Search

Your search keyword '"Dutta, Sisir K."' showing total 24 results
Start Over Author "Dutta, Sisir K."
24 results on '"Dutta, Sisir K."'

5. PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations

Author

Ghosh, Somiranjan, primary, Loffredo, Christopher A., additional, Mitra, Partha S., additional, Trnovec, Tomas, additional, Palkovicova Murinova, Lubica, additional, Sovcikova, Eva, additional, Hoffman, Eric P., additional, Makambi, Kepher H., additional, and Dutta, Sisir K., additional

Published
2017
Full Text
View/download PDF

7. Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development

Author

Dutta, Sisir K., primary, Mitra, Partha S., additional, Ghosh, Somiranjan, additional, Zang, Shizhu, additional, Sonneborn, Dean, additional, Hertz-Picciotto, Irva, additional, Trnovec, Tomas, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Ghimbovschi, Svetlana, additional, and Hoffman, Eric P., additional

Published
2012
Full Text
View/download PDF

8. Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: Correlations between gene expression and disease risk

Author

Mitra, Partha Sarathi, primary, Ghosh, Somiranjan, additional, Zang, Shizhu, additional, Sonneborn, Dean, additional, Hertz-Picciotto, Irva, additional, Trnovec, Tomas, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Ghimbovschi, Svetlana, additional, Hoffman, Eric P., additional, and Dutta, Sisir K., additional

Published
2012
Full Text
View/download PDF

9. VALIDATION OF SIGNATURE BIOMARKERS BY HIGH-THROUGHPUT TAQMAN® LOW DENSITY ARRAY (TLDA) IN PCB-EXPOSED SLOVAK POPULATION

Author

Ghosh, Somiranjan, primary, Mitra, Partha Sarathi, additional, Malve, Piyush, additional, Trnovec, Toma s, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Hertz-Picciotto, Irva, additional, Sonneborn, Dean, additional, Ghimbovschi, Svetlana, additional, Hoffman, Eric P., additional, and Dutta, Sisir K., additional

Published
2011
Full Text
View/download PDF

18. Handling of polychlorinated biphenyls

Author

Dutta, Sisir K.

Subjects
Polychlorinated biphenyls -- Composition -- Research, Business, High technology industry
Abstract

Polychlorinated biphenyls (PCBs) are compounds made up of a mixture of up to 209 individual chlorinated compounds called congeners. There is no natural source for PCBs. Their entrance in soil, [...]

Published
2007

19. Status of LEPRGene in PCB-exposed Population: A Quick Look

Author

Ghosh, Somiranjan, Trnovec, Tomas, Palkovicova, Lubica, Hoffman, Eric P., Washington, Kareem, and Dutta, Sisir K.

Abstract

AbstractEarlier, we have reported that Polychlorinated Biphenyls (PCBs) exposure in Slovak population has made differential gene expression that has linked to the possibilities of some diseases and disorder development in the studied population. Here we report that down-regulation of LEPR (Leptin receptor) gene in the 45-month children may have been following consequences in developing obesity later in life. A pilot high-throughput qRT-PCR [Taqman Low Density Array (TLDA)] study in a small population also corroborated the gene-expression results, and their pathways underlying the consequences of the diseases, amid further detailed large-scale population validation. The study shows the opportunity of predicting long-term effects of chemical exposures using selected genomic classifiers may reflect exposure effect and risk from environmental toxicants.

Published
2013
Full Text
View/download PDF

23. Biomarkers linking PCB exposure and obesity.

Author

Ghosh S, Murinova L, Trnovec T, Loffredo CA, Washington K, Mitra PS, and Dutta SK

Subjects
Biomarkers analysis, Environmental Exposure analysis, Humans, Obesity epidemiology, Obesity genetics, Obesity metabolism, Endocrine Disruptors toxicity, Environmental Exposure adverse effects, Environmental Pollutants toxicity, Gene Expression drug effects, Obesity chemically induced, Polychlorinated Biphenyls toxicity
Abstract

Recently the prevalence of obesity has increased dramatically across much of the world. Obesity, as a complex, multifactorial disease, and its health consequences probably result from the interplay of environmental, genetic, and behavioral factors. Several lines of evidence support the theory that obesity is programmed during early development and that environmental exposures can play a key role. We therefore hypothesize that the current epidemic might associated with the influence of chemical exposures upon genetically controlled developmental pathways, leading to metabolic disorders. Some environmental chemicals, such as PCBs and pesticide residues, are widespread in food, drinking water, soil, and they exert multiple effects including estrogenic on cellular processes; some have been shown to affect the development of obesity, insulin resistance, type 2 diabetes, and metabolic syndrome. To bring these lines of evidence together and address an important health problem, this narrative review has been primarily designed to address PCBs exposures that have linked with human disease, obesity in particular, and to assess the effects of PCBs on gene expression in a highlyexposed population. The results strongly suggest that further research into the specific mechanisms of PCBs-associated diseases is warranted.

Published
2014
Full Text
View/download PDF

24. Congener specific polychlorinated biphenyl metabolism by human intestinal microbe Clostridium species: Comparison with human liver cell line-HepG2.

Author

De S, Ghosh S, and Dutta SK

Abstract

Polychlorobiphenyls (PCBs), which adversely affect human fetal and infant development, are endocrine disrupter and cause neurological disorders. They may also be carcinogenic. It is not known whether these effects are due to whole PCBs or to its metabolites, produced by the human gastrointestinal system primarily the liver and/or by intestinal microbes such as Clostridium sp. The available data show that Clostridium perfringens , the most prominent species of Clostridium occurs in the human gut. C. beijerinckii i s a special type of Clostridium present in the gut of autistic children with late onset autism. Since mixed cultures are better PCB metabolizers than single cultures, mixed cultures of Clostridium were used in this work. The first step in PCB degradation is the removal of the chlorine atoms and then the breaking open of the phenyl ring leading to the final degradation product: CO 2 . In this study, GC-MS analyses were done to examine the effect of Clostridium sp. on PCB-153 and PCB-77 and the metabolites obtained with Clostridium sp. therein. In this paper, we report that the unlike human liver cells which cannot produce any PCB metabolites. Mixed Clostridium spp. can degrade these PCBs. Clostridium spp. and were able to dechlorinate PCB 153 (hexachlorobiphenyl) to pentachlorobiphenyl and PCB 77 (tetrachlorobiphenyl) to trichlorobiphenyl. Despite considerable absorption of PCB 153 (40%) and PCB 77 (50%) in 30 minutes and 1.5 hours respectively by human liver (HepG2) cells, they can not dechlorinate PCBs. It has been observed that slight differences in chemical structures of PCBs such as coplanar (PCB-77) vs. non-coplanar (PCB-153) has significant metabolic effects.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results