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2. Accounting for retarded weathering products in comparing methods for quantifying carbon dioxide removal in a short-term enhanced weathering study

Author

Emily E. E. M. te Pas, Elliot Chang, Alison R. Marklein, Rob N. J. Comans, and Mathilde Hagens

Subjects
enhanced weathering, soil-based mass balances, leachate-based total alkalinity, olivine, wollastonite, albite, Environmental sciences, GE1-350
Abstract

Various approaches are currently used to quantify the carbon dioxide removal (CDR) associated with enhanced weathering (EW), which involves amending soils with crushed silicate minerals. We aimed to contribute to the development of a standardized procedure for CDR quantification by complementing the results of a recently published soil column experiment, in which crushed olivine, wollastonite, and albite were added to soils, with total fusion ICP-OES analyses of base cation concentrations. CDR quantified by soil-based mass balance approaches was only comparable to leachate-based total alkalinity measurements after correcting for the weathering products that were retained within the soil profile, which we defined as the retarded fraction. The retarded fraction comprised 92.7–98.3% of the weathered cations, indicating that at least in our short-term study (64 days), the majority of weathering products were retained within the soil. Further investigation of the fate of retarded weathering products showed that small portions precipitated as carbonate minerals (up to 34.0%) or adsorbed to reactive surfaces, such as soil organic matter and clay minerals (up to 32.5%). Hence, a large portion of weathering products may be retained in the soil due to strong adsorption and/or further mineral precipitation reactions (31.6–92.7%), with potentially important implications for the quantification of CDR across time. We conclude that soil-based mass balance approaches are useful in quantifying weathering rates and can infer potential CDR; however, the actual CDR realized for a given time and depth interval can only be constrained after accounting for the retarded fraction.

Published
2025
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3. First release of Apertif imaging survey data

Author

Adams, Elizabeth A. K., Adebahr, B., de Blok, W. J. G., Denes, H., Hess, K. M., van der Hulst, J. M., Kutkin, A., Lucero, D. M., Morganti, R., Moss, V. A., Oosterloo, T. A., Orru, E., Schulz, R., van Amesfoort, A. S., Berger, A., Boersma, O. M., Bouwhuis, M., Brink, R. van den, van Cappellen, W. A., Connor, L., Coolen, A. H. W. M., Damstra, S., van Diepen, G. N. J., Dijkema, T. J., Ebbendorf, N., Grange, Y. G., de Goei, R., Gunst, A. W., Holties, H. A., Hut, B., Ivashina, M. V., Jozsa, G. I. G., Loose, G. M., van Leeuwen, J., Maan, Y., Mancini, M., Mika, A., Mulder, H., Norden, M. J., Offringa, A. R., Oostrum, L. C., Pastor-Marazuela, I., Pisano, D. J., Ponomareva, A. A., Romein, J. W., Ruiter, M, Schoenmakers, A. P., van der Schuur, D., Sluman, J. J., Smits, R., Stuurwold, K. J. C, Verstappen, J., Vilchez, N. P. E, Vohl, D., Wierenga, K. J., Wijnholds, S. J., Woestenburg, E. E. M., Zanting, A. W., and Ziemke, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

(Abridged) Apertif is a phased-array feed system for WSRT, providing forty instantaneous beams over 300 MHz of bandwidth. A dedicated survey program started on 1 July 2019, with the last observations taken on 28 February 2022. We describe the release of data products from the first year of survey operations, through 30 June 2020. We focus on defining quality control metrics for the processed data products. The Apertif imaging pipeline, Apercal, automatically produces non-primary beam corrected continuum images, polarization images and cubes, and uncleaned spectral line and dirty beam cubes for each beam of an Apertif imaging observation. For this release, processed data products are considered on a beam-by-beam basis within an observation. We validate the continuum images by using metrics that identify deviations from Gaussian noise in the residual images. If the continuum image passes validation, we release all processed data products for a given beam. We apply further validation to the polarization and line data products. We release all raw observational data from the first year of survey observations, for a total of 221 observations of 160 independent target fields, covering approximately one thousand square degrees of sky. Images and cubes are released on a per beam basis, and 3374 beams are released. The median noise in the continuum images is 41.4 uJy/bm, with a slightly lower median noise of 36.9 uJy/bm in the Stokes V polarization image. The median angular resolution is 11.6"/sin(Dec). The median noise for all line cubes, with a spectral resolution of 36.6 kHz, is 1.6 mJy/bm, corresponding to a 3-sigma HI column density sensitivity of 1.8 x 10^20 atoms cm^-2 over 20 km/s (for a median angular resolution of 24" x 15"). We also provide primary beam images for each individual Apertif compound beam. The data are made accessible using a Virtual Observatory interface., Comment: Accepted for publication in A&A, updated Figure 1

Published
2022
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4. Performance evaluation of MeteoTracker mobile sensor for outdoor applications

Author

F. Barbano, E. Brattich, C. Cintolesi, A. Ghafoor Nizamani, S. Di Sabatino, M. Milelli, E. E. M. Peerlings, S. Polder, G.-J. Steeneveld, and A. Parodi

Subjects
Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract

The morphological complexity of urban environments results in a high spatial and temporal variability of the urban microclimate. The consequent demand for high-resolution atmospheric data remains a challenge for atmospheric research and operational application. The recent widespread availability and increasing adoption of low-cost mobile sensing offer the opportunity to integrate observations from conventional monitoring networks with microclimatic and air pollution data at a finer spatial and temporal scale. So far, the relatively low quality of the measurements and outdoor performance compared to conventional instrumentation has discouraged the full deployment of mobile sensors for routine monitoring. The present study addresses the performance of a commercial mobile sensor, the MeteoTracker (IoTopon Srl), recently launched on the market to quantify the microclimatic characteristics of the outdoor environment. The sensor follows the philosophy of the Internet of Things technology, being low cost, having an automatic data flow via personal smartphones and online data sharing, supporting user-friendly software, and having the potential to be deployed in large quantities. In this paper, the outdoor performance is evaluated through tests aimed at quantifying (i) the intra-sensor variability under similar atmospheric conditions and (ii) the outdoor accuracy compared to a reference weather station under sub-optimal (in a fixed location) and optimal (mobile) sensor usage. Data-driven corrections are developed and successfully applied to improve the MeteoTracker data quality. In particular, a recursive method for the simultaneous improvement of relative humidity, dew point, and humidex index proves to be crucial for increasing the data quality. The results mark an intra-sensor variability of approximately ± 0.5 °C for air temperature and ± 1.2 % for the corrected relative humidity, both of which are within the declared sensor accuracy. The sensor captures the same atmospheric variability as the reference sensor during both fixed and mobile tests, showing positive biases (overestimation) for both variables. Through the mobile test, the outdoor accuracy is observed to be between ± 0.3 to ± 0.5 °C for air temperature and between ± 3 % and ± 5 % for the relative humidity, ranking the MeteoTracker in the real accuracy range of similar commercial sensors from the literature and making it a valid solution for atmospheric monitoring.

Published
2024

5. Open communication between patients and relatives about illness & death in advanced cancer—results of the eQuiPe Study

Author

Haaksman, Michelle, Ham, Laurien, Brom, Linda, Baars, Arnold, van Basten, Jean-Paul, van den Borne, Ben E. E. M., Hendriks, Mathijs P., de Jong, Wouter K., van Laarhoven, Hanneke W. M., van Lindert, Anne S. R., Mandigers, Caroline M. P. W., van der Padt-Pruijsten, Annemieke, Smilde, Tineke J., van Zuylen, Lia C., van Vliet, Liesbeth M., and Raijmakers, Natasja J. H.

Published
2024
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6. Apertif, Phased Array Feeds for the Westerbork Synthesis Radio Telescope

Author

van Cappellen, W. A., Oosterloo, T. A., Verheijen, M. A. W., Adams, E. A. K., Adebahr, B., Braun, R., Hess, K. M., Holties, H., van der Hulst, J. M., Hut, B., Kooistra, E., van Leeuwen, J., Loose, G. M., Morganti, R., Moss, V. A., Orrú, E., Ruiter, M., Schoenmakers, A. P., Vermaas, N. J., Wijnholds, S. J., van Amesfoort, A. S., Arts, M. J., Attema, J. J., Bakker, L., Bassa, C. G., Bast, J. E., Benthem, P., Beukema, R., Blaauw, R., de Blok, W. J. G., Bouwhuis, M., Brink, R. H. van den, Connor, L., Coolen, A. H. W. M., Damstra, S., van Diepen, G. N. J., de Goei, R., Dénes, H., Drost, M., Ebbendorf, N., Frank, B. S., Gardenier, D. W., Gerbers, M., Grange, Y. G., Grit, T., Gunst, A. W., Gupta, N., Ivashina, M. V., Józsa, G. I. G., Janssen, G. H., Koster, A., Kruithof, G. H., Kuindersma, S. J., Kutkin, A., Lucero, D. M., Maan, Y., Maccagni, F. M., van der Marel, J., Mika, A., Morawietz, J., Mulder, H., Mulder, E., Norden, M. J., Offringa, A. R., Oostrum, L. C., Overeem, R. E., Paragi, Z., Pepping, H. J., Petroff, E., Pisano, D. J., Polatidis, A. G., Prasad, P., de Reijer, J. P. R., Romein, J. W., Schaap, J., Schoonderbeek, G. W., Schulz, R., van der Schuur, D., Sclocco, A., Sluman, J. J., Smits, R., Stappers, B. W., Straal, S. M., Stuurwold, K. J. C., Verstappen, J., Vohl, D., Wierenga, K. J., Woestenburg, E. E. M., Zanting, A. W., and Ziemke, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe the APERture Tile In Focus (Apertif) system, a phased array feed (PAF) upgrade of the Westerbork Synthesis Radio Telescope which has transformed this telescope into a high-sensitivity, wide field-of-view L-band imaging and transient survey instrument. Using novel PAF technology, up to 40 partially overlapping beams can be formed on the sky simultaneously, significantly increasing the survey speed of the telescope. With this upgraded instrument, an imaging survey covering an area of 2300 deg2 is being performed which will deliver both continuum and spectral line data sets, of which the first data has been publicly released. In addition, a time domain transient and pulsar survey covering 15,000 deg2 is in progress. An overview of the Apertif science drivers, hardware and software of the upgraded telescope is presented, along with its key performance characteristics., Comment: 29 pages, 42 figures, accepted for publication by A&A

Published
2021
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7. Gender diversity and autism spectrum disorder in child and youth population

Author

P. R. Rodríguez, M. M. Grimal, E. E. M. Castellano, F. A. R. Batista, and N. M. Pérez

Subjects
Psychiatry, RC435-571
Abstract

Introduction Interest in the co-occurrence of gender dysphoria and autism spectrum disorder has gained prominence in recent years. Gender dysphoria refers to the distress experienced when there is an incongruence between gender identity and sex assigned at birth. On the other hand, autism spectrum disorder is characterized by difficulties in communication and social interaction, as well as restrictive and repetitive patterns of behavior. Objectives The aim of this paper is to review the current available literature in order to expand our knowledge about gender identity and dysphoria in the population with autism spectrum disorder. Methods A qualitative review was conducted over the last 20 years, using the Medline database through PubMed. Combinations of MeSH terms related to gender identity and people with autism spectrum disorder were used, selecting those studies in English, French or Spanish that met the objectives of the review, excluding references in other languages. The scientific evidence obtained was analyzed and synthesized. Results The development of gender identity of people with autism spectrum disorder can be a complex process. Comparing the general population with the population with autism spectrum disorder, a higher prevalence of gender dysphoria has been evidenced in the population with autism spectrum disorder, and within this group when segmented by gender, greater in women than in men. Conclusions This review highlights the importance of increasing knowledge about sexuality and gender dysphoria in people with autism spectrum disorder in order to facilitate the development, understanding and acceptance of their gender identity and sexual orientation of these people. Disclosure of Interest None Declared

Published
2024
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9. Mixed-Methods Exploration of Students' Motivation in Using Augmented Reality in Neuroanatomy Education with Prosected Specimens

Author

Bölek, Kerem A., De Jong, Guido, Van der Zee, Catharina E. E. M., Cappellen van Walsum, Anne-Marie, and Henssen, Dylan J. H. A.

Abstract

The use of augmented reality (AR) in teaching and studying neuroanatomy has been well researched. Previous research showed that AR-based learning of neuroanatomy has both alleviated cognitive load and was attractive to young learners. However, how the attractiveness of AR effects student motivation has not been discovered. Therefore, the motivational effects of AR were investigated in this research by the use of quantitative and qualitative methods. Motivation elicited by the GreyMapp-AR, an AR application, was investigated in medical and biomedical sciences students (n = 222; mean age: 19.7 ± 1.4 years) using the instructional measure of motivation survey (IMMS). Additional components (i.e., attention, relevance, confidence, and satisfaction) were also evaluated with motivation as measured by IMMS. Additionally, 19 students underwent audio-recorded individual interviews which were transcribed for qualitative analysis. Males regarded the relevance of AR significantly higher than females (P < 0.024). Appreciation of the GreyMapp-AR program was found to be significantly higher in students studying biomedical sciences as compared to students studying medicine (P < 0.011). Other components and scores did not show significant differences between student groups. Students expressed that AR was beneficial in increasing their motivation to study subcortical structures, and that AR could be helpful and motivating for preparing an anatomy examination. This study suggests that students are motivated to study neuroanatomy by the use of AR, although the components that make up their individual motivation can differ significantly between groups of students.

Published
2022
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10. Accounting for retarded weathering products in comparing methods for quantifying carbon dioxide removal in a short-term enhanced weathering study.

Author

te Pas, Emily E. E. M., Chang, Elliot, Marklein, Alison R., Comans, Rob N. J., and Hagens, Mathilde

Subjects
ACCOUNTING, CARBON dioxide, SILICATE minerals, ORGANIC compounds, WEATHERING
Abstract

Various approaches are currently used to quantify the carbon dioxide removal (CDR) associated with enhanced weathering (EW), which involves amending soils with crushed silicate minerals. We aimed to contribute to the development of a standardized procedure for CDR quantification by complementing the results of a recently published soil column experiment, in which crushed olivine, wollastonite, and albite were added to soils, with total fusion ICP-OES analyses of base cation concentrations. CDR quantified by soil-based mass balance approaches was only comparable to leachate-based total alkalinity measurements after correcting for the weathering products that were retained within the soil profile, which we defined as the retarded fraction. The retarded fraction comprised 92.7–98.3% of the weathered cations, indicating that at least in our short-term study (64 days), the majority of weathering products were retained within the soil. Further investigation of the fate of retarded weathering products showed that small portions precipitated as carbonate minerals (up to 34.0%) or adsorbed to reactive surfaces, such as soil organic matter and clay minerals (up to 32.5%). Hence, a large portion of weathering products may be retained in the soil due to strong adsorption and/or further mineral precipitation reactions (31.6–92.7%), with potentially important implications for the quantification of CDR across time. We conclude that soil-based mass balance approaches are useful in quantifying weathering rates and can infer potential CDR ; however, the actual CDR realized for a given time and depth interval can only be constrained after accounting for the retarded fraction. Graphical abstract created in BioRender.com. [ABSTRACT FROM AUTHOR]

Published
2025
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11. Generalized G-estimation and Model Selection

Author

Wallace, M. P., Moodie, E. E. M., and Stephens, D. A.

Subjects
Statistics - Methodology
Abstract

Dynamic treatment regimes (DTRs) aim to formalize personalized medicine by tailoring treatment decisions to individual patient characteristics. G-estimation for DTR identification targets the parameters of a structural nested mean model known as the blip function from which the optimal DTR is derived. Despite considerable work deriving such estimation methods, there has been little focus on extending G-estimation to the case of non-additive effects, non-continuous outcomes or on model selection. We demonstrate how G-estimation can be more widely applied through the use of iteratively-reweighted least squares procedures, and illustrate this for log-linear models. We then derive a quasi-likelihood function for G-estimation within the DTR framework, and show how it can be used to form an information criterion for blip model selection. These developments are demonstrated through application to a variety of simulation studies as well as data from the Sequenced Treatment Alternatives to Relieve Depression study.

Published
2017

12. Multicriterial Approach for Traditional Shop Houses Façade Condition Assessment

Author

Rahman, M. A. A., Rahman, S. A., Adnan, S. H., Safian, E. E. M., Hashim, N., Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, di Mare, Francesca, Series Editor, Zaini, Muhammad Abbas Ahmad, editor, Jusoh, Mazura, editor, and Othman, Norasikin, editor

Published
2021
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13. Assessment of the enhanced weathering potential of different silicate minerals to improve soil quality and sequester CO2

Author

Emily E. E. M. te Pas, Mathilde Hagens, and Rob N. J. Comans

Subjects
enhanced weathering potential, silicate minerals and rocks, net CO2 sequestration, agricultural soil quality, nickel, soil column experiment, Environmental sciences, GE1-350
Abstract

Enhanced weathering is a negative emission technology that involves the spread of crushed silicate minerals and rocks on land and water. When applied to agricultural soils, the resulting increase in soil pH and release of nutrients may co-benefit plant productivity. Silicate minerals and rocks differ in their enhanced weathering potential, i.e., their potential for both carbon dioxide (CO2) sequestration and soil quality improvements. However, studies comparing silicate minerals and rocks for this dual potential are lacking. Therefore, we compared the enhanced weathering potential of olivine (Mg2SiO4), basalt, wollastonite (CaSiO3), and two minerals that are novel in this context, anorthite (CaAl2Si2O8) and albite (NaAlSi3O8). A down-flow soil column experiment was designed allowing for measurements on soils and leachate, and calculations of organic and inorganic carbon budgets. Our results showed comparatively high CO2 capture by enhanced wollastonite and olivine weathering. Furthermore, CO2 capture per m2 specific surface area indicated potential for enhanced anorthite and albite weathering. Calculated carbon budgets showed that most treatments produced net CO2 emissions from soils, likely related to the short duration of this experiment. All silicates generally improved soil quality, with soil nickel contents remaining below contamination limits. However, nickel concentrations in leachates from olivine-amended soils exceeded the groundwater threshold value, stressing the importance of monitoring nickel leaching. We found a relatively high enhanced weathering potential for wollastonite, while the potential for olivine may be constrained by nickel leaching. The promising results for anorthite and albite indicate the need to further quantify their enhanced weathering potential.

Published
2023
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14. High Temperature Effects on Compactlike Structures

Author

Bazeia, D., Lima, E. E. M., and Losano, L.

Subjects
High Energy Physics - Theory
Abstract

In this work we investigate the transition from kinks to compactons at high temperatures. We deal with a family of models, described by a real scalar field with standard kinematics, controlled by a single parameter, real and positive. The family of models supports kinklike solutions, and the solutions tend to become compact when the parameter increases to larger and larger values. We study the one-loop corrections at finite temperature, to see how the thermal effects add to the effective potential. The results suggest that the symmetry is restored at very high temperatures., Comment: 6 pages, 4 figures; version to apppear in EPJC

Published
2016
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17. Development and Portability of a Text Mining Algorithm for Capturing Disease Progression in Electronic Health Records of Patients With Stage IV Non-Small Cell Lung Cancer

Author

Verschueren, M V, Abedian Kalkhoran, H, Deenen, M, van den Borne, B E E M, Zwaveling, J, Visser, L E, Bloem, L T, Peters, B J M, van de Garde, E M W, Verschueren, M V, Abedian Kalkhoran, H, Deenen, M, van den Borne, B E E M, Zwaveling, J, Visser, L E, Bloem, L T, Peters, B J M, and van de Garde, E M W

Abstract

PURPOSE: The objective was to develop and evaluate the portability of a text mining algorithm for prospectively capturing disease progression in electronic health record (EHR) data of patients with metastatic non-small cell lung cancer (mNSCLC) treated with immunochemotherapy.METHODS: This study used EHR data from patients with mNSCLC receiving immunochemotherapy (between October 1, 2018, and December 31, 2022) in four Dutch hospitals. A text mining algorithm for capturing disease progression was developed in hospitals 1 and 2 and then transferred to hospitals 3 and 4 to evaluate portability. Performance metrics were calculated by comparing its outcomes with manual chart review. In addition, data were simulated to come available over time to assess performance in real-time applications. Median progression-free survival (PFS) was calculated using the Kaplan-Meier method to compare text mining with manual chart review.RESULTS: During development and portability, the text mining algorithm performed well in capturing disease progression, with all performance scores >90%. When real-time performance was simulated, the performance scores in all four hospitals exceeded 90% from week 15 after the start of follow-up. Although the exact progression dates varied in 46 patients of 157 patients with progressive disease, the number of patients labeled with progression too early (n = 24) and too late (n = 22) was well balanced with discrepancies ranging from -116 to 384 days. Nevertheless, the PFS curves constructed with text mining and manual chart review were highly similar for each hospital.CONCLUSION: In this study, an accurate text mining algorithm for capturing disease progression in the EHR data of patients with mNSCLC was developed. The algorithm was portable across different hospitals, and the performance over time was good, making this an interesting approach for prospective follow-up of multicenter cohorts.

Published
2024

20. Numerical Results for the System Noise Temperature of an Aperture Array Tile and Comparison with Measurements

Author

Ivashina, M. V., Woestenburg, E. E. M., Bakker, L., and Witvers, R. H.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The purpose of this report is to document the noise performance of a complex beamforming array antenna system and to characterize the recently developed noise measurement facility called THACO, which was developed at ASTRON. The receiver system includes the array antenna of strongly coupled 144 TSA elements, 144 Low Noise Amplifiers (LNAs) (Tmin =35-40K) and the data recording/storing facilities of the initial test station that allow for off-line digital beamforming. The primary goal of this study is to compare the measured receiver noise temperatures with the simulated values for several practical beamformers, and to predict the associated receiver noise coupling contribution, antenna thermal noise and ground noise pick-up (due to the back radiation)., Comment: ASTRON report

Published
2011

21. Experimental Results of the Sensitivity of a Low Noise Aperture Array Tile for the SKA

Author

Woestenburg, E. E. M., Bakker, L., and Ivashina, M. V.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Aperture arrays have been studied extensively for application in the next generation of large radio telescopes for astronomy, requiring extremely low noise performance. Prototype array systems need to demonstrate the low noise potential of aperture array technology. This paper presents noise measurements for an Aperture Array tile of 144 dual-polarized tapered slot antenna (TSA) elements, originally built and characterized for use as a Phased Array Feed for application in an L-band radio astronomical receiving system. The system noise budget is given and the dependency of the measured noise temperatures on the beam steering is discussed. A comparison is made of the measurement results with simulations of the noise behavior using a system noise model. This model includes the effect of receiver noise coupling, resulting from a changing active reflection coefficient and array noise contribution as a function of beam steering. Measurement results clearly demonstrate the validity of the model and thus the concept of active reflection coefficient for the calculation of effective system noise temperatures. The presented array noise temperatures, with a best measured value of 45 K, are state-of-the-art for room temperature aperture arrays in the 1 GHz range and illustrate their low noise potential., Comment: 6 pages, 6 figures, accepted for publication in the IEEE Transactions on Antennas and Propagation

Published
2011
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22. THACO, a Test Facility for Characterizing the Noise Performance of Active Antenna Arrays

Author

Woestenburg, E. E. M., Bakker, L., Ruiter, M., Ivashina, M. V., and Witvers, R. H.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This paper discusses an outdoor test facility for the noise characterization of active antenna arrays, using measurement results of array noise temperatures in the order of 50 K for a number of small aperture arrays. The measurement results are obtained by a Y-factor method with hot and a cold noise sources, with an absorber at room temperature as the hot load and the cold sky as the cold load. The effect of shielding the arrays by the test facility, with respect to noise and RFI from the environment, will also be discussed., Comment: 4 pages, 6 figures. Official Publication: Microwave Journal; Proc. of European Microwave Week (EuMW2011), October 9th-14th, 2011

Published
2011

23. Magnetism in graphite oxide: The role of epoxy groups

Author

Lee, D. W., Cole, J. M., Seo, J. W., Saxena, S. S., Barnes, C. H. W., Chia, E. E. M., and Panagopoulos, C.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the magnetism in graphite by controlled oxidation. Our approach renders graphite an insulator while maintaining its structure. Fourier transform infrared spectroscopy and X-ray absorption near edge structure spectra reveal that graphite oxide has epoxy groups on its surface and it is not thermally stable. Magnetic susceptibility data exhibit negative Curie temperature, field irreversibility, and slow relaxation. The magnetic properties diminish after the epoxy groups are destroyed. The overall results indicate the unexpected magnetism is associated with the presence of epoxy groups., Comment: This paper has been withdrawn by the author due to an error in dealing with data

Published
2010

25. Efficacy of Ibandronate Loading Dose on Rapid Pain Relief in Patients With Non-Small Cell Lung Cancer and Cancer Induced Bone Pain: The NVALT-9 Trial

Author

Anita J. W. M. Brouns, Lizza E. L. Hendriks, Vincent van der Noort, Ben E. E. M van de Borne, Franz M. N. H. Schramel, Harry J. M. Groen, Bonne Biesma, Hans J. M. Smit, and Anne-Marie C. Dingemans

Subjects
carcinoma, non-small-cell lung, pain management, cancer induced bone pain, clinical trials, phase II as topic, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Approximately 80% of non-small cell lung cancer (NSCLC) patients with bone metastases have cancer induced bone pain (CIBP).Methods: The NVALT-9 was an open-label, single arm, phase II, multicenter study. Main inclusion criterion: bone metastasized NSCLC patients with uncontrolled CIBP [brief pain inventory [BPI] ≥ 5 over last 7 days]. Patients were treated with six milligram ibandronate intravenously (day 1–3) once a day. Main exclusion criteria: active secondary malignancy, systemic anti-tumor treatment and radiotherapy ≤4 weeks before study start, previous bisphosphonate treatment. Statistics: Simon's Optimal two-stage design with a 90% power to declare the treatment active if the pain response rate is ≥ 80% and 95% confidence to declare the treatment inactive if the pain response rate is ≤ 60%. If pain response is observed in ≤ 12 of the first 19 patients further enrollment will be stopped. Primary endpoint: bone pain response, defined as 25% decrease in worst pain score (PSc) over a 3-day period (day 5–7) compared to baseline PSc with maximum of 25% increase in mean analgesic consumption during the same period. Secondary endpoints: BPI score, quality of life, toxicity and World Health Organization Performance Score.Results: Of the 19 enrolled patients in the first stage, 18 were evaluable for response. All completed ibandronate treatment according to protocol. In 4 (22.2%), a bone pain response was observed. According to the stopping rule, further enrollment was halted.Discussion: Ibandronate loading doses lead to insufficient pain relief in NSCLC patients with CIBP.

Published
2020
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33. I‌N‌V‌E‌S‌T‌I‌G‌A‌T‌I‌N‌G T‌H‌E C‌R‌I‌T‌I‌C‌A‌L S‌T‌A‌T‌E B‌E‌H‌A‌V‌I‌O‌R O‌F C‌L‌A‌Y‌E‌Y S‌A‌N‌D U‌N‌D‌E‌R S‌T‌A‌T‌I‌C A‌N‌D C‌Y‌C‌L‌I‌C L‌O‌A‌D‌I‌N‌G.

Author

O. N‌a‌e‌e‌m‌i‌f‌a‌r and S.S. Y‌a‌s‌r‌o‌b‌i

Subjects
c‌y‌c‌l‌i‌c, s‌t‌a‌t‌i‌c, s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e, t‌r‌i‌a‌x‌i‌a‌l, t‌h‌r‌e‌s‌h‌o‌l‌d v‌a‌l‌u‌e, Building construction, TH1-9745
Abstract

O‌b‌s‌e‌r‌v‌a‌t‌i‌o‌n o‌f s‌u‌c‌h p‌h‌e‌n‌o‌m‌e‌n‌a a‌s l‌i‌q‌u‌e‌f‌a‌c‌t‌i‌o‌n a‌n‌d f‌l‌o‌w b‌e‌h‌a‌v‌i‌o‌r g‌e‌n‌e‌r‌a‌l‌l‌y o‌c‌c‌u‌r‌r‌i‌n‌g i‌n l‌o‌o‌s‌e a‌n‌d s‌a‌t‌u‌r‌a‌t‌e‌d s‌a‌n‌d‌s h‌a‌v‌e ‌t‌i‌m‌u‌l‌a‌t‌e‌d e‌x‌t‌e‌n‌s‌i‌v‌e i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌i‌o‌n i‌n‌t‌o s‌a‌n‌d‌s a‌n‌d t‌h‌e p‌a‌r‌a‌m‌e‌t‌e‌r‌s i‌n‌v‌o‌l‌v‌e‌d i‌n t‌h‌e‌i‌r c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e b‌e‌h‌a‌v‌i‌o‌r.M‌o‌s‌t s‌t‌u‌d‌i‌e‌s c‌o‌n‌d‌u‌c‌t‌e‌d s‌o f‌a‌r h‌a‌v‌e m‌a‌i‌n‌l‌y f‌o‌c‌u‌s‌e‌d o‌n c‌l‌e‌a‌n s‌a‌n‌d o‌r i‌t‌s m‌i‌x‌t‌u‌r‌e‌s c‌o‌n‌t‌a‌i‌n‌i‌n‌g n‌o‌n-p‌l‌a‌s‌t‌i‌c f‌i‌n‌e‌s, w‌i‌t‌h n‌o‌t m‌u‌c‌h a‌t‌t‌e‌n‌t‌i‌o‌n p‌a‌i‌d t‌o t‌h‌e s‌o‌i‌l m‌e‌c‌h‌a‌n‌i‌c‌s o‌f t‌h‌e c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e o‌f c‌l‌a‌y‌e‌y s‌a‌n‌d‌s. T‌h‌e r‌e‌a‌s‌o‌n f‌o‌r t‌h‌i‌s n‌e‌g‌l‌e‌c‌t m‌a‌y b‌e t‌h‌e m‌i‌s‌c‌o‌n‌c‌e‌p‌t‌i‌o‌n t‌h‌a‌t p‌l‌a‌s‌t‌i‌c p‌r‌o‌p‌e‌r‌t‌i‌e‌s i‌n c‌l‌a‌y p‌r‌o‌h‌i‌b‌i‌t f‌l‌o‌w b‌e‌h‌a‌v‌i‌o‌r a‌n‌d l‌i‌q‌u‌e‌f‌a‌c‌t‌i‌o‌n. H‌o‌w‌e‌v‌e‌r, t‌h‌e s‌t‌u‌d‌i‌e‌s o‌f t‌h‌e N‌o‌r‌t‌h‌r‌i‌d‌g‌e 1994, K‌o‌k‌a‌e‌l‌i 1999, C‌h‌i C‌h‌i 1999, a‌n‌d N‌i‌i‌g‌a‌t‌a 2004 e‌a‌r‌t‌h‌q‌u‌a‌k‌e‌s h‌a‌v‌e i‌n‌d‌i‌c‌a‌t‌e‌d t‌h‌a‌t n‌o‌t‌a‌b‌l‌e s‌e‌t‌t‌l‌e‌m‌e‌n‌t‌s o‌c‌c‌u‌r i‌n s‌o‌i‌l c‌o‌n‌t‌a‌i‌n‌i‌n‌g c‌o‌n‌s‌i‌d‌e‌r‌a‌b‌l‌e a‌m‌o‌u‌n‌t‌s o‌f c‌l‌a‌y, r‌e‌s‌u‌l‌t‌i‌n‌g i‌n g‌r‌e‌a‌t d‌e‌s‌t‌r‌u‌c‌t‌i‌o‌n. R‌e‌s‌e‌a‌r‌c‌h‌e‌r‌s h‌a‌v‌e e‌m‌p‌h‌a‌s‌i‌z‌e‌d t‌h‌a‌t m‌o‌r‌e d‌e‌t‌a‌i‌l‌e‌d i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌i‌o‌n i‌s n‌e‌e‌d‌e‌d t‌o d‌e‌t‌e‌r‌m‌i‌n‌e t‌h‌e c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e b‌e‌h‌a‌v‌i‌o‌r o‌f c‌l‌a‌y‌e‌y s‌a‌n‌d‌s. T‌h‌e c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e b‌e‌h‌a‌v‌i‌o‌r o‌f c‌l‌a‌y‌e‌y s‌a‌n‌d‌s h‌a‌s b‌e‌e‌n i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌e‌d u‌s‌i‌n‌g c‌y‌c‌l‌i‌c a‌n‌d s‌t‌a‌t‌i‌c t‌r‌i‌a‌x‌i‌a‌l t‌e‌s‌t‌s. B‌a‌s‌e‌d o‌n t‌h‌e r‌e‌s‌u‌l‌t‌s, i‌n l‌o‌w f‌i‌n‌e c‌o‌n‌t‌e‌n‌t, m‌o‌r‌e d‌e‌n‌s‌i‌t‌y w‌i‌l‌l r‌e‌s‌u‌l‌t i‌n a s‌i‌g‌n‌i‌f‌i‌c‌a‌n‌t i‌n‌c‌r‌e‌a‌s‌e i‌n s‌t‌e‌a‌d‌y s‌t‌a‌t‌e s‌t‌r‌e‌n‌g‌t‌h, w‌h‌i‌l‌e, a‌t h‌i‌g‌h f‌i‌n‌e c‌o‌n‌t‌e‌n‌t, t‌h‌e e‌f‌f‌e‌c‌t o‌f d‌e‌n‌s‌i‌t‌y o‌n t‌h‌e s‌t‌e‌a‌d‌y s‌t‌a‌t‌e s‌t‌r‌e‌n‌g‌t‌h w‌o‌u‌l‌d b‌e i‌n‌s‌i‌g‌n‌i‌f‌i‌c‌a‌n‌t. A‌l‌s‌o, i‌n‌c‌r‌e‌a‌s‌i‌n‌g f‌i‌n‌e c‌o‌n‌t‌e‌n‌t r‌e‌s‌u‌l‌t‌s i‌n m‌o‌r‌e i‌n‌s‌t‌a‌b‌i‌l‌i‌t‌y, b‌u‌t t‌h‌e t‌r‌e‌n‌d r‌e‌v‌e‌r‌s‌e‌s a‌f‌t‌e‌r a t‌h‌r‌e‌s‌h‌o‌l‌d v‌a‌l‌u‌e. T‌h‌i‌s t‌h‌r‌e‌s‌h‌o‌l‌d v‌a‌l‌u‌e i‌s i‌n‌d‌e‌p‌e‌n‌d‌e‌n‌t o‌f c‌y‌c‌l‌i‌c o‌r s‌t‌a‌t‌i‌c l‌o‌a‌d‌i‌n‌g.C‌o‌m‌p‌a‌r‌i‌n‌g t‌h‌e r‌e‌s‌u‌l‌t‌s o‌f d‌i‌f‌f‌e‌r‌e‌n‌t p‌l‌a‌s‌t‌i‌c‌i‌t‌y f‌i‌n‌e‌s u‌n‌d‌e‌r s‌i‌m‌i‌l‌a‌r c‌o‌n‌d‌i‌t‌i‌o‌n‌s s‌h‌o‌w‌s t‌h‌a‌t i‌n‌c‌r‌e‌a‌s‌i‌n‌g p‌l‌a‌s‌t‌i‌c‌i‌t‌y l‌e‌a‌d‌s t‌o m‌o‌r‌e i‌n‌s‌t‌a‌b‌i‌l‌i‌t‌y u‌n‌d‌e‌r t‌h‌e t‌h‌r‌e‌s‌h‌o‌l‌d v‌a‌l‌u‌e, w‌h‌i‌l‌e t‌h‌e e‌f‌f‌e‌c‌t o‌f p‌l‌a‌s‌t‌i‌c‌i‌t‌y w‌i‌l‌l b‌e m‌o‌r‌e s‌i‌g‌n‌i‌f‌i‌c‌a‌n‌t w‌i‌t‌h a‌n i‌n‌c‌r‌e‌a‌s‌e i‌n f‌i‌n‌e c‌o‌n‌t‌e‌n‌tF‌i‌r‌o‌o‌z-k‌o‌o‌h c‌r‌a‌s‌h‌e‌d s‌i‌l‌i‌c‌a s‌a‌n‌d (s‌a‌n‌d 161) w‌a‌s u‌s‌e‌d i‌n t‌h‌e e‌x‌p‌e‌r‌i‌m‌e‌n‌t‌s d‌u‌e t‌o i‌t‌s d‌e‌s‌i‌r‌a‌b‌l‌e p‌r‌o‌p‌e‌r‌t‌i‌e‌s. S‌p‌e‌c‌i‌m‌e‌n‌s w‌e‌r‌e p‌r‌e‌p‌a‌r‌e‌d u‌s‌i‌n‌g t‌h‌e w‌e‌t t‌a‌m‌p‌i‌n‌g m‌e‌t‌h‌o‌d. H‌a‌v‌i‌n‌g o‌b‌t‌a‌i‌n‌e‌d t‌h‌e a‌p‌p‌r‌o‌p‌r‌i‌a‌t‌e b‌l‌e‌n‌d, i‌t w‌a‌s p‌o‌u‌r‌e‌d i‌n‌t‌o a s‌p‌e‌c‌i‌a‌l m‌o‌u‌l‌d a‌n‌d c‌o‌m‌p‌a‌c‌t‌e‌d i‌n 6 l‌a‌y‌e‌r‌s t‌o p‌r‌e‌p‌a‌r‌e s‌p‌e‌c‌i‌m‌e‌n‌s 50 m‌m i‌n d‌i‌a‌m‌e‌t‌e‌r a‌n‌d 100 m‌m i‌n h‌e‌i‌g‌h‌t.

Published
2016

34. U‌N‌I‌Q‌U‌E F‌R‌A‌M‌E W‌O‌R‌K F‌O‌R I‌N‌T‌E‌R‌P‌R‌E‌T‌A‌T‌I‌O‌N O‌F T‌H‌E C‌R‌I‌T‌I‌C‌A‌L S‌T‌A‌T‌E B‌E‌H‌A‌V‌I‌O‌R O‌F C‌L‌A‌Y‌E‌Y S‌A‌N‌D‌S

Author

O. N‌a‌e‌e‌m‌i‌f‌a‌r and S.s y‌a‌s‌r‌o‌b‌i‌s

Subjects
s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e, t‌r‌i‌a‌x‌i‌a‌l, e‌q‌u‌i‌v‌a‌l‌e‌n‌t v‌o‌i‌d r‌a‌t‌i‌o, b p‌a‌r‌a‌m‌e‌t‌e‌r, Building construction, TH1-9745
Abstract

T‌h‌e s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e o‌r c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e l‌i‌n‌e i‌s o‌n‌e o‌f t‌h‌e m‌a‌i‌n f‌a‌c‌t‌o‌r‌s u‌s‌e‌d i‌n c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e t‌o‌p‌i‌c‌s. I‌t i‌s u‌s‌e‌d f‌o‌r i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌i‌n‌g t‌h‌e v‌a‌r‌i‌a‌t‌i‌o‌n o‌f l‌i‌q‌u‌e‌f‌a‌c‌t‌i‌o‌n p‌o‌t‌e‌n‌t‌i‌a‌l, c‌a‌l‌c‌u‌l‌a‌t‌i‌n‌g s‌t‌a‌t‌e p‌a‌r‌a‌m‌e‌t‌e‌r‌s a‌n‌d a‌l‌s‌o d‌e‌t‌e‌r‌m‌i‌n‌i‌n‌g t‌h‌e p‌a‌r‌a‌m‌e‌t‌e‌r‌s a‌f‌f‌e‌c‌t‌i‌n‌g c‌o‌l‌l‌a‌p‌s‌e o‌r s‌t‌a‌t‌e b‌o‌u‌n‌d‌a‌r‌y s‌u‌r‌f‌a‌c‌e s‌h‌a‌p‌e‌s. S‌a‌n‌d s‌k‌e‌l‌e‌t‌o‌n v‌o‌i‌d r‌a‌t‌i‌o, e‌q‌u‌i‌v‌a‌l‌e‌n‌t v‌o‌i‌d r‌a‌t‌i‌o a‌n‌d t‌h‌e i‌n‌t‌e‌r‌a‌c‌t‌i‌o‌n o‌f s‌a‌n‌d a‌n‌d f‌i‌n‌e‌s a‌r‌e m‌a‌i‌n s‌u‌b‌j‌e‌c‌t‌s b‌e‌h‌i‌n‌d r‌e‌s‌e‌a‌r‌c‌h i‌n‌t‌o s‌a‌n‌d c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e b‌e‌h‌a‌v‌i‌o‌r.M‌o‌s‌t s‌t‌u‌d‌i‌e‌s c‌o‌n‌d‌u‌c‌t‌e‌d s‌o f‌a‌r h‌a‌v‌e m‌a‌i‌n‌l‌y f‌o‌c‌u‌s‌e‌d o‌n c‌l‌e‌a‌n s‌a‌n‌d o‌r i‌t‌s m‌i‌x‌t‌u‌r‌e‌s c‌o‌n‌t‌a‌i‌n‌i‌n‌g n‌o‌n-p‌l‌a‌s‌t‌i‌c f‌i‌n‌e‌s w‌i‌t‌h n‌o‌t m‌u‌c‌h a‌t‌t‌e‌n‌t‌i‌o‌n p‌a‌i‌d t‌o t‌h‌e s‌o‌i‌l m‌e‌c‌h‌a‌n‌i‌c‌s o‌f t‌h‌e c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e o‌f c‌l‌a‌y‌e‌y s‌a‌n‌d‌s. T‌h‌e r‌e‌a‌s‌o‌n f‌o‌r t‌h‌i‌s n‌e‌g‌l‌e‌c‌t m‌i‌g‌h‌t b‌e t‌h‌e m‌i‌s‌c‌o‌n‌c‌e‌p‌t‌i‌o‌n t‌h‌a‌t p‌l‌a‌s‌t‌i‌c p‌r‌o‌p‌e‌r‌t‌i‌e‌s i‌n c‌l‌a‌y p‌r‌o‌h‌i‌b‌i‌t f‌l‌o‌w b‌e‌h‌a‌v‌i‌o‌u‌r a‌n‌d l‌i‌q‌u‌e‌f‌a‌c‌t‌i‌o‌n. H‌o‌w‌e‌v‌e‌r, t‌h‌e s‌t‌u‌d‌i‌e‌s o‌f N‌o‌r‌t‌h‌r‌i‌d‌g‌e 1994, K‌o‌k‌a‌e‌l‌i 1999, C‌h‌i C‌h‌i 1999, a‌n‌d N‌i‌i‌g‌a‌t‌a 2004 e‌a‌r‌t‌h‌q‌u‌a‌k‌e‌s h‌a‌v‌e i‌n‌d‌i‌c‌a‌t‌e‌d t‌h‌a‌t n‌o‌t‌a‌b‌l‌e s‌e‌t‌t‌l‌e‌m‌e‌n‌t‌s o‌c‌c‌u‌r i‌n s‌o‌i‌l‌s c‌o‌n‌t‌a‌i‌n‌i‌n‌g c‌o‌n‌s‌i‌d‌e‌r‌a‌b‌l‌e a‌m‌o‌u‌n‌t‌s o‌f c‌l‌a‌y, r‌e‌s‌u‌l‌t‌i‌n‌g i‌n g‌r‌e‌a‌t d‌e‌s‌t‌r‌u‌c‌t‌i‌o‌n. R‌e‌s‌e‌a‌r‌c‌h‌e‌r‌s h‌a‌v‌e e‌m‌p‌h‌a‌s‌i‌z‌e‌d t‌h‌a‌t m‌o‌r‌e d‌e‌t‌a‌i‌l‌e‌d i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌i‌o‌n i‌s n‌e‌e‌d‌e‌d t‌o d‌e‌t‌e‌r‌m‌i‌n‌e t‌h‌e c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e b‌e‌h‌a‌v‌i‌o‌u‌r o‌f c‌l‌a‌y‌e‌y s‌a‌n‌d‌s.F‌o‌l‌l‌o‌w‌i‌n‌g, t‌h‌e p‌o‌s‌s‌i‌b‌i‌l‌i‌t‌y o‌f p‌r‌e‌s‌e‌n‌t‌i‌n‌g a u‌n‌i‌q‌u‌e f‌r‌a‌m‌e w‌o‌r‌k f‌o‌r i‌n‌t‌e‌r‌p‌r‌e‌t‌a‌t‌i‌o‌n o‌f c‌r‌i‌t‌i‌c‌a‌l s‌t‌a‌t‌e c‌l‌a‌y‌e‌y s‌a‌n‌d b‌e‌h‌a‌v‌i‌o‌r i‌s i‌n‌v‌e‌s‌t‌i‌g‌a‌t‌e‌d, b‌a‌s‌e‌d o‌n s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e‌s a‌n‌d e‌q‌u‌i‌v‌a‌l‌e‌n‌t v‌o‌i‌d r‌a‌t‌i‌o.T‌r‌i‌a‌x‌i‌a‌l e‌x‌p‌e‌r‌i‌m‌e‌n‌t‌s a‌r‌e p‌e‌r‌f‌o‌r‌m‌e‌d o‌n t‌h‌e s‌a‌n‌d a‌n‌d i‌t‌s c‌o‌m‌b‌i‌n‌a‌t‌i‌o‌n w‌i‌t‌h 0 t‌o 25 p‌e‌r‌c‌e‌n‌t m‌e‌d‌i‌u‌m p‌l‌a‌s‌t‌i‌c‌i‌t‌y c‌l‌a‌y, r‌e‌s‌u‌l‌t‌i‌n‌g i‌n a n‌e‌w r‌e‌l‌a‌t‌i‌o‌n u‌s‌e‌d t‌o c‌a‌l‌c‌u‌l‌a‌t‌e t‌h‌e b p‌a‌r‌a‌m‌e‌t‌e‌r‌s. T‌h‌e‌s‌e a‌r‌e p‌r‌e‌s‌e‌n‌t‌e‌d b‌a‌s‌e‌d o‌n t‌h‌e f‌i‌n‌e a‌n‌d s‌a‌n‌d i‌n‌t‌e‌r‌a‌c‌t‌i‌o‌n c‌o‌n‌c‌e‌p‌t a‌n‌d a‌l‌s‌o s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e‌s.T‌h‌e r‌e‌s‌u‌l‌t‌s h‌a‌v‌e p‌r‌o‌v‌e‌d t‌h‌a‌t b‌y u‌s‌i‌n‌g t‌h‌e p‌r‌o‌p‌o‌s‌e‌d r‌e‌l‌a‌t‌i‌o‌n, i‌t w‌i‌l‌l b‌e p‌o‌s‌s‌i‌b‌l‌e t‌o c‌o‌n‌v‌e‌r‌t t‌h‌e d‌i‌f‌f‌e‌r‌e‌n‌t s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e o‌f s‌a‌n‌d, a‌n‌d i‌t‌s c‌o‌m‌b‌i‌n‌a‌t‌i‌o‌n w‌i‌t‌h c‌l‌a‌y, i‌n‌t‌o o‌n‌e u‌n‌i‌q‌u‌e l‌i‌n‌e. A‌l‌s‌o, i‌t w‌i‌l‌l b‌e p‌o‌s‌s‌i‌b‌l‌e t‌o a‌t‌t‌a‌i‌n t‌h‌e s‌t‌e‌a‌d‌y s‌t‌a‌t‌e l‌i‌n‌e‌s o‌f s‌a‌n‌d, a‌n‌d a‌l‌l i‌t‌s c‌o‌m‌b‌i‌n‌a‌t‌i‌o‌n‌s w‌i‌t‌h c‌l‌a‌y, b‌a‌s‌e‌d o‌n o‌n‌l‌y s‌o‌m‌e t‌e‌s‌t‌s p‌e‌r‌f‌o‌r‌m‌e‌d o‌n c‌l‌e‌a‌n s‌a‌n‌d s‌p‌e‌c‌i‌m‌e‌n‌s. I‌n o‌r‌d‌e‌r t‌o g‌e‌n‌e‌r‌a‌l‌i‌z‌e t‌h‌e p‌r‌o‌p‌o‌s‌e‌d r‌e‌l‌a‌t‌i‌o‌n, i‌t i‌s v‌e‌r‌i‌f‌i‌e‌d u‌s‌i‌n‌g o‌t‌h‌e‌r a‌v‌a‌i‌l‌a‌b‌l‌e r‌e‌s‌u‌l‌t‌s.

Published
2016

35. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials

Author

Chang, Joe Y, Senan, Suresh, Paul, Marinus A, Mehran, Reza J, Louie, Alexander V, Balter, Peter, Groen, Harry J M, McRae, Stephen E, Widder, Joachim, Feng, Lei, van den Borne, Ben E E M, Munsell, Mark F, Hurkmans, Coen, Berry, Donald A, van Werkhoven, Erik, Kresl, John J, Dingemans, Anne-Marie, Dawood, Omar, Haasbeek, Cornelis J A, Carpenter, Larry S, De Jaeger, Katrien, Komaki, Ritsuko, Slotman, Ben J, Smit, Egbert F, and Roth, Jack A

Published
2015
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36. Dual-phase-lag model on microelongated thermoelastic rotating medium

Author

Mohamed I. A. Othman, Sarhan Y. Atwa, E. E. M. Eraki, and Mohamed F. Ismail

Abstract

The dual-phase-lag (DPL) model is applied to study the influence of rotation on a two-dimensional micro-elongated thermoelastic medium problem. Mechanical force along with the layer of the elastic half-space interface and micro-elongated thermoelastic half-space is applied. The analytic expressions for displacement component, temperature distribution, micro-elongational scalar and stress components have been derived and represented graphically. The rotation has been studied in the presence DPL model and Lord-Shulman theory.

Published
2022
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37. Association Between Plasma Neutrophil Gelatinase‐Associated Lipocalin and Cardiac Disease Hospitalizations and Deaths in Older Women

Author

James J. H. Chong, Richard L. Prince, Peter L. Thompson, Sujitha Thavapalachandran, Esther Ooi, Amanda Devine, E. E. M. Lim, Elizabeth Byrnes, Germaine Wong, Wai H. Lim, and Joshua R. Lewis

Subjects
coronary heart disease, elderly, lipocalin 2, myocyte necrosis, neutrophil gelatinase‐associated lipocalin, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Neutrophil gelatinase‐associated lipocalin (NGAL) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL, cardiovascular disease biomarkers, and long‐term cardiac events. Methods and Results The study population consisted of 1131 ambulant older white women (mean age 75 years) without clinical coronary heart disease (CHD) and measures of plasma NGAL in the Perth Longitudinal Study of Ageing Women with 14.5‐year CHD and heart failure hospitalizations or death (events) captured using linked records. Over 14.5 years, 256 women had CHD events, while 118 had heart failure events. Per SD increase in log‐transformed NGAL there was a 35% to 37% increase in relative hazards for CHD and heart failure events in unadjusted analyses, which remained significant after adjustment for conventional risk factors for CHD events (hazard ratio 1.29, 95% CI 1.13–1.48, P0.05). Women in the highest 2 quartiles of NGAL had higher relative hazards for CHD events compared with women in the lowest quartile hazard ratio 1.61, 95% CI 1.08–2.39, P=0.019 and hazard ratio 1.97, 95% CI 1.33–3.93, P=0.001, respectively. These associations were independent of high‐sensitivity cardiac troponin I, homocysteine, and estimated renal function. NGAL correctly reclassified 1 in 4 women who sustained a CHD event up in risk and 1 in 10 women without CHD events down in risk. Conclusions NGAL was associated with increased risk of long‐term CHD events, independent of conventional risk factors and biomarkers. These findings provide mechanistic insight into the role of NGAL with cardiac events.

Published
2019
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42. Genome-wide autozygosity is associated with lower general cognitive ability

Author

Howrigan, D P, Simonson, M A, Davies, G, Harris, S E, Tenesa, A, Starr, J M, Liewald, D C, Deary, I J, McRae, A, Wright, M J, Montgomery, G W, Hansell, N, Martin, N G, Payton, A, Horan, M, Ollier, W E, Abdellaoui, A, Boomsma, D I, DeRosse, P, Knowles, E E M, Glahn, D C, Djurovic, S, Melle, I, Andreassen, O A, Christoforou, A, Steen, V M, Hellard, S L, Sundet, K, Reinvang, I, Espeseth, T, Lundervold, A J, Giegling, I, Konte, B, Hartmann, A M, Rujescu, D, Roussos, P, Giakoumaki, S, Burdick, K E, Bitsios, P, Donohoe, G, Corley, R P, Visscher, P M, Pendleton, N, Malhotra, A K, Neale, B M, Lencz, T, and Keller, M C

Published
2016
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44. First release of Apertif imaging survey data

Author

Adams, E. A. K., primary, Adebahr, B., additional, de Blok, W. J. G., additional, Dénes, H., additional, Hess, K. M., additional, van der Hulst, J. M., additional, Kutkin, A., additional, Lucero, D. M., additional, Morganti, R., additional, Moss, V. A., additional, Oosterloo, T. A., additional, Orrú, E., additional, Schulz, R., additional, van Amesfoort, A. S., additional, Berger, A., additional, Boersma, O. M., additional, Bouwhuis, M., additional, van den Brink, R., additional, van Cappellen, W. A., additional, Connor, L., additional, Coolen, A. H. W. M., additional, Damstra, S., additional, van Diepen, G. N. J., additional, Dijkema, T. J., additional, Ebbendorf, N., additional, Grange, Y. G., additional, de Goei, R., additional, Gunst, A. W., additional, Holties, H. A., additional, Hut, B., additional, Ivashina, M. V., additional, Józsa, G. I. G., additional, van Leeuwen, J., additional, Loose, G. M., additional, Maan, Y., additional, Mancini, M., additional, Mika, Á., additional, Mulder, H., additional, Norden, M. J., additional, Offringa, A. R., additional, Oostrum, L. C., additional, Pastor-Marazuela, I., additional, Pisano, D. J., additional, Ponomareva, A. A., additional, Romein, J. W., additional, Ruiter, M., additional, Schoenmakers, A. P., additional, van der Schuur, D., additional, Sluman, J. J., additional, Smits, R., additional, Stuurwold, K. J. C., additional, Verstappen, J., additional, Vilchez, N. P. E., additional, Vohl, D., additional, Wierenga, K. J., additional, Wijnholds, S. J., additional, Woestenburg, E. E. M., additional, Zanting, A. W., additional, and Ziemke, J., additional

Published
2022
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45. First release of Apertif imaging survey data

Author

E. A. K. Adams, B. Adebahr, W. J. G. de Blok, H. Dénes, K. M. Hess, J. M. van der Hulst, A. Kutkin, D. M. Lucero, R. Morganti, V. A. Moss, T. A. Oosterloo, E. Orrú, R. Schulz, A. S. van Amesfoort, A. Berger, O. M. Boersma, M. Bouwhuis, R. van den Brink, W. A. van Cappellen, L. Connor, A. H. W. M. Coolen, S. Damstra, G. N. J. van Diepen, T. J. Dijkema, N. Ebbendorf, Y. G. Grange, R. de Goei, A. W. Gunst, H. A. Holties, B. Hut, M. V. Ivashina, G. I. G. Józsa, J. van Leeuwen, G. M. Loose, Y. Maan, M. Mancini, Á. Mika, H. Mulder, M. J. Norden, A. R. Offringa, L. C. Oostrum, I. Pastor-Marazuela, D. J. Pisano, A. A. Ponomareva, J. W. Romein, M. Ruiter, A. P. Schoenmakers, D. van der Schuur, J. J. Sluman, R. Smits, K. J. C. Stuurwold, J. Verstappen, N. P. E. Vilchez, D. Vohl, K. J. Wierenga, S. J. Wijnholds, E. E. M. Woestenburg, A. W. Zanting, J. Ziemke, Astronomy, Kapteyn Astronomical Institute, Ministerio de Ciencia e Innovación (España), European Commission, European Research Council, and German Research Foundation

Subjects
Galaxies: ISM, Radio lines: galaxies, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Polarization, FOS: Physical sciences, Astronomy and Astrophysics, Surveys, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics - Astrophysics of Galaxies, Radio continuum: galaxies
Abstract

Full list of authors: Adams, E. A. K.; Adebahr, B.; de Blok, W. J. G.; Denes, H.; Hess, K. M.; van der Hulst, J. M.; Kutkin, A.; Lucero, D. M.; Morganti, R.; Moss, V. A.; Oosterloo, T. A.; Orru, E.; Schulz, R.; van Amesfoort, A. S.; Berger, A.; Boersma, O. M.; Bouwhuis, M.; van den Brink, R.; van Cappellen, W. A.; Connor, L.; Coolen, A. H. W. M.; Damstra, S.; van Diepen, G. N. J.; Dijkema, T. J.; Ebbendorf, N.; Grange, Y. G.; de Goei, R.; Gunst, A. W.; Holties, H. A.; Hut, B.; Ivashina, M., V; Jozsa, G. I. G.; van Leeuwen, J.; Loose, G. M.; Maan, Y.; Mancini, M.; Mika, A.; Mulder, H.; Norden, M. J.; Offringa, A. R.; Oostrum, L. C.; Pastor-Marazuela, I; Pisano, D. J.; Ponomareva, A. A.; Romein, J. W.; Ruiter, M.; Schoenmakers, A. P.; van der Schuur, D.; Sluman, J. J.; Smits, R.; Stuurwold, K. J. C.; Verstappen, J.; Vilchez, N. P. E.; Vohl, D.; Wierenga, K. J.; Wijnholds, S. J.; Woestenburg, E. E. M.; Zanting, A. W.; Ziemke, J.--Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. Apertif is a phased-array feed system for the Westerbork Synthesis Radio Telescope, providing forty instantaneous beams over 300 MHz of bandwidth. A dedicated survey program utilizing this upgrade started on 1 July 2019, with the last observations taken on 28 February 2022. The imaging survey component provides radio continuum, polarization, and spectral line data. Aims. Public release of data is critical for maximizing the legacy of a survey. Toward that end, we describe the release of data products from the first year of survey operations, through 30 June 2020. In particular, we focus on defining quality control metrics for the processed data products. Methods. The Apertif imaging pipeline, Apercal, automatically produces non-primary beam corrected continuum images, polarization images and cubes, and uncleaned spectral line and dirty beam cubes for each beam of an Apertif imaging observation. For this release, processed data products are considered on a beam-by-beam basis within an observation. We validate the continuum images by using metrics that identify deviations from Gaussian noise in the residual images. If the continuum image passes validation, we release all processed data products for a given beam. We apply further validation to the polarization and line data products and provide flags indicating the quality of those data products. Results. We release all raw observational data from the first year of survey observations, for a total of 221 observations of 160 independent target fields, covering approximately one thousand square degrees of sky. Images and cubes are released on a per beam basis, and 3374 beams (of 7640 considered) are released. The median noise in the continuum images is 41.4 uJy beam−1, with a slightly lower median noise of 36.9 uJy beam−1 in the Stokes V polarization image. The median angular resolution is 11.6″/sin δ. The median noise for all line cubes, with a spectral resolution of 36.6 kHz, is 1.6 mJy beam−1, corresponding to a 3-σ H I column density sensitivity of 1.8 × 1020 atoms cm−2 over 20 km s−1 (for a median angular resolution of 24″ × 15″). Line cubes at lower frequency have slightly higher noise values, consistent with the global RFI environment and overall Apertif system performance. We also provide primary beam images for each individual Apertif compound beam. The data are made accessible using a Virtual Observatory interface and can be queried using a variety of standard tools. © E. A. K. Adams et al. 2022., This work makes use of data from the Apertif system installed at the Westerbork Synthesis Radio Telescope owned by ASTRON. ASTRON, the Netherlands Institute for Radio Astronomy, is an institute of the Dutch Research Council (“De Nederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO). Apertif was partly financed by the NWO Groot projects Apertif (175.010.2005.015) and Apropos (175.010.2009.012). This work was partly supported by funding from the European Research Council under the European Union’s Seventh Frame-work Programme (FP/2007-2013), through ERC Grant Agreement No. 291531 (‘HIStoryNU’, PI: JMvdH) and ERC Advanced Grant RADIOLIFE-320745 (PI: RM), in addition to funding from NWO via grant TOP1EW.14.105 (PI: TAO). E.A.K.A. is supported by the WISE research programme, which is financed by NWO. B.A. acknowledges funding from the German Science Foundation DFG, within the Collaborative Research Center SFB1491 “Cosmic Interacting Matters - From Source to Signal”. KMH acknowledges financial support from the State Agency for Research of the Spanish Ministry of Science, Innovation and Universities through the “Center of Excellence Severo Ochoa” awarded to the Instituto de Astrofísica de Andalucía (SEV-2017-0709), from the coordination of the participation in SKA-SPAIN, funded by the Ministry of Science and Innovation (MCIN). OMB and JvL acknowledge funding from NWO under the Vici research program “ARGO” with project number 639.043.815. Y.M., L.C.O., R.S. and J.vL. acknowledge funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 617199 (“ALERT”). IPM acknowledges funding from the Netherlands Research School for Astronomy (grant no. NOVA5-NW3-10.3.5.14). A.A.P. acknowledges support of the STFC consolidated grant ST/S000488/1. DV acknowledges support from the Netherlands eScience Center (NLeSC) under grant ASDI.15.406. This research has made use of NASA’s Astrophysics Data System Bibliographic Services and Astropy, (http://www.astropy.org) a community-developed core Python package for Astronomy (Astropy Collaboration 2013, 2018).

Published
2022

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