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Hemodynamics and phase structure of the cardiac cycle have been studied, using a technical complex "KO phi OOC", on 12 anesthesiologists volunteers during various stages of Xe anesthesia (70:30). During 30 min anesthesia Xe formed conditions for normalization of hemodynamic changes caused by emotional stress, had no depressive effect on the myocardium, failed to affect considerably vascular tone and myocardial phase structure. Due to its narcotic effect Xe changed variability of the cardiac rhythm.

Clinical pattern of monoanesthesia with Xe:O2 (70:30) has been studied in 12 anesthesiologists volunteers in comparison with their subjective sensations. Four clinical stages of anesthesia have been identified: paresthesia and hypoalgesia, euphoria and psychomotor activity, analgesia and partial amnesia, anesthesia (analgesia and amnesia). Induction anesthesia took 5 to 6 min, anesthesia discontinuation was easy and prompt without any adverse events. In healthy men it was impossible to achieve complete amnesia with Xe:O2 (60:40). Subjective sensations from the anesthesia were pleasant. Xenone is the best alternative to N2O2.

The data of 114 examinations of 38 patients with respiratory failure of different genesis have been presented. The method used was that of averaging the ECG signal with analysis of late ventricular potentials and parameters of spectral mapping, as well as analysis of the R-R intervals. The patients were examined initially, 30-45 min after intravenous injection of 1 mg dalargin and 16-20 hours later. The results have shown that there were differences in the changes of a number of basic characteristics of the QRS complex spectrum. In 18 cases (21%) signs of late potentials have been recorded, 14 of them (78%) in the group with decreased total spectral density. A shift of extremums by the beginning of QRS was observed. Statistical and spectral characteristics of the R-R intervals changed in one direction. It has been shown that dalargin has a complex effect on electrophysiological myocardial properties. The use of the method of ECG signal averaging and its different modifications broadens considerably the quality of evaluation of the drug effect in the heart. The technique of spectral-time mapping simplifies the diagnosis of late potentials and elucidates their inner structure.