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1. Polygenic risk scores for autoimmune related diseases are significantly different in cancer exceptional responders

Author: Siyuan Chen, Amelia L. M. Tan, Maria C. Saad Menezes, Jenny F. Mao, Cassandra L. Perry, Margaret E. Vella, Vinayak V. Viswanadham, Shilpa Kobren, Susanne Churchill, and Isaac S. Kohane
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract A small number of cancer patients respond exceptionally well to therapies and survive significantly longer than patients with similar diagnoses. Profiling the germline genetic backgrounds of exceptional responder (ER) patients, with extreme survival times, can yield insights into the germline polymorphisms that influence response to therapy. As ERs showed a high incidence in autoimmune diseases, we hypothesized the differences in autoimmune disease risk could reflect the immune background of ERs and contribute to better cancer treatment responses. We analyzed the germline variants of 51 ERs using polygenic risk score (PRS) analysis. Compared to typical cancer patients, the ERs had significantly elevated PRSs for several autoimmune-related diseases: type 1 diabetes, hypothyroidism, and psoriasis. This indicates that an increased genetic predisposition towards these autoimmune diseases is more prevalent among the ERs. In contrast, ERs had significantly lower PRSs for developing inflammatory bowel disease. The left-skew of type 1 diabetes score was significant for exceptional responders. Variants on genes involved in the T1D PRS model associated with cancer drug response are more likely to co-occur with other variants among ERs. In conclusion, ERs exhibited different risks for autoimmune diseases compared to typical cancer patients, which suggests that changes in a patient’s immune set point or immune surveillance specificity could be a potential mechanistic link to their exceptional response. These findings expand upon previous research on immune checkpoint inhibitor-treated patients to include those who received chemotherapy or radiotherapy.
Published: 2024
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2. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortiumResearch in context

Author: Francesca Sperotto, Alba Gutiérrez-Sacristán, Simran Makwana, Xiudi Li, Valerie N. Rofeberg, Tianxi Cai, Florence T. Bourgeois, Gilbert S. Omenn, David A. Hanauer, Carlos Sáez, Clara-Lea Bonzel, Emily Bucholz, Audrey Dionne, Matthew D. Elias, Noelia García-Barrio, Tomás González González, Richard W. Issitt, Kate F. Kernan, Jessica Laird-Gion, Sarah E. Maidlow, Kenneth D. Mandl, Taha Mohseni Ahooyi, Cinta Moraleda, Michele Morris, Karyn L. Moshal, Miguel Pedrera-Jiménez, Mohsin A. Shah, Andrew M. South, Anastasia Spiridou, Deanne M. Taylor, Guillaume Verdy, Shyam Visweswaran, Xuan Wang, Zongqi Xia, Joany M. Zachariasse, Jane W. Newburger, Paul Avillach, James R. Aaron, Atif Adam, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, François Angoulvant, Li LLJ. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Vidul Ayakulangara Panickan, Paula S. Azevedo, Rafael Badenes, James Balshi, Ashley Batugo, Brendin R. Beaulieu-Jones, Brett K. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Riccardo Bellazzi, Vincent Benoit, Michele Beraghi, José Luis Bernal-Sobrino, Mélodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martínez, Martin Boeker, John Booth, Silvano Bosari, Robert L. Bradford, Gabriel A. Brat, Stéphane Bréant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Anita Burgun, Mario Cannataro, Aldo Carmona, Anna Maria Cattelan, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, Luca Chiovato, Lorenzo Chiudinelli, Kelly Cho, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sébastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermúdez, Jaime Cruz-Rojo, Arianna Dagliati, Mohamad Daniar, Christel Daniel, Priyam Das, Batsal Devkota, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Rachel SJ. Goh, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Pietro H. Guzzi, Larry Han, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Yuk-Lam Ho, John H. Holmes, Jacqueline P. Honerlaw, Chuan Hong, Kenneth M. Huling, Meghan R. Hutch, Anne Sophie Jannot, Vianney Jouhet, Mundeep K. Kainth, Kernan F. Kate, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Daniel A. Key, Katie Kirchoff, Jeffrey G. Klann, Isaac S. Kohane, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Ne Hooi Will Loh, Qi Long, Sara Lozano-Zahonero, Yuan Luo, Kristine E. Lynch, Sadiqa Mahmood, Adeline Makoudjou, Alberto Malovini, Chengsheng Mao, Anupama Maram, Monika Maripuri, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Diego R. Mazzotti, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Bertrand Moal, Jason H. Moore, Jeffrey S. Morris, Sajad Mousavi, Danielle L. Mowery, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Antoine Neuraz, Jane Newburger, Kee Yuan Ngiam, Wanjiku FM. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Lav P. Patel, Ashley C. Pfaff, Emily R. Pfaff, Danielle Pillion, Sara Pizzimenti, Tanu Priya, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Nekane Romero-Garcia, Paula Rubio-Mayo, Paolo Sacchi, Elisa Salamanca, Malarkodi Jebathilagam Samayamuthu, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C.C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Emily R. Schriver, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Zachary H. Strasser, Amelia LM. Tan, Bryce W.Q. Tan, Byorn W.L. Tan, Suzana E. Tanni, Ana I. Terriza-Torres, Valentina Tibollo, Patric Tippmann, Emma MS. Toh, Carlo Torti, Enrico M. Trecarichi, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Jill-Jênn Vie, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Demian Wassermann, Griffin M. Weber, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Janet J. Zahner, Alberto Zambelli, Harrison G. Zhang, Daniela Zöller, Valentina Zuccaro, and Chiara Zucco
Subjects: Multisystem inflammatory syndrome, Paediatric inflammatory multisystem syndrome, COVID-19, SARS-CoV-2, Variants, Pediatrics, Medicine (General), R5-920
Abstract: Summary: Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection. It remains unclear how MIS-C phenotypes vary across SARS-CoV-2 variants. We aimed to investigate clinical characteristics and outcomes of MIS-C across SARS-CoV-2 eras. Methods: We performed a multicentre observational retrospective study including seven paediatric hospitals in four countries (France, Spain, U.K., and U.S.). All consecutive confirmed patients with MIS-C hospitalised between February 1st, 2020, and May 31st, 2022, were included. Electronic Health Records (EHR) data were used to calculate pooled risk differences (RD) and effect sizes (ES) at site level, using Alpha as reference. Meta-analysis was used to pool data across sites. Findings: Of 598 patients with MIS-C (61% male, 39% female; mean age 9.7 years [SD 4.5]), 383 (64%) were admitted in the Alpha era, 111 (19%) in the Delta era, and 104 (17%) in the Omicron era. Compared with patients admitted in the Alpha era, those admitted in the Delta era were younger (ES −1.18 years [95% CI −2.05, −0.32]), had fewer respiratory symptoms (RD −0.15 [95% CI −0.33, −0.04]), less frequent non-cardiogenic shock or systemic inflammatory response syndrome (SIRS) (RD −0.35 [95% CI −0.64, −0.07]), lower lymphocyte count (ES −0.16 × 109/uL [95% CI −0.30, −0.01]), lower C-reactive protein (ES −28.5 mg/L [95% CI −46.3, −10.7]), and lower troponin (ES −0.14 ng/mL [95% CI −0.26, −0.03]). Patients admitted in the Omicron versus Alpha eras were younger (ES −1.6 years [95% CI −2.5, −0.8]), had less frequent SIRS (RD −0.18 [95% CI −0.30, −0.05]), lower lymphocyte count (ES −0.39 × 109/uL [95% CI −0.52, −0.25]), lower troponin (ES −0.16 ng/mL [95% CI −0.30, −0.01]) and less frequently received anticoagulation therapy (RD −0.19 [95% CI −0.37, −0.04]). Length of hospitalization was shorter in the Delta versus Alpha eras (−1.3 days [95% CI −2.3, −0.4]). Interpretation: Our study suggested that MIS-C clinical phenotypes varied across SARS-CoV-2 eras, with patients in Delta and Omicron eras being younger and less sick. EHR data can be effectively leveraged to identify rare complications of pandemic diseases and their variation over time. Funding: None.
Published: 2023
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3. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort studyResearch in Context

Author: Arianna Dagliati, Zachary H. Strasser, Zahra Shakeri Hossein Abad, Jeffrey G. Klann, Kavishwar B. Wagholikar, Rebecca Mesa, Shyam Visweswaran, Michele Morris, Yuan Luo, Darren W. Henderson, Malarkodi Jebathilagam Samayamuthu, Bryce W.Q. Tan, Guillame Verdy, Gilbert S. Omenn, Zongqi Xia, Riccardo Bellazzi, Shawn N. Murphy, John H. Holmes, Hossein Estiri, James R. Aaron, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, François Angoulvant, Li L.L.J. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Paul Avillach, Paula S. Azevedo, James Balshi, Brett K. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Vincent Benoit, Michele Beraghi, José Luis Bernal-Sobrino, Mélodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martínez, Clara-Lea Bonzel, John Booth, Silvano Bosari, Florence T. Bourgeois, Robert L. Bradford, Gabriel A. Brat, Stéphane Bréant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Emily Bucholz, Anita Burgun, Tianxi Cai, Mario Cannataro, Aldo Carmona, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, Luca Chiovato, Lorenzo Chiudinelli, Kelly Cho, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sébastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermúdez, Jaime Cruz-Rojo, Mohamad Daniar, Christel Daniel, Priyam Das, Batsal Devkota, Audrey Dionne, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Noelia García- Barrio, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Alba Gutiérrez-Sacristán, Larry Han, David A. Hanauer, Christian Haverkamp, Derek Y. Hazard, Bing He, Martin Hilka, Yuk-Lam Ho, Chuan Hong, Kenneth M. Huling, Meghan R. Hutch, Richard W. Issitt, Anne Sophie Jannot, Vianney Jouhet, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Daniel A. Key, Katie Kirchoff, Isaac S. Kohane, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Trang T. Le, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Ne Hooi Will Loh, Qi Long, Sara Lozano-Zahonero, Kristine E. Lynch, Sadiqa Mahmood, Sarah E. Maidlow, Adeline Makoudjou, Alberto Malovini, Kenneth D. Mandl, Chengsheng Mao, Anupama Maram, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Bertrand Moal, Taha Mohseni Ahooyi, Jason H. Moore, Cinta Moraleda, Jeffrey S. Morris, Karyn L. Moshal, Sajad Mousavi, Danielle L. Mowery, Douglas A. Murad, Thomas P. Naughton, Carlos Tadeu Breda Neto, Antoine Neuraz, Jane Newburger, Kee Yuan Ngiam, Wanjiku F.M. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Lav P. Patel, Miguel Pedrera-Jiménez, Emily R. Pfaff, Ashley C. Pfaff, Danielle Pillion, Sara Pizzimenti, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Sáez, Elisa Salamanca, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C.C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Emily R. Schriver, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Andrew M. South, Anastasia Spiridou, Amelia L.M. Tan, Byorn W.L. Tan, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Valentina Tibollo, Patric Tippmann, Emma M.S. Toh, Carlo Torti, Enrico M. Trecarichi, Yi-Ju Tseng, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Guillaume Verdy, Jill-Jênn Vie, Michele Vitacca, Lemuel R. Waitman, Xuan Wang, Demian Wassermann, Griffin M. Weber, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Alberto Zambelli, Harrison G. Zhang, Daniela Zo¨ller, Valentina Zuccaro, and Chiara Zucco
Subjects: Post-acute sequelae of SARS-CoV-2, PASC, COVID-19, SARS-CoV-2, Electronic health records, Medicine (General), R5-920
Abstract: Summary: Background: Characterizing Post-Acute Sequelae of COVID (SARS-CoV-2 Infection), or PASC has been challenging due to the multitude of sub-phenotypes, temporal attributes, and definitions. Scalable characterization of PASC sub-phenotypes can enhance screening capacities, disease management, and treatment planning. Methods: We conducted a retrospective multi-centre observational cohort study, leveraging longitudinal electronic health record (EHR) data of 30,422 patients from three healthcare systems in the Consortium for the Clinical Characterization of COVID-19 by EHR (4CE). From the total cohort, we applied a deductive approach on 12,424 individuals with follow-up data and developed a distributed representation learning process for providing augmented definitions for PASC sub-phenotypes. Findings: Our framework characterized seven PASC sub-phenotypes. We estimated that on average 15.7% of the hospitalized COVID-19 patients were likely to suffer from at least one PASC symptom and almost 5.98%, on average, had multiple symptoms. Joint pain and dyspnea had the highest prevalence, with an average prevalence of 5.45% and 4.53%, respectively. Interpretation: We provided a scalable framework to every participating healthcare system for estimating PASC sub-phenotypes prevalence and temporal attributes, thus developing a unified model that characterizes augmented sub-phenotypes across the different systems. Funding: Authors are supported by National Institute of Allergy and Infectious Diseases, National Institute on Aging, National Center for Advancing Translational Sciences, National Medical Research Council, National Institute of Neurological Disorders and Stroke, European Union, National Institutes of Health, National Center for Advancing Translational Sciences.
Published: 2023
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4. Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort studyResearch in context

Author: Byorn W.L. Tan, Bryce W.Q. Tan, Amelia L.M. Tan, Emily R. Schriver, Alba Gutiérrez-Sacristán, Priyam Das, William Yuan, Meghan R. Hutch, Noelia García Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zöller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam, James R. Aaron, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, François Angoulvant, Li L.L.J. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Vidul Ayakulangara Panickan, Paula S. Azevedo, James Balshi, Brett K. Beaulieu-Jones, Brendin R. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Vincent Benoit, Michele Beraghi, José Luis Bernal-Sobrino, Mélodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martínez, Martin Boeker, John Booth, Silvano Bosari, Florence T. Bourgeois, Robert L. Bradford, Stéphane Bréant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Emily Bucholz, Anita Burgun, Mario Cannataro, Aldo Carmona, Anna Maria Cattelan, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sébastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermúdez, Jaime Cruz-Rojo, Mohamad Daniar, Christel Daniel, Batsal Devkota, Audrey Dionne, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Noelia García-Barrio, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Tomás González González, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Pietro H. Guzzi, Larry Han, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Jacqueline P. Honerlaw, Kenneth M. Huling, Richard W. Issitt, Anne Sophie Jannot, Vianney Jouhet, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Kate F. Kernan, Daniel A. Key, Katie Kirchoff, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Trang T. Le, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Qi Long, Sara Lozano-Zahonero, Kristine E. Lynch, Sadiqa Mahmood, Simran Makwana, Kenneth D. Mandl, Chengsheng Mao, Anupama Maram, Monika Maripuri, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Diego R. Mazzotti, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Taha Mohseni Ahooyi, Jason H. Moore, Cinta Moraleda, Jeffrey S. Morris, Karyn L. Moshal, Sajad Mousavi, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Jane Newburger, Wanjiku F.M. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Miguel Pedrera-Jiménez, Ashley C. Pfaff, Emily R. Pfaff, Danielle Pillion, Sara Pizzimenti, Tanu Priya, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Sáez, Elisa Salamanca, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C.C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Francesca Sperotto, Anastasia Spiridou, Zachary H. Strasser, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Emma M.S. Toh, Carlo Torti, Enrico M. Trecarichi, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Jill-Jênn Vie, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Xuan Wang, Demian Wassermann, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, Joany M. Zachariasse, Janet J. Zahner, Alberto Zambelli, Valentina Zuccaro, and Chiara Zucco
Subjects: COVID-19, Acute kidney injury, SARS-CoV-2, Chronic kidney disease, Electronic health records, Medicine (General), R5-920
Abstract: Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p
Published: 2023
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5. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality.

Author: Griffin M. Weber, Chuan Hong, Zongqi Xia, Nicolas Paris, Miguel Pedrera-Jiménez, Ashley C. Pfaff, Emily R. Pfaff, Danielle Pillion, Sara Pizzimenti, Hans-Ulrich Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Sáez, Elisa Salamanca, Malarkodi Jebathilagam Samayamuthu, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C. C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Jürgen Schüttler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Andrew M. South, Francesca Sperotto, Zachary H. Strasser, Bryce W. Q. Tan, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Patric Tippmann, Emma M. S. Toh, Yi-Ju Tseng, Andrew K. Vallejos, Gaël Varoquaux, Margaret E. Vella, Guillaume Verdy, Jill-Jênn Vie, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Demian Wassermann, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Alberto Zambelli, Harrison G. Zhang, Daniela Zöller, Valentina Zuccaro, and Chiara Zucco
Published: 2022
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6. Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

Author: Byorn W.L. Tan, Bryce W.Q. Tan, Amelia L.M. Tan, Emily R. Schriver, Alba Gutiérrez-Sacristán, Priyam Das, William Yuan, Meghan R. Hutch, Noelia García Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zöller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam, James R. Aaron, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, François Angoulvant, Li L.L.J. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Vidul Ayakulangara Panickan, Paula S. Azevedo, James Balshi, Brett K. Beaulieu-Jones, Brendin R. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Vincent Benoit, Michele Beraghi, José Luis Bernal-Sobrino, Mélodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martínez, Martin Boeker, John Booth, Silvano Bosari, Florence T. Bourgeois, Robert L. Bradford, Stéphane Bréant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Emily Bucholz, Anita Burgun, Mario Cannataro, Aldo Carmona, Anna Maria Cattelan, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sébastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermúdez, Jaime Cruz-Rojo, Mohamad Daniar, Christel Daniel, Batsal Devkota, Audrey Dionne, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Noelia García-Barrio, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Tomás González González, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Pietro H. Guzzi, Larry Han, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Jacqueline P. Honerlaw, Kenneth M. Huling, Richard W. Issitt, Anne Sophie Jannot, Vianney Jouhet, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Kate F. Kernan, Daniel A. Key, Katie Kirchoff, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Trang T. Le, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Qi Long, Sara Lozano-Zahonero, Kristine E. Lynch, Sadiqa Mahmood, Simran Makwana, Kenneth D. Mandl, Chengsheng Mao, Anupama Maram, Monika Maripuri, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Diego R. Mazzotti, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Taha Mohseni Ahooyi, Jason H. Moore, Cinta Moraleda, Jeffrey S. Morris, Karyn L. Moshal, Sajad Mousavi, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Jane Newburger, Wanjiku F.M. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Miguel Pedrera-Jiménez, Ashley C. Pfaff, Emily R. Pfaff, Danielle Pillion, Sara Pizzimenti, Tanu Priya, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Sáez, Elisa Salamanca, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C.C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Francesca Sperotto, Anastasia Spiridou, Zachary H. Strasser, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Emma M.S. Toh, Carlo Torti, Enrico M. Trecarichi, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Jill-Jênn Vie, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Xuan Wang, Demian Wassermann, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, Joany M. Zachariasse, Janet J. Zahner, Alberto Zambelli, Valentina Zuccaro, and Chiara Zucco
Subjects: General Medicine
Abstract: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking.A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021.Advanced age (HR 2.77, 95%CI 2.53-3.04, p 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI.COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery.Authors are supported by various funders, with full details stated in the acknowledgement section.
Published: 2022

7. Automated identification and quality measurement for pediatric convulsive status epilepticus

Author: Zachary M. Grinspan, David L. Hess-Homeier, Adam E Vella, Natasha Basma, and Karishma M. Parikh
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Drug Resistant Epilepsy, Multivariate analysis, Status epilepticus, Time-to-Treatment, Cohort Studies, 03 medical and health sciences, Epilepsy, Automation, Benzodiazepines, 0302 clinical medicine, Status Epilepticus, Interquartile range, Medicine, Humans, Child, Quality Indicators, Health Care, business.industry, Data Collection, Gold standard, Infant, Emergency department, medicine.disease, 030104 developmental biology, Neurology, Child, Preschool, Emergency medicine, Cohort, Observational study, Anticonvulsants, Female, Neurology (clinical), medicine.symptom, business, Emergency Service, Hospital, 030217 neurology & neurosurgery
Abstract: Objective Treatment delays for refractory convulsive status epilepticus (RCSE) are associated with worse outcomes. In the United States, treatment for pediatric RCSE is slower than guidelines recommend. To address this gap, the American Academy of Neurology and Child Neurology Society (AAN/CNS) developed a quality measure: the percentage of RCSE patients that receive third-line treatment within 60 minutes. We aimed to develop computable phenotypes for convulsive status epilepticus (CSE) and RCSE to automate calculation of the quality measure. Methods From an observational cohort of children presenting to the emergency department for seizures or epilepsy, we identified presentations of RCSE and its precursors: CSE and benzodiazepine-resistant status epilepticus (BRSE). These served as a gold standard for computable phenotype development. Using multivariate analyses, we constructed and evaluated statistical models for case identification. We then evaluated adherence to the AAN/CNS RCSE quality measure. Results From 664 charts, we identified 56 patients with CSE, 36 with BRSE, and 18 with RCSE. Four predictors were used: International Classification of Diseases (ICD) codes, and receiving first-, second-, or third-line agents shortly after presentation to the emergency department (ED). Combinations of these predictors identified CSE with 84% sensitivity and 81% positive predictive value (PPV), BRSE with 67% sensitivity and 89% PPV, and RCSE with 94% sensitivity and 85% PPV. Median (interquartile range [IQR]) time to treatment for first-line agent was 13 (5-27) minutes for CSE, second-line for BRSE was 24 (9.5-43.5) minutes, and third-line for RCSE was 52 (27-87) minutes. Sixty percent of RCSE patients received a third-line agent within 60 minutes of ED arrival. Significance RCSE and its precursors can be identified automatically with high fidelity allowing automated calculation of time to treatment and the RCSE quality measure. This has the potential to facilitate quality improvement work and improve care for RCSE.
Published: 2020

8. Commento all'art. 21 T.u.b.

Author: Costi Renzo e Vella Francesco, Palmieri, Marco, palmieri marco (ORCID:0000-0001-8263-336X), Costi Renzo e Vella Francesco, Palmieri, Marco, and palmieri marco (ORCID:0000-0001-8263-336X)
Abstract: Commento all'art. 21 T.u.b.
Published: 2019

9. Commento all'art. 19 T.u.b.

Author: Costi Renzo e Vella Francesco, Palmieri, Marco, marco palmieri (ORCID:0000-0001-8263-336X), Costi Renzo e Vella Francesco, Palmieri, Marco, and marco palmieri (ORCID:0000-0001-8263-336X)
Abstract: Commento all'art. 19 T.u.b., Commentary to art. 19 Banking Law
Published: 2019

10. 4CPS-209 A clinical pharmacist-led medication reconciliation service in geriatric patients upon admission to hospital

Author: E Vella Seychell and Anita Elaine Weidmann
Subjects: Service (business), medicine.medical_specialty, business.industry, Patient demographics, Alimentary tract, World health, Clinical pharmacy, Medication error, Medication Reconciliation, Intervention (counseling), Emergency medicine, Medicine, business, Section 4: Clinical pharmacy services
Abstract: BACKGROUND: At the points of admission and discharge from hospital, patient or medication-related factors such as older age and an increased number of drugs can lead to medication errors.(1) In 2006, the World Health Organisation initiated the High 5 s Project where it recommended medication reconciliation to prevent medication errors at transition points.(2) PURPOSE: To implement and evaluate a clinical pharmacist-led medication reconciliation service in geriatric patients upon admission to hospital, in terms of frequency, type and potential severity of the medication errors identified. MATERIAL AND METHODS: Medication reconciliation interviews were conducted to record the best possible list of all the medications a patient was taking upon admission to hospital. This list was then compared with the drug history initially recorded by the physician. Any discrepancies were considered as medication errors. Errors were categorised by type and therapeutic group. An expert panel rated each medication error for its potential severity. A secondary outcome included studying the relationship between the number of errors and patient demographics or medication-related factors. RESULTS: A total of 154 patients were eligible for inclusion; 136 (88.31%) patients had at least one error. Four hundred and ninety-eight medication errors (mean of 3.23 errors per patient) were determined with the most common type being that of drug omission (n=252, 50.6%). The therapeutic group with the highest number of errors was that of the alimentary tract and metabolism (n=132, 26.51%). With regards to severity, 208 (41.77%) of the medication errors potentially required monitoring or intervention to prevent harm while 33 (6.63%) had the potential to cause harm. Medication errors were found to be correlated with the number of drugs at admission and total sources of information (p
Published: 2018

11. Structural and Functional Changes in Human Insulin Induced by the Lipid Peroxidation Byproducts 4-Hydroxy-2-nonenal and 4-Hydroxy-2-hexenal

Author: Christophe O. Soulage, Michel Becchi, Laurent Soulère, Nicolas J. Pillon, Roxane E. Vella, Michel Lagarde, Mécanisme Moléculaire du Diabète (MMD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA), Université de Lyon (COMUE), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM), Institut National des Sciences Appliquees de Lyon (INSA-Lyon), and Ministere de l'Education Nationale, de la Recherche et de la Technologie
Subjects: Models, Molecular, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Toxicology, medicine.disease_cause, GLUCOSE, law.invention, Lipid peroxidation, Mice, chemistry.chemical_compound, 0302 clinical medicine, law, Insulin, OXIDATIVE STRESS, Peptide sequence, chemistry.chemical_classification, 0303 health sciences, PROTEIN MODIFICATION, General Medicine, Recombinant Proteins, Biochemistry, Recombinant DNA, BETA-CELL MASS, Polyunsaturated fatty acid, medicine.medical_specialty, Molecular Sequence Data, 2-Nonenal, Cell Line, 03 medical and health sciences, ADDUCTS, 3T3-L1 Cells, Internal medicine, medicine, Animals, Humans, Amino Acid Sequence, 030304 developmental biology, Aldehydes, FATTY-ACID, MASS-SPECTROMETRIC CHARACTERIZATION, Rats, ENZYME GENE-EXPRESSION, HNE, Endocrinology, chemistry, Cell culture, Lipid Peroxidation, RESISTANCE, 030217 neurology & neurosurgery, Oxidative stress
Abstract: International audience; Lipid peroxidation produces many reactive byproducts including 4-hydroxy-2-hexenal (HHE) and 4-hydroxy-2-nonenal (HNE) derived from the peroxidation of n-3 and n-6 polyunsaturated fatty acids, respectively. HNE and HHE can modify circulating biomolecules through the formation of covalent adducts. It remains, however, unknown whether HHE and HNE could induce functional and structural changes in the insulin molecule, which may in turn be pivotal in the development of insulin resistance and diabetes. Recombinant human insulin was incubated in the presence of HHE or HNE, and the formation of covalent adducts on insulin was analyzed by mass spectrometry analysis. Insulin tolerance test in mice and stimulation of glucose uptake by 3T3 adipocytes and L6 muscle cells were used to evaluate the biological efficiency of adducted insulin compared with the native one. One to 5 adducts were formed on insulin through Michael adduction, involving histidine residues. Glucose uptake in 3T3-L1 and L6C5 cells as well as the hypoglycemic effect in mice was significantly reduced after treatment with adducted insulin compared to native insulin. The formation of HNE- and HHE-Michael adducts significantly disrupts the biological activity of insulin. These structural and functional abnormalities of the insulin molecule might contribute to the pathogenesis of insulin resistance.
Published: 2011
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12. 4CPS-209 A clinical pharmacist-led medication reconciliation service in geriatric patients upon admission to hospital

Author: Seychell, E Vella, primary and Weidmann, A, additional
Published: 2018
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13. Pollution atmosphérique et diabète… Quel lien possible ? Une exposition expérimentale à l’ozone chez le rat induit une insulino-résistance périphérique

Author: Alain Géloën, Christophe O. Soulage, and Roxane E. Vella
Subjects: Gynecology, Atmospheric Science, medicine.medical_specialty, business.industry, Medicine, Insulino resistance, business, Pollution
Abstract: L’incidence des pathologies metaboliques, tel le diabete de type 2, a connu une importante progression au cours des dernieres decades. Des etudes epidemiologiques recentes suggerent que certains polluants atmospheriques pourraient jouer un role dans le developpement et la progression de l’insulino-resistance, associee au diabete de type 2. L’ozone, un polluant photochimique majeur des zones urbaines, est associe a des concentrations augmentees de glucose et d’insuline plasmatiques a jeun ; cependant, de nombreux aspects de cette association restent a elucider. Des resultats recents obtenus dans notre laboratoire et publies dans la revue americaine Diabetes (Vella et al., 2015) indiquent qu’une exposition experimentale a l’ozone induit chez le rongeur de laboratoire un etat d’insulino-resistance, prelude au developpement d’un diabete de type 2. L’ozone etant trop reactif pour traverser la barriere alveolo-capillaire, la toxicite systemique de l’ozone resulte de la production dans les poumons de mediateurs du stress oxydant et dont les effets deleteres sur les tissus peripheriques ont pu etre demontres. Ces travaux mettent en exergue un lien entre pollution et diabete et suggerent le role de facteurs environnementaux dans l’etiologie de cette maladie pour l’heure essentiellement attribuee a des facteurs nutritionnels ou comportementaux.
Published: 2016
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14. Predictors of fluid resuscitation in pediatric trauma patients

Author: Craig McElderry, Adam E. Vella, and Vincent J. Wang
Subjects: Male, medicine.medical_specialty, Resuscitation, Adolescent, Decision Making, Population, Catheterization, Peripheral, Epidemiology, medicine, Humans, Child, education, Retrospective Studies, education.field_of_study, business.industry, Infant, Retrospective cohort study, medicine.disease, Surgery, Advanced trauma life support, Traumatic injury, Child, Preschool, Emergency medicine, Emergency Medicine, Fluid Therapy, Wounds and Injuries, Female, business, Foot (unit), Forecasting, Pediatric trauma
Abstract: Advanced Trauma Life Support (ATLS) is accepted as the standard for the first hours of trauma care. However, ATLS is designed primarily for adults. In children, vascular access can be difficult and time-consuming. Due to the differences in the epidemiology of children suffering traumatic injury, they may not require aggressive fluid resuscitation. The objective of the study was to establish predictors of fluid resuscitation, and to determine whether all pediatric Level I Trauma victims require two intravenous catheters. Medical charts of all patients aged18 years meeting Level I Trauma criteria who presented to Childrens Hospital Los Angeles (CHLA) between January 1 and December 31, 1999 were retrospectively reviewed. There were 152 patients reviewed with a median age of 6 years (range 4 months to 17 years); 64% were boys. The mechanism of injury was motor vehicle crash 49%, fall 37%, crush 8%, gunshot 5%, and knife 1%. Injuries included closed head 88%, penetrating abdomen/chest 6%, and other 6%. Vital signs over time showed no change in 59%, got better in 34%, and got worse in 7%. Fluid resuscitation included no bolus in 70%, 1 bolus in 20%, 2 boluses in 7%,2 boluses in 3%. The ICU admitted 23%, 12% were intubated, survival was 95%, and 59% received a prehospital i.v. The i.v. #1 site: antecubital 51%, hand 41%, foot 5%, femoral 1%. The i.v. #2 site: hand 30%, antecubital 20%, foot 2%, none 48%. T test showed no statistically significant differences in fluid resuscitation or second i.v. placement based on the mechanism of injury. T test for unequal variances showed a statistically significant difference in means with p0.001 for second i.v. placement as compared with only i.v. fluid amount, age, and Injury Severity Score (ISS). Revised Trauma Score was the only predictor of worsening of vital signs (logistic regression [LR], p0.001). Age was the only predictor of second i.v. placement (LR, p0.03). ISS was the only predictor of a bolus being given (LR, p0.01). In our study, blunt trauma occurred in 90% of children, with 10% requiring1 fluid bolus. ISS was the only predictor of the need for fluid resuscitation and is not likely to be helpful in the clinical setting. In our population, nearly 50% had no second i.v. This preliminary review of the nature of pediatric trauma suggests that ATLS guidelines may not always be appropriate for the management of pediatric trauma.
Published: 2006
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15. Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation

Author: Alain Géloën, Jennifer Rieusset, Sandra Pesenti, Bader Zarrouki, Roxane E. Vella, Marie-Agnès Chauvin, Nicolas J. Pillon, Marine L. Croze, Michel Guichardant, Christophe O. Soulage, Laetitia Koppe, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Multidisciplinaire de Biochimie des Lipides (IMBL), Covalab-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)
Subjects: medicine.medical_specialty, Ozone/*toxicity, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Type 2 diabetes, Phenylbutyrates/pharmacology, Biology, medicine.disease_cause, Acetylcysteine/pharmacology, Cell Line, Bronchoalveolar Lavage Fluid/chemistry, Mice, Ozone, Insulin resistance, Internal medicine, 11. Sustainability, Internal Medicine, medicine, Animals, JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Anthracenes, Insulin, c-jun, JNK Mitogen-Activated Protein Kinases, Skeletal muscle, medicine.disease, Phenylbutyrates, Acetylcysteine, 3. Good health, Rats, Enzyme Activation, Anthracenes/pharmacology, Insulin receptor, Endocrinology, medicine.anatomical_structure, 13. Climate action, Insulin Resistance/*physiology, Unfolded protein response, biology.protein, Enzyme Activation/drug effects, Insulin Resistance, Bronchoalveolar Lavage Fluid, Oxidative stress
Abstract: International audience; A growing body of evidence suggests that exposure to traffic-related air pollution is a risk factor for type 2 diabetes. Ozone, a major photochemical pollutant in urban areas, is negatively associated with fasting glucose and insulin levels, but most aspects of this association remain to be elucidated. Using an environmentally realistic concentration (0.8 parts per million), we demonstrated that exposure of rats to ozone induced whole-body insulin resistance and oxidative stress, with associated endoplasmic reticulum (ER) stress, c-Jun N-terminal kinase (JNK) activation, and disruption of insulin signaling in skeletal muscle. Bronchoalveolar lavage fluids from ozone-treated rats reproduced this effect in C2C12 myotubes, suggesting that toxic lung mediators were responsible for the phenotype. Pretreatment with the chemical chaperone 4-phenylbutyric acid, the JNK inhibitor SP600125, or the antioxidant N-acetylcysteine alleviated insulin resistance, demonstrating that ozone sequentially triggered oxidative stress, ER stress, and JNK activation to impair insulin signaling in muscle. This study is the first to report that ozone plays a causative role in the development of insulin resistance, suggesting that it could boost the development of diabetes. We therefore provide a potential mechanism linking pollutant exposure and the increased incidence of metabolic diseases.
Published: 2015
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16. COLONIZZAZIONE BIOLOGICA NEL CHIOSTRO GRANDE DELLA CERTOSA DEL GALLUZZO (FIRENZE) E PROPOSTA DI INTERVENTO IN SITU

Author: O.A Cuzman, E. Vella, S. Ventura, C. Faraloni, K. Sterflinger, J. Ettenauer, C. Riminesi, and P. Tiano
Subjects: controllo, colonizazzione biologica
Abstract: I monumenti di pietra situati all'esterno sono soprattutto colonizzati da organismi fototrofi come cianobatteri e alghe verdi (Tiano et al, 1995), funghi neri meristematici (Sterflinger, 2005) e licheni, con particolare rilevanza di quelli incrostanti (Nascimbene et al, 2009). Oltre la modifica dell'aspetto estetico, questi organismi svolgono un ruolo importante nei processi di degrado dei manufatti in pietra. Per controllare la crescita biologica indesiderata è molto comune l'uso dei prodotti chimici, in particolare dei biocidi, che a causa della loro tossicità possono avere effetti indesiderati sull'ambiente. Questo lavoro è stato dedicato allo studio della biodiversità in un ambiente esterno - Chiostro Grande della Certosa del Galluzzo, Firenze, prima e dopo l'applicazione in situ di un metodo innovativo per il controllo della crescita biologica, basato sul riscaldamento a microonde. Questa metodologia è stata sperimentalmente applicata su 2 tipi di colonizzazione biologica su marmo: (i) patine nere dovute alla crescita di funghi neri e cianobatteri, e (ii) croste dovute alla presenza di licheni. Le caratteristiche morfologiche degli organismi sono state analizzate tramite microscopia ottica. Misure di fluorescenza della clorofilla, con fluorimetro PAM, sono state utilizzate per valutare l'attività fotosintetica prima e dopo il trattamento, mentre le tecniche molecolari ARISA e clonaggio sono state impiegate per lo studio della comunità microbica, sia per valutare l'effetto del trattamento, sia per analizzare il processo di ricolonizzazione. Il trattamento localizzato a microonde è a basso impatto per il substrato e per l'ambiente in quanto il volume riscaldato si estende fino ad una profondità massima di 1 cm e la temperatura, controllata automaticamente durante il trattamento, non supera i 65 °C. La tecnica si candida quindi come una potenziale alternativa per il controllo della crescita biologica ai trattamenti biocidi classici.
Published: 2015

17. Direct Measurement ofAbandAcat theZ0Pole Using a Lepton Tag

Author: Kenji Abe, Koya Abe, T. Abe, I. Adam, T. Akagi, N. J. Allen, A. Arodzero, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, J. M. Bauer, G. Bellodi, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, R. M. Byrne, A. Calcaterra, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, M. R. Convery, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, C. J. S. Damerell, M. N. Danielson, M. Daoudi, N. de Groot, R. Dell'Orso, P. J. Dervan, R. de Sangro, M. Dima, A. D'Oliveira, D. N. Dong, M. Doser, R. Dubois, B. I. Eisenstein, V. Eschenburg, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, K. Flood, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. R. Goodman, E. L. Hart, J. L. Harton, A. Hasan, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, X. Huynh, H. Hwang, M. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, Y. Kamyshkov, H. J. Kang, I. Karliner, H. Kawahara, Y. D. Kim, R. King, M. E. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, M. Langston, A. Lath, D. W. G. Leith, V. Lia, C.-J. S. Lin, X. Liu, M. X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, M. Mahjouri, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, G. Menegatti, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, M. Morii, D. Muller, V. Murzin, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, H. Park, C. H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, A. Stahl, P. Stamer, R. Steiner, H. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, J. Thom, E. Torrence, N. K. Toumbas, T. Usher, C. Vannini, J. Va'vra, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, D. L. Wagner, A. P. Waite, S. Walston, J. Wang, C. Ward, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, B. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, J. L. Wittlin, M. Woods, G. B. Word, T. R. Wright, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Coupling, Physics, Semileptonic decay, Particle physics, Muon, Hadron, Detector, General Physics and Astronomy, High Energy Physics::Experiment, Parity (physics), Electron, Nuclear Experiment, Lepton
Abstract: The parity violation parameters Ab and Ac of the Zb anti-b and Zc anti-c couplings have been measured directly, using the polar angle dependence of the Z0-pole polarized cross sections. Bottom and charmed hadrons were tagged via semileptonic decays. Both the muon and electron identification algorithms take advantage of new multivariate techniques, incorporating for the first time information from the SLD Cerenkov Ring Imaging Detector. Based on the 1993-95 SLD sample of 150,000 Z0 decays produced with highly polarized electron beams, we measure: Ab = 0.910 ± 0.068(stat) ± 0.037(syst) Ac = 0.642 ± 0.110(stat) ± 0.063(syst).
Published: 1999
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18. Direct Measurement ofAbinZ0Decays Using Charged Kaon Tagging

Author: Kenji Abe, Koya Abe, T. Abe, I. Adam, T. Akagi, N. J. Allen, A. Arodzero, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, J. M. Bauer, G. Bellodi, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, R. M. Byrne, A. Calcaterra, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, M. R. Convery, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, C. J. S. Damerell, M. N. Danielson, M. Daoudi, N. de Groot, R. Dell'Orso, P. J. Dervan, R. de Sangro, M. Dima, A. D'Oliveira, D. N. Dong, M. Doser, R. Dubois, B. I. Eisenstein, V. Eschenburg, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, K. Flood, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. R. Goodman, E. L. Hart, J. L. Harton, A. Hasan, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, X. Huynh, H. Hwang, M. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, Y. Kamyshkov, H. J. Kang, I. Karliner, H. Kawahara, Y. D. Kim, R. King, M. E. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, M. Langston, A. Lath, D. W. G. Leith, V. Lia, C.-J. S. Lin, X. Liu, M. X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, M. Mahjouri, G. Mancinelli, S. Manley, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, G. Menegatti, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, M. Morii, D. Muller, V. Murzin, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, H. Park, C. H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, A. Stahl, P. Stamer, R. Steiner, H. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, J. Thom, E. Torrence, N. K. Toumbas, T. Usher, C. Vannini, J. Va'vra, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, D. L. Wagner, A. P. Waite, S. Walston, J. Wang, C. Ward, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, B. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, J. L. Wittlin, M. Woods, G. B. Word, T. R. Wright, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Nuclear physics, Quark, Physics, Particle physics, media_common.quotation_subject, Hadron, General Physics and Astronomy, Electron, Asymmetry, Vertex (geometry), media_common, Boson
Abstract: We present a direct measurement of the parity-violating asymmetry A{sub b} in the Z{sup 0} to b anti-b coupling using a new technique to distinguish the b and anti-b quarks using charged kaons from B decays. The Z{sup 0} bosons are produced in e{sup +}e{sup -} collisions at the SLC with longitudinally polarized electrons. b anti-b events are selected using a secondary vertex mass tag and A{sub b} is determined from the left-right forward-backward asymmetry. From the 1994-1995 data sample, selected from 100,000 hadronic Z{sup 0} decays, we obtain A{sub b} = 0.855 {+-} 0. 088{sub stat} {+-} 0.102{sub sys}.
Published: 1999
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19. Direct Measurement of Parity Violation in the Coupling ofZ0Bosons tobQuarks Using a Mass Tag and Momentum-Weighted Track Charge

Author: K. Abe, T. Abe, I. Adam, T. Akagi, N. J. Allen, A. Arodzero, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, O. Bardon, T. L. Barklow, J. M. Bauer, G. Bellodi, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, M. R. Convery, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, C. J. S. Damerell, M. N. Danielson, M. Daoudi, N. de Groot, R. Dell'Orso, P. J. Dervan, R. de Sangro, M. Dima, A. D'Oliveira, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, V. Eschenburg, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, K. Flood, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. L. Hart, J. L. Harton, A. Hasan, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, X. Huynh, H. Hwang, M. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, Y. Kamyshkov, H. J. Kang, I. Karliner, H. Kawahara, Y. D. Kim, R. King, M. E. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, M. Langston, A. Lath, D. W. G. Leith, V. Lia, C.-J. S. Lin, X. Liu, M. X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, G. Menegatti, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, M. Morii, D. Muller, V. Murzin, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, H. Park, C. H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, A. Stahl, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, J. Thom, E. Torrence, N. K. Toumbas, A. I. Trandafir, J. D. Turk, T. Usher, C. Vannini, J. Va'vra, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, D. L. Wagner, A. P. Waite, S. Walston, J. Wang, C. Ward, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, B. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, J. L. Wittlin, M. Woods, G. B. Word, T. R. Wright, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Physics, Quark, Meson, High Energy Physics::Phenomenology, Hadron, General Physics and Astronomy, Elementary particle, Parity (physics), Nuclear physics, Particle decay, Physics::Accelerator Physics, High Energy Physics::Experiment, B meson, Boson
Abstract: We present a direct measurement of the parity-violation parameter ${A}_{b}$ using a self-calibrating track-charge technique. In the SLAC Linear Collider Large Detector (SLD) experiment we observe hadronic decays of ${Z}^{0}$ bosons produced in collisions between longitudinally polarized electrons and unpolarized positrons at the SLAC Linear Collider. A sample of $b\overline{b}$ events is selected using the topologically reconstructed mass of $B$ hadrons. From our 1993--1995 sample of approximately 150 000 hadronic ${Z}^{0}$ decays, we obtain ${A}_{b}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.911\ifmmode\pm\else\textpm\fi{}0.045(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}0.045(\mathrm{syst})$.
Published: 1998
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20. Measurement of Rb Using a Vertex Mass Tag

Author: K. Abe, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, N. de Groot, R. De Sangro, R. Dell'Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, R. Frey, T. Gillman, G. Gladding, S. Gonzalez, E. L. Hart, J. L. Harton, A. Hasan, Y. Hasegawa, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, Z. Y. Jiang, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. D. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, N. Oishi, D. Onoprienko, L. S. Osborne, R. S. Panvini, C. H. Park, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, H. Staengle, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, D. L. Wagner, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, J. Zhou, Abe, K, Akagi, T, Allen, N, Ash, W, Aston, D, Baird, K, Baltay, C, Band, H, Barakat, M, Baranko, G, Bardon, O, Barklow, T, Bashindzhagyan, G, Bazarko, A, Ben David, R, Benvenuti, A, Bilei, G, Bisello, D, Blaylock, G, Bogart, J, Bolen, B, Bolton, T, Bower, G, Brau, J, Breidenbach, M, Bugg, W, Burke, D, Burnett, T, Burrows, P, Busza, W, Calcaterra, A, Caldwell, D, Calloway, D, Camanzi, B, Carpinelli, M, Cassell, R, Castaldi, R, Castro, A, Cavalli Sforza, M, Chou, A, Church, E, Cohn, H, Coller, J, Cook, V, Cotton, R, Cowan, R, Coyne, D, Crawford, G, D'Oliveira, A, Damerell, C, Daoudi, M, de Groot, N, De Sangro, R, Dell'Orso, R, Dervan, P, Dima, M, Dong, D, Du, P, Dubois, R, Eisenstein, B, Elia, R, Etzion, E, Fahey, S, Falciai, D, Fan, C, Fernandez, J, Faro, M, Frey, R, Gillman, T, Gladding, G, Gonzalez, S, Hart, E, Harton, J, Hasan, A, Hasegawa, Y, Hasuko, K, Hedges, S, Hertzbach, S, Hildreth, M, Huber, J, Huffer, M, Hughes, E, Hwang, H, Iwasaki, Y, Jackson, D, Jacques, P, Jaros, J, Jiang, Z, Johnson, A, Johnson, J, Johnson, R, Junk, T, Kajikawa, R, Kalelkar, M, Kang, H, Karliner, I, Kawahara, H, Kendall, H, Kim, Y, King, M, King, R, Kofler, R, Krishna, N, Kroeger, R, Labs, J, Langston, M, Lath, A, Lauber, J, Leith, D, Lia, V, Liu, M, Liu, X, Loreti, M, Lu, A, Lynch, H, Ma, J, Mancinelli, G, Manly, S, Mantovani, G, Markiewicz, T, Maruyama, T, Masuda, H, Mazzucato, E, Mckemey, A, Meadows, B, Messner, R, Mockett, P, Moffeit, K, Moore, T, Muller, D, Nagamine, T, Narita, S, Nauenberg, U, Neal, H, Nussbaum, M, Ohnishi, Y, Oishi, N, Onoprienko, D, Osborne, L, Panvini, R, Park, C, Park, H, Pavel, T, Peruzzi, I, Piccolo, M, Piemontese, L, Pieroni, E, Pitts, K, Plano, R, Prepost, R, Prescott, C, Punkar, G, Quigley, J, Ratcliff, B, Reeves, T, Reidy, J, Reinertsen, P, Rensing, P, Rochester, L, Rowson, P, Russell, J, Saxton, O, Schall, T, Schindler, R, Schumm, B, Schwiening, J, Sen, S, Serbo, V, Shaevitz, M, Shank, J, Shapiro, G, Sherden, D, Shmakov, K, Simopoulos, C, Sinev, N, Smith, S, Smy, M, Snyder, J, Staengle, H, Stamer, P, Steiner, H, Steiner, R, Strauss, M, Su, D, Suekane, F, Sugiyama, A, Suzuki, S, Swartz, M, Szumilo, A, Takahashi, T, Taylor, F, Torrence, E, Trandafir, A, Turk, J, Usher, T, Va'Vra, J, Vannini, C, Vella, E, Venuti, J, Verdier, R, Verdini, P, Wagner, D, Wagner, S, Waite, A, Watts, S, Weidemann, A, Weiss, E, Whitaker, J, White, S, Wickens, F, Williams, D, Williams, S, Willocq, S, Wilson, R, Wisniewski, W, Woods, M, Word, G, Wyss, J, Yamamoto, R, Yamartino, J, Yang, X, Yashima, J, Yellin, S, Young, C, Yuta, H, Zapalac, G, Zdarko, R, and Zhou, J
Subjects: Physics, Particle physics, Meson, Physics::Instrumentation and Detectors, Electron–positron annihilation, Gluons, Hadron, FOS: Physical sciences, General Physics and Astronomy, Elementary particle, High Energy Physics - Experiment, Vertex (geometry), High Energy Physics - Experiment (hep-ex), Particle decay, B meson, High Energy Physics::Experiment, Nuclear Experiment, Boson
Abstract: We report a new measurement of Rb = Gamma(Z0->b-bbar) / Gamma(Z0->hadrons) using a double tag technique, where the b hemisphere selection is based on the reconstructed mass of the B hadron decay vertex. The measurement was performed using a sample of 130k hadronic Z0 events, collected with the SLD at the SLC. The method utilizes the 3-D vertexing abilities of the CCD pixel vertex detector and the small stable SLC beams to obtain a high b-tagging efficiency and purity. We obtain Rb=0.2142+/-0.0034(stat.)+/-0.0015(syst.)+/-0.0002(R_c)., 11 pages including 3 eps files
Published: 1998

21. Measurement of theBhadron energy distribution inZ0decays

Author: C. Fan, K.D. Shmakov, T.J. Pavel, R. Frey, A. P. Waite, T. Bolton, H. Staengle, Yukio Hasegawa, J. R. Johnson, R. Kajikawa, D. G. Coyne, Robert Wilson, J. A. Coller, Gilbert Shapiro, R. Verdier, T. Akagi, L. Piemontese, T. Nagamine, B. I. Einsenstein, X. Liu, S. S. Hertzbach, Henry W. Kendall, X. Yang, D. C. Williams, C. Baltay, H. Masuda, E. L. Hart, D. Aston, T. B. Moore, Enrico Pieroni, J. F. Labs, B. Bolen, D. Onoprienko, J. Schwiening, T. Schalk, V. Cook, D. Calloway, A. I. Trandafir, E. Mazzucato, A. Hasan, Michael H. Shaevitz, H. M. Steiner, Piero Giorgio Verdini, R. de Sangro, G. Mancinelli, Wit Busza, Roberto Dell'Orso, K. Hasuko, C. Vannini, J. D. Turk, R. E. Cassell, Martin Breidenbach, P.E. Rensing, M. Dima, B. Camanzi, Giancarlo Mantovani, R. Prepost, E. Church, H. Hwang, T. Junk, J. L. Harton, M. Loreti, J. Va'vra, J. J. Russell, E. Etzion, L.S. Osborne, J. Quigley, T. Takahashi, T. H. Burnett, C. Y. Prescott, P.Y.C. Du, J.J. Reidy, R. S. Panvini, D. Falciai, R. Messner, Stephen Robert Wagner, R. Dubois, J. S. Whitaker, R. A. Johnson, Stephen Watts, R. Cowan, D. Su, E. Vella, G. Baranko, A. S. Johnson, J. Wyss, Shiro Suzuki, S. L. White, M. Daoudi, N. Oishi, M. D. Hildreth, A. Chou, K.C. Moffeit, G. B. Word, P.L. Reinertsen, J.P. Venuti, C.J.S. Damerell, M. Piccolo, R.J. Plano, J. M. Yamartino, D. J. Sherden, W. J. Wisniewski, A.C. Benvenuti, N. B. Sinev, A. Sugiyama, M. Carpinelli, S. J. Yellin, S. Sen, C. H. Park, Bruce Schumm, N.M. Krishna, H. A. Neal, Yongduk Kim, M. Kalelkar, H. Kawahara, S. R. Smith, A.B. d'Oliveira, F. E. Taylor, G. Crawford, M.B. Barakat, R.D. Elia, S. Willocq, G. E. Gladding, Zihao Jiang, J. R. Bogart, A. Lu, R. K. Yamamoto, Rino Castaldi, H. O. Cohn, R. Ben-David, D. W. G. S. Leith, P.F. Jacques, J. Zhou, T. Gillman, V. V. Serbo, G. Blaylock, A. Calcaterra, S. Manly, P. C. Rowson, G. D. Punkar, N. De Groot, S. J. Hedges, W. W. Ash, R. Cotton, E. Torrence, H. J. Kang, M. Nussbaum, Minghui Liu, R. Steiner, Michael J. Fero, E. R. Weiss, R. W. Zdarko, S. Gonzalez, F. Suekane, J. A. Snyder, M.E. King, H. Yuta, M. Cavalli-Sforza, M. Langston, B. T. Meadows, K. T. Pitts, J. E. Brau, N.J. Allen, A. Lath, T. W. Reeves, O. Bardon, B. N. Ratcliff, E. W. Hughes, C. Simopoulos, K.G. Baird, S. H. Williams, A. K. McKemey, P. E. Stamer, D. O. Caldwell, Timothy Barklow, Thomas W. Markiewicz, M. E. Huffer, C. C. Young, D. J. Jackson, J. Yashima, S. Fahey, M. B. Smy, J. Ma, L. S. Rochester, G. M. Bilei, G. R. Bower, M. Swartz, James Shank, Andrea Castro, Y. Iwasaki, T. L. Usher, H. Park, G. H. Zapalac, P.J. Dervan, D. L. Wagner, U. Nauenberg, S. Narita, R. King, P. N. Burrows, Dario Bisello, Y. Ohnishi, O. H. Saxton, H. R. Band, Fred Wickens, T. Maruyama, K. Abe, M. Woods, R. R. Kofler, G. L. Bashindzhagyan, J. A. Lauber, H. L. Lynch, A. W. Weidemann, J. A. Jaros, P. M. Mockett, J. Huber, I. Karliner, M. G. Strauss, Dominik Müller, D. N. Dong, R. H. Schindler, A. Szumilo, R. Kroeger, I. M. Peruzzi, V. Lia, D. L. Burke, W. M. Bugg, A. O. Bazarko, and J. P. Fernandez
Subjects: Physics, Quark, Nuclear and High Energy Physics, Particle physics, Energy distribution, 010308 nuclear & particles physics, Electron–positron annihilation, High Energy Physics::Phenomenology, Hadron, 7. Clean energy, 01 natural sciences, Vertex (geometry), Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Lepton
Abstract: We have measured the $B$ hadron energy distribution in ${Z}^{0}$ decays using a sample of semileptonic $B$ decays recorded in the SLD experiment at SLAC. The energy of each tagged $B$ hadron was reconstructed using information from the lepton and a partially reconstructed charm-decay vertex. We compared the scaled energy distribution with several models of heavy quark fragmentation. The average scaled energy of primary $B$ hadrons was found to be $〈{x}_{{E}_{B}}〉=0.716\ifmmode\pm\else\textpm\fi{}0.011(\mathrm{stat}{)}_{\ensuremath{-}0.022}^{+0.021}(\mathrm{syst})$.
Published: 1997
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22. Measurement of theτNeutrino Helicity and Michel Parameters in Polarizede+e−Collisions

Author: K. Abe, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, R. Dell'Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, S. Fahey, D. Falciai, C. Fan, J. P. Fernandez, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, E. L. Hart, J. L. Harton, A. Hasan, Y. Hasegawa, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. D. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, C. H. Park, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, D. L. Wagner, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, J. Yashima, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Physics, Particle physics, Electron–positron annihilation, General Physics and Astronomy, Elementary particle, Astrophysics::Cosmology and Extragalactic Astrophysics, Helicity, Nuclear physics, Particle decay, Tau neutrino, mental disorders, Michel parameters, High Energy Physics::Experiment, Astrophysics::Earth and Planetary Astrophysics, Neutrino, Lepton
Abstract: We present a new measurement of the tau neutrino helicity, hnu and the tau Michel parameters rho, eta, xi and the product delta xi. The analysis exploits the highly polarized SLC electron beam to extract these quantities directly from a measurement of the tau decay spectra, using the 1993-1995 SLD data sample of 4328 e+e- --> Z0 --> tau+tau- events. From the decays tau --> pi nu(tau) and tau --> rho nu(tau) we obtain a combined value hnu=-0.93+/-0.10+/-0.04. The leptonic decay channels yield combined values of rho=0.72+/-0.09+/-0.03, xi=1.05+/-0.35+/-0.04 and delta xi=0.88+/-0.27+/-0.04.
Published: 1997
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23. Measurement of Leading Particle Effects in Decays ofZ0Bosons into Light Flavors

Author: T. W. Reeves, A. Chou, K.C. Moffeit, R. Dubois, S. R. Smith, H. A. Neal, S. Fahey, P.L. Reinertsen, A. Sugiyama, J. M. Yamartino, C. Y. Prescott, L. S. Rochester, Stephen Watts, R. R. Kofler, J. Quigley, J. Wyss, Michael J. Fero, E. R. Weiss, C. H. Park, Bruce Schumm, D. Su, T. Bolton, M. Dima, Stephen Robert Wagner, B. N. Ratcliff, A. Lu, C. Simopoulos, M. Cavalli-Sforza, B. T. Meadows, P. E. Stamer, M.B. Barakat, M. E. Huffer, C. C. Young, J. Yashima, J. D. Turk, V. V. Serbo, N.J. Allen, R.D. Elia, G. E. Gladding, J. Schwiening, A. I. Trandafir, M. Piccolo, Gilbert Shapiro, R. E. Cassell, P.E. Rensing, R. H. Schindler, R. Verdier, E. L. Hart, T. Nagamine, M. Kalelkar, T. Schalk, G. L. Bashindzhagyan, C. Vannini, E. Etzion, A. Hasan, M. Carpinelli, Michael H. Shaevitz, A. Szumilo, M. Loreti, B. Bolen, T. H. Burnett, W. J. Wisniewski, M. Langston, J. A. Coller, S. Manly, O. Bardon, F. E. Taylor, J. R. Bogart, D. Aston, S. J. Yellin, A. Calcaterra, K. Hasuko, R. Prepost, P.F. Jacques, R. Kroeger, D. Calloway, S. Sen, G. H. Zapalac, R. K. Yamamoto, N.M. Krishna, A. P. Waite, X. Yang, D. C. Williams, S. J. Hedges, O. H. Saxton, M. Nussbaum, R. Cowan, K. T. Pitts, Shiro Suzuki, Timothy Barklow, Piero Giorgio Verdini, X. Liu, S. S. Hertzbach, R. W. Zdarko, M.E. King, J. J. Russell, S. Willocq, A. S. Johnson, R. Steiner, H. R. Band, L.S. Osborne, Rino Castaldi, H. O. Cohn, K. Furuno, Giancarlo Mantovani, W. W. Ash, R. Messner, S. Gonzalez, M. D. Hildreth, V. Cook, K.D. Shmakov, Yukio Hasegawa, H. Hwang, H. L. Lynch, J. S. Whitaker, Alberto Benvenuti, R. Ben-David, G. D. Punkar, R. de Sangro, E. Vella, R. A. Johnson, J. E. Brau, A. W. Weidemann, J. Zhou, H. Kawahara, G. B. Word, D. G. Coyne, Henry W. Kendall, D. J. Sherden, C. Fan, J.P. Venuti, D. J. Jackson, Fred Wickens, D. W. G. S. Leith, C.J.S. Damerell, R. J. Wilson, A. O. Bazarko, Martin Breidenbach, R. Cotton, Yongduk Kim, C. Baltay, E. W. Hughes, J. A. Lauber, H. Masuda, S. H. Williams, J. Ma, Minghui Liu, D. Onoprienko, G. Blaylock, B. Camanzi, G. M. Bilei, G. R. Bower, R. S. Panvini, D. Falciai, G. Crawford, M. Swartz, James Shank, Andrea Castro, Wit Busza, F. Suekane, P. C. Rowson, J. A. Jaros, P.J. Dervan, H. Yuta, D. O. Caldwell, Thomas W. Markiewicz, T. Gillman, E. Church, T. Junk, J. L. Harton, S. Narita, Tadayuki Takahashi, J. P. Fernandez, P. M. Mockett, G. Baranko, M. B. Smy, Y. Iwasaki, K.G. Baird, David A. Williams, J. Huber, T. L. Usher, S. L. White, A. K. McKemey, R. King, R.J. Plano, I. Karliner, M. G. Strauss, Dominik Müller, H. Park, T. Maruyama, Y. Ohnishi, B. I. Eisenstein, D. N. Dong, J. A. Snyder, A. Lath, I. M. Peruzzi, E. Mazzucato, A.B. d'Oliveira, E. Torrence, H. J. Kang, Roberto Dell'Orso, J. Va'vra, J.J. Reidy, N. B. Sinev, D. L. Wagner, V. Lia, U. Nauenberg, D. L. Burke, W. M. Bugg, P. N. Burrows, Dario Bisello, T.J. Pavel, R. Frey, J. R. Johnson, R. Kajikawa, H. M. Steiner, T. Akagi, L. Piemontese, T. B. Moore, Enrico Pieroni, J. F. Labs, G. Mancinelli, P.Y.C. Du, M. Daoudi, K. Abe, and M. Woods
Subjects: Quark, Physics, Antiparticle, Particle physics, Meson, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Lattice, High Energy Physics::Phenomenology, Hadron, General Physics and Astronomy, Elementary particle, Quarkonium, Nuclear physics, Particle decay, High Energy Physics::Experiment, Boson
Abstract: We present evidence for leading particle production in hadronic decays of the Z{sup 0} boson to light-flavor jets. A polarized electron beam was used to tag quark and antiquark jets, and a vertex detector was employed to reject heavy-flavor events. Charged hadrons were identified with a Cherenkov ring imaging detector. In the quark jets, more high-momentum p, L, K{sup -}, and {bar K}{sup *0} were observed than their antiparticles, and vice versa for antiquark jets, providing direct evidence that the higher-momentum particles in jets are more likely to carry the primary quark or antiquark from the Z{sup 0} decay, and that s{bar s} production is suppressed in fragmentation. {copyright} {ital 1997} {ital The American Physical Society}
Published: 1997
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24. Improved Measurement of the Left-RightZ0Cross Section Asymmetry

Author: K. Abe, I. Abt, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, R. Dell'Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, S. Fahey, D. Falciai, C. Fan, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, J. L. Harton, A. Hasan, Y. Hasegawa, K. Hasuko, S. J. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. D. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, C. H. Park, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, K. Reeves, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, J. Schwiening, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, D. L. Wagner, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Physics, Particle physics, Electron–positron annihilation, media_common.quotation_subject, General Physics and Astronomy, Weinberg angle, Elementary particle, Polarization (waves), Asymmetry, Linear particle accelerator, Nuclear physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment, media_common, Boson
Abstract: We present a new measurement of the left-right cross section asymmetry (ALR) for Z boson production by e+e- collisions. The measurement was performed at a center-of-mass energy of 91.28 GeV with the SLD detector at the SLAC Linear Collider (SLC). The luminosity-weighted average polarization of the SLC electron beam was (77.23+-0.52)%. Using a sample of 93,644 Z decays, we measure the pole-value of the asymmetry, ALR0, to be 0.1512+-0.0042(stat.)+-0.0011(syst.) which is equivalent to an effective weak mixing angle of sin**2(theta_eff)=0.23100+-0.00054(stat.)+-0.00014(syst.).
Published: 1997
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25. Study of the orientation and energy partition of three-jet events in hadronic Z0 decays

Author: K. Abe, I. Abt, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D’Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, P. De Simone, R. Dell’Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, D. Falciai, C. Fan, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, A. Hasan, Y. Hasegawa, K. Hasuko, S. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, R. Massetti, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, B. Mours, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. E. Rensing, T. G. Rizzo, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va’vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, C. Zeitlin, and J. Zhou
Subjects: Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, Meson, High Energy Physics::Lattice, Computer Science::Information Retrieval, High Energy Physics::Phenomenology, Hadron, Scalar (mathematics), Perturbative QCD, Elementary particle, Gluon, Nuclear physics, Particle decay, High Energy Physics::Experiment
Abstract: We have measured the distributions of the jet energies in {ital e{sup +}e{sup {minus}}{r_arrow}q{bar q}g} events, and of the three orientation angles of the event plane, using hadronic {ital Z{sup 0}} decays collected in the SLD experiment at SLAC. We find that the data are well described by perturbative QCD incorporating vector gluons. We have also studied models of scalar and tensor gluon production and find them to be incompatible with our data. {copyright} {ital 1997} {ital The American Physical Society}
Published: 1997

26. First Measurement of the Left-Right Charge Asymmetry in HadronicZBoson Decays and a New Determination ofsin2θWeff

Author: K. Abe, I. Abt, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. L. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, B. Bolen, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, R. Dell'Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, S. Fahey, D. Falciai, C. Fan, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, J. L. Harton, A. Hasan, Y. Hasegawa, K. Hasuko, S. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. A. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. D. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, T. B. Moore, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, C. H. Park, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. L. Reinertsen, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, M. B. Smy, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, D. L. Wagner, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, and J. Zhou
Subjects: Physics, Particle physics, Particle decay, Electron–positron annihilation, media_common.quotation_subject, Hadron, General Physics and Astronomy, Weinberg angle, Elementary particle, Asymmetry, Boson, media_common
Abstract: We present the first measurement of the left-right charge asymmetry ${A}_{Q}^{\mathrm{obs}}$ in hadronic $Z$ boson decays. This was performed at ${E}_{\mathrm{c}.\mathrm{m}.}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}91.27\mathrm{GeV}$ with the SLD at the SLAC Linear Collider with a polarized electron beam. Using 89 838 events we obtain ${A}_{Q}^{\mathrm{obs}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.225\ifmmode\pm\else\textpm\fi{}0.056\ifmmode\pm\else\textpm\fi{}0.019$, which leads to a measurement of the electron left-right asymmetry parameter, ${A}_{e}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.162\ifmmode\pm\else\textpm\fi{}0.041\ifmmode\pm\else\textpm\fi{}0.014$, and ${sin}^{2}{\ensuremath{\theta}}_{W}^{\mathrm{eff}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.2297\ifmmode\pm\else\textpm\fi{}0.0052\ifmmode\pm\else\textpm\fi{}0.0018$. Also, the ${A}_{Q}^{\mathrm{obs}}$ measurement combined with the left-right cross section asymmetry determines ${A}_{e}$ independent of the value of the electron-beam polarization.
Published: 1997
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27. Comorbidity in detoxification: symptom interaction and treatment intentions

Author: Frank P. Deane, Veronica E Vella, and Peter J. Kelly
Subjects: Adult, Male, medicine.medical_specialty, Substance-Related Disorders, media_common.quotation_subject, medicine.medical_treatment, Medicine (miscellaneous), Comorbidity, Detoxification (alternative medicine), Perception, medicine, Humans, Psychiatry, media_common, Mental Disorders, Patient Preference, Middle Aged, Patient Acceptance of Health Care, medicine.disease, Mental health treatment, Mental health, Psychiatry and Mental health, Clinical Psychology, Diagnosis, Dual (Psychiatry), Female, Queensland, Pshychiatric Mental Health, Substance use, Psychology, Clinical psychology
Abstract: Co-occurring substance use and mental health disorders (CODs) are common. However, very little is known about individuals' recognition of, and perception of the relationship between these disorders. The current study aimed to examine problem recognition, perceived disorder relationships, treatment intentions, and treatment preferences of individuals attending Australian detoxification facilities. Questionnaires were completed by 225 participants, including the Mental Health Screening Form III and the Treatment Preferences Questionnaire. Results indicated that 56.4% of participants screened positive for CODs, with only 4.2% failing to recognise their mental health problems. Participants perceived a functional relationship between disorders, where improvement/deterioration of one disorder leads to the improvement/deterioration of the other. Recognition of mental health problems and perception of a functional relationship between disorders, predict high mental health treatment intentions. These findings have important clinical implications when planning treatment programs and counselling individuals with CODs.
Published: 2013

28. White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease

Author: Alain Géloën, Roxane E. Vella, Lionel Badet, Emilie Kalbacher, Christophe O. Soulage, Fitsum Guebre-Egziabher, Marine L. Croze, Caroline C. Pelletier, Laetitia Koppe, Denis Fouque, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), and Vericel, Evelyne
Subjects: Male, Biopsy, 030232 urology & nephrology, Adipose tissue, White adipose tissue, Mice, 0302 clinical medicine, Aged, 80 and over, 0303 health sciences, medicine.diagnostic_test, Middle Aged, Up-Regulation, 3. Good health, Nephrology, Lipogenesis, Female, zinc α2-glycoprotein, Peritoneal Dialysis, Adult, medicine.medical_specialty, Adipose Tissue, White, Adipokine, Biology, Article, 03 medical and health sciences, Adipokines, white adipose tissue, Renal Dialysis, 3T3-L1 Cells, Internal medicine, medicine, Animals, Humans, Lipolysis, Rats, Wistar, Renal Insufficiency, Chronic, lipogenesis, Aged, Glycoproteins, Uremia, 030304 developmental biology, medicine.disease, Rats, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Disease Models, Animal, Endocrinology, ZAG, Case-Control Studies, lipolysis, Kidney Failure, Chronic, Carrier Proteins, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, chronic kidney disease, Kidney disease
Abstract: Chronic kidney disease (CKD) is frequently associated with protein energy wasting which has been recognized as a strong predictive factor of mortality. Zinc α2-glycoprotein (ZAG) has been proposed as a new adipokine involved in body weight control through its lipid mobilizing activity. We hypothesized that the uremic environment in CKD could alter ZAG production by white adipose tissue and contribute to CKD-associated metabolic disturbances. ZAG protein was quantified in 3T3-L1 adipocytes after incubation with plasma from healthy volunteers and CKD patients (20%, v/v). ZAG was also measured in white adipose tissue (WAT) from 5/6 nephrectomized rodents (Nx5/6) and subcutaneous adipose tissue biopsies from end-stage renal disease patients. Uremic plasma induced a significant increase in ZAG synthesis in 3T3-L1 adipocytes (+124%, p
Published: 2013
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29. First Study of Rapidity Gaps ine+e−Annihilation

Author: K. Abe, I. Abt, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. Barklow, G. L. Bashindzhagyan, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, A. Chou, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, G. Crawford, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, P. De Simone, R. Dell'Orso, P. J. Dervan, M. Dima, D. N. Dong, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, E. Etzion, D. Falciai, C. Fan, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, A. Hasan, Y. Hasegawa, K. Hasuko, S. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. S. Leith, V. Lia, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, R. Massetti, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, B. Mours, D. Muller, T. Nagamine, S. Narita, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. E. Rensing, L. S. Rochester, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, B. A. Schumm, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, A. I. Trandafir, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, C. Zeitlin, and J. Zhou
Subjects: Physics, Particle physics, Annihilation, Electron–positron annihilation, General Physics and Astronomy, Rapidity, Humanities
Abstract: K. Abe,20 K. Abe,30 I. Abt,14 T. Akagi,28 N. J. Allen,4 W. W. Ash,28,* D. Aston,28 K. G. Baird,25 C. Baltay,34 H. R. Band,33 M. B. Barakat,34 G. Baranko,10 O. Bardon,16 T. Barklow,28 G. L. Bashindzhagyan,19 A. O. Bazarko,11 R. Ben-David,34 A. C. Benvenuti,2 G. M. Bilei,23 D. Bisello,22 G. Blaylock,7 J. R. Bogart,28 T. Bolton,11 G. R. Bower,28 J. E. Brau,21 M. Breidenbach,28 W. M. Bugg,29 D. Burke,28 T. H. Burnett,32 P. N. Burrows,16 W. Busza,16 A. Calcaterra,13 D. O. Caldwell,6 D. Calloway,28 B. Camanzi,12 M. Carpinelli,24 R. Cassell,28 R. Castaldi,24,† A. Castro,22 M. Cavalli-Sforza,7 A. Chou,28 E. Church,32 H. O. Cohn,29 J. A. Coller,3 V. Cook,32 R. Cotton,4 R. F. Cowan,16 D. G. Coyne,7 G. Crawford,28 A. D’Oliveira,8 C. J. S. Damerell,26 M. Daoudi,28 R. De Sangro,13 P. De Simone,13 R. Dell’Orso,24 P. J. Dervan,4 M. Dima,9 D. N. Dong,16 P. Y. C. Du,29 R. Dubois,28 B. I. Eisenstein,14 R. Elia,28 E. Etzion,4 D. Falciai,23 C. Fan,10 M. J. Fero,16 R. Frey,21 K. Furuno,21 T. Gillman,26 G. Gladding,14 S. Gonzalez,16 G. D. Hallewell,28 E. L. Hart,29 A. Hasan,4 Y. Hasegawa,30 K. Hasuko,30 S. Hedges,3 S. S. Hertzbach,17 M. D. Hildreth,28 J. Huber,21 M. E. Huffer,28 E. W. Hughes,28 H. Hwang,21 Y. Iwasaki,30 D. J. Jackson,26 P. Jacques,25 J. Jaros,28 A. S. Johnson,3 J. R. Johnson,33 R. A. Johnson,8 T. Junk,28 R. Kajikawa,20 M. Kalelkar,25 H. J. Kang,27 I. Karliner,14 H. Kawahara,28 H. W. Kendall,16 Y. Kim,27 M. E. King,28 R. King,28 R. R. Kofler,17 N. M. Krishna,10 R. S. Kroeger,18 J. F. Labs,28 M. Langston,21 A. Lath,16 J. A. Lauber,10 D. W. G. S. Leith,28 V. Lia,16 M. X. Liu,34 X. Liu,7 M. Loreti,22 A. Lu,6 H. L. Lynch,28 J. Ma,32 G. Mancinelli,23 S. Manly,34 G. Mantovani,23 T. W. Markiewicz,28 T. Maruyama,28 R. Massetti,23 H. Masuda,28 E. Mazzucato,12 A. K. McKemey,4 B. T. Meadows,8 R. Messner,28 P. M. Mockett,32 K. C. Moffeit,28 B. Mours,28 D. Muller,28 T. Nagamine,28 S. Narita,30 U. Nauenberg,10 H. Neal,28 M. Nussbaum,8 Y. Ohnishi,20 L. S. Osborne,16 R. S. Panvini,31 H. Park,21 T. J. Pavel,28 I. Peruzzi,13,† M. Piccolo,13 L. Piemontese,12 E. Pieroni,24 K. T. Pitts,21 R. J. Plano,25 R. Prepost,33 C. Y. Prescott,28 G. D. Punkar,28 J. Quigley,16 B. N. Ratcliff,28 T. W. Reeves,31 J. Reidy,18 P. E. Rensing,28 L. S. Rochester,28 P. C. Rowson,11 J. J. Russell,28 O. H. Saxton,28 T. Schalk,7 R. H. Schindler,28 B. A. Schumm,15 S. Sen,34 V. V. Serbo,33 M. H. Shaevitz,11 J. T. Shank,3 G. Shapiro,15 D. J. Sherden,28 K. D. Shmakov,29 C. Simopoulos,28 N. B. Sinev,21 S. R. Smith,28 J. A. Snyder,34 P. Stamer,25 H. Steiner,15 R. Steiner,1 M. G. Strauss,17 D. Su,28 F. Suekane,30 A. Sugiyama,20 S. Suzuki,20 M. Swartz,28 A. Szumilo,32 T. Takahashi,28 F. E. Taylor,16 E. Torrence,16 A. I. Trandafir,17 J. D. Turk,34 T. Usher,28 J. Va’vra,28 C. Vannini,24 E. Vella,28 J. P. Venuti,31 R. Verdier,16 P. G. Verdini,24 S. R. Wagner,28 A. P. Waite,28 S. J. Watts,4 A. W. Weidemann,29 E. R. Weiss,32 J. S. Whitaker,3 S. L. White,29 F. J. Wickens,26 D. A. Williams,7 D. C. Williams,16 S. H. Williams,28 S. Willocq,34 R. J. Wilson,9 W. J. Wisniewski,28 M. Woods,28 G. B. Word,25 J. Wyss,22 R. K. Yamamoto,16 J. M. Yamartino,16 X. Yang,21 S. J. Yellin,6 C. C. Young,28 H. Yuta,30 G. Zapalac,33 R. W. Zdarko,28 C. Zeitlin,21 and J. Zhou21
Published: 1996
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30. Measurements ofRbwith impact parameters and displaced vertices

Author: J. M. Yamartino, Elliot Hughes, G. Mancinelli, J. E. Brau, G. M. Bilei, G. R. Bower, James Shank, S. H. Williams, Andrea Castro, E. Church, T. Junk, O. H. Saxton, H. R. Band, P. De Simone, A. P. Waite, T. Bolton, C. Y. Prescott, J.P. Venuti, R.D. Elia, M. Carpinelli, A. Calcaterra, E. Torrence, C.J.S. Damerell, R. J. Wilson, A. S. Johnson, M. Loreti, John Scott Whitaker, G. E. Gladding, A. O. Bazarko, Y.D. Kim, R. Steiner, T. Akagi, S. Gonzalez, Gilbert Shapiro, C. J. Ahn, J. Huber, G. H. Zapalac, D. Su, R. Verdier, M. Nussbaum, S. Willocq, Fred Wickens, E. L. Hart, C. Baltay, L. Piemontese, R.J. Plano, H. Masuda, J. Wyss, M. Dima, H. M. Steiner, M. Piccolo, P. M. Mockett, G. Baranko, M. Langston, B. N. Ratcliff, Thomas W. Markiewicz, Enrico Pieroni, A. Lu, E. Etzion, S. Smith, S. F. Schaffner, C. Zeitlin, C. Simopoulos, O. Bardon, P. E. Stamer, B. A. Schumm, J. F. Labs, K.G. Baird, S. Hedges, David A. Williams, Timothy Barklow, A. K. McKemey, Zhihua Zhang, Roberto Dell'Orso, G. Blaylock, B. Camanzi, R. S. Panvini, D. L. Burke, D. Falciai, R. Cotton, I. Karliner, M. G. Strauss, W. M. Bugg, Richard Dubois, J. Quigley, M. Kalelkar, D. J. Jackson, A. Sugiyama, Minghui Liu, Wit Busza, H.J. Kang, J.J. Reidy, S. L. White, Stephen Robert Wagner, U. Schneekloth, B. I. Eisenstein, D. J. Sherden, J. Ma, T. W. Reeves, Koji Abe, P. C. Rowson, F. Suekane, Rino Castaldi, H. O. Cohn, R. Prepost, H. Yuta, P.F. Jacques, R. Massetti, J. Rothberg, I. Abt, R. Messner, D. W. G. S. Leith, R. H. Schindler, K.C. Moffeit, A. W. Weidemann, E. Vella, X. Yang, T.J. Pavel, D. C. Williams, N. B. Sinev, I. M. Peruzzi, E. Mazzucato, S. L. Shapiro, K. Furuno, Shiro Suzuki, A. Szumilo, G. D. Punkar, T. Schalk, V.V. Serbo, R. Frey, L.S. Rochester, Y. Iwasaki, T. L. Usher, F. E. Taylor, Yukio Hasegawa, T. Maruyama, T. Gillman, J. A. Snyder, H. Park, G. B. Word, M.E. Huffer, A.B. d'Oliveira, J. R. Bogart, D. G. Coyne, J. A. Coller, R. Kroeger, J. R. Johnson, R. Kajikawa, Martin Breidenbach, T. Bienz, R. Ben-David, Stephen Watts, Melody A. Swartz, J. Zhou, C. Vannini, M. Woods, J. J. Russell, L.S. Osborne, R. K. Yamamoto, Philip Burrows, R. E. Cassell, P.E. Rensing, H. L. Lynch, R. A. Johnson, V. Cook, R. de Sangro, W. J. Wisniewski, D. Aston, P.Y.C. Du, A. Seiden, G. Hallewell, S. J. Yellin, S. Manly, M.B. Barakat, R. Cowan, S. Sen, C. C. Young, N.M. Krishna, J. A. Jaros, M. Daoudi, Piero Giorgio Verdini, Dario Bisello, D. Calloway, Alberto Benvenuti, W. W. Ash, Michael J. Fero, E. R. Weiss, H. Kawahara, Tadayuki Takahashi, R. W. Zdarko, M.E. King, K.D. Shmakov, Giancarlo Mantovani, B. Mours, M. Cavalli-Sforza, B. T. Meadows, H. Hwang, R. King, M. H. Shaevitz, N.J. Allen, K. T. Pitts, J. Va’vra, Y. Ohnishi, M. D. Hildreth, D. O. Caldwell, X. Liu, S. S. Hertzbach, Henry W. Kendall, T. H. Burnett, Amitabh Lath, G. Muller, R. R. Kofler, J. A. Lauber, and J. D. Turk
Subjects: Physics, Nuclear and High Energy Physics, Interaction point, Pixel, Electron–positron annihilation, Vertex detector, Atomic physics, Impact parameter, Vertex (geometry)
Abstract: We present measurements of Rb using the SLD at the SLC. The analyses use 2D and 3D impact parameter tags and a displaced 3D vertex tag which all exploit the small size and stability of the e+e- interaction point and the precision 3D CCD pixel vertex detector to achieve high bb¯-tagging efficiencies and purities. The combined measurement yields Rb=0.229±0.011 and is consistent with standard model predictions.
Published: 1996
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31. Influence of dressing changes on wound temperature

Author: E Vella, William McGuiness, and D Harrison
Subjects: Adult, medicine.medical_specialty, Time Factors, Nursing (miscellaneous), integumentary system, Alginates, business.industry, Surgical debridement, Skin temperature, Sodium Chloride, Skin Care, equipment and supplies, Bandages, Dressing change, Clinical Nursing Research, Surgery, Thermography, medicine, Humans, Wounds and Injuries, Fundamentals and skills, Skin Temperature, business, human activities, Bandages, Hydrocolloid
Abstract: Objective: When wound-tissue temperature falls below 33ºC neutrophil, fibroblast and epithelial cell activity decreases. This study examined the influence of dressing changes on wound temperature. Method: The wound-bed temperatures of patients with a wound resulting from trauma or surgical debridement were measured immediately before and after dressing changes using a DermaTemp infrared body surface scanning device. The temperature on the surface of the dressing product was measured immediately before the dressing change and then every five minutes it until the pre-procedural temperature was reached. Results: A total of 133 dressing episodes were measured, yielding 266 wound-bed temperature measurements and 619 external dressing temperature measurements. Pre-procedural temperatures showed that the wound beds were on average marginally below the 33ºC threshold immediately after dressing takedown (mean: 32.7ºC). This figure dropped two degrees on average as a result of the dressing-change procedure (mean: 29.9ºC). Reapplied wound-dressing products return to the pre-procedural temperature within 30 minutes (mean: 23 minutes). Conclusion: This study provides baseline data for future research aimed at promoting maintenance of a normothermic wound bed. Declaration of interest: None.
Published: 2004
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32. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice

Author: Lilas Hadji, Marine L. Croze, Nicolas J. Pillon, Roxane E. Vella, Hédi Soula, Michel Guichardant, Christophe O. Soulage, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Artificial Evolution and Computational Biology (BEAGLE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2), INSERM, INSA-Lyon, French Ministere de la Recherche et de la Technologie, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: antioxidant, myo-inositol, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Adipose tissue, Administration, Oral, White adipose tissue, Biochemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Insulin receptor substrate, Adipocyte, Insulin Secretion, Adipocytes, Insulin, Phosphorylation, 0303 health sciences, Glucose tolerance test, Nutrition and Dietetics, medicine.diagnostic_test, fat mass, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], 3. Good health, Oncogene Protein v-akt, Female, Signal Transduction, medicine.medical_specialty, Adipose Tissue, White, 030209 endocrinology & metabolism, Biology, 03 medical and health sciences, Insulin resistance, white adipose tissue, Internal medicine, medicine, Animals, skeletal muscle, Muscle, Skeletal, insulin-sensitizing, Molecular Biology, 030304 developmental biology, Insulin tolerance test, Glucose Tolerance Test, medicine.disease, Endocrinology, chemistry, Insulin Resistance, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Inositol
Abstract: International audience; Type 2 diabetes is a complex disease characterized by a state of insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue or liver. Some inositol isomers have been reported to possess insulin-mimetic activity and to be efficient in lowering blood glucose level. The aim of the present study was to assess in mice the metabolic effects of a chronic treatment with myo-inositol, the most common stereoisomer of inositol. Mice given myo-inositol treatment (0.9 or 1.2 mg g(-1) day(-1), 15 days, orally or intraperitoneally) exhibited an improved glucose tolerance due to a greater insulin sensitivity. Mice treated with myo-inositol exhibited a decreased white adipose tissue accretion (-33%, P
Published: 2013
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33. p-Cresyl sulfate promotes insulin resistance associated with CKD

Author: Laetitia Koppe, Raymond Vanholder, Christophe O. Soulage, Caroline C. Pelletier, Ziad A. Massy, Stéphane Chambert, Roxane E. Vella, Yann Dugenet, Nicolas J. Pillon, Hédi Soula, Denis Fouque, Marine L. Croze, Griet Glorieux, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire d'Amiens (CHU Amiens-Picardie), CHU Amiens-Picardie, Nephrology Section [Ghent], Ghent University Hospital, Artificial Evolution and Computational Biology (BEAGLE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Witaxos DF3 SAS/BioActor b.v. BioPartner Center, This work was supported by Institut National de la Santé et de la Recherche Médicale (INSERM) and Institut National des Sciences Appliquées de Lyon (INSA-Lyon). L. Koppe held a fellowship from 'Fondation pour la Recherche Médicale' and. C.Pelletier held a grant from 'Société Française de Néphrologie'. N.J. Pillon, M.L. Croze and R.E. Vella were supported by grants from the French Ministère de lʼEducation Nationale, de la Recherche et de la Technologie., Vericel, Evelyne, Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), and Université de Lyon-Université Lumière - Lyon 2 (UL2)
Subjects: MESH: Signal Transduction, medicine.medical_treatment, 030232 urology & nephrology, Adipose tissue, Cresols, Mice, 0302 clinical medicine, Adipocytes, Insulin, MESH: Uremia, MESH: Animals, Extracellular Signal-Regulated MAP Kinases, MESH: Extracellular Signal-Regulated MAP Kinases, MESH: Lipid Metabolism, 0303 health sciences, MESH: Muscle, Skeletal, biology, MESH: Hypercholesterolemia, General Medicine, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], humanities, 3. Good health, MESH: Glucose, MESH: Insulin Resistance, MESH: Cresols, MESH: Adipose Tissue, White, Nephrology, Signal Transduction, medicine.medical_specialty, Adipose Tissue, White, Hypercholesterolemia, MESH: Renal Insufficiency, Chronic, MESH: Insulin, Sulfuric Acid Esters, Carbohydrate metabolism, 03 medical and health sciences, Insulin resistance, MESH: Mice, Inbred C57BL, Internal medicine, Diabetes mellitus, medicine, Animals, Renal Insufficiency, Chronic, Muscle, Skeletal, MESH: Mice, Pancreatic hormone, MESH: Adipocytes, Uremia, 030304 developmental biology, business.industry, Lipid Metabolism, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Insulin receptor, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, MESH: Prebiotics, Glucose, Prebiotics, Basic Research, Endocrinology, Hyperglycemia, biology.protein, Insulin Resistance, MESH: Disease Models, Animal, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business, MESH: Hyperglycemia, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Dyslipidemia
Abstract: International audience; The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role. One such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism by intestinal microbes. Here, we sought to determine whether PCS contributes to CKD-associated insulin resistance. Administering PCS to mice with normal kidney function for 4 weeks triggered insulin resistance, loss of fat mass, and ectopic redistribution of lipid in muscle and liver, mimicking features associated with CKD. Mice treated with PCS exhibited altered insulin signaling in skeletal muscle through ERK1/2 activation. In addition, exposing C2C12 myotubes to concentrations of PCS observed in CKD caused insulin resistance through direct activation of ERK1/2. Subtotal nephrectomy led to insulin resistance and dyslipidemia in mice, and treatment with the prebiotic arabino-xylo-oligosaccharide, which reduced serum PCS by decreasing intestinal production of p-cresol, prevented these metabolic derangements. Taken together, these data suggest that PCS contributes to insulin resistance and that targeting PCS may be a therapeutic strategy in CKD.
Published: 2013
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34. First Measurement of theT-Odd Correlation between theZ0Spin and the Three-Jet Plane Orientation in PolarizedZ0Decays into Three Jets

Author: K. Abe, I. Abt, C. J. Ahn, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. Barklow, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, T. Bienz, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, A. D'Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, P. De Simone, R. Dell'Orso, M. Dima, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, D. Falciai, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, Y. Hasegawa, S. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, H. J. Kang, I. Karliner, H. Kawahara, H. W. Kendall, Y. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. Leith, M. X. Liu, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, R. Massetti, H. Masuda, T. S. Mattison, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, B. Mours, G. Müller, D. Muller, T. Nagamine, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, J. Reidy, P. E. Rensing, L. S. Rochester, J. E. Rothberg, P. C. Rowson, J. J. Russell, O. H. Saxton, S. F. Schaffner, T. Schalk, R. H. Schindler, U. Schneekloth, B. A. Schumm, A. Seiden, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, S. L. Shapiro, D. J. Sherden, K. D. Shmakov, C. Simopoulos, N. B. Sinev, S. R. Smith, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, J. D. Turk, T. Usher, J. Va'vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. R. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, C. Zeitlin, Z. Zhang, and J. Zhou
Subjects: Physics, Particle decay, Particle physics, Triple product, Electron–positron annihilation, Plane orientation, General Physics and Astronomy, Expectation value, Atomic physics
Abstract: We present the first measurement of the correlation between the {ital Z}{sup 0} spin and the event-plane orientation in polarized {ital Z}{sup 0} decays into three jets in the SLAC Linear Collider Large Detector experiment at SLAC utilizing a longitudinally polarized electron beam. The {ital CP}-even and {ital T}-odd triple product {ital {rvec S}}{sub {ital Z}}{center_dot}({ital {rvec k}}{sub 1}{times}{ital {rvec k}}{sub 2}), formed from the two fastest jet momenta {ital {rvec k}}{sub 1} and {ital {rvec k}}{sub 2} and the {ital Z}{sup 0} polarization vector {ital {rvec S}}{sub {ital Z}}, is sensitive to physics beyond the standard model. We measure the expectation value of this quantity to be consistent with zero and set 95% C.L. limits of {minus}0.022{lt}{beta}{lt}0.039 on the correlation. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.
Published: 1995
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35. Measurement of the Left-Right Forward-Backward Asymmetry for Charm Quarks withD*+andD+Mesons

Author: E. Church, T. Junk, A. P. Waite, P. Stamer, I. M. Peruzzi, Gian Mario Bilei, R.J. Plano, E. R. Weiss, A. Seiden, R. Cotton, C. Y. Prescott, K.G. Baird, D. Falciai, W. J. Wisniewski, U. Nauenberg, M. Dima, David A. Williams, A. K. McKemey, S. Willocq, N.J. Allen, F. E. Taylor, J. R. Bogart, D. Su, D. L. Burke, U. Schneekloth, G. Blaylock, Alberto Benvenuti, W. M. Bugg, M. Piccolo, T. Schalk, R. Dubois, R. Messner, G. Mancinelli, P.Y.C. Du, F. Suekane, Brian Meadows, H. Kawahara, D. J. Sherden, C. C. Young, E. Vella, Y. Ohnishi, P. N. Burrows, A. Szumilo, D. W. G. S. Leith, Dario Bisello, S. R. Smith, Rafe Schindler, M. Daoudi, T. Bienz, R. K. Yamamoto, T. W. Reeves, Koji Abe, R. Prepost, M. J. Fero, Robert Wilson, H. M. Steiner, P.F. Jacques, J. J. Russell, X. Yang, D. C. Williams, R. Ben-David, J. A. Coller, A. S. Johnson, J. M. Yamartino, J. Zhou, R. Kroeger, B. Mours, A. O. Bazarko, M. G. Strauss, T. Akagi, J. S. Whitaker, L. Piemontese, M. Nussbaum, K. T. Pitts, S. J. Yellin, B. Camanzi, S. Sen, Enrico Pieroni, R. King, Shinzo Suzuki, C. Simopoulos, D. J. Jackson, Martin Breidenbach, J. A. Snyder, M. Langston, A. Lu, J. E. Brau, A. Calcaterra, T. Gillman, A. Lath, J.P. Venuti, J. F. Labs, A. W. Weidemann, O. Bardon, David O. Caldwell, C.J.S. Damerell, S. Manly, N.M. Krishna, B. N. Ratcliff, V. Cook, R. de Sangro, C. Fan, T.J. Pavel, B. A. Schumm, R. Frey, L. S. Osborne, R.D. Elia, R. W. Zdarko, R.A. Johnson, M.E. King, G. Hallewell, G. E. Gladding, T. Bolton, Timothy Barklow, J. Ma, E. W. Hughes, Zhihua Zhang, C. Baltay, H. Masuda, M. E. Huffer, J. R. Johnson, O. H. Saxton, E. Mazzucato, E. Torrence, V. V. Serbo, H. R. Band, Gilbert Shapiro, J. A. Jaros, M. Cavalli-Sforza, R. Verdier, E. L. Hart, S. H. Williams, R. S. Panvini, Y. Iwasaki, T. L. Usher, Wit Busza, M. Woods, Fred Wickens, H. Park, H. A. Neal, P. M. Mockett, J. Huber, K.C. Moffeit, M. D. Hildreth, G. R. Bower, James Shank, I. Karliner, Dominik Müller, Andrea Castro, K. Furuno, T. Maruyama, C. Vannini, P. De Simone, Michael H. Shaevitz, Yukio Hasegawa, M. Loreti, Roberto Dell'Orso, J. Va'vra, B. I. Eisenstein, D. G. Coyne, T. Nagamine, Y. Kim, R. Steiner, S. Gonzalez, A. Sugiyama, H. L. Lynch, J. Rothberg, I. Abt, D. Aston, D. Calloway, N. B. Sinev, S. Hedges, G. B. Word, M. Swartz, J. Wyss, C. Zeitlin, R. Kajikawa, G. H. Zapalac, M. Kalelkar, P. C. Rowson, H. Yuta, C. J. Ahn, Stephen Watts, M.B. Barakat, S. L. Shapiro, Rino Castaldi, H. O. Cohn, R. Massetti, G. D. Punkar, X. Liu, J. D. Turk, S. S. Hertzbach, L. S. Rochester, M. Carpinelli, Henry W. Kendall, W. W. Ash, R. E. Cassell, P.E. Rensing, T. H. Burnett, J. A. Lauber, R. Cowan, J. Quigley, T. Takahashi, Stephen Robert Wagner, G. Muller, R. R. Kofler, Piero Giorgio Verdini, Giancarlo Mantovani, H. Hwang, G. Baranko, S. L. White, A.B. d'Oliveira, and Thomas W. Markiewicz
Subjects: Physics, Particle physics, Meson, media_common.quotation_subject, Hadron, General Physics and Astronomy, Forward backward, Asymmetry, Charm quark, media_common
Abstract: We present a direct measurement of {ital A}{sub {ital c}}=2{ital v}{sub {ital c}}{ital a}{sub {ital c}}/({ital v}{sup 2}{sub {ital c}}+{ital a}{sup 2}{sub {ital c}}) from the left-right forward-backward asymmetry of {ital D}{sup *}+ and {ital D}{sup +} mesons in {ital Z}{sup 0} events produced with the longitudinally polarized SLAC Linear Collider beam. These {ital Z}{sup 0}{r_arrow}{ital c} over bar events are tagged on the basis of event kinematics and decay topology from a sample of hadronic {ital Z}{sup 0} decays recorded by the SLAC Large Detector. We measure {ital A}{sup 0}{sub {ital c}} = 0.73 {plus_minus} 0.22(stat) {plus_minus} 0.10(syst). {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.
Published: 1995
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36. Measurement of the AverageBHadron Lifetime inZ0Decays Using Reconstructed Vertices

Author: X. Yang, D. C. Williams, R. Ben-David, J. Zhou, Martin Breidenbach, Stephen Watts, M. D. Hildreth, J. Reidy, C. Y. Prescott, D. Su, U. Nauenberg, M. Piccolo, M.B. Barakat, Gian Mario Bilei, P. N. Burrows, M. G. Strauss, T. Akagi, R. Dubois, L. Piemontese, B. Camanzi, Robert Wilson, Enrico Pieroni, J. F. Labs, J. A. Coller, Dario Bisello, J. M. Yamartino, R. Cotton, E. Church, K. T. Pitts, T. Junk, Y. Ohnishi, I. M. Peruzzi, G. R. Bower, J. Quigley, T. Takahashi, James Shank, V. Cook, R. de Sangro, Michael J. Fero, Minghui Liu, S. Hedges, T. Nagamine, Andrea Castro, M. Nussbaum, T. Gillman, G. Hallewell, U. Schneekloth, S. Willocq, Y. Kim, Stephen Robert Wagner, R.J. Plano, V. V. Serbo, A. Sugiyama, D. Aston, A. Seiden, F. Suekane, Brian Meadows, N.J. Allen, D. Calloway, M. Carpinelli, S. F. Schaffner, S. L. Shapiro, K.D. Shmakov, W. J. Wisniewski, J. Ma, J. A. Snyder, F. E. Taylor, G. B. Word, J. R. Bogart, A. Lath, E. Torrence, H. J. Kang, D. Falciai, T. Bolton, Y. Iwasaki, T. L. Usher, H. Park, G. Blaylock, D. J. Sherden, B. Mours, Rafe Schindler, D. W. G. S. Leith, A. S. Johnson, Roberto Dell'Orso, H. A. Neal, C. Baltay, H. Masuda, J. Va'vra, R.D. Elia, G. E. Gladding, M. Swartz, W. W. Ash, Gilbert Shapiro, Shinzo Suzuki, M. Langston, A. I. Trandafir, O. Bardon, David O. Caldwell, A. P. Waite, H. L. Lynch, J. Rothberg, H. Kawahara, S. Manly, I. Abt, R. Verdier, J. Wyss, E. R. Weiss, R. E. Cassell, P.E. Rensing, Timothy Barklow, N. B. Sinev, E. L. Hart, T. H. Burnett, R. Cowan, C. Zeitlin, C. Fan, Wit Busza, R. Kajikawa, R. King, T.J. Pavel, D. J. Jackson, K. Furuno, R. W. Zdarko, B. A. Schumm, R. Frey, Yukio Hasegawa, G. H. Zapalac, M.E. King, S. R. Smith, T. W. Reeves, M. Kalelkar, Koji Abe, J. R. Johnson, P. Stamer, J. D. Turk, P. C. Rowson, H. Yuta, A. W. Weidemann, J. A. Lauber, L. S. Rochester, K.G. Baird, H. M. Steiner, David A. Williams, A. K. McKemey, R. Messner, E. Vella, A.C. Benvenuti, C. Simopoulos, A. Lu, X. Liu, Piero Giorgio Verdini, S. S. Hertzbach, J. A. Jaros, Zhihua Zhang, Rino Castaldi, H. O. Cohn, M. E. Huffer, Henry W. Kendall, Giancarlo Mantovani, R. Massetti, R. Prepost, H. Hwang, P.F. Jacques, G. D. Punkar, G. Muller, R. R. Kofler, A. Szumilo, D. L. Burke, K.C. Moffeit, W. M. Bugg, R. Kroeger, M. Cavalli-Sforza, M. Woods, G. Mancinelli, P.Y.C. Du, R. Steiner, M. Daoudi, S. Gonzalez, C. J. Ahn, A. O. Bazarko, J. E. Brau, Thomas W. Markiewicz, C. Vannini, A. Calcaterra, P. M. Mockett, P. De Simone, Michael H. Shaevitz, J. Huber, G. Baranko, M. Loreti, T. Maruyama, E. W. Hughes, S. L. White, S. H. Williams, I. Karliner, Dominik Müller, B. N. Ratcliff, B. I. Eisenstein, A.B. d'Oliveira, L. S. Osborne, R.A. Johnson, E. Mazzucato, D. G. Coyne, O. H. Saxton, H. R. Band, R. S. Panvini, Fred Wickens, C. C. Young, T. Schalk, S. J. Yellin, S. Sen, N.M. Krishna, R. K. Yamamoto, J. J. Russell, J. S. Whitaker, J.P. Venuti, C.J.S. Damerell, and M. Dima
Subjects: Nuclear physics, Physics, Particle decay, Particle physics, Maximum likelihood, Hadron, Decay length, General Physics and Astronomy, B meson
Abstract: We report a measurement of the average {ital B} hadron lifetime using data collected with the SLD detector at the SLAC Linear Collider in 1993. An inclusive analysis selected three-dimensional vertices with {ital B} hadron lifetime information in a sample of 50{times}10{sup 3} {ital Z}{sup 0} decays. A lifetime of 1.564{plus_minus}0.030(stat){plus_minus}0.036(syst) ps was extracted from the decay length distribution of these vertices using a binned maximum likelihood method. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.
Published: 1995
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37. Comparison of a new calculation of energy-energy correlations withe+e−→ hadrons data at theZ0resonance

Author: K. Abe, I. Abt, C. J. Ahn, T. Akagi, N. J. Allen, W. W. Ash, D. Aston, K. G. Baird, C. Baltay, H. R. Band, M. B. Barakat, G. Baranko, O. Bardon, T. Barklow, A. O. Bazarko, R. Ben-David, A. C. Benvenuti, T. Bienz, G. M. Bilei, D. Bisello, G. Blaylock, J. R. Bogart, T. Bolton, G. R. Bower, J. E. Brau, M. Breidenbach, W. M. Bugg, D. Burke, T. H. Burnett, P. N. Burrows, W. Busza, A. Calcaterra, D. O. Caldwell, D. Calloway, B. Camanzi, M. Carpinelli, R. Cassell, R. Castaldi, A. Castro, M. Cavalli-Sforza, E. Church, H. O. Cohn, J. A. Coller, V. Cook, R. Cotton, R. F. Cowan, D. G. Coyne, A. D’Oliveira, C. J. S. Damerell, M. Daoudi, R. De Sangro, P. De Simone, R. Dell’Orso, M. Dima, P. Y. C. Du, R. Dubois, B. I. Eisenstein, R. Elia, D. Falciai, C. Fan, M. J. Fero, R. Frey, K. Furuno, T. Gillman, G. Gladding, S. Gonzalez, G. D. Hallewell, E. L. Hart, Y. Hasegawa, S. Hedges, S. S. Hertzbach, M. D. Hildreth, J. Huber, M. E. Huffer, E. W. Hughes, H. Hwang, Y. Iwasaki, D. J. Jackson, P. Jacques, J. Jaros, A. S. Johnson, J. R. Johnson, R. A. Johnson, T. Junk, R. Kajikawa, M. Kalelkar, I. Karliner, H. Kawahara, H. W. Kendall, Y. Kim, M. E. King, R. King, R. R. Kofler, N. M. Krishna, R. S. Kroeger, J. F. Labs, M. Langston, A. Lath, J. A. Lauber, D. W. G. Leith, X. Liu, M. Loreti, A. Lu, H. L. Lynch, J. Ma, G. Mancinelli, S. Manly, G. Mantovani, T. W. Markiewicz, T. Maruyama, R. Massetti, H. Masuda, E. Mazzucato, A. K. McKemey, B. T. Meadows, R. Messner, P. M. Mockett, K. C. Moffeit, B. Mours, G. Müller, D. Muller, T. Nagamine, U. Nauenberg, H. Neal, M. Nussbaum, Y. Ohnishi, L. S. Osborne, R. S. Panvini, H. Park, T. J. Pavel, I. Peruzzi, M. Piccolo, L. Piemontese, E. Pieroni, K. T. Pitts, R. J. Plano, R. Prepost, C. Y. Prescott, G. D. Punkar, J. Quigley, B. N. Ratcliff, T. W. Reeves, P. E. Rensing, L. S. Rochester, J. E. Rothberg, P. C. Rowson, J. J. Russell, O. H. Saxton, T. Schalk, R. H. Schindler, U. Schneekloth, B. A. Schumm, A. Seiden, S. Sen, V. V. Serbo, M. H. Shaevitz, J. T. Shank, G. Shapiro, S. L. Shapiro, D. J. Sherden, C. Simopoulos, N. B. Sinev, S. R. Smith, J. A. Snyder, P. Stamer, H. Steiner, R. Steiner, M. G. Strauss, D. Su, F. Suekane, A. Sugiyama, S. Suzuki, M. Swartz, A. Szumilo, T. Takahashi, F. E. Taylor, E. Torrence, J. D. Turk, T. Usher, J. Va’vra, C. Vannini, E. Vella, J. P. Venuti, R. Verdier, P. G. Verdini, S. R. Wagner, A. P. Waite, S. J. Watts, A. W. Weidemann, E. Weiss, J. S. Whitaker, S. L. White, F. J. Wickens, D. A. Williams, D. C. Williams, S. H. Williams, S. Willocq, R. J. Wilson, W. J. Wisniewski, M. Woods, G. B. Word, J. Wyss, R. K. Yamamoto, J. M. Yamartino, X. Yang, S. J. Yellin, C. C. Young, H. Yuta, G. Zapalac, R. W. Zdarko, C. Zeitlin, Z. Zhang, and J. Zhou
Subjects: Quantum chromodynamics, Physics, Particle physics, Crystallography, Annihilation, Electron–positron annihilation, Hadron, Resonance, Energy (signal processing)
Abstract: We have compared a new QCD calculation by Clay and Ellis of energy-energy correlations (EEC`s) and their asymmetry (AEEC`s) in {ital e}{sup +}{ital e}{sup {minus}} annihilation into hadrons with data collected by the SLD experiment at SLAC. From fits of the new calculation, complete at {ital O}({alpha}{sub {ital s}}{sup 2}), we obtained {alpha}{sub {ital s}}({ital M}{sub {ital Z}}{sup 2})=0.1184{plus_minus}0.0031(expt){plus_minus}0.0129(theory) (EEC) and {alpha}{sub {ital s}}({ital M}{sub {ital Z}}{sup 2})=0.1120{plus_minus}0.0034(expt){plus_minus}0.0036(theory) (AEEC). The EEC result is significantly lower than that obtained from comparable fits using the {ital O}({alpha}{sub {ital s}}{sup 2}) calculation of Kunszt and Nason.
Published: 1995
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38. Polarized Bhabha Scattering and a Precision Measurement of the Electron Neutral Current Couplings

Author: C. Fan, T.J. Pavel, C. Simopoulos, R. Frey, M. Dima, A. Lu, G. M. Bilei, G. R. Bower, J. R. Johnson, James Shank, R. E. Cassell, P.E. Rensing, Andrea Castro, S. Dasu, M. E. Huffer, Robert Wilson, J. A. Coller, K. T. Pitts, V. Cook, R. de Sangro, G. Hallewell, T. H. Burnett, J. Wyss, K. Furuno, Yukio Hasegawa, D. Falciai, R. Cowan, C. Zeitlin, R. Kajikawa, Rafe Schindler, H. Steiner, D. G. Coyne, I. M. Peruzzi, E. Mazzucato, R. Ben-David, J. Zhou, T. Bolton, R. Dubois, C. C. Young, G. H. Zapalac, M. Kalelkar, A. Seiden, H. A. Neal, K.C. Moffeit, G. Shapiro, B. Camanzi, R. Steiner, P.Y.C. Du, B. Mours, S. Gonzalez, E. L. Hart, G. Blaylock, S. J. Yellin, Alberto Benvenuti, C. J. Ahn, R.D. Elia, G. E. Gladding, C. Y. Prescott, S. Sen, Y. Ohnishi, W. J. Wisniewski, J. E. Brau, N.M. Krishna, A. S. Johnson, H. Kawahara, A. O. Bazarko, A. Calcaterra, Y. Iwasaki, T. L. Usher, J.P. Venuti, H. Park, F. E. Taylor, T. Maruyama, D. J. Sherden, J. M. Yamartino, C.J.S. Damerell, J. R. Bogart, C. Baltay, H. Masuda, J. Quigley, T. Takahashi, B. N. Ratcliff, R. King, T. Gillman, T. Nagamine, E. W. Hughes, S. H. Williams, D. W. G. S. Leith, C. Vannini, P. De Simone, Michael H. Shaevitz, L. Pescara, S. Hedges, Stephen Robert Wagner, D. Su, Y. Kim, M. Carpinelli, P. Stamer, M. Loreti, Wit Busza, A. P. Waite, D. L. Burke, O. H. Saxton, W. M. Bugg, M. Piccolo, M. Cavalli-Sforza, A. Sugiyama, G. B. Word, M. Nussbaum, D. Aston, R. Cotton, H. R. Band, Shinzo Suzuki, Nicola Bacchetta, M. Woods, V. V. Serbo, Thomas W. Markiewicz, U. Schneekloth, E. Torrence, Rino Castaldi, H. O. Cohn, R. Massetti, D. Calloway, M. Langston, O. Bardon, David O. Caldwell, M. G. Strauss, T. Akagi, L. Piemontese, F. Suekane, G. Baranko, G. D. Punkar, J. D. Turk, W. W. Ash, Brian Meadows, B. A. Schumm, Enrico Pieroni, M. Swartz, R. S. Panvini, S. L. White, L. S. Rochester, Timothy Barklow, S. R. Smith, J. F. Labs, T. W. Reeves, Koji Abe, T. Schalk, Michael J. Fero, X. Yang, K.G. Baird, J. Ma, Fred Wickens, D. C. Williams, A.B. d'Oliveira, David A. Williams, A. K. McKemey, S. Willocq, U. Nauenberg, M. D. Hildreth, S. L. Shapiro, T. Bienz, Martin Breidenbach, Roberto Dell'Orso, R. K. Yamamoto, Stephen Watts, Piero Giorgio Verdini, P. N. Burrows, Dario Bisello, J. Va'vra, Giancarlo Mantovani, P. C. Rowson, H. Hwang, J. J. Russell, R. Messner, M.B. Barakat, L.S. Osborne, J. A. Snyder, J. S. Whitaker, H. L. Lynch, J. Rothberg, R. A. Johnson, H. Yuta, I. Abt, E. Vella, N. B. Sinev, G. Mancinelli, E. Church, T. Junk, R.J. Plano, S. Manly, R. W. Zdarko, M.E. King, R. Prepost, P.F. Jacques, X. Liu, S. S. Hertzbach, Henry W. Kendall, A. W. Weidemann, Amitabh Lath, G. Muller, R. R. Kofler, J. A. Lauber, J. A. Jaros, A. Szumilo, R. Kroeger, P. M. Mockett, J. Huber, I. Karliner, Dominik Müller, B. I. Eisenstein, Abe, K, Abt, I, Ahn, C, Akagi, T, Ash, W, Aston, D, Bacchetta, N, Baird, K, Baltay, C, Band, H, Barakat, M, Baranko, G, Bardon, O, Barklow, T, Bazarko, A, Bendavid, R, Benvenuti, A, Bienz, T, Bilei, G, Bisello, D, Blaylock, G, Bogart, J, Bolton, T, Bower, G, Brau, J, Breidenbach, M, Bugg, W, Burke, D, Burnett, T, Burrows, P, Busza, W, Calcaterra, A, Caldwell, D, Calloway, D, Camanzi, B, Carpinelli, M, Cassell, R, Castaldi, R, Castro, A, Cavallisforza, M, Church, E, Cohn, H, Coller, J, Cook, V, Cotton, R, Cowan, R, Coyne, D, Doliveira, A, Damerell, C, Dasu, S, Desangro, R, Desimone, P, Dellorso, R, Dima, M, Du, P, Dubois, R, Eisenstein, B, Elia, R, Falciai, D, Fan, C, Fero, M, Frey, R, Furuno, K, Gillman, T, Gladding, G, Gonzalez, S, Hallewell, G, Hart, E, Hasegawa, Y, Hedges, S, Hertzbach, S, Hildreth, M, Huber, J, Huffer, M, Hughes, E, Hwang, H, Iwasaki, Y, Jacques, P, Jaros, J, Johnson, A, Johnson, J, Johnson, R, Junk, T, Kajikawa, R, Kalelkar, M, Karliner, I, Kawahara, H, Kendall, H, Kim, Y, King, M, King, R, Kofler, R, Krishna, N, Kroeger, R, Labs, J, Langston, M, Lath, A, Lauber, J, Leith, D, Liu, X, Loreti, M, Lu, A, Lynch, H, Ma, J, Mancinelli, G, Manly, S, Mantovani, G, Markiewicz, T, Maruyama, T, Massetti, R, Masuda, H, Mazzucato, E, Mckemey, A, Meadows, B, Messner, R, Mockett, P, Moffeit, K, Mours, B, Muller, G, Muller, D, Nagamine, T, Nauenberg, U, Neal, H, Nussbaum, M, Ohnishi, Y, Osborne, L, Panvini, R, Park, H, Pavel, T, Peruzzi, I, Pescara, L, Piccolo, M, Piemontese, L, Pieroni, E, Pitts, K, Plano, R, Prepost, R, Prescott, C, Punkar, G, Quigley, J, Ratcliff, B, Reeves, T, Rensing, P, Rochester, L, Rothberg, J, Rowson, P, Russell, J, Saxton, O, Schalk, T, Schindler, R, Schneekloth, U, Schumm, B, Seiden, A, Sen, S, Serbo, V, Shaevitz, M, Shank, J, Shapiro, G, Shapiro, S, Sherden, D, Simopoulos, C, Sinev, N, Smith, S, Snyder, J, Stamer, P, Steiner, H, Steiner, R, Strauss, M, Su, D, Suekane, F, Sugiyama, A, Suzuki, S, Swartz, M, Szumilo, A, Takahashi, T, Taylor, F, Torrence, E, Turk, J, Usher, T, Vavra, J, Vannini, C, Vella, E, Venuti, J, Verdini, P, Wagner, S, Waite, A, Watts, S, Weidemann, A, Whitaker, J, White, S, Wickens, F, Williams, D, Williams, S, Willocq, S, Wilson, R, Wisniewski, W, Woods, M, Word, G, Wyss, J, Yamamoto, R, Yamartino, J, Yang, X, Yellin, S, Young, C, Yuta, H, Zapalac, G, Zdarko, R, Zeitlin, C, and Zhou, J
Subjects: 010302 applied physics, Physics, Coupling, Particle physics, Neutral current, 010308 nuclear & particles physics, FOS: Physical sciences, General Physics and Astronomy, Resonance, Weinberg angle, Electron, 01 natural sciences, Physics::History of Physics, High Energy Physics - Experiment, Standard Model, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, High Energy Physics::Experiment, Bhabha scattering
Abstract: We present the first measurement of the left-right asymmetry in Bhabha scattering with a polarized electron beam. The effective electron vector and axial vector couplings to the Z0 are extracted from a combined analysis of the polarized Bhabha scattering data and the left-right asymmetry previously published by this collaboration., PHYZZX, 17 pages, SLAC-PUB-6605
Published: 1995

39. Measurement of the Parity-Violation ParametersAbandAcfrom the Left-Right Forward-Backward Asymmetry of Leptons in Hadronic Events at theZ0Resonance

Author: C. Y. Prescott, G. R. Bower, James Shank, D. Su, Andrea Castro, D. Falciai, J.P. Venuti, C.J.S. Damerell, M. Dima, L. S. Osborne, M. Piccolo, E. Church, T. Junk, J. A. Snyder, A. Lath, M. Nussbaum, A. P. Waite, A. Seiden, R.J. Plano, Rino Castaldi, H. O. Cohn, R. Massetti, H. A. Neal, O. H. Saxton, G. Blaylock, R.D. Elia, G. E. Gladding, G. D. Punkar, C. Baltay, H. Masuda, Shinzo Suzuki, J. Ma, H. R. Band, Rafe Schindler, Alberto Benvenuti, M. Langston, O. Bardon, T. Gillman, Wit Busza, U. Nauenberg, R. Ben-David, David O. Caldwell, R. S. Panvini, Fred Wickens, H. Kawahara, S. Hedges, G. B. Word, Robert Wilson, T. Schalk, C. C. Young, X. Yang, J. Zhou, D. C. Williams, J. Quigley, T. Takahashi, Timothy Barklow, Stephen Robert Wagner, J. A. Coller, E. Torrence, J. E. Brau, A. Calcaterra, K. T. Pitts, T. Bienz, R. K. Yamamoto, S. Dasu, S. J. Yellin, S. Sen, P. N. Burrows, Dario Bisello, L. Pescara, N.M. Krishna, J. D. Turk, Martin Breidenbach, T. Nagamine, M. Carpinelli, M. Swartz, A. S. Johnson, V. Cook, R. de Sangro, J. J. Russell, R. King, J. M. Yamartino, Roberto Dell'Orso, L. S. Rochester, K. Furuno, G. Hallewell, J. Va'vra, Y. Iwasaki, T. L. Usher, Yukio Hasegawa, R. Kajikawa, H. Park, J. S. Whitaker, E. W. Hughes, H. L. Lynch, S. H. Williams, J. Rothberg, I. Abt, Y. Kim, D. J. Sherden, R. A. Johnson, G. H. Zapalac, D. G. Coyne, C. Fan, A. Sugiyama, W. W. Ash, D. Aston, D. W. G. S. Leith, B. Mours, N. B. Sinev, T.J. Pavel, T. Maruyama, Gian Mario Bilei, R. Frey, R. Prepost, V. V. Serbo, R. Cotton, P.F. Jacques, J. R. Johnson, D. Calloway, P. C. Rowson, R. E. Cassell, P.E. Rensing, U. Schneekloth, H. Yuta, F. Suekane, Brian Meadows, T. H. Burnett, B. A. Schumm, R. Steiner, R. Cowan, S. Gonzalez, C. J. Ahn, H. Steiner, M. D. Hildreth, J. Wyss, C. Zeitlin, B. Camanzi, M. Kalelkar, K.C. Moffeit, G. Shapiro, R. Messner, A. O. Bazarko, E. Vella, M. G. Strauss, T. Akagi, L. Piemontese, S. R. Smith, T. W. Reeves, Koji Abe, B. N. Ratcliff, Enrico Pieroni, P. Stamer, J. F. Labs, K.G. Baird, David A. Williams, A. K. McKemey, T. Bolton, I. M. Peruzzi, E. Mazzucato, S. Manly, R. W. Zdarko, M.E. King, E. L. Hart, Stephen Watts, M.B. Barakat, C. Vannini, M. Cavalli-Sforza, D. L. Burke, P. De Simone, Michael H. Shaevitz, W. M. Bugg, S. L. Shapiro, M. Loreti, M. Woods, C. Simopoulos, G. Mancinelli, P.Y.C. Du, A. Lu, G. Baranko, S. L. White, A. W. Weidemann, M. E. Huffer, A.B. d'Oliveira, J. A. Jaros, P. M. Mockett, J. Huber, Piero Giorgio Verdini, I. Karliner, Dominik Müller, B. I. Eisenstein, A. Szumilo, Giancarlo Mantovani, M. J. Fero, R. Kroeger, H. Hwang, J. A. Lauber, G. Muller, R. R. Kofler, X. Liu, S. S. Hertzbach, Henry W. Kendall, Nicola Bacchetta, Thomas W. Markiewicz, S. Willocq, R. Dubois, Y. Ohnishi, W. J. Wisniewski, F. E. Taylor, and J. R. Bogart
Subjects: Quark, Physics, Particle decay, Particle physics, Electron–positron annihilation, media_common.quotation_subject, Hadron, General Physics and Astronomy, Parity (physics), Electron, Asymmetry, media_common, Lepton
Abstract: The parity-violating parameters ${A}_{b}$ and ${A}_{c}$ are directly measured by the SLD experiment at the SLAC Linear Collider in ${e}^{+}{e}^{\ensuremath{-}}$ collisions with polarized electrons at the ${Z}^{0}$ resonance. Leptons with distinctive total and transverse momenta are used to select and analyze ${Z}^{0}\ensuremath{\rightarrow}b\overline{b}$ and ${Z}^{0}\ensuremath{\rightarrow}c\overline{c}$ events. ${A}_{b}$ and ${A}_{c}$ are extracted by forming the left-right forward-backward asymmetry in electron beam polarization and quark polar angle. From our 1993 sample of 1.8 p${\mathrm{b}}^{--1}$ of ${Z}^{0}$ decay data with an average electron beam polarization of 63% we find ${A}_{b}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.91\ifmmode\pm\else\textpm\fi{}0.14$ (stat) $\ifmmode\pm\else\textpm\fi{}0.07$ (syst) and ${A}_{c}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.37\ifmmode\pm\else\textpm\fi{}0.23$ (stat) $\ifmmode\pm\else\textpm\fi{}0.21$ (syst).
Published: 1995
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40. Measurement of the Parity-Violation ParameterAbfrom the Left-Right Forward-Backward Asymmetry ofbQuark Production inZ0Decays Using a Momentum-Weighted Track-Charge Technique

Author: D. J. Sherden, D. W. G. S. Leith, Roberto Dell'Orso, G. R. Bower, P. C. Rowson, James Shank, Andrea Castro, Stephen Watts, A. Szumilo, C. Y. Prescott, J. Va'vra, H. Yuta, Shinzo Suzuki, M. Langston, T. Schalk, O. Bardon, David O. Caldwell, Timothy Barklow, T. Maruyama, D. Su, K.C. Moffeit, H. L. Lynch, J. Rothberg, I. Abt, M. Dima, G. Shapiro, C. Baltay, H. Masuda, M.B. Barakat, R. Kroeger, G. Mancinelli, P.Y.C. Du, W. J. Wisniewski, E. Church, T. Junk, M. Piccolo, F. E. Taylor, S. Dasu, R. King, S. Hedges, N. B. Sinev, Rino Castaldi, H. O. Cohn, T. Bienz, R. Massetti, R. K. Yamamoto, D. Falciai, G. D. Punkar, S. Manly, J. R. Bogart, A. S. Johnson, A. W. Weidemann, J. A. Lauber, Wit Busza, J. M. Yamartino, T. Bolton, B. Camanzi, G. B. Word, R. Steiner, R.J. Plano, S. Gonzalez, J. Quigley, T. Takahashi, C. J. Ahn, C. Simopoulos, A. Lu, R. W. Zdarko, M.E. King, M. Cavalli-Sforza, J. J. Russell, B. Mours, Stephen Robert Wagner, M. Woods, C. C. Young, X. Yang, J. S. Whitaker, M. Swartz, M. G. Strauss, M. E. Huffer, D. C. Williams, R. Ben-David, T. Akagi, P. Stamer, L. Piemontese, Rafe Schindler, T. Nagamine, Robert Wilson, J. A. Snyder, R. A. Johnson, J. Zhou, Enrico Pieroni, Y. Kim, J. A. Coller, J. A. Jaros, R. Kajikawa, A. Lath, C. Vannini, Michael J. Fero, G. H. Zapalac, J. F. Labs, A. Sugiyama, D. Aston, K. T. Pitts, K.G. Baird, R. E. Cassell, A. P. Waite, P. De Simone, Michael H. Shaevitz, P.E. Rensing, L. Pescara, J. D. Turk, Martin Breidenbach, S. L. Shapiro, S. J. Yellin, David A. Williams, E. L. Hart, S. Willocq, M. Loreti, A. K. McKemey, D. Calloway, J.P. Venuti, M. Carpinelli, J. E. Brau, T. H. Burnett, G. Blaylock, Gian Mario Bilei, A. Calcaterra, B. A. Schumm, V. Cook, R. de Sangro, S. Sen, R. Cowan, R. Messner, V. V. Serbo, L. S. Rochester, P. M. Mockett, E. Vella, G. Hallewell, J. Huber, H. Steiner, L. S. Osborne, N.M. Krishna, W. W. Ash, R. Cotton, H. A. Neal, M. D. Hildreth, O. H. Saxton, X. Liu, S. R. Smith, R. Dubois, I. Karliner, Dominik Müller, T. W. Reeves, S. S. Hertzbach, E. W. Hughes, S. H. Williams, H. R. Band, B. I. Eisenstein, Henry W. Kendall, Koji Abe, Y. Ohnishi, K. Furuno, R. S. Panvini, G. Muller, R. R. Kofler, Fred Wickens, U. Schneekloth, J. Wyss, Yukio Hasegawa, C. Zeitlin, D. G. Coyne, F. Suekane, Brian Meadows, M. Kalelkar, R.D. Elia, G. E. Gladding, A.C. Benvenuti, T. Gillman, E. Torrence, A. Seiden, H. Kawahara, C. Fan, T.J. Pavel, R. Frey, J. R. Johnson, R. Prepost, P.F. Jacques, G. Baranko, S. L. White, A.B. d'Oliveira, U. Nauenberg, P. N. Burrows, Dario Bisello, Y. Iwasaki, T. L. Usher, H. Park, A. O. Bazarko, M. Nussbaum, C.J.S. Damerell, B. N. Ratcliff, Nicola Bacchetta, I. M. Peruzzi, E. Mazzucato, Thomas W. Markiewicz, J. Ma, D. L. Burke, W. M. Bugg, Piero Giorgio Verdini, Giancarlo Mantovani, and H. Hwang
Subjects: Physics, Quark, Particle physics, Particle decay, media_common.quotation_subject, Electron–positron annihilation, General Physics and Astronomy, Parity (physics), Impact parameter, Polarization (waves), Asymmetry, Bottom quark, media_common
Abstract: Using an impact parameter tag to select an enriched sample of {ital Z}{sup 0}{r_arrow}{ital bb}{ovr bar} events, and the net momentum-weighted track charge to identify the sign of the charge of the underlying {ital b} quark, we have measured the left-right forward-backward asymmetry for {ital b} quark production as a function of polar angle. Based on 1.8pb{sup {minus}1} of {ital Z}{sup 0} decay data produced with a mean electron beam polarization of {ital P}{sub {ital e}}=63%, this yields a direct measurement of the extent of parity violation in the {ital Zbb} coupling of {ital A}{sub {ital b}}=0.87{plus_minus}0.11(stat){plus_minus}0.09(syst).
Published: 1995
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41. Search for Jet Handedness in HadronicZ0Decays

Author: Stephen Watts, C. Baltay, H. Masuda, C. Vannini, P. De Simone, Michael H. Shaevitz, J. M. Yamartino, M. Loreti, J. Quigley, T. Takahashi, Stephen Robert Wagner, Wit Busza, R.D. Elia, G. E. Gladding, R. Prepost, M.B. Barakat, Y. Hasegawa, M. Carpinelli, J. Wyss, J.P. Venuti, Piero Giorgio Verdini, P. C. Rowson, P.F. Jacques, R. E. Cassell, P.E. Rensing, O. H. Saxton, H. R. Band, Amitabh Lath, G. Muller, R. R. Kofler, C.J.S. Damerell, W. W. Ash, H. Yuta, P. M. Mockett, J. Huber, C. Zeitlin, R. Steiner, C. Y. Prescott, Giancarlo Mantovani, T. H. Burnett, H. Hwang, S. Gonzalez, M. Cavalli-Sforza, C. J. Ahn, M. Nussbaum, T. Gillman, R. Cowan, M. Dima, R. S. Panvini, C. Simopoulos, I. M. Peruzzi, E. Mazzucato, D. Su, M. Woods, K. Furuno, Fred Wickens, C. Fan, M. Piccolo, G. Baranko, L. Pescara, J. D. Turk, T.J. Pavel, H. Steiner, S. Dasu, B. Camanzi, A. Lu, V. V. Serbo, J. E. Brau, A. Calcaterra, M. E. Huffer, S. L. White, T. Schalk, I. Karliner, Dominik Müller, R. Frey, E. Torrence, S. Willocq, L. S. Rochester, D. J. Sherden, B. Mours, B. I. Eisenstein, J. A. Lauber, E. W. Hughes, T. Bienz, R. K. Yamamoto, D. Falciai, R. King, D. W. G. S. Leith, A.B. d'Oliveira, T. Bolton, M. Kalelkar, D. G. Coyne, J. R. Johnson, S. H. Williams, A. Szumilo, J. J. Russell, S. Manly, B. A. Schumm, S. Hedges, S. L. Shapiro, G. B. Word, J. S. Whitaker, R. A. Johnson, K.C. Moffeit, G. Shapiro, R. W. Zdarko, M.E. King, C. C. Young, G. Mancinelli, P.Y.C. Du, J. Ma, E. L. Hart, J. A. Snyder, H. A. Neal, Rafe Schindler, X. Yang, P. Stamer, M. J. Fero, R. Kroeger, Shinzo Suzuki, M. Langston, S. R. Smith, W. J. Wisniewski, O. Bardon, Gian Mario Bilei, T. W. Reeves, Koji Abe, Robert Wilson, D. C. Williams, Roberto Dell'Orso, M. Swartz, M. D. Hildreth, David O. Caldwell, A. P. Waite, X. Liu, S. S. Hertzbach, J. A. Coller, J. Va'vra, A. S. Johnson, A. Seiden, Rino Castaldi, U. Nauenberg, K.G. Baird, Henry W. Kendall, David A. Williams, F. E. Taylor, S. J. Yellin, H. O. Cohn, A. K. McKemey, S. Sen, K. T. Pitts, R. Massetti, R. Cotton, R. Messner, Timothy Barklow, N.M. Krishna, E. Vella, G. Blaylock, G. D. Punkar, Martin Breidenbach, J. R. Bogart, V. Cook, R. Kajikawa, R. de Sangro, L. S. Osborne, H. L. Lynch, J. Rothberg, G. Hallewell, U. Schneekloth, I. Abt, P. N. Burrows, M. G. Strauss, T. Akagi, N. B. Sinev, G. H. Zapalac, Alberto Benvenuti, G. R. Bower, F. Suekane, Brian Meadows, James Shank, Dario Bisello, Andrea Castro, L. Piemontese, H. Kawahara, A. W. Weidemann, E. Church, T. Nagamine, T. Junk, T. Maruyama, Y. Iwasaki, T. L. Usher, Enrico Pieroni, Y. Kim, R.J. Plano, H. Park, J. F. Labs, A. O. Bazarko, R. Ben-David, A. Sugiyama, D. Aston, Nicola Bacchetta, J. Zhou, Thomas W. Markiewicz, J. A. Jaros, R. Dubois, D. Calloway, Y. Ohnishi, B. N. Ratcliff, D. L. Burke, and W. M. Bugg
Subjects: Quark, Physics, Particle physics, Computer Science::Information Retrieval, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Hadron, General Physics and Astronomy, Elementary particle, Fermion, Polarization (waves), Asymmetry, Nuclear physics, Particle decay, High Energy Physics::Experiment, Boson, media_common
Abstract: We have searched for signatures of polarization in hadronic jets from [ital Z][sup 0][r arrow][ital q[bar q]] decays using the jet handedness'' method. The polar angle asymmetry induced by the high SLAC Linear Collider electron-beam polarization was used to separate quark jets from antiquark jets, expected to be left and right polarized, respectively. We find no evidence for jet handedness in our global sample or in a sample of light quark jets, and we set upper limits at the 95% C.L. of 0.063 and 0.099, respectively, on the magnitude of the analyzing power of the method proposed by Efremov [ital et] [ital al].
Published: 1995
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42. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress

Author: Nicolas J. Pillon, Laurent Soulère, Christophe O. Soulage, Michel Lagarde, Marine L. Croze, and Roxane E. Vella
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Glucose uptake, medicine.disease_cause, Cell Line, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, medicine, Animals, Insulin, Muscle, Skeletal, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Aldehydes, biology, Skeletal muscle, Glutathione, medicine.disease, 3. Good health, Insulin receptor, Oxidative Stress, medicine.anatomical_structure, chemistry, biology.protein, Lipid Peroxidation, Insulin Resistance, Reactive Oxygen Species, 030217 neurology & neurosurgery, Oxidative stress, Signal Transduction
Abstract: Numerous oxidants are produced as by-products of aerobic cell metabolism, and there is growing evidence that they play key roles in the pathogenesis of insulin resistance. Under conditions of oxidative stress, lipid peroxidation of ω6-polyunsaturated fatty acids leads to the production of 4-hydroxy-2-nonenal (4-HNE). Several lines of evidence suggest that 4-HNE could be involved in the pathophysiology of metabolic diseases; therefore, in this study we assessed the direct effects of 4-HNE on skeletal muscle insulin sensitivity. Gastrocnemius muscle and L6 muscle cells were treated with 4-HNE. Insulin signaling was measured by Western blotting and glucose uptake using 2-deoxy-d-[3H]glucose. Carbonyl stress, glutathione content, and oxidative stress were assessed as potential mechanisms leading to insulin resistance. Protection of cells was induced by pretreatment with 3H-1,2-dithiole-3-thione, N-acetyl-cysteine, aminoguanidine, or S-adenosyl-methionine. 4-HNE induced a time- and dose-dependent decrease in insulin signaling and insulin-induced glucose uptake in muscle. It induced a state of carbonyl stress through adduction of proteins as well as a depletion in reduced glutathione and production of radical oxygen species. A pharmacological increase in glutathione pools was achieved by 3H-1,2-dithiole-3-thione and protected the cells against all deleterious effects of 4-HNE; furthermore, N-acetylcysteine, aminoguanidine, and S-adenosylmethionine prevented 4-HNE noxious effects. 4-HNE can impair insulin action in muscle cells through oxidative stress and oxidative damage to proteins, eventually leading to insulin resistance. These deleterious effects can be prevented by pretreatment with antioxidants, scavengers, or an increase in intracellular glutathione pools. Use of such molecules could represent a novel strategy to combat insulin resistance and other oxidative stress-associated pathologies.
Published: 2012

43. Measurement ofαsfrom energy-energy correlations at theZ0resonance

Author: G. Baranko, S. L. White, E. Church, T. Junk, S. Hedges, R. S. Panvini, A. W. Weidemann, R. J. Belcinski, W. J. Wisniewski, R.J. Plano, L.S. Rochester, Y. Iwasaki, T. L. Usher, H. Park, S. J. Yellin, N.M. Krishna, R. Prepost, P.F. Jacques, M. Kowitt, Piero Giorgio Verdini, M. Pauluzzi, J. D. Richman, Giancarlo Mantovani, J. Va’vra, H. Hwang, D. G. Hitlin, D. J. Sherden, T. Nagamine, Nicola Bacchetta, D. O. Caldwell, R. S. Kofler, D. W. G. S. Leith, Koya Abe, G. Eigen, A. D'Oliverira, P. Coyle, E. Torrance, Roberto Battiston, C. Baltay, A. S. Johnson, H. Masuda, P. C. Rowson, Philip Burrows, H. Yuta, J. M. Yamartino, W. A. Majid, Stephen Watts, J. A. Coller, Shiro Suzuki, T. Hansl-Kozanecka, M. Nussbaum, G. Mueller, J. Carr, S. Smith, Wit Busza, K. T. Pitts, Melody A. Swartz, P. Saez, R. Steiner, G. Blaylock, S. Gonzalez, J.P. Venuti, B. Camanzi, Hyun-Chul Kim, J. A. Snyder, D. J. Mellor, G. Mancinelli, P. M. Mockett, M. Langston, A. Lu, M. H. Kelsey, I. Stockdale, O. Bardon, Maurizio Biasini, D. L. Burke, C.J.S. Damerell, R. J. Wilson, Michael S. Witherell, S. Kaiser, Michael J. Fero, J. Ma, G. Agnew, B. Meadows, R. Cotton, X. Liu, W. M. Bugg, S. S. Hertzbach, V. Cook, R. de Sangro, Joseph Izen, K. Furuno, M. Carpinelli, G. H. Zapalac, Yukio Hasegawa, K.C. Moffeit, U. Schneekloth, I. Karliner, M. G. Strauss, Dominik Müller, L. Servoli, T. Maruyama, J.I. Friedman, A. Seiden, M. Cavalli-Sforza, G. Hallewell, Henry W. Kendall, G. B. Word, Elliot Hughes, F. Suekane, S. L. Shapiro, J. Wyss, C. C. Young, U. Nauenberg, G. M. Bilei, G. R. Bower, L. Chen, D. G. Coyne, T. H. Burnett, James Shank, Amitabh Lath, A. Gillman, J. J. Thaler, R. Claus, R. K. Yamamoto, B. I. Eisenstein, C. Zeitlin, M. H. Shaevitz, Andrea Castro, A. K. Honma, R.D. Elia, M. D. Hildreth, G. E. Gladding, O. H. Saxton, T. Bolton, R. H. Schindler, Sridhara Dasu, Roberto Dell'Orso, H. R. Band, A. Szumilo, L. Piemontese, Gilbert Shapiro, Thomas W. Markiewicz, J. Rothberg, I. Abt, Alberto Benvenuti, M. Kalelkar, R. Verdier, W. W. Ash, Enrico Pieroni, E. L. Hart, H. Kawahara, Fred Wickens, R. Kroeger, J. E. Brau, P. Zucchelli, Dario Bisello, J. F. Labs, S. Willocq, A. Calcaterra, A. O. Bazarko, T. Schalk, J. F. McGowan, T. W. Reeves, H. L. Lynch, H. M. Steiner, C. Vannini, S. H. Williams, N. Toge, D.C. Schultz, T. Bienz, A. Sugiyama, P. De Simone, M.D. Sokoloff, R. King, J. J. Russell, Y. C. Du, J. A. Lauber, W. Dunwoodie, L.S. Osborne, M. Loreti, J. A. Jaros, John Scott Whitaker, J. Quigley, D. Aston, R. A. Johnson, A. Santocchia, T. Takahashi, L. Rosenson, F. E. Taylor, D. Calloway, Stephen Robert Wagner, B. N. Ratcliff, C. Simopoulos, M.E. Huffer, J. R. Bogart, P. E. Stamer, C. Fan, T.J. Pavel, R. Frey, S. De Simone, F. Perrier, G. B. Chadwick, J. R. Johnson, R. Kajikawa, P. D. Acton, P. C. Kim, I. M. Peruzzi, R. E. Cassell, P.E. Rensing, R. Cowan, A. Bean, Yeong-Dae Kwon, A. P. Waite, K.G. Baird, B. Mours, David A. Williams, A. K. McKemey, B. A. Schumm, J. D. Turk, S. Manly, H. A. Neal, Richard Dubois, Michele Gallinaro, R. W. Zdarko, M.E. King, R. Messner, E. Vella, J. Huber, M. Petradza, M. Turcotte, R. Ben-David, J. Zhou, M. Woods, Rino Castaldi, H. O. Cohn, G. D. Punkar, M. Tecchio, R. J. Morrison, L. Pescara, D. C. Williams, Martin Breidenbach, C. Y. Prescott, D. Su, E. Mazzuícato, M. Piccolo, and K. Hasegawa
Subjects: Coupling constant, Physics, Quantum chromodynamics, Statistics::Theory, Particle physics, Statistics::Applications, 010308 nuclear & particles physics, Computer Science::Information Retrieval, Electron–positron annihilation, Hadron, General Physics and Astronomy, Elementary particle, Coupling (probability), 01 natural sciences, Standard Model, Nuclear physics, Particle decay, 0103 physical sciences, Order (group theory), High Energy Physics::Experiment, Perturbation theory, 010306 general physics, Energy (signal processing), Boson
Abstract: We determine the strong coupling ${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}$ from a comprehensive study of energy-energy correlations (EEC's) and their asymmetry (AEEC's) in hadronic decays of ${\mathit{Z}}^{0}$ bosons collected by the SLD experiment at SLAC. The data are compared with all four available predictions of QCD calculated up to O(${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}^{2}$) in perturbation theory, and also with a resummed calculation matched to all four of these calculations. We find large discrepancies between ${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}$ values extracted from the different O(${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}^{2}$) calculations. We also find a large renormalization scale ambiguity in ${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}$ determined from the EEC's using the O(${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}^{2}$) calculations; this ambiguity is reduced in the case of the AEEC's and is very small when the matched calculations are used. Averaging over all calculations, and over the EEC and AEEC results, we obtain ${\mathrm{\ensuremath{\alpha}}}_{\mathit{s}}$(${\mathit{M}}_{\mathit{Z}}^{2}$)=0.${124}_{\mathrm{\ensuremath{-}}0.004}^{+0.003}$ (expt.) \ifmmode\pm\else\textpm\fi{}0.009 (theory).
Published: 1994
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44. Precise Measurement of the Left-Right Cross Section Asymmetry inZBoson Production bye+e−Collisions

Author: R. E. Cassell, P.E. Rensing, T. H. Burnett, C. C. Young, R. Cowan, M. Nussbaum, R. Kajikawa, S. J. Yellin, G. H. Zapalac, S. Sen, L. S. Osborne, Y. Hasegawa, J.P. Venuti, Roberto Dell'Orso, N.M. Krishna, J. Va'vra, C.J.S. Damerell, G. M. Bilei, G. R. Bower, R. Ben-David, James Shank, Andrea Castro, J. Ma, H. L. Lynch, S. Hedges, J. Rothberg, I. Abt, J. Zhou, G. B. Word, R. King, A. P. Waite, J. Duboscq, M. Swartz, A. S. Johnson, C. Y. Prescott, O. Bardon, C. Baltay, M. Carpinelli, H. Masuda, C. Fan, T.J. Pavel, P. C. Rowson, H. Yuta, U. Nauenberg, B. A. Schumm, R. Frey, S. De Simone, T. Maruyama, R. Steiner, D. Su, T. Schalk, Wit Busza, S. Gonzalez, T. Gillman, F. J. Decker, J. Huber, J. R. Johnson, B. Camanzi, Shinzo Suzuki, M. Piccolo, M. Langston, O. H. Saxton, G. Mancinelli, H. R. Band, David O. Caldwell, E. Torrence, H. A. Neal, P. N. Burrows, R. Prepost, J. Wyss, Dario Bisello, T. Nagamine, T. Bienz, R. K. Yamamoto, R. Cotton, P.F. Jacques, L. Pescara, X. Liu, D.C. Schultz, P. Emma, S. S. Hertzbach, J. Quigley, J. D. Turk, J. J. Russell, Y. C. Du, T. Takahashi, K. Furuno, A. Sugiyama, R. S. Panvini, Fred Wickens, C. Zeitlin, A. Seiden, D. Aston, Stephen Robert Wagner, Y. Iwasaki, T. L. Usher, Henry W. Kendall, J. S. Whitaker, D. Calloway, T. Limberg, R. A. Johnson, R. Messner, D. G. Coyne, R. Castaldi, H. Park, E. Church, J. A. Lauber, T. Junk, Alberto Benvenuti, U. Schneekloth, B. Mours, L. S. Rochester, H. Kawahara, E. Vella, J. E. Brau, A. Calcaterra, M. D. Hildreth, D. C. Williams, G. Muller, H. M. Steiner, F. Suekane, Brian Meadows, R. R. Kofler, D. J. Sherden, Stephen Watts, D. W. G. S. Leith, I. M. Peruzzi, E. W. Hughes, S. H. Williams, E. L. Garwin, Martin Breidenbach, S. Dasu, M. Kalelkar, Rafe Schindler, M.B. Barakat, W. J. Wisniewski, Robert Wilson, R.D. Elia, G. E. Gladding, J. A. Coller, K. T. Pitts, V. Cook, R. de Sangro, H. O. Cohn, G. Hallewell, J. R. Bogart, G. D. Punkar, R.J. Plano, S. Manly, J. M. Yamartino, M. Woods, R. W. Zdarko, M.E. King, J. A. Snyder, R. Dubois, P. Stamer, J. F. McGowan, A. Lath, Yeong-Dae Kwon, T. Barklow, M. H. Kelsey, K.G. Baird, David A. Williams, A. K. McKemey, G. Blaylock, S. Willocq, W. W. Ash, Michael Sokoloff, Joseph Izen, T. Bolton, Gilbert Shapiro, E. L. Hart, S. R. Smith, T. W. Reeves, Koji Abe, Nicola Bacchetta, Thomas W. Markiewicz, Piero Giorgio Verdini, Giancarlo Mantovani, G. Baranko, H. Hwang, D. G. Hitlin, E. Mazzucato, S. L. White, A.B. d'Oliveira, C. Simopoulos, F. E. Taylor, A. Lu, M. G. Strauss, L. Piemontese, Enrico Pieroni, J. F. Labs, M. E. Huffer, A. O. Bazarko, M. Cavalli-Sforza, B. N. Ratcliff, D. L. Burke, W. M. Bugg, P. De Simone, Michael H. Shaevitz, M. Loreti, K.C. Moffeit, R. S. Kroeger, A. W. Weidemann, J. A. Jaros, P. M. Mockett, I. Karliner, Dominik Müller, B. I. Eisenstein, A. Szumilo, M. J. Fero, and C. Vannini
Subjects: Physics, Particle physics, Cabibbo–Kobayashi–Maskawa matrix, media_common.quotation_subject, Electron–positron annihilation, Hadron, General Physics and Astronomy, Elementary particle, Weinberg angle, Asymmetry, Nuclear physics, Particle decay, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, media_common, Boson
Abstract: We present a precise measurement of the left-right cross section asymmetry ([ital A][sub [ital L][ital R]]) for [ital Z] boson production by [ital e][sup +][ital e][sup [minus]] collisions. The measurement was performed at a center-of-mass energy of 91.26 GeV with the SLD detector at the SLAC Linear Collider (SLC). The luminosity-weighted average polarization of the SLC electron beam was (63.0[plus minus]1.1)%. Using a sample of 49 392 [ital Z] decays, we measure [ital A][sub [ital L][ital R]] to be 0.1628[plus minus]0.0071(stat)[plus minus]0.0028(syst) which determines the effective weak mixing angle to be sin[sup 2][theta][sub [ital W]][sup eff]=0.2292[plus minus]0.0009(stat) [plus minus]0.0004(syst).
Published: 1994
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45. Measurement of the charged multiplicity ofZ0→bb¯ events

Author: Amitabh Lath, M. Tecchio, L. Pescara, G. Muller, J. D. Turk, R. R. Kofler, Stephen Watts, J. Huber, M. Turcotte, Philip Burrows, Rino Castaldi, H. O. Cohn, G. D. Punkar, R. Prepost, S. McHugh, J. M. Yamartino, Roberto Battiston, J. Wyss, P. De Simone, B. Farhat, W. A. Majid, M. Langston, J. E. Brau, A. Calcaterra, M. Loreti, John Scott Whitaker, D. J. Mellor, P.Y.C. Du, H. A. Neal, E. Erdos, P.F. Jacques, P. C. Rowson, J. A. Coller, C. Zeitlin, O. Bardon, M.B. Barakat, H. Yuta, Michael S. Witherell, R.D. Elia, C. Fan, T.J. Pavel, R. Frey, Richard Dubois, S. De Simone, P. Saez, F. Perrier, G. E. Gladding, K. T. Pitts, L. Servoli, Melody A. Swartz, K.C. Moffeit, Joseph Izen, Elliot Hughes, S. H. Williams, T. W. Reeves, Koji Abe, A. Bean, N. Toge, G. M. Bilei, G. R. Bower, M. Kalelkar, J. R. Johnson, James Shank, R. Kajikawa, W. J. Wisniewski, Andrea Castro, A. Gillman, A. Lu, M. D. Hildreth, O. H. Saxton, J. A. Lauber, S. J. Yellin, P. Zucchelli, H. R. Band, L. Piemontese, S. Sen, Maurizio Biasini, B. Mours, N.M. Krishna, R. Shypit, D. J. Sherden, Fred Wickens, Enrico Pieroni, V. Cook, D. W. G. S. Leith, R. de Sangro, S. Manly, A. W. Weidemann, Thomas W. Markiewicz, T. Hansl-Kozanecka, R. Ben-David, J. Zhou, J. F. Labs, G. Hallewell, A. P. Waite, M. Woods, A. S. Johnson, A. Seiden, Sridhara Dasu, I. Stockdale, T. Bolton, C. Baltay, H. Masuda, D.C. Schultz, C. C. Young, J. Quigley, S. L. Shapiro, T. Takahashi, M. Zolotorev, R. Steiner, S. Gonzalez, S. Rousakov, B. N. Ratcliff, Gilbert Shapiro, A. K. Honma, D. Aston, B. A. Schumm, X. Liu, R. Verdier, E. L. Hart, Michele Gallinaro, R. W. Zdarko, C. Simopoulos, J. Duboscq, S. S. Hertzbach, Alberto Benvenuti, Roberto Dell'Orso, D. Calloway, Wit Busza, M.E. King, H. Kawahara, P. E. Stamer, G. H. Zapalac, S. Willocq, T. Maruyama, G. B. Word, Henry W. Kendall, C. Vannini, H. M. Steiner, R. King, Shiro Suzuki, R. S. Panvini, R. E. Cassell, P.E. Rensing, M. Carpinelli, J. Rothberg, I. Abt, K. Furuno, L. Rosenson, L. Chen, B. I. Eisentein, R. Cowan, Yukio Hasegawa, J. J. Thaler, R. Claus, R. K. Yamamoto, D. G. Coyne, S. Smith, Yeong-Dae Kwon, W. W. Ash, G. Blaylock, B. Camanzi, R. Cotton, S. Hedges, K.G. Baird, R. J. Belcinski, David A. Williams, A. K. McKemey, U. Schneekloth, F. Suekane, R. Messner, E. Vella, M. Petradza, H. L. Lynch, P. M. Mockett, I. Karliner, M. G. Strauss, Dominik Müller, R. H. Schindler, A. Szumilo, R. Kroeger, Hyun-Chul Kim, J. A. Snyder, M. H. Kelsey, G. Mancinelli, E. Church, T. Junk, M. Nussbaum, E. Torrence, R.J. Plano, A. O. Bazarko, Piero Giorgio Verdini, J. Ma, M. Pauluzzi, P. Coyle, L.S. Rochester, J. D. Richman, Y. Iwasaki, T. L. Usher, H. Park, Giancarlo Mantovani, H. Hwang, U. Nauenberg, D. G. Hitlin, Dario Bisello, I. M. Peruzzi, E. Mazzucato, J. Va’vra, J. Carr, D. L. Burke, W. M. Bugg, T. Nagamine, Nicola Bacchetta, D. O. Caldwell, T. Schalk, G. Baranko, D. C. Williams, S. L. White, A.B. d'Oliveira, T. Bienz, J. J. Russell, L.S. Osborne, R. A. Johnson, Martin Breidenbach, J.P. Venuti, C.J.S. Damerell, R. J. Wilson, C. Y. Prescott, D. Su, M. Piccolo, K. Hasegawa, J. F. McGowan, A. Sugiyama, F. E. Taylor, M.E. Huffer, J. R. Bogart, G. B. Chadwick, Michael J. Fero, J.I. Friedman, M. Cavalli-Sforza, B. T. Meadows, M. D. Sokoloff, M. H. Shaevitz, and T. H. Burnett
Subjects: Physics, Combinatorics, General Physics and Astronomy, Multiplicity (mathematics)
Abstract: Using an impact parameter tag to select an enriched sample of [ital Z][sup 0][r arrow][ital b[bar b]] events, we have measured the difference between the average charged multiplicity of [ital Z][sup 0][r arrow][ital b[bar b]] and [ital Z][sup 0][r arrow] hadrons to be [ital [bar n]][sub [ital b]][minus][ital [bar n]][sub had]=2.24[plus minus]0.30 ( stat )[plus minus]0.33 ( syst ) tracks per event. From this, we have derived [ital [bar n]][sub [ital b]][minus][ital [bar n]][sub [ital u][ital d][ital s]]=3.31[plus minus]0.41[plus minus]0.79. Comparing this measurement with those at lower center-of-mass energies, we find no evidence that [ital [bar n]][sub [ital b]][minus][ital [bar n]][sub [ital u][ital d][ital s]] depends on energy. This result is in agreement with a precise prediction of perturbative QCD, and supports the notion that QCD remains asymptotically free down to the scale [ital M][sub [ital b]][sup 2].
Published: 1994
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46. Pollution atmosphérique et diabète… Quel lien possible ? Une exposition expérimentale à l’ozone chez le rat induit une insulino-résistance périphérique

Author: E. VELLA, Roxane, primary, GÉLOËN, Alain, additional, and O. SOULAGE, Christophe, additional
Published: 2016
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47. The lead-liquid argon sampling calorimeter of the SLD detector

Author: A. O. Bazarko, M. Foss, D. Arnett, C. G. Arroyo, D. P. Gurd, D. A. Forbush, A. P. Waite, M. Turcotte, E. Hyatt, L. Camilleri, A. I. Mincer, Rafe Schindler, S.C. Bes, R. Davis, F. De Jongh, J. Harrison, B. Bugg, J. F. Labs, M. E. Huffer, S. Manly, W. Wisniewski, Ma Ji, G. R. Mason, G. A. Beer, D. Sherden, Michael H. Shaevitz, P. Seward, S. Seligman, A. Astbury, F. Barrera, P. Poffenberger, V. Cook, R. Claus, Martin Breidenbach, Peter S. Kim, A. W. Weidemann, T. Bolton, Y. Au, C. Baltay, D. G. Hitlin, C. J. Oram, J. Hodgson, R. C. Wolf, R. Bell, M. Klein, M. J. Fox, Gunther Haller, S.R. Smith, V. Hamilton, R. Watt, T. Junk, S. Bougerolle, J. R. Bogart, M. Nordby, L. Paffrath, R. Sobie, R. Dubois, P. M. Mockett, Richard Keeler, A. Gioumousis, John Fox, P. Saez, R.V. Steiner, Howard Rogers, M. H. Kelsey, D. F. Alzofon, A. Candia, P. Schenk, H. Kim, E. Vella, H. A. Neal, J. E. Brau, T. A. Hodges, Graham L. W. Cross, D. Axen, G. Putallaz, A. Grebenyuk, J. J. Russell, I. Abt, D. Nelson, A.S. Turcot, H. Cutler, F. Toevs, A. K. Honma, L. P. Robertson, R. Langstaff, S.A. Rabinowitz, G. Eigen, P. C. Rowson, and K. Skarpaas
Subjects: Cryostat, Physics, Nuclear and High Energy Physics, Argon, Physics::Instrumentation and Detectors, Nuclear engineering, Detector, chemistry.chemical_element, Cryogenics, Particle detector, Calorimeter, Data acquisition, chemistry, Measuring instrument, High Energy Physics::Experiment, Instrumentation
Abstract: The lead-liquid argon sampling calorimeter of the SLD detector is one of the largest detectors employing cryogenic liquids now in operation. This paper details the design and performance considerations, the mechanical and cryogenic systems, the absorber design and tower segmentation, the data acquisition electronics, and the control systems of the detector. The initial operational performance of the device is discussed. Detailed resolution studies will be presented in a later paper.
Published: 1993
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48. First measurement of the left-right cross section asymmetry inZboson production bye+e−collisions

Author: J. Duboscq, Tadayuki Takahashi, S. Bethke, W. T. Emmet, R. Dolin, R. King, J. Hodgson, Sridhara Dasu, G.J. Tappern, S. A. Wickert, P. C. Rowson, R. J. Stephenson, R. Prepost, D. Pripstein, M. Tecchio, J. E. Brau, A. W. Weidemann, A. Yim, P.F. Jacques, T. Dean, T. H. Burnett, Amitabh Lath, H. Yuta, L. Piemontese, B. F. Wadsworth, Enrico Pieroni, E. Hyatt, L. Mathys, R. H. Schindler, A. Szumilo, G. Tarnopolsky, M. Settles, Roberto Battiston, R. Davis, A. Nuttall, T. A. Hodges, R. R. Kofler, D. Walz, A. V. Kulikov, R. Messner, J. F. Labs, J.P. Venuti, P. E.L. Clarke, A. Rothenberg, D. Mansour, R. Kroeger, D. Axen, A. Gioumousis, W. A. Majid, H. J. Hargis, C.J.S. Damerell, R. J. Wilson, D. J. Sherden, A. K. Honma, E. Vella, A. I. Mincer, S. H. Williams, A. O. Bazarko, D. D. Durrett, O. Chamberlain, J. A. Coller, E. L. Garwin, John Fox, N. Toge, D. Horelick, C. Baltay, M. D. Hildreth, F. Bird, C. Y. Prescott, D. W. G. S. Leith, P. Coyle, H. Cutler, C. J. Oram, H. Masuda, H. L. Lynch, R. Bell, J. Olsen, Nicholas Walker, J. Escalera, A.P.T. Palounek, Roberto Dell'Orso, L. P. Robertson, Melody A. Swartz, D. Su, D. Warner, R. R. Larsen, H. Petersen, J. Clendenin, A. Astbury, R. J. Morrison, G. A. Beer, D. R. Freytag, R. H. Siemann, Philip Burrows, T. Hansl-Kozanecka, S. McHugh, A. L. Shoup, R. E. Cassell, P.E. Rensing, T. Shimomura, M. Piccolo, M. J. Fox, J. Rothberg, D.C. Schultz, R. Langstaff, I. Abt, L. Pescara, I. Stockdale, G. Stewart, H. Shaw, P. De Simone, J. M. Yamartino, D. J. Mellor, M. Langston, O. Bardon, R.L. English, R. Watt, V. Cook, R. Cotton, M. Petradza, P. M. Mockett, V. Ashford, P. Saez, Michael S. Witherell, R. de Sangro, K. Skarpaas, R. C. Hilomen, T. Fieguth, Wit Busza, J. Flynn, D. Aston, G. Mancinelli, Patrick Krejcik, R. Rinta, T. W. Reeves, Rino Castaldi, H. O. Cohn, M. Loreti, V. Ziemann, K. Hasegawa, Richard Keeler, S. Kaiser, S. Hedges, J. L. Turner, G. Agnew, Joseph Izen, B. Burgess, L. Servoli, R. J. Belcinski, K. K. Young, John Scott Whitaker, X. Liu, Koji Abe, P. Kunz, S. S. Hertzbach, W. Craddock, G. Hallewell, I. Karliner, M. G. Strauss, Dominik Müller, J. Carr, D. Calloway, A. Lu, C. C. Young, B. I. Eisenstein, Elliot Hughes, T. Junk, M. Carpinelli, S. Bougerolle, G. D. Punkar, J. D. Turk, D. L. Burke, H. O. Ogren, R. W. Williams, W. M. Bugg, U. Schneekloth, S.C. Berridge, A. Disco, D. L. Hale, G. M. Bilei, G. R. Bower, James Shank, R. Cowan, Andrea Castro, Henry W. Kendall, L. Chen, R. K. Jobe, R. Ossa, Gunther Haller, O. H. Saxton, E. Rutz, C. Alber, T. Schalk, F. Toevs, J. J. Thaler, R. Claus, J. Fujimoto, D. P. Gurd, R. K. Yamamoto, P. Stiles, M. Minty, B. N. Ratcliff, S. Ecklund, D. Chambers, J. Wyss, C. Simopoulos, H. R. Band, J. A. Lauber, A. Santocchia, C. Yee, E. Erdos, P. Poffenberger, Yeong-Dae Kwon, G. Blaylock, D. A. Forbush, J. Huber, D. Kharakh, B. Camanzi, W. W. Ash, W. J. Wisniewski, F. Suekane, R.J. Plano, P. E. Stamer, M. Schneider, G. Eigen, M. Turcotte, M. D. Woodly, P. Zucchelli, G. Putallaz, M. J. Haney, A. Bean, C. G. Arroyo, B.L. Byers, W. Baker, W. L. Spence, S.R. Smith, Fred Wickens, A. P. Waite, J. T. Seeman, C. Zeitlin, T. Lyons, T. Bienz, N. Phinney, Martin Breidenbach, S. J. Yellin, L. Lintern, L. Paffrath, A. Calcaterra, K.G. Baird, R. Berger, C. Jako, N.M. Krishna, R.D. Elia, G. E. Gladding, S. Manly, I. M. Peruzzi, E. Mazzucato, R. Pitthan, Hyun-Chul Kim, J. J. Russell, Y. C. Du, W. Dunwoodie, David A. Williams, Y. Au, A. K. McKemey, R. F. Boyce, M. Zolotorev, J. A. Snyder, K. T. Pitts, L.S. Osborne, G. H. Zapalac, H. Tang, A. S. Johnson, M. Kalelkar, J. Frisch, R. S. Panvini, J. Hoeflich, T. Maruyama, B. A. Schumm, K.C. Moffeit, G. B. Word, G. E. Schultz, R. A. Johnson, R. Steiner, P. Antilogus, M. H. Kelsey, J. C. Sheppard, S. Gonzalez, M. Gaillard, A. Snyder, Thomas W. Markiewicz, S. L. Cartwright, K. Furuno, A. D. Yeremian, T. Gillman, V. Nesterov, H.J. Kang, Maurizio Biasini, T. Himel, Marc Ross, Yukio Hasegawa, H. A. Neal, Shiro Suzuki, D. F. Alzofon, Michele Gallinaro, D. Cords, M. Kowitt, A.K.S. Santha, R. W. Zdarko, D. G. Coyne, D. C. Williams, T. Bolton, C. Vannini, G. Oxoby, R. Shypit, Gilbert Shapiro, R. Verdier, E. L. Hart, D. Peters, A. Seiden, R. W. Downing, M. Z. Tahar, P. J. Emma, Alberto Benvenuti, H. Kawahara, C. Fan, T.J. Pavel, R. Frey, S. De Simone, F. Perrier, J. R. Johnson, R. Kajikawa, G. Mundy, V. Hamilton, P. D. Acton, P. C. Kim, H. M. Steiner, L. Rosenson, P. Schenk, K. M. Fortune, Richard Dubois, R. Ben-David, J. Zhou, M. Woods, J. Va’vra, M. Nordby, T. E. Browder, B. Mours, T. Nagamine, Nicola Bacchetta, D. McCormick, D. O. Caldwell, J. F. McGowan, G. Mazaheri, A. Sugiyama, M. Nussbaum, G. Mueller, Stephen Watts, F. Barrera, S. Jones, F. E. Taylor, M.E. Huffer, J. R. Bogart, J. Ferrie, R. Sobie, A. Mazzucato, Piero Giorgio Verdini, M. Pauluzzi, J. Ma, L. Camilleri, J. D. Richman, G. B. Chadwick, T. Weber, Giancarlo Mantovani, H. Hwang, Michael J. Fero, S.St. Lorant, J.I. Friedman, L.S. Rochester, Y. Iwasaki, T. L. Usher, M. Cavalli-Sforza, B. T. Meadows, D. G. Hitlin, F. J. Decker, M. D. Sokoloff, E.N. Spencer, H. Park, M. H. Shaevitz, G. Baranko, T. Limberg, D. R. Rust, G. R. Mason, S. L. White, D. Nelson, P. Raimondi, S. L. Shapiro, P. Rankin, A.B. d'Oliveira, U. Nauenberg, J. Harrison, Chris Adolphsen, R. Blumberg, F. Dejongh, Dario Bisello, and M. Klein
Subjects: Physics, Particle physics, Cabibbo–Kobayashi–Maskawa matrix, media_common.quotation_subject, General Physics and Astronomy, Elementary particle, Production (computer science), Beam polarization, Asymmetry, Energy (signal processing), media_common, Standard Model, Boson
Abstract: We present the first measurement of the left-right cross section asymmetry (${\mathit{A}}_{\mathit{L}\mathit{R}}$) for Z boson production by ${\mathit{e}}^{+}$${\mathit{e}}^{\mathrm{\ensuremath{-}}}$ collisions. The measurement was performed at a center-of-mass energy of 91.55 GeV with the SLD detector at the SLAC Linear Collider which utilized a longitudinally polarized electron beam. The average beam polarization was (22.4\ifmmode\pm\else\textpm\fi{}0.6)%. Using a sample of 10 224 Z decays, we measure ${\mathit{A}}_{\mathit{L}\mathit{R}}$ to be 0.100\ifmmode\pm\else\textpm\fi{}0.044(stat)\ifmmode\pm\else\textpm\fi{}0.004(syst), which determines the effective weak mixing angle to be ${\mathrm{sin}}^{2}$${\mathrm{\ensuremath{\theta}}}_{\mathit{W}}^{\mathit{e}\mathit{f}\mathit{f}}$=0.2378 \ifmmode\pm\else\textpm\fi{}0.0056(stat)\ifmmode\pm\else\textpm\fi{}0.0005(syst).
Published: 1993
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49. Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells

Author: Roxane E. Vella, Marine L. Croze, Michel Lagarde, Laurent Soulère, Bertrand R. Caré, Christophe O. Soulage, Hédi Soula, Alain Doutheau, Nicolas J. Pillon, Régulations métaboliques, nutrition et diabètes - UM55 (RMND UM55), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Organique (LCO), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), Artificial Evolution and Computational Biology (BEAGLE), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), INSERM, INSA-Lyon, French 'Ministere de l'Education Nationale, de la Recherche et de la Technologie', Region Rhone-Alpes, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)
Subjects: END-PRODUCTS, Stereochemistry, DNA damage, Protein Carbonylation, Lipid peroxidation, INCREASED OXIDATIVE STRESS, Quantitative Structure-Activity Relationship, Apoptosis, Alkenes, Toxicology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 4-Hydroxy-2-hexenal, QSTR, 0302 clinical medicine, medicine, Animals, OXIDIZED PHOSPHOLIPIDS, Viability assay, Cells, Cultured, 030304 developmental biology, POLYUNSATURATED FATTY-ACIDS, 0303 health sciences, Aldehydes, INSULIN-RESISTANCE, Nucleophilic addition, RAT HEPATOCYTES, L-Lactate Dehydrogenase, Caspase 3, Muscles, Acetal, EPITHELIAL-CELLS, General Medicine, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], LIPID-PEROXIDATION PRODUCT, Rats, chemistry, Biochemistry, HYDROXY-ALKENALS, DNA-DAMAGE, Covalent bond, Oxidative stress, 4-Hydroxy-2-nonenal, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], 030217 neurology & neurosurgery
Abstract: International audience; Lipid peroxidation is one of the most important sources of endogenous toxic metabolites. 4-Hydroxy-2-nonenal (HNE) and 4-hydroxy-2-hexenal (HHE) are produced in several oxidative stress associated diseases from peroxidation of n-6 and n-3 polyunsaturated fatty acids, respectively. Both are able to form covalent adducts with many biomolecules. Particularly, proteins adduction can induce structural and conformational changes and impair biological function, which may be involved in the toxicity of hydroxy-alkenals. The aim of this study was to compare the effect of 4-hydroxy-2-alkenals to several chemically related derivatives in order to clarify the physico-chemical requirement of their toxicity. L6 muscle cells were treated with HHE, HNE and parent derivatives (acetal derivative, trans-alkenals and alkanals). Viability and necrosis were estimated using MTT, LDH and caspase-3 tests. LogLC50 (Lethal Concentration 50) was then tested for correlation with adducts formation (estimated using dinitrophenylhydrazine) and several molecular descriptors in order to establish quantitative structure-toxicity relationship (QSTR) models. The rank of derivatives toxicity, based on LC50 was: hydroxy-alkenals>acetal derivatives approximately 2-alkenals>alkanals and a high correlation was found between logLC50 and protein carbonylation. Moreover, logLC50 was correlated to the electrophilic descriptor LUMO (lowest unoccupied molecular orbital) as well as with electronegativity-related molecular descriptors such as number of oxygen atoms, partial negative surface area (PNSA3) and partial positive surface area (PPSA3). Together, these results point out the important role of the electrophilic structure and adduct formation in hydroxy-alkenals toxicity. Our present study demonstrates that 4-hydroxy-2-alkenals dramatic effects on cell viability are due to covalent adducts formation, particularly Michael adducts. This capacity is related to the electrophilic structure and reactive CC double bond, making it highly accessible for nucleophilic addition. The present study suggests that nucleophilic scavengers might protect cells against electrophile compounds and might be of possible therapeutic value in oxidative stress associated diseases.
Published: 2010
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50. Bilateral inferior insertion of lateral rectus muscles associated with schizencephaly

Author: Nick Saad, Meaghan E Vella, and Steven B Wine
Subjects: Male, genetic structures, business.industry, Brain, Septo-optic dysplasia, Anatomy, medicine.disease, Extraocular muscles, eye diseases, Anomalous extraocular muscles, Ophthalmology, medicine.anatomical_structure, Schizencephaly, Oculomotor Muscles, Left hemiparesis, Child, Preschool, medicine, Exotropia, Humans, Eye Abnormalities, sense organs, Tomography, X-Ray Computed, business
Abstract: A 5-year-old boy with a large V-pattern exotropia is described. He has a background of congenital left hemiparesis associated with schizencephaly. At the time of surgery the lateral recti were found to be abnormally inferiorly positioned. Accordingly, both lateral rectus muscles were recessed 6.5 mm and supraplaced. A V-pattern exotropia persisted postoperatively with clinical overaction of the inferior obliques. To our knowledge this is the first known case of extraocular muscle abnormalities associated with schizencephaly.
Published: 2000
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