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Objectives A method of continuous heart rate (HR) and blood pressure (BP) recording was used for the evaluation of the cardiovascular system parameters in participants of short-term (

C57Bl/6J mice were exposed to γ-radiation in a dose of 7.5 Gy. A week later, the experimental group received intravenous injection of extracellular vesicles isolated from the culture medium of human bone marrow multipotent mesenchymal stromal cells. Changes in the physiological parameters of animals were assessed by laser correlation spectroscopy, histological examination, cytometry, and by differential leukocyte count. In 3 and 6 weeks, the parameters of the experimental group occupied an intermediate position between the intact and irradiated groups or did not differ significantly from the parameters of the intact group. The rate and efficiency of recovery varied at different levels of organization. Reduction of damage caused by irradiation in a sublethal dose at different levels of organization of experimental animals was shown.

Prognostic express diagnosis of metabolic dysregulation was tested in highly qualified athletes engaged in various Olympic sports. The method is based on laser correlation spectroscopy (LCS) of biological fluids, which has widely been approved for use in medicine and evaluation of risks for natural and anthropogenic anomalies. Evaluating the risk for metabolic dysregulations with the relevant criteria will help to objectively estimate the efficiency of preventive actions in athletes.

Background. Limited data on adipose tissue zinc content in obesity exist. At the same time, the association between adipose tissue zinc content and metabolic parameters in dietary-induced obesity is poorly studied. Therefore, the primary objective of this study is to assess adipose tissue zinc content and its association with morphometric parameters, adipokine spectrum, proinfl ammatory cytokines, and apolipoprotein profi le in high fat fed Wistar rats. Material and methods. A total of 48 adult female Wistar rats were used in the present study. Rats were fed either control (10% of fat) or high fat diet (31.6% of fat). Adipose tissue zinc content was assessed using inductively coupled plasma mass spectrometry. Rats' serum was examined for adiponectin, leptin, insulin, interleukin-6, and tumor necrosis factor-α using enzyme-linked immunosorbent assay kits. Serum glucose and apolipoprotein spectrum were also evaluated. Results. High fat feeding resulted in a signifi cant 34% decrease in adipose tissue zinc content in comparison to the control values. Fat pad zinc levels were signifi cantly inversely associated with morphometric param- eters, circulating leptin, insulin, tumor necrosis factor-α levels and HOMA-IR values. At the same time, a signifi cant correlation with apolipoprotein A1 concentration was observed. Conclusion. Generally, the obtained data indicate that (1) high fat feeding results in decreased adipose tis- sue zinc content; (2) adipose tissue zinc content is tightly associated with excessive adiposity, infl ammation, insulin resistance and potentially atherogenic changes.

The article considers interaction of nano-particles of titan oxide and blood serum of patients with verified diagnoses of "myasthenia" and "allergy". The analysis of solution of nano-powder of titan oxide using technique of laser correlated spectrometry demonstrated that main input into light scattering is made by particles with radius of 4.64-8.42 nm. The data concerning dimensions of particles received with laser correlated spectrometry matches data of analysis of these particles with various physical techniques. The nano-particles of titan oxide stabilized with phosphoric acid at interaction with blood serum cause development and sedimentation of complexes with albumins and globulins. The interaction of nano-particles of titan oxide with blood serum of patients with myasthenia results in elimination from it the significant percentage (40%) of circulating immune complexes. In blood serum of patients with bronchial asthma, nano-particles of titan oxide bind proteins of small size mainly.

The high level of physical activity is known to contribute to the harmonious development of children and adolescents: moreover; it is a factor promoting prevention of hypodynamia. The low level of physical activity is a risk factor for the development of many non-communicable diseases. However, physical education is not considered by many students as an attractive subject.The objective of the present study was the enhancement of the motivational aspects of physical activity for the prevention of hypodynamia among students.Physical education of the students was carried out with the use of the standard and modified methods. A total of 206 students (including 133 girls and 73 boys) at the mean age of 17.5±1.5 years were available for the examination. The study was conducted before the intervention (1st year) after the termination of the physical culture lessons envisaged by the academic curriculum (3rd year). The evaluation of the physical conditions and fitness of the students was conducted on the basis of the Russian Physical Culture and Sport Complex (GTO), bioimpedance analysis making use of the 'Medass' ABC-01 device; the functional reserves of the organism were assessed by means of hardware-software programs; the changes in food preferences were estimated on the basis of the FLLANK, questionnaire preliminarily adapted to the specific conditions of this country, and the characteristics of the metabolic processes were evaluated by laser correlation spectroscopy.Dynamics of the successful performance of the GTO normatives in the girls manifested itself in the in reduction of time they spent to run the 100 meter distance; the same was true for the boys who had to overcome the distance of 3000 meters. The students of both sexes became capable of increasing the number of repetitions of crunch and jumping rope exercises. The basal metabolism in the girls was increased within one year after the start of classes, and in the boys two years after the onset of the exercises; simultaneously, the positive changes in the metabolic profile were documented in the students of either sex. No adverse events related to the application of the modified training methods were recorded.An important aspect of the present study was the impact of new methods of teaching physical education on the composite body composition. The modified methods were found to shift dietary preferences and metabolic processes in the body of the students after the termination of the educational program.Обоснование. Высокий уровень физической активности способствует гармоничному развитию детей и подростков и является фактором профилактики гиподинамии, которая приводит к развитию многих неинфекционных заболеваний. Однако физическая культура не рассматривается многими учащимися как привлекательный предмет. Цель - оценить эффективность модифицированной методики занятий физической культурой для профилактики гиподинамии у студентов. Материал и методы. Занятия физической культурой у студентов проводились по стандартной и модифицированной методикам. Были обследованы 206 студентов (133 девушки и 73 юноши, в возрасте 17,5±1,5 года). Исследование проводили до начала вмешательства (1-й курс) и через 1 год после прекращения занятий физической культурой в рамках учебной программы (3-й курс). Оценку физической подготовленности студентов проводили на основании норм Всероссийского физкультурно-спортивного комплекса 'Готов к труду и обороне' (ГТО), биоимпедансного анализа на приборе Медасс ABC-01, функциональные резервы организма оценивали с помощью аппаратно-программных комплексов, изменение пищевых предпочтений изучали на основании опросника FLLANK, ранее адаптированного для Российской Федерации. Для оценки направленности обменных процессов был избран метод лазерной корреляционной спектроскопии. Результаты. Динамика успешности выполнения нормативов ГТО заключалась у девушек в сокращении времени бега на преодоление дистанции 100 м, у юношей - 3000 м, а также у обоих полов в увеличении количества повторений упражнений на пресс и прыжков со скакалкой. У девушек уровень основного обмена возрастает через 1 год после начала занятий, а у юношей - через 2 года, одновременно наблюдались позитивные изменения в метаболическом профиле. Нежелательных явлений, связанных с проведением модифицированной методики, не отмечено. Заключение. Важным аспектом является влияние новой методики преподавания физической культуры на композитный состав тела. Характерно изменение пищевых предпочтений и метаболических процессов в организме студентов после занятий по модифицированной методике.

The preliminary results of the 1st session of Russian "PHOENIX" long-term space experiment are presented. The survival of dried human lymphocytes and mouse bone marrow cells in 199 days space flight is studied. The degree of DNA fragmentation is analysed for samples flown in different ISS compartments. It is shown that biological data correlates with the results of space radiation dose measurements.

Locally compact groups with a coalgebraic lattice of closed subgroups are investigated and Abelian and zero-dimensional nilpotent groups with a coalgebraic lattice of closed subgroups are described.