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2. Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications.

Author

Cinici, Bilal, Yaba, Sule, Kurt, Mustafa, Yalcin, Huseyin C., Duta, Liviu, and Gunduz, Oguzhan

Subjects
ENGINEERING design, TISSUE scaffolds, TISSUE engineering, REGENERATIVE medicine, THREE-dimensional printing, SELECTIVE laser sintering, STEREOLITHOGRAPHY
Abstract

The aim of this study is to provide an overview of the current state-of-the-art in the fabrication of bioceramic scaffolds for bone tissue engineering, with an emphasis on the use of three-dimensional (3D) technologies coupled with generative design principles. The field of modern medicine has witnessed remarkable advancements and continuous innovation in recent decades, driven by a relentless desire to improve patient outcomes and quality of life. Central to this progress is the field of tissue engineering, which holds immense promise for regenerative medicine applications. Scaffolds are integral to tissue engineering and serve as 3D frameworks that support cell attachment, proliferation, and differentiation. A wide array of materials has been explored for the fabrication of scaffolds, including bioceramics (i.e., hydroxyapatite, beta-tricalcium phosphate, bioglasses) and bioceramic–polymer composites, each offering unique properties and functionalities tailored to specific applications. Several fabrication methods, such as thermal-induced phase separation, electrospinning, freeze-drying, gas foaming, particle leaching/solvent casting, fused deposition modeling, 3D printing, stereolithography and selective laser sintering, will be introduced and thoroughly analyzed and discussed from the point of view of their unique characteristics, which have proven invaluable for obtaining bioceramic scaffolds. Moreover, by highlighting the important role of generative design in scaffold optimization, this review seeks to pave the way for the development of innovative strategies and personalized solutions to address significant gaps in the current literature, mainly related to complex bone defects in bone tissue engineering. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Multifunctional Polymeric Biodegradable and Biocompatible Coatings Based on Silver Nanoparticles: A Comparative In Vitro Study on Their Cytotoxicity towards Cancer and Normal Cell Lines of Cytostatic Drugs versus Essential-Oil-Loaded Nanoparticles and on Their Antimicrobial and Antibiofilm Activities

Author

Puiu, Rebecca Alexandra, primary, Bîrcă, Alexandra Cătălina, additional, Grumezescu, Valentina, additional, Duta, Liviu, additional, Oprea, Ovidiu Cristian, additional, Holban, Alina Maria, additional, Hudiță, Ariana, additional, Gălățeanu, Bianca, additional, Balaure, Paul Cătălin, additional, Grumezescu, Alexandru Mihai, additional, and Andronescu, Ecaterina, additional

Published
2023
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11. Hydroxyapatite Thin Films of Marine Origin as Sustainable Candidates for Dental Implants

Author

Dorcioman, Gabriela, primary, Grumezescu, Valentina, additional, Stan, George E., additional, Chifiriuc, Mariana Carmen, additional, Gradisteanu, Gratiela Pircalabioru, additional, Miculescu, Florin, additional, Matei, Elena, additional, Popescu-Pelin, Gianina, additional, Zgura, Irina, additional, Craciun, Valentin, additional, Oktar, Faik Nüzhet, additional, and Duta, Liviu, additional

Published
2023
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13. Synthetic and Biological-Derived Hydroxyapatite Implant Coatings.

Author

Duta, Liviu and Oktar, Faik Nüzhet

Subjects
HYDROXYAPATITE coating, PLASMA sprayed coatings, METAL coating, PULSED laser deposition, COMPOSITE coating, BIOMATERIALS
Abstract

This document discusses the use of hydroxyapatite (HA) coatings for orthopedic and dental implants. HA is a bioceramic material that enhances fixation and osseointegration at the implant-tissue interface. The document highlights the advantages of using biodegradable implants, such as eliminating the need for a secondary surgical intervention. It also explores the use of synthetic and biological-derived HA, with the latter showing enhanced mechanical performance and bioactivity. Various techniques for coating implants with HA are discussed, including plasma spray, pulsed laser deposition, and biomimetic coating. The document concludes by emphasizing the focus on the synthesis and characterization of HA-based coatings for applications in bone repair, tissue engineering, and dental implants. [Extracted from the article]

Published
2024
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20. Fish Bone Derived Bi-Phasic Calcium Phosphate Coatings Fabricated by Pulsed Laser Deposition for Biomedical Applications

Author

Popescu-Pelin, Gianina, primary, Ristoscu, Carmen, additional, Duta, Liviu, additional, Pasuk, Iuliana, additional, Stan, George E., additional, Stan, Miruna Silvia, additional, Popa, Marcela, additional, Chifiriuc, Mariana C., additional, Hapenciuc, Claudiu, additional, Oktar, Faik N., additional, Nicarel, Anca, additional, and Mihailescu, Ion N., additional

Published
2020
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22. Antimicrobial and Cytocompatible Bovine Hydroxyapatite-Alumina-Zeolite Composite Coatings Synthesized by Pulsed Laser Deposition from Low-Cost Sustainable Natural Resources

Author

Popescu-Pelin, Gianina, primary, Ristoscu, Carmen, additional, Duta, Liviu, additional, Stan, George E., additional, Pasuk, Iuliana, additional, Tite, Teddy, additional, Stan, Miruna Silvia, additional, Bleotu, Coralia, additional, Popa, Marcela, additional, Chifiriuc, Mariana C., additional, Oktar, Faik Nuzhet, additional, Nicarel, Anca, additional, and Mihailescu, Ion N., additional

Published
2020
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23. Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants

Author

Chioibasu, Diana, primary, Duta, Liviu, additional, Popescu-Pelin, Gianina, additional, Popa, Nicoleta, additional, Milodin, Nichita, additional, Iosub, Stefana, additional, Balescu, Liliana Marinela, additional, Catalin Galca, Aurelian, additional, Claudiu Popa, Adrian, additional, Oktar, Faik N., additional, Stan, George E., additional, and Popescu, Andrei C., additional

Published
2019
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30. Preface – ICPEPA-10

Author

Mihailescu, Ion N., primary, Duta, Liviu, additional, Abrudan, Ioan Vasile, additional, and Floroian, Laura, additional

Published
2017
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31. Fabrication of antimicrobial silver-doped carbon structures by combinatorial pulsed laser deposition

Author

Mihailescu, Ion N., primary, Bociaga, Dorota, additional, Socol, Gabriel, additional, Stan, George E., additional, Chifiriuc, Mariana-Carmen, additional, Bleotu, Coralia, additional, Husanu, Marius A., additional, Popescu-Pelin, Gianina, additional, Duta, Liviu, additional, Luculescu, Catalin R., additional, Negut, Irina, additional, Hapenciuc, Claudiu, additional, Besleaga, Cristina, additional, Zgura, Irina, additional, and Miculescu, Florin, additional

Published
2016
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33. The Role of Ambient Gas and Pressure on the Structuring of Hard Diamond-Like Carbon Films Synthesized by Pulsed Laser Deposition

Author

Popescu, Andrei, primary, Stan, George, additional, Duta, Liviu, additional, Nita, Cristina, additional, Popescu, Camelia, additional, Surdu, Vasile-Adrian, additional, Husanu, Marius-Adrian, additional, Bita, Bogdan, additional, Ghisleni, Rudy, additional, Himcinschi, Cameliu, additional, and Craciun, Valentin, additional

Published
2015
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35. Measuring Nanolayer Profiles of Various Materials by Evanescent Light Technique

Author

Mirchin, Nina, primary, Apter, Boris, additional, Lapsker, Igor, additional, Fogel, V., additional, Gorodetsky, Uri, additional, Popescu, Simona A., additional, Peled, Aaron, additional, Popescu-Pelin, Gianina, additional, Dorcioman, Gabriela, additional, Duta, Liviu, additional, Popescu, Andrei, additional, and Mihailescu, Ion N., additional

Published
2012
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37. In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits

Author

Johny Neamtu, Oana A. Zureigat, Andrei C. Popescu, Faik N. Oktar, Diana Chioibasu, Liviu Duta, Razvan Melinte, Gianina Popescu-Pelin, Duta, Liviu, Neamtu, Johny, Melinte, Razvan P., Zureigat, Oana A., Popescu-Pelin, Gianina, Chioibasu, Diana, Oktar, Faik N., and Popescu, Andrei C.

Subjects
Fabrication, Materials science, Scanning electron microscope, chemistry.chemical_element, PORCINE BONE, 02 engineering and technology, METALLIC IMPLANTS, 010402 general chemistry, 01 natural sciences, food industrial by-products, Pulsed laser deposition, THIN-FILMS, In vivo, Ultimate tensile strength, Materials Chemistry, biological-derived hydroxyapatite coatings, DEPOSITION, pulsed laser deposition, in vivo extraction force, GENE-EXPRESSION, Extraction (chemistry), Titanium alloy, Surfaces and Interfaces, 3D printing, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, DIFFERENTIATION, chemistry, lcsh:TA1-2040, Lithium, MAGNESIUM-ENRICHED HYDROXYAPATITE, 0210 nano-technology, lcsh:Engineering (General). Civil engineering (General), lithium doping, STEM-CELLS, Biomedical engineering
Abstract

We report on biological-derived hydroxyapatite (HA, of animal bone origin) doped with lithium carbonate (Li-C) and phosphate (Li-P) coatings synthesized by pulsed laser deposition (PLD) onto Ti6Al4V implants, fabricated by the additive manufacturing (AM) technique. After being previously validated by in vitro cytotoxicity tests, the Li-C and Li-P coatings synthesized onto 3D Ti implants were preliminarily investigated in vivo, by insertion into rabbits&rsquo, femoral condyles. The in vivo experimental model for testing the extraction force of 3D metallic implants was used for this study. After four and nine weeks of implantation, all structures were mechanically removed from bones, by tensile pull-out tests, and coatings&rsquo, surfaces were investigated by scanning electron microscopy. The inferred values of the extraction force corresponding to functionalized 3D implants were compared with controls. The obtained results demonstrated significant and highly significant improvement of functionalized implants&rsquo, attachment to bone (p-values &le, 0.05 and &le, 0.00001), with respect to controls. The correct placement and a good integration of all 3D-printed Ti implants into the surrounding bone was demonstrated by performing computed tomography scans. This is the first report in the dedicated literature on the in vivo assessment of Li-C and Li-P coatings synthesized by PLD onto Ti implants fabricated by the AM technique. Their improved mechanical characteristics, along with a low fabrication cost from natural, sustainable resources, should recommend lithium-doped biological-derived materials as viable substitutes of synthetic HA for the fabrication of a new generation of metallic implant coatings.

Published
2020

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