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This paper is concerned with a discussion of a method of manufacture for tablet granulations in which active ingredients comprise a major portion of the tablet. The method involves the use of standard coating pans in which granulations are formed by spraying with starch paste or other commonly used granulating solutions and subsequent drying in the pan.

An apparatus for determining dissolution rates of soluble tablets is described. The importance of control of agitation in dissolution rate determination is shown. The instrument described can be closely controlled in this factor, and dissolution rate results achieved with it are more accurate and reproducible than those obtainable when operator judgment governs inversion rate.