1,086 results on '"E., Howell"'
Search Results
2. Examining user-generated content, service failure recovery and customer-brand relationships: an exploration through commitment-trust theory.
- Author
-
Wilson Ozuem, Michelle Willis, Kerry E. Howell, Silvia Ranfagni, and Serena Rovai
- Published
- 2024
- Full Text
- View/download PDF
3. Using an mHealth approach to collect patient-generated health data for predicting adverse health outcomes among adult survivors of childhood cancer
- Author
-
Kristen E. Howell, Marian Shaw, Aimee K. Santucci, Kristy Rodgers, Izeris Ortiz Rodriguez, Danah Taha, Sara Laclair, Carol Wolder, Christie Cooper, Wonjong Moon, Christopher Vukadinovich, Matthew J. Erhardt, Shannon M. Dean, Gregory T. Armstrong, Kirsten K. Ness, Melissa M. Hudson, Yutaka Yasui, and I-Chan Huang
- Subjects
childhood cancer survivors ,electronic health record ,late effects ,machine learning ,mHealth ,patient-generated health data ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionCancer therapies predispose childhood cancer survivors to various treatment-related late effects, which contribute to a higher symptom burden, chronic health conditions (CHCs), and premature mortality. Regular monitoring of symptoms between clinic visits is useful for timely medical consultation and interventions that can improve quality of life (QOL). The Health Share Study aims to utilize mHealth to collect patient-generated health data (PGHD; daily symptoms, momentary physical health status) and develop survivor-specific risk prediction scores for mitigating adverse health outcomes including poor QOL and emergency room admissions. These personalized risk scores will be integrated into the hospital-based electronic health record (EHR) system to facilitate clinician communications with survivors for timely management of late effects.MethodsThis prospective study will recruit 600 adult survivors of childhood cancer from the St. Jude Lifetime Cohort study. Data collection include 20 daily symptoms via a smartphone, objective physical health data (physical activity intensity, sleep performance, and biometric data including resting heart rate, heart rate variability, oxygen saturation, and physical stress) via a wearable activity monitor, patient-reported outcomes (poor QOL, unplanned healthcare utilization) via a smartphone, and clinically ascertained outcomes (physical performance deficits, onset of/worsening CHCs) assessed in the survivorship clinic. Participants will complete health surveys and physical/functional assessments in the clinic at baseline, 2) report daily symptoms, wear an activity monitor, measure blood pressure at home over 4 months, and 3) complete health surveys and physical/functional assessments in the clinic 1 and 2 years from the baseline. Socio-demographic and clinical data abstracted from the EHR will be included in the analysis. We will invite 20 cancer survivors to investigate suitable formats to display predicted risk information on a dashboard and 10 clinicians to suggest evidence-based risk management strategies for adverse health outcomes.AnalysisMachine and statistical learning will be used in prediction modeling. Both approaches can handle a large number of predictors, including longitudinal patterns of daily symptoms/other PGHD, along with cancer treatments and socio-demographics.ConclusionThe individualized risk prediction scores and added communications between providers and survivors have the potential to improve survivorship care and outcomes by identifying early clinical presentations of adverse events.
- Published
- 2024
- Full Text
- View/download PDF
4. Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study
- Author
-
Amy E. Howell, Caroline Relton, Richard M. Martin, Jie Zheng, and Kathreena M. Kurian
- Subjects
Medicine ,Science - Abstract
Abstract Genetic evidence suggests glioma risk is altered by leukocyte telomere length, allergic disease (asthma, hay fever or eczema), alcohol consumption, childhood obesity, low-density lipoprotein cholesterol (LDLc) and triglyceride levels. DNA methylation (DNAm) variation influences many of these glioma-related traits and is an established feature of glioma. Yet the causal relationship between DNAm variation with both glioma incidence and glioma risk factors is unknown. We applied a two-step Mendelian randomization (MR) approach and several sensitivity analyses (including colocalization and Steiger filtering) to assess the association of DNAm with glioma risk factors and glioma incidence. We used data from a recently published catalogue of germline genetic variants robustly associated with DNAm variation in blood (32,851 participants) and data from a genome-wide association study of glioma risk (12,488 cases and 18,169 controls, sub-divided into 6191 glioblastoma cases and 6305 non-glioblastoma cases). MR evidence indicated that DNAm at 3 CpG sites (cg01561092, cg05926943, cg01584448) in one genomic region (HEATR3) had a putative association with glioma and glioblastoma risk (False discovery rate [FDR]
- Published
- 2023
- Full Text
- View/download PDF
5. The development of a convolutional neural network for the automatic detection of Northern Bobwhite Colinus virginianus covey calls
- Author
-
Victoria Nolan, Chris Scott, John M. Yeiser, Nathan Wilhite, Paige E. Howell, Dallas Ingram, and James A. Martin
- Subjects
Acoustic recording ,autonomous recording unit ,convolutional neural network ,covey call ,machine learning ,northern bobwhite ,Technology ,Ecology ,QH540-549.5 - Abstract
Abstract Passive acoustic monitoring using Autonomous Recording Units (ARUs) is becoming a significant research tool for collecting large amounts of ecological data. Northern bobwhite Colinus virginianus is an economically important game bird whose declining populations are of conservation concern, so efforts to monitor bobwhite abundance using ARUs are being intensified. Yet, manual processing of ARU data is time consuming and often expensive, so developing automatic call detection methods is a key step in acoustic monitoring. We present here the first single species convolutional neural network (CNN) developed purely for automatic bobwhite covey call identification and classification. We demonstrate the value of meaningful data augmentation by including non‐target calls and background noise into our training dataset, as well as evaluating alternative CNN score thresholds and model extrapolation performance. We trained our CNN on 6,682 manually labeled covey calls across three groups of sites within the southeastern USA. Precision and AUC from both CNN classification and individual call detection was high (0.80–0.99), and our model showed strong extrapolation ability across site groups. However, extrapolation performance significantly decreased for sites that were more dissimilar to the training data set if our meaningful data augmentation process was omitted. Our CNN detected significantly more covey calls than manual labeling using Raven Pro software, and processing time was greatly reduced: a single one hour wav file can be now analyzed by the CNN in roughly eight seconds. We also demonstrate using a simple case study that extremely high variability in estimates of bobwhite site occupancy and detection are obtained depending on the method of acoustic data processing (manual versus CNN). Our results suggest that our CNN provides robust and time‐saving analysis of bobwhite covey call acoustic data and can be applied to future research and monitoring projects with high confidence in the performance of the model.
- Published
- 2023
- Full Text
- View/download PDF
6. Burden of Aging: Health Outcomes Among Adolescents and Young Adults With Sickle Cell Disease
- Author
-
Kristen E. Howell, Norma Pugh, Jennifer Longoria, Nirmish Shah, Abdullah Kutlar, Victor R. Gordeuk, Allison A. King, Jeffrey Glassberg, Mariam Kayle, Cathy Melvin, Marsha Treadwell, Jane S. Hankins, Jerlym S. Porter, and on behalf of the Sickle Cell Disease Implementation Consortium
- Subjects
Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
- Full Text
- View/download PDF
7. Why Do Key Decision-Makers Fail to Foresee Extreme 'Black Swan' Events? A Case Study of the Pike River Mine Disaster, New Zealand.
- Author
-
Richard John Logan, Robert Y. Cavana, Bronwyn E. Howell, and Ian Yeoman
- Published
- 2024
- Full Text
- View/download PDF
8. DIII-D research to provide solutions for ITER and fusion energy
- Author
-
C.T. Holcomb, for the DIII-D Team:, J. Abbate, A. Abe, A. Abrams, P. Adebayo-Ige, S. Agabian, S. Ahmed, N. Aiba, N. Akcay, T. Akiyama, R. Albosta, P. Aleynikov, S. Allen, H. Anand, J. Anderson, Y. Andrew, M. Ashburn, A. Ashourvan, M. Austin, G. Avdeeva, D. Ayala, M. Ayub, E. Bagdy, S. Banerjee, K. Barada, L. Bardoczi, O. Bardsley, J. Barr, E. Bass, A. Battey, Z. Bayler, L. Baylor, T. Bechtel, M. Beidler, E. Belli, T. Benedett, Z. Bergstrom, M. Berkel, T. Bernard, N. Bertelli, R. Bielajew, G. Bodner, J. Boedo, R. Boivin, T. Bolzonella, P. Bonoli, A. Bortolon, S. Bose, M. Boyer, W. Boyes, L. Bradley, R. Brambila, A. Braun, D. Brennan, S. Bringuier, L. Brodsky, M. Brookman, J. Brooks, D. Brower, W. Brown, J. Buck, S. Buczek, D. Burgess, M. Burke, K. Burrell, J. Butt, R. Buttery, I. Bykov, P. Byrne, A. Cacheris, K. Callahan, J. Callen, D. Campbell, J. Candy, J. Canik, L. Cappelli, T. Carlstrom, R. Carr, W. Carrig, B. Carter, T. Carter, I. Carvalho, W. Cary, L. Casali, L. Ceelen, M. Cengher, M. Cha, R. Chaban, V. Chan, B. Chapman, I. Char, J. Chen, R. Chen, X. Chen, Y. Chen, J. Chiriboga, E. Cho, G. Choi, W. Choi, H. Choudhury, S. Chowdhury, C. Chrystal, Y. Chung, R. Churchill, R. Clark, M. Clement, J. Coburn, S. Coda, R. Coffee, C. Collins, J. Colmenares-Fernandez, W. Conlin, R. Coon, T. Cote, A. Creely, N. Crocker, C. Crowe, B. Crowley, T. Crowley, M. Curie, D. Curreli, A. Dal Molin, J. Damba, E. Dart, A. Dautt-Silva, K. Davda, A. De, N. de Boucaud, Y. de Jong, P. DE VRIES, A. de-Villeroche, G. DeGrandchamp, J. deGrassie, D. Demers, S. Denk, E. DeShazer, S. Di Genova, A. Diallo, A. Dimits, R. Ding, S. Ding, D. Donovan, X. Du, J. Dunsmore, A. Dupuy, J. Duran, A. Dvorak, F. Effenberg, N. Eidietis, D. Elder, D. Eldon, Y. Elsey, D. Ennis, K. Erickson, D. Ernst, M. Fajardo, H. Farre-Kaga, M. Fenstermacher, N. Ferraro, J. Ferron, A. Feyrer, P. Fimognari, R. Finden, D. Finkenthal, R. Fitzpatrick, S. Flanagan, B. Ford, W. Fox, S. Freiberger, L. Fu, K. Gage, V. Gajaraj, I. Garcia, F. Garcia, A. Garcia, M. Garcia Munoz, D. Garnier, A. Garofalo, A. Gattuso, B. Geiger, K. Gentle, Y. Ghai, K. Gill, F. Glass, P. Gohil, X. Gong, J. Gonzalez-Martin, Y. Gorelov, V. Graber, R. Granetz, C. Gray, C. Greenfield, B. Grierson, R. Groebner, W. Grosnickle, M. Groth, S. Gu, H. Guo, J. Guterl, W. Guttenfelder, R. Hager, S. Hahn, M. Halfmoon, J. Hall, V. Hall-Chen, F. Halpern, G. Hammett, X. Han, C. Hansen, E. Hansen, J. Hanson, M. Hanson, A. Harris, R. Harvey, S. Haskey, D. Hatch, W. Hayashi, A. Hayes, W. Heidbrink, J. Herfindal, J. Hicok, E. Hinson, T. Hisakado, C. Holcomb, C. Holland, L. Holland, E. Hollmann, A. Holm, I. Holmes, K. Holtrop, R. Hong, R. Hood, L. Horvath, S. Houshmandyar, N. Howard, E. Howell, W. Hu, Y. Hu, Q. Hu, Y. Huang, J. Huang, A. Huang, A. Hubbard, J. Hughes, D. Humphreys, J. Hurtado, A. Hyatt, K. Imada, V. Izzo, A. Jalalvand, S. Jardin, A. Jarvinen, Y. Jeon, H. Ji, X. Jian, L. Jian, Y. Jiang, C. Johnson, J. Johnson, M. Jones, S. Joung, P. Jouzdani, E. Jung, E. Kallenberg, R. Kalling, D. Kaplan, A. Kaptanoglu, D. Kellman, J. Kennedy, F. Khabanov, J. Kim, H. Kim, E. Kim, S. Kim, K. Kim, C. Kim, T. Kim, J. King, A. Kinsey, D. Kirk, D. Klasing, A. Kleiner, M. Knolker, M. Kochan, B. Koel, J. Koenders, M. Koepke, R. Kolasinski, E. Kolemen, E. Kostadinova, M. Kostuk, G. Kramer, R. Kube, N. Kumar, R. La Haye, F. Laggner, C. Lahban, H. Lan, R. Landry, R. Lantsov, L. Lao, C. Lasnier, C. Lau, R. Leccacorvi, J. Leddy, M. Lee, S. Lee, K. Lee, R. Lee, M. Lehnen, A. Leonard, E. Leppink, M. LeSher, J. Lestz, J. Leuer, N. Leuthold, G. Li, X. Li, Y. Li, L. Li, N. Li, Z. Li, D. Lin, Z. Lin, Y. Lin, E. Linsenmayer, J. Liu, D. Liu, C. Liu, Z. Liu, Y. Liu, A. Loarte-Prieto, S. Loch, L. LoDestro, N. Logan, J. Lohr, J. Lore, U. Losada Rodriguez, J. Loughran, M. Lowell, T. Luce, N. Luhmann, P. Lunia, R. Lunsford, L. Lupin-Jimenez, A. Lvovskiy, B. Lyons, X. Ma, J. MacDonald, T. Macwan, R. Maingi, M. Major, L. Malhotra, M. Margo, C. Marini, A. Marinoni, A. Maris, E. Martin, J. Mateja, R. Mattes, R. Maurizio, D. Mauzey, L. McAllister, G. McArdle, J. McClenaghan, K. McCollam, G. McKee, K. McLaughlin, A. McLean, V. Mehta, E. Meier, S. Meitner, J. Menard, O. Meneghini, G. Merlo, S. Messer, W. Meyer, C. Michael, D. Miller, M. Miller, J. Mitchell, E. Mitra, C. Moeller, M. Mohamed, S. Molesworth, K. Montes, S. Mordijck, S. Morosohk, A. Moser, D. Mueller, S. Munaretto, C. Murphy, C. Muscatello, R. Myers, A. Nagy, D. Nath, M. Navarro, R. Nazikian, T. Neiser, A. Nelson, P. Nesbet, F. Nespoli, P. Nguyen, D. Nguyen, R. Nguyen, J. Nichols, M. Nocente, L. Nuckols, R. Nygren, T. Odstrcil, M. Okabayashi, E. Olofsson, D. Orlov, D. Orozco, N. Osborne, T. Osborne, F. OShea, D. Pace, D. Packard, A. Pajares Martinez, C. Pakosta, C. Pan, M. Pandya, D. Panici, A. Pankin, Y. Park, J. Park, C. Parker, S. Parker, P. Parks, M. Parsons, S. Paruchuri, C. Paz-Soldan, T. Pederson, W. Peebles, B. Penaflor, E. Perez, L. Periasamy, R. Perillo, C. Petty, M. Pharr, D. Pierce, C. Pierren, S. Pierson, A. Pigarov, L. Pigatto, D. Piglowski, S. Pinches, R. Pinsker, R. Pitts, J. Pizzo, M. Podesta, Z. Popovic, M. Porkolab, Q. Pratt, G. Prechel, I. Pusztai, P. Puthan-Naduvakkate, J. Qian, X. Qin, O. Ra, T. Raines, K. Rakers, K. Rath, J. Rauch, C. Rea, R. Reed, A. Reiman, M. Reinke, R. Reksoatmodjo, Q. Ren, J. Ren, Y. Ren, M. Rensink, T. Rhodes, N. Richner, J. Ridzon, G. Riggs, J. Riquezes, P. Rodriguez Fernandez, T. Rognlien, G. Ronchi, L. Rondini, R. Rosati, A. Rosenthal, M. Ross, J. Rost, A. Rothstein, J. Roveto, J. Ruane, D. Rudakov, R. Rupani, G. Rutherford, S. Sabbagh, J. Sachdev, N. Sadeghi, A. Salmi, F. Salvador, B. Sammuli, C. Samuell, A. Sandorfi, C. Sang, D. Santa, J. Sarff, O. Sauter, H. Savelli, C. Schaefer, H. Schamis, J. Schellpfeffer, D. Schissel, L. Schmitz, O. Schmitz, P. Schroeder, K. Schultz, E. Schuster, F. Sciortino, F. Scotti, J. Scoville, A. Seltzman, J. Seo, J. Serrano, I. Sfiligoi, M. Shafer, R. Shapov, H. Shen, N. Shi, D. Shiraki, B. Short, R. Shousha, H. Si, C. Sierra, G. Sinclair, P. Sinha, G. Sips, C. Skinner, T. Slendebroek, J. Slief, R. Smirnov, S. Smith, D. Smith, G. Snoep, P. Snyder, W. Solomon, X. Song, A. Sontag, V. Soukhanovskii, D. Spong, J. Squire, G. Staebler, L. Stagner, T. Stange, P. Stangeby, E. Starling, S. Stewart, T. Stoltzfus-Dueck, S. Storment, E. Strait, D. Su, L. Sugiyama, P. Sun, Y. Sun, X. Sun, C. Sung, W. Suttrop, Y. Suzuki, R. Sweeney, B. Taczak, Y. Takemura, S. Tang, W. Tang, G. Tardini, D. Taussig, K. Teixeira, K. Thackston, D. Thomas, K. Thome, Y. Tinguely, M. Tobin, J. Tooker, A. Torrezan de Sousa, P. Traverso, G. Trevisan, E. Trier, D. Truong, C. Tsui, F. Turco, A. Turnbull, L. Turner, E. Unterberg, B. Van Compernolle, R. van Kampen, M. Van Zeeland, B. Victor, R. Vieira, E. Viezzer, S. Vincena, D. Vollmer, J. Wai, M. Walker, R. Waltz, W. Wampler, L. Wang, Y. Wang, H. Wang, Z. Wang, G. Wang, A. Wang, J. Watkins, M. Watkins, T. Watts, L. Webber, K. Weber, W. Wehner, X. Wei, D. Weisberg, A. Welander, A. Welsh, A. White, R. Wilcox, G. Wilkie, T. Wilks, M. Willensdorfer, H. Wilson, A. Wingen, M. Wu, D. Wu, S. Wukitch, J. Xia, R. Xie, Z. Xing, G. Xu, X. Xu, Z. Yan, X. Yang, L. Yang, S. Yang, J. Yang, M. Yoo, G. YU, J. Yu, A. Zalzali, A. Zamengo, V. Zamkovska, S. Zamperini, K. Zarrabi, E. Zeger, K. Zeller, L. Zeng, X. Zhang, J. Zhang, B. Zhang, B. Zhao, C. Zhao, Y. Zheng, Y. Zhu, J. Zhu, J. Ziegel, J. Zimmerman, and C. Zuniga
- Subjects
DIII-D ,tokamak ,overview ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The DIII-D tokamak has elucidated crucial physics and developed projectable solutions for ITER and fusion power plants in the key areas of core performance, boundary heat and particle transport, and integrated scenario operation, with closing the core-edge integration knowledge gap being the overarching mission. New experimental validation of high-fidelity, multi-channel, non-linear gyrokinetic turbulent transport models for ITER provides strong confidence it will achieve Q ⩾ 10 operation. Experiments identify options for easing H-mode access in hydrogen, and give new insight into the isotopic dependence of transport and confinement. Analysis of 2,1 islands in unoptimized low-torque IBS demonstration discharges suggests their onset time occurs randomly in the constant β phase, most often triggered by non-linear 3-wave coupling, thus identifying an NTM seeding mechanism to avoid. Pure deuterium SPI for disruption mitigation is shown to provide favorable slow cooling, but poor core assimilation, suggesting paths for improved SPI on ITER. At the boundary, measured neutral density and ionization source fluxes are strongly poloidally asymmetric, implying a 2D treatment is needed to model pedestal fuelling. Detailed measurements of pedestal and SOL quantities and impurity charge state radiation in detached divertors has validated edge fluid modelling and new self-consistent ‘pedestal-to-divertor’ integrated modeling that can be used to optimize reactors. New feedback adaptive ELM control minimizes confinement reduction, and RMP ELM suppression with sustained high core performance was obtained for the first time with the outer strike point in a W-coated, compact and unpumped small-angle slot divertor. Advances have been made in integrated operational scenarios for ITER and power plants. Wide pedestal intrinsically ELM-free QH-modes are produced with more reactor-relevant conditions, Low torque IBS with W-equivalent radiators can exhibit predator-prey oscillations in T _e and radiation which need control. High- β _P scenarios with q _min > 2, q _95 –7.9, β _N > 4, β _T –3.3% and H _98y2 > 1.5 are sustained with high density ( $\bar n$ = 7E19 m ^−3 , f _G –1) for 6 τ _E , improving confidence in steady-state tokamak reactors. Diverted NT plasmas achieve high core performance with a non-ELMing edge, offering a possible highly attractive core-edge integration solution for reactors.
- Published
- 2024
- Full Text
- View/download PDF
9. Understanding the process of meanings, materials, and competencies in adoption of mobile banking.
- Author
-
Muhammad Naeem, Wilson Ozuem, Kerry E. Howell, and Silvia Ranfagni
- Published
- 2022
- Full Text
- View/download PDF
10. Student Attitudes Contribute to the Effectiveness of a Genomics CURE
- Author
-
David Lopatto, Anne G. Rosenwald, Rebecca C. Burgess, Catherine Silver Key, Melanie Van Stry, Matthew Wawersik, Justin R. DiAngelo, Amy T. Hark, Matthew Skerritt, Anna K. Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, James E. J. Bedard, Indrani Bose, John M. Braverman, Martin G. Burg, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A. Escobar, Michael Foulk, Thomas Giarla, Rivka L. Glaser, Anya L. Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Carina E. Howell, Jennifer Jemc, Christopher J. Jones, Lisa Kadlec, Jacob D. Kagey, Kimberly L. Keller, Jennifer Kennell, Adam J. Kleinschmit, Melissa Kleinschmit, Nighat P. Kokan, Olga Ruiz Kopp, Meg M. Laakso, Judith Leatherman, Lindsey J. Long, Mollie Manier, Juan C. Martinez-Cruzado, Luis F. Matos, Amie Jo McClellan, Gerard McNeil, Evan Merkhofer, Vida Mingo, Hemlata Mistry, Elizabeth Mitchell, Nathan T. Mortimer, Jennifer Leigh Myka, Alexis Nagengast, Paul Overvoorde, Don Paetkau, Leocadia Paliulis, Susan Parrish, Stephanie Toering Peters, Mary Lai Preuss, James V. Price, Nicholas A. Pullen, Catherine Reinke, Dennis Revie, Srebrenka Robic, Jennifer A. Roecklein-Canfield, Michael R. Rubin, Takrima Sadikot, Jamie Siders Sanford, Maria Santisteban, Kenneth Saville, Stephanie Schroeder, Christopher D. Shaffer, Karim A. Sharif, Diane E. Sklensky, Chiyedza Small, Sheryl Smith, Rebecca Spokony, Aparna Sreenivasan, Joyce Stamm, Rachel Sterne-Marr, Katherine C. Teeter, Justin Thackeray, Jeffrey S. Thompson, Norma Velazquez-Ulloa, Cindy Wolfe, James Youngblom, Brian Yowler, Leming Zhou, Janie Brennan, Jeremy Buhler, Wilson Leung, Sarah C. R. Elgin, and Laura K. Reed
- Subjects
active learning ,bioinformatics ,CUREs ,genomics ,undergraduate education ,Special aspects of education ,LC8-6691 ,Biology (General) ,QH301-705.5 - Abstract
ABSTRACT The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits. While the GEP CURE produces positive outcomes overall, the students with more positive attitudes toward science, particularly with respect to epistemic beliefs, showed greater gains. The findings indicate the importance of a student’s epistemic beliefs to achieving positive learning outcomes.
- Published
- 2022
- Full Text
- View/download PDF
11. Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer
- Author
-
Ling Wang, Culton R. Hensley, Mary E. Howell, and Shunbin Ning
- Subjects
p62 ,LIHC ,SRX1 ,TXNRD1 ,algorithm analysis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Liver hepatocellular carcinoma (LIHC) is the major form of liver cancer that is the fourth most common cause of cancer death worldwide. It has been reported that the multifunctional protein p62 (also known as SQSTM1) plays a cancer-promoting role in LIHC, but the detailed mechanisms underlying p62 interaction with LIHC remains unclear. To gain a comprehensive understanding of p62 interaction with LIHC in clinical settings, we performed bioinformatic analyses using various online algorithms derived from high throughput profiling. Our results indicate that p62 expression is significantly upregulated, partially due to its promoter demethylation, rather than p62 gene mutation, in LIHC. Mutation of TP53, CTNNB1, or ALB significantly correlates with, and mutation of AXIN1 reversely correlates with, the p62 expression level. Its upregulation occurs as early as liver cirrhosis, and go through all stages of the carcinogenesis. HCV infection makes a significant contribution to p62 upregulation in LIHC. We further identified p62-associated molecular signatures in LIHC, including many genes that are involved in antioxidant stress and metabolism, such as SRX1 and TXNRD1. Regarding to the clinical outcome, p62 expression level reversely correlates with the survival of LIHC patients (p
- Published
- 2022
- Full Text
- View/download PDF
12. Identifying factors linked with persistence of reintroduced populations: Lessons learned from 25 years of amphibian translocations
- Author
-
Blake R. Hossack, Paige E. Howell, Audrey K. Owens, Cassidi Cobos, Caren S. Goldberg, David Hall, Shaula Hedwall, Susan K. MacVean, Magnus MacCaffery, A. Hunter McCall, Cody D. Mosley, Emily B. Oja, James C. Rorabaugh, Brent H. Sigafus, and Michael J. Sredl
- Subjects
Captive breeding ,Colonization ,EDNA ,Extinction ,Recovery ,Restoration ,Ecology ,QH540-549.5 - Abstract
Conservation translocations are increasingly used to help recover imperiled species. However, success of establishing populations remains low, especially for amphibians. Identifying factors associated with translocation success can help increase efficiency and efficacy of recovery efforts. Since the 1990s, several captive and semi-captive facilities have produced Chiricahua Leopard Frogs (Rana chiricahuensis) to establish or augment wild populations in Arizona and New Mexico, USA. During this same time, personnel associated with several programs surveyed translocation and non-translocation sites for presence of amphibians. We used 25 years (1995–2019) of survey and translocation data for the federally threatened Chiricahua Leopard Frog to identify factors linked with population persistence. Our dataset included approximately 40,642 egg masses or animals translocated in 314 events to 115 distinct sites and > 5800 visual encounter surveys from 641 sites; 120 of these sites were also surveyed with environmental DNA methods in 2018. We used a hierarchical dynamic occupancy model that accounted for imperfect detection to identify patch- and landscape-level attributes associated with site occupancy, and then used predictions from that model to evaluate factors associated with population persistence at translocation sites. Across all sites, extinction probability for Chiricahua Leopard Frogs was higher in lotic (stream) than lentic (pond) habitats and when Western Tiger Salamanders (Ambystoma mavortium) were present. Restoration of sites specifically for frog conservation reduced extinction probability. Colonization of unoccupied sites increased moderately with increasing numbers of translocation sites within 2 km, indicating a benefit of translocation efforts beyond sites where frogs were stocked. At translocation sites, persistence was greater in lentic than lotic habitats and was negatively correlated with the proportion of years tiger salamanders were present. Increasing numbers of translocation events, especially of late-stage larvae, increased persistence. There was little difference in population persistence based on whether stock was from captive, semi-captive, or wild sources, but translocations during the dry season (JanuaryJuly) succeeded more than those after the typical arrival of summer rains (AugustDecember). Based on the number of years translocation sites were predicted to be occupied, 2 or more translocations produced, on average, a > 4-yr increase in predicted occupancy compared to sites without translocations. While translocations have increased the number of populations across the landscape, continued management of water availability and threats such as invasive predators and disease remain critical to recovery of the Chiricahua Leopard Frog.
- Published
- 2022
- Full Text
- View/download PDF
13. Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility
- Author
-
Jamie W. Robinson, Richard M. Martin, Spiridon Tsavachidis, Amy E. Howell, Caroline L. Relton, Georgina N. Armstrong, Melissa Bondy, Jie Zheng, and Kathreena M. Kurian
- Subjects
Medicine ,Science - Abstract
Abstract Genome-wide association studies (GWAS) have discovered 27 loci associated with glioma risk. Whether these loci are causally implicated in glioma risk, and how risk differs across tissues, has yet to be systematically explored. We integrated multi-tissue expression quantitative trait loci (eQTLs) and glioma GWAS data using a combined Mendelian randomisation (MR) and colocalisation approach. We investigated how genetically predicted gene expression affects risk across tissue type (brain, estimated effective n = 1194 and whole blood, n = 31,684) and glioma subtype (all glioma (7400 cases, 8257 controls) glioblastoma (GBM, 3112 cases) and non-GBM gliomas (2411 cases)). We also leveraged tissue-specific eQTLs collected from 13 brain tissues (n = 114 to 209). The MR and colocalisation results suggested that genetically predicted increased gene expression of 12 genes were associated with glioma, GBM and/or non-GBM risk, three of which are novel glioma susceptibility genes (RETREG2/FAM134A, FAM178B and MVB12B/FAM125B). The effect of gene expression appears to be relatively consistent across glioma subtype diagnoses. Examining how risk differed across 13 brain tissues highlighted five candidate tissues (cerebellum, cortex, and the putamen, nucleus accumbens and caudate basal ganglia) and four previously implicated genes (JAK1, STMN3, PICK1 and EGFR). These analyses identified robust causal evidence for 12 genes and glioma risk, three of which are novel. The correlation of MR estimates in brain and blood are consistently low which suggested that tissue specificity needs to be carefully considered for glioma. Our results have implicated genes yet to be associated with glioma susceptibility and provided insight into putatively causal pathways for glioma risk.
- Published
- 2021
- Full Text
- View/download PDF
14. Service quality in multichannel fashion retailing: an exploratory study.
- Author
-
Elena Patten, Wilson Ozuem, and Kerry E. Howell
- Published
- 2020
- Full Text
- View/download PDF
15. Distance sampling and spatial capture-recapture for estimating density of Northern Bobwhite.
- Author
-
Victoria Nolan, Nathan Wilhite, Paige E. Howell, Richard B. Chandler, Dallas Ingram, John M. Yeiser, Chris Scott, and James A. Martin
- Published
- 2023
- Full Text
- View/download PDF
16. Correction to: Understanding the process of meanings, materials, and competencies in adoption of mobile banking.
- Author
-
Muhammad Naeem, Wilson Ozuem, Kerry E. Howell, and Silvia Ranfagni
- Published
- 2023
- Full Text
- View/download PDF
17. A meta‐analysis of toxicities related to hydroxycarbamide dosing strategies
- Author
-
Joacy G. Mathias, Vikki G. Nolan, Meghan Meadows‐Taylor, L. Ashley Robinson, Kristen E. Howell, James G. Gurney, Jane S. Hankins, Winfred C. Wang, Jeremie H. Estepp, and Matthew P. Smeltzer
- Subjects
dosing ,hydroxycarbamide ,meta‐analysis ,sickle cell disease ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Due to fear of short‐term toxicities, there is nonconsensus of hydroxycarbamide dosing strategy (escalated vs fixed‐dosing methods), which contributes to its suboptimal use. We performed a meta‐analysis to summarize the incidence rates of toxicities associated with both dosing methods. Summarized incidence rates could not be statistically compared between dosing methods due to sparse data. Summarized neutropenia and thrombocytopenia incidence rates were slightly higher when using escalated dosing than with fixed. Summarized reticulocytopenia was comparable. Summarized hepatic and renal toxicities’ incidence rates were slightly higher when using fixed doses than with escalated. We recommend diligent and transparent reporting of toxicities.
- Published
- 2020
- Full Text
- View/download PDF
18. Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study
- Author
-
A. E. Howell, J. W. Robinson, R. E. Wootton, A. McAleenan, S. Tsavachidis, Q. T. Ostrom, M. Bondy, G. Armstrong, C. Relton, P. Haycock, R. M. Martin, J. Zheng, and K. M. Kurian
- Subjects
Mendelian randomization ,Glioma ,Risk factor ,Systematic search ,Causal inference ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed whether associations of 36 reported glioma risk factors showed evidence of a causal relationship. Methods We performed a systematic search of MEDLINE from inception to October 2018 to identify candidate risk factors and conducted a meta-analysis of two glioma genome-wide association studies (5739 cases and 5501 controls) to form our exposure and outcome datasets. MR analyses were performed using genetic variants to proxy for candidate risk factors. We investigated whether risk factors differed by subtype diagnosis (either glioblastoma (n = 3112) or non-glioblastoma (n = 2411)). MR estimates for each risk factor were determined using multiplicative random effects inverse-variance weighting (IVW). Sensitivity analyses investigated potential pleiotropy using MR-Egger regression, the weighted median estimator, and the mode-based estimator. To increase power, trait-specific polygenic risk scores were used to test the association of a genetically predicated increase in each risk factor with glioma onset. Results Our systematic search identified 36 risk factors that could be proxied using genetic variants. Using MR, we found evidence that four genetically predicted traits increased risk of glioma, glioblastoma or non-glioblastoma: longer leukocyte telomere length, liability to allergic disease, increased alcohol consumption and liability to childhood extreme obesity (> 3 standard deviations from the mean). Two traits decreased risk of non-glioblastoma cancers: increased low-density lipoprotein cholesterol (LDLc) and triglyceride levels. Our findings were similar across sensitivity analyses that made allowance for pleiotropy (genetic confounding). Conclusions Our comprehensive investigation provides evidence of a causal link between both genetically predicted leukocyte telomere length, allergic disease, alcohol consumption, childhood extreme obesity, and LDLc and triglyceride levels, and glioma. The findings from our study warrant further research to uncover mechanisms that implicate these traits in glioma onset.
- Published
- 2020
- Full Text
- View/download PDF
19. Identifying barriers to evidence-based care for sickle cell disease: results from the Sickle Cell Disease Implementation Consortium cross-sectional survey of healthcare providers in the USA
- Author
-
Robert Gibson, Jane S Hankins, Matthew P Smeltzer, Kristen E Howell, Marsha Treadwell, Liliana Preiss, Allison A King, Jeffrey A Glassberg, Paula Tanabe, Sherif M Badawy, Lisa DiMartino, Julie Kanter, and Lisa M Klesges
- Subjects
Medicine - Abstract
Objectives Sickle cell disease (SCD) leads to chronic and acute complications that require specialised care to manage symptoms and optimise clinical results. The National Heart Lung and Blood Institute (NHLBI) evidence-based guidelines assist providers in caring for individuals with SCD, but adoption of these guidelines by providers has not been optimal. The objective of this study was to identify barriers to treating individuals with SCD.Methods The SCD Implementation Consortium aimed to investigate the perception and level of comfort of providers regarding evidence-based care by surveying providers in the regions of six clinical centres across the USA, focusing on non-emergency care from the providers’ perspective.Results Respondents included 105 providers delivering clinical care for individuals with SCD. Areas of practice were most frequently paediatrics (24%) or haematology/SCD specialist (24%). The majority (77%) reported that they were comfortable managing acute pain episodes while 63% expressed comfort with managing chronic pain. Haematologists and SCD specialists showed higher comfort levels prescribing opioids (100% vs 67%, p=0.004) and managing care with hydroxyurea (90% vs 51%, p=0.005) compared with non-haematology providers. Approximately 33% of providers were unaware of the 2014 NHLBI guidelines. Nearly 63% of providers felt patients’ medical needs were addressed while only 22% felt their mental health needs were met.Conclusions A substantial number of providers did not know about NHLBI’s SCD care guidelines. Barriers to providing care for patients with SCD were influenced by providers’ specialty, training and practice setting. Increasing provider knowledge could improve hydroxyurea utilisation, pain management and mental health support.
- Published
- 2021
- Full Text
- View/download PDF
20. Happy Trees in a Black Box: Elevated Escapism as Comfort Television in The Joy of Painting with Bob Ross
- Author
-
Charlotte E. Howell, Charlotte E. Howell, Joyce B. Howell, Charlotte E. Howell, Charlotte E. Howell, and Joyce B. Howell
- Abstract
The Journal of Cinema and Media Studies: vol. 62, no. 5, (dlps) 18261332.0062.503, http://hdl.handle.net/2027/spo.18261332.0062.503, This work is protected by copyright and may be linked to without seeking permission. Permission must be received for subsequent distribution in print or electronically. Please contact mpub-help@umich.edu for more information.
- Published
- 2023
21. Consumption and communication perspectives of IT in a developing economy.
- Author
-
Wilson Ozuem, Kerry E. Howell, and Geoff Lancaster
- Published
- 2019
- Full Text
- View/download PDF
22. Edge density affects demography of an exploited grassland bird
- Author
-
Paige E. Howell, Theron M. Terhune, and James A. Martin
- Subjects
density ,edge density ,fragmentation ,known‐fate ,Northern Bobwhite ,productivity ,Ecology ,QH540-549.5 - Abstract
Abstract Humans modify landscapes for a variety of reasons including agriculture, urbanization, and to facilitate recreation. Landscape modifications can lead to complete loss of existing cover types and/or fragmentation of remaining cover types. Grasslands are one of the ecosystems most heavily impacted by human modifications; however, for many species, an understanding of how fragmentation affects population parameters is lacking. We investigated the influence of landscape fragmentation on survival, reproduction, and density using the northern bobwhite (Colinus virginianus), a facultative grassland species, as our case study. We experimentally manipulated the level of edge density (none, low, and high) of bobwhite management units and estimated seasonal survival, productivity, and autumn densities. Winter survival was lower in edge density treatments, relative to the control. An increase in migratory raptor density during the winter, along with a decrease in thermal refugia, may be contributing to lower winter survival in edge density treatments. Fecundity was higher in the edge density treatments, relative to the control, and was negatively related to winter survival. Similarly, breeding season survival was higher in more fragmented sites. This indicated a density‐dependent relationship, where lower bird densities at the beginning of the breeding season possibly led to greater resource availability, and thus survival and productivity, of the birds that remained. However, a density‐dependent response in breeding season survival and productivity was not enough to offset the negative impact of edges in the low edge density sites. Consequently, autumn density was lower relative to both control and high edge density treatments. Our study demonstrates the importance of capturing the entire life cycle when exploring the relationship between landscape pattern and population parameters.
- Published
- 2021
- Full Text
- View/download PDF
23. Retrospective study of inpatient diabetes management service, length of stay and 30-day readmission rate of patients with diabetes at a community hospital
- Author
-
Samantha R. Mandel, Susan Langan, Nestoras Nicolas Mathioudakis, Aniket R. Sidhaye, Holly Bashura, Jun Y. Bie, Periwinkle Mackay, Cynthia Tucker, Andrew P. Demidowich, William F. Simonds, Smita Jha, Ifechukwude Ebenuwa, Melinda Kantsiper, Eric E. Howell, Patricia Wachter, Sherita Hill Golden, and Mihail Zilbermint
- Subjects
Inpatient diabetes management ,length of stay ,readmissions ,cost savings ,diabetes ,Internal medicine ,RC31-1245 - Abstract
Background: Hospitalized patients with diabetes are at risk of complications and longer length of stay (LOS). Inpatient Diabetes Management Services (IDMS) are known to be beneficial; however, their impact on patient care measures in community, non-teaching hospitals, is unknown. Objectives: To evaluate whether co-managing patients with diabetes by the IDMS team reduces LOS and 30-day readmission rate (30DR). Methods: This retrospective quality improvement cohort study analyzed LOS and 30DR among patients with diabetes admitted to a community hospital. The IDMS medical team consisted of an endocrinologist, nurse practitioner, and diabetes educator. The comparison group consisted of hospitalized patients with diabetes under standard care of attending physicians (mostly internal medicine-trained hospitalists). The relationship between study groups and outcome variables was assessed using Generalized Estimating Equation models. Results: 4,654 patients with diabetes (70.8 ± 0.2 years old) were admitted between January 2016 and May 2017. The IDMS team co-managed 18.3% of patients, mostly with higher severity of illness scores (p
- Published
- 2019
- Full Text
- View/download PDF
24. Impact of Heavy-Ion Range on Single-Event Effects in Silicon Carbide Power Junction Barrier Schottky Diodes
- Author
-
Arijit Sengupta, Dennis R. Ball, Arthur F. Witulski, En Xia Zhang, Ronald D. Schrimpf, Kenneth F. Galloway, Robert A. Reed, Michael L. Alles, Michael W. McCurdy, Andrew L. Sternberg, Robert A. Johnson, Mick E. Howell, Jason M. Osheroff, and John M. Hutson
- Subjects
Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,Electrical and Electronic Engineering - Published
- 2023
25. Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort [version 1; peer review: 1 approved, 2 approved with reservations]
- Author
-
Tamsin H. Sharp, Nancy S. McBride, Amy E. Howell, C. John Evans, Derek K. Jones, Gavin Perry, Stavros I. Dimitriadis, Thomas M. Lancaster, Luisa Zuccolo, Caroline Relton, Sarah M. Matthews, Thomas Breeze, Anthony S. David, Mark Drakesmith, David E. J. Linden, Tomas Paus, and Esther Walton
- Subjects
Medicine ,Science - Abstract
Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Study of Parents and Children, a prospective multigenerational pregnancy and birth cohort based in the United Kingdom. Brain imaging data were acquired when offspring were between 18 and 24 years of age, and included acquisition of structural, functional and magnetization transfer magnetic resonance, diffusion tensor, and magnetoencephalography imaging. This resource provides a unique opportunity to combine neuroimaging data with extensive phenotypic and genotypic measures from participants, their mothers, and fathers.
- Published
- 2020
- Full Text
- View/download PDF
26. Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience
- Author
-
David Lopatto, Anne G. Rosenwald, Justin R. DiAngelo, Amy T. Hark, Matthew Skerritt, Matthew Wawersik, Anna K. Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, Christopher Bazinet, James E. J. Bedard, Indrani Bose, John M. Braverman, Martin G. Burg, Rebecca C. Burgess, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A. Escobar, Michael Foulk, Emily Furbee, Thomas Giarla, Rivka L. Glaser, Anya L. Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Carina E. Howell, Jennifer Jemc, M. Logan Johnson, Christopher J. Jones, Lisa Kadlec, Jacob D. Kagey, Kimberly L. Keller, Jennifer Kennell, S. Catherine Silver Key, Adam J. Kleinschmit, Melissa Kleinschmit, Nighat P. Kokan, Olga Ruiz Kopp, Meg M. Laakso, Judith Leatherman, Lindsey J. Long, Mollie Manier, Juan C. Martinez-Cruzado, Luis F. Matos, Amie Jo McClellan, Gerard McNeil, Evan Merkhofer, Vida Mingo, Hemlata Mistry, Elizabeth Mitchell, Nathan T. Mortimer, Debaditya Mukhopadhyay, Jennifer Leigh Myka, Alexis Nagengast, Paul Overvoorde, Don Paetkau, Leocadia Paliulis, Susan Parrish, Mary Lai Preuss, James V. Price, Nicholas A. Pullen, Catherine Reinke, Dennis Revie, Srebrenka Robic, Jennifer A. Roecklein-Canfield, Michael R. Rubin, Takrima Sadikot, Jamie Siders Sanford, Maria Santisteban, Kenneth Saville, Stephanie Schroeder, Christopher D. Shaffer, Karim A. Sharif, Diane E. Sklensky, Chiyedza Small, Mary Smith, Sheryl Smith, Rebecca Spokony, Aparna Sreenivasan, Joyce Stamm, Rachel Sterne-Marr, Katherine C. Teeter, Justin Thackeray, Jeffrey S. Thompson, Stephanie Toering Peters, Melanie Van Stry, Norma Velazquez-Ulloa, Cindy Wolfe, James Youngblom, Brian Yowler, Leming Zhou, Janie Brennan, Jeremy Buhler, Wilson Leung, Laura K. Reed, and Sarah C. R. Elgin
- Subjects
Special aspects of education ,LC8-6691 ,Biology (General) ,QH301-705.5 - Abstract
A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) is a consortium of faculty who engage their students in a genomics Course-Based Undergraduate Research Experience (CURE). Students participate in genome annotation, generating gene models using multiple lines of experimental evidence. Our observations suggested that the students’ learning experience is continuous and recursive, frequently beginning with frustration but eventually leading to success as they come up with defendable gene models. In order to explore our “formative frustration” hypothesis, we gathered data from faculty via a survey, and from students via both a general survey and a set of student focus groups. Upon analyzing these data, we found that all three datasets mentioned frustration and struggle, as well as learning and better understanding of the scientific process. Bioinformatics projects are particularly well suited to the process of iteration and refinement because iterations can be performed quickly and are inexpensive in both time and money. Based on these findings, we suggest that a dynamic of “formative frustration” is an important aspect for a successful CURE.
- Published
- 2020
- Full Text
- View/download PDF
27. The development of a convolutional neural network for the automatic detection of Northern Bobwhite Colinus virginianus covey calls
- Author
-
Victoria Nolan, Chris Scott, John M. Yeiser, Nathan Wilhite, Paige E. Howell, Dallas Ingram, and James A. Martin
- Subjects
Ecology ,Computers in Earth Sciences ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Published
- 2022
28. Corporate Governance in Africa: Assessing Implementation and Ethical Perspectives
- Author
-
Kerry E. Howell, M. Karim Sorour, Kerry E. Howell, M. Karim Sorour and Kerry E. Howell, M. Karim Sorour, Kerry E. Howell, M. Karim Sorour
- Published
- 2016
29. Health literacy correlates with abbreviated full‐scale IQ in adolescent and young adults with sickle cell disease
- Author
-
Nidhi Bhatt, Cecelia Calhoun, Jennifer Longoria, Chinonyelum Nwosu, Kristen E. Howell, Taniya Varughese, Guolian Kang, Lisa M. Jacola, Jane S. Hankins, and Allison King
- Subjects
Oncology ,Pediatrics, Perinatology and Child Health ,Hematology - Published
- 2023
30. Understanding technologically-induced customer services in the Nigerian banking sector: the internet as a post-modern phenomenon.
- Author
-
Wilson Ozuem, Kerry E. Howell, and Geoff Lancaster
- Published
- 2016
- Full Text
- View/download PDF
31. Capture of Spawning Brook Trout by Electrofishing Does Not Impair Embryo Survival
- Author
-
Bradley E. Howell, Erin M. C. Stewart, Vince R. Frasca, Chris C. Wilson, and Graham D. Raby
- Subjects
Ecology ,Management, Monitoring, Policy and Law ,Aquatic Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
32. Revisiting hylomorphism: What can it contribute to our understanding of information systems?
- Author
-
Lauren A. Bennett, Janet Toland, Bronwyn E. Howell, and Mary Tate
- Published
- 2019
33. Is C-reactive protein the single most useful predictor of difficult laparoscopic cholecystectomy or its conversion? A pilot study
- Author
-
Kam Wa Jessica Mok, Yan Li Goh, Laura E Howell, and Ravindra S Date
- Subjects
C-reactive protein ,difficult dissection ,laparoscopic cholecystectomy ,predicting conversion ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Both converted and difficult laparoscopic cholecystectomies (LC) have impact on operating time and training of juniors. The aim of this study is to evaluate parameters that predict difficult LC or conversion (C), and find predictive values for different cut-off points of C-reactive protein (CRP) for conversion. Materials and Methods: A retrospective cohort study of cholecystectomies performed from January 2011 to December 2012 at NHS trust was undertaken. Association of intra-operative difficulties or conversion with the following factors was studied: Age, gender, CRP, white blood cell count (WBC), history of pancreatitis, and endoscopic retrograde cholangiopancreatography (ERCP). Results: Two hundred and ninety one patients were analysed (222 laparoscopic, 45 difficult LC and 24 C). Only 141 patients had a recorded CRP. Median CRP was highest for patients who were converted (286.20) compared to those who had difficult LC (67.40) or LC (7.05). Those patients who did not have preoperative CRP (8/150, 5.3%) had less chance of conversion than those who had CRP (16/141, 11.34%) (P = 0.063). Patients with CRP of ≤220 (3/91, 3.2%) had significantly less chance of conversion than those with CRP >220 (13/21, 61.9%) (P < 0.001). High preoperative CRP, WBC count and ERCP, were predictors of conversion. These factors were only marginally better than CRP alone in predicting conversion. Conclusion: CRP can be a strong predictor of conversion of LC. Further validation of the results is needed.
- Published
- 2016
- Full Text
- View/download PDF
34. 'The American Outlaws Are Our People': Fox Sports and the Branded Ambivalence of an American Soccer Fan at the 2019 FIFA Women’s World Cup
- Author
-
Charlotte E. Howell
- Subjects
Cultural Studies ,Visual Arts and Performing Arts ,Gender studies ,Participant observation ,Sociology ,Ambivalence ,human activities - Abstract
Drawing on fan studies, sports media studies, media industries studies, and participant observation of the American Outlaws, this essay analyzes specific aspects of the 2019 FIFA Women’s World Cup as televised by Fox Sports in the wider context of soccer’s evolving place within the American sports media marketplace. American media companies have increasingly positioned soccer as an upscale sport in the U.S. In addition to representing an affluent and cosmopolitan taste culture, the representation of the American Outlaws as part of Fox Sports’ programming and branding flattened the frictions of class, national identity, politics, and race that shaped American soccer discourse in the summer of 2019. This essay explores this flattening and the underlying tensions between televising a tournament based in American national identity that allows for a more mass audience appeal and the more niche-based framing of soccer—including the progressive politics of women’s soccer—in U.S. sports media.
- Published
- 2021
35. Capturing the Rest: Inpatient Mammography for Nonadherent Hospitalized Women
- Author
-
Waseem Khaliq, Colleen Siferd, Melinda E. Kantsiper, Scott M. Wright, Lisa K. Jacobs, and Eric E. Howell
- Subjects
Inpatients ,medicine.medical_specialty ,Framingham Risk Score ,medicine.diagnostic_test ,Epidemiology ,business.industry ,Public Health, Environmental and Occupational Health ,MEDLINE ,Breast Neoplasms ,Middle Aged ,medicine.disease ,Breast cancer screening ,Breast cancer ,Family medicine ,Humans ,Medicine ,Mammography ,Population study ,Female ,Prospective Studies ,Family history ,Trial registration ,business ,Early Detection of Cancer - Abstract
Introduction More than a third of hospitalized women are overdue or nonadherent to breast cancer screening guidelines, and almost a third of them are also at high risk for developing breast cancer. The purpose of this study is to evaluate the feasibility of coordinating inpatient breast cancer screening mammography for these women before their discharge from the hospital. Methods A prospective intervention study was conducted among 101 nonadherent women aged 50–74 years who were hospitalized to a general medicine service. Sociodemographic, reproductive history, family history of breast cancer, and medical comorbidities data were collected for all patients from January 2015 to October 2016. The data were analyzed in March 2018. Fisher's exact tests and unpaired t-tests were utilized to compare the characteristics of the study population. Results Of the 101 women enrolled who were nonadherent to breast cancer screening recommendations, their mean age was 59.3 (SD=6) years, the mean 5-year Gail risk score was 1.63 (SD=0.69), and 29% of the women were African American. Almost 80% (n=79) underwent inpatient screening mammography. All women who underwent screening mammography during their inpatient stay were extremely satisfied with the experience. The convenience of having screening mammography while hospitalized was reported to be a major facilitator of completing the overdue screening. All nurses (100%) taking care of these women believed that this practice should become part of the standard of care, and most hospitalist physicians (66%) agreed that this practice is feasible. Conclusions This study shows that it is possible to coordinate mammography for hospitalized women who were overdue for screening and at high risk for developing breast cancer. Trial registration This study is registered at www.clinicaltrials.gov NCT04164251.
- Published
- 2021
36. Visualizing the Invisible: A Guide to Designing, Printing, and Incorporating Dynamic 3D Molecular Models to Teach Structure–Function Relationships
- Author
-
Michelle E. Howell, Karin van Dijk, Christine S. Booth, Tomáš Helikar, Brian A. Couch, and Rebecca L. Roston
- Subjects
Special aspects of education ,LC8-6691 ,Biology (General) ,QH301-705.5 - Abstract
3D printing represents an emerging technology with significant potential to advance life-science education by allowing students to directly explore the relationship between macromolecular structure and function. In this article and supplemental video guide, we describe our development of a model-based instructional module on DNA supercoiling and outline practical tips for implementing models in undergraduate classrooms. We also present a procedure to design and print 3D dynamic models for classroom use. Furthermore, we describe repositories of 3D biomolecule files to make using models accessible and cost-effective.
- Published
- 2018
- Full Text
- View/download PDF
37. A touch morewith Megan Rapinoe and Sue Bird: authenticity, intimacy and women’s sports celebrity on Instagram live
- Author
-
Charlotte E. Howell
- Subjects
Cultural Studies ,2019-20 coronavirus outbreak ,Precarity ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Women's sports ,Media studies ,Sociology ,Persona ,Superstar - Abstract
Instagram Live has become a useful tool for maintaining celebrity and continuing to generate engagement, one that many celebrities turned to during COVID-19 shut-downs. Among them, Sue Bird and Megan Rapinoe, the women's sports power-couple, used Instagram Live to create a weekly talk-show that would eventually be titled A Touch More. The Instagram Live platform provided the unpredictability of liveness and enabled Bird and Rapinoe to perform intimacy and authenticity as part of their celebrity persona maintenance during a time of increased precarity for their sports and thus their main avenue for fame. This article analyzes how Instagram Live - in relation to Instagram and Instagram Stories - operates as a locus of celebrity performance of authenticity and intimacy with A Touch More as the case study. Further, by exploring the construction of Bird and Rapinoe's individual and coupled celebrity personas as fundamentally connected to the gendered precarity of their sports, I argue that even with their superstar status, Bird and Rapinoe's cultivated intimacy in A Touch More was, in essence, a market necessity.
- Published
- 2021
38. Feasibility of Fitbit Use in Adolescent Survivors of Pediatric Cancer: Who Consistently Uses It and for How Long?
- Author
-
Rebecca Williamson Lewis, Kristen E. Howell, Karen E. Effinger, Lillian R. Meacham, Karen Wasilewski-Masker, Ann Mertens, and Jordan Gilleland Marchak
- Subjects
Oncology ,Pediatrics, Perinatology and Child Health - Published
- 2022
39. Implementation of the I-PASS handoff program in diverse clinical environments: A multicenter prospective effectiveness implementation study
- Author
-
Amy J, Starmer, Nancy D, Spector, Jennifer K, O'Toole, Zia, Bismilla, Sharon, Calaman, Maria-Lucia, Campos, Maitreya, Coffey, Lauren A, Destino, Jennifer L, Everhart, Jenna, Goldstein, Dionne A, Graham, Jennifer H, Hepps, Eric E, Howell, Nicholas, Kuzma, Greg, Maynard, Patrice, Melvin, Shilpa J, Patel, Alina, Popa, Glenn, Rosenbluth, Jeffrey L, Schnipper, Theodore C, Sectish, Rajendu, Srivastava, Daniel C, West, Clifton E, Yu, and Christopher P, Landrigan
- Subjects
Adult ,Leadership and Management ,Health Policy ,Communication ,Patient Handoff ,Internship and Residency ,General Medicine ,Assessment and Diagnosis ,Internal Medicine ,Humans ,Fundamentals and skills ,Prospective Studies ,Child ,Care Planning - Abstract
Handoff miscommunications are a leading source of medical errors. Harmful medical errors decreased in pediatric academic hospitals following implementation of the I-PASS handoff improvement program. However, implementation across specialties has not been assessed.To determine if I-PASS implementation across diverse settings would be associated with improvements in patient safety and communication.Prospective Type 2 Hybrid effectiveness implementation study.Residents from diverse specialties across 32 hospitals (12 community, 20 academic).External teams provided longitudinal coaching over 18 months to facilitate implementation of an enhanced I-PASS program and monthly metric reviews.Systematic surveillance surveys assessed rates of resident-reported adverse events. Validated direct observation tools measured verbal and written handoff quality.2735 resident physicians and 760 faculty champions from multiple specialties (16 internal medicine, 13 pediatric, 3 other) participated. 1942 error surveillance reports were collected. Major and minor handoff-related reported adverse events decreased 47% following implementation, from 1.7 to 0.9 major events/person-year (p .05) and 17.5 to 9.3 minor events/person-year (p .001). Implementation was associated with increased inclusion of all five key handoff data elements in verbal (20% vs. 66%, p .001, n = 4812) and written (10% vs. 74%, p .001, n = 1787) handoffs, as well as increased frequency of handoffs with high quality verbal (39% vs. 81% p .001) and written (29% vs. 78%, p .001) patient summaries, verbal (29% vs. 78%, p .001) and written (24% vs. 73%, p .001) contingency plans, and verbal receiver syntheses (31% vs. 83%, p .001). Improvement was similar across provider types (adult vs. pediatric) and settings (community vs. academic).
- Published
- 2022
40. What do telecommunications policy academics have to fear from GPT-3?
- Author
-
Bronwyn E. Howell and Petrus H. Potgieter
- Subjects
Economics and Econometrics ,Communication ,Library and Information Sciences ,Management, Monitoring, Policy and Law ,Information Systems ,Management Information Systems - Published
- 2023
41. Adherence to and Deviation from the Inverse-Square Law of Intensity for Sound and Light
- Author
-
James C. Sanders, Victoria C. Colvin, Soumitra Ganguly, Caroline E. Howell, Ernest Sebastian Lee, Suraj Thapa Magar, and Nicholas A. Johnson
- Subjects
General Physics and Astronomy ,Education - Abstract
The concept of intensity—defined as power output per unit area—is often introduced when discussing sound waves and then revisited (via the Poynting vector) in discussing electromagnetic waves. The discussion is generally limited to isotropic media, with reflections and the resulting interference between waves being considered only in a limited context (such as resonances): the intensity is thus presented as obeying an inverse-square law with respect to the distance between source and observer. However, most actual demonstrations of the intensity–distance relationship (e.g., a speaker placed in a room) take place in an enclosed area, which results in reflections from the room’s boundaries (walls, ceiling, and floor) as well as from other objects in the room (desks, people, etc.). A consequence of these reflections is that the wave is no longer truly propagating in a uniform manner, but instead can interfere with its own reflections. The result of this interference is that the intensity does not ultimately follow an inverse-square law.
- Published
- 2023
42. Dossier: Field Goals—New Directions and Intersections
- Author
-
Samantha N. Sheppard, Katrina Marie Overby, Mia Fischer, Jennifer McClearen, Charlotte E. Howell, and Samantha Close
- Subjects
Field (physics) ,business.industry ,Aerospace engineering ,business ,Psychology - Published
- 2021
43. Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats
- Author
-
Erin McDevitt, Lucie Henein, Anna Crawford, Sandeep Kondakala, Darian Young, Edward Meek, and George E. Howell
- Subjects
Toxicology - Abstract
The overall prevalence of metabolic diseases such as type 2 diabetes (T2D) and associated co-morbidities have increased at an alarming rate in the United States and worldwide. There is a growing body of epidemiological evidence implicating exposure to persistent organic pollutants (POPs), including legacy organochlorine (OC) pesticides and their bioaccumulative metabolites, in the pathogenesis of metabolic diseases. Therefore, the goal of the present study was to determine if exposure to trans-nonachlor, a bioaccumulative OC pesticide contaminant, in concert with high fat diet intake induced metabolic dysfunction. Briefly, male Sprague Dawley rats were exposed to trans-nonachlor (.5 or 5 ppm) in either a low fat (LFD) or high fat diet (HFD) for 16 weeks. At 8 weeks of intake, trans-nonachlor decreased serum triglyceride levels in LFD and HFD fed animals and at 16 weeks compared to LFD fed animals. Interestingly, serum glucose levels were decreased by trans-nonachlor (5 ppm) in LFD fed animals at 16 weeks. Serum free fatty acids were increased by trans-nonachlor exposure (5 ppm) in LFD fed animals at 16 weeks. HFD fed animals displayed signs of hepatic steatosis including elevated liver triglycerides, liver enzymes, and liver lipid peroxidation which were not significantly altered by trans-nonachlor exposure. However, there was a trans-nonachlor mediated increase in expression of fatty acid synthase in livers of LFD fed animals and not HFD fed animals. Thus, the present data indicate exposure to trans-nonachlor in conjunction with LFD or HFD intake produces both diet and exposure dependent effects on lipid and glucose metabolism.
- Published
- 2023
44. A grounded theory analysis of corporate governance in Egyptian banking
- Author
-
Karim Sorour, Mohamed and E. Howell, Kerry
- Published
- 2013
- Full Text
- View/download PDF
45. Knowledge generation and sharing in UK universities: A tale of two cultures?
- Author
-
Kerry E. Howell and Fenio Annansingh
- Published
- 2013
- Full Text
- View/download PDF
46. STAAR: Statistical analysis of aromatic rings.
- Author
-
David D. Jenkins, Jason B. Harris, Elizabeth E. Howell, Robert J. Hinde, and Jérôme Baudry
- Published
- 2013
- Full Text
- View/download PDF
47. OC-0423 Developing quality assurance tests for simultaneous PET-MR imaging for radiotherapy planning
- Author
-
Ross J. Maxwell, Hazel McCallum, J. Wyatt, and E. Howell
- Subjects
Radiation therapy ,Oncology ,business.industry ,medicine.medical_treatment ,medicine ,Radiology, Nuclear Medicine and imaging ,Hematology ,Pet mr imaging ,business ,Nuclear medicine ,Quality assurance - Published
- 2021
48. Audit Committee Quality and Financial Reporting in Deposit Money Banks in Nigeria
- Author
-
T. I. Nwanji, Kerry E. Howell, Ben-Caleb Egbide, Joseph Ugochukwu Madugba, Sainey Faye, and Damilola Felix Eluyela
- Subjects
Finance ,Descriptive statistics ,business.industry ,Accrual ,media_common.quotation_subject ,Corporate governance ,Audit committee ,Development ,General Business, Management and Accounting ,Test (assessment) ,Credibility ,Quality (business) ,Descriptive research ,business ,General Economics, Econometrics and Finance ,media_common - Abstract
The credibility of financial reporting is crucial as it assures the user of its authenticity. In this study, we examined the effect of audit committee quality on the quality of financial reporting of deposit money banks in Nigeria. A descriptive research design was adopted and secondary data sourced from annual accounts of seven deposit money banks for seven years were used to test our hypotheses. The dependent variable in this study is financial reporting quality measured with accrual model. In contrast, the independent variables are the number of members on the audit committee with accounting and finance knowledge, the size of the audit committee, the number of audit committee meetings held in a year and audit committee independence. Descriptive statistics, normality test, a multicollinearity test and regression analysis were used to examine the data. A notable outcome revealed that except for several audit committee meetings held in a given year the other independent variables were found to be insignificant and are not, therefore, determinant of financial reporting quality in deposit money banks in Nigeria. The study concluded that audit committee quality is not a determinant of financial reporting quality in deposit money banks in Nigeria and the study recommends that ability should be paramount for the appointment of members to the audit committee and advises that the audit committee should always be given adequate consideration by management in decision making.
- Published
- 2021
49. Meeting the COVID-19 Deadlines: Choosing Assessments to Determine Eligibility
- Author
-
Staci C. Ballard, Shelley Kathleen Krach, James E. Howell, Suzanne M. Botana, and Tracy L. Paskiewicz
- Subjects
050103 clinical psychology ,2019-20 coronavirus outbreak ,Medical education ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,assessment ,05 social sciences ,COVID-19 ,Articles ,Special education ,Education ,Clinical Psychology ,Identification (information) ,special education policy ,technology ,0501 psychology and cognitive sciences ,Psychology ,General Psychology ,050104 developmental & child psychology ,legal and ethical issues - Abstract
Timely identification of children with disabilities is required by federal special education law (Individuals with Disabilities Education Improvement Act, 20 U.S.C. § 1400, 2004). During COVID-19, school psychologists have been faced with the challenge of completing valid, comprehensive, and diagnostic assessments when traditional methods are not an option. Traditional methods of testing have become nearly impossible due to social distancing requirements; therefore, alternate methods need to be considered. These alternate methods may be unfamiliar to the practitioner and/or lack validation to use with confidence. This study offers a prospective guide to help practitioners make safe and valid test selection and interpretation decisions during a pandemic. Examples of assessments analyzed using this guide are provided for the reader. In addition, a case study is provided as an example.
- Published
- 2021
50. Machine-learning-based hospital discharge predictions can support multidisciplinary rounds and decrease hospital length-of-stay
- Author
-
Arnaud Debraine, Matthew F. Toerper, Jeremiah S. Hinson, Anthony DeAngelo, Erik H. Hoyer, Scott Levin, Eric E Howell, Trushar Dungarani, Sean Barnes, and Eric Hamrock
- Subjects
Patient discharge ,medicine.medical_specialty ,Financial performance ,Receiver operating characteristic ,business.industry ,010102 general mathematics ,Length of hospitalization ,General Medicine ,01 natural sciences ,Patient flow ,03 medical and health sciences ,0302 clinical medicine ,Multidisciplinary approach ,Emergency medicine ,Hospital discharge ,medicine ,030212 general & internal medicine ,0101 mathematics ,business ,Predictive modelling - Abstract
BackgroundPatient flow directly affects quality of care, access and financial performance for hospitals. Multidisciplinary discharge-focused rounds have proven to minimise avoidable delays experienced by patients near discharge. The study objective was to support discharge-focused rounds by implementing a machine-learning-based discharge prediction model using real-time electronic health record (EHR) data. We aimed to evaluate model predictive performance and impact on hospital length-of-stay.MethodsDischarge prediction models were developed from hospitalised patients on four inpatient units between April 2016 and September 2018. Unit-specific models were implemented to make individual patient predictions viewable with the EHR patient track board. Predictive performance was measured prospectively for 12 470 patients (120 780 patient-predictions) across all units. A pre/poststudy design applying interrupted time series methods was used to assess the impact of the discharge prediction model on hospital length-of-stay.ResultsProspective discharge prediction performance ranged in area under the receiver operating characteristic curve from 0.70 to 0.80 for same-day and next-day predictions; sensitivity was between 0.63 and 0.83 and specificity between 0.48 and 0.80. Elapsed length-of-stay, counts of labs and medications, mobility assessments and measures of acute kidney injury were model features providing the most predictive value. Implementing the discharge predictions resulted in a reduction in hospital length-of-stay of over 12 hours on a medicine unit (pConclusionsIncorporating automated patient discharge predictions into multidisciplinary rounds can support decreases in hospital length-of-stay. Variation in execution and impact across inpatient units existed.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.