, Baldin, Gianmaria, Borghetti, Alberto, and Dusina, Alex
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- 2023
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28. Short Communication: Comparing Lamivudine+Dolutegravir and Bictegravir/Emtricitabine/Tenofovir Alafenamide as Switch Strategies: Preliminary Results from Clinical Practice
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Baldin, Gianmaria, primary, Ciccullo, Arturo, additional, Lombardi, Francesca, additional, D'Angelillo, Anna, additional, Dusina, Alex, additional, Emiliozzi, Arianna, additional, Farinacci, Damiano, additional, Moschese, Davide, additional, Picarelli, Chiara, additional, Borghetti, Alberto, additional, and Di Giambenedetto, Simona, additional
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- 2021
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29. Short Communication: Efficacy and Safety of Dolutegravir Plus Lamivudine as a First-Line Regimen in Clinical Practice
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Ciccullo, Arturo, primary, Baldin, Gianmaria, additional, Dusina, Alex, additional, Cossu, Maria Vittoria, additional, Lombardi, Francesca, additional, Borghetti, Alberto, additional, Capetti, Amedeo, additional, and Di Giambenedetto, Simona, additional
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- 2021
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30. Risk of Tumor Onset in HIV+ Patients on Two-Drug Regimens: A Cohort Study in an Italian Hospital
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Borghetti, Alberto, primary, Bellino, Stefania, additional, Lombardi, Francesca, additional, Whalen, Matteo, additional, Belmonti, Simone, additional, Moschese, Davide, additional, Ciccullo, Arturo, additional, Tamburrini, Enrica, additional, Baldin, Gianmaria, additional, Dusina, Alex, additional, Visconti, Elena, additional, Emiliozzi, Arianna, additional, Lamonica, Silvia, additional, Pezzotti, Patrizio, additional, and Di Giambenedetto, Simona, additional
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- 2021
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31. Prevalence and factors associated with HIV-1 multi-drug resistance over the past two decades in the Italian ARCA database
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Lombardi, Francesca, Giacomelli, Andrea, Armenia, Daniele, Lai, Alessia, Dusina, Alex, Bezenchek, Antonia, Timelli, Laura, Saladini, Francesco, Vichi, Francesca, Corsi, Paola, Colao, Grazia, Bruzzone, Bianca, Gagliardini, Roberta, Callegaro, Annapaola, Castagna, Antonella, Santoro, Maria Mercedes, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Lombardi, Francesca, Giacomelli, Andrea, Armenia, Daniele, Lai, Alessia, Dusina, Alex, Bezenchek, Antonia, Timelli, Laura, Saladini, Francesco, Vichi, Francesca, Corsi, Paola, Colao, Grazia, Bruzzone, Bianca, Gagliardini, Roberta, Callegaro, Annapaola, Castagna, Antonella, Santoro, Maria Mercedes, and Lombardi, Francesca (ORCID:0000-0001-5757-8346)
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Despite successful antiretroviral therapy (ART), patients infected with human immunodeficiency virus (HIV) can develop multi-class drug resistance (MDR). This retrospective study aimed to explore the prevalence of HIV-1 drug resistance over the past two decades by focusing on HIV-MDR and its predictors. ART-experienced patients with HIV with results from at least one plasma genotypic resistance test (GRT) from 1998 to 2018, from the Antiviral Response Cohort Analysis database, were included in this study. The temporal trend of resistance to any drug class was evaluated by considering all GRTs. Prevalence and predictors of HIV-MDR were analysed by consideration of cumulative GRTs. Among 15 628 isolates from 6802 patients, resistance to at least one drug class decreased sharply from 1998 to 2010 (1998-2001: 78%; 2008-2010: 59%; P < 0.001) and then remained relatively constant at approximately 50% from 2011 to 2018, with the proportion of isolates with HIV-MDR also stable (approximately 9%).By evaluating factors associated with cumulative HIV-MDR, the following factors were found to be associated with increased risk of HIV-MDR on multi-variate analysis: male gender; sexual and vertical transmission; number of previous protease inhibitors, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and non-NRTIs; previous exposure to integrase strand transfer inhibitors, enfuvirtide and maraviroc; and co-infection with hepatitis B virus. In contrast, a nadir CD4 cell count >= 200 cells/mm3, starting first-line ART in 2008 or later and co-infection with hepatitis C virus were associated with lower risk of HIV-MDR. In conclusion, this study revealed that HIV-1 drug resistance has been stable since 2011 despite its dramatic decrease over the past two decades. HIV-MDR is still present, although at a lower rate, suggesting the need for continuous surveillance and accurate management of ART-experienced patients with HIV. (C) 2020 Elsevier Ltd and International Societ
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- 2021
32. Short Communication: Efficacy and Safety of Dolutegravir plus Lamivudine as a First-Line Regimen in Clinical Practice
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Ciccullo, A., Baldin, G., Dusina, Alex, Cossu, M. V., Lombardi, Francesca, Borghetti, Alberto, Capetti, A., Di Giambenedetto, Simona, Dusina A., Lombardi F. (ORCID:0000-0001-5757-8346), Borghetti A., DI Giambenedetto S. (ORCID:0000-0001-6990-5076), Ciccullo, A., Baldin, G., Dusina, Alex, Cossu, M. V., Lombardi, Francesca, Borghetti, Alberto, Capetti, A., Di Giambenedetto, Simona, Dusina A., Lombardi F. (ORCID:0000-0001-5757-8346), Borghetti A., and DI Giambenedetto S. (ORCID:0000-0001-6990-5076)
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The GEMINI trials have showed that the two drugs regimen of dolutegravir+lamivudine (DTG +3TC) was noninferior to a three-drug regimen as a first line regimen for treatment-naive people living with HIV. The aim of our study was to confirm, in a real-life setting, the efficacy of this regimen. We conducted a retrospective, observational study enrolling treatment-naive patients starting a first-line regimen with lamivudine plus dolutegravir. We evaluated the virological efficacy and the immunological and metabolic profiles. Changes from baseline were evaluated through linear-mixed models for repeated measures. Linear regression analyses were performed to explore variables associated to significant changes in laboratory parameters. We analyzed a total of 20 patients: 15 (75%) were men with a median age of 34.5 years. During a cumulative time of 15.4 patients years of follow up (PYFU), we did not observe any adverse event or treatment discontinuation and all patients achieved virological suppression in the first 6 months from treatment initiation. Increase in CD4+ cells was significant at both week 24 (p = .003) and week 48 (p = .007) of follow-up. Moreover, CD4/CD8 ratio also significantly improved [median increase of +0.22 (p = .028) after 48 weeks of follow-up]. As to metabolic parameters, we observed no significant changes in total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. In a subgroup of 11 patients, we further investigate HIV-1 DNA variations. Our results are in line with the findings of the GEMINI trials, confirming the efficacy and safety of DTG +3TC in treatment-naive patients.
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- 2021
33. Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients during Lamivudine plus Dolutegravir Maintenance Therapy in Clinical Practice
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Borghetti, Alberto, Giacomelli, A., Borghi, V., Ciccullo, A., Dusina, Alex, Fabbiani, M., Rusconi, S., Zazzi, M., Mussini, C., Di Giambenedetto, Simona, Borghetti A., Dusina A., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Borghetti, Alberto, Giacomelli, A., Borghi, V., Ciccullo, A., Dusina, Alex, Fabbiani, M., Rusconi, S., Zazzi, M., Mussini, C., Di Giambenedetto, Simona, Borghetti A., Dusina A., and Di Giambenedetto S. (ORCID:0000-0001-6990-5076)
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The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VFs). In this dataset from clinical practice investigating the impact of past nucleoside reverse-transcriptase inhibitor resistance on this strategy, the combination of M184V/I plus at least 1 thymidine analog-associated mutation significantly increased the risk of VF.
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- 2021
34. Short Communication: Comparing Lamivudine+Dolutegravir and Bictegravir/Emtricitabine/Tenofovir Alafenamide as Switch Strategies: Preliminary Results from Clinical Practice
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Baldin, G., Ciccullo, A., Lombardi, Francesca, D'Angelillo, Anna, Dusina, Alex, Emiliozzi, A., Farinacci, Damiano, Moschese, D., Picarelli, C., Borghetti, Alberto, Di Giambenedetto, Simona, Lombardi F. (ORCID:0000-0001-5757-8346), D'Angelillo A., Dusina A., Farinacci D., Borghetti A., DI Giambenedetto S. (ORCID:0000-0001-6990-5076), Baldin, G., Ciccullo, A., Lombardi, Francesca, D'Angelillo, Anna, Dusina, Alex, Emiliozzi, A., Farinacci, Damiano, Moschese, D., Picarelli, C., Borghetti, Alberto, Di Giambenedetto, Simona, Lombardi F. (ORCID:0000-0001-5757-8346), D'Angelillo A., Dusina A., Farinacci D., Borghetti A., and DI Giambenedetto S. (ORCID:0000-0001-6990-5076)
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We tried to investigate and compare the safety of a dual therapy (DT) with dolutegravir+lamivudine (DTG +3TC) versus bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). We performed a retrospective analysis in a cohort of virologically suppressed HIV+ pts switching to DT or BIC in our center. Primary endpoint was to evaluate time to treatment discontinuation (TD) for any cause. Survival analysis was employed to determine time to TD and its predictors were analyzed by Cox regression. Moreover, we collected viro-immunological parameters as well as markers of renal function and lipid profile at baseline and after 24 weeks and assessed changes through nonparametric tests. We analyzed 476 patients: 350 starting a DT and 126 starting BIC. Overall, we registered 21 TD: 15 in the DT group during 170 patient-years of follow-up (PYFU) (a rate of 8.8 per 100 PYFU) and 6 in the BIC one during 48 PYFU (12.5 per 100 PYFU). Estimated probabilities of maintaining study regimen after 24 weeks were 95.5% [standard deviation (SD) ±1.1] in the DT group and 94.9% (SD ±2.0) in the BIC group, with no significant differences between them (log-rank p = .639). Concerning metabolic profile, in the DT group, after 24 weeks, triglycerides decreased significantly (median change -14 mg/dL, p < .001), whereas high-density lipoprotein cholesterol increased (+3 mg/dL, p = .031). In the BIC group, meanwhile, we observed a significant decrease in low-density lipoprotein cholesterol after 24 weeks (-13 mg/dL, p = .026). Both optimization strategies showed high tolerability in the short term in experienced pts, with few differences between them. Further studies are needed to properly assess the matter.
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- 2021
35. Efficacy and durability of two- vs. three-drug integrase inhibitor-based regimens in virologically suppressed HIV-infected patients: Data from real-life ODOACRE cohort
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Fabbiani, M., Rossetti, Barbara, Ciccullo, A., Oreni, L., Lagi, F., Celani, L., Colafigli, Manuela, De Vito, Antonio, Mazzitelli, M., Dusina, Alex, Durante, Miriana, Montagnani, F., Rusconi, S., Capetti, A., Sterrantino, G., D'Ettorre, G., Di Giambenedetto, Simona, Zanelli, G., Baldin, G., Borghetti, Alberto, Latini, A., Mastroianni, Chiara, Borghi, V., Mussini, C., Cossu, M. V., Giacomelli, A., Formenti, T., Trecarichi, Enrico Maria, Torti, Carlo, Madeddu, G., Vecchiet, J., Vignale, F., Giacometti, A., Rossetti B., Colafigli M., De Vito A., Dusina A., Durante M., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Borghetti A., Mastroianni C., Trecarichi E. M., Torti C., Fabbiani, M., Rossetti, Barbara, Ciccullo, A., Oreni, L., Lagi, F., Celani, L., Colafigli, Manuela, De Vito, Antonio, Mazzitelli, M., Dusina, Alex, Durante, Miriana, Montagnani, F., Rusconi, S., Capetti, A., Sterrantino, G., D'Ettorre, G., Di Giambenedetto, Simona, Zanelli, G., Baldin, G., Borghetti, Alberto, Latini, A., Mastroianni, Chiara, Borghi, V., Mussini, C., Cossu, M. V., Giacomelli, A., Formenti, T., Trecarichi, Enrico Maria, Torti, Carlo, Madeddu, G., Vecchiet, J., Vignale, F., Giacometti, A., Rossetti B., Colafigli M., De Vito A., Dusina A., Durante M., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Borghetti A., Mastroianni C., Trecarichi E. M., and Torti C.
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Objectives: The aim of the present study was to compare the efficacy and durability of treatment switch to two-drug (2DR) vs. three-drug (3DR) integrase inhibitor (InSTI)-based regimens in a real-life setting. Methods: Within the ODOACRE cohort, we selected adult patients with HIV RNA < 50 copies/mL switching to an InSTI-based 2DR or 3DR. Survival analyses were performed to estimate the probability of virological failure (VF, defined as one HIV RNA > 1000 copies/mL or two consecutive HIV RNA > 50 copies/mL) and treatment discontinuation (TD, defined as any modification, intensification or interruption of the regimen), and to evaluate their predictors. Results: Overall, 1666 patients were included, of whom 1334 (80%) were treated with a 3DR (19.9%, 25.0% and 55.1% elvitegravir-, raltegravir- and dolutegravir-based, respectively) and 332 (20%) with a 2DR (79.2% dolutegravir + lamivudine and 20.8% dolutegravir + rilpivirine). Over a median (interquartile range) follow-up of 100 (52–150) weeks, 52 (3.1%) patients experienced VF with an incidence of 1.5/100 person-year of follow-up (PYFU). The estimated 96-week probability of VF was similar for the 2DR and 3DR groups (2.3% vs. 2.8%, P = 0.53), but it was higher for elvitegravir (4.9%) and raltegravir (5.0%) than for dolutegravir (1.5%) (P = 0.04). Four hundred (24%) patients discontinued their InSTI-based regimen, with an incidence of 11.3/100 PYFU. At 96 weeks, 3DRs showed a higher probability of TD for any reason (20.6% vs. 11.2%, P < 0.001) and TD for toxicity (9.0% vs. 6.6%, P = 0.02) when compared with 2DRs. A higher risk of TD for central nervous system toxicity was observed for dolutegravir than for elvitegravir and raltegravir (4.0% vs. 2.5% vs. 0.6%, P = 0.005). Conclusions: In virologically suppressed HIV-infected patients, 2DRs showed an efficacy similar to 3DRs but with better to
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- 2021
36. The need to continue testing for HIV, even during the coronavirus disease 2019 (COVID-19) pandemic
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Ciccullo, A., Borghetti, Alberto, Dusina, Alex, Segala, Francesco Vladimiro, Visconti, Elena, Tamburrini, Enrica, Cauda, Roberto, Di Giambenedetto, Simona, Borghetti A., Dusina A., Segala F. V., Visconti E., Tamburrini E. (ORCID:0000-0003-4930-426X), Cauda R. (ORCID:0000-0002-1498-4229), Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Ciccullo, A., Borghetti, Alberto, Dusina, Alex, Segala, Francesco Vladimiro, Visconti, Elena, Tamburrini, Enrica, Cauda, Roberto, Di Giambenedetto, Simona, Borghetti A., Dusina A., Segala F. V., Visconti E., Tamburrini E. (ORCID:0000-0003-4930-426X), Cauda R. (ORCID:0000-0002-1498-4229), and Di Giambenedetto S. (ORCID:0000-0001-6990-5076)
- Abstract
N/A Not Available
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- 2021
37. Virological outcomes with dolutegravir plus either lamivudine or two NRTIs as switch strategies: a multi-cohort study
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Borghetti, Alberto, Alkhatib, M, Dusina, Alex, Duca, L, Borghi, V, Zazzi, M, Di Giambenedetto, Simona, Borghetti, A, Dusina, A, Di Giambenedetto, S (ORCID:0000-0001-6990-5076), Borghetti, Alberto, Alkhatib, M, Dusina, Alex, Duca, L, Borghi, V, Zazzi, M, Di Giambenedetto, Simona, Borghetti, A, Dusina, A, and Di Giambenedetto, S (ORCID:0000-0001-6990-5076)
- Abstract
Objectives: To compare the efficacy of dolutegravir plus lamivudine dual therapy (DT) with that of dolutegravir plus two NRTIs triple therapy (TT) as switch strategies. Methods: A multicentre cohort of HIV-positive, HBsAg-negative patients with viral suppression (HIV-RNA ≤50 copies/mL) switching to DT or TT was retrospectively selected from the ARCA database. The effect of DT versus TT on virological failure (VF; defined as two consecutive HIV-RNA values >50 copies/mL or one HIV-RNA value ≥200 copies/mL) was evaluated by multivariable Cox regression models, overall and after stratifying for the presence of NRTI resistance-associated mutations (RAMs). Results: From December 2014 to June 2020, 628 patients were eligible: 118 (18.8%) started tenofovir/emtricitabine/dolutegravir, 306 (48.7%) abacavir/lamivudine/dolutegravir and 204 (32.5%) lamivudine/dolutegravir. The DT group had significantly higher nadir and baseline CD4 counts, a higher duration of viral suppression and a lower prevalence of RAMs at historical genotype. Overall, 41 VF occurred after a median of 1.7 years of follow-up, with a lower, but not statistically significant, rate for DT [versus TT, adjusted HR (aHR) = 0.58, 95% CI = 0.25-1.34]. However, DT was associated with less VF in the absence of RAMs when compared with tenofovir-based TT (aHR = 0.20, 95% CI = 0.06-0.67), but not with abacavir-based TT (aHR = 0.43, 95% CI = 0.17-1.11). Conversely, in the setting of pre-existing M184V/I, DT showed a trend to increased risk of VF (versus tenofovir-based TT, aHR = 137.50, 95% CI = 4.24-4464.06; versus abacavir-based TT, aHR = 33.88, 95% CI = 1.75-656.47). Conclusions: Lamivudine/dolutegravir maintenance DT showed similar efficacy to dolutegravir-based TT; however, past M184V/I may favour VF.
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- 2021
38. Risk of Tumor Onset in HIV+ Patients on Two-Drug Regimens: A Cohort Study in an Italian Hospital
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Borghetti, Alberto, Bellino, S., Lombardi, Francesca, Whalen, Matteo Bernard, Belmonti, S., Moschese, D., Ciccullo, A., Tamburrini, Enrica, Baldin, G., Dusina, Alex, Visconti, Elena, Emiliozzi, A., Lamonica, S., Pezzotti, Patrizio, Di Giambenedetto, Simona, Borghetti A., Lombardi F. (ORCID:0000-0001-5757-8346), Whalen M., Tamburrini E. (ORCID:0000-0003-4930-426X), Dusina A., Visconti E., Pezzotti P., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Borghetti, Alberto, Bellino, S., Lombardi, Francesca, Whalen, Matteo Bernard, Belmonti, S., Moschese, D., Ciccullo, A., Tamburrini, Enrica, Baldin, G., Dusina, Alex, Visconti, Elena, Emiliozzi, A., Lamonica, S., Pezzotti, Patrizio, Di Giambenedetto, Simona, Borghetti A., Lombardi F. (ORCID:0000-0001-5757-8346), Whalen M., Tamburrini E. (ORCID:0000-0003-4930-426X), Dusina A., Visconti E., Pezzotti P., and Di Giambenedetto S. (ORCID:0000-0001-6990-5076)
- Abstract
Currently approved 2-drug therapies are as effective as 3-drug regimens but could potentially lead to increased cancer risk due to less efficient immune recovery. We conducted a longitudinal cohort study in a tertiary Italian hospital to investigate HIV+ patients starting a triple therapy (TT) (2 NRTIs +3rd agent) or a dual therapy (DT) (3TC/FTC+boosted-PI, boosted-DRV+RAL, and 3TC/FTC or RPV+DTG) regimen between 2009 and 2018. The effect of DT (vs. TT) on tumor onset was evaluated by the multivariable Cox regression and the marginal structural Cox model, after estimating the inverse probability of treatment weights (IPTW). One thousand one hundred and seven patients who had a median follow-up of 4.2 person-years (py) were evaluated; 69.2% were males, with a median age of 43 years. Overall 2,513 treatments were started during the study period (479 DT, 2,034 TT). Eight tumors occurred over 965 py with DT and 35 over 3,817 py during TT (p = .797). In the Cox regression, DT did not predict an increased risk of tumor compared with TT (HR 1.14; p = .757) after adjusting for potential confounders. A marginal structural model using IPTW (HR 0.68; p = .328) and stabilized IPTW (HR 0.69; p = .361) confirmed this result. Preliminary findings from our cohort do not suggest an increased risk of tumors with DT compared to TT.
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- 2021
39. COVID-19 and intestinal inflammation: Role of fecal calprotectin
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Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, D'Addio, Stefano, D'Alessandro, Alessia, D'AlfonsoD'Angelo, Maria ElenaEmanuela, D'Aversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, Dell'Anna, Antonio Maria, Polla, Davide Della, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Monaco, Maria Rita Lo, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Dal Verme, Lorenzo Zileri, Zuccalà, Giuseppe, and Troiani, Eliana
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- 2020
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40. Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice
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Borghetti, Alberto, primary, Giacomelli, Andrea, additional, Borghi, Vanni, additional, Ciccullo, Arturo, additional, Dusina, Alex, additional, Fabbiani, Massimiliano, additional, Rusconi, Stefano, additional, Zazzi, Maurizio, additional, Mussini, Cristina, additional, and Di Giambenedetto, Simona, additional
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- 2021
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41. Prevalence and factors associated with HIV-1 multi-drug resistance over the past two decades in the Italian ARCA database
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Lombardi, Francesca, primary, Giacomelli, Andrea, additional, Armenia, Daniele, additional, Lai, Alessia, additional, Dusina, Alex, additional, Bezenchek, Antonia, additional, Timelli, Laura, additional, Saladini, Francesco, additional, Vichi, Francesca, additional, Corsi, Paola, additional, Colao, Grazia, additional, Bruzzone, Bianca, additional, Gagliardini, Roberta, additional, Callegaro, Annapaola, additional, Castagna, Antonella, additional, and Santoro, Maria Mercedes, additional
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- 2021
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42. Assessment of neurological manifestations in hospitalized patients with COVID-19
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Luigetti, M., Iorio, R., Bentivoglio, A. R., Tricoli, L., Riso, V., Marotta, J., Piano, C., Primiano, G., Zileri Del Verme, L., Lo Monaco, M. R., Calabresi, P., Abbate, Valeria, Acampora, Nicola, Addolorato, Giovanni, Agostini, Fabiana, Ainora, Maria Elena, Akacha, Karim, Amato, Elena, Andreani, Francesca, Andriollo, Gloria, Annetta, Maria Giuseppina, Annicchiarico, Brigida Eleonora, Antonelli, Mariangela, Antonucci, Gabriele, Anzellotti, Gian Marco, Armuzzi, Alessandro, Baldi, Fabiana, Barattucci, Ilaria, Barillaro, Christian, Barone, Fabiana, Bellantone, Rocco Domenico Alfonso, Bellieni, Andrea, Bello, Giuseppe, Benicchi, Andrea, Benvenuto, Francesca, Berardini, Ludovica, Berloco, Filippo, Bernabei, Roberto, Bianchi, Antonio, Biasucci, Daniele Guerino, Biasucci, Luigi Marzio, Bibbò, Stefano, Bini, Alessandra, Bisanti, Alessandra, Biscetti, Federico, Bocci, Maria Grazia, Bonadia, Nicola, Bongiovanni, Filippo, Borghetti, Alberto, Bosco, Giulia, Bosello, Silvia, Bove, Vincenzo, Bramato, Giulia, Brandi, Vincenzo, Bruni, Teresa, Bruno, Carmine, Bruno, Dario, Bungaro, Maria Chiara, Buonomo, Alessandro, Burzo, Livia, Calabrese, Angelo, Calvello, Maria Rosaria, Cambieri, Andrea, Cambise, Chiara, Cammà, Giulia, Candelli, Marcello, Canistro, Gennaro, Cantanale, Antonello, Capalbo, Gennaro, Capaldi, Lorenzo, Capone, Emanuele, Capristo, Esmeralda, Carbone, Luigi, Cardone, Silvia, Carelli, Simone, Carfì, Angelo, Carnicelli, Annamaria, Caruso, Cristiano, Casciaro, Francesco Antonio, Catalano, Lucio, Cauda, Roberto, Cecchini, Andrea Leonardo, Cerrito, Lucia, Cesarano, Melania, Chiarito, Annalisa, Cianci, Rossella, Cicchinelli, Sara, Ciccullo, Arturo, Cicetti, Marta, Ciciarello, Francesca, Cingolani, Antonella, Cipriani, Maria Camilla, Consalvo, Maria Ludovica, Coppola, Gaetano, Corbo, Giuseppe Maria, Corsello, Andrea, Costante, Federico, Costanzi, Matteo, Covino, Marcello, Crupi, Davide, Cutuli, Salvatore Lucio, DAddio, Stefano, DAlessandro, Alessia, DAlfonso, Maria Elena, DAngelo, Emanuela, DAversa, Francesca, Damiano, Fernando, De Berardinis, Gian Maria, De Cunzo, Tommaso, De Gaetano, Donati Katleen, De Luca, Giulio, De Matteis, Giuseppe, De Pascale, Gennaro, De Santis, Paolo, De Siena, Martina, De Vito, Francesco, Del Gatto, Valeria, Del Giacomo, Paola, Del Zompo, Fabio, DellAnna, Antonio Maria, Della, Polla Davide, Di Gialleonardo, Luca, Di Giambenedetto, Simona, Di Luca, Roberta, Di Maurizio, Luca, Di Muro, Mariangela, Dusina, Alex, Eleuteri, Davide, Esperide, Alessandra, Fachechi, Daniele, Faliero, Domenico, Falsiroli, Cinzia, Fantoni, Massimo, Fedele, Annalaura, Feliciani, Daniela, Ferrante, Cristina, Ferrone, Giuliano, Festa, Rossano, Fiore, Maria Chiara, Flex, Andrea, Forte, Evelina, Franceschi, Francesco, Francesconi, Alessandra, Franza, Laura, Funaro, Barbara, Fuorlo, Mariella, Fusco, Domenico, Gabrielli, Maurizio, Gaetani, Eleonora, Galletta, Claudia, Gallo, Antonella, Gambassi, Giovanni, Garcovich, Matteo, Gasbarrini, Antonio, Gasparrini, Irene, Gelli, Silvia, Giampietro, Antonella, Gigante, Laura, Giuliano, Gabriele, Giuliano, Giorgia, Giupponi, Bianca, Gremese, Elisa, Grieco, Domenico Luca, Guerrera, Manuel, Guglielmi, Valeria, Guidone, Caterina, Gullì, Antonio, Iaconelli, Amerigo, Iafrati, Aurora, Ianiro, Gianluca, Iaquinta, Angela, Impagnatiello, Michele, Inchingolo, Riccardo, Intini, Enrica, Iorio, Raffaele, Izzi, Immacolata Maria, Jovanovic, Tamara, Kadhim, Cristina, La Macchia, Rosa, La Milia, Daniele Ignazio, Landi, Francesco, Landi, Giovanni, Landi, Rosario, Landolfi, Raffaele, Leo, Massimo, Leone, Paolo Maria, Levantesi, Laura, Liguori, Antonio, Liperoti, Rosa, Lizzio, Marco Maria, Lo Monaco Maria, Rita, Locantore, Pietro, Lombardi, Francesco, Lombardi, Gianmarco, Lopetuso, Loris, Loria, Valentina, Losito, Angela Raffaella, Lucia, Mothanje Barbara Patricia, Macagno, Francesco, Macerola, Noemi, Maggi, Giampaolo, Maiuro, Giuseppe, Mancarella, Francesco, Mangiola, Francesca, Manno, Alberto, Marchesini, Debora, Maresca, Gian Marco, Marrone, Giuseppe, Martis, Ilaria, Martone, Anna Maria, Marzetti, Emanuele, Mattana, Chiara, Matteo, Maria Valeria, Maviglia, Riccardo, Mazzarella, Ada, Memoli, Carmen, Miele, Luca, Migneco, Alessio, Mignini, Irene, Milani, Alessandro, Milardi, Domenico, Montalto, Massimo, Montemurro, Giuliano, Monti, Flavia, Montini, Luca, Morena, Tony Christian, Morra, Vincenzina, Morretta, Chiara, Moschese, Davide, Murace, Celeste Ambra, Murdolo, Martina, Murri, Rita, Napoli, Marco, Nardella, Elisabetta, Natalello, Gerlando, Natalini, Daniele, Navarra, Simone Maria, Nesci, Antonio, Nicoletti, Alberto, Nicoletti, Rocco, Nicoletti, Tommaso Filippo, Nicolò, Rebecca, Nicolotti, Nicola, Nista, Enrico Celestino, Nuzzo, Eugenia, Oggiano, Marco, Ojetti, Veronica, Pagano, Francesco Cosimo, Paiano, Gianfranco, Pais, Cristina, Pallavicini, Federico, Palombo, Andrea, Paolillo, Federico, Papa, Alfredo, Papanice, Domenico, Papparella, Luigi Giovanni, Paratore, Mattia, Parrinello, Giuseppe, Pasciuto, Giuliana, Pasculli, Pierpaolo, Pecorini, Giovanni, Perniola, Simone, Pero, Erika, Petricca, Luca, Petrucci, Martina, Picarelli, Chiara, Piccioni, Andrea, Piccolo, Annalisa, Piervincenzi, Edoardo, Pignataro, Giulia, Pignataro, Raffaele, Pintaudi, Gabriele, Pisapia, Luca, Pizzoferrato, Marco, Pizzolante, Fabrizio, Pola, Roberto, Policola, Caterina, Pompili, Maurizio, Pontecorvi, Flavia, Pontecorvi, Valerio, Ponziani, Francesca, Popolla, Valentina, Porceddu, Enrica, Porfidia, Angelo, Porro, Lucia Maria, Potenza, Annalisa, Pozzana, Francesca, Privitera, Giuseppe, Pugliese, Daniela, Pulcini, Gabriele, Racco, Simona, Raffaelli, Francesca, Ramunno, Vittoria, Rapaccini, Gian Ludovico, Richeldi, Luca, Rinninella, Emanuele, Rocchi, Sara, Romanò, Bruno, Romano, Stefano, Rosa, Federico, Rossi, Laura, Rossi, Raimondo, Rossini, Enrica, Rota, Elisabetta, Rovedi, Fabiana, Rubino, Carlotta, Rumi, Gabriele, Russo, Andrea, Sabia, Luca, Salerno, Andrea, Salini, Sara, Salvatore, Lucia, Samori, Dehara, Sandroni, Claudio, Sanguinetti, Maurizio, Santarelli, Luca, Santini, Paolo, Santolamazza, Danilo, Santoliquido, Angelo, Santopaolo, Francesco, Santoro, Michele Cosimo, Sardeo, Francesco, Sarnari, Caterina, Saviano, Angela, Saviano, Luisa, Scaldaferri, Franco, Scarascia, Roberta, Schepis, Tommaso, Schiavello, Francesca, Scoppettuolo, Giancarlo, Sedda, Davide, Sessa, Flaminio, Sestito, Luisa, Settanni, Carlo, Siciliano, Matteo, Siciliano, Valentina, Sicuranza, Rossella, Simeoni, Benedetta, Simonetti, Jacopo, Smargiassi, Andrea, Soave, Paolo Maurizio, Sonnino, Chiara, Staiti, Domenico, Stella, Claudia, Stella, Leonardo, Stival, Eleonora, Taddei, Eleonora, Talerico, Rossella, Tamburello, Elio, Tamburrini, Enrica, Tanzarella, Eloisa Sofia, Tarascio, Elena, Tarli, Claudia, Tersali, Alessandra, Tilli, Pietro, Timpano, Jacopo, Torelli, Enrico, Torrini, Flavia, Tosato, Matteo, Tosoni, Alberto, Tricoli, Luca, Tritto, Marcello, Tumbarello, Mario, Tummolo, Anita Maria, Vallecoccia, Maria Sole, Valletta, Federico, Varone, Francesco, Vassalli, Francesco, Ventura, Giulio, Verardi, Lucrezia, Vetrone, Lorenzo, Vetrugno, Giuseppe, Visconti, Elena, Visconti, Felicia, Viviani, Andrea, Zaccaria, Raffaella, Zaccone, Carmelina, Zelano, Lorenzo, Zileri Dal Verme, Lorenzo, and Zuccalà, Giuseppe
- Subjects
Male ,Hospitalized patients ,muscle ,Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA ,neurological disorders ,0302 clinical medicine ,Hyposmia ,030212 general & internal medicine ,Respiratory system ,education.field_of_study ,Brain Diseases ,Headache ,virus diseases ,Neuromuscular Diseases ,Middle Aged ,Hospitalization ,medicine.anatomical_structure ,Neurology ,Female ,medicine.symptom ,Adult ,medicine.medical_specialty ,SARS‐CoV2 ,Coronavirus disease 2019 (COVID-19) ,Patients ,Short Communication ,Anosmia ,precision medicine ,Population ,Encephalopathy ,Short Communications ,Clinical Neurology ,Settore MED/26 ,03 medical and health sciences ,COVID‐19 ,Internal medicine ,Throat ,Influenza, Human ,medicine ,Humans ,education ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,Hypoxia (medical) ,medicine.disease ,respiratory tract diseases ,body regions ,Neurology (clinical) ,Nervous System Diseases ,business ,030217 neurology & neurosurgery - Abstract
Background and purpose The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
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- 2020
43. COVID-19 and intestinal inflammation: Role of fecal calprotectin
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Ojetti, Veronica, primary, Saviano, Angela, additional, Covino, Marcello, additional, Acampora, Nicola, additional, Troiani, Eliana, additional, Franceschi, Francesco, additional, Abbate, Valeria, additional, Addolorato, Giovanni, additional, Agostini, Fabiana, additional, Ainora, Maria Elena, additional, Akacha, Karim, additional, Amato, Elena, additional, Andreani, Francesca, additional, Andriollo, Gloria, additional, Annetta, Maria Giuseppina, additional, Annicchiarico, Brigida Eleonora, additional, Antonelli, Mariangela, additional, Antonucci, Gabriele, additional, Anzellotti, Gian Marco, additional, Armuzzi, Alessandro, additional, Baldi, Fabiana, additional, Barattucci, Ilaria, additional, Barillaro, Christian, additional, Barone, Fabiana, additional, Bellantone, Rocco Domenico Alfonso, additional, Bellieni, Andrea, additional, Bello, Giuseppe, additional, Benicchi, Andrea, additional, Benvenuto, Francesca, additional, Berardini, Ludovica, additional, Berloco, Filippo, additional, Bernabei, Roberto, additional, Bianchi, Antonio, additional, Biasucci, Daniele Guerino, additional, Biasucci, Luigi Marzio, additional, Bibbò, Stefano, additional, Bini, Alessandra, additional, Bisanti, Alessandra, additional, Biscetti, Federico, additional, Bocci, Maria Grazia, additional, Bonadia, Nicola, additional, Bongiovanni, Filippo, additional, Borghetti, Alberto, additional, Bosco, Giulia, additional, Bosello, Silvia, additional, Bove, Vincenzo, additional, Bramato, Giulia, additional, Brandi, Vincenzo, additional, Bruni, Teresa, additional, Bruno, Carmine, additional, Bruno, Dario, additional, Bungaro, Maria Chiara, additional, Buonomo, Alessandro, additional, Burzo, Livia, additional, Calabrese, Angelo, additional, Calvello, Maria Rosaria, additional, Cambieri, Andrea, additional, Cambise, Chiara, additional, Cammà, Giulia, additional, Candelli, Marcello, additional, Canistro, Gennaro, additional, Cantanale, Antonello, additional, Capalbo, Gennaro, additional, Capaldi, Lorenzo, additional, Capone, Emanuele, additional, Capristo, Esmeralda, additional, Carbone, Luigi, additional, Cardone, Silvia, additional, Carelli, Simone, additional, Carfì, Angelo, additional, Carnicelli, Annamaria, additional, Caruso, Cristiano, additional, Casciaro, Francesco Antonio, additional, Catalano, Lucio, additional, Cauda, Roberto, additional, Cecchini, Andrea Leonardo, additional, Cerrito, Lucia, additional, Cesarano, Melania, additional, Chiarito, Annalisa, additional, Cianci, Rossella, additional, Cicchinelli, Sara, additional, Ciccullo, Arturo, additional, Cicetti, Marta, additional, Ciciarello, Francesca, additional, Cingolani, Antonella, additional, Cipriani, Maria Camilla, additional, Consalvo, Maria Ludovica, additional, Coppola, Gaetano, additional, Corbo, Giuseppe Maria, additional, Corsello, Andrea, additional, Costante, Federico, additional, Costanzi, Matteo, additional, Crupi, Davide, additional, Cutuli, Salvatore Lucio, additional, D'Addio, Stefano, additional, D'Alessandro, Alessia, additional, D'AlfonsoD'Angelo, Maria ElenaEmanuela, additional, D'Aversa, Francesca, additional, Damiano, Fernando, additional, De Berardinis, Gian Maria, additional, De Cunzo, Tommaso, additional, De Gaetano, Donati Katleen, additional, De Luca, Giulio, additional, De Matteis, Giuseppe, additional, De Pascale, Gennaro, additional, De Santis, Paolo, additional, De Siena, Martina, additional, De Vito, Francesco, additional, Del Gatto, Valeria, additional, Del Giacomo, Paola, additional, Del Zompo, Fabio, additional, Dell'Anna, Antonio Maria, additional, Polla, Davide Della, additional, Di Gialleonardo, Luca, additional, Di Giambenedetto, Simona, additional, Di Luca, Roberta, additional, Di Maurizio, Luca, additional, Di Muro, Mariangela, additional, Dusina, Alex, additional, Eleuteri, Davide, additional, Esperide, Alessandra, additional, Fachechi, Daniele, additional, Faliero, Domenico, additional, Falsiroli, Cinzia, additional, Fantoni, Massimo, additional, Fedele, Annalaura, additional, Feliciani, Daniela, additional, Ferrante, Cristina, additional, Ferrone, Giuliano, additional, Festa, Rossano, additional, Fiore, Maria Chiara, additional, Flex, Andrea, additional, Forte, Evelina, additional, Francesconi, Alessandra, additional, Franza, Laura, additional, Funaro, Barbara, additional, Fuorlo, Mariella, additional, Fusco, Domenico, additional, Gabrielli, Maurizio, additional, Gaetani, Eleonora, additional, Galletta, Claudia, additional, Gallo, Antonella, additional, Gambassi, Giovanni, additional, Garcovich, Matteo, additional, Gasbarrini, Antonio, additional, Gasparrini, Irene, additional, Gelli, Silvia, additional, Giampietro, Antonella, additional, Gigante, Laura, additional, Giuliano, Gabriele, additional, Giuliano, Giorgia, additional, Giupponi, Bianca, additional, Gremese, Elisa, additional, Grieco, Domenico Luca, additional, Guerrera, Manuel, additional, Guglielmi, Valeria, additional, Guidone, Caterina, additional, Gullì, Antonio, additional, Iaconelli, Amerigo, additional, Iafrati, Aurora, additional, Ianiro, Gianluca, additional, Iaquinta, Angela, additional, Impagnatiello, Michele, additional, Inchingolo, Riccardo, additional, Intini, Enrica, additional, Iorio, Raffaele, additional, Izzi, Immacolata Maria, additional, Jovanovic, Tamara, additional, Kadhim, Cristina, additional, La Macchia, Rosa, additional, La Milia, Daniele Ignazio, additional, Landi, Francesco, additional, Landi, Giovanni, additional, Landi, Rosario, additional, Landolfi, Raffaele, additional, Leo, Massimo, additional, Leone, Paolo Maria, additional, Levantesi, Laura, additional, Liguori, Antonio, additional, Liperoti, Rosa, additional, Lizzio, Marco Maria, additional, Monaco, Maria Rita Lo, additional, Locantore, Pietro, additional, Lombardi, Francesco, additional, Lombardi, Gianmarco, additional, Lopetuso, Loris, additional, Loria, Valentina, additional, Losito, Angela Raffaella, additional, Lucia, Mothanje Barbara Patricia, additional, Macagno, Francesco, additional, Macerola, Noemi, additional, Maggi, Giampaolo, additional, Maiuro, Giuseppe, additional, Mancarella, Francesco, additional, Mangiola, Francesca, additional, Manno, Alberto, additional, Marchesini, Debora, additional, Maresca, Gian Marco, additional, Marrone, Giuseppe, additional, Martis, Ilaria, additional, Martone, Anna Maria, additional, Marzetti, Emanuele, additional, Mattana, Chiara, additional, Matteo, Maria Valeria, additional, Maviglia, Riccardo, additional, Mazzarella, Ada, additional, Memoli, Carmen, additional, Miele, Luca, additional, Migneco, Alessio, additional, Mignini, Irene, additional, Milani, Alessandro, additional, Milardi, Domenico, additional, Montalto, Massimo, additional, Montemurro, Giuliano, additional, Monti, Flavia, additional, Montini, Luca, additional, Morena, Tony Christian, additional, Morra, Vincenzina, additional, Morretta, Chiara, additional, Moschese, Davide, additional, Murace, Celeste Ambra, additional, Murdolo, Martina, additional, Murri, Rita, additional, Napoli, Marco, additional, Nardella, Elisabetta, additional, Natalello, Gerlando, additional, Natalini, Daniele, additional, Navarra, Simone Maria, additional, Nesci, Antonio, additional, Nicoletti, Alberto, additional, Nicoletti, Rocco, additional, Nicoletti, Tommaso Filippo, additional, Nicolò, Rebecca, additional, Nicolotti, Nicola, additional, Nista, Enrico Celestino, additional, Nuzzo, Eugenia, additional, Oggiano, Marco, additional, Ojetti, Veronica, additional, Pagano, Francesco Cosimo, additional, Paiano, Gianfranco, additional, Pais, Cristina, additional, Pallavicini, Federico, additional, Palombo, Andrea, additional, Paolillo, Federico, additional, Papa, Alfredo, additional, Papanice, Domenico, additional, Papparella, Luigi Giovanni, additional, Paratore, Mattia, additional, Parrinello, Giuseppe, additional, Pasciuto, Giuliana, additional, Pasculli, Pierpaolo, additional, Pecorini, Giovanni, additional, Perniola, Simone, additional, Pero, Erika, additional, Petricca, Luca, additional, Petrucci, Martina, additional, Picarelli, Chiara, additional, Piccioni, Andrea, additional, Piccolo, Annalisa, additional, Piervincenzi, Edoardo, additional, Pignataro, Giulia, additional, Pignataro, Raffaele, additional, Pintaudi, Gabriele, additional, Pisapia, Luca, additional, Pizzoferrato, Marco, additional, Pizzolante, Fabrizio, additional, Pola, Roberto, additional, Policola, Caterina, additional, Pompili, Maurizio, additional, Pontecorvi, Flavia, additional, Pontecorvi, Valerio, additional, Ponziani, Francesca, additional, Popolla, Valentina, additional, Porceddu, Enrica, additional, Porfidia, Angelo, additional, Porro, Lucia Maria, additional, Potenza, Annalisa, additional, Pozzana, Francesca, additional, Privitera, Giuseppe, additional, Pugliese, Daniela, additional, Pulcini, Gabriele, additional, Racco, Simona, additional, Raffaelli, Francesca, additional, Ramunno, Vittoria, additional, Rapaccini, Gian Ludovico, additional, Richeldi, Luca, additional, Rinninella, Emanuele, additional, Rocchi, Sara, additional, Romanò, Bruno, additional, Romano, Stefano, additional, Rosa, Federico, additional, Rossi, Laura, additional, Rossi, Raimondo, additional, Rossini, Enrica, additional, Rota, Elisabetta, additional, Rovedi, Fabiana, additional, Rubino, Carlotta, additional, Rumi, Gabriele, additional, Russo, Andrea, additional, Sabia, Luca, additional, Salerno, Andrea, additional, Salini, Sara, additional, Salvatore, Lucia, additional, Samori, Dehara, additional, Sandroni, Claudio, additional, Sanguinetti, Maurizio, additional, Santarelli, Luca, additional, Santini, Paolo, additional, Santolamazza, Danilo, additional, Santoliquido, Angelo, additional, Santopaolo, Francesco, additional, Santoro, Michele Cosimo, additional, Sardeo, Francesco, additional, Sarnari, Caterina, additional, Saviano, Luisa, additional, Scaldaferri, Franco, additional, Scarascia, Roberta, additional, Schepis, Tommaso, additional, Schiavello, Francesca, additional, Scoppettuolo, Giancarlo, additional, Sedda, Davide, additional, Sessa, Flaminio, additional, Sestito, Luisa, additional, Settanni, Carlo, additional, Siciliano, Matteo, additional, Siciliano, Valentina, additional, Sicuranza, Rossella, additional, Simeoni, Benedetta, additional, Simonetti, Jacopo, additional, Smargiassi, Andrea, additional, Soave, Paolo Maurizio, additional, Sonnino, Chiara, additional, Staiti, Domenico, additional, Stella, Claudia, additional, Stella, Leonardo, additional, Stival, Eleonora, additional, Taddei, Eleonora, additional, Talerico, Rossella, additional, Tamburello, Elio, additional, Tamburrini, Enrica, additional, Tanzarella, Eloisa Sofia, additional, Tarascio, Elena, additional, Tarli, Claudia, additional, Tersali, Alessandra, additional, Tilli, Pietro, additional, Timpano, Jacopo, additional, Torelli, Enrico, additional, Torrini, Flavia, additional, Tosato, Matteo, additional, Tosoni, Alberto, additional, Tricoli, Luca, additional, Tritto, Marcello, additional, Tumbarello, Mario, additional, Tummolo, Anita Maria, additional, Vallecoccia, Maria Sole, additional, Valletta, Federico, additional, Varone, Francesco, additional, Vassalli, Francesco, additional, Ventura, Giulio, additional, Verardi, Lucrezia, additional, Vetrone, Lorenzo, additional, Vetrugno, Giuseppe, additional, Visconti, Elena, additional, Visconti, Felicia, additional, Viviani, Andrea, additional, Zaccaria, Raffaella, additional, Zaccone, Carmelina, additional, Zelano, Lorenzo, additional, Dal Verme, Lorenzo Zileri, additional, and Zuccalà, Giuseppe, additional
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- 2020
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44. Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE)
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Ciccullo, Arturo, primary, Baldin, Gianmaria, additional, Capetti, Amedeo, additional, Borghi, Vanni, additional, Sterrantino, Gaetana, additional, Latini, Alessandra, additional, Madeddu, Giordano, additional, Celani, Luigi, additional, Vignale, Francesca, additional, Rossetti, Barbara, additional, Dusina, Alex, additional, Cossu, Maria Vittoria, additional, Restelli, Sibilla, additional, Gennari, William, additional, Lagi, Filippo, additional, Giacomelli, Andrea, additional, Colafigli, Manuela, additional, Brescini, Lucia, additional, Borghetti, Alberto, additional, Mussini, Cristina, additional, Rusconi, Stefano, additional, and Di Giambenedetto, Simona, additional
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- 2019
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45. Cohort profile: The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE)
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Ciccullo, Arturo, Baldin, G., Capetti, A., Borghi, V., Sterrantino, G., Latini, A., Madeddu, G., Celani, L., Vignale, F., Rossetti, Barbara, Dusina, Alex, Cossu, M. V., Restelli, S., Gennari, W., Lagi, F., Giacomelli, A., Colafigli, M., Brescini, L., Borghetti, A., Mussini, C., Rusconi, S., Di Giambenedetto, Simona, Ciccullo A., Rossetti B., Dusina A., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Ciccullo, Arturo, Baldin, G., Capetti, A., Borghi, V., Sterrantino, G., Latini, A., Madeddu, G., Celani, L., Vignale, F., Rossetti, Barbara, Dusina, Alex, Cossu, M. V., Restelli, S., Gennari, W., Lagi, F., Giacomelli, A., Colafigli, M., Brescini, L., Borghetti, A., Mussini, C., Rusconi, S., Di Giambenedetto, Simona, Ciccullo A., Rossetti B., Dusina A., and Di Giambenedetto S. (ORCID:0000-0001-6990-5076)
- Abstract
Purpose The Observational cohort for the study of DOlutegravir in Antiretroviral Combination REgimens (ODOACRE) cohort was established in Italy in 2016 to evaluate the overall efficacy and tolerability of dolutegravir (DTG)-based antiretroviral (ARV) regimens in clinical practice. Participants The ODOACRE cohort enrols all adult HIV-1-infected patients, both treatment-naïve and treatment-experienced, starting a DTG-based ARV regimen, in 11 clinical centres in Italy from 2014. Findings to date In recent years, various works by the ODOACRE cohort have been produced, demonstrating the high efficacy and tolerability of DTG-based ARV regimens in clinical practice, both in ART-naïve (in the setting of acute HIV-1 infection and late presenters patient) and experienced patients. We confirmed the virological efficacy of DTG-based regimens and we evaluated predictors of virological failure. We investigated cause of discontinuation and evaluated tolerability and metabolic profile of the regimens. Within these investigations, we explored particularly the use of DTG in simplification in two-drug regimen with either rilpivirine or lamivudine. We also compared DTG-based regimens with other integrase inhibitors in clinical practice. Future plans To continue to study long-term efficacy and tolerability of DTG-based regimens is the purpose of the ODOACRE cohort.
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- 2019
46. Efficacy and safety of raltegravir in switch strategies in virologically suppressed patients: long-term data from clinical practice
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Emiliozzi, Arianna, Ciccullo, Arturo, Baldin, Gianmaria, Moschese, Davide, Dusina, Alex, Borghetti, Alberto, Di Giambenedetto, Simona, Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Emiliozzi, Arianna, Ciccullo, Arturo, Baldin, Gianmaria, Moschese, Davide, Dusina, Alex, Borghetti, Alberto, Di Giambenedetto, Simona, and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Sir, We appreciated the recently published work by d’Arminio Monforte et al.1 on the durability of integrase strand transfer inhibitors (INSTIs) in a large cohort of treatment-naive HIV-positive patients. Indeed, INSTI-based regimens have become the first choice for initial HIV therapy, but they are also very popular as part of three-drug or two-drug switching strategies. Eleven years have passed since the first-generation INSTI, raltegravir, was introduced. Despite the availability of the new INSTIs, such as dolutegravir (with higher genetic barrier) and elvitegravir (available as a single tablet regimen), raltegravir still plays an important role in combination ART (cART).2 The major advantages of using raltegravir are the virtual absence of potential interactions with concomitant drugs and its high bioavailability irrespective of food intake. To investigate the safety and efficacy of raltegravir in the setting of cART optimization, we performed a retrospective study enrolling HIV-1-infected, virologically suppressed (defined as HIV-RNA <50 copies/mL) patients switching to a raltegravir-containing dual or triple therapy. The study period ranged from September 2008 to May 2017. We evaluated the percentage of patients free from treatment discontinuation (TD; discontinuation of raltegravir for any reason regardless of whether the remaining antiretroviral drugs used in the combination had been stopped or not) and from virological failure (VF; defined as two consecutive counts of HIV-RNA ≥50 copies/mL or one of ≥1000 copies/mL) at weeks 48, 96 and 144. Kaplan–Meier curves and Cox regression models were performed to estimate the time to event and the predictors of TD and VF. Data analysed in the present study were selected from an internal observational database, which collects the main clinical and demographic characteristics of every patient who gave informed consent to personal data record since the time of HIV diagnosis. The creation of the database was approved
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- 2019
47. Efficacy and durability of two‐ vs. three‐drug integrase inhibitor‐based regimens in virologically suppressed HIV‐infected patients: Data from real‐life ODOACRE cohort.
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Fabbiani, Massimiliano, Rossetti, Barbara, Ciccullo, Arturo, Oreni, Letizia, Lagi, Filippo, Celani, Luigi, Colafigli, Manuela, De Vito, Andrea, Mazzitelli, Maria, Dusina, Alex, Durante, Miriam, Montagnani, Francesca, Rusconi, Stefano, Capetti, Amedeo, Sterrantino, Gaetana, D'Ettorre, Gabriella, Di Giambenedetto, Simona, Zanelli, Giacomo, Baldin, Gianmaria, and Borghetti, Alberto
- Subjects
HIV infections ,HIV-positive persons ,HIV integrase inhibitors ,COMBINATION drug therapy ,CLINICAL trials ,RNA ,TREATMENT effectiveness ,COMPARATIVE studies ,SURVIVAL analysis (Biometry) ,DESCRIPTIVE statistics - Abstract
Objectives: The aim of the present study was to compare the efficacy and durability of treatment switch to two‐drug (2DR) vs. three‐drug (3DR) integrase inhibitor (InSTI)‐based regimens in a real‐life setting. Methods: Within the ODOACRE cohort, we selected adult patients with HIV RNA < 50 copies/mL switching to an InSTI‐based 2DR or 3DR. Survival analyses were performed to estimate the probability of virological failure (VF, defined as one HIV RNA > 1000 copies/mL or two consecutive HIV RNA > 50 copies/mL) and treatment discontinuation (TD, defined as any modification, intensification or interruption of the regimen), and to evaluate their predictors. Results: Overall, 1666 patients were included, of whom 1334 (80%) were treated with a 3DR (19.9%, 25.0% and 55.1% elvitegravir‐, raltegravir‐ and dolutegravir‐based, respectively) and 332 (20%) with a 2DR (79.2% dolutegravir + lamivudine and 20.8% dolutegravir + rilpivirine). Over a median (interquartile range) follow‐up of 100 (52–150) weeks, 52 (3.1%) patients experienced VF with an incidence of 1.5/100 person‐year of follow‐up (PYFU). The estimated 96‐week probability of VF was similar for the 2DR and 3DR groups (2.3% vs. 2.8%, P = 0.53), but it was higher for elvitegravir (4.9%) and raltegravir (5.0%) than for dolutegravir (1.5%) (P = 0.04). Four hundred (24%) patients discontinued their InSTI‐based regimen, with an incidence of 11.3/100 PYFU. At 96 weeks, 3DRs showed a higher probability of TD for any reason (20.6% vs. 11.2%, P < 0.001) and TD for toxicity (9.0% vs. 6.6%, P = 0.02) when compared with 2DRs. A higher risk of TD for central nervous system toxicity was observed for dolutegravir than for elvitegravir and raltegravir (4.0% vs. 2.5% vs. 0.6%, P = 0.005). Conclusions: In virologically suppressed HIV‐infected patients, 2DRs showed an efficacy similar to 3DRs but with better tolerability. [ABSTRACT FROM AUTHOR]
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- 2021
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48. Efficacy and safety of raltegravir in switch strategies in virologically suppressed patients: long-term data from clinical practice
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Emiliozzi, Arianna, primary, Ciccullo, Arturo, additional, Baldin, Gianmaria, additional, Moschese, Davide, additional, Dusina, Alex, additional, Borghetti, Alberto, additional, and Di Giambenedetto, Simona, additional
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- 2019
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49. Changes in bone mineral density in HIV-positive, virologically suppressed patients switching to lamivudine/dolutegravir dual therapy: preliminary results from clinical practice
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Ciccullo, Arturo, D'Avino, Alessandro, Lassandro, Anna Pia, Baldin, Gianmaria, Borghetti, Alberto, Dusina, Alex, Emiliozzi, Arianna, Gagliardini, Roberta, Moschese, Davide, Belmonti, Simone, Lombardi, Francesca, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Ciccullo, Arturo, D'Avino, Alessandro, Lassandro, Anna Pia, Baldin, Gianmaria, Borghetti, Alberto, Dusina, Alex, Emiliozzi, Arianna, Gagliardini, Roberta, Moschese, Davide, Belmonti, Simone, Lombardi, Francesca, Di Giambenedetto, Simona, Lombardi, Francesca (ORCID:0000-0001-5757-8346), and Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076)
- Abstract
Bone toxicity is a well-known side effect of several antiviral agents. In a cohort of virologically suppressed HIV-infected patients, we investigated the effects of a lamivudine/dolutegravir dual therapy on bone mineral density (BMD). We observed a significant improvement in lumbar spine BMD as well as T-score after 12 months of observation with concomitant bisphosphonate therapy independently predicting a greater improvement. These preliminary data show a favorable effect of this 2-drug regimen on bone health.
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- 2018
50. EFFICACY OF 3TC+DTG VS 3-DRUG REGIMENS IN VIROLOGICALLYSUPPRESSED PLWH.
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Borghetti, Alberto, Ciccullo, Arturo, Lombardi, Francesca, Passerotto, Rosanna, Lamanna, Francesco, Farinacci, Damiano, Dusina, Alex, Baldin, Gianmaria, Zazzi, Maurizio, and Di Giambenedetto, Simona
- Published
- 2023
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