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Prostate cancer (PCa) is a major health problem and one of the main causes of cancer mortality in men [1]. In patients with PCa, bone metastases manifest in 100% of patients when the PSA level exceeds 100 ng/ml causing pains and posing a risk for pathological fractures [2]. We report a case of a 70-year-old male with PCa and pathological fractures of the vertebrae, in whom we observed long-term regression and an 8-year-survival while undergoing continuous therapy. As far as we know, this is the first reported case in literature with such an unexpected outcome. [ABSTRACT FROM AUTHOR]

Introduction. Infections with genital types of human papillomavirus (HPV) occur in all populations worldwide. Although HPV infection not always leads to penile cancer development, extended diagnostic procedures should be definitely carried out to detect the viruses, and after finding the infection, sparing treatment, which is fundamental for penile cancer prophylaxis, should be given. Cancer development due to symptomatic or subclinical infection, requires many years of chronic inflammation and various additional factors. Smegma remaining under the foreskin and phimosis are the examples of favorable conditions for cancer development in males. Own studies and ways of treatment of males with phimosis and foreskin lesions associated with HPV infection are presented. Material and method. Own studies involved 56 males treated surgically by circumcision for phimosis and foreskin lesions (extended circumcision, i.e. radical posthetomy with total excision of the inner lamina) and then widely diagnosed including virological investigations. Results. HPV DNA was detected in 90% of the treated subjects. Seven patients required extensive operation for confirmed penile cancer, and the remaining 49 patients required organ-sparing circumcision. Conclusions. We think it is necessary to carry out virological tests and cooperate with gynecologists in the diagnosis and treatment, to make possible, through early detection of HPV infection in sexual partners, treatment of male patients limited to organ-sparing operation. [ABSTRACT FROM AUTHOR]