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1. The unexpected surface of asteroid (101955) Bennu

Author

D. S. Lauretta, D. N. DellaGiustina, C. A. Bennett, D. R. Golish, K. J. Becker, S. S. Balram-Knutson, O. S. Barnouin, T. L. Becker, W. F. Bottke, W. V. Boynton, H. Campins, H. C. Connolly Jr, C. Y. Drouet d’Aubigny, J. P. Dworkin, J. P. Emery, H. L. Enos, V. E. Hamilton, C. W. Hergenrother, E. S. Howell, M. R. M. Izawa, H. H. Kaplan, M. C. Nolan, B. Rizk, H. L. Roper, D. J. Scheeres, P. H. Smith, K. J. Walsh, C. W. V. Wolner, D. E. Highsmith, J. Small, D. Vokrouhlický, N. E. Bowles, E. Brown, K. L. Donaldson Hanna, T. Warren, C. Brunet, R. A. Chicoine, S. Desjardins, D. Gaudreau, T. Haltigin, S. Millington-Veloza, A. Rubi, J. Aponte, N. Gorius, A. Lunsford, B. Allen, J. Grindlay, D. Guevel, D. Hoak, J. Hong, D. L. Schrader, J. Bayron, O. Golubov, P. Sánchez, J. Stromberg, M. Hirabayashi, C. M. Hartzell, S. Oliver, M. Rascon, A. Harch, J. Joseph, S. Squyres, D. Richardson, L. McGraw, R. Ghent, R. P. Binzel, M. M. Al Asad, C. L. Johnson, L. Philpott, H. C. M. Susorney, E. A. Cloutis, R. D. Hanna, F. Ciceri, A. R. Hildebrand, E.-M. Ibrahim, L. Breitenfeld, T. Glotch, A. D. Rogers, B. E. Clark, S. Ferrone, C. A. Thomas, Y. Fernandez, W. Chang, A. Cheuvront, D. Trang, S. Tachibana, H. Yurimoto, J. R. Brucato, G. Poggiali, M. Pajola, E. Dotto, E. Mazzotta Epifani, M. K. Crombie, C. Lantz, J. de Leon, J. Licandro, J. L. Rizos Garcia, S. Clemett, K. Thomas-Keprta, S. Van wal, M. Yoshikawa, J. Bellerose, S. Bhaskaran, C. Boyles, S. R. Chesley, C. M. Elder, D. Farnocchia, A. Harbison, B. Kennedy, A. Knight, N. Martinez-Vlasoff, N. Mastrodemos, T. McElrath, W. Owen, R. Park, B. Rush, L. Swanson, Y. Takahashi, D. Velez, K. Yetter, C. Thayer, C. Adam, P. Antreasian, J. Bauman, C. Bryan, B. Carcich, M. Corvin, J. Geeraert, J. Hoffman, J. M. Leonard, E. Lessac-Chenen, A. Levine, J. McAdams, L. McCarthy, D. Nelson, B. Page, J. Pelgrift, E. Sahr, K. Stakkestad, D. Stanbridge, D. Wibben, B. Williams, K. Williams, P. Wolff, P. Hayne, D. Kubitschek, M. A. Barucci, J. D. P. Deshapriya, S. Fornasier, M. Fulchignoni, P. Hasselmann, F. Merlin, A. Praet, E. B. Bierhaus, O. Billett, A. Boggs, B. Buck, S. Carlson-Kelly, J.Cerna, K. Chaffin, E. Church, M. Coltrin, J. Daly, A. Deguzman, R. Dubisher, D. Eckart, D. Ellis, P. Falkenstern, A. Fisher, M. E. Fisher, P. Fleming, K. Fortney, S. Francis, S. Freund, S. Gonzales, P. Haas, A. Hasten, D. Hauf, A. Hilbert, D. Howell, F. Jaen, N. Jayakody, M. Jenkins, K. Johnson, M. Lefevre, H. Ma, C. Mario, K. Martin, C. May, M. McGee, B. Miller, C. Miller, G. Miller, A. Mirfakhrai, E. Muhle, C. Norman, R. Olds, C. Parish, M. Ryle, M. Schmitzer, P. Sherman, M. Skeen, M. Susak, B. Sutter, Q. Tran, C. Welch, R. Witherspoon, J. Wood, J. Zareski, M. Arvizu-Jakubicki, E. Asphaug, E. Audi, R.-L. Ballouz, R. Bandrowski, S. Bendall, H. Bloomenthal, D. Blum, J. Brodbeck, K. N. Burke, M. Chojnacki, A. Colpo, J. Contreras, J. Cutts, D. Dean, B. Diallo, D. Drinnon, K. Drozd, R. Enos, C. Fellows, T. Ferro, M. R. Fisher, G. Fitzgibbon, M. Fitzgibbon, J. Forelli, T. Forrester, I. Galinsky, R. Garcia, A. Gardner, N. Habib, D. Hamara, D. Hammond, K. Hanley, K. Harshman, K. Herzog, D. Hill, C. Hoekenga, S. Hooven, E. Huettner, A. Janakus, J. Jones, T. R. Kareta, J. Kidd, K. Kingsbury, L. Koelbel, J. Kreiner, D. Lambert, C. Lewin, B. Lovelace, M. Loveridge, M. Lujan, C. K. Maleszewski, R. Malhotra, K. Marchese, E. McDonough, N. Mogk, V. Morrison, E. Morton, R. Munoz, J. Nelson, J. Padilla, R. Pennington, A. Polit, N. Ramos, V. Reddy, M. Riehl, S. Salazar, S. R. Schwartz, S. Selznick, N. Shultz, S. Stewart, S. Sutton, T. Swindle, Y. H. Tang, M. Westermann, D. Worden, T. Zega, Z. Zeszut, A. Bjurstrom, L. Bloomquist, C. Dickinson, E. Keates, J. Liang, V. Nifo, A. Taylor, F. Teti, M. Caplinger, H. Bowles, S. Carter, S. Dickenshied, D. Doerres, T. Fisher, W. Hagee, J. Hill, M. Miner, D. Noss, N. Piacentine, M. Smith, A. Toland, P. Wren, M. Bernacki, D. Pino Munoz, S.-i. Watanabe, S. A. Sandford, A. Aqueche, B. Ashman, M. Barker, A. Bartels, K. Berry, B. Bos, R. Burns, A. Calloway, R. Carpenter, N. Castro, R. Cosentino, J. Donaldson, J. Elsila Cook, C. Emr, D. Everett, D. Fennell, K. Fleshman, D. Folta, D. Gallagher, J. Garvin, K. Getzandanner, D. Glavin, S. Hull, K. Hyde, H. Ido, A. Ingegneri, N. Jones, P. Kaotira, L. F. Lim, A. Liounis, C. Lorentson, D. Lorenz, J. Lyzhoft, E. M. Mazarico, R. Mink, W. Moore, M. Moreau, S. Mullen, J. Nagy, G. Neumann, J. Nuth, D. Poland, D. C. Reuter, L. Rhoads, S. Rieger, D. Rowlands, D. Sallitt, A. Scroggins, G. Shaw, A. A. Simon, J. Swenson, P. Vasudeva, M. Wasser, R. Zellar, J. Grossman, G. Johnston, M. Morris, J. Wendel, A. Burton, L. P. Keller, L. Mcnamara, S. Messenger, K. Messenger, A. Nguyen, K. Righter, E. Queen, K. Bellamy, K. Dill, S. Gardner, M. Giuntini, B. Key, J. Kissell, D. Patterson, D. Vaughan, B. Wright, R. W. Gaskell, L. Le Corre, J.-Y. Li, J. L. Molaro, E. E. Palmer, M. A. Siegler, P. Tricarico, J. R. Weirich, X.-D. Zou, T. Ireland, K. Tait, P. Bland, S. Anwar, N. Bojorquez-Murphy, P. R. Christensen, C. W. Haberle, G. Mehall, K. Rios, I. Franchi, B. Rozitis, C. B. Beddingfield, J. Marshall, D. N. Brack, A. S. French, J. W. McMahon, E. R. Jawin, T. J. McCoy, S. Russell, M. Killgore, J. L. Bandfield, B. C. Clark, M. Chodas, M. Lambert, R. A. Masterson, M. G. Daly, J. Freemantle, J. A. Seabrook, K. Craft, R. T. Daly, C. Ernst, R. C. Espiritu, M. Holdridge, M. Jones, A. H. Nair, L. Nguyen, J. Peachey, M. E. Perry, J. Plescia, J. H. Roberts, R. Steele, R. Turner, J. Backer, K. Edmundson, J. Mapel, M. Milazzo, S. Sides, C. Manzoni, B. May, M. Delbo, G. Libourel, P. Michel, A. Ryan, F. Thuillet, and B. Marty

Subjects
Astronomy, Exobiology
Abstract

NASA’S Origins, Spectral Interpretation, Resource Identification and Security-Regolith Explorer (OSIRIS-REx) spacecraft recently arrived at the near-Earth asteroid (101955) Bennu, a primitive body that represents the objects that may have brought prebiotic molecules and volatiles such as water to Earth1. Bennu is a low-albedo B-type asteroid2 that has been linked to organic-rich hydrated carbonaceous chondrites3. Such meteorites are altered by ejection from their parent body and contaminated by atmospheric entry and terrestrial microbes. Therefore, the primary mission objective is to return a sample of Bennu to Earth that is pristine—that is, not affected by these processes4. The OSIRIS-REx spacecraft carries a sophisticated suite of instruments to characterize Bennu’s global properties, support the selection of a sampling site and document that site at a sub-centimetre scale5,6,7,8,9,10,11. Here we consider early OSIRIS-REx observations of Bennu to understand how the asteroid’s properties compare to pre-encounter expectations and to assess the prospects for sample return. The bulk composition of Bennu appears to be hydrated and volatile-rich, as expected. However, in contrast to pre-encounter modelling of Bennu’s thermal inertia12 and radar polarization ratios13—which indicated a generally smooth surface covered by centimetre-scale particles—resolved imaging reveals an unexpected surficial diversity. The albedo, texture, particle size and roughness are beyond the spacecraft design specifications. On the basis of our pre-encounter knowledge, we developed a sampling strategy to target 50-metre-diameter patches of loose regolith with grain sizes smaller than two centimetres4. We observe only a small number of apparently hazard-free regions, of the order of 5 to 20 metres in extent, the sampling of which poses a substantial challenge to mission success.

Published
2019
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2. The operational environment and rotational acceleration of asteroid (101955) Bennu from OSIRIS-REx observations

Author

C. W. Hergenrother, C. K. Maleszewski, M. C. Nolan, J.-Y. Li, C. Y. Drouet d’Aubigny, F. C. Shelly, E. S. Howell, T. R. Kareta, M. R. M. Izawa, M. A. Barucci, E. B. Bierhaus, S. R. Chesley, B. E. Clark, E. J. Christensen, D. N. DellaGiustina, S. Fornasier, D. R. Golish, C. M. Hartzell, B. Rizk, D. J. Scheeres, P. H. Smith, X.-D. Zou, D. S. Lauretta, Jason Peter Dworkin, D.E. Highsmith, J. Small, D. Vokrouhlický, N.E. Bowles, E. Brown, K.L. Donaldson Hanna, T. Warren, C. Brunet, R.A. Chicoine, S. Desjardins, D. Gaudreau, T. Haltigin, S. Millington-Veloza, A. Rubi, J. Aponte, N. Gorius, A. Lunsford, B. Allen, J. Grindlay, D. Guevel, D. Hoak, J. Hong, D.L. Schrader, J. Bayron, O. Golubov, P. Sánchez, J. Stromberg, M. Hirabayashi, C.M. Hartzell, S. Oliver, M. Rascon, A. Harch, J. Joseph, S. Squyres, D. Richardson, J.P. Emery, L. McGraw, R. Ghent, R.P. Binzel, M.M. Al Asad, C.L. Johnson, L. Philpott, H.C.M. Susorney, E.A. Cloutis, R.D. Hanna, H.C. Connolly Jr, F. Ciceri, A.R. Hildebrand, E.-M. Ibrahim, L. Breitenfeld, T. Glotch, A.D. Rogers, B.E. Clark, S. Ferrone, C.A. Thomas, H. Campins, Y. Fernandez, W. Chang, A. Cheuvront, D. Trang, S. Tachibana, H. Yurimoto, J.R. Brucato, G. Poggiali, M. Pajola, E. Dotto, E. Mazzotta Epifani, M.K. Crombie, C. Lantz, M.R.M. Izawa, J. de Leon, J. Licandro, J.L.Rizos Garcia, S. Clemett, K. Thomas-Keprta, S. Van wal, M. Yoshikawa, J. Bellerose, S. Bhaskaran, C. Boyles, S.R. Chesley, C.M. Elder, D. Farnocchia, A. Harbison, B. Kennedy, A. Knight, N. Martinez-Vlasoff, N. Mastrodemos, T. McElrath, W. Owen, R. Park, B. Rush, L. Swanson, Y. Takahashi, D. Velez, K. Yetter, C. Thayer, C. Adam, P. Antreasian, J. Bauman, C. Bryan, B. Carcich, M. Corvin, J. Geeraert, J. Hoffman, J.M. Leonard, E. Lessac-Chenen, A. Levine, J. McAdams, L. McCarthy, D. Nelson, B. Page, J. Pelgrift, E. Sahr, K. Stakkestad, D. Stanbridge, D. Wibben, B. Williams, K. Williams, P. Wolff, P. Hayne, D. Kubitschek, M.A. Barucci, J.D.P. Deshapriya, M. Fulchignoni, P. Hasselmann, F. Merlin, A. Praet, E.B. Bierhaus, O. Billett, A. Boggs, B. Buck, S. Carlson-Kelly, J. Cerna, K. Chaffin, E. Church, M. Coltrin, J. Daly, A. Deguzman, R. Dubisher, D. Eckart, D. Ellis, P. Falkenstern, A. Fisher, M.E. Fisher, P. Fleming, K. Fortney, S. Francis, S. Freund, S. Gonzales, P. Haas, A. Hasten, D. Hauf, A. Hilbert, D. Howell, F. Jaen, N. Jayakody, M. Jenkins, K. Johnson, M. Lefevre, H. Ma, C. Mario, K. Martin, C. May, M. McGee, B. Miller, C. Miller, G. Miller, A. Mirfakhrai, E. Muhle, C. Norman, R. Olds, C. Parish, M. Ryle, M. Schmitzer, P. Sherman, M. Skeen, M. Susak, B. Sutter, Q. Tran, C. Welch, R. Witherspoon, J. Wood, J. Zareski, M. Arvizu-Jakubicki, E. Asphaug, E. Audi, R.-L. Ballouz, R. Bandrowski, K.J. Becker, T.L. Becker, S. Bendall, C.A. Bennett, H. Bloomenthal, D. Blum, W.V. Boynton, J. Brodbeck, K.N. Burke, M. Chojnacki, A. Colpo, J. Contreras, J. Cutts, C. Y. Drouet d'Aubigny, D. Dean, D.N. DellaGiustina, B. Diallo, D. Drinnon, K. Drozd, H.L. Enos, R. Enos, C. Fellows, T. Ferro, M.R. Fisher, G. Fitzgibbon, M. Fitzgibbon, J. Forelli, T. Forrester, I. Galinsky, R. Garcia, A. Gardner, D.R. Golish, N. Habib, D. Hamara, D. Hammond, K. Hanley, K. Harshman, C.W. Hergenrother, K. Herzog, D. Hill, C. Hoekenga, S. Hooven, E.S. Howell, E. Huettner, A. Janakus, J. Jones, T.R. Kareta, J. Kidd, K. Kingsbury, S.S. Balram-Knutson, L. Koelbel, J. Kreiner, D. Lambert, D.S. Lauretta, C. Lewin, B. Lovelace, M. Loveridge, M. Lujan, C.K. Maleszewski, R. Malhotra, K. Marchese, E. McDonough, N. Mogk, V. Morrison, E. Morton, R. Munoz, J. Nelson, M.C. Nolan, J. Padilla, R. Pennington, A. Polit, N. Ramos, V. Reddy, M. Riehl, Y.H. Tang, M. Westermann, C.W.V. Wolner, D. Worden, T. Zega, Z. Zeszut, A. Bjurstrom, L. Bloomquist, C. Dickinson, E. Keates, J. Liang, V. Nifo, A. Taylor, F. Teti, M. Caplinger, H. Bowles, S. Carter, S. Dickenshied, D. Doerres, T. Fisher, W. Hagee, J. Hill, M. Miner, D. Noss, N. Piacentine, M. Smith, A. Toland, P. Wren, M. Bernacki, D. Pino Munoz, S.-i. Watanabe, S. A. Sandford, A. Aqueche, B. Ashman, M. Barker, A. Bartels, K. Berry, B. Bos, R. Burns, A. Calloway, R. Carpenter, N. Castro, R. Cosentino, J. Donaldson, J.P. Dworkin, J. Elsila Cook, C. Emr, D. Everett, D. Fennell, K. Fleshman, D. Folta, D. Gallagher, J. Garvin, K. Getzandanner, D. Glavin, S. Hull, K. Hyde, H. Ido, A. Ingegneri, N. Jones, P. Kaotira, L.F. Lim, A. Liounis, C. Lorentson, D. Lorenz, J. Lyzhoft, E.M. Mazarico, R. Mink, W. Moore, M. Moreau, S. Mullen, J. Nagy, G. Neumann, J. Nuth, D. Poland, D.C. Reuter, L. Rhoads, S. Rieger, D. Rowlands, D. Sallitt, A. Scroggins, G. Shaw, A.A. Simon, J. Swenson, P. Vasudeva, M. Wasser, R. Zellar, J. Grossman, G. Johnston, M. Morris, J. Wendel, A. Burton, L.P. Keller, L. McNamara, S. Messenger, K. Nakamura-Messenger, A. Nguyen, K. Righter, E. Queen, K. Bellamy, K. Dill, S. Gardner, M. Giuntini, B. Key, J. Kissell, D. Patterson, D. Vaughan, B. Wright, R.W. Gaskell, L. Le Corre, J.L. Molaro, E.E. Palmer, M.A. Siegler, P. Tricarico, J.R. Weirich, T. Ireland, K. Tait, P. Bland, S. Anwar, A.S. French, J.W. McMahon, D.J. Scheeres, E.R. Jawin, T.J. McCoy, S. Russell, M. Killgore, W.F. Bottke, V.E. Hamilton, H.H. Kaplan, K.J. Walsh, J.L. Bandfield, B.C. Clark, M. Chodas, M. Lambert, R.A. Masterson, M.G. Daly, J. Freemantle, J.A. Seabrook, O.S. Barnouin, K. Craft, R.T. Daly, C. Ernst, R.C. Espiritu, M. Holdridge, M. Jones, A.H. Nair, L. Nguyen, J. Peachey, M.E. Perry, J. Plescia, J.H. Roberts, R. Steele, R. Turner, J. Backer, K. Edmundson, J. Mapel, M. Milazzo, S. Sides, C. Manzoni, B. May, M. Delbo’, G. Libourel, P. Michel, A. Ryan, F. Thuillet, and B. Marty

Subjects
Geosciences (General)
Abstract

During its approach to asteroid (101955) Bennu, NASA’s Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft surveyed Bennu’s immediate environment, photometric properties, and rotation state. Discovery of a dusty environment, a natural satellite, or unexpected asteroid characteristics would have had consequences for the mission’s safety and observation strategy. Here we show that spacecraft observations during this period were highly sensitive to satellites (sub-meter scale) but reveal none, although later navigational images indicate that further investigation is needed. We constrain average dust production in September 2018 from Bennu’s surface to an upper limit of 150 g/s averaged over 34 min. Bennu’s disk-integrated photometric phase function validates measurements from the pre-encounter astronomical campaign. We demonstrate that Bennu’s rotation rate is accelerating continuously at 3.63 ± 0.52 × 10^(–6) degrees/sq. day, likely due to the Yarkovsky–O’Keefe–Radzievskii–Paddack (YORP) effect, with evolutionary implications.

Published
2019
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3. Author Correction: Shape of (101955) Bennu indicative of a rubble pile with internal stiffness

Author

M. Lefevre, Aaron S. Burton, Carina Bennett, J. A. Mapel, Renu Malhotra, Peter Fleming, J. McAdams, N. Mogk, R. L. Ballouz, P. H. Smith, V. Nifo, C. K. Maleszewski, Timothy D. Swindle, E. Dotto, Stephen R. Schwartz, C. May, J. Bayron, D. Patterson, D. Guevel, Ellen S. Howell, Humberto Campins, J. Kissell, E. Brown, J. Wood, E. Muhle, John Robert Brucato, J. Small, B. Miller, Oleksiy Golubov, R. Pennington, K. Harshman, J. Nelson, Catherine Elder, M. McGee, R. Burns, J. Contreras, S. Hull, D. Kubitschek, D. Noss, Andrew J. Liounis, J. Backer, B. May, G. Fitzgibbon, J. Donaldson, D. Worden, Bashar Rizk, R. Witherspoon, Catherine L. Johnson, Erica Jawin, G. Shaw, A. Aqueche, Dolores H. Hill, D. Folta, S. Ferrone, M. Lujan, Giovanni Poggiali, B. G. Williams, S. Selznick, Melissa A. Morris, K. Rios, Sara S. Russell, D. Lambert, J. Hong, Jeffrey B. Plescia, H. Bloomenthal, D. Drinnon, Olivier S. Barnouin, Derek S. Nelson, Amanda E. Toland, Michael C. Moreau, J. A. Seabrook, K. Dill, A. Mirfakhrai, K. Hyde, J. D. P. Deshapriya, Hannah Kaplan, Timothy P. McElrath, Juliette I. Brodbeck, N. Ramos, S. Stewart, James B. Garvin, Sei-ichiro Watanabe, M. Arvizu-Jakubicki, Jason P. Dworkin, Matthew A. Siegler, Collin Lewin, Masatoshi Hirabayashi, L. Bloomquist, S. Gardner, Keiko Nakamura-Messenger, A. H. Nair, M. Schmitzer, P. Haas, Julie Bellerose, Dolan E. Highsmith, L. Koelbel, C. C. Lorentson, J. Zareski, E. Queen, S. R. Chesley, Philip A. Bland, A. Cheuvront, V. E. Hamilton, Ronald G. Mink, N. Mastrodemos, H. C. Connolly, K. Bellamy, M. Killgore, A. Gardner, Y. Takahashi, M. Lambert, R. C. Espiritu, Z. Zeszut, E. T. Morton, Kevin J. Walsh, Timothy D. Glotch, M. Skeen, Brian Kennedy, Matthew R.M. Izawa, G. Neumann, F. Teti, D. Doerres, A. Hasten, F. Ciceri, D. Howell, A. Deguzman, J. Nagy, D. Vaughan, H. Ma, C. Lantz, D. N. Brack, David K. Hammond, Erwan Mazarico, Leilah K. McCarthy, L. Rhoads, Kathleen L. Craft, C. Welch, Jay W. McMahon, C. L. Parish, D. C. Reuter, M. Giuntini, N. Castro, Clive Dickinson, J. Kreiner, K. Kingsbury, S. Dickenshied, Joseph A. Nuth, Alan R. Hildebrand, Erik Asphaug, H. Ido, Eric M. Sahr, A. Harbison, Arlin E. Bartels, T. Forrester, D. Eckart, R. Bandrowski, Michael K. Barker, Robert Gaskell, J. Wendel, S. Freund, Marc Bernacki, Ryan S. Park, A. Taylor, E. B. Bierhaus, S. Millington-Veloza, J. Stromberg, L. B. Breitenfeld, K. Stakkestad, D. Ellis, Timothy J. McCoy, M. Susak, Richard G. Cosentino, C. Manzoni, Hisayoshi Yurimoto, C. Drouet d'Aubigny, A. Bjurstrom, Masako Yoshikawa, S. Francis, J. Peachey, J. Geeraert, K. Marchese, O. Billett, M. Rascon, F. Jaen, B. Diallo, Martin Miner, Kris J. Becker, E. Mazzotta Epifani, Florian Thuillet, A. Knight, James H. Roberts, Pasquale Tricarico, Edward A. Cloutis, T. Fisher, Dale Stanbridge, A. Colpo, Osiris-Rex Team, S. Gonzales, Q. Tran, M. K. Crombie, John Marshall, N. Bojorquez-Murphy, David Vokrouhlický, Allen W. Lunsford, H. Bowles, K. L. Edmundson, R. A. Masterson, Peter G. Antreasian, N. Gorius, Benjamin Rozitis, D. Pino Muñoz, S. Carlson-Kelly, C. Thayer, J. Elsila Cook, B. C. Clark, N. Piacentine, José C. Aponte, M. Al Asad, M. A. Barucci, D. Blum, P. Falkenstern, Neil Bowles, Matthew Chojnacki, J. M. Leonard, J. Daly, K. Yetter, M. R. Fisher, Jeffrey N. Grossman, A. Boggs, N. Jayakody, Cristina A. Thomas, C.M. Ernst, Namrah Habib, J. N. Kidd, R. J. Steele, Andrew B. Calloway, Andrew Ryan, Kimberly T. Tait, Paul O. Hayne, J. Y. Li, K. L. Berry, William V. Boynton, Yanga R. Fernandez, D. A. Lorenz, M. Wasser, Daniel J. Scheeres, K. Fortney, A. Scroggins, B. Allen, B. Sutter, T. Ferro, Jonathan Joseph, Derek C. Richardson, D. Hoak, Brian Carcich, W. Chang, P. Wren, C. Boyles, Kaj E. Williams, B. Marty, J. Liang, J. Hoffman, A. Harch, Daniel R. Wibben, Jamie Molaro, S. Rieger, R. Enos, C. W. Hergenrother, Stephen R. Sutton, J. Grindlay, E. J. Lessac-Chenen, E. Huettner, C. Norman, P. Sherman, L. Swanson, M. Coltrin, S. Van wal, B. Buck, A. Fisher, Kevin Righter, Brian Rush, David D. Rowlands, Lauren McGraw, A. Levine, K. Drozd, D. Gaudreau, A. Nguyen, S. Sides, M. Chodas, R. Dubisher, B. Ashman, Michael Caplinger, Amy Simon, W. Moore, S. S. Balram-Knutson, R. Carpenter, S. Fornasier, Shogo Tachibana, Russell Turner, Ian A. Franchi, Trevor Ireland, Chloe B. Beddingfield, D. F. Everett, M. Corvin, Lindsay P. Keller, Tammy L. Becker, S. Carter, J. L. Rizos Garcia, Mark E. Perry, E. Keates, Michael C. Nolan, P. Vasudeva, C. Fellows, K. Herzog, Mark A. Jenkins, J. R. Weirich, J. Swenson, D. R. Golish, Davide Farnocchia, Lydia C. Philpott, Rebecca R. Ghent, Hannah C.M. Susorney, S. W. Squyres, Pedro Hasselmann, J. Hill, Thomas J. Zega, B. Key, Marco Delbo, A. S. French, P. Sánchez, A. Hilbert, J. Y. Pelgrift, R. P. Binzel, L. McNamara, Vishnu Reddy, Michael Daly, Scott Messenger, Daniella DellaGiustina, Maurizio Pajola, Charles Brunet, Joshua L. Bandfield, J. Padilla, A. Janakus, M. Moreau, R. Garcia, R. A. Chicoine, P. Michel, P. Kaotira, K. S. Johnson, J. Forelli, G. Miller, K. Martin, I. Galinsky, S. Desjardins, Naru Hirata, Christine Hartzell, M. L. Jones, S. Hooven, D. Velez, R. Munoz, Carolyn M. Ernst, C. Emr, N. Martinez-Vlasoff, S. Bendall, R. Zellar, E. Church, Theodore Kareta, T. Warren, P. Wolff, V. Morrison, C. Bryan, S. Bhaskaran, N. Jones, D. Hauf, Jeremy Bauman, R. T. Daly, R. Olds, M. M. Westermann, D. K. Hamara, E. Audi, G. Johnston, Eric Palmer, Courtney Mario, Daniel P. Glavin, T. Haltigin, J. Cutts, Javier Licandro, Xiao-Duan Zou, H. L. Roper, Gregory A. Neumann, William M. Owen, S. Sugita, Y. H. Tang, Kevin Burke, H. L. Enos, D. Gallagher, William F. Bottke, K. Getzandanner, Philip R. Christensen, C. W. V. Wolner, K. Fleshman, D. Poland, J. P. Emery, M.M. Riehl, D. Fennell, D. Sallitt, A. D. Rogers, M. Fitzgibbon, John H. Jones, S. Mullen, S. Salazar, S. Oliver, A. T. Polit, J. Cerna, A. Praet, Mark E. Holdridge, E. M. Ibrahim, Coralie D. Adam, J. de León, Christopher J. Miller, M. Ryle, J. Lyzhoft, M. Loveridge, C. Hoekenga, Brent J. Bos, S. Anwar, K. Chaffin, Devin L. Schrader, B. Lovelace, Romy D. Hanna, C. D. Adam, G. L. Mehall, K. L. Donaldson Hanna, F. Merlin, B. Wright, Guy Libourel, L. F. Lim, N. Shultz, Dante S. Lauretta, K. Hanley, Beth E. Clark, L. Le Corre, K. Thomas-Keprta, Moses Milazzo, W. Hagee, B. Page, M. Fisher, E. McDonough, D. Trang, S. Clemett, A. Rubi, A. Ingegneri, Scott A. Sandford, D. Dean, J. Freemantle, Michael D. Smith, Christopher W. Haberle, L. Nguyen, M. Fulchignoni, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL), Centre de Mise en Forme des Matériaux (CEMEF), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], 010504 meteorology & atmospheric sciences, Rubble, Stiffness, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, [SDU]Sciences of the Universe [physics], engineering, medicine, General Earth and Planetary Sciences, Geotechnical engineering, medicine.symptom, Pile, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Geology, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

International audience

Published
2020
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4. S125: 10-DAY DECITABINE VS. CONVENTIONAL CHEMOTHERAPY ('3 + 7') FOLLOWED BY ALLOGRAFTING (HSCT) IN AML PATIENTS ≥60 YEARS: A RANDOMIZED PHASE III STUDY OF THE EORTC LEUKEMIA GROUP, GIMEMA, CELG, AND GMDS-SG

Author

M. Lübbert, P. Wijermans, M. Kicinski, S. Chantepie, W. van der Velden, R. Noppeney, L. Griskevicius, A. Neubauer, M. Crysandt, R. Vrhovac, M. Luppi, S. Fuhrmann, E. Audisio, A. Candoni, O. Legrand, R. Foà, G. Gaidano, D. van Lammeren-Venema, E. F. Posthuma, M. Hoogendoorn, A. Giraut, M. Stevens-Kroef, J. H. Jansen, E. Ammatuna, J.-P. Vilque, R. Wäsch, H. Becker, N. Blijlevens, U. Dührsen, F. Baron, S. Suciu, S. Amadori, A. Venditti, and G. Huls

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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5. S113: NATIONAL PEGASPARGASE-MODIFIED RISK-ORIENTED PROGRAM FOR PHILADELPHIA-NEGATIVE ADULT ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOBLASTIC LYMPHOMA (PH− ALL/LL). GIMEMA LAL 1913 FINAL RESULTS.

Author

R. Bassan, S. Chiaretti, I. Della Starza, O. Spinelli, A. Santoro, L. Elia, M. S. De Propris, A. M. Scattolin, F. Paoloni, M. Messina, E. Audisio, L. Marbello, E. Borlenghi, P. Zappasodi, C. Vetro, G. Martinelli, D. Mattei, N. Fracchiolla, M. Bocchia, P. De Fabritiis, M. Bonifacio, A. Candoni, V. Cassibba, P. Di Bartolomeo, G. Latte, S. Trappolini, A. Guarini, A. Vitale, P. Fazi, M. Vignetti, A. Rambaldi, and R. Foà

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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7. Advanced Pharmacy Practice Experiences in Pharmacogenomics Offered by US Pharmacy Programs.

Author

Gammal RS, Nguyen J, Audi E, Lee YM, Petry N, and Empey PE

Subjects
Cross-Sectional Studies, Humans, Pharmacogenetics, Preceptorship, Schools, Pharmacy, United States, Education, Pharmacy, Pharmacy, Students, Pharmacy
Abstract

Objective. To characterize advanced pharmacy practice experiences (APPEs) with a primary focus in pharmacogenomics at schools and colleges of pharmacy in the United States. Methods. This was a cross-sectional, multicenter, observational study of pharmacogenomics APPEs at US pharmacy schools. Directors of experiential education at 146 accredited schools of pharmacy were contacted by phone and asked if their school offered a pharmacogenomics APPE. The preceptors of pharmacogenomics APPEs identified by this phone screen were sent an email with a link to an online survey that asked about their APPE offerings. Results. Of the 142 schools of pharmacy that were successfully reached via phone, 40 (28%) offered an APPE with a primary focus in pharmacogenomics. Thirty unique APPEs with pharmacogenomics as a primary focus were identified. The total number of preceptors involved in the pharmacogenomics APPEs was 33: 19 (58%) faculty preceptors and 14 (42%) non-faculty preceptors. Twenty-three of the 30 pharmacogenomics APPEs completed the survey (77% response rate). The APPE sites were diverse and included academic medical centers, community health systems, pharmacogenomic testing laboratories, and schools of pharmacy. Each pharmacogenomics APPE accommodated an average of six students per year. The APPE activities varied across sites. Conclusion. Only a small number of US pharmacy schools offer an APPE with a primary focus in pharmacogenomics. These rotations are diverse in scope and precepted by faculty or non-faculty pharmacists. The Academy should pursue opportunities to increase experiential education in pharmacogenomics., (© 2020 American Association of Colleges of Pharmacy.)

Published
2020
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8. Novel pleiotropic BRCA2 pathogenic variants in Lebanese families.

Author

El-Khoury R, Hajj M, Khraibani J, Audi E, Monsef C, and Farra C

Subjects
Adult, Aged, Amino Acid Sequence, BRCA2 Protein chemistry, Base Sequence, Family, Female, Humans, Lebanon, Middle Aged, Open Reading Frames genetics, Pedigree, BRCA2 Protein genetics, Genetic Pleiotropy, Mutation genetics
Abstract

BRCA1 and BRCA2 associated pathogenic variants are the major cause of familial cases of early onset breast and ovarian cancers. Here we report two novel heterozygous pathogenic variants in exons 18 and 11 of the BRCA2 gene in two Lebanese families. The double nucleotide insertion c.8052_8053dupAA was identified in a 38-year-old Lebanese woman diagnosed with a breast cancer. The patient had a family history of affected first degree relatives. The double nucleotide deletion c.4342_4343delAA was identified in a 67-year-old woman with ovarian cancer. The patient came from a family marked by the occurrence of variable cancers. Her two daughters were also found to carry the deleterious variant. Both genetic aberrations result in a framing error that leads to a premature stop codon giving rise to unstable or truncated proteins. We further discuss two non-mutually exclusive potential scenarios related to the resulting haploinsufficiency and variant-specific dominant negative phenotype that might explain, at least in part, the variable expressivity associated with BRCA2 pathogenic variants., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
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9. The anti-ischaemic drug, eliprodil, blocks hyperactivity induced by intra-accumbens injection of spermine.

Author

Sanger DJ, Perrault G, and Audi E

Abstract

NMDA receptor mechanisms in the nucleus accumbens play an important role in the control of locomotor activity. Among the several binding sites associated with these receptors, the polyamine-sensitive sites have received relatively little attention. It has recently been shown, however, that the anti-ischaemic drug eliprodil NMDA antagonist effects probably mediated by activity at this polyamine site. In the present series of experiments the effects of injections of spermine and eliprodil into the nucleus accumbens of rats were investigated. Locomotor hyperactivity was produced by intra-accumbens injection of spermine, phencyclidine and AP7. Phencyclidine, but not AP7, produced a similar effect after systemic injection. Eliprodil did not increase locomotion after either intra-accumbens or i.p. administration. However, systemic injection of eliprodil (5, 10, 20mg/kg) produced a dose-related antagonism of hyperactivity induced by intra-accumbens spermine, but not by systemic or intra-accumbens injection of d-amphetamine. These results provide the first behavioural demonstration of the polyamine antagonist properties of eliprodil, and further emphasise the differences between the pharmacological profile of eliprodil and those of other NMDA antagonists.

Published
1995

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