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As required by Article 29 of the Annotated Model Grant Agreement (Dissemination of Results - Open Access - Visibility of EU Funding) and indicated in CLIC "C&D&E Plan annual update" (D 6.1 see Section 5 "Obligations of CLIC beneficiaries"), the CLIC Consortium has disseminated project results as soon as possible, by disclosing them to the public by appropriate means, including in scientific publications (Art. 29.1). Each beneficiary has granted open access to all peer-reviewed scientific publications uploading them mostly on Zenodo platform (https://zenodo.org/) and other open-access repositories (Art. 29.2). In accordance with Art. 29.4 of the AGA, all scientific publications developed within the project contain the following disclaimer giving information on EU funding: "This research was funded under the framework of Horizon 2020 research project CLIC: Circular models Leveraging Investments in Cultural heritage adaptive reuse. This project has received funding from the European Union's Horizon 2020 research and innovation program under Grant Agreement No 776758". The present deliverable provides metadata and abstracts of the second series of scientific publications produced by CLIC Consortium during the second year of project activities from M12 (November 2018) to M24 (November 2019). It includes scientific products that have been published in journals, monographs or conference proceedings, uploaded on the project website at https://www.clicproject.eu/scientific-publications/. A list of forthcoming publications has been provided.

// Etay Ziv 1 , Michael Bergen 2 , Hooman Yarmohammadi 1 , F. Ed Boas 1 , E. Nadia Petre 1 , Constantinos T. Sofocleous 1 , Rona Yaeger 3 , David B. Solit 4, 5, 6 , Stephen B. Solomon 1 , Joseph P. Erinjeri 1 1 Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA 2 Department of Radiology, Mount Sinai Hospital, New York, USA 3 Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA 4 Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, USA 5 Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA 6 Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA Correspondence to: Etay Ziv, email: zive@mskcc.org Keywords: biomarkers, colorectal, PI3K, radioembolization, MAPK Received: August 25, 2016 Accepted: January 16, 2017 Published: February 11, 2017 ABSTRACT Purpose : To establish the relationship between common mutations in the MAPK and PI3K signaling pathways and local progression after radioembolization. Materials and Methods : Retrospective review of a HIPAA-compliant institutional review-board approved database identified 40 patients with chemo-refractory colorectal liver metastases treated with radioembolization who underwent tumor genotyping for hotspot mutations in 6 key genes in the MAPK/PI3K pathways (KRAS, NRAS, BRAF, MEK1, PIK3CA, and AKT1). Mutation status as well as clinical, tumor, and treatment variables were recorded. These factors were evaluated in relation to time to local progression (TTLP), which was calculated from time of radioembolization to first radiographic evidence of local progression. Predictors of outcome were identified using a proportional hazards model for both univariate and multivariate analysis with death as a competing risk. Results : Sixteen patients (40%) had no mutations in either pathway, eighteen patients (45%) had mutations in the MAPK pathway, ten patients (25%) had mutations in the PI3K pathway and four patients (10%) had mutations in both pathways. The cumulative incidence of progression at 6 and 12 months was 33% and 55% for the PI3K mutated group compared with 76% and 92% in the PI3K wild type group. Mutation in the PI3K pathway was a significant predictor of longer TTLP in both univariate (p=0.031, sHR 0.31, 95% CI: 0.11-0.90) and multivariate (p=0.015, sHR=0.27, 95% CI: 0.096-0.77) analysis. MAPK pathway alterations were not associated with TTLP. Conclusions : PI3K pathway mutation predicts longer time to local progression after radioembolization of colorectal liver metastases.

The Italian case study in the final deliverable of the Project "HWC - Handle With Care: Assessing and designing methods for evaluation and development of the quality of justice", a project co-financed by European Commission DG Justice (JUST/2015/JACC/AG/QUAL/8547), and coordinated by IRSIG-CNR.

Le necessità di una revisione delle circoscrizioni giudiziarie è da tempo un'esigenza concreta . I cambiamenti radicali intervenuti nel contesto socio-economico in Italia negli ultimi centocinquant'anni, da quando cioè è stata impostata la geografia giudiziaria tuttora vigente1, hanno reso questo impianto anacronistico, inadeguato e certamente troppo costoso (Carnevali 2014a). Il quadro si è poi aggravato a seguito della crisi economico-finanziaria, che ha influenzato le politiche di riforma dei principali settori di policy, compresa la giustizia, nella direzione della razionalizzazione organizzativa e territoriale, ai fini del contenimento della spesa. In questo capitolo, si presenterà l'intero percorso a partire dalla fase di formulazione della policy, con particolare attenzione a come la issue è stata tematizzata e alle caratteristiche del processo di policy design. Successivamente, sarà illustrata l'implementazione della politica e i suoi effetti. In particolare, saranno messi in evidenza gli obiettivi dichiarati e quanto realmente raggiunto, evidenziando i criteri utilizzati nel processo di riforma. Inoltre, saranno indicati i risultati e le prospettive di sviluppo. Nelle considerazioni conclusive verranno precisate le criticità e le opportunità che questa policy ha messo in evidenza nell'ambito delle politiche del servizio giustizia.

Introduction La sarcoidose est une granulomatose systemique chronique benigne d’etiologie indeterminee dont les manifestations cutanees peuvent apparaitre a tous les stades de la maladie. L’objectif de ce travail etait d’etudier les manifestations cutanees de cette maladie en Tunisie. Patients et methodes Il s’agissait d’une etude descriptive, retrospective, colligeant 75 cas de sarcoidose cutanee diagnostiques entre 2001 et 2014 a l’hopital Charles Nicolle de Tunis. Nous avons inclus les patients dont le diagnostic de sarcoidose a ete confirme sur l’histologie associee a une confrontation anatomo-clinique. Resultats L’âge moyen au moment du diagnostic etait 48,7 ans [4–96 ans]. Le delai moyen de consultation etait de 18 mois [1 mois–10 ans]. Le sex-ratio (F/H) etait de 4,5. Les manifestations cutanees etaient a type de petits sarcoides dans 21 cas (28 %), gros sarcoides dans 6 cas (8 %), modification de cicatrices anciennes dans 4 cas (5 %), nodules dermohypodermiques dans 4 cas (5 %), angiolupoides dans 4 cas (5 %), lupus pernio dans 13 cas (17 %), macrocheilite dans 5 cas (6,5 %), plaques annulaires dans 5 cas (6,5 %), plaques psoriasiformes dans 4 cas (5 %). Une atteinte du cuir chevelu etait notee dans 6 cas (8 %) dont 4 a type d’alopecie cicatricielle. L’erytheme noueux a ete revelateur dans uniquement 5 cas (6,5 %). Les manifestations cutanees etaient inaugurales dans 63 cas (85 %). L’intradermoreaction a la tuberculine etait negative dans 48 cas sur 50 (96 %), le dosage de l’enzyme de conversion de l’angiotensine etait augmente dans 11 cas sur 19 (57 %). Le bilan de systematisation montrait une atteinte pulmonaire dans 23 cas (32,8 %), une atteinte ORL dans 6 cas (4 cas d’atteinte nasale et un cas d’atteinte jugale), une atteinte ophtalmologique (sequelle d’uveite anterieure) dans 4 cas, une atteinte hepatique dans 6 cas : cytolyse (3 cas) et cholestase anicterique (3 cas), renale (nephropathie interstitielle) dans 3 cas. Les modalites therapeutiques ont inclus les dermocorticoides, l’allopurinol, les antipaludeens de synthese et la corticotherapie generale en cas d’atteinte systemique severe. L’evolution a ete marquee par une amelioration partielle et la recidive etait la regle. Discussion La sarcoidose est une granulomatose cutaneo-systemique. Elle survient habituellement chez les sujets entre 20 et 40 ans avec une predominance feminine (84 % des cas dans notre serie). Les manifestations cutanees les plus rapportees dans la litterature sont les sarcoides a petits et a gros nodules le lupus pernio et l’erytheme noueux qui ont ete note aussi dans notre serie. Par ailleurs, l’atteinte de cuir chevelu a ete rarement rapportee dans la litterature. Dans notre serie nous avons retrouve 6 cas d’atteinte de cuir chevelu confirmes par l’histologie. Conclusion Les manifestations cutanees de la sarcoidose sont polymorphes peuvent etre revelatrices. Il est donc important de les connaitre et de les biopsier au moindre doute.

EnglishDrawing I sprout from the Recent interventions of Reform on the regime of admissibility of the penal appeals, The writing underlines the actual problem list and the future risks, through the call to some concrete cases that denote the brittleness of the category of the inadmissibility, heralding to behave unreasonable solutions and detriments of the trial guarantees. italianoLo scritto, traendo spunto dai recenti interventi novellistici sul regime di ammissibilita delle impu-gnazioni penali, ne evidenzia le problematiche attuali ed i rischi futuri, attraverso il richiamo ad al-cuni casi concreti che denotano la fragilita della categoria dell’inammissibilita, foriera di comportare soluzioni irragionevoli e detrimenti delle garanzie processuali.

The selective cracking of long-chain normal paraffin's of medium neutral raffinate, derived from a lube oil-phenol extraction unit, by the catalytic dewaxing technique over H-ZSM-5 and NiMo-H-mordenite catalysts was studied. The runs were conducted to produce lube oils with acceptable cold flow properties. The influences of zeolite types, metals loading, and operating reactor temperatures (290°C–475°C) can have a great effect on cracking high pour point n-paraffins into lower ones, and hence a reduction in pour points. An increase in temperature (between 290°C and 375°C) increased wax conversion (percent dewaxing) on H-ZSM-5 compared with NiMo-H-mordenite catalysts due to its higher cracking activity. As a result, large amounts of C1-C4 gases and C5-170°C naphtha were produced. The low pour point lube oils produced from catalytic dewaxing over H-ZSM-5 compared with NiMo-H-mordenite catalyst indicates that the former was more selective for removing wax components than the later. On the other hand,...

Introduction La maladie dermatophytique (MD) est une forme rare d’infection fongique generalisee et chronique. Elle affecte la peau et les phaneres associant parfois des localisations secondaires dermohypodermiques, ganglionnaires voire viscerales. Elle est essentiellement decrite aux pays du Maghreb ou elle est liee a une forte consanguinite. Observation Il s’agit de deux sœurs ZA et ZM âgees respectivement de 18 ans et 7 ans, issues d’un mariage consanguin de 1 er degre. L’ainee ZA est suivie depuis l’âge de 8 ans pour une dermatophytose generalisee. Le debut de la symptomatologie etait marque par l’apparition d’une dermatophytie circinee du visage rapidement etendue au reste du corps. L’examen physique montrait des plaques erythemato-squameuses au niveau du tronc, du dos, du visage, du cou et des membres et s’etendant a tout le cuir chevelu avec rarefaction des cheveux. Un onyxis des doigts et des orteils est associe a une keratodermie plantaire. Des adenopathies cervicales bilaterales ont ete retrouvees. L’examen mycologique isolait Trichophyton Rubrum au niveau de tous les sites preleves. La biopsie ganglionnaire montrait une adenite chronique reactionnelle. L’exploration de l’immunite aussi bien humorale que cellulaire etait normale. Un traitement sequentiel alternant griseofulvine et terbinafine etait instaure. Une recidive etait notee a chaque tentative d’arret du traitement. Pour ZM, le debut de la symptomatologie remontait a l’âge de 2 ans marque par l’installation de dermatophytie etendue du visage, du tronc, et des membres, associee a une teigne du cuir chevelu et un onyxis des doigts et des orteils. Des adenopathies cervicales bilaterales etaient retrouvees. Les prelevements mycologiques permettaient d’isoler un T. Rubrum au niveau de la peau, du cuir chevelu et des ongles. L’exploration de l’immunite humorale et cellulaire etait egalement sans anomalie. La patiente a ete mise sous griseofulvine au long cours permettant de controler la maladie. Discussion Nos observations resument les principales caracteristiques de la MD : l’importance des formes familiales, un debut pediatrique, avec frequence des teignes et l’importance de l’atteinte profonde essentiellement ganglionnaire. Le diagnostic peut etre precocement evoque devant la decouverte d’une teigne a T. Rubrum ou d’un onyxis dermatophytique pediatrique, et devant la recidive frequente a l’arret du traitement. En l’absence d’une prise en charge precoce les lesions peuvent gagner les organes profonds, avec notamment une atteinte osseuse ou cerebrale. Dans ces cas, la survie est serieusement compromise. En Tunisie, la MD atteint plus de filles que de garcons. Une mutation homozygote du gene CARD9 a ete identifiee pouvant expliquer une reponse immunitaire defectueuse contre les dermatophytes. Les differents traitements antifongiques utilise n’ont permis qu’un controle partiel de la maladie. Conclusion La MD est une maladie grave pouvant engager le pronostic vital. L’etude genetique de cette affection ouvre de nouvelles possibilites diagnostiques et probablement therapeutiques ainsi qu’un conseil genetique.

Hunter (2006) states that the image of a shopping centre is one of the factors that may increase the frequency of visits. In addition, the anticipated emotion that the customers experience during shopping is also a variable that influences the frequency of visits. The customers that have emotional relationship with a shopping centre have a higher desire to visit the related shopping centre. The customers’ higher desire to visit the shopping centre will influence the increasing intention to visit a shopping centre and will positively contribute to the frequency (the number) of customers’ visits to a shopping centre. The research was conducted in Yogyakarta, namely to the customers who visited Plaza Ambarrukmo Yogyakarta. The objectives that the researcher would like to investigate were the role of anticipated emotion in mediating the influence of shopping centre image to the desire of visiting the shopping centre, the influence of a desire to visit a shopping centre to the intention of visiting a shopping centre, the influence of an intention to visit a shopping centre to the frequency of visiting a shopping centre, and the difference of customers’ evaluation toward the shopping centre’s image, the anticipated emotion, the intention to visit a shopping centre and the frequency of visiting a shopping centre between men and women. The results of the research conducted to the customers of Plaza Ambarrukmo Yogyakarta Shopping Centre provides a hard evidence that the shopping centre’s image, the anticipated emotion, the desire of visiting a shopping centre and the intention of visiting a shopping centre influence positively and significantly the increase of customers’ visits to Plaza Ambarrukmo Yogyakarta. Anticipated emotion is a mediation variable from the relationship between the shopping centre image and the intention of visiting a shopping centre.

Osteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone-formation and increase in bone-resorption activity. Estrogen is able to suppress production of proinflammatory cytokines such as IL-1, IL-6, IL-7, and TNF-α. This is why these cytokines are elevated in postmenopausal women. Studies have shown that estrogen reduction is able to stimulate focal inflammation in bone.Labisia pumila(LP) which is known to exert phytoestrogenic effect can be used as an alternative to ERT which can produce positive effects on bone without causing side effects. LP contains antioxidant as well as exerting anti-inflammatory effect which can act as free radical scavenger, thus inhibiting TNF-α production and COX-2 expression which leads to decline in RANKL expression, resulting in reduction in osteoclast activity which consequently reduces bone loss. Hence, it is the phytoestrogenic, anti-inflammatory, and antioxidative properties that make LP an effective agent against osteoporosis.

Il saggio affronta il modo in cui l'utilizzo della categoria di genere possa essere un utile strumento di decodifica del linguaggio populista, delle costruzioni narrative e delle proposte politiche che hanno a che vedere con le politiche sulla famiglia, i diritti riproduttivi e la cittadinanza femminile. Il saggio poi affronta il tema della leadership femminile e della presenza politica delle donne all'interno dei movimenti populisti in Europa e nelle Americhe in modo particolare, con un'attenzione particolare ai movimenti populisti di destra.