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1. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Author: G. Hindricks, T. Potpara, N. Dagres, E. Arbelo, J. J. Bax, C. Blomstrӧm-Lundqvist, G. Boriani, M. Castella, G.-A. Dan, P. E. Dilaveris, L. Fauchier, G. Filippatos, J. M. Kalman, M. La Meir, D. A. Lane, J.-P. Lebeau, M. Lettino, G. Y.H. Lip, F. J. Pinto, G. Neil Thomas, M. Valgimigli, I. C. Van Gelder, B. P. Van Putte,, and C. L. Watkins
Subjects: guidelines, atrial fibrillation, anticoagulation, vitamin k antagonists, non-vitamin k antagonist oral anticoagulants, left atrial appendage occlusion, rate control, rhythm control, cardioversion, antiarrhythmic drugs, catheter ablation, pulmonary vein isolation, left atrial ablation, af surgery, upstream therapy, abc pathway, screening, stroke, recommendations., Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
Published: 2021
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2. Visualizing Lucas's Hamiltonian Paths Through the Associahedron 1-Skeleton (Media Exposition).

Author: Kacey Thien-Huu La, Jose E. Arbelo, and Christopher J. Tralie
Published: 2024
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3. The DOPE Distance is SIC: A Stable, Informative, and Computable Metric on Time Series And Ordered Merge Trees.

Author: Christopher J. Tralie, Zachary Schlamowitz, Jose E. Arbelo, Antonio I. Delgado, Charley Kirk, and Nicholas A. Scoville
Published: 2022
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4. Stepwise application of ECG and electrogram based criteria to ensure left bundle branch pacing

Author: M Pujol-Lopez, E Ferro, R Borras, P Garre, E Guasch, M Niebla, E Carro, I Roca-Luque, J B Guichard, L Uribe, E Arbelo, A Porta-Sanchez, M Sitges, J M Tolosana, and L Mont
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): MPL received the Catalan Society of Cardiology Research Grant in 2019 and 2020 (Catalonia, Spain); the Josep Font Grant (2019-2022) from Hospital Clínic Barcelona (Catalonia, Spain). Background Left bundle branch pacing (LBBP) has emerged as an alternative to biventricular pacing. However, lack of a systematic stepwise application of the left bundle branch (LBB) capture criteria complicates implantation. Objective To define a stepwise application of LBBP capture criteria that will simplify implantation and ensure LBB capture. Methods A cohort of 24 patients from the LEVEL-AT trial who received LBBP and had electrocardiographic imaging (ECGI) at 45 days post-implant were included. The usefulness of ECG and electrogram based criteria to predict accurate LBB capture were analyzed. A two-step approach was developed to ensure LBB capture. The gold standard used to confirm LBB capture was the change in ventricular activation pattern and shortening in left ventricular activation time, assessed by ECGI. Results Twenty-two (91.6%) patients showed LBBP capture on ECGI. All patients fulfilled pre-screwing requisites: lead in septal position in left-oblique projection and W paced morphology in V1. In the first step, presence of either right bundle branch conduction delay pattern (qR or rSR in V1) or left bundle branch capture Plus (QRS ≤120ms) resulted in 95% sensitivity and 100% specificity to predict LBB capture, with an accuracy of 95.8%. In the second step, the presence of selective capture (100% specificity, only 41% sensitivity) or a spike-R Conclusions Stepwise application of ECG and electrogram criteria ensured an accurate assessment of left conduction system capture.
Published: 2023

5. Local conduction velocities determined by non-invasive electrocardiographic imaging predict arrhythmia-free survival after pulmonary vein isolation

Author: E Invers-Rubio, I Hernandez-Romero, J Reventos-Presmanes, E Ferro, R Borras, J B Guichard, M S Guillem, A M Climent, J M Tolosana, I Roca-Luque, E Arbelo, A Porta-Sanchez, E Guasch, L Mont, and T F Althoff
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): This project has received funding from the European Union's Horizon Research and Innovation Programme under the Marie-Sklodowska Curie Grant Agreement No. 860974 Background Recurrence rates after atrial fibrillation (AF) ablation are still unsatisfactory. As catheter ablation is primarily targeting pulmonary vein (PV) ectopic activity, it is not surprising that extra-PV arrythmogenic substrate is a key determinant of arrhythmia recurrence. Against this background, several studies have proposed assessment of extra-PV substrate in terms of atrial fibrosis or locally reduced conduction velocities (CV) to guide treatment. However, to date no non-invasive method directly assessing electrical arrhythmogenic substrate has been established in clinical practice, and treatment decisions are commonly based on crude surrogates like AF type or left atrial size. Here we establish and validate a novel non-invasive method based on electrocardiographic imaging (ECGi) to determine atrial arrhythmogenic substrate in terms of reduced local CVs and its predictive value regarding arrhythmia recurrence after PVI. Methods and results 52 consecutive patients scheduled for AF ablation (PVI-only) and 19 healthy controls were prospectively included and received ECGi to assess left and right atrial arrhythmogenic substrate. This ECGi-based method uses 64 electrodes placed on the torso. Subsequently, a 3D model of the torso is acquired as an anatomical reference using a 3D reconstruction camera. A personalised 3D atrial geometry is then derived from a database of human atria using an artificial intelligence-based algorithm. Finally, unipolar surface electrograms are projected onto the cardiac geometry and local CVs are estimated. Mean ECGi-determined atrial CVs were significantly lower in AF patients than in healthy controls, both in a global analysis (1.45±0.15 m/s vs. 1.64±0.15 m/s; p A ROC analysis revealed that a cut-off for this variable of 0.72 m/s best discriminates PVI responders from non-responders: patients with a mean CV >0.72 m/s in all atrial regions showed a 6-months arrhythmia-free survival of 90.9%, whereas patients with one or more atrial regions with a mean CV Conclusion This was the first study to investigate local atrial CV non-invasively and to validate their predictive value regarding outcome after PVI. The absence of ECGi-determined areas of slow conduction well discriminated PVI responders from non-responders. Such non-invasive assessment of electrical arrhythmogenic substrate may guide treatment strategies and be an important step towards personalised AF therapy.
Published: 2023

6. Non-invasive electrocardiographic imaging for the characterization of complex atrial tachyarrhythmias

Author: J Reventos-Presmanes, E Invers-Rubio, E Ferro, R Borras, M Regany, M S Guillem, E Guasch, J M Tolosana, I Roca-Luque, A Porta-Sanchez, E Arbelo, T Althoff, A M Climent, L Mont, and J B Guichard
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): This work was supported by the European Union NextGenerationEU/PRTR. Background – The non-invasive characterization of complex atrial tachyarrhythmias, including atrial flutter (AFL) and focal atrial tachycardia (AT) is challenging. Conventional 12-lead electrocardiogram (ECG) faces several limitations. Planning a precise and preprocedural strategy for complex tachyarrhythmias catheter ablation (CA) is not easy. Purpose To evaluate the diagnostic capacity of a novel electrocardiographic imaging (ECGI) system that does not require previous CT/MRI thoracic imaging. Methods – 42 patients (27 males, CHA2DS2-VASc score 2±1, LVEF 54.5 ± 11.0 % and LA area 31.3 ± 7.0 cm2) undergoing CA for focal AT or AFL were prospectively included in the study. A preprocedural ECGI was managed based on a 64-electrode vest, a torso reconstruction using a 3D real-time acquisition camera, and an artificial intelligence-based method to estimate the patient atrial geometry. The differential diagnostic capacities of non-invasive 12-lead ECG and ECGI were assessed compared with endocavity electroanatomical mapping (EAM) regarding three endpoints: 1) the identification of the involved atrial cavity, 2) the mechanism (focal/micro-reentry or macro-reentry), and (3) the ablation target site defined as the area where the earliest activation was located for focal/micro re-entrant arrhythmias, and the precise anatomical pathway for macro re-entrant tachyarrhythmias. Regarding the ECG, the three endpoints were assessed based on validated algorithms by 2 different observers blinded from the diagnosis. Results – 48 atrial tachyarrhythmias of which 59.5% occurred in the context of a history of CA were evaluated. The non-invasive characterization of complex atrial arrhythmias using this novel ECGI system was possible in 94% of the cases (Figure A): directly for 36 arrhythmias and after decreasing ventricular response using vagal maneuvers for 9. ECGI obtained global accuracy to identify the involved atrial cavity of 91.7%, the mechanism of 89.6%, and the ablation target of 83.3%. In challenging cases, such as in patients with history of CA for AF (n = 27) and in patients without a final diagnosis of counterclockwise typical AFL (n=38) the diagnosis capacity of ECGI is consistent compared to the whole study population. The ECGI diagnostic capacity significantly outclassed the ECG one regarding the identification of the involved cavity (p Conclusions (Figure B) – This novel non-invasive ECGI system that does not require CT/MRI thoracic imaging accurately characterizes complex atrial tachyarrhythmia and outclasses ECG, the current noninvasive diagnostic tool of reference.
Published: 2023

7. Evolution of deceleration zones during VT ablation and relation with cardiac magnetic resonance

Author: S Vazquez-Calvo, P Garre, E Ferro, P Falzone, L Uribe, J B Guichard, J T Ortiz-Perez, E Guasch, E Arbelo, J M Tolosana, L Mont, A Porta-Sanchez, J Brugada, and I Roca-Luque
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background A new functional mapping strategy based on targeting deceleration zones (DZs) has become one of the most commonly used strategies within the armamentarium of substrate-based ablation methods for ventricular tachycardia (VT) in patients with structural heart disease. The classic conduction channels detected by voltage mapping can be accurately determined by cardiac magnetic resonance (CMR). Objectives To analyze the evolution of DZs during ablation and their correlation with CMR. Methods Forty-two consecutive patients with scar-related VT undergoing ablation after CMR (October 2018-December 2020) were included (medium age 65.3±11.8 years; 94.7% male; 73.7% ischemic heart disease). Baseline DZs and their evolution in isochronal late activation remaps were analyzed. A comparison between DZs and CMR conducting channels (CMR-CCs) was realized. Patients were prospectively followed for VT recurrence for one year. Results Overall, 95 DZs were analyzed, 93.68% of which were correlated with CMR-CCs: 44.8% located in the middle segment and 55.2% located in the entrance/exit of the channel. Remapping was performed in 91.7% of patients (1remap: 33.3%, 2remaps: 55.6% and 3remaps: 2.8%). Regarding the evolution of DZs, 72.2% disappeared after the first ablation set, with 14.13% not ablated at the end of the procedure. A total of 32.5% of DZs in remaps correlated with a CMR-CCs already detected, and 17.5% were associated with an unmasked CMR-CCs. One-year VT recurrence was 22.9%. Conclusions DZs are highly correlated with CMR-CCs. In addition, remapping can lead to the identification of hidden substrate initially not identified by electroanatomic mapping but detected by CMR.
Published: 2023

8. Noninvasive stratification of ventricular substrate by electrocardiographic imaging

Author: J Reventos-Presmanes, I Hernandez-Romero, E Invers-Rubio, E Ferro, P Garre, R Borras, J M Tolosana, E Guasch, E Arbelo, A Porta-Sanchez, S Vazquez, J B Guichard, A M Climent, L Mont, and I Roca-Luque
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Introduction Abnormalities of cardiac activation and conduction velocity (CV) are known pro-arrhythmogenic factors. Electrocardiographic imaging (ECGI) is presented as a non-invasive tool for arrhythmogenic substrate analysis. However, electrocardiographic features such propagation activation patterns, and CV are unknown in healthy subjects. In this study, ECGI technology has been evaluated for ventricular tissue stratification in patients with and without structural heart disease. Methods Nineteen patients were included in the study. The healthy ventricles group (Panel A) included 10 patients (8 males, 57 ± 6 years, NYHA = I and LVEF 61 ± 5 %) with normal baseline QRS and normal values of ventricular morphology, function and perfusion assessed by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). The structural heart disease group (Panel B) included 9 patients (9 males, 66±6 years, NYHA 2±1 and LVEF 26±5%) with ischemic cardiomyopathy (ICM) confirmed by LGE-CMR and indication for ablation due to ventricular tachycardia. For each patient, fibrotic areas were identified by ventricular segmentation of the LGE-CMR and ventricles were regionalized in 16 regions. Epicardial electrograms were noninvasively reconstructed by ECGI, late activation time (LAT) and CV maps were calculated to study electrocardiographic features. Results – Ventricles with fibrosis secondary to ICM revealed heterogenous activation patters and higher activation time distribution compared to healthy ventricles (120 ms vs 80 ms; p Conclusions ECGI can noninvasively identify fibrotic tissue by analysing ventricular activation and CV patterns. ECGI could be a potential early tool to identify patients at risk of sudden cardiac death.
Published: 2023

9. Impact of cardiac magnetic resonance channels to localize deceleration zones during VT ablation

Author: S Vazquez-Calvo, P Garre, E Ferro, J B Guichard, P Falzone, E Arbelo, J M Tolosana, E Guasch, L Mont, A Porta-Sanchez, J Brugada, J T Ortiz-Perez, and I Roca-Luque
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Cardiac magnetic resonance has demonstrated to accurately identify voltage conduction channels and it is nowadays an important tool to analyze the arrhythmic substrate, to predict ventricular tachycardia (VT) events and to aid VT ablation. The characteristics of CMR channels (CMR-CCs) that predicts the presence of deceleration zone (DZ) have not been explored. Methods Forty-four consecutive patients with scar-related VT undergoing ablation after CMR (October 2018-July 2021) were included (medium age 64.8±11.6 years; 95.5% male; 70.5% ischemic heart disease, mean ejection fraction of 32.3±7.8). Characteristics of CMR-CCs were analyzed and correlation with DZs both in baseline maps and remaps were performed. Patients were prospectively followed for VT recurrence for one year. Results Overall, 129 automatically detected CMR-CCs were analyzed (2.89±1.83 per patient; length: 52.72±65.44mm (0.18–376.73), CC mass: 1.76±2.46grams (0.01–14.59); protectedness 19.02±24.51% (0.01–143.51)). Overall, 73.6% of CMR-CCs were associated with a DZ: 58.1% CMR-CCs in baseline map and 15.5% with a DZs not observed initially but in remaps. The univariate analysis showed that channels associated with DZs were longer (61.83±73.43 vs. 29.96±32.55, OR 1.01, p0.004), with higher border zone mass (2.02±2.75 vs. 1.09±1.44, OR 1.28, p0.031) and more protectedness (21.90±27.23 vs. 11.46±14.20, OR1.02, p0.036). VT recurrence after one-year follow up was 21.95%. Conclusions Pre ablation CMR can accurately identify channels that correlates with DZs that could be targets for ablation, especially those CMR-CCs with higher length, border zone mass and protectedness. Additionally, some channels not related with DZ in the first map have a clear DZ after abolishing the first region of slow conduction, suggesting a very useful role of CMR to detect potential DZs.
Published: 2023

10. Cardiac injury before and after COVID-19. A longitudinal MRI study

Author: J E Gonzalez, A Doltra, R J Perea, P Lapena, C Garcia-Ribas, J Reventos, G Caixal, J M Tolosana, E Guasch, I Roca-Luque, E Arbelo, M Sitges, S Prat, L Mont, and T F Althoff
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Recent MRI-based studies have raised great concern about frequent cardiac involvement even in mild or asymptomatic COVID-19. However, while signs of myocardial injury were found in large proportions of patients after COVID-19, all studies published to date lack baseline imaging and are therefore unable to discriminate between pre-existing and COVID-19-induced injury. Purpose In this longitudinal study, we aimed to assess the true cardiac impact of COVID-19 based on pre- and post-COVID-19 late gadolinium enhancement (LGE)-MRI. Methods A prospective registry of patients with serial LGE-MRIs was screened for patients with documented SARS-COV-2 infection after cardiac LGE-MRI. Eligible patients then received a post-COVID-19 LGE-MRI using the same scanner and sequence as in the pre-COVID-19 MRI. Inversion recovery prepared T1-weighted gradient echo sequences were acquired in sinus rhythm using ECG gating and a free-breathing 3D navigator, 15–20 minutes after administering an intravenous bolus of 0.2 mmol/kg of gadobutrol. A TI scout sequence was used in order to determine the optimal TI that nullified the left ventricular myocardial signal. The presence of LGE was independently assessed qualitatively by two experienced investigators blinded to patient information. For quantitative analyses a 3D-reconstruction of the left ventricle was performed using ADAS-3D software. LGE was then automatically quantified based on a prespecified signal intensity threshold of ≥3 SD above the mean of a remote non-enhanced myocardial region. Results Pre- and post-COVID LGE-MRI from 31 patients with cardiovascular risk factors that had recovered from mild to moderate COVID-19 (23% hospitalised) were analysed. At a median of 5 months post-COVID-19, LGE-lesions indicative of myocardial injury were encountered in 15 out of 31 patients (48%), which is in line with previous reports. However, intraindividual comparison with the pre-COVID-19 MRI reveiled all of these lesions as pre-existing and thus not COVID-19-related. Quantitative analysis detected no increase in the size of individual LGE-lesions, nor in the global left ventricular LGE-extent. There was no difference in any functional or structural parameter between pre- and post-COVID-19 MRI. Conclusion This longitudinal study in a cohort of patients considered at high risk of cardiac involvement, did not find any evidence for COVID-19-induced myocardial injury. The complete absence of de novo LGE lesions in this cohort is reassuring and indicates that cardiac sequelae of COVID-19 are rare and certainly not as common as previously suggested. Funding Acknowledgement Type of funding sources: None.
Published: 2022

11. Non-invasive assessment of pulmonary vein isolation durability using late gadolinium enhancement MRI

Author: D Padilla, E Ferro, S Prat, A Doltra, R J Perea, J M Tolosana, E Arbelo, E Guasch, I Roca, M Sitges, J Brugada, L Mont, and T F Althoff
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Electrical reconnection of pulmonary veins (PV) is considered an important determinant of recurrent atrial fibrillation (AF) after PV isolation (PVI). However, it requires an invasive repeat procedure to assess durability of PVI. Against this background, in most centers clinically relevant AF recurrences almost automatically trigger repeat ablation procedures aiming at PV re-isolation. However, technological and procedural advances have substantially improved efficacy of catheter ablation. As a result it is increasingly common that all four PVs are found isolated in those repeat procedures. Thus, as ablation of extra-PV targets has failed to show benefit in large randomized trials, more and more often these highly invasive procedures are being performed only to confirm durable PVI. To date, late gadolinium enhancement (LGE)-MRI is the only non-invasive method to assess ablation lesions. However, its predictive value regarding PVI durability has not been systematically determined. Purpose Here we aim to define the ability of LGE-MRI to rule out PV reconnection and its potential to guide patient selection for repeat ablation procedures. Methods This study was based on our prospective registry where all patients receive an LGE-MRI before and after AF ablation. All patients that had undergone a repeat invasive procedure after an initial PVI-only ablation were included, and the ability of LGE-MRI to determine PVI durability was analysed using invasive mapping as a reference. Gradient echo MR sequences were acquired in sinus rhythm and 3D-reconstruction of left atrium and PVs performed using ADAS-3D software. LGE was quantified based on the signal intensity ratio of each voxel relative to the blood pool, applying a previously validated threshold of >1.2 to define LGE indicative of ablation-induced scarring. LGE discontinuations of >3 mm were considered indicative of PV reconnection. For validation, PVI durability was determined invasively based on local bipolar electrograms. Results A total of 142 patients and 284 PV pairs were analysed. LGE-MRI displayed LGE-discontinuations suggestive of PV reconnection in 210 PV pairs (74%). According to invasive mapping, LGE-MRI predicted PV reconnection with high sensitivity (89%), whereas specificity was somewhat lower (48%). Of note, a complete circumferential LGE-lesion reliably ruled out electrical reconnection of the respective PV pair with a negative predictive value of 94.5%. In the patient-based analyses 11% of the patients displayed complete LGE-lesion sets encircling all 4 PVs. None of these patients showed electrical PV reconnection in the invasive repeat procedure. Conclusion Although not frequently encountered, continuous LGE lesions encircling all 4 PVs reliably rule out PV reconnection. Thus, LGE-MRI has the potential to guide treatment decisions in patients with AF recurrences and may help to avoid unnecessary repeat procedures with all their associated risks and costs. Funding Acknowledgement Type of funding sources: None.
Published: 2022

12. Manejo perioperatorio de la fibrilación auricular

Author: M.J. Arguis, R. Navarro, Carmen Gomar, A. Ruiz, C. Roux, Sergi Sabaté, L. Mont, P. Matute, Irene Rovira, J. Galán, Pilar Sierra, A. Regueiro, Guillermina Fita, and E. Arbelo
Subjects: Anesthesiology and Pain Medicine, business.industry, Medicine, Critical Care and Intensive Care Medicine, business, Humanities
Abstract: Resumen La fibrilacion auricular es una complicacion frecuente en el periodo perioperatorio, y cuando aparece se incrementa el riesgo de morbimortalidad perioperatoria debido a ACV, tromboembolismo, fallo cardiaco, IAM, hemorragia debida a anticoagulacion y reingresos hospitalarios. En el presente articulo se recogen las recomendaciones para el manejo de la fibrilacion auricular perioperatoria basandose en las ultimas Guias de Practica Clinica de la fibrilacion auricular publicadas por la Sociedad Europea de Cardiologia y la Sociedad Espanola de Cardiologia, prestando atencion tanto a su optimizacion preoperatoria, como al manejo del episodio agudo perioperatorio. En este sentido se incluyen las ultimas recomendaciones para control de la frecuencia cardiaca, control del ritmo y anticoagulacion.
Published: 2014

13. Saturday, 25 August 2012

Author: A. Welz, B. V. Antwerp, A Di Cori, A. Hager, P. Hatzigiannis, R. De Lucia, C. Yu, A. Apor, M. Niemann, R. Sampognaro, M. Fiuza, M. G. Charlot, N. Cortez Dias, A. Nagae, A. Maciag, T. Sato, M. Valgimigli, D. Levorato, S. Herrmann, T. Kimura, M. Luedde, V. Tzamou, M. Iwabuchi, C. Rickers, J. Sobierajski, J. Vecera, C. Vlachopoulos, K. Goscinska-Bis, S. Goldsmith, H. Ueno, J. Sosna, G. Malerba, W. Li, H. W. Lee, K. Bogaard, K. Yamada, A. Mateo-Martinez, J. Navarova, M. Zeman, K. Dimopoulos, M. P. Lopez Lereu, E. Pelissero, B. Gersak, J. M. Tolosana, S Manzano Fernandez, P. Mertens, J. J. M. Takkenberg, J. W. Kim, R.T. van Domburg, G. P. Diller, H. M. Yang, F. Gustafsson, P. G. Golzio, G. S. Hwang, J. Brugada, S. Stoerk, J. Hess, Y. Cavusoglu, L. Segreti, M. E. Trucco, C. Jacoby, I. Bafakis, T. Isshiuki, L. Pulpon, S. Pires, L. Paperini, A. Cremonesi, H. Baumgartner, C. Tsioufis, M. Valdes-Chavarri, S. Schaefer, M. Totzeck, A. Bochenek, F. Saia, P. Carrilho-Ferreira, M. Khatib, E. M. W. J. Utens, G. Zucchelli, R. Jenni, E. Gencer, N. Carter, A. Kovacs, C. Linde, V. Monivas, A. Marzocchi, L. Baerfacker, L. Mont, R. Weber, F. J. Enguita, T. L. Bergemann, M. Chudzik, A. Chernyavskiy, D. Dragulescu, S. Orwat, B. J. Choi, P. Opic, C. Torp-Pedersen, F. Gaita, V. A. W. M. Umans, A. Lopez-Cuenca, S. B. Christensen, E. C. Bertolino, D. Tousoulis, F. Weidemann, H. H. Kramer, J. Greenslade, J Cosin Sales, M. Gonzalez Estecha, W. Grosso Marra, T. Katsimichas, J. Hoerer, S. Mingo, M. Hochadel, M. A. Castel, M. S. Lattarulo, E. Y. Yun, K. Fattouch, H. S. Lim, A. Uebing, T. Ulus, J. Radosinska, A. Castro Beiras, J. Peteiro, M. Koren, C. Prados, A. Nunes, C. Rammos, C. Thomopoulos, T. Kameyama, F. Borgia, I. Voges, J. L. Looi, L. Cullen, C. Campo, J. Bis, S. Shiva, H. Kato, N. Frey, E. Andrikou, G. H. Gislason, J. Ruvira, A. Kasiakogias, S. Robalo Martins, A. M. Zimmer, M. H. Yacoub, M. Nobuyoshi, U. Zeymer, K. Hanazawa, F. J. Broullon, B. Petracci, K. Hu, A. Petrescu, A. M. Maceira Gonzalez, K. Harada, L. Swan, C. Felix, H. Inoue, T. Haraguchi, N. Cortez-Dias, S. Bisetti, P. Mitkowski, C. Daubert, H. J. Heuvelman, M. R. Gold, G. P. Kimman, O. Gaemperli, H. C. Lee, Y. Takasawa, V. Monivas Palomero, A. C. Andrade, S. Maddock, W. Budts, M. Penicka, F. J. Ten Cate, M. Czajkowski, C. D. Nguyen, K. Kaitani, K. Kintis, S. Castrovinci, D. Liu, T. Benova, K. W. Seo, B. A. Herzog, A. Ionac, C. Jorge, M. Iacoviello, S. Kuramitsu, Y. Nakagawa, K. U. Mert, A. Manari, S. Brili, R. Alonso-Gonzalez, A. J. Six, J. S. Mcghie, A. Goedecke, M. Kelm, F. C. Tanner, F. Marin, C. I. Santos De Sousa, L. Kober, M. Frigerio, D. Adam, B. E. Backus, U. Hendgen-Cotta, A. Belo, D. Couto Mallon, M. Dewor, M. Madsen, J. H. Shin, M. H. Yoon, L. Maiz, P. Lancellotti, A. Nunes Diogo, G. Ertl, R. Pietura, A. Mornos, M. Than, C. Andersson, C. Izumi, E. Liodakis, N. van Boven, Y. Y. Lam, T. Hansen, W. Roell, T. J. Hong, P. Luedicke, M. Sanchez-Martinez, L. Ruiz Bautista, E. N. Oechslin, T. Klaas, M. T. Martinez, W. A. Helbing, J. L. Januzzi, S. Parra-Pallares, A. Romanov, B. Sax, D. Prokhorova, P. Guastaroba, D. Silva, A. Karaskov, P. Kolkhof, B. Bouzas Zubeldia, T. Rassaf, M. Costa, C. Viczenczova, V. Antoncecchi, A. Kempny, J. Bartunek, I. Kardys, J. H. Ahn, C. Hart, A. Berruezo, C. Vittori, W. Vletter, M. Shigekiyo, S. Knob, V. Marangelli, R. Borras, A E Van Den Bosch, S. Y. Choi, E. Arbelo, G. Lazaros, T. Arita, G. Suchan, T. Nakadate, D. Van Der Linde, E. Pokushalov, K. Ando, J. Neutel, P. Biaggi, C. Mornos, R. Corti, M. Landolina, B. Merkely, B. Malecka, H. J. Hippe, S. J. Tahk, J. Aguilar, G. Piovaccari, M. Lutz, D. Rizopoulos, N. Alvarez Garcia, M. Cipriani, T. Kumamoto, S. Kubota, M. Sitges, B. K. Fleischmann, G. Caccamo, D. Tsiachris, M. A. Russ, F. Mutlu, A. Menozzi, J. C. Choi, J. V. Monmeneu, J. C. Yanez Wonenburger, N. Tribulova, C. Forleo, M. Vinci, J. W. Roos-Hesselink, O. Bodea, T. Domei, P. W. Lee, A. Puzzovivo, M. Heikenwaelder, F. Ferraris, C. Stefanadis, M. Kempa, M. Vanderheyden, A. Birdane, J. A. A. E. Cuypers, I. Andrikou, G. Casella, P. Stock, S. Favale, B. Bijnens, A. Kretschmer, J. Bernhagen, M. A. Cavero Gibanel, S. Datta, M. E. Menting, S. Viani, T. Heuft, M. Cikes, A. J. J. C. Bogers, J. Estornell, M. Pham, A. Nadir, F. J. Pinto, M. Hyodo, D. Flessas, C. Chrysohoou, O. Dewald, B. Ren, K. Wustmann, J. C. Burnett, T. Noto, G. Ruvolo, M. Witsenburg, E. Soldati, G. D. Duerr, L. Alonso Pulpon, J. H. Oh, A. Zabek, B. Albrecht-Kuepper, V. Antonakis, M. B. Nielsen, T. Huttl, B. Bacova, A. Piorkowski, I. Z. Cabrita, A. Fanelli, M. A. Weber, J. Segovia, A. I. Romero-Aniorte, J. H. Choi, V. Dosenko, C. Wackerl, J. H. Ruiter, H. Yokoi, S. Ghio, V. Knezl, F. Monitillo, M. Morello, M. Jerosch-Herold, M. L. Geleijnse, A. Bouzas Mosquera, R. Fabregas Casal, H. Mudra, J. Gruenenfelder, U. Floegel, L. Petrescu, M. A. Gatzoulis, S. Shizuta, J. Brachmann, M. G. Bongiorni, M. Pringsheim, J. Mueller, A. Nagy, R. Giron, W. T. Abraham, Y. Takabatake, F. Toyota, D. Martinez Ruiz, M. Lunati, S. Vargiu, L E De Groot De Laat, V. Shabanov, L. Lioni, R. Kast, D. Bettex, K. S. Cha, J. L. Diago, D. Cozma, H. Lieu, M. Giakoumis, E. Orenes-Pinero, G. Murana, A. Kutarski, A.P.J. van Dijk, G. Speziale, A. Boem, L. M. Belotti, B. Igual, A. M. S. Olsen, and H. Lue
Subjects: business.industry, Medicine, Ancient history, Cardiology and Cardiovascular Medicine, business
Published: 2012

14. Adolescent with Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Author: M. García, K. Kestler, A. Rodríguez, G. García-Donas, N. Dominguez, E. Arbelo, M.A. Portero, and C. Muñiz
Subjects: Cancer Research, Pediatrics, medicine.medical_specialty, Oncology, business.industry, Paroxysmal nocturnal hemoglobinuria, medicine, Hematology, Aplastic anemia, medicine.disease, business
Published: 2017

15. 1011Ablation Strategies for different types of atrial fibrillation in Europe - Results of the EORP Atrial Fibrillation Ablation Long-Term Registry

Author: B Schmidt, J Brugada, E Arbelo, C Laroche, S Bayramova, M Bertini, K Letsas, L Pison, E Pokushalov, D Romanov, D Scherr, R Tilz, A Maggioni, and N Dagres
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Published: 2018

16. 198In Hospital and 12-month Follow-up Outcome from the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry: Gender Differences

Author: M Grecu, N Dagres, J Brugada, C Laroche, I C Van Gelder, R Cihak, L Jordaens, J M Rubio Campal, A P Maggioni, E Pokushalov, J Kautzner, L Tavazzi, C Blomstrom Lundqvist, and E Arbelo
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Published: 2018

17. [Perioperative management of atrial fibrillation]

Author: M J, Arguis, R, Navarro, A, Regueiro, E, Arbelo, P, Sierra, S, Sabaté, J, Galán, A, Ruiz, P, Matute, C, Roux, C, Gomar, I, Rovira, L, Mont, and G, Fita
Subjects: Male, Premedication, Pregnancy Complications, Cardiovascular, Electric Countershock, Anticoagulants, Cardiovascular Agents, Postoperative Hemorrhage, Perioperative Care, Postoperative Complications, Heart Conduction System, Heart Rate, Pregnancy, Risk Factors, Atrial Fibrillation, Practice Guidelines as Topic, Humans, Thrombophilia, Female, Intraoperative Complications
Abstract: Atrial fibrillation is a frequent complication in the perioperative period. When it appears there is an increased risk of perioperative morbidity due to stroke, thromboembolism, cardiac arrest, myocardial infarction, anticoagulation haemorrhage, and hospital readmissions. The current article focuses on the recommendations for the management of perioperative atrial fibrillation based on the latest Clinical Practice Guidelines on atrial fibrillation by the European Society of Cardiology and the Spanish Society of Cardiology. This article pays special attention to the preoperative management, as well as to the acute perioperative episode. For this reason, the latest recommendations for the control of cardiac frequency, antiarrhythmic treatment and anticoagulation are included.
Published: 2012

18. Test of band structure calculations for Heusler compounds by spin-resolved photoemission spectroscopy

Author: E. Arbelo Jorge, Stanislav Chadov, M. Kolbe, Martin Jourdan, Hans-Joachim Elmers, Claudia Felser, Gerd Schönhense, and Mathias Kläui
Subjects: Physics, Spin polarization, Condensed matter physics, Photoemission spectroscopy, Binding energy, Angle-resolved photoemission spectroscopy, engineering.material, Condensed Matter Physics, Heusler compound, Electronic, Optical and Magnetic Materials, Condensed Matter::Materials Science, engineering, Condensed Matter::Strongly Correlated Electrons, Electronic band structure, Spin (physics), Intensity (heat transfer)
Abstract: The electronic density of states of epitaxial thin films of the Heusler compound Co${}_{2}$MnGa is probed in situ by spin-resolved ultraviolet photoemission spectroscopy. The experiments reveal several characteristic features in the intensity spectrum and a clear Fermi edge signature. A high spin polarization of $\ensuremath{\simeq}\phantom{\rule{-0.16em}{0ex}}55%$ at the Fermi edge is followed by a sign change at the binding energy of $\ensuremath{\simeq}$0.8 eV. Corresponding calculations of the band structure and the photoemission spectrum were performed employing a spin-polarized relativistic Korringa-Kohn-Rostoker code. Good agreement between the experimental data and calculations was obtained, including dynamical correlation effects.
Published: 2012

19. Temperature dependence of x-ray absorption spectra in the ferromagnetic Heusler alloysMn2VAlandCo2FeAl

Author: E. Arbelo Jorge, P. Klaer, Wenhong Wang, K. Inomata, H. J. Elmers, Hiroaki Sukegawa, and Martin Jourdan
Subjects: Materials science, Condensed matter physics, Absorption spectroscopy, Magnetic circular dichroism, FEAL, Fermi energy, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, symbols.namesake, Ferromagnetism, Ferrimagnetism, Density of states, symbols, Fermi–Dirac statistics
Abstract: We investigate the temperature dependence of the spin-resolved unoccupied density of states (DOS) in ferromagnetic ${\text{Co}}_{2}\text{FeAl}$ and ferrimagnetic ${\text{Mn}}_{2}\text{VAl}$ epitaxial films on MgO(100) using x-ray magnetic circular dichroism. We observe an unexpected strong temperature dependence of the DOS beyond the change expected from the Fermi distribution function. An increase in spectral weight is observed for majority states below the Fermi energy in the case of ${\text{Mn}}_{2}\text{VAl}$ and for minority states above the Fermi energy in the case of ${\text{Co}}_{2}\text{FeAl}$. Reduced atomic order near the interface suppresses the unexpected temperature dependence of the DOS for ${\text{Mn}}_{2}\text{VAl}$.
Published: 2010

20. Spin-resolved unoccupied density of states in epitaxial Heusler-alloy films

Author: E. Arbelo Jorge, P. Klaer, C. Herbort, M. Kallmayer, Hans-Joachim Elmers, H. Schneider, Gerhard Jakob, and Martin Jourdan
Subjects: Materials science, Absorption spectroscopy, Condensed matter physics, Ferromagnetic material properties, Band gap, Atom, Density of states, Fermi energy, Condensed Matter Physics, Spin (physics), Epitaxy, Electronic, Optical and Magnetic Materials
Abstract: We investigate the electronic properties of epitaxial ${\text{Co}}_{2}({\text{Fe}}_{x}{\text{Mn}}_{1\ensuremath{-}x})\text{Si}$, ${\text{Co}}_{2}\text{Fe}({\text{Al}}_{1\ensuremath{-}x}{\text{Si}}_{x})$, and ${\text{Co}}_{2}({\text{Cr}}_{0.6}{\text{Fe}}_{0.4})\text{Al}$ films on MgO(100) substrates using circular dichroism in x-ray absorption spectroscopy (XMCD). Considering final-state electron correlations, the spin-resolved partial density of states at the Co atom can be extracted from XMCD data. The experimental results corroborate the predicted half-metallic ferromagnetic properties of these alloys and reveal a compositional dependence of the Fermi energy position within the minority band gap.
Published: 2009

21. Brillouin light scattering study of Co$_{2}$Cr$_{0.6}$Fe$_{0.4}$Al and Co$_{2}$FeAl Heusler compounds

Author: Jaroslav Hamrle, Simon Trudel, O. Gaier, Burkard Hillebrands, C. Herbort, A. Conca Parra, Martin Jourdan, and E Arbelo
Subjects: Physics, Condensed Matter - Materials Science, Acoustics and Ultrasonics, Scattering, media_common.quotation_subject, Magnon, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Condensed Matter Physics, Asymmetry, Light scattering, Spectral line, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Brillouin zone, Spin wave, Atomic physics, Spectroscopy, media_common
Abstract: The thermal magnonic spectra of Co$_{2}$Cr$_{0.6}$Fe$_{0.4}$Al (CCFA) and Co$_2$FeAl were investigated using Brillouin light scattering spectroscopy (BLS). For CCFA, the exchange constant A (exchange stiffness D) is found to be 0.48 $\mu$erg/cm (203 meV A$^2$), while for Co$_2$FeAl the corresponding values of 1.55 $\mu$erg/cm (370 meV A$^2$) were found. The observed asymmetry in the BLS spectra between the Stokes and anti-Stokes frequencies was assigned to an interplay between the asymmetrical profiles of hybridized Damon-Esbach and perpendicular standing spin-wave modes, combined with the optical sensitivity of the BLS signal to the upper side of the CCFA or Co$_2$FeAl film.
Published: 2008

22. P111SCN1Bb: a new susceptibly gene underlying LQT syndrome

Author: Pedro Beltran-Alvarez, Ramon Brugada, E Arbelo, Anna Iglesias, Helena Riuró, GJ Perez, Oscar Campuzano, Josep Brugada, and Fabiana S. Scornik
Subjects: Genetics, congenital, hereditary, and neonatal diseases and abnormalities, Mutation, Candidate gene, Physiology, Sodium channel, Long QT syndrome, HEK 293 cells, Mutant, Biology, medicine.disease, medicine.disease_cause, Molecular biology, SCN1B, Physiology (medical), medicine, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Gene
Abstract: Long QT Syndrome (LQTS) is a rare inherited cardiac disorder with a high risk of sudden cardiac death in a structurally normal heart. To date, pathogenic mutations have been described as responsible for approximately 70-75% of LQTS patients, mainly in ion channel genes. Mutations in genes encoding the sodium channel α subunit or other regulatory proteins, affecting cardiac sodium current, have been previously related to LQTS. Five sodium channel β subunits have been identified, which are encoded by four genes (SCN1B-4B). Pathogenic mutations in the SCN4B gene, but not in other β subunits, have been reported in LQTS. We tested whether mutations in SCN1B-4B could be responsible for LQTS in patients without mutations in the common LQTS-related genes. We screened for mutations in SCN1B-4B genes in 30 non-related patients clinically diagnosed with LQTS carrying no mutations in the major LQTS-related genes. The screening revealed a novel mutation in the SCN1B gene in an 8-year-old boy. The base change resulted in an amino acid variation from proline to threonine in the alternative C-terminus of the sodium channel β1 subunit (β1b). Using the patch clamp technique, we measured sodium current density, and Nav1.5 gaiting properties, in HEK cells transiently transfected with Nav1.5 and β1b subunits. Our electrophysiological analysis revealed that the mutant β1b altered Nav1.5 function by shifting the window current to negative potentials, increasing recovery from inactivation, decreasing slow inactivation, and increasing late sodium current. In addition, we recorded action potentials from mouse atrial cardiomyocytes, HL-1 cells, transfected with β1b subunits. These experiments revealed that the action potential duration significantly increased when the mutant β1b was overexpressed compared to β1bWT. These findings suggest that the mutation in β1b could explain the LQTS in our patient, revealing SCN1Bb as a new susceptibility gene for LQTS. Our results confirm the importance of sodium channel β subunits in the modulation of cardiac sodium channel. In addition, they highlight the need for further investigation to detect new candidate genes underlying the LQTS patients that currently remain without genetic diagnosis.
Published: 2014

23. Test of band structure calculations for Heusler compounds by spin-resolved photoemission spectroscopy

Author: Kolbe, M., primary, Chadov, S., additional, Jorge, E. Arbelo, additional, Schönhense, G., additional, Felser, C., additional, Elmers, H.-J., additional, Kläui, M., additional, and Jourdan, M., additional
Published: 2012
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24. Element-specific ferromagnetic resonance in epitaxial Heusler spin valve systems

Author: Klaer, P, primary, Hoffmann, F, additional, Woltersdorf, G, additional, Jorge, E Arbelo, additional, Jourdan, M, additional, Back, C H, additional, and Elmers, H J, additional
Published: 2011
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25. Electric transport through nanometric CoFe2O4thin films investigated by conducting atomic force microscopy

Author: Michael Foerster, F. Peiró, Diego Gutiérrez, Josep Fontcuberta, F. Rigato, Martin Jourdan, E. Arbelo, and J. M. Rebled
Subjects: Nanostructure, Materials science, business.industry, Analytical chemistry, General Physics and Astronomy, Sputter deposition, Epitaxy, Sputtering, Electrical resistivity and conductivity, Electrode, Microscopy, Optoelectronics, Thin film, business
Abstract: A systematic study of electric transport through thin (2–8 nm) CoFe2O4 films deposited on epitaxial SrRuO3 bottom electrodes was performed by conducting atomic force microscopy (CAFM). Experimental procedures to investigate transport through thin insulating films by CAFM are critically revised, and the potential of CoFe2O4 films for the use as spin-filtering barriers is assessed. It is concluded that, at room-temperature, a non-tunnel channel significantly contributes to the electric transport, thus limiting the spin-filtering efficiency.
Published: 2012

26. Magnetic and structural properties of Co2FeAl1−xSixthin films

Author: Jorge, E Arbelo, primary, Jourdan, M, additional, Kallmayer, M, additional, Klaer, P, additional, and Elmers, H-J, additional
Published: 2010
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27. Poster Session 1

Author: A. Deshmukh, S. S. Sharma, F. G. Gobal, S. S. Singla, P. H. Hebbar, H. P. Paydak, M. Igarashi, H. Tada, Y. Sekiguchi, H. Yamasaki, K. Kuroki, T. Machino, K. Yoshida, K. Aonuma, J. Shavadia, H. Otieno, G. Yonga, A. Jinah, J. F. Qvist, P. H. Soerensen, U. Dixen, M. A. Ramirez-Marrero, B. Perez-Villardon, D. Gaitan-Roman, M. Jimenez-Navarro, J. L. Delgado-Prieto, E. De Teresa-Galvan, M. De Mora-Martin, P. B. Hebbar, W. X. Wei, S. Bardari, M. Zecchin, R. Salame', L. Vitali Serdoz, A. Di Lenarda, N. Guerrini, G. Barbati, G. Sinagra, K. Hanazawa, K. Kaitani, Y. Nakagawa, I. Lenaerts, R. Driesen, N. Hermida, H. Heidbuchel, S. Janssens, J. L. Balligand, K. R. Sipido, R. Willems, R. Sehra, D. Krummen, C. Briggs, S. Narayan, Y. Tanaka, K. Hirao, T. Nakamura, O. Inaba, A. Yagishita, K. Higuchi, H. Hachiya, M. Isobe, E. Kallergis, E. M. Kanoupakis, H. E. Mavrakis, C. A. Goudis, N. E. Maliaraki, P. E. Vardas, K. Kiuchi, C. Piorkowski, S. Kircher, T. Gaspar, N. Watanabe, A. Bollmann, G. Hindricks, K. Wauters, A. Grosse, S. Raffa, M. Brunelli, J. C. Geller, A. P. Maggioni, L. Gonzini, G. Gussoni, G. Vescovo, M. Gulizia, S. Pirelli, G. Mathieu, G. Di Pasquale, R. Salame, S. Magnani, T. Sakamoto, K. Kumagai, E. Fuke, S. Nishiuchi, T. Hayashi, Y. Miki, S. Naito, S. Oshima, I. E. Hof, E. Vonken, B. K. Velthuis, M. Meine, R. N. W. Hauer, K. P. Loh, J. O. Na, C. U. Choi, E. J. Kim, S. W. Rha, C. G. Park, H. S. Seo, D. J. Oh, H. E. Lim, D. Wichterle, V. Bulkova, M. Fiala, J. Chovancik, J. Simek, P. Peichl, R. Cihak, J. Kautzner, A. Glick, S. Viskin, B. Belhassen, A. Navarrete, F. Conte, A. Ishti, D. Sai, M. Moran, Z. Chitovova, H. Ahmed, K. Mares, J. Skoda, L. Sediva, J. Petru, V. Y. Reddy, P. Neuzil, M. Schmidt, U. Dorwarth, A. Leber, M. Wankerl, J. Krieg, F. Straube, S. Reif, E. Hoffmann, E. Mikhaylov, V. Tikhonenko, D. Lebedev, S. Y. Shin, H. S. Yong, J. I. Choi, S. H. Kim, S. Matsuo, T. Yamane, M. Hioki, K. Ito, R. Narui, T. Date, K. Sugimoto, M. Yoshimura, S. Rolf, P. Sommer, R. Batalov, S. Popov, I. Antonchenko, T. Suslova, S. Fichtner, U. Czudnochowsky, H. L. Estner, S. Ammar, T. Reents, C. Jilek, G. Hessling, I. Deisenhofer, E. Pokushalov, A. Romanov, G. Corbucci, S. Artemenko, D. Losik, V. Shabanov, A. Turov, D. Elesin, M. Abramov, P. Sanders, P. Jais, K. Roberts-Thomson, K. Fukumoto, S. Takatsuki, T. Kimura, N. Nishiyama, Y. Aizawa, T. Sato, S. Miyoshi, K. Fukuda, Y. Roux, J. Tenkorang, P. Carroz, J. Schlaepfer, P. Pascale, A. Forclaz, M. Fromer, E. Pruvot, L. Sknouril, R. Nevralova, M. Dorda, J. Januska, R. Santi, C. Geller, K. Nakamura, K. Kasseno, K. Taniguchi, A. Wutzler, M. Huemer, A. Parwani, L. H. Boldt, D. Blaschke, R. Dietz, W. Haverkamp, B. Coutu, R. Malanuk, M. Ait Said, A. Vicentini, S. Schade, K. Ando, A. Rousseauplasse, T. Deering, B. C. Picarra, A. R. Santos, P. Dionisio, P. Semedo, R. Matos, M. Leitao, A. Jacinto, M. Trinca, C. Wan, J. Glad, S. Szymkiewicz, M. Habibovic, H. Versteeg, A. J. M. Pelle, D. A. M. J. Theuns, L. Jordaens, S. S. Pedersen, S. Pakarinen, L. Toivonen, J. Taggeselle, A. Frey, A. Birkenhagen, S. Kohler, S. K. G. Maier, N. Lobitz, S. Paule, J. Becher, G. Mustafa, A. Ibrahim, G. King, B. Foley, B. Wilkoff, R. Freedman, D. Hayes, S. Kalbfleisch, S. Kutalek, R. Schaerf, I. A. Fazal, M. Tynan, C. J. Plummer, J. M. Mccomb, A. Oto, K. Aytemir, H. Yorgun, U. Canpolat, E. B. Kaya, L. Tokgozoglu, G. Kabakci, H. Ozkutlu, S. Greenberg, F. Hamati, R. Styperek, J. Alonso, D. Peress, O. Bolanos, R. Augostini, M. Pelini, S. Zhang, S. Stoycos, S. Witsaman, K. Mowrey, J. Bremer, A. Oza, G. Ciconte, P. Mazzone, G. Paglino, A. Marzi, P. Vergara, N. Sora, S. Gulletta, P. Della Bella, M. Nagashima, M. Goya, Y. Soga, K. Hiroshima, K. Andou, K. Hayashi, Y. An, M. Nobuyoshi, A. Kutarski, B. Malecka, R. Pietura, P. Osmancik, D. Herman, P. Stros, V. Kocka, P. Tousek, H. Linkova, M. Bortnik, E. Occhetta, G. Dell'era, A. Degiovanni, L. Plebani, P. N. Marino, M. V. Gorev, D. G. Alimov, P. Raju, S. Kully, S. Ugni, S. Furniss, G. Lloyd, N. R. Patel, M. W. Richards, C. E. Warren, M. H. Anderson, M. Hero, J. L. Rey, S. Ouali, S. Azzez, S. Kacem, S. Hammas, H. Ben Salem, E. Neffeti, F. Remedi, E. Boughzela, M. B. Kronborg, P. T. Mortensen, S. H. Poulsen, J. C. Nielsen, E. N. Simantirakis, J. E. Kontaraki, E. G. Arkolaki, S. I. Chrysostomakis, E. G. Nyktari, A. P. Patrianakos, R. C. Funck, C. Harink, H. H. Mueller, S. Koelsch, B. Maisch, V. Bolzani, P. Costandi, R. E. Shehada, N. Butala, B. Coppola, M. Taborsky, P. Heinc, M. Fedorco, V. Doupal, A. Di Cori, G. Zucchelli, E. Soldati, L. Segreti, R. De Lucia, S. Viani, L. Paperini, M. G. Bongiorni, K. J. Gutleben, W. Kranig, C. Barr, M. M. Morgenstern, M. Simon, Y. H. Dalal, M. Landolina, A. Pierantozzi, T. Agricola, M. Lunati, E. Pisano', G. Lonardi, G. Bardelli, G. Zucchi, B. Thibault, M. Dubuc, E. Karst, K. Ryu, P. Paiement, M. D. Carlson, T. Farazi, H. Alhous, L. Mont, J. M. Porres, J. Alzueta, X. Beiras, I. Fernandez-Lozano, A. Macias, R. Ruiz, J. Brugada, S. M. Viani, M. Seifert, T. Schau, V. Moeller, J. Meyhoefer, C. Butter, V. Ganiere, V. Niculescu, G. Domenichini, C. Stettler, P. Defaye, H. Burri, M. Stockburger, E. De Teresa, G. Lamas, M. Desaga, C. Koenig, E. Cobo, X. Navarro, U. Wiegand, M. Blich, S. Carasso, M. Suleiman, I. Marai, L. Gepstein, M. Boulos, M. Sasov, B. Liska, P. Margitfalvi, T. Malacky, M. Svetlosak, E. Goncalvesova, R. Hatala, Y. Takaya, T. Noda, Y. Yamada, H. Okamura, K. Satomi, W. Shimizu, N. Aihara, S. Kamakura, A. Proclemer, S. Boveda, H. Oswald, P. Scipione, A. Da Costa, W. Brzozowski, A. Tomaszewski, A. Wysokinski, E. Arbelo, D. Tamborero, B. Vidal, J. M. Tolosana, M. Sitges, M. Matas, G. L. Botto, C. D. Dicandia, M. Mantica, C. La Rosa, A. D' Onofrio, G. Molon, G. Raciti, R. Verlato, P. W. X. Foley, S. Chalil, K. Ratib, R. E. A. Smith, F. Printzen, A. Auricchio, F. Leyva, R. Abu Sham'a, J. Buber, D. Luria, R. Kuperstein, M. Feinberg, H. Granit, M. Eldar, M. Glikson, K. Vondrak, E. Nof, I. Lipchenca, R.- G. Vatasescu, C. Iorgulescu, C. Caldararu, A. Vasile, S. Bogdan, D. Constantinescu, M. Dorobantu, H. Sakaguchi, A. Miyazaki, T. Yamamoto, K. Fujimoto, S. Ono, H. Ohuchi, M. Martinelli, S. Martins, R. Molina, S. Siqueira, S. A. D. Nishioka, G. L. Peixoto, R. Alkmim-Teixeira, R. Costa, M. M. Meine, A. E. Tuinenburg, P. A. Doevendans, J. Denollet, K. Goscinska-Bis, I. Zupan, H. Van Der, F. Anselme, H. Hartog, M. Block, A. Borri, L. Padeletti, M. Toniolo, G. Zanotto, A. Rossi, E. Raytcheva, L. Tomasi, C. Vassanelli, I. Fernandez Lozano, C. Mitroi, J. Toquero Ramos, V. Castro Urda, V. Monivas Palomero, A. Corona Figueroa, L. Ruiz Bautista, L. Alonso Pulpon, A. S. Jadidi, F. Sacher, A. S. Shah, D. Scherr, N. Derval, M. Hocini, M. Haissaguerre, S. Castrejon Castrejon, C. Largo-Aramburu, J. Sachar, E. Gang, A. Estrada, D. Doiny, E. De Miguel, J. L. Merino, N. Trevisi, A. Ricco, F. Petracca, F. Baratto, A. Bisceglie, G. Maccabelli, A. El-Damaty, J. Sapp, J. Warren, P. Macinnis, M. Horacek, B. Dinov, R. Schoenbauer, F. Braunschweig, A. Arya, D. Andreu, A. Berruezo, J. T. Ortiz, E. Silva, T. M. De Caralt, J. Fernandez-Armenta, A. Perez-Silva, M. Ortega, J. L. Lopez-Sendon, F. Regoli, F. Faletra, G. Nucifora, E. Pasotti, T. Moccetti, C. Klersy, M. Casella, A. Dello Russo, M. Moltrasio, M. Zucchetti, G. Fassini, L. Di Biase, A. Natale, C. Tondo, N. Matsuhashi, H. J. Weig, G. Kerst, S. Weretk, P. Seizer, M. P. Gawaz, J. Schreieck, G. Sarquella-Brugada, F. Prada, C. M. Salling, C. Kolb, M. Pytkowski, A. Maciag, M. Farkowski, A. Jankowska, I. Kowalik, A. Kraska, H. Szwed, P. Maury, A. Duparc, P. Mondoly, A. Rollin, R. Pap, M. Kohari, G. Bencsik, A. Makai, L. Saghy, T. Forster, E. Ebrille, M. Scaglione, C. Raimondo, D. Caponi, P. Di Donna, A. Blandino, S. D. L. Delcre, F. Gaita, I. Roca Luque, L. D. S. Dos, N. R. G. Rivas, A. P. D. Pijuan, J. Perez, J. Casaldaliga, D. G. D. Garcia-Dorado, A. M. M. Moya, H. Sato, T. Yagi, T. Yambe, F. Streitner, C. Dietrich, E. Mahl, N. Schoene, C. Veltmann, M. Borggrefe, J. Kuschyk, P. P. Sadarmin, K. C. K. Wong, K. Rajappan, Y. Bashir, T. R. Betts, C. Leclercq, R. Martins, J. C. Daubert, P. Mabo, M. Koide, G. Hamano, T. Taniguchi, M. Yamato, N. Sasaki, K. Hirooka, Y. Ikeda, Y. Yasumura, W. Dichtl, T. Wolber, U. Paoli, S. Bruellmann, T. Berger, M. Stuehlinger, F. Duru, F. Hintringer, E. Kanoupakis, H. Mavrakis, E. Koutalas, I. Saloustros, C. Goudis, G. Chlouverakis, P. Vardas, J. M. Herre, M. Saeed, L. Saberi, S. Neuman, K. Yamaji, M. Iwabuchi, A. Baranchuk, F. Femenia, R. Miranda Hermosilla, J. C. Lopez Diez, J. L. Serra, M. Valentino, E. Retyk, N. Galizio, W. Kwasniewski, A. Filipecki, W. Orszulak, D. Urbanczyk-Swic, M. Trusz - Gluza, O. Piot, B. Degand, A. Donofrio, P. Scanu, A. Quesada, A. Kloppe, D. Mijic, H. Bogossian, M. Zarse, B. Lemke, J. Tyler, G. Comfort, T. F. Deering, A. E. Epstein, S. M. G. Greenberg, D. S. Goldman, J. Rhude, J. P. Majewski, J. Lelakowski, I. Tomala, C. M. Santos, R. S. Miranda, P. J. Sousa, D. M. Cavaco, P. P. Adragao, R. E. Knops, A. A. Wilde, M. Belhameche, J. S. Hermida, E. Dovellini, G. Frohlig, P. Siot, G. Z. Duray, C. W. Israel, J. Brachmann, K. H. Seidl, M. Foresti, F. Birkenhauer, S. H. Hohnloser, C. Ferreira, P. Mateus, H. Ribeiro, S. Carvalho, A. Ferreira, J. Moreira, W. Kadro, H. Rahim, M. Turkmani, M. Abu Lebdeh, A. Altabban, N. Cerrato, S. Rivera, F. Scazzuso, G. Albina, A. Klein, R. Laino, V. Sammartino, A. Giniger, T. Kvantaliani, M. Akhvlediani, M. Namdar, J. Steffel, S. Jetzer, F. Bayrak, G. B. Chierchia, R. Jenni, P. Brugada, Z. Bakos, M. M. Medvedev M, J. C. Jonas Carlsson, F. H. Fredrik Holmqvist, P. P. Pyotr Platonov, T. Nurbaev, M. Pirnazarov, A. Nikishin, P. Aagaard, A. Sahlen, L. Bergfeldt, E. Simeonidou, S. Kastellanos, C. Varounis, C. Michalakeas, C. Koniari, A. Nikolopoulou, M. Anastasiou-Nana, Y. Furukawa, T. Yamada, T. Morita, K. Tanaka, Y. Iwasaki, M. Kawasaki, Y. Kuramoto, M. Fukunami, C. Blanche, N. Tran, F. Rigamonti, M. Zimmermann, E. Okisheva, D. Tsaregorodtsev, V. Sulimov, D. Novikova, T. Popkova, E. Udachkina, Y. Korsakova, A. Volkov, A. Novikov, E. Alexandrova, E. Nasonov, P. Arsenos, K. Gatzoulis, G. Manis, P. Dilaveris, T. Gialernios, E. Kartsagoulis, S. Asimakopoulos, C. Stefanadis, M. Marocolo, O. Barbosa Neto, A. C. Carvalho, S. R. Marques Neto, G. R. Mota, P. R. B. Barbosa, A. Fernandez-Fernandez, S. Manzano Fernandez, F. J. Pastor-Perez, O. Barquero-Perez, R. Goya-Esteban, M. Salar, J. L. Rojo-Alvarez, A. Garcia-Alberola, M. Takigawa, M. Kawamura, T. Aiba, T. Sakaguchi, H. Itoh, M. Horie, T. Igarashi, J. Negishi, N. Toyota, O. Yamada, M. Papavasileiou, F. Cabrera Bueno, M. J. Molina Mora, J. Alzueta Rodriguez, A. Barrera Cordero, E. De Teresa Galvan, A. S. Revishvili, T. Dzhordzhikiya, O. Sopov, G. Simonyan, O. Lyadzhina, E. Fetisova, V. Kalinin, J. C. Balt, R. C. Steggerda, L. V. A. Boersma, M. C. E. F. Wijffels, E. F. D. Wever, J. M. Ten Berg, R. P. Ricci, L. Morichelli, A. D'onofrio, D. Vaccari, L. Calo', G. Buja, N. Rovai, A. Gargaro, J. Sperzel, G. Speca, L. Santini, J. Haarbo, K. Dubin, M. Carlson, A. Garcia Quintana, H. Mendoza-Lemes, L. Garcia Perez, S. Led Ramos, E. Caballero Dorta, M. Matinez De Espronceda, V. Piro Mastracchio, L. Serrano Arriezu, L. Sciarra, M. Marziali, E. Marras, M. Rebecchi, G. Allocca, E. Lioy, P. Delise, V. E. Santobuono, M. Iacoviello, F. Nacci, G. Luzzi, A. Puzzovivo, M. Memeo, F. Quadrini, S. Favale, M. E. Trucco, M. Arce, J. Palazzolo, W. Uribe, R. Maggi, T. Furukawa, F. Croci, A. Solano, M. Brignole, A. Lebreiro, A. Sousa, A. S. Correia, P. Lourenco, S. Oliveira, M. Paiva, J. Freitas, M. J. Maciel, N. Linker, G. Rieger, C. Garutti, N. Edvardsson, R. Salguero Bodes, M. De Riva Silva, A. Fontenla Cerezuela, M. Lopez Gil, E. Mejia Martinez, A. Jurado Roman, S. Garcia Alvarez, F. Arribas Ynsaurriaga, N. R. Petix, A. Del Rosso, V. Guarnaccia, A. Zipoli, F. Rabajoli, G. Foglia Manzillo, C. Tolardo, C. Checchinato, S. Chiaravallotti, M. Santarone, M. T. Spinnler, C. Podoleanu, A. Frigy, D. Dobreanu, C. Ginghina, and E. Carasca
Subjects: Lv function, medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, Predictive value, Value (mathematics), Surgery
Abstract: was higher in the NRG (p 0.70 was the more accurate RT-MCE value to predict LV regional recovery with positive predictive value of 70% and negative predictive value of 56% (p
Published: 2011

28. Poster Session 4

Author: H. Tada, H. Yamasaki, Y. Sekiguchi, M. Igarashi, K. Kuroki, T. Machino, K. Yoshida, K. Aonuma, F. R. Heinzel, H. Forstner, P. Lercher, E. Bisping, B. Rotman, F. M. Fruhwald, B. M. Pieske, R. Dabrowski, I. Kowalik, A. Borowiec, E. Smolis-Bak, A. Trybuch, C. Sosnowski, H. Szwed, M. A. Baturova, A. Lindgren, Y. V. Shubik, B. Olsson, P. G. Platonov, K. C. Van Den Broek, J. Denollet, J. Widdershoven, N. Kupper, R. Allam, R. A. G. A. B. Allam, W. A. G. D. Y. Galal, H. A. Y. A. M. El-Damnhoury, A. Y. M. A. N. Mortada, J. Jimenez-Candil, A. Martin, J. Hernandez, F. Martin, M. Gallego, C. Martin-Luengo, J. G. Quintanilla, J. Moreno Planas, R. Molina-Morua, T. Archondo, M. J. Garcia-Torrent, N. Perez-Castellano, C. Macaya, J. Perez-Villacastin, J. Saiz, C. Tobon, J. F. Rodriguez, F. Hornero, J. M. Ferrero, K. Ito, T. Date, M. Kawai, M. Hioki, R. Narui, S. Matsuo, M. Yoshimura, T. Yamane, N. Tabatabaei, G. Lin, B. D. Powell, R. Smairat, J. F. Glockner, P. A. Brady, S. Fichtner, U. Czudnochowsky, H. Estner, T. Reents, C. Jilek, S. Ammar, G. Hessling, I. Deisenhofer, D. C. Shah, J. Kautzner, N. Saoudi, C. Herrera, P. Jais, G. Hindricks, P. Neuzil, K. H. Kuck, K. C. K. Wong, M. Jones, N. Qureshi, A. Muthumala, T. R. Betts, Y. Bashir, K. Rajappan, T. Vogtmann, M. Wagner, J. Schurig, P. Hein, B. Hamm, G. Baumann, A. Lembcke, B. Saad, C. Slater, L. A. Oliveira, R. Elias, A. Camiletti, D. Moura, P. Maldonado, L. E. Camanho, A. Bulava, J. Hanis, D. Sitek, A. Novotny, W. B. Chik, T. W. Lim, H. K. Choon, V. A. See, R. Mccall, L. Thomas, D. L. Ross, S. P. Thomas, J. Chen, A. De Bortoli, O. Rossvoll, P. I. Hoff, E. Solheim, L. Z. Sun, P. Schuster, O. J. Ohm, A. V. Ardashev, E. Zhelyakov, M. S. Rybachenko, A. V. Konev, Y. U. N. Belenkov, M. Gunawardene, K. R. J. Chun, B. Schulte-Hahn, V. Windhorst, M. Kulikoglu, B. Nowak, B. Schmidt, G. A. Albina, R. S. Rivera, F. Scazzuso, R. L. Laino, G. A. Giniger, E. Arbelo, N. Calvo, D. Tamborero, D. Andreu, R. Borras, A. Berruezo, J. Brugada, L. Mont, L. Stefan, M. Eisenberger, E. Celentano, P. Peytchev, O. Bodea, P. Geelen, T. De Potter, M. M. Oliveira, N. Silva, P. S. Cunha, J. Feliciano, A. Lousinha, A. Toste, S. Santos, R. C. Ferreira, H. Matsuda, T. Harada, K. Soejima, Y. Ishikawa, K. Mizukoshi, T. Sasaki, K. Mizuno, F. Miyake, P. P. Adragao, D. Cavaco, R. Miranda, M. Santos, F. Morgado, K. Reis Santos, R. Candeias, S. Marcelino, F. Zoppo, G. Grandolino, F. Zerbo, E. Bertaglia, S. M. Schlueter, O. Grebe, E. G. Vester, A. L. Miracle Blanco, A. Arenal Maiz, F. Atienza Fernandez, T. Datino Romaniega, E. Gonzalez Torrecilla, G. Eidelman, J. Hernandez Hernandez, F. Fernandez Aviles, K. Fukumoto, S. Takatsuki, T. Kimura, N. Nishiyama, Y. Aizawa, T. Sato, S. Miyoshi, K. Fukuda, B. Richter, M. Gwechenberger, A. Socas, G. Zorn, S. Albinni, M. Marx, J. Wojta, H. Goessinger, T. Deneke, O. Balta, M. Paesler, K. Buenz, H. Anders, M. Horlitz, A. Muegge, D.- I. Shin, K. Natsuyama, K. M. Yamaguchi, Y. N. Nishida, J. Kosiuk, K. Bode, A. Arya, C. Piorkowski, T. Gaspar, P. Sommer, A. Bollmann, D. Wichterle, P. Peichl, J. Simek, S. Havranek, V. Bulkova, R. Cihak, A. Jurado Roman, R. Salguero Bodes, M. Lopez Gil, A. Fontenla Cerezuela, M. De Riva Silva, F. Arribas Ynsaurriaga, A. I. Fernandez Herranz, S. De Dios Perez, A. S. Revishvili, M. Dishekov, Z. Tembotova, S. Barsamyan, D. Vaccari, C. Alvarenga, I. Jesus, J. Layher, A. Takahashi, N. Singh, P. Siot, J. P. Elkaim, I. Savelieva, L. Mcclelland, A. Lovegrove, S. Jones, J. Camm, A. F. Folino, R. Breda, P. Calzavara, J. Comisso, F. Borghetti, S. Iliceto, G. Buja, R. Mlynarski, A. Mlynarska, M. Sosnowski, J. Wilczek, P. Mabo, G. Carrault, P. Bordachar, A. Makdissi, L. Duchemin, C. Alonso, G. Neri, G. Masaro, S. Vittadello, A. Gardin, A. Barbetta, F. Di Gregorio, E. Sciaraffia, M. R. Ginks, J. S. Gustafsson, M. C. Hollmark, C. A. Rinaldi, C. Blomstrom Lundqvist, S. Brusich, D. Tomasic, B. Ferek-Petric, Z. Mavric, A. Kutarski, B. Malecka, A. Kolodzinska, M. Grabowski, E. V. Dovellini, L. Giurlani, G. Cerisano, N. Carrabba, R. Valenti, D. Antoniucci, G. Opolski, G. Tomassoni, J. Baker, R. Corbisiero, D. Martin, I. Niazi, R. Sheppard, J. Sperzel, K. Gutleben, J. Petru, L. Sediva, J. Skoda, P. Mazzone, G. Ciconte, P. Vergara, A. Marzi, G. Paglino, N. Sora, S. Gulletta, P. Della Bella, R. Pietura, M. Czajkowski, N. Cabanelas, V. P. Martins, M. Alves, F. X. Valente, L. Marta, A. Francisco, R. Silva, G. Ferreira Da Silva, Y. Huo, F. Holmqvist, J. Carlson, U. Wetzel, P. Platonov, E. Nof, R. Abu Shama, R. Kuperstein, M. S. Feinberg, M. Eldar, M. Glikson, D. Luria, P. Kubus, O. Materna, R. A. Gebauer, T. Matejka, R. Gebauer, T. Tlaskal, J. Janousek, A. Muessigbrodt, S. Richter, M. Stockburger, S. Boveda, P. Defaye, P. Stancak Branislav, G. Kaliska, M. Rolando, J. Moreno, M.- A. G. Ohlow, B. Lauer, B. Buchter, M. Schreiber, J. C. Geller, J. E. Val-Mejias, S. Ouali, S. Azzez, S. Kacem, H. Ben Salem, S. Hammas, E. Neffeti, F. Remedi, E. Boughzela, H. Miyazaki, S. Miyanaga, K. Shibayama, M. Tokuda, T. Kudo, B. Coppola, R. E. N. Shehada, P. Costandi, J. Healey, S. H. Hohnloser, M. R. Gold, A. Capucci, I. C. Van Gelder, M. Carlson, C. P. Lau, S. J. Connolly, M. D. Bogaard, G. E. Leenders, B. Maskara, A. E. Tuinenburg, P. Loh, R. N. Hauer, P. A. Doevendans, M. Meine, B. Thibault, M. Dubuc, E. Karst, K. Ryu, P. Paiement, T. Farazi, V. Puetz, C. Berndt, J. Buchholz, A. Dorszewski, C. Mornos, D. Cozma, A. Ionac, L. Petrescu, A. Mornos, S. Pescariu, M. Benser, G. Roscoe, S. De Jong, G. Roberts, P. Boileau, A. Rec, C. Folman, A. Morttada, M. Abd El Kader, R. Samir, R. Roushdy, S. Khaled, M. Abo El Maaty, B. Van Gelder, P. Houthuizen, F. A. Bracke, J. Osca Asensi, D. Tejada, J. M. Sanchez, B. Munoz, O. Cano, M. Rodriguez, M. J. Sancho-Tello, J. Olague, W. Hou, S. Rosenberg, S. Koh, J. Poore, J. Snell, M. Yang, D. Nirav, G. Bornzin, T. Deering, D. Dan, A. C. Wickliffe, S. Cazeau, K. Karimzadeh, S. Mukerji, C. Loghin, B. Kantharia, M. A. Jones, J. Lamba, C. S. Simpson, D. P. Redfearn, K. A. Michael, M. Fitzpatrick, A. Baranchuk, M. Heinke, B. Ismer, H. Kuehnert, R. Surber, A. M. Haltenberger, D. Prochnau, H. R. Figulla, N. Delarche, O. Bizeau, P. Couderc, A. Chapelet, W. Amara, A. Lazarus, S. Krupickova, C. J. M. Van Deursen, M. Strik, K. Vernooy, A. Van Hunnik, M. Kuiper, H. J. G. M. Crijns, F. W. Prinzen, N. Islam, D. Gras, W. Abraham, L. Calo, U. Birgersdotter-Green, C. Clyne, J. Herre, N. Klein, O. Kowalski, R. Lenarczyk, P. Pruszkowska, A. Sokal, T. Kukulski, T. Zielinska, S. Pluta, Z. Kalarus, J. O. Schwab, M. Gasparini, F. Anselme, J. Clementy, M. Santini, J. Martinez Ferrer, V. Burrone, E. Santi, R. Nevzorov, A. Porter, J. Kusniec, G. Golovchiner, T. Ben-Gal, B. Strasberg, M. Haim, R. Rordorf, S. Savastano, A. Sanzo, A. Vicentini, B. Petracci, M. De Amici, L. Striuli, M. Landolina, J. M. Tolosana, A. M. Martin, A. Hernandez-Madrid, A. Macias, I. Fernandez-Lozano, J. Osca, A. Quesada, Y. Noguchi, S. Shahrzad, N. Karim Soleiman, A. Tavoosi, S. Taban, Z. Emkanjoo, M. Fukunaga, M. Goya, K. Hiroshima, M. Ohe, K. Hayashi, M. Iwabuchi, H. Nosaka, M. Nobuyoshi, D. Doiny, A. Perez-Silva, S. Castrejon Castrejon, A. Estrada, M. Ortega, J. L. Lopez-Sendon, J. L. Merino, F. J. Garcia Fernandez, R. Gallardo, M. Pachon, J. Almendral, J. Martin, D. Yahya, B. Al-Mogheer, S. Gouda, E. Eweis, M. El Ramly, A. Abdelwahab, W. Kassenberg, F. H. M. Wittkampf, I. E. Hof, J. H. Heijden, K. G. E. J. Neven, R. N. W. Hauer, F. Baratto, E. Bignami, F. Pappalardo, G. Maccabelli, D. Nicolotti, A. Zangrillo, M. Nagashima, Y. An, A. Okreglicki, C. Russouw, R. Tilz, Y. Yoshiga, S. Mathew, A. Fuernkranz, A. Rillig, E. Wissner, F. Ouyang, A. De Sisti, J. Tonet, F. Gueffaf, F. Touil, P. Aouate, F. Hidden-Lucet, H. Makimoto, K. Satomi, Y. Yamada, H. Okamura, T. Noda, W. Shimizu, N. Aihara, S. Kamakura, A. Perez Silva, S. Castrejon, M. Gonzalez Vasserot, J. Senges, J. Brachmann, D. Andresen, E. Hoffmann, B. Schumacher, S. Willems, B. Springer, C. Kolb, F. Akca, T. Bauernfeind, N. M. S. De Groot, B. Schwagten, M. Witsenburg, L. Jordaens, T. Szili-Torok, Y. Hata, R. Nakagami, T. Watanabe, A. Sato, H. Watanabe, T. Kabutoya, T. Mituhashi, D. A. M. J. Theuns, T. Smith, S. S. Pedersen, L. Dabiri-Abkenari, M. W. Prull, S. Unverricht, A. Bittlinsky, H. Wirdemann, B. Sasko, S. Wirdeier, H. J. Trappe, E. Zorio Grima, J. Rueda, P. Medina, T. Jaijo, T. Sevilla, M. A. Arnau, A. Salvador, A. H. Starrenburg, K. Kraaier, M. F. Scholten, J. Van Der Palen, S. De Haan, J. Commandeur, K. De Boer, A. M. Beek, A. C. Van Rossum, C. P. Allaart, P. Berne, J. M. Porres, J. A. Arnaiz, R. Brugada, S. Man, A. C. Maan, J. Thijssen, E. E. Van Der Wall, M. J. Schalij, L. Burattini, R. Burattini, C. A. Swenne, A. Bonny, I. Ditah, F. Larrazet, R. Frank, G. Fontaine, P. H. Van Der Voort, M. Alings, A. Shimane, K. Okajima, G. Kanda, K. Yokoi, S. Yamada, Y. Taniguchi, T. Hayashi, T. Kajiya, M. C. Santos, J. Wright, J. Betts, R. Denman, L. Dominguez-Perez, M. A. Arias Palomares, J. Toquero, E. Diaz-Infante, L. Tercedor, I. Valverde, A. Napp, S. Joosten, D. Stunder, M. Zink, N. Marx, P. Schauerte, J. Silny, M. E. Trucco, M. Arce, J. Palazzolo, F. Femenia, J. M. Glad, S. J. Szymkiewicz, J. Fernandez-Armenta, O. Camara, L. L. Mont, E. Diaz, E. Silva, A. Frangi, B. Brembilla-Perrot, F. Laporte, J. Morinigo, C. Ledesma, C. Hadid, M. Ortiz, C. Wolpert, E. Cobo, X. Navarro, F. Arribas, Y. Miki, S. Naitoh, K. Kumagai, K. Goto, K. Kaseno, S. Oshima, K. Taniguchi, S. Rivera, G. Albina, A. Klein, R. Laino, V. Sammartino, A. Giniger, M. Muggenthaler, H. Raju, M. Papadakis, N. Chandra, R. Bastiaenen, E. R. Behr, S. Sharma, N. Samniah, Y. Radezishvsky, H. Omari, U. Rosenschein, A. R. Perez Riera, M. Ferreira, W. M. Hopman, W. F. Mcintyre, A. R. Baranchuk, W. Wongcharoen, K. Keanprasit, A. Phrommintikul, R. Chaiwarith, A. Yagishita, H. Hachiya, T. Nakamura, Y. Tanaka, K. Higuchi, M. Kawabata, K. Hirao, M. Isobe, V. Stoickov, S. Ilic, M. Deljanin Ilic, P. Aagaard, A. Sahlen, L. Bergfeldt, F. Braunschweig, A. Sousa, A. Lebreiro, C. Sousa, S. Oliveira, A. S. Correia, I. Rangel, J. Freitas, M. J. Maciel, E. Asensio Lafuente, A. A. C. Aguilera, M. A. C. C. Corral, K. L. M. C. Mendoza, P. E. N. D. Nava, A. L. R. C. Rendon, L. V. C. Villegas, L. C. M. Castillo, R. Schaerf, R. Develle, C. Oliver, P. Y. Zinzius, R. A. Providencia, A. Botelho, J. Trigo, J. Nascimento, N. Quintal, P. Mota, A. M. Leitao-Marques, J. Borbola, P. Abraham, C. S. Foldesi, A. Kardos, S. Almeida, M. B. Santos, R. Quaresma, F. B. Morgado, P. Adragao, M. Fatemi, R. Didier, G. Le Gal, Y. Etienne, Y. Jobic, M. Gilard, J. Boschat, J. Mansourati, M. Zubaid, W. Rashed, A. Alsheikh-Ali, W. Almahmeed, A. Shehab, K. Sulaiman, N. Asaad, H. Amin, L. V. A. Boersma, M. Swaans, M. Post, B. Rensing, K. Jarverud, M. Broome, K. Noren, T. Svensson, S. Hjelm, M. Hollmark, A. Bjorling, K. Maeda, M. Takagi, K. Suzuki, H. Tatsumi, M. Yoshiyama, E. Simeonidou, C. Michalakeas, S. Kastellanos, C. Varounis, A. Nikolopoulou, C. Koniari, M. Anastasiou-Nana, T. Furukawa, R. Maggi, C. Bertolone, D. Fontana, M. Brignole, A. Z. Pietrucha, M. Wnuk, I. Bzukala, D. Mroczek-Czernecka, E. Konduracka, O. Kruszelnicka, W. Piwowarska, J. Nessler, N. Edvardsson, G. Rieger, C. Garutti, N. Linker, C. Jorge, J. Silva Marques, A. Veiga, J. Cruz, M. J. Correia, J. Sousa, G. Miltenberger-Miltenyi, A. Nunes Diogo, D. Matic, I. Mrdovic, G. Stankovic, M. Asanin, N. Antonijevic, M. Matic, N. Kocev, Z. Vasiljevic, M. A. Ramirez-Marrero, B. Perez-Villardon, J. L. Delgado-Prieto, M. Jimenez-Navarro, E. De Teresa-Galvan, M. De Mora-Martin, K. Sztefko, A. Malek, N. De Groot, T. Shalganov, M. Schalij, N. Rivas, J. Casaldaliga, I. Roca, A. Pijuan, J. Perez-Rodon, L. Dos, D. Garcia-Dorado, A. Moya, A.- E. Baruteau, A. Behaghel, S. Chatel, J. J. Schott, J. C. Daubert, H. Le Marec, V. Probst, J. Navarro-Manchon, P. Molina, B. Igual, M. Bermejo, J. Giner, V. J. A. Bourgonje, M. A. Vos, S. Ozdemir, N. Doisne, M. A. G. Van Der Heyden, A. A. B. Van Veen, K. Sipido, G. Antoons, P. I. Altieri, N. Escobales, M. Crespo, H. L. Banchs, L. Sciarra, R. Bloise, G. Allocca, E. Marras, E. Lioy, P. Delise, S. Priori, and L. Calo'
Subjects: medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Diastole, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: spectively), (p
Published: 2011

29. Poster Session 3

Author: G. M. T. Fabbri, S. Baldasseroni, D. Panuccio, M. Zoni Berisso, M. Scherillo, D. Lucci, G. Di Pasquale, G. Mathieu, I. Burazor, M. Burazor, Z. Perisic, V. Atanaskovic, V. Erakovic, A. Stojkovic, T. Vogtmann, C. Schoebel, S. Sogorski, M. Sebert, J. Schaarschmidt, I. Fietze, G. Baumann, T. Penzel, C. Mornos, A. Ionac, D. Cozma, D. Dragulescu, A. Mornos, L. Petrescu, L. Pescariu, B. Brembilla-Perrot, H. Khachab, F. Lamberti, C. Bellini, R. Remoli, T. Cogliandro, R. Nardo, F. Bellusci, V. Mazzuca, A. Gaspardone, L. E. Aguinaga Arrascue, A. Bravo, P. Garcia Freire, P. Gallardo, E. Hasbani, R. Quintana, J. Dantur, K. Inoue, A. Ueoka, Y. Tsubakimoto, T. Sakatani, A. Matsuo, H. Fujita, M. Kitamura, M. Wegrzynowska, E. Konduracka, A. Z. Pietrucha, D. Mroczek-Czernecka, A. Paradowski, I. Bzukala, J. Nessler, O. Igawa, M. Adachi, H. Atarashi, Y. Kusama, E. Kodani, R. Okazaki, A. Nakagomi, Y. Endoh, J. L. Baez-Escudero, A. S. Dave, C. M. Sasaridis, M. Valderrabano, R. Tilz, R. Bai, L. Di Biase, G. J. Gallinghouse, D. Gibson, A. Pisapia, O. Wazni, A. Natale, A. Arujuna, R. Karim, A. Rinaldi, M. Cooklin, K. Rhode, R. Razavi, M. O'neill, J. Gill, S. Kusa, Y. Komatsu, K. Kakita, K. Takayama, H. Taniguchi, K. Otomo, Y. Iesaka, S. Ammar, T. Reents, S. Fichtner, J. Wu, P. Zhu, C. Kolb, G. Hessling, I. Deisenhofer, G. Gilbert, P. Mohanty, J. Cunningham, T. Metz, R. Horton, S. Tao, Y. Yamauchi, H. Okada, S. Maeda, T. Obayashi, M. Isobe, J. Chan, S. Johar, T. Wong, V. Markides, W. Hussain, M. Konstantinidou, E. Wissner, A. Fuernkranz, Y. Yoshiga, A. Metzner, K.- H. Kuck, F. Ouyang, K. Kettering, F. Gramley, H. Mollnau, C. Weiss, S. Bardeleben, L. Biasco, M. Scaglione, D. Caponi, P. Di Donna, D. Sergi, N. Cerrato, A. Blandino, F. Gaita, M. Fiala, D. Wichterle, L. Sknouril, V. Bulkova, J. Chovancik, R. Nevralova, J. Pindor, J. Januska, J. I. Choi, J. E. Ban, N. Yasutsugu, J. S. Park, J. S. Jung, H. E. Lim, S. W. Park, Y. H. Kim, M. Kuhne, T. Reichlin, P. Ammann, B. Schaer, S. Osswald, C. Sticherling, M. Ohe, M. Goya, K. Hiroshima, K. Hayashi, Y. Makihara, M. Nagashima, M. Fukunaga, Y. An, U. Dorwarth, M. Schmidt, M. Wankerl, J. Krieg, F. Straube, E. Hoffmann, S. Kathan, P. Defaye, A. Mbaye, R. Cassagneau, V. Gagniere, P. Jacon, E. Pokushalov, A. Romanov, S. Artemenko, V. Shabanov, D. Elesin, I. Stenin, A. Turov, D. Losik, K. Kondo, J. Miake, A. Yano, K. Ogura, M. Kato, C. Shigemasa, Y. Sekiguchi, H. Tada, K. Yoshida, Y. Naruse, H. Yamasaki, M. Igarashi, T. Machino, K. Aonuma, S. Chen, S. Liu, G. Chen, W. Meng, F. Zhang, Y. Yan, L. Sciarra, S. Dottori, C. Lanzillo, E. De Ruvo, L. De Luca, M. Minati, E. Lioy, L. Calo', J. Lin, Z. Nie, M. Zhu, X. Wang, J. Zhao, W. Hu, H. Tao, J. Ge, B. Johansson, B. Houltz, N. Edvardsson, H. Schersten, T. Karlsson, B. Wandt, E. Berglin, R. H. Hoyt, B. P. Jenson, S. A. I. P. Trines, J. Braun, A. Tjon Joek Tjien, K. Zeppenfeld, G. Tavilla, R. J. M. Klautz, M. J. Schalij, R. Krausova, R. Cihak, P. Peichl, J. Kautzner, J. Pirk, I. Skalsky, J. Maly, K. Imai, T. Sueda, K. Orihashi, B. C. Picarra, A. R. Santos, P. Dionisio, P. Semedo, R. Matos, M. Leitao, M. Banha, M. Trinca, D. H. J. Elder, J. George, R. Jain, C. C. Lang, A. M. Choy, M. Konert, S. Loescher, A. Hartmann, E. Aversa, R. Chirife, E. Sztyglic, H. Mazzetti, O. Mascheroni, M. C. Tentori, R. M. Pop, A. D. Margulescu, R. Dulgheru, O. Enescu, C. Siliste, D. Vinereanu, A. Menezes Junior, A. R. Castro Carneiro, B. L. De Oliveira, A. N. Shah, B. Kantharia, R. De Lucia, E. Soldati, L. Segreti, A. Di Cori, G. Zucchelli, S. Viani, L. Paperini, M. G. Bongiorni, A. Kutarski, M. Czajkowski, R. Pietura, B. Malecka, J. Heintze, L. Eckardt, A. Bauer, M. Meine, L. Van Erven, P. E. Bloch Thomsen, M. P. Lopez Chicharro, O. Merhi, Y. Soga, K. Andou, M. Nobuyoshi, A. Gonzalez-Mansilla, R. Martin-Asenjo, L. Unzue, J. Torres, E. Garralda, R. R. Coma, J. E. Rodriguez Garcia, T. Yaegashi, H. Furusho, T. Kato, A. Chikata, S. Takashima, S. Usui, M. Takamura, S. Kaneko, M. Chudzik, P. Mitkowski, A. Przybylski, J. Lewek, T. Smukowski, A. Maciag, S. Castrejon Castrejon, A. Perez-Silva, A. Estrada, D. Doiny, M. Ortega, J. L. Lopez-Sendon, J. L. Merino, C. O'mahony, C. Coats, M. Cardona, A. Garcia, M. Calcagnino, R. Lachmann, D. Hughes, P. M. Elliott, S. Conti, G. P. Pruiti, E. Puzzangara, S. A. Romano, A. Di Grazia, G. P. Ussia, C. Tamburino, V. Calvi, A. Radinovic, S. Sala, A. Latib, M. Mussardo, S. Sora, G. Paglino, M. Gullace, A. Colombo, M.- A. G. Ohlow, B. Lauer, A. Wagner, M. Schreiber, B. Buchter, A. Farah, J. T. Fuhrmann, J. C. Geller, R. M. Nascimento Cardoso, L. A. Batista Sa, L. F. C. Campos Filho, S. V. Rodrigues, M. V. F. Dutra, T. R. S. A. Borges, D. R. Portilho, T. Deering, A. Bernardes, A. Veiga, O. Gartenlaub, A. Goncalves, A. Jimenez, A. Rousseauplasse, J. C. Deharo, H. Striekwold, G. Gosselin, H. Sitbon, V. Martins, G. Molon, F. Ayala-Paredes, M. J. Sancho-Tello, I. A. Fazal, S. Brady, J. Cronin, S. Mcnally, M. Tynan, C. J. Plummer, J. M. Mccomb, J. E. Val-Mejias, R. M. Oliveira, R. Costa, M. Martinelli Filho, K. R. Silva, L. M. Menezes, W. T. Tamaki, W. Mathias, N. A. G. Stolf, T. Misawa, I. Ohta, T. Shishido, T. Miyasita, T. Miyamoto, J. Nitobe, T. Watanabe, I. Kubota, B. Thibault, A. Ducharme, C. Simpson, C. Stuglin, C. E. Gagne, R. Williams, S. Mcnicoll, M. S. Silvetti, F. Drago, D. Penela, B. Bijnens, A. Doltra, E. Silva, A. Berruezo, L. Mont, M. Sitges, R. Mcintosh, O. Baumann, P. Raju, S. Gurunathan, S. Furniss, N. Patel, N. Sulke, G. Lloyd, M. Mor, S. Dror, Y. Tsadok, N. Bachner-Hinenzon, A. Katz, N. Liel-Cohen, Y. Etzion, R. Mlynarski, A. Mlynarska, J. Wilczek, M. Sosnowski, A. M. Sinha, D. Sinha, G. Noelker, J. Brachmann, F. Weidemann, G. Ertl, M. Jones, N. Searle, M. Cocker, E. Ilsley, P. Foley, R. Khiani, K. E. Nelson, A. J. Turley, W. A. Owens, S. A. James, N. J. Linker, V. Velagic, M. Cikes, B. Pezo Nikolic, D. Puljevic, J. Separovic-Hanzevacki, M. Lovric-Bencic, B. Biocina, D. Milicic, H. Kawata, L. Chen, H. Phan, K. Anand, G. Feld, U. Birgesdotter-Green, I. Fernandez Lozano, C. Mitroi, J. Toquero Ramos, V. Castro Urda, V. Monivas Palomero, A. Corona Figueroa, L. Hernandez Reina, L. Alonso Pulpon, A. Gate-Martinet, A. Da Costa, P. Rouffiange, A. Cerisier, L. Bisch, C. Romeyer-Bouchard, K. Isaaz, M.- A. Morales, E. Bianchini, U. Startari, F. Faita, T. Bombardini, V. Gemignani, M. Piacenti, S. Adhya, R. H. Kamdar, L. M. Millar, C. Burchardt, F. D. Murgatroyd, D. Klug, C. Kouakam, L. Guedon-Moreau, C. Marquie, S. Benard, S. Kacet, N. Cortez-Dias, P. Carrilho-Ferreira, D. Silva, S. Goncalves, M. Valente, P. Marques, L. Carpinteiro, J. Sousa, T. Keida, T. Nishikido, M. Fujita, T. Chinen, T. Kikuchi, K. Nakamura, H. Ohira, M. Takami, D. Anjo, A. Meireles, C. Gomes, C. Roque, A. Pinheiro Vieira, V. Lagarto, H. Reis, S. Torres, D. F. Ortega, L. D. Barja, J. P. Montes, E. Logarzo, P. Bonomini, N. Mangani, C. Paladino, T. Chwyczko, E. Smolis-Bak, M. Sterlinski, M. Pytkowski, B. Firek, A. Jankowska, H. Szwed, I. Nakajima, T. Noda, H. Okamura, K. Satomi, T. Aiba, W. Shimizu, N. Aihara, S. Kamakura, W. Brzozowski, A. Tomaszewski, A. Wysokinski, E. G. Bertoldi, L. E. Rohde, L. I. Zimerman, M. Pimentel, C. A. Polanczyk, G. Boriani, M. Lunati, M. Gasparini, M. Landolina, G. Lonardi, D. Pecora, M. Santini, S. Valsecchi, B. J. Rubinstein, D. Y. Wang, S. E. Cabreriza, M. E. Richmond, A. Rusanov, T. A. Quinn, B. Cheng, H. M. Spotnitz, H. M. Kristiansen, G. Vollan, T. Hovstad, H. Keilegavlen, S. Faerestrand, U. Brigesdotter-Green, A. M. R. Nawar, D. A. L. I. A. Ragab, R. A. N. I. A. Eluhsseiny, A. H. M. E. D. Abdelaziz, E. Nof, R. Abu Shama, J. Buber, R. Kuperstein, M. S. Feinberg, D. Barlev, M. Eldar, M. Glikson, H. Badran, R. Samir, M. Tawfik, M. Amin, H. Eldamnhoury, S. Khaled, J. M. Tolosana, A. M. Martin, A. Hernandez-Madrid, A. Macias, I. Fernandez-Lozano, J. Osca, A. Quesada, L. Padeletti, G. L. Botto, T. De Santo, A. Szwed, J. G. Martinez, B. Degand, G. Q. Villani, C. Leclercq, P. Ritter, I. Watanabe, K. Nagashima, Y. Okumura, M. Kofune, K. Ohkubo, T. Nakai, A. Hirayama, E. Mikhaylov, M. Vander, D. Lebedev, M. Zarse, H. Suleimann, H. Bogossian, J. Stegelmeyer, I. Ninios, Z. Karosienne, A. Kloppe, B. Lemke, S. John, T. Gaspar, S. Rolf, P. Sommer, G. Hindricks, C. Piorkowski, J. Fernandez-Armenta, L. L. Mont, H. Zeljko, D. Andreu, C. Herzcku, T. Boussy, J. Brugada, T. Obayahi, J. Hegrenes, E. Lim, V. Mediratta, R. Bautista, L. Teplitsky, C. F. B. Van Huls Van Taxis, A. P. Wijnmaalen, M. Gawrysiak, J. D. Schuijf, J. J. Bax, Y. Huo, S. Richter, A. Arya, A. Bollmann, F. Akca, T. Bauernfeind, B. Schwagten, N. M. S. De Groot, L. Jordaens, T. Szili-Torok, S. Miller, G. Kastner, P. Maury, P. Della Bella, E. Delacretaz, F. Sacher, G. Maccabelli, R. Brenner, A. Rollin, P. Jais, P. Vergara, N. Trevisi, A. Ricco, F. Petracca, C. Bisceglia, F. Baratto, R. Salguero Bodes, A. Fontenla Cerezuela, M. De Riva Silva, M. Lopez Gil, E. Mejia Martinez, A. Jurado Roman, M. Montero Alvarez, F. Arribas Ynsaurriaga, A. Baszko, K. Krzyzanowski, W. Bobkowski, R. Surmacz, E. Zinka, A. Siwinska, A. Szyszka, A. Perez Silva, A. Estrada Mucci, M. Ortega Molina, J. L. Lopez Sendon, J. L. Merino Llorens, K. Kaitani, K. Hanazawa, C. Izumi, Y. Nakagawa, I. Yamanaka, T. Hirahara, Y. Sugawara, C. Suga, J. Ako, S. Momomura, N. Galizio, J. Gonzalez, F. Robles, A. Palazzo, L. Favaloro, M. Diez, E. Guevara, A. Fernandez, S. Greenberg, A. Epstein, D. S. Goldman, C. Sangli, J. A. Keeney, K. Lee, S. R. D. Piers, J. B. Van Rees, J. Thijssen, C. J. W. Borleffs, E. T. Van Der Velde, C. H. Leclercq, M. Hero, M. Mizobuchi, Y. Enjoji, Y. Yazaki, K. Shibata, A. Funatsu, T. Kobayashi, S. Nakamura, G. Amit, B. Pertzov, D. Zahger, L. Medesani, R. Rana, F. Albano, H. Fraguas, S. S. Pedersen, M. T. Hoogwegt, D. A. M. J. Theuns, K. C. Van Den Broek, F. B. Tekle, M. Habibovic, M. Alings, P. Van Der Voort, J. Denollet, H. Vrazic, C. Jilek, H. Lesevic, S. Tzeis, V. Semmler, M. R. Gold, M. C. Burke, G. H. Bardy, N. Varma, B. Pavri, B. Stambler, J. Michalski, T. R. U. S. T. Investigators, E. Safak, D. Schmitz, T. Konorza, C. Wende, A. Schirdewan, J. Neuzner, T. Simmers, A. Erglis, R. Gradaus, J. Goetzke, L. Coutrot, K. Goehl, V. Bazan Gelizo, N. Grau, E. Valles, M. Felez, C. Sanjuas, J. Bruguera, J. Marti-Almor, S. Y. Chu, P. W. Li, W. H. Ding, C. Schukro, L. Leitner, J. Siebermair, G. Stix, T. Pezawas, J. Kastner, M. Wolzt, H. Schmidinger, N. A. T. H. A. L. I. E. Behar, G. Kervio, B. Petit, P. Maison-Balnche, S. Bodi, P. Mabo, P. W. X. Foley, E. Mutch, J. Brashaw-Smith, L. Ball, F. Leyva, D. H. Kim, M. J. Lee, W. S. Lee, S. D. Park, S. H. Shin, S. I. Woo, J. Kwan, K. S. Park, Y. Munetsugu, K. Tanno, M. Kikuchi, H. Ito, F. Miyoshi, M. Kawamura, Y. Kobayashi, S. Man, A. M. Algra, C. A. Schreurs, E. E. Van Der Wall, S. C. Cannegieter, C. A. Swenne, K. Iitsuka, T. Kondo, K. Goebbert, Z. Karossiene, D. Goldman, B. Kallen, E. Kerpi, J. Sardo, P. Arsenos, K. Gatzoulis, G. Manis, P. Dilaveris, D. Tsiachris, D. Mytas, S. Asimakopoulos, C. Stefanadis, S. Sideris, E. Kartsagoulis, O. Barbosa, M. Marocolo Junior, R. Silva Cortes, R. A. Moraes Brandolis, L. F. Oliveira, L. A. Pertili Rodrigues De Resende, M. A. Vieira Da Silva, V. J. Dias Da Silva, R. A. Hegazy, I. A. Sharaf, F. Fadel, H. Bazaraa, R. Esam, M. S. Deshko, V. A. Snezhitsky, T. P. Stempen, K. Kuroki, M. Igawa, K. Kuga, L. Ferreira Santos, T. Dionisio, L. Nunes, J. Machado, S. Castedo, C. Henriques, A. Matos, J. Oliveira Santos, K. Kraaier, M. A. G. M. Olimulder, M. A. Galjee, P. F. H. M. Van Dessel, J. Van Der Palen, A. A. M. Wilde, M. F. Scholten, F. Chouchou, L. Poupard, C. Philippe, I. Court-Fortune, J.- C. Barthelemy, F. Roche, T. S. Dolgoshey, G. A. Madekina, S. Sugiura, E. Fujii, M. Senga, K. Dohi, E. Sugiura, M. Nakamura, M. Ito, C. Eitel, J. Mendell, K. Lasseter, M. Shi, L. Urban, R. Hatala, P. Hlivak, M. De Melis, C. Garutti, G. Corbucci, H. Mlcochova, R. Maxian, E. Arbelo, A. Dogac, C. Luepkes, M. Ploessnig, C. Chronaki, L. Hinterbuchner, A. Guillen, S. S. Bun, D. G. Latcu, F. Franceschi, S. Prevot, L. Koutbi, P. Ricard, N. Saoudi, N. Nazari, A. Alizadeh, S. Sayah, M. Hekmat, M. Assadian, A. Ahmadzadeh, M. Wnuk, J. Jedrzejczyk-Spaho, O. Kruszelnicka, W. Piwowarska, A. Fedorowski, P. Burri, S. Juul-Moller, O. Melander, P. Mitro, P. Murin, P. Kirsch, V. Habalova, E. Slaba, E. Matyasova, M. A. Barlow, R. J. Blake, P. Rostoff, E. Wojewodka Zak, L. Froidevaux, F. P. Sarasin, M. Louis-Simonet, O. Hugli, B. Yersin, J. Schlaepfer, C. Mischler, E. Pruvot, E. Occhetta, F. Frascarelli, A. Burali, and E. Dovellini
Subjects: Oncology, medicine.medical_specialty, business.industry, nutritional and metabolic diseases, medicine.disease, Logistic regression, Breast cancer, Physiology (medical), Internal medicine, medicine, lipids (amino acids, peptides, and proteins), skin and connective tissue diseases, Cardiology and Cardiovascular Medicine, business
Abstract: Results: Out of 664159 women there were 22938 patients with hyperlipidaemia (3.5%) and 9312 patients with breast cancer. Out of the hyperlipidaemia patients, 530 patients developed breast cancer (2.3%) compared with 8782 patients developing breast cancer without hyperlipidaemia (1.4%). A logistic regression model accounting for time from first presentation to development of breast cancer showed that the presence of hyperlipidaemia increases the outcome of breast cancer by 1.64 times (95% C.I. 1.50-1.79). Conclusions: Whilst we appreciate numerous limitations of our methods, coupled with the main findings of the recent basic science research, our analysis further augments the case for the role of cholesterol in the development of breast cancer. Our data from a large clinical relevant sample further strengthens the argument to prospectively trial statins in the management of breast cancer.
Published: 2011

30. Magnetic and structural properties of Co2FeAl1−xSixthin films

Author: E. Arbelo Jorge, H. J. Elmers, P. Klaer, Martin Jourdan, and M. Kallmayer
Subjects: History, Magnetization, Materials science, Reflection high-energy electron diffraction, Condensed matter physics, X-ray magnetic circular dichroism, Electron diffraction, Spin polarization, Magnetic circular dichroism, Annealing (metallurgy), Dichroism, Computer Science Applications, Education
Abstract: We investigate different types of disorder which are predicted to influence the spin polarization by x-ray and electron diffraction (RHEED). We observe that the compound Co2FeAl grows in the B2 ordered structure. However, for Co2FeAl0.3Si0.7 the analysis revealed with increasing annealing temperature a crossover from B2 to L21 order. The magnetization of the samples is investigated by SQUID magnetometry and x-ray magnetic circular dichroism (XMCD) experiments in bulk sensitive transmission and surface sensitive total electron yield (TEY) mode. The results reveal the same surface and bulk moments of Co2FeAl. However, with increasing annealing temperature the Co2FeAl0.3Si0.7 thin films display a small decrease of the surface moment in contrast to a not changing bulk moment. This observation is relevant concerning potential device applications of Co2FeAl0.3Si0.7.
Published: 2010

31. Abstracts: Cardiac resynchronisation therapy: results and mechanisms

Author: Stefan D. Anker, B. Hamilton, E. Jetton, Wolfram Doehner, N. Pezzali, T. A. Charlton, E. J. Johnson, Loredana Covolo, Fiorella Donato, E. Caballero Dorta, A. Oza, E. Arbelo Lainez, Peter Thomas Mortensen, M. Metra, A. Medina Fernandez-Aceytuno, Oezlem Celebi, M. Diaz Escofet, K. Toluie, Andi Eie Albertsen, C. Rios Diaz, B. Moreno Djadou, L. Dei Cas, Sandra B. Charlton, A. Garcia Quintana, Mads Brix Kronborg, Suzanne Fateh-Moghadam, Umberto Gelatti, Rainer Dietz, S. Chandiramani, D. Sterns, Jc. Nielsen, Martin Stockburger, Antonio Curnis, Jason Sims, M. Missorici Corso, M. A. Coppess, J. C. Barnett, Tim Karhausen, F. A. Mcgrew, and Aischa Nitardy
Subjects: medicine.medical_specialty, business.industry, Physiology (medical), medicine, Cardiology and Cardiovascular Medicine, Intensive care medicine, business
Published: 2009

32. Poster Session 4: ECG

Author: D. Rollando, R. Pap, F. Fernandez-Aviles, N. Davidson, R. Weber, A. H. Christensen, E. Stoica, G. P. Bezante, P. Saravanan, A. Tardin, S. Apiyasawat, T. Papaioannou, L. Getaz, F. Gonzalez Llopis, G. Bertero, B. Moise, L. Paredes, A. Antoniadis, C. Stefanadis, J. Osca Asensi, M. Haissaguerre, A. Forclaz, P. Serrano Aguilar, M. Trusz-Gluza, E. Tsaritsaniotis, I. Nault, E. Arbelo Lainez, A. Matsumura, A. Filipecki, P. Dilaveris, J. L. Rojo Alvarez, T. Forster, M. Ito, J. A. Giner-Caro, J. Martinez-Sanchez, J. H. Svendsen, S. Yamazato, Everss, E. Modonesi, M. Suzuki, J. Carlson, K. Letsas, S. Sugiura, J. D. Luporsi, R. M. W. Hofstra, F. Holmqvist, P. Kaminsky, A. Bikias, S. O'neill, S. Led, E. Themeles, Y. Jackson, D. Coriu, A. Salvador Sanz, J. J. Sanchez-Munoz, T. Arentz, E. Gonzalez-Torrecilla, E. Reppas, F. Chappuis, G. Tsiliki, O. Chioncel, G. Katsaris, M. Senga, G. Manis, T. H. Beleveslis, L. Haman, A. Michelucci, Z. Tabor, J. Sztajzel, A. Jadidi, K. Tsakiridis, M. Kotsakou, C. Militaru, S. Haunso, S. Archontakis, C. Macarie, F. Atienza Fernandez, M. Nieri, A. Makai, K. Wita, P. Reilly, E. Fujii, I. Donoiu, P. Chandanamattha, M. Ezekowitz, S. Connolly, G. Moschos, G. Galanti, J. D. H. Jongbloed, H. Dostalova, M. Hocini, O. Cano Perez, J. Olague De Ros, S. Yusuf, A. Scopinaro, S. Sideris, A. Arenal Maiz, S. Terrades, E. Zorio Grima, L. Caselli, A. Garcia Quintana, M. Gatley, J. Oldgren, S. Miyazaki, I. Delithanasis, N. Fragakis, I. Tatsis, E. Hatzinikolaou-Kotsakou, M. Wright, J. Navarro Manchon, A. Giuca, L. Garcia Perez, M. L. Castilla San Jose, P. Penafiel-Verdu, S. Narayan, T. Gialernios, E. Caballero Dorta, A. Barsotti, D. D. Ionescu, M. Valdes-Chavarri, C. Brunelli, A. Garcia-Alberola, G. Klausz, T. Ngarmukos, J. Almendral Garrote, O. Londono Sanchez, B. Brembilla-Perrot, M. Nakamura, L. Wallentin, M. A. Arnau Vives, J. Gaspoz, Y. Hashimoto, P. Van Der Zwaag, K. Szydlo, G. Bencsik, F. J. Pastor-Perez, P. Parizek, P. G. Platonov, S. Vignini, M. P. Van Den Berg, V. Santeladze, P. Arsenos, K. Gatzoulis, K. Likittanasombat, M. Ohno, L. Saghy, A. Medina Fernandez-Aceytuno, W. Nagahori, D. Kalusche, L. Serrano Arriezu, A. Parekh, N. N. Al-Shawabkeh, J P Van Tintelen, K. Astheimer, M. Stridh, and N. Sadoul
Subjects: medicine.medical_specialty, business.industry, Physiology (medical), Physical therapy, medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published: 2009

33. Morphology and magnetoresistance of Co2Cr0.6Fe0.4Al-based tunnelling junctions

Author: C. Herbort, Martin Jourdan, and E Arbelo
Subjects: Reflection high-energy electron diffraction, Materials science, Acoustics and Ultrasonics, Condensed matter physics, Metallurgy, Sputter deposition, Condensed Matter Physics, Epitaxy, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, Tunnel magnetoresistance, law, Sputtering, Scanning tunneling microscope, Thin film, Quantum tunnelling
Abstract: Some ferromagnetic Heusler compounds are theoretically predicted to be half metallic materials, i.e. to be characterized by a huge spin polarization at the Fermi energy. We investigate the correlations between junction preparation conditions, morphology and transport properties of planar MgO/Co2Cr0.6Fe0.4Al/AlOx/Co/CoOx/Pt tunnelling junctions. Epitaxial Co2Cr0.6Fe0.4Al thin films were deposited by dc and rf magnetron sputtering on different buffer layers (Cr, Fe, MgO) on MgO(1 0 0) substrates. By RHEED, LEED and in situ STM investigations different surface morphologies were observed. Atomically flat surfaces with Co2Cr0.6Fe0.4Al unit cell sized steps (B2 structure) were obtained by rf sputtering on MgO substrates with e-beam evaporated MgO buffer layers. However, this morphology results in AlOx tunnelling barriers with improper wetting properties.
Published: 2009

34. Laser irradiation in Nd3+ doped strontium barium niobate glass

Author: J.M. Cáceres, Inocencio R. Martín, E. Arbelo-Jorge, P. Núñez, S. González-Pérez, and Patricia Haro-González
Subjects: Materials science, Glass-ceramic, business.industry, General Physics and Astronomy, Mineralogy, chemistry.chemical_element, Strontium barium niobate, Laser, Neodymium, Nanocrystalline material, law.invention, chemistry.chemical_compound, chemistry, law, visual_art, visual_art.visual_art_medium, Optoelectronics, Ceramic, Irradiation, business, Glass transition
Abstract: A local nanocrystalline formation in a neodymium doped strontium barium niobate (SBN) glass has been obtained under argon laser irradiation. The intense emission around 880 nm, originated from the F43/2 (F45/2) thermalized level when the glass structure changes to a glass ceramic structure due to the irradiation of the laser beam, has been studied. The intensities and lifetimes change from this level inside and outside the irradiated area made by the laser excitation. They have been analyzed and demonstrated that the desvitrification process has been successfully achieved. These results confirm that nanocrystals of SBN have been created by the laser action confirming that the transition from glass to glass ceramic has been completed. These results are in agreement with the emission properties of nanocrystals of the bulk glass ceramic sample. The present study also suggests that the SBN nanocrystal has a potential application as temperature detector.
Published: 2008

35. 920 Echocardiographic cardiac remodelling in patients with atrial fibrillation and cardiac resynchronization therapy

Author: J. Suarez De Lezo, Angel Medina, A. Garcia Quintana, J.R. Ortega Trujillo, M. Diaz Escofet, C. Amador Gil, E. Arbelo Lainez, and N. Castro Bueno
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Cardiac resynchronization therapy, Atrial fibrillation, General Medicine, medicine.disease, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, In patient, Cardiology and Cardiovascular Medicine, business
Published: 2006

36. 1011 Echocardiography improvement with cardiac resynchronization in patients with chronic right ventricular pacing

Author: A. Medina Fernandez-Aceytuno, J. Suarez De Lezo, E. Arbelo Lainez, C. Amador Gil, E. Hernandez Ortega, J.R. Ortega Trujillo, E. Caballero Dorta, and A. Garcia Quinlana
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Cardiac resynchronization therapy, General Medicine, Ventricular pacing, Internal medicine, Cardiac resynchronization, Cardiology, medicine, Radiology, Nuclear Medicine and imaging, In patient, Cardiology and Cardiovascular Medicine, business
Published: 2005

37. 537 Early echocardiographic remodelling with cardiac resynchronization in patients with aortic prosthesis and ventricular dysfunction

Author: A. Delgado Espinosa, E. Caballero Dorta, E. Arbelo Lainez, P. Martin, A. Medina Fernandez-Aceytuno, M. Diaz Escofet, A. Garcia Quintana, and J.R. Ortega Trujillo
Subjects: Aorta, medicine.medical_specialty, business.industry, General Medicine, Aortic prosthesis, medicine.artery, Internal medicine, Cardiac resynchronization, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, In patient, Cardiology and Cardiovascular Medicine, business
Published: 2005

38. 460 Simplified semiquantitative assessment of asynchrony and resynchronization with color tissue Doppler

Author: E. Hernandez Ortega, C. Amador Gil, A. Garcia Quintana, A. Medina Fernandez-Aceytuno, J.R. Ortega Trujillo, N. Castro Bueno, P. Gil Padron, and E. Arbelo Lainez
Subjects: medicine.medical_specialty, business.industry, Color tissue, General Medicine, Asynchrony (computer programming), symbols.namesake, Internal medicine, medicine, symbols, Cardiology, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Doppler effect
Published: 2005

39. Magnetic and structural properties of Co2FeAl1−xSix thin films.

Author: Jorge, E. Arbelo, Jourdan, M., Kallmayer, M., Klaer, P., and Elmers, H-J
Published: 2010
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40. Personalized voltage maps guided by cardiac magnetic resonance in the era of high-density mapping.

Author: Vázquez-Calvo S, Garre P, Ferró E, Sánchez-Somonte P, Guichard JB, Falzone PV, Guasch E, Porta-Sánchez A, Tolosana JM, Borras R, Arbelo E, Ortiz-Pérez JT, Prats S, Perea RJ, Brugada J, Mont L, and Roca-Luque I
Subjects: Humans, Male, Female, Aged, Catheter Ablation methods, Heart Conduction System physiopathology, Middle Aged, Body Surface Potential Mapping methods, Electrophysiologic Techniques, Cardiac methods, Tachycardia, Ventricular physiopathology, Tachycardia, Ventricular diagnosis, Magnetic Resonance Imaging, Cine methods
Abstract: Background: Voltage mapping could identify the conducting channels potentially responsible for ventricular tachycardia (VT). Standard thresholds (0.5-1.5 mV) were established using bipolar catheters. No thresholds have been analyzed with high-density mapping catheters. In addition, channels identified by cardiac magnetic resonance (CMR) has been proven to be related with VT., Objective: The purpose of this study was to analyze the diagnostic yield of a personalized voltage map using CMR to guide the adjustment of voltage thresholds., Methods: All consecutive patients with scar-related VT undergoing ablation after CMR (from October 2018 to December 2020) were included. First, personalized CMR-guided voltage thresholds were defined systematically according to the distribution of the scar and channels. Second, to validate these new thresholds, a comparison with standard thresholds (0.5-1.5 mV) was performed. Tissue characteristics of areas identified as deceleration zones (DZs) were recorded for each pair of thresholds. In addition, the relation of VT circuits with voltage channels was analyzed for both maps., Results: Thirty-two patients were included [mean age 66.6 ± 11.2 years; 25 (78.1%) ischemic cardiomyopathy]. Overall, 52 DZs were observed: 44.2% were identified as border zone tissue with standard cutoffs vs 75.0% using personalized voltage thresholds (P = .003). Of the 31 VT isthmuses detected, only 35.5% correlated with a voltage channel with standard thresholds vs 74.2% using adjusted thresholds (P = .005). Adjusted cutoff bipolar voltages that better matched CMR images were 0.51 ± 0.32 and 1.79 ± 0.71 mV with high interindividual variability (from 0.14-1.68 to 0.7-3.21 mV)., Conclusion: Personalized voltage CMR-guided personalized voltage maps enable a better identification of the substrate with a higher correlation with both DZs and VT isthmuses than do conventional voltage maps using fixed thresholds., Competing Interests: Disclosures Drs Mont and Brugada report activities as a consultant, lecturer, and advisory board member for Abbott Medical, Boston Scientific, Biosense Webster, Medtronic, and Biotronik. They are also shareholders of ADAS 3D Medical. Drs Roca-Luque, Tolosana, and Porta-Sánchez report activities as a consultant and lecturer for Biosense Webster, Medtronic, Boston Scientific, and Abbott Medical. All other authors report that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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41. Longitudinal comparison of dyssynchrony correction and 'strain' improvement by conduction system pacing: LEVEL-AT trial secondary findings.

Author: Pujol-López M, Jiménez-Arjona R, Garcia-Ribas C, Borràs R, Guasch E, Regany-Closa M, Graterol FR, Niebla M, Carro E, Roca-Luque I, Guichard JB, Castel MÁ, Arbelo E, Porta-Sánchez A, Brugada J, Sitges M, Tolosana JM, Doltra A, and Mont L
Subjects: Humans, Female, Male, Aged, Middle Aged, Treatment Outcome, Echocardiography, Heart Failure therapy, Heart Failure physiopathology, Heart Failure diagnostic imaging, Stroke Volume physiology, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left therapy, Ventricular Dysfunction, Left physiopathology, Longitudinal Studies, Follow-Up Studies, Cardiac Resynchronization Therapy methods
Abstract: Aims: Longitudinal dyssynchrony correction and 'strain' improvement by comparable cardiac resynchronization therapy (CRT) techniques is unreported. Our purpose was to compare echocardiographic dyssynchrony correction and 'strain' improvement by conduction system pacing (CSP) vs. biventricular pacing (BiVP) as a marker of contractility improvement during 1-year follow-up., Methods and Results: A treatment-received analysis was performed in patients included in the LEVEL-AT trial (NCT04054895), randomized to CSP or BiVP, and evaluated at baseline (ON and OFF programming) and at 6 and 12 months (n = 69, 32% women). Analysis included intraventricular (septal flash), interventricular (difference between left and right ventricular outflow times), and atrioventricular (diastolic filling time) dyssynchrony and 'strain' parameters [septal rebound, global longitudinal 'strain' (GLS), LBBB pattern, and mechanical dispersion). Baseline left ventricular ejection fraction (LVEF) was 27.5 ± 7%, and LV end-systolic volume (LVESV) was 138 ± 77 mL, without differences between groups. Longitudinal analysis showed LVEF and LVESV improvement (P < 0.001), without between-group differences. At 12-month follow-up, adjusted mean LVEF was 46% with CSP (95% CI 42.2 and 49.3%) vs. 43% with BiVP (95% CI 39.6 and 45.8%), (P = 0.31), and LVESV was 80 mL (95% CI 55.3 and 104.5 mL) vs. 100 mL (95% CI 78.7 and 121.6 mL), respectively (P = 0.66). Longitudinal analysis showed a significant improvement of all dyssynchrony parameters and GLS over time (P < 0.001), without differences between groups. Baseline GLS significantly correlated with LVEF and LVESV at 12-month follow-up., Conclusion: CSP and BiVP provided similar dyssynchrony and 'strain' correction over time. Baseline global longitudinal 'strain' predicted ventricular remodelling at 12-month follow-up., Competing Interests: Conflict of interest: M.P.-L. has received speaker honoraria from Medtronic. J.M.T. has received honoraria as a lecturer and consultant from Abbott, Boston Scientific, and Medtronic. L.M. has received unrestricted research grants, fellowship programme support, and honoraria as a lecturer and consultant from Abbott, Biotronik, Boston Scientific, Livanova, and Medtronic; he holds stock in Galgo Medical and Corify. I.R.-L. has received honoraria as a lecturer and consultant from Abbott and Biosense Webster. M.S. has received consultant fees and speaker honoraria from Abbott, Medtronic, General Electric, and Edwards Lifesciences. M.A.C. has received speaker honoraria from Boston Scientific, Abbott, and Microport. E.A. has received speaker honoraria from Biosense Webster and Bayer. A.P.-S. has received honoraria as a lecturer and consultant from Biosense Webster, Abbott, and Boston Scientific. All remaining authors have declared no conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Published: 2024
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42. The European Society of Cardiology quality indicators in atrial fibrillation in centers of excellence in Spain: the SEC-EXCELENTE FA registry.

Author: Ruiz Ortiz M, Arbello Laínez E, Roldán Rabadán I, Marín F, Pérez Cabeza A, Marzoa Rivas R, Peinado Peinado R, Valle Alberca A, Ibáñez Criado A, Valle Muñoz A, Osca Asensi J, Del Río Lechuga A, Elola Somoza FJ, Anguita Sánchez M, Ruiz Ortiz M, Peinado Peinado R, Arbelo Laínez E, Valle Alberca A, Ibáñez Criado A, Valle Muñoz A, Osca Asensi J, Río Lechuga AD, and Pérez Cabeza AI
Abstract: Introduction and Objectives: By 2022, 9 centers had been accredited by the Spanish Society of Cardiology for the atrial fibrillation (AF) process. Our objective was to evaluate the performance of these centers based on the quality indicators (QIs) proposed by the European Society of Cardiology (ESC) in 2020., Methods: Adults with AF who were attended in the cardiology departments of participating centers during the second week of May 2019 were included in a retrospective registry (n=797, age 72±11 years, 60% male). Key ESC QIs were assessed., Results: CHA 2 DS 2 -VASc, HAS-BLED scores, and serum creatinine levels were documented in 24.9%, 6.1%, and 96.2% of patients, respectively. Anticoagulation was appropriately prescribed in 90.6% of high-risk patients according to the CHA 2 DS 2 -VASc score, but was inappropriately prescribed in 57.8% of low-risk patients. Among all patients, 84.1% received high-quality anticoagulation. Inappropriate antiarrhythmic drugs were prescribed in 7.2% of patients with permanent AF, 2.9% of those with structural heart disease, and 0.0% of those with end-stage kidney disease. Catheter ablation was offered to 70% of patients with symptomatic paroxysmal or persistent AF after the failure or intolerance of 1 antiarrhythmic drug. All modifiable risk factors were documented in 59.3% of patients. Rates of all-cause mortality, ischemic stroke or transient ischemic attack, and major bleeding were 8.1, 0.8, and 2.56 per 100 patients/y, respectively. QIs for anticoagulation and outcomes were similar between general cardiology and tertiary referral centers., Conclusions: Although accredited centers in Spain demonstrated good performance in many of the ESC QIs for AF, there remains room for improvement. These data could serve as a starting point for enhancing the quality of care in this population., (Copyright © 2024 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)
Published: 2024
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43. Clinical and economic impact of first-line or drug-naïve catheter ablation and delayed second-line catheter ablation for atrial fibrillation using a patient-level simulation model.

Author: Arbelo E, Ponti R, Cohen L, Pastor L, Costa G, Hempel M, and Grima D
Abstract: Aims: To determine the clinical and economic implications of first-line or drug-naïve catheter ablation compared to antiarrhythmic drugs (AADs), or shorter AADs-to-Ablation time (AAT) in atrial fibrillation (AF) patients in France and Italy, using a patient level-simulation model., Materials and Methods: A patient-level simulation model was used to simulate clinical pathways for AF patients using published data and expert opinion. The probabilities of adverse events (AEs) were dependent on treatment and/or disease status. Analysis 1 compared scenarios of treating 0%, 25%, 50%, 75% or 100% of patients with first-line ablation and the remainder with AADs. In Analysis 2, scenarios compared the impact of delaying transition to second-line ablation by 1 or 2 years., Results: Over 10 years, increasing first-line ablation from 0% to 100% (versus AAD treatment) decreased stroke by 12%, HF hospitalization by 29%, and cardioversions by 45% in both countries. As the rate of first-line ablation increased from 0% to 100%, the overall 10-year per-patient costs increased from €13,034 to €14,450 in Italy and from €11,944 to €16,942 in France. For both countries, the scenario with no delay in second-line ablation had fewer AEs compared to the scenarios where ablation was delayed after AAD failure. Increasing rates of first-line or drug-naïve catheter ablation, and shorter AAT, resulted in higher cumulative controlled patient years on rhythm control therapy., Limitations: The model includes assumptions based on the best available clinical data, which may differ from real-world results, however, sensitivity analyses were included to combat parameter ambiguity. Additionally, the model represents a payer perspective and does not include societal costs, providing a conservative approach., Conclusion: Increased first-line or drug-naïve catheter ablation, and shorter AAT, could increase the proportion of patients with controlled AF and reduce AEs, offsetting the small investment required in total AF costs over 10 years in Italy and France.
Published: 2024
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44. Regional conduction velocities determined by noninvasive mapping are associated with arrhythmia-free survival after atrial fibrillation ablation.

Author: Invers-Rubio E, Hernández-Romero I, Reventos-Presmanes J, Ferro E, Guichard JB, Regany-Closa M, Pellicer-Sendra B, Borras R, Prat-Gonzalez S, Tolosana JM, Porta-Sanchez A, Arbelo E, Guasch E, Sitges M, Brugada J, Guillem MS, Roca-Luque I, Climent AM, Mont L, and Althoff TF
Subjects: Humans, Male, Female, Middle Aged, Prospective Studies, Electrocardiography, Heart Atria physiopathology, Heart Atria diagnostic imaging, Follow-Up Studies, Magnetic Resonance Imaging, Cine methods, Recurrence, Aged, Body Surface Potential Mapping methods, Electrophysiologic Techniques, Cardiac methods, Atrial Fibrillation physiopathology, Atrial Fibrillation surgery, Catheter Ablation methods, Heart Conduction System physiopathology, Pulmonary Veins surgery, Pulmonary Veins physiopathology, Pulmonary Veins diagnostic imaging
Abstract: Background: Atrial arrhythmogenic substrate is a key determinant of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI), and reduced conduction velocities have been linked to adverse outcome. However, a noninvasive method to assess such electrophysiologic substrate is not available to date., Objective: This study aimed to noninvasively assess regional conduction velocities and their association with arrhythmia-free survival after PVI., Methods: A consecutive 52 patients scheduled for AF ablation (PVI only) and 19 healthy controls were prospectively included and received electrocardiographic imaging (ECGi) to noninvasively determine regional atrial conduction velocities in sinus rhythm. A novel ECGi technology obviating the need of additional computed tomography or cardiac magnetic resonance imaging was applied and validated by invasive mapping., Results: Mean ECGi-determined atrial conduction velocities were significantly lower in AF patients than in healthy controls (1.45 ± 0.15 m/s vs 1.64 ± 0.15 m/s; P < .0001). Differences were particularly pronounced in a regional analysis considering only the segment with the lowest average conduction velocity in each patient (0.8 ± 0.22 m/s vs 1.08 ± 0.26 m/s; P < .0001). This average conduction velocity of the "slowest" segment was independently associated with arrhythmia recurrence and better discriminated between PVI responders and nonresponders than previously proposed predictors, including left atrial size and late gadolinium enhancement (magnetic resonance imaging). Patients without slow-conduction areas (mean conduction velocity <0.78 m/s) showed significantly higher 12-month arrhythmia-free survival than those with 1 or more slow-conduction areas (88.9% vs 48.0%; P = .002)., Conclusion: This is the first study to investigate regional atrial conduction velocities noninvasively. The absence of ECGi-determined slow-conduction areas well discriminates PVI responders from nonresponders. Such noninvasive assessment of electrical arrhythmogenic substrate may guide treatment strategies and be a step toward personalized AF therapy., Competing Interests: Disclosures Dr Till Althoff has received research grants for investigator-initiated trials from Biosense Webster and honoraria as consultant from Corify Care. Prof Lluís Mont has received honoraria as a lecturer and consultant and has received research grants from Abbott Medical, Biosense Webster, Boston Scientific, and Medtronic; he is a shareholder of Galgo Medical SL and Corify Care. Drs Andreu Climent and María S. Guillem are co-founders of Corify Care and receive honoraria from the company. Dr Ismael Hernández is co-founder of Corify Care. Jana Reventos is employed by Corify Care. Drs Ivo Roca-Luque, Jose M. Tolosana, and Andreu Porta-Sanchez received honoraria as consultants for Biosense Webster, Boston Scientific, and Medtronic. Dr Jean-Baptiste Guichard reports honoraria as a consultant from Microport CRM and as lecturer from Microport CRM and Abbott and an unrestricted grant support for a fellowship from Abbott Laboratories., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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45. Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review.

Author: Mascia G, Brugada J, Barca L, Benenati S, Della Bona R, Scarà A, Russo V, Arbelo E, Di Donna P, and Porto I
Subjects: Humans, Prognosis, Electrophysiologic Techniques, Cardiac, Risk Assessment, Electrocardiography, Risk Factors, Male, Female, Action Potentials drug effects, Predictive Value of Tests, Middle Aged, Brugada Syndrome physiopathology, Brugada Syndrome diagnosis, Brugada Syndrome chemically induced
Abstract: Background: Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations., Methods: A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group., Results: Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status., Conclusion: In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification., (Copyright © 2024 Italian Federation of Cardiology - I.F.C. All rights reserved.)
Published: 2024
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46. A narrative review of inherited arrhythmogenic syndromes in young population: role of genetic diagnosis in exercise recommendations.

Author: Sarquella-Brugada G, Martínez-Barrios E, Cesar S, Toro R, Cruzalegui J, Greco A, Díez-Escuté N, Cerralbo P, Chipa F, Arbelo E, Diez-López C, Grazioli G, Balderrábano N, and Campuzano O
Abstract: Sudden cardiac death is a rare but socially devastating event, especially if occurs in young people. Usually, this unexpected lethal event occurs during or just after exercise. One of the leading causes of sudden cardiac death is inherited arrhythmogenic syndromes, a group of genetic entities characterised by incomplete penetrance and variable expressivity. Exercise can be the trigger for malignant arrhythmias and even syncope in population with a genetic predisposition, being sudden cardiac death as the first symptom. Due to genetic origin, family members must be clinically assessed and genetically analysed after diagnosis or suspected diagnosis of a cardiac channelopathy. Early identification and adoption of personalised preventive measures is crucial to reduce risk of arrhythmias and avoid new lethal episodes. Despite exercise being recommended by the global population due to its beneficial effects on health, particular recommendations for these patients should be adopted considering the sport practised, level of demand, age, gender, arrhythmogenic syndrome diagnosed but also genetic diagnosis. Our review focuses on the role of genetic background in sudden cardiac death during exercise in child and young population., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2024
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47. Disease phenotypes in adult patients with suspected undifferentiated autoinflammatory diseases and PFAPA syndrome: Clinical and therapeutic implications.

Author: Gómez-Caverzaschi V, Yagüe J, Espinosa G, Mayordomo-Bofill I, Bedón-Galarza R, Araújo O, Pelegrín L, Arbelo E, Morales X, Balagué O, Figueras-Nart I, Mascaró JM, Fuertes I, Giavedoni P, Muxí A, Alobid I, Vilaseca I, Cervera R, Aróstegui JI, Mensa-Vilaró A, and Hernández-Rodríguez J
Subjects: Humans, Adult, Female, Male, Retrospective Studies, Fever drug therapy, Fever diagnosis, Young Adult, Middle Aged, Colchicine therapeutic use, Syndrome, Adolescent, Phenotype, Stomatitis, Aphthous diagnosis, Stomatitis, Aphthous drug therapy, Pharyngitis drug therapy, Pharyngitis diagnosis, Lymphadenitis diagnosis, Lymphadenitis drug therapy, Hereditary Autoinflammatory Diseases diagnosis, Hereditary Autoinflammatory Diseases drug therapy, Hereditary Autoinflammatory Diseases genetics
Abstract: Background: Undifferentiated autoinflammatory diseases are characterized by recurrent or persistent fever, usually combined with other inflammatory manifestations, and negative or inconclusive genetic studies for monogenic autoinflammatory disorders., Aims: To define and characterize disease phenotypes in adult patients diagnosed in an adult reference center with undifferentiated autoinflammatory diseases, and to analyze the efficacy of the drugs used in order to provide practical diagnostic and therapeutic recommendations., Methods: Retrospective study (2015-2022) of patients with undifferentiated autoinflammatory diseases among all patients visited in our reference center. Demographic, clinical, laboratory features and detailed therapeutic information was collected., Results: Of the 334 patients with a suspected autoinflammatory disease, 134 (40%) patients (61% women) were initially diagnosed with undifferentiated autoinflammatory diseases. Mean age at disease onset and at diagnosis was 28.7 and 37.7 years, respectively. In 90 (67.2%) patients, symptoms started during adulthood. Forty-four (32.8%) patients met diagnostic/classification criteria for adult periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. In the remaining patients, four additional phenotypes were differentiated according to the predominant manifestations: a) Predominantly fever phenotype (n = 18; 13.4%); b) Predominantly abdominal/pleuritic pain phenotype (n = 9; 6.7%); c) Predominantly pericarditis phenotype (n = 18; 13.4%), and d) Complex syndrome phenotype (n = 45; 33.6%). Prednisone (mainly on demand), colchicine and anakinra were the drugs commonly used. Overall, complete responses were achieved with prednisone in 41.3%, colchicine in 40.2%, and anakinra in 58.3% of patients in whom they were used. By phenotypes, prednisone on demand was more effective in adult PFAPA syndrome and colchicine in patients with the abdominal/pleuritic pain pattern and PFAPA syndrome. Patients with complex syndrome achieved complete responses with prednisone (21.9%), colchicine (25.7%) and anakinra (44.4%), and were the group more often requiring additional immunosuppressive drugs., Conclusions: The analysis of the largest single-center series of adult patients with undifferentiated autoinflammatory diseases identified and characterized different disease phenotypes and their therapeutic approaches. This study is expected to contribute to increase the awareness of physicians for an early identification of these conditions, and to provide the best known therapeutic options., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: José Hernández-Rodríguez reports financial support was provided by Hospital Clínic de Barcelona. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2024
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48. Predictors of failed left bundle branch pacing implant in heart failure with reduced ejection fraction: Importance of left ventricular diameter and QRS morphology.

Author: Graterol FR, Pujol-López M, Borràs R, Ayala B, Uribe L, Guasch E, Regany-Closa M, Niebla M, Carro E, Guichard JB, Castel MÁ, Arbelo E, Porta-Sánchez A, Sitges M, Brugada J, Roca-Luque I, Doltra A, Mont L, and Tolosana JM
Abstract: Background: Left bundle branch pacing (LBBP) is considered an alternative to cardiac resynchronization therapy (CRT). However, LBBP is not suitable for all patients with heart failure., Objective: The aim of our study was to identify predictors of unsuccessful LBBP implantation in CRT candidates., Methods: A cohort of consecutive patients with indications for CRT were included. Clinical, echocardiographic, and electrocardiographic variables were prospectively recorded., Results: A total of 187 patients were included in the analysis. LBBP implantation was successful in 152 of 187 patients (81.2%) and failed in 35 of 187 patients (18.7%). The causes of unsuccessful implantation were unsatisfactory paced QRS morphology (28 of 35 [80%]), inability to screw the helix (4 of 35 [11.4%]), lead instability (2 of 35 [5.7%]), and high pacing thresholds (1 of 35 [2.8%]). The left ventricular end-diastolic diameter (LVEDD), non-LBBB (left bundle branch block) QRS morphology, and QRS width were predictors of failed implantation according to the univariate analysis. According to the multivariate regression analysis, LVEDD (odds ratio 1.31 per 5-mm increase; 95% confidence interval 1.05-1.63 per 5-mm increase; P = .02) and non-LBBB (odds ratio 3.07; 95% confidence interval 1.08-8.72; P = .03) were found to be independent predictors of unsuccessful LBBP implantation. An LVEDD of 60 mm has 60% sensitivity and 71% specificity for predicting LBBP implant failure., Conclusion: When LBBP was used as CRT, LVEDD and non-LBBB QRS morphology predicted unsuccessful implantation. Non-LBBB triples the likelihood of failed implantation independent of LVEDD. Caution should be taken when considering these parameters to plan the best pacing strategy for patients., Competing Interests: Disclosures Dr Pujol-López has received speaker honoraria from Medtronic. Dr Tolosana has received honoraria as a lecturer and consultant from Abbott, Boston Scientific, and Medtronic. Dr Mont has received unrestricted research grants, fellowship program support, and honoraria as a lecturer and consultant from Abbott, Biotronik, Boston Scientific, LivaNova, and Medtronic; he holds stock in Galgo Medical and Corify. Dr Roca-Luque has received honoraria as a lecturer and consultant from Abbott and Biosense Webster. Dr Sitges has received consultant fees and speaker honoraria from Abbott, Medtronic, General Electric, and Edwards Lifesciences. Dr Castel has received speaker honoraria from Boston Scientific, Abbott, and MicroPort. Dr Arbelo has received speaker honoraria from Biosense Webster and Bayer. Dr Porta-Sánchez has received honoraria as a lecturer and consultant from Biosense Webster, Abbott, and Boston Scientific. Dr Guichard has received honoraria as a consultant from MicroPort CRM, honoraria as a lecturer from MicroPort CRM and Abbott, and unrestricted grant support for a fellowship from Abbott. The remaining authors declare that they have no conflicts of interest., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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49. Implantable loop recorders in patients with Brugada syndrome: the BruLoop study.

Author: Bergonti M, Sacher F, Arbelo E, Crotti L, Sabbag A, Casella M, Saenen J, Rossi A, Monaco C, Pannone L, Compagnucci P, Russo V, Heller E, Santoro A, Berne P, Bisignani A, Baldi E, Van Leuven O, Migliore F, Marcon L, Dagradi F, Sfondrini I, Landra F, Comune A, Cespón-Fernández M, Nesti M, Santoro F, Magnocavallo M, Vicentini A, Conti S, Ribatti V, Brugada P, de Asmundis C, Brugada J, Tondo C, Schwartz PJ, Haissaguerre M, Auricchio A, and Conte G
Subjects: Female, Humans, Male, Middle Aged, Arrhythmias, Cardiac complications, Arrhythmias, Cardiac diagnosis, Electrocardiography methods, Electrocardiography, Ambulatory methods, Adult, Brugada Syndrome complications, Brugada Syndrome diagnosis, Brugada Syndrome therapy, Defibrillators, Implantable, Pacemaker, Artificial
Abstract: Background and Aims: Available data on continuous rhythm monitoring by implantable loop recorders (ILRs) in patients with Brugada syndrome (BrS) are scarce. The aim of this multi-centre study was to evaluate the diagnostic yield and clinical implication of a continuous rhythm monitoring strategy by ILRs in a large cohort of BrS patients and to assess the precise arrhythmic cause of syncopal episodes., Methods: A total of 370 patients with BrS and ILRs (mean age 43.5 ± 15.9, 33.8% female, 74.1% symptomatic) from 18 international centers were included. Patients were followed with continuous rhythm monitoring for a median follow-up of 3 years., Results: During follow-up, an arrhythmic event was recorded in 30.7% of symptomatic patients [18.6% atrial arrhythmias (AAs), 10.2% bradyarrhythmias (BAs), and 7.3% ventricular arrhythmias (VAs)]. In patients with recurrent syncope, the aetiology was arrhythmic in 22.4% (59.3% BAs, 25.0% VAs, and 15.6% AAs). The ILR led to drug therapy initiation in 11.4%, ablation procedure in 10.9%, implantation of a pacemaker in 2.5%, and a cardioverter-defibrillator in 8%. At multivariate analysis, the presence of symptoms [hazard ratio (HR) 2.5, P = .001] and age >50 years (HR 1.7, P = .016) were independent predictors of arrhythmic events, while inducibility of ventricular fibrillation at the electrophysiological study (HR 9.0, P < .001) was a predictor of VAs., Conclusions: ILR detects arrhythmic events in nearly 30% of symptomatic BrS patients, leading to appropriate therapy in 70% of them. The most commonly detected arrhythmias are AAs and BAs, while VAs are detected only in 7% of cases. Symptom status can be used to guide ILR implantation., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Published: 2024
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50. The 2023 ESC guidelines for the management of cardiomyopathies: the 10 commandments.

Author: Kaski JP and Arbelo E
Subjects: Humans, Practice Guidelines as Topic, Cardiomyopathies diagnosis, Cardiomyopathies therapy
Published: 2024
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