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We catalog the 443 bright supernovae discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN) in $2018-2020$ along with the 519 supernovae recovered by ASAS-SN and 516 additional $m_{peak}\leq18$ mag supernovae missed by ASAS-SN. Our statistical analysis focuses primarily on the 984 supernovae discovered or recovered in ASAS-SN $g$-band observations. The complete sample of 2427 ASAS-SN supernovae includes earlier $V$-band samples and unrecovered supernovae. For each supernova, we identify the host galaxy, its UV to mid-IR photometry, and the offset of the supernova from the center of the host. Updated light curves, redshifts, classifications, and host galaxy identifications supersede earlier results. With the increase of the limiting magnitude to $g\leq18$ mag, the ASAS-SN sample is roughly complete up to $m_{peak}=16.7$ mag and is $90\%$ complete for $m_{peak}\leq17.0$ mag. This is an increase from the $V$-band sample where it was roughly complete up to $m_{peak}=16.2$ mag and $70\%$ complete for $m_{peak}\leq17.0$ mag., Comment: 14 pages, 7 figures, 4 tables. Updated to reflect changes made in the published version. Tables containing the catalog data presented in this submission are included in machine-readable format as ancillary files

Context. The quadruple lensed system WGD2038-4008 (zs = 0.777 ± 0.001) has recently been discovered with the help of new techniques and observations. Black hole masses have been estimated for lensed quasars, but they have mostly been calculated for one broad emission line of one image. However, the images could be affected by microlensing, which changes the results. Aims. We present black hole mass (MBH) estimations for images A and B of WGD2038-4008 using the three most prominent broad emission lines (Hα, Hβ, and Mg II) obtained in one single-epoch spectra. This is the first time the mass has been estimated in a lensed quasar in two images, allowing us to disentangle the effects of microlensing. The high S/N of our spectra allows us to get reliable results that can be compared with the existing data in the literature. Methods. We used the X-shooter instrument mounted on the Very Large Telescope at Paranal Observatory to observe this system, taking advantage of its wide spectral range (UVB, VIS, and NIR). The sky emission correction was performed using principal component analysis as the nodding was small compared to the image separation. We compared the lines profiles to identify the microlensing in the broad-line region and corrected each spectra by the image magification. Using the flux ratio of the continuum to the core of the emission lines, we analyzed whether microlensing was present in the continuum source. Results. We obtained MBH using the single-epoch method with the Hα and Hβ emission lines from the monochromatic luminosity and the velocity width. The luminosity at 3000 Å was obtained using the spectral energy distribution of image A, while the luminosity at 5100 Å was estimated directly from the spectra. The average MBH between the images obtained was log10(MBH/M⊙) = 8.27 ± 1.05, 8.25 ± 0.32, and 8.59 ± 0.35 for Mg II, Hβ, and Hα, respectively. We find Eddington ratios similar to those measured in the literature for unlensed low-luminosity quasars. Microlensing of −0.16 ± 0.06 mag in the continuum was found, but the induced error in the MBH is minor compared to that associated with the macromodel magnification. We also obtained the accretion disk size using the MBH for the three emission lines, obtaining an average value of log10(rs/cm)=15.3 ± 0.63, which is in agreement with theoretical estimates.

Introduction/Background* Platinum in combination with paclitaxel (P) and bevacizumab is the standard of care in first-line recurrent/advanced cervical cancer (Tewari, NEJM 2020). Nintedanib is an oral tyrosine kinase inhibitor targeting, among others, vascular endothelial growth factor receptor. Methodology Double-blind phase II randomised study in patients with first-line recurrent or primary advanced (FIGO stage IVB) cervical cancer. Patients received carboplatin AUC 5-6 and paclitaxel 175mg/m2 q 3 weeks with oral nintedanib 200 mg BID/placebo. Stratification factor was primary advanced versus recurrent disease. The primary endpoint was progression-free survival (PFS) at 1,5 years with at least 87 events and α=0.15, β=80%, one sided, in favor of the nintedanib (N) versus control (C) arm. The study (NCT02009579) was performed according to the ENGOT model A. Result(s)* 120 patients (62 N, 58 C) were randomised between March 2014 and October 2018. Median follow-up was 35 months. Baseline characteristics were similar in both groups (total population: squamous cell carcinoma 62%, prior radiotherapy 64%, primary advanced 25%, recurrent 75%). The primary endpoint was met with a PFS at 1.5 years of 15.1% versus 12.8% in favour of the nintedanib arm (p = 0.057). Median overall survival (OS) was 21.7 and 16.4 months for N and C, respectively. Subgroup analysis did not demonstrate a difference in PFS in the primary advanced setting, but in the recurrent setting the 1 year PFS was 22.8% and 14.9% for N and C, respectively. Confirmed RECIST response rate was 48% for N and 39% for C. No new adverse events were noted for N. However N was associated with numerically more serious adverse events for anemia and febrile neutropenia. Discontinuation of chemotherapy was similar in both groups. N was discontinued in 3% versus placebo in 1.6% of the patients. Dose reduction of N was necessary in 53% of the patients. Conclusion* The study met its primary endpoint with a prolonged PFS in the N arm. No new safety signals were observed.

Many of the patients undergoing interventional procedures have daily regimens of medications including analgesics, muscle relaxants, and other drugs that can have significant additive/synergistic effects during the perioperative period. Further, many patients also present with comorbid states, including obesity, cardiovascular, and pulmonary disease. Consequently, in the perioperative period, a significant number of patients have suffered permanent neurologic injury, hypoxic brain injury, and even death as a result of over sedation, hypoventilation, and spinal cord injury. In addition, physicians are concerned about aspiration, subsequent complications, and as a result, they ask patients to fast for several hours prior to the procedures. Based on extensive literature and consensus, a minimum fasting period is established as 2 hours before a procedure for clear liquids and 4 hours before procedure for light meals, rather than having all patients fast for 8 hours or even fasting beginning at midnight the night before the procedure. Gastrointestinal stimulants, gastric acid secretion blockers, and antacids may be used, even though not routinely recommended. Due to the nature of chronic pain and anxiety, many patients undergoing interventional techniques may require mild to moderate sedation. Deep sedation and/or general anesthesia for most interventional procedures is considered as unsafe, since the patient cannot communicate acute changes in symptoms, thus, resulting in morbidity and mortality, as well as creating compliance issues. We are adapting the published standards of the American Society of Anesthesiologists for monitoring patients under sedation, regardless of the location of the procedure, either office-based, in a surgery center, or a hospital outpatient department. These standards include monitoring of blood pressure, cardiac rhythm, temperature, pulse oximetry, and continuous quantitative end tidal CO2 monitoring. Sedation must be provided either by qualified anesthesia or non-anesthesia providers, with appropriate understanding of the medications, drug interactions, and resuscitative protocols. Key words: Guidelines, sedation, fasting status, monitoring, neurological complications

Lu, J., et al., We present photometric and spectroscopic observations of the 03fg-like Type Ia supernova (SN Ia) ASASSN-15hy from the ultraviolet (UV) to the near-infrared (NIR). ASASSN-15hy shares many of the hallmark characteristics of 03fg-like SNe Ia, previously referred to as "super-Chandrasekhar"SNe Ia. It is bright in the UV and NIR, lacks a clear i-band secondary maximum, shows a strong and persistent C ii feature, and has a low Si ii λ6355 velocity. However, some of its properties are also extreme among the subgroup. ASASSN-15hy is underluminous (M B,peak = 19.14-0.16+0.11 mag), red ((B-V) {B\max }=0.18-0.03+0.01 mag), yet slowly declining (Δm 15(B) = 0.72 ± 0.04 mag). It has the most delayed onset of the i-band maximum of any 03fg-like SN. ASASSN-15hy lacks the prominent H-band break emission feature that is typically present during the first month past maximum in normal SNe Ia. Such events may be a potential problem for high-redshift SN Ia cosmology. ASASSN-15hy may be explained in the context of an explosion of a degenerate core inside a nondegenerate envelope. The explosion impacting the nondegenerate envelope with a large mass provides additional luminosity and low ejecta velocities. An initial deflagration burning phase is critical in reproducing the low 56Ni mass and luminosity, while the large core mass is essential in providing the large diffusion timescales required to produce the broad light curves. The model consists of a rapidly rotating 1.47 M o˙ degenerate core and a 0.8 M o˙ nondegenerate envelope. This "deflagration core-degenerate"scenario may result from the merger between a white dwarf and the degenerate core of an asymptotic giant branch star., The CSP-II has been supported by NSF grants AST-1008343, AST1613426, AST-1613455, AST-1613472, and the Danish Agency for Science and Technology and Innovation through a Sapere Aude Level 2 grant (PI: M.S.) C.A. is supported by the NSF grant AST #1908952. J.L., S.K., M.S., and E.Y.H acknowledge the support provided by the Florida Space Research Program. P.A.H. acknowledges the support by the National Science Foundation grant AST-1715133. L.G. acknowledges financial support from the Spanish Ministry of Science, Innovation and Universities (MICIU) under the 2019 Ramón y Cajal program RYC2019-027683 and from the Spanish MICIU project PID2020-115253GA-I00. E.B. was supported in part by NASA grant 80NSSC20K0538. M.D.S. is supported by generous grants from Villum FONDEN (13261, 28021) and by a project grant (8021-00170B) from the Independent Research Fund Denmark. Support for T.W.-S.H. was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51458.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555. H.K. was funded by the Academy of Finland projects 324504 and 328898. Support for J.L.P. is provided in part by ANID through the Fondecyt regular grant 1191038 and through the Millennium Science Initiative grant ICN12_009, awarded to The Millennium Institute of Astrophysics, MAS. Time-domain research by D.J.S. is supported by NSF grants AST-1821987, 1813466, & 1908972, and by the Heising-Simons Foundation under grant #2020-1864. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile, and is also based upon observations made with ESO Telescopes at the La Silla or Paranal Observatories under program ID(s) 191. D-0935 and 099.D-0022(A). This work has been partially supported by the Spanish grant PGC2018-095317-B-C21 within the European Funds for Regional Development (FEDER). Finally, this paper also includes observations obtained at the international Gemini Observatory (GN2015A-Q-8, GS-2015A-Q-5), a program of NSFʼs NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. on behalf of the Gemini Observatory partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea).

Davis, S., et al., We present a study of the optical and near-infrared (NIR) spectra of SN 2013ai along with its light curves. These data range from discovery until 380 days after explosion. SN 2013ai is a fast declining Type II supernova (SN II) with an unusually long rise time, 18.9 2.7 days in the V-band, and a bright V-band peak absolute magnitude of -18.7 0.06 mag. The spectra are dominated by hydrogen features in the optical and NIR. The spectral features of SN 2013ai are unique in their expansion velocities, which, when compared to large samples of SNe II, are more than 1,000 km s-1 faster at 50 days past explosion. In addition, the long rise time of the light curve more closely resembles SNe IIb rather than SNe II. If SN 2013ai is coeval with a nearby compact cluster, we infer a progenitor zero-age main-sequence mass of ∼17 M o˙. After performing light-curve modeling, we find that SN 2013ai could be the result of the explosion of a star with little hydrogen mass, a large amount of synthesized 56Ni, 0.3-0.4 M o˙, and an explosion energy of 2.5-3.0 1051 erg. The density structure and expansion velocities of SN 2013ai are similar to those of the prototypical SN IIb, SN 1993J. However, SN 2013ai shows no strong helium features in the optical, likely due to the presence of a dense core that prevents the majority of γ-rays from escaping to excite helium. Our analysis suggests that SN 2013ai could be a link between SNe II and stripped-envelope SNe., The work of the CSP-II has been generously supported by the National Science Foundation under grants AST-1008343, AST1613426, AST-1613455, and AST1613472. The CSP-II was also supported in part by the Danish Agency for Science and Technology and Innovation through a Sapere Aude Level 2 grant. M.F. is supported by a Royal Society—Science Foundation Ireland University Research Fellowship. P.H. acknowledges support by grants of the NSF AST-1008962 and NASA’s ATP1909476. L.G. was funded by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 839090. This work has been partially supported by the Spanish grant PGC2018-095317- B-C21 within the European Funds for Regional Development (FEDER). T.W.C. acknowledges the EU Funding under Marie Skłodowska-Curie grant agreement No 842471. M.S. is supported by generous grants from Villum FONDEN (13261, 28021) and by a project grant (8021-00170B) awarded by the Independent Research Fund Denmark.

Assuming a gravitational origin for the Fe III$\lambda\lambda$2039-2113 redshift and using microlensing based estimates of the size of the region emitting this feature, we obtain individual measurements of the virial factor, $f$, in 10 quasars. The average values for the Balmer lines, $\langle f_{H\beta}\rangle={\bf 0.43\pm 0.20}$ and $\langle f_{H\alpha}\rangle={\bf 0.50\pm 0.24}$, are in good agreement with the results of previous studies for objects with lines of comparable widths. In the case of Mg II, consistent results, $f_{Mg II} \sim {\bf 0.44}$, can be also obtained accepting a reasonable scaling for the size of the emitting region. The modeling of the cumulative histograms of individual measurements, $CDF(f)$, indicates a {relatively} high value for the ratio between isotropic and cylindrical motions, $a\sim {\bf 0.4}-0.7$. On the contrary, we find very large values of the virial factor associated to the Fe III$\lambda\lambda$2039-2113 blend, $f_{FeIII}=14.3\pm2.4$, which can be explained if this feature arises from a flattened nearly face-on structure, similar to the accretion disk., Comment: Accepted in ApJ

We use spectroscopic observations of the gravitationally lensed systems SDSS0924+0219(BC), Q1355-2257(AB), and SDSS1029+2623(BC) to analyze microlensing and dust extinction in the observed components. We detect chromatic microlensing effects in the continuum and microlensing in the broad emission line profiles of the systems SDSS0924+0219(BC), and Q1355-2257(AB). Using magnification maps to simulate microlensing and modeling the emitting region as a Gaussian intensity profile with size $r_s \propto \lambda ^p$, we obtain the probability density functions for a logarithmic size prior at $\lambda_{rest-frame}=3533$ {\AA}. In the case of SDSS0924+0219, we obtain: $r_s = 4^{+3}_{-2}$ $\sqrt{M/M_{\odot}}$ light-days (at $1 \sigma$), which is larger than the range of other estimates, and $p = 0.8 \pm 0.2$ (at $1 \sigma$), which is smaller than predicted by the thin disk theory, but still in agreement with previous results. In the case of Q1355-2257 we obtain (at $1 \sigma$): $r_s = 3.6^{+3.0}_{-1.6}$ $\sqrt{M/M_{\odot}}$ light-days, which is also larger than the theoretical prediction, and $p = 2.0 \pm 0.7$ that is in agreement with the theory within errors. SDSS1029+2326 spectra show evidence of extinction, probably produced by a galaxy in the vicinity of image C. Fitting an extinction curve to the data we estimate $\Delta E \sim 0.2$ in agreement with previous results. We found no evidence of microlensing for this system., Comment: 9 pages, 12 figures

Background: The intervertebral disc has been implicated as a major cause of chronic spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients, and in 16% to 53% of patients with pain in the cervical spine. Lumbar, cervical, and thoracic provocation discography, which includes disc stimulation and morphological evaluation, is often used to distinguish a painful disc from other potential sources of pain. Despite the extensive literature on point, intense debate continues about lumbar discography as a diagnostic tool. Study Design: A systematic review of the diagnostic accuracy of lumbar, cervical, and thoracic provocation and analgesic discography literature. Objective: To systematically assess and re-evaluate the diagnostic accuracy of lumbar, cervical, and thoracic discography. Methods: The available literature on discography was reviewed. A methodological quality assessment of included studies was performed using the Quality Appraisal of Reliability Studies (QAREL) checklist. Only diagnostic accuracy studies meeting at least 50% of the designated inclusion criteria were included in the analysis. To assess the level of evidence, a modified grading of qualitative evidence criteria was utilized, with grading of evidence into 5 categories from Level I to Level V incorporating evidence obtained from multiple high quality diagnostic accuracy studies for Level I and opinion or consensus of a large group of clinicians and/or scientists for Level V. Data sources included relevant literature identified through searches of PubMed and EMBASE from 1966 to June 2017, and manual searches of the bibliographies of known primary and review articles. Results: Over 100 manuscripts were considered for inclusion. Of these, 8 studies met inclusion criteria for diagnostic accuracy and prevalence with 5 studies assessing lumbar provocation discography and 3 studies assessing cervical discography. The results showed variable prevalence from 16.9% to 26% for discogenic pain and 16.9% to 42% for internal disc disruption. The cervical discogenic pain prevalence ranged from 16% to 53%. Based on methodological quality assessment criteria the strength of evidence for lumbar provocation discography is Level III and for cervical discogenic pain is Level IV. Limitations: Despite multiple publications in the lumbar spine, value and validity of discography continues to be debated. In reference to cervical and thoracic discography, the available literature and value and validity continues to be low. Conclusion: This systematic review illustrates that lumbar provocation discography performed according to the International Association for the Study of Pain (IASP) criteria may be a useful tool for evaluating chronic lumbar discogenic pain. The evidence is weaker for cervical and nonexistent for thoracic discography. Key words: Lumbar intervertebral disc, cervical intervertebral disc, thoracic intervertebral disc, discography, provocation discography, analgesic discography, diagnostic accuracy, prevalence

The Two Micron All-Sky Survey (2MASS) Redshift Survey was started two decades ago with the goal of mapping the three-dimensional distribution of an all-sky flux-limited (K s < 11.75 mag) sample of ~45,000 galaxies. Our first data release presented an unprecedented uniform coverage for most of the celestial sphere, with redshifts for ~98% of our sample. However, we were missing redshifts for ~18% of the catalog entries that were located within the "Zone of Avoidance" ($| b| \lt 10^\circ $)—an important region of the sky for studies of the large-scale structure and cosmic flows. In this second and final data release, we present redshifts for all 1041 2MRS galaxies that previously lacked this information, as well as updated measurements for 27 others. Fil: Macri, Lucas M.. Texas A&M University; Estados Unidos Fil: Kraan Korteweg, Renee Christine. University of Cape Town; Sudáfrica Fil: Lambert, Trystan. South African Astronomical Observatory; Sudáfrica Fil: Alonso, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; Argentina Fil: Berlind, Perry. South African Astronomical Observatory; Sudáfrica Fil: Calkins, Michael. Harvard-Smithsonian Center for Astrophysics; Estados Unidos Fil: Erdogdu, Pirin. University College London. Department of Physics and Astronomy; Reino Unido Fil: Falco, Emilio. Harvard-Smithsonian Center for Astrophysics; Estados Unidos Fil: Jarrett, Thomas. University of Cape Town; Sudáfrica Fil: Mink, Jessica. Harvard-Smithsonian Center for Astrophysics; Estados Unidos

We test the recently proposed (Mediavilla et al. 2018) black hole mass scaling relationship based on the redshift {with respect to the quasar's rest frame} of the Fe III$\lambda\lambda$2039-2113 line blend. To this end, we fit this feature in the spectra of a well suited sample of quasars, observed with X-shooter at the Very Large Telescope (VLT), whose masses have been independently estimated using the virial theorem. For the quasars of this sample we consistently confirm the redshift of the Fe III$\lambda\lambda$2039-2113 blend and find that it correlates with the squared widths of H$\beta$, H$\alpha$ and Mg II, which are commonly used as a measure of $M_{BH}/R$ to determine masses from the virial theorem. The average differences between virial and Fe III$\lambda\lambda$2039-2113 redshift based masses are 0.18$\pm 0.21$ dex, 0.18$\pm 0.22$ dex and 0.14$\pm 0.21$ dex, when the full widths at half maximum (FWHM) of the H$\beta$, H$\alpha$ and MgII lines are, respectively, used. The difference is reduced to 0.10$\pm 0.16$ dex when the standard deviation, $\sigma$, of {the} MgII line is used, instead. We also study the high S/N composite quasar spectra of the Baryon Oscillation Spectroscopic Survey (BOSS), finding that the Fe III$\lambda\lambda$2039-2113 redshifts and Mg II squared widths, $FWHM_{MgII}^2$, match very well the correlation found for the individual quasar spectra observed with X-shooter. This correlation is expected if the redshift is gravitational.

We report the discovery and characterization of 7 transiting exoplanets from the HATNet survey. The planets, which are hot Jupiters and Saturns transiting bright sun-like stars, include: HAT-P-58b (with mass Mp = 0.37 MJ, radius Rp = 1.33 RJ, and orbital period P = 4.0138 days), HAT-P-59b (Mp = 1.54 MJ, Rp = 1.12 RJ, P = 4.1420 days), HAT-P-60b (Mp = 0.57 MJ, Rp = 1.63 RJ, P = 4.7948 days), HAT-P-61b (Mp = 1.06 MJ, Rp = 0.90 RJ, P = 1.9023 days), HAT-P-62b (Mp = 0.76 MJ, Rp = 1.07 RJ, P = 2.6453 days), HAT-P-63b (Mp = 0.61 MJ, Rp = 1.12 RJ, P = 3.3777 days), and HAT-P-64b (Mp = 0.58 MJ, Rp = 1.70 RJ, P = 4.0072 days). The typical errors on these quantities are 0.06 MJ, 0.03 RJ, and 0.2seconds, respectively. We also provide accurate stellar parameters for each of the hosts stars. With V = 9.710+/-0.050mag, HAT-P-60 is an especially bright transiting planet host, and an excellent target for additional follow-up observations. With Rp = 1.703+/-0.070 RJ, HAT-P-64b is a highly inflated hot Jupiter around a star nearing the end of its main-sequence lifetime, and is among the largest known planets. Five of the seven systems have long-cadence observations by TESS which are included in the analysis. Of particular note is HAT-P-59 (TOI-1826.01) which is within the Northern continuous viewing zone of the TESS mission, and HAT-P-60, which is the TESS candidate TOI-1580.01., Comment: Submitted to AJ. Many large figures and tables at the end of the paper

Background: Treatment of chronic hepatitis B (CHB) with polymerase inhibitors is key to prevent disease flares and progression toward advanced liver disease. Efficacy and tolerability of newer agents has been reported anecdotally in transplant recipients. Methods: In this prospective, observational study, we assessed outcomes of therapy with tenofovir (TDF), entecavir (ETV), and telbivudine (LdT) in 13 heart transplant recipients (HTR) with CHB. Results: Most patients were hepatitis B e antigen negative, had low baseline hepatitis B virus (HBV) DNA, and normal aminotransferases. Liver biopsy showed a median fibrosis score of 1.5 (range 0–4). Glomerular filtration rate (GFR) was

The origin of short timescale (weeks/months) variability of AGN, whether due to intrinsic disc variations or reprocessing of X-ray emission by a surrounding accretion disc, has been a puzzle for many years. However recently a number of observational programmes, particularly of NGC 5548 with Swift, have shown that the UV/optical variations lag behind the X-ray variations in a manner strongly supportive of X-ray reprocessing. Somewhat surprisingly, the implied size of the accretion disc is ?3 times greater than expected from a standard, smooth, Shakura-Sunyaev thin disc model. Although the difference may be explained by a clumpy accretion disc, it is not clear whether the difference will occur in all AGN or whether it may change as, eg, a function of black hole mass, accretion rate, or disc temperature. Measurements of interband lags for most AGN require long timescale monitoring, which is hard to arrange. However for low mass (

We present results on multifrequency Very Long Baseline Array (VLBA) monitoring observations of the double-image gravitationally lensed blazar JVAS B0218+357. Multi-epoch observations started less than one month after the gamma-ray flare detected in 2012 by the Large Area Telescope on board Fermi, and spanned a 2-month interval. The radio light curves did not reveal any significant flux density variability, suggesting that no clear correlation between the high energy and low-energy emission is present. This behaviour was confirmed also by the long-term Owens Valley Radio Observatory monitoring data at 15 GHz. The milliarcsecond-scale resolution provided by the VLBA observations allowed us to resolve the two images of the lensed blazar, which have a core-jet structure. No significant morphological variation is found by the analysis of the multi-epoch data, suggesting that the region responsible for the gamma-ray variability is located in the core of the AGN, which is opaque up to the highest observing frequency of 22 GHz., 9 pages, 6 figures, 3 tables. Accepted for publication in MNRAS

The MINiature Exoplanet Radial Velocity Array (MINERVA) is a dedicated observatory of four 0.7m robotic telescopes fiber-fed to a KiwiSpec spectrograph. The MINERVA mission is to discover super-Earths in the habitable zones of nearby stars. This can be accomplished with MINERVA's unique combination of high precision and high cadence over long time periods. In this work, we detail changes to the MINERVA facility that have occurred since our previous paper. We then describe MINERVA's robotic control software, the process by which we perform 1D spectral extraction, and our forward modeling Doppler pipeline. In the process of improving our forward modeling procedure, we found that our spectrograph's intrinsic instrumental profile is stable for at least nine months. Because of that, we characterized our instrumental profile with a time-independent, cubic spline function based on the profile in the cross dispersion direction, with which we achieved a radial velocity precision similar to using a conventional "sum-of-Gaussians" instrumental profile: 1.8 m s$^{-1}$ over 1.5 months on the RV standard star HD 122064. Therefore, we conclude that the instrumental profile need not be perfectly accurate as long as it is stable. In addition, we observed 51 Peg and our results are consistent with the literature, confirming our spectrograph and Doppler pipeline are producing accurate and precise radial velocities., Comment: 22 pages, 9 figures, submitted to PASP, Peer-Reviewed and Accepted

We study the broad emission lines in a sample of 11 gravitationally lensed quasars with at least two epochs of observation to identify intrinsic variability and to disentangle it from microlensing. To improve our statistical significance and emphasize trends, we also include 15 lens systems with single-epoch spectra. Mg ii and C iii] emission lines are only weakly affected by microlensing, but C iv shows strong microlensing in some cases, even for regions of the line core, presumably associated with small projected velocities. However, excluding the strongly microlensed cases, there is a strikingly good match, on average, between the red wings of the C iv and C iii] profiles. Analysis of these results supports the existence of two regions in the broad-line region (BLR), one that is insensitive to microlensing (of size 50 lt-day and kinematics not confined to a plane) and another that shows up only when it is magnified by microlensing (of size of a few light-days, comparable to the accretion disk). Both regions can contribute in different proportions to the emission lines of different species and, within each line profile, to different velocity bins, all of which complicates detailed studies of the BLR based on microlensing size estimates. The strength of the microlensing indicates that some spectral features that make up the pseudo-continuum, such as the shelf-like feature at λ1610 or several Fe iii blends, may in part arise from an inner region of the accretion disk. In the case of Fe ii, microlensing is strong in some blends but not in others. This opens up interesting possibilities to study quasar accretion disk kinematics. Intrinsic variability seems to affect the same features prone to microlensing, with similar frequency and amplitude, but does not induce outstanding profile asymmetries. We measure intrinsic variability (≲20%) of the wings with respect to the cores in the C iv, C iii], and Mg ii lines consistent with reverberation mapping studies.

We present ground-based and Swift photometric and spectroscopic observations of the candidate tidal disruption event (TDE) ASASSN-14li, found at the center of PGC 043234 ($d\simeq90$ Mpc) by the All-Sky Automated Survey for SuperNovae (ASAS-SN). The source had a peak bolometric luminosity of $L\simeq10^{44}$ ergs s$^{-1}$ and a total integrated energy of $E\simeq7\times10^{50}$ ergs radiated over the $\sim6$ months of observations presented. The UV/optical emission of the source is well-fit by a blackbody with roughly constant temperature of $T\sim35,000$ K, while the luminosity declines by roughly a factor of 16 over this time. The optical/UV luminosity decline is broadly consistent with an exponential decline, $L\propto e^{-t/t_0}$, with $t_0\simeq60$ days. ASASSN-14li also exhibits soft X-ray emission comparable in luminosity to the optical and UV emission but declining at a slower rate, and the X-ray emission now dominates. Spectra of the source show broad Balmer and helium lines in emission as well as strong blue continuum emission at all epochs. We use the discoveries of ASASSN-14li and ASASSN-14ae to estimate the TDE rate implied by ASAS-SN, finding an average rate of $r \simeq 4.1 \times 10^{-5}~{\rm yr}^{-1}$ per galaxy with a 90% confidence interval of $(2.2 - 17.0) \times 10^{-5}~{\rm yr}^{-1}$ per galaxy. ASAS-SN found roughly 1 TDE for every 70 Type Ia supernovae in 2014, a rate that is much higher than that of other surveys., 21 pages, 9 figures, 6 tables. Photometric data presented in this submission are included as ancillary files. Manuscript updated to reflect changes made in the published version. For a brief video explaining this paper, see https://youtu.be/CTbr-d7cWZc

The Kepler mission has shown that small planets are extremely common. It is likely that nearly every star in the sky hosts at least one rocky planet. We just need to look hard enough - but this requires vast amounts of telescope time. MINERVA (MINiature Exoplanet Radial Velocity Array) is a dedicated exoplanet observatory with the primary goal of discovering rocky, Earth-like planets orbiting in the habitable zone of bright, nearby stars. The MINERVA team is a collaboration among UNSW Australia, Harvard-Smithsonian Center for Astrophysics, Penn State University, University of Montana, and the California Institute of Technology. The four-telescope MINERVA array will be sited at the F.L. Whipple Observatory on Mt Hopkins in Arizona, USA. Full science operations will begin in mid-2015 with all four telescopes and a stabilised spectrograph capable of high-precision Doppler velocity measurements. We will observe 100 of the nearest, brightest, Sun-like stars every night for at least five years. Detailed simulations of the target list and survey strategy lead us to expect 154 new low-mass planets.

We report the discovery of a new transiting extrasolar planet, HAT-P-55b . The planet orbits a V = 13.207 ± 0.039 sun-like star with a mass of 1.013 ± 0.037 M⊙, a radius of 1.011 ± 0.036 R⊙, and a metallicity of -0.03 ± 0.08. The planet itself is a typical hot Jupiter with a period of 3.5852467 ± 0.0000064 days, a mass of 0.582 ± 0.056 MJ and a radius of 1.182 ± 0.055 RJ. This discovery adds to the increasing sample of transiting planets with measured bulk densities, which is needed to put constraints on models of planetary structure and formation theories.

We examined perception of artificial timbre blending using recordings of two actual instruments. In Experiment 1, participants heard stimuli comprising different proportions of sounds from an oboe and a trumpet, constructed using both a linear and a logarithmic algorithm, and judged the degree of blending. In Experiment 2, participants chose between an oboe and a trumpet in each blend condition. In both experiments, participants were able to track the degrees of blending between the two anchor points quite accurately. In Experiment 3, participants matched test blends to two target blends in an ABX design and showed no evidence for categorical perception of oboe and trumpet timbres in their judgments. Further, participants with and without musical training showed similar patterns of responding. The findings suggest a high level of sensitivity for timbre coding in auditory perception and also have implications for timbre manipulation as a compositional device and sound morphing techniques.

In summary, the SGR continues to hang like Damocles sword over physicians. To understand health care needs, we need to separate basic health care needs from economic mandates, and health insurance from health care coverage. The SGR flux represents another meaningful uncertainty to this health care conundrum.

Background: The rapid increase in the prevalence of chronic pain and disability, and the explosion of interventional pain management associated health care costs are a major concern for our community. Further, the increasing utilization of numerous modalities of treatments in managing chronic pain, continue to escalate at a pace which may not be sustainable. There are multiple regulations in place to control the growth of health care expenditures which seem to have been largely ineffective. Among the various modalities utilized in managing chronic pain, interventional techniques have shown a significant increase in their utilization in the face of continued debate with respect to the accuracy of diagnostic interventions and the efficacy of therapeutic interventions. Objective: To update and assess the utilization of interventional techniques in chronic pain management in fee-for-service Medicare population. Study Design: An updated analysis of the growth of interventional techniques in managing chronic pain in fee-for-service Medicare beneficiaries from 2000 through 2013. Methods: The data were derived and analyzed utilizing the Centers for Medicare and Medicaid Services (CMS) Physician Supplier Procedure Summary Master Data from 2000 through 2013. Results: From 2000 through 2013, in fee-for-service Medicare beneficiaries, the overall utilization of interventional techniques services increased 236% at an annual average growth of 9.8%, whereas the per 100,000 Medicare population utilization increased 156% with an annual average growth of 7.5%. During this period, the US population increased 12% with an annual average increase of 0.9%, whereas those above 65 years of age increased 27% with an annual average increase of 1.9%. Total Medicare beneficiaries increased 31% with an annual average increase of 2.1%, with an overall increase of 64% for those above 65 years of age, an increase of 26%, constituting 17% of the US population in 2013. The overall increases in epidural and adhesiolysis procedures were 165% compared to 102% per 100,000 fee-for-service population with annual average increases of 7.8% and 5.6%. Facet joint and sacroiliac joint injections increased 417% for services with an annual average increase of 13.5%, whereas the rate per 100,000 fee-for-service Medicare beneficiaries increased 295% with an annual average increase of 11.1%. Limitations: Limitations of this assessment include the lack of inclusion of participants from Medicare Advantage plans, lack of appropriate available data for state-wide utilization, and potential errors in documentation, coding, and billing. Conclusion: This update once again shows a significant increase in interventional techniques in feefor-service Medicare beneficiaries from 2000 through 2013 with an increase of 156% per 100,000 Medicare population with an annual average increase of 7.5%. During this period the Medicare population increased 31% with an annual average increase of 2.1%. Key words: Chronic pain, chronic spinal pain, interventional pain management, interventional techniques, epidural injections, facet joint interventions, sacroiliac joint injections

While it appears to be beneficial to apply a detailed disease classification system, the costs, cash flow disruptions, and increased investments with physician time incorporated into learning these processes, patient care might unfortunately suffer. This is essentially an unfunded mandate with much of the burden of transitioning to ICD-10 falling on health care providers,especially small independent practices. This will impact interventional pain management practices substantially.Further, as we have shown in previous manuscripts,the so-called advantages of multiple codes with specificity and granularity does not translate into reality where some specificity is actually lost for various codes. As Grimsley and O'Shea (1) have described in clinical practices, doctors do not treat codes, but they treat patients according to the individual clinical condition.A doctor will be losing valuable time and also will not be able to obtain meaningful information due to burdensome regulations of meaningful use, PQRS,value-based reimbursement, electronic prescribing,and now a major impact with change to ICD-10. Thus,very little benefit will be seen by practitioners, which cannot be said for the health care information industry.With overwhelming regulatory atmosphere created by numerous federal regulations and those including under the Affordable Care Act (15), there is no evidence that ICD-10 is needed, there is no evidence that it will be effective, and, finally, there is preponderance of evidence of adverse consequences. Thus, Congress should be cautious in imposing further regulations on already strained independent practices with ongoing regulations and imposing yet another unfunded mandate on the medical profession.

We present optical photometry and spectroscopy of the Type II supernova ASASSN-14jb, together with VLT MUSE IFU observations of its host galaxy and a nebular-phase spectrum. This SN, in the nearby galaxy ESO 467-G051 ($z=0.006$), was discovered and followed-up by the All Sky Automated Survey for SuperNovae (ASAS-SN). We present LCOGTN $BVgri$ and $Swift$ $w2m1w1ubv$ optical and near-UV/optical light curves and several optical spectra in the early photospheric phase. ASASSN-14jb exploded $\sim 2$ kpc above the star-forming disk of ESO 467-G051, an edge-on disk galaxy. The large projected distance from the disk and non-detection of any H II region in a 1.4 kpc radius in projection are in conflict with the standard environment of core-collapse supernova progenitors and suggests the possible scenario that the progenitor received a kick in a binary interaction. Our analysis yields $D=25\pm 1$ Mpc, $M(^{56}Ni) = 0.0210 \pm 0.0025$ M$_\odot$, $E_{exp}\approx 0.25 \times 10^{51}$ ergs, $M_{ej}\approx 6$ M$_\odot$, and progenitor $R_* = 580 \pm 28$ R$_\odot$, which seems to be consistent with the sub-Solar metallicity of $0.3 \pm 0.1$ Z$_\odot$ derived from the SN spectrum. The nebular spectrum constrains $M_{prog} \simeq 10-12 $ M$_{\odot}$. We discuss the low oxygen abundance of the host galaxy derived from the MUSE data, $12+\log{(O/H)} = 8.27^{+0.16}_{-0.20}$ (O3N2 strong line method), and compare it with the supernova spectra, which is also consistent with a sub-Solar metallicity progenitor. We finally discuss the possible scenarios for the unusual environment for ASASSN-14jb and conclude that either the in-situ star formation or a runaway would imply a low mass progenitor, agreeing with our estimate from the supernova nebular spectrum. We show that the detailed study of the environment can agree with the stronger constrains of the transient observations. (abridged), Comment: 24 pages, submitted to A&A

Chronic neck pain with or without upper extremity pain or headaches is relatively common in the adult population secondary to disc herniation, discogenic pain, spinal stenosis, spondylosis, and post-surgery syndrome. Treatments for chronic neck pain, recalcitrant to conservative management resulting in disability, include surgical management as well as interventional techniques with epidural injections utilizing either an interlaminar approach or transforaminal approach. Even though there have been multiple systematic reviews and randomized clinical trials of efficacy of cervical interlaminar epidural injections, the literature is sparse in reference to cervical transforaminal epidural injections. In addition, cervical transforaminal epidural injections have been associated with an inordinate risk.

Lumbar epidural injections are administered by accessing the epidural space either by caudal, interlaminar, or transforaminal approaches. Epidural injections are administered to manage chronic low back pain with or without lower extremity pain secondary to disc herniation, discogenic pain without facet joint pain, spinal stenosis, post-lumbar surgery syndrome, and degenerative disc disease.

Managing antithrombotic and antiplatelet therapy is one of the common issues while performing interventional techniques to balance the bleeding risk and perioperative risk of thrombosis. There are myriad procedural guidelines on managing anticoagulant and antithrombotic therapy, even though most are not based on appropriate evidence.

Hydrogen-poor superluminous supernovae (SLSNe-I) have been predominantly found in low-metallicity, star-forming dwarf galaxies. Here we identify Gaia17biu/SN 2017egm as an SLSN-I occurring in a "normal" spiral galaxy (NGC 3191) in terms of stellar mass (several times 10^10 M_sun) and metallicity (roughly Solar). At redshift z=0.031, Gaia17biu is also the lowest redshift SLSN-I to date, and the absence of a larger population of SLSNe-I in dwarf galaxies of similar redshift suggests that metallicity is likely less important to the production of SLSNe-I than previously believed. With the smallest distance and highest apparent brightness for an SLSN-I, we are able to study Gaia17biu in unprecedented detail. Its pre-peak near-ultraviolet to optical color is similar to that of Gaia16apd and among the bluest observed for an SLSN-I while its peak luminosity (M_g = -21 mag) is substantially lower than Gaia16apd. Thanks to the high signal-to-noise ratios of our spectra, we identify several new spectroscopic features that may help to probe the properties of these enigmatic explosions. We detect polarization at the ~0.5% level that is not strongly dependent on wavelength, suggesting a modest, global departure from spherical symmetry. In addition, we put the tightest upper limit yet on the radio luminosity of an SLSN-I with, Accepted for publication in ApJ. Ancillary ASCII tables added: TRL.txt -- blackbody temperature, radius and luminosity; uvw2uvm2uvw1uvu.txt -- UV photometry; BgVri.txt -- optical photometry; zJHK.txt -- NIR photometry

We find that the Fe III$\lambda\lambda$2039-2113 spectral feature in quasars appears systematically redshifted by amounts accountable under the hypothesis of gravitational redshift induced by the central supermassive black hole. Our analysis of 27 composite spectra from the BOSS survey indicates that the redshift and the broadening of the lines in the Fe III$\lambda\lambda$2039-2113 blend roughly follow the expected correlation in the weak limit of Schwarzschild geometry for virialized kinematics. Assuming that the Fe III UV redshift provides a measure of $M_{BH}\over R$ (${\Delta \lambda\over \lambda}\simeq{3\over2}{G\over c^2} {M_{BH}\over R}$) and using different estimates of the emitting region size, $R$ (either from gravitational microlensing, reverberation mapping or from the scaling of size with intrinsic quasar luminosity), we obtain masses for 10 objects which are in agreement within uncertainties with previous mass estimates based on the virial theorem. Reverberation mapping estimates of the size of the Fe III$\lambda\lambda$2039-2113 emitting region in a sample of objects would be needed to confirm the gravitational origin of the measured redshifts. Meanwhile, we present a tentative black hole mass scaling relationship based on the Fe III$\lambda\lambda$2039-2113 redshift useful to measure the black hole mass of one individual object from a single spectrum.