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Проблема лечения тяжелых пневмоний, в том числе и вирусных (вирусно-бактериальных), сохраняет свою высокую актуальность и требует внедрения алгоритма клинико-диагностических мероприятий для обеспечения адекватной лечебной тактики в данной нозологической группе. В статье рассмотрен клинический случай интенсивной терапии пациента с внегоспитальной двусторонней полисегментарной пневмонией.

Елена Викторовна Корнеева, кандидат технических наук, доцент кафедры строительных технологий и материалов, Сибирский государственный индустриальный университет (Новокузнецк), korneev_va@list.ru Геннадий Ильич Бердов, доктор технических наук, профессор, Новосибирский государственный архитектурно-строительный университет (Новосибирск). E.V. Korneeva1, korneev_va@list.ru G.I. Berdov2 1 Siberian State Industrial University, Novokuznetsk, Russian Federation 2 Novosibirsk State University of Architecture and Civil Engineering, Novosibirsk, Russian Federation

The molecular properties of oxypropyl cellulose acetate (APC) with an average molar degree of substitution DS = 2.25 were investigated by flow birefringence, sedimentation, diffusion and viscometry. In the range of molecular weight (M) from 3 · 103 to 202 · 103, the relationships between intrinsic viscosity, sedimentation and diffusion coefficients and M were established. The length of a statistical Kuhn segment A = (180 ± 10) A and the diameter of the molecule d = (17 ± 3) A were calculated from hydrodynamic data with the application of the worm-like chain model. The optical anisotropy of the molecular segment is positive (400 · 10−25cm3). The dependence of the shear optical coefficient [ n] [n ] on M was used for determination of the equilibrium rigidity of molecules. The optical data gave the segment length AFB = (170 ± 10) A in agreement with the above value of A. The data were compared to the characteristics of cellulose esters and other ethers with similar structures.

The rationale for the present study is explained by a high spread of metabolic syndrome among the young population, living in an area equivalent to the Far North. The study is aimed at the investigation of the association between a deletion allele of the polymorphism of deletion/insertion in the αIIbβ3 integrin gene and metabolic syndrome in young residents Khanty-Mansiysk Autonomous Okrug – Ugra (Russia). The 758 young people aged 18-44 (mean age 36.62±5.12 years old) with metabolic syndrome and 77 healthy young people without metabolic disorders were examined. The carriership of the allele I associated with the cardiovascular risk was revealed in 63% of the examined patients that had an increased risk of the development of metabolic disorders (OR 1.409, 95% CI 0.858-2.311, p=0.253). There was no significant difference between the native and non-native populations in the rate of occurrence of allele I (62.2% and 64.7%). Genotype II had significant association with arterial hypertension (OR 1.377, 95 % CI 0.912-2.080, p=0.073), obesity (OR 1.353, 95% CI 0.825-2.219, p=0.071), hypercholesterinemia (OR 1.386, 95% CI 0.977-1.966, p=0.115), hypertriglyceridemia (OR 1.232, 95% CI 0.889-1.706, p=0.097). It was established that the non-native population had a higher risk of the development of abdominal obesity, arterial hypertension, and hypercholesterinemia, unlike the native population that had a significantly higher risk of the development of triglyceridemia. The materials of the article can be useful for the evaluation of genetic predisposition to myocardial infarction, stroke, and thromboembolism, which will allow for timely indication of preventive measures.