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1. Eating attitudes of migraine patients in Turkey: a prospective multi-center study

Author

Ocal, Ruhsen, Karakurum-Goksel, Basak, Van, Mert, Coskun, Ozlem, Karaaslan, Cihad, Ucler, Serap, Gokcay, Figen, Celebisoy, Nese, Sirin, Hadiye, Kisabay Ak, Aysin, Saritas, Aysegul Seyma, Cerrahoglu Sirin, Tuba, Hasirci Bayir, Buse Rahime, Ekizoglu, Esme, Orhan, Elif Kocasoy, Bayram, Derya, Tanik, Nermin, Bicakci, Sebnem, Ozturk, Vesile, Inan, Levent Ertugrul, Metin, Kubra Mehel, Eren, Yasemin, Dora, Babur, Oguz-Akarsu, Emel, Karli, Necdet, Celik, Emel Ur, Atalar, Arife Cimen, Gozubatik Celik, Rabia Gokcen, Mutluay, Belgin, Aydinlar, Elif Ilgaz, Yalinay Dikmen, Pinar, Semercioglu, Sencer, Emre, Ufuk, Buldukoglu, Osman Cagin, Er, Busra, Kilboz, Bekir Burak, Ibis, Seray, Yagiz, Sibgetullah, Koklu, Huzeyfe, Kamaci, Ibrahim, Aliyeva, Gulshan, Ates, Basak Elcin, Kara, Muge Mercan, Altunc, Fatma Zehra, Kaya, Ilgin, and Sisman, Cagla

Published
2024
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2. miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis

Author

Edgünlü, Tuba Gökdogan, Yilmaz, ?‡enay Gorücü, Emre, Ufuk, Tasdelen, Bahar, Kuru, Oktay, Kutlu, Gülnihal, and Erdal, Mehmet Emin

Subjects
Identification and classification, Analysis, Genetic aspects, Properties, Methods, Epigenetic inheritance -- Analysis, MicroRNA -- Identification and classification -- Genetic aspects -- Properties, Polymerase chain reaction -- Methods -- Analysis, Multiple sclerosis -- Genetic aspects, Biological markers -- Analysis
Abstract

Introduction Multiple sclerosis (MS) is a demyelination disease mediated by the immune system and is characterized by pathological mechanisms originating from the autoimmune destruction of myelin and neurons in the [...], Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS pathology. In this cohort study, differential expression of the four miRNAs (hsa-miR-155-5p, hsa-miR-9-5p, hsa-miR-181a-5p, and hsa-miR-125b-5p) was investigated in 69 individuals, including 39 MS patients (relapsing-remitting MS (RRMS), n = 27; secondary progressive MS (SPMS), n = 12) and 30 healthy controls. In silico analyses revealed possible genes and pathways specific to miRNAs. Peripheral blood miRNA expressions were detected by quantitative real-time PCR (qPCR). hsa-miR-181a-5p was downregulated and associated with increased MS risk (P = 0.012). The other three miRNAs were upregulated and not associated with MS (P < 0.05). The area under the curve (AUC) is 0.779. In silico analyses showed that hsa-miR-181a-5p may participate in MS pathology by targeting MAP2K1, CREB1, ATXN1, and ATXN3 genes in inflammation and neurodegeneration pathways. The circulatory hsa-miR-181a-5p can regulate target genes, reversing the mechanisms involved in MS pathologies such as protein uptake and processing, cell proliferation and survival, inflammation, and neurodegeneration. Thus, this miRNA could be used as an epigenomic-guided diagnostic tool and for therapeutic purpose. Key words: multiple sclerosis, miRNA biomarkers, peripheral blood molecular diagnostics La sclérose en plaques (SP) est une maladie inflammatoire chronique du système nerveux central (SNC) caractérisée par une démyélinisation et une dégénérescence axonale. L&apos;expression anormale des microARN (miARN) joue un rôle important dans cette pathologie. Dans cette étude de cohorte, l&apos;expression différentielle de quatre miRNA (hsa-miR-155-5p, hsa-miR-9-5p, hsa-miR-181a-5p et hsa-miR-125b-5p) a été examinée chez 69 individus dont 39 patients SP (forme récurrente-rémittente, SPRR ; n =27 ; ou forme progressive secondaire, SPPS ; n =12) et 30 témoins en santé. Des analyses in silico ont révélé de possibles gènes ou sentiers spécifiques aux miARN. L&apos;expression des miARN dans le sang périphérique a été mesurée par PCR quantitatif en temps réel (qPCR). Le hsa-miR-181a-5p était moins fortement exprimé et il était associé à un risque accru de SP (P = 0,012). Les trois autres miARN étaient plus fortement exprimés chez les patients SP et n&apos;étaient pas associés à la SP (P < 0,05). L&apos;aire sous la courbe (AUC) était de 0,779. Des analyses in silico ont également montré que le hsa-miR-181a-5p pourrait participer à la pathologie de la SP en ciblant les gènes MAP2K1, CREB1, ATXN1 et ATXN3 des sentiers de l&apos;inflammation et de la neurodégénérescence. Les hsa-miR-181a-5p en circulation peuvent réguler les gènes ciblés, renversant les mécanismes impliqués dans les pathologies liées à la SP telles que l&apos;absorption et la transformation des protéines, la prolifération cellulaire et la survie, l&apos;inflammation et la neurodégénérescence. Ainsi, ce miARN pourrait servir d&apos;outil diagnostique épigénomique et thérapeutique. [Traduit par la Rédaction] Mots-clés : sclérose en plaques, miARN biomarqueurs, diagnostic moléculaire du sang périphérique

Published
2022
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10. Acute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study

Author

Topçuoğlu, Mehmet Akif, primary, Özdemir, Atilla Özcan, additional, Arsava, Ethem Murat, additional, Güneş, Aygül, additional, Aykaç, Özlem, additional, Sarıönder Gencer, Elif, additional, Çabalar, Murat, additional, Yayla, Vildan, additional, Erdoğan, Hacı Ali, additional, Erdoğan, Mücahid, additional, Özdemir Acar, Zeynep, additional, Giray, Semih, additional, Kablan, Yüksel, additional, Tanrıverdi, Zeynep, additional, Yalaz Tekan, Ülgen, additional, Asil, Talip, additional, Akpınar, Çetin Kürşad, additional, Yürekli, Vedat Ali, additional, Acar, Bilgehan, additional, Şirin, Hadiye, additional, Güler, Ayşe, additional, Baydemir, Recep, additional, Akçakoyunlu, Merve, additional, Öcek, Levent, additional, Çetiner, Mustafa, additional, Nazlıel, Bijen, additional, Çağlayan, Hale Batur, additional, Ongun, Nedim, additional, Eren, Alper, additional, Arlıer, Zülfikar, additional, Cenikli, Utku, additional, Gökçe, Mustafa, additional, Bavli, Songül, additional, Yaka, Erdem, additional, Özkul, Ayça, additional, Değirmenci, Bahar, additional, Aluçlu, Ufuk, additional, Togay Işıkay, Canan, additional, Aslanbaba, Eda, additional, Sorgun, Mine, additional, Aytaç, Emrah, additional, Ay, Halil, additional, Kunt, Refik, additional, Şenadım, Songül, additional, Özüm Ünsal, Yaprak, additional, Eşkut, Neslihan, additional, Alioğlu, Zekeriya, additional, Yılmaz, Arda, additional, Genç, Hamit, additional, Yılmaz, Ayşe, additional, Milanoğlu, Aysel, additional, Gürkaş, Erdem, additional, Değirmenci, Eylem, additional, Bektaş, Hesna, additional, İlgezdi, İrem, additional, Bilgiç, Adnan Burak, additional, Akyol, Şenol, additional, Güngör, Levent, additional, Kale, Nilüfer, additional, Çoban, Eda, additional, Yeşilot, Nilüfer, additional, Ekizoğlu, Esme, additional, Kizek, Özgü, additional, Kurşun, Oğuzhan, additional, Kayım Yıldız, Özlem, additional, Bolayır, Aslı, additional, Kısabay, Aysın, additional, Baştan, Birgül, additional, Acar, Zeynep, additional, Niflioğlu, Buket, additional, Güven, Bülent, additional, Kaya, Dilaver, additional, Afşar, Nazire, additional, Yazıcı, Duran, additional, Toplutaş, Eren, additional, Özkan, Esra, additional, İlik, Faik, additional, İnce, Fatma Birsen, additional, Büyükşerbetçi, Gülseren, additional, Önder, Halil, additional, Karadeli, Hasan Hüseyin, additional, Kozak, Hasan Hüseyin, additional, Demirbaş, Hayri, additional, Midi, İpek, additional, Aydın, İsa, additional, Epçeliden, M. Tuncay, additional, Atmaca, Murat Mert, additional, Bakar, Mustafa, additional, Şen, Mustafa, additional, Turgut, Nilda, additional, Keskin, Onur, additional, Akdoğan, Özlem, additional, Emre, Ufuk, additional, Bilgili, Özlem, additional, Bekdik Şirinocak, Pınar, additional, Yevgi, Recep, additional, Yazıcı Akkaş, Sinem, additional, Yoldaş, Tahir, additional, Duman, Taşkın, additional, Özel, Tuğba, additional, Ünal, Ali, additional, Dora, Babür, additional, Atasoy, Tuğrul, additional, Piri Çınar, Bilge, additional, Demir, Tülin, additional, Demir, Turgay, additional, Can, Ufuk, additional, Aslan, Yıldız, additional, Baş, Demet Funda, additional, Şener, Ufuk, additional, Yılmaz, Zahide, additional, Bozdoğan, Zehra, additional, Özdemir, Gökhan, additional, Krespi, Yakup, additional, and Öztürk, Şerefnur, additional

Published
2023
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12. Atrial Fibrillation Management in Acute Stroke Patients in Türkiye: Real-life Data from the NöroTek Study

Author

Topçuoğlu, Mehmet Akif, primary, Arsava, Ethem Murat, additional, Özdemir, Atilla Özcan, additional, Aykaç, Özlem, additional, Çetiner, Mustafa, additional, Sarıönder Gencer, Elif, additional, Güneş, Aygül, additional, Krespi, Yakup, additional, Yaka, Erdem, additional, Öcek, Levent, additional, Tanrıverdi, Zeynep, additional, Yalaz Tekan, Ülgen, additional, Özkul, Ayça, additional, Özkan, Esra, additional, Şirin, Hadiye, additional, Güler, Ayşe, additional, Kurşun, Oğuzhan, additional, Kunt, Refik, additional, Cenikli, Utku, additional, Acar, Bilgehan, additional, Kablan, Yüksel, additional, Yılmaz, Ayşe, additional, Işıkay, Canan Togay, additional, Aslanbaba, Eda, additional, Sorgun, Mine, additional, Bektaş, Hesna, additional, Çabalar, Murat, additional, Yayla, Vildan, additional, Erdoğan, Hacı Ali, additional, Gökçe, Mustafa, additional, Bavli, Songül, additional, Ongun, Nedim, additional, Keskin, Ahmet Onur, additional, Akdoğan, Özlem, additional, Emre, Ufuk, additional, Kayım Yıldız, Özlem, additional, Bolayır, Aslı, additional, Akpınar, Çetin Kürşad, additional, Karadeli, Hasan Hüseyin, additional, Özel, Tuğba, additional, Ünal, Ali, additional, Dora, Babür, additional, Arlıer, Zülfikar, additional, Eren, Alper, additional, Milanoğlu, Aysel, additional, Nazliel, Bijen, additional, Batur Çağlayan, Hale, additional, Güven, Bülent, additional, Erdoğan, Mücahid, additional, Özdemir Acar, Zeynep, additional, Bakar, Mustafa, additional, Giray, Semih, additional, Şenadım, Songül, additional, Asil, Talip, additional, Demir, Turgay, additional, Özüm Ünsal, Yaprak, additional, Eşkut, Neslihan, additional, Baştan, Birgül, additional, Acar, Zeynep, additional, Niflioğlu, Buket, additional, Yazıcı, Duran, additional, Aytaç, Emrah, additional, İnce, Fatma Birsen, additional, Ay, Halil, additional, Önder, Halil, additional, Kozak, Hasan Hüseyin, additional, İlgezdi, İrem, additional, Bilgiç, Adnan Burak, additional, Akyol, Şenol, additional, Güngör, Levent, additional, Atmaca, Murat Mert, additional, Şen, Mustafa, additional, Yevgi, Recep, additional, Yazıcı Akkaş, Sinem, additional, Yoldaş, Tahir, additional, Atasoy, H. Tuğrul, additional, Çınar, Bilge Piri, additional, Yılmaz, Arda, additional, Genç, Hamit, additional, Kısabay, Ayşın, additional, İlik, Faik, additional, Demirbaş, Hayri, additional, Midi, İpek, additional, Bekdik Şirinocak, Pınar, additional, Duman, Taşkın, additional, Demir, Tülin, additional, Can, Ufuk, additional, Yürekli, Vedat Ali, additional, Bozdoğan, Zehra, additional, Alioğlu, Zekeriya, additional, Kaya, Dilaver, additional, Afşar, Nazire, additional, Gürkaş, Erdem, additional, Toplutaş, Eren, additional, Değirmenci, Eylem, additional, Büyükşerbetçi, Gülseren, additional, Aydın, İsa, additional, Epçeliden, M. Tuncay, additional, Turgut, Nilda, additional, Kale, Nilüfer, additional, Çoban, Eda, additional, Yeşilot, Nilüfer, additional, Ekizoğlu, Esme, additional, Kizek, Özgü, additional, Bilgili, Özlem, additional, Baydemir, Recep, additional, Akçakoyunlu, Merve, additional, Yılmaz, Zahide, additional, and Öztürk, Şerefnur, additional

Published
2023
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16. Gastrostomy in Hospitalized Patients with Acute Stroke: “NöroTek” Turkey Point Prevalence Study Subgroup Analysis

Author

Topçuoğlu, Mehmet Akif, primary, Özdemir, Atilla Özcan, additional, Aykaç, Özlem, additional, Milanoğlu, Aysel, additional, Gökçe, Mustafa, additional, Bavli, Songül, additional, Çabalar, Murat, additional, Yayla, Vildan, additional, Erdoğan, Hacı Ali, additional, Özkul, Ayça, additional, Güneş, Aygül, additional, Değirmenci, Bahar, additional, Aluçlu, Ufuk, additional, Kozak, Hasan Hüseyin, additional, Güngör, Levent, additional, Erdoğan, Mücahid, additional, Özdemir Acar, Zeynep, additional, Cenikli, Utku, additional, Kablan, Yüksel, additional, Yılmaz, Arda, additional, Genç, Hamit, additional, Nazliel, Bijen, additional, Batur Çağlayan, Hale, additional, Sarıönder Gencer, Elif, additional, Ay, Halil, additional, Demirbaş, Hayri, additional, Akdoğan, Özlem, additional, Emre, Ufuk, additional, Kayım Yıldız, Özlem, additional, Bolayır, Aslı, additional, Demir, Turgay, additional, Tanrıverdi, Zeynep, additional, Yalaz Tekan, Ülgen, additional, Akpınar, Çetin Kürşad, additional, Özkan, Esra, additional, İlik, Faik, additional, Şirin, Hadiye, additional, Güler, Ayşe, additional, Önder, Halil, additional, Bektaş, Hesna, additional, Öcek, Levent, additional, Bakar, Mustafa, additional, Ongun, Nedim, additional, Krespi, Yakup, additional, Togay Işıkay, Canan, additional, Aslanbaba, Eda, additional, Sorgun, Mine, additional, Gürkaş, Erdem, additional, Karadereli, Hasan Hüseyin, additional, Midi, İpek, additional, İlgezdi, İrem, additional, Bilgiç, Adnan Burak, additional, Akyol, Şener, additional, Epçeliden, M. Tuncay, additional, Atmaca, Murat Mert, additional, Kurşun, Oğuzhan, additional, Keskin, Onur, additional, Bekdik Şirinocak, Pınar, additional, Baydemir, Recep, additional, Akçakoyunlu, Merve, additional, Öztürk, Şerefnur, additional, Özel, Tuğba, additional, Ünal, Ali, additional, Dora, Babür, additional, Yürekli, Vedat Ali, additional, Arlıer, Zülfikar, additional, Eren, Alper, additional, Yılmaz, Ayşe, additional, Kısabay, Ayşin, additional, Acar, Bilgehan, additional, Baştan, Birgül, additional, Acar, Zeynep, additional, Niflioğlu, Buket, additional, Güven, Bülent, additional, Kaya, Dilaver, additional, Afşar, Nazire, additional, Yazıcı, Duran, additional, Aytaç, Emrah, additional, Yaka, Erdem, additional, Toplutaş, Eren, additional, Değirmenci, Eylem, additional, İnce, Fatma Birsen, additional, Büyükşerbetçi, Gülseren, additional, Aydın, İsa, additional, Çetiner, Mustafa, additional, Şen, Mustafa, additional, Turgut, Nilda, additional, Kale, Nilüfer, additional, Çoban, Eda, additional, Yeşilot, Nilüfer, additional, Ekizoğlu, Esme, additional, Kizek, Özgü, additional, Birgili, Özlem, additional, Yevgi, Recep, additional, Kunt, Refik, additional, Giray, Semih, additional, Yazıcı Akkaş, Sinem, additional, Şenadım, Songül, additional, Yoldaş, Tahir, additional, Asil, Talip, additional, Duman, Taşkın, additional, Atasoy, Tuğrul, additional, Piri Çınar, Bilge, additional, Demir, Tülin, additional, Can, Ufuk, additional, Özüm Ünsal, Yaprak, additional, Eşkut, Neslihan, additional, Aslan, Yıldız, additional, Baş, Demet Funda, additional, Şener, Ufuk, additional, Yılmaz, Zahide, additional, Bozdoğan, Zehra, additional, Alioğlu, Zekeriya, additional, and Arsava, Ethem Murat, additional

Published
2022
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18. Gastrostomy in Hospitalized Patients with Acute Stroke: NoroTek Turkey Point Prevalence Study Subgroup Analysis

Author

Topçuoğlu, Mehmet Akif, Özdemir, Atilla Özcan, Aykaç, Özlem, Milanoğlu, Aysel, Gökçe, Mustafa, Bavli, Songül, Çabalar, Murat, Yayla, Vildan, Erdoğan, Haci Ali, Özkul, Ayça, Güneş, Aygül, Değirmenci, Bahar, Aluçlu, Ufuk, Kozak, Hasan Hüseyin, Güngör, Levent, Erdoğan, Mücahid, Özdemir Acar, Zeynep, Cenikli, Utku, Kablan, Yüksel, Yılmaz, Arda, Genç, Hamit, Nazliel, Bijen, Çaglayan, Hale Batur, Sarıönder Gencer, Elif, Ay, Halil, Demirbaş, Hayri, Akdoğan, Özlem, Emre, Ufuk, Kayım Yıldız, Özlem, Bolayır, Aslı, Demir, Turgay, Tanrıverdi, Zeynep, Tekan, Ulgen Yalaz, Akpınar, Çetin Kürşad, Özkan, Esra, Ilık, Faik, Şirin, Hadiye, Güler, Ayşe, Önder, Halil, Bektaş, Hesna, Ocek, Levent, Bakar, Mustafa, Ongün, Nedim, Krespi, Yakup, Işıkay, Canan Togay, Aslanbaba, Eda, Sorgun, Mine, Gürkas, Erdem, Karadeli, Hasan Hüseyin, Midi, İpek, Ilgezdı, İrem, Bilgiç, Adnan Burak, Akyol, Şener, Epceliden, M. Tuncay, Atmaca, Murat Mert, Kurşun, Oğuzhan, Keskin, Onur, Bekdik Şirinocak, Pınar, Baydemir, Recep, Akcakoyunlu, Merve, Öztürk, Şerefnur, Özel, Tuğba, Ünal, Ali, Dora, Babur, Yürekli, Vedat Ali, Arlıer, Zülfikar, Eren, Alper, Yılmaz, Ayşe, Kısabay, Ayşin, Acar, Bilgehan, Baştan, Birgül, Acar, Zeynep, Niflioğlu, Buket, Güven, Bülent, Kaya, Dilaver, Afşar, Nazire, Yazıcı, Duran, Aytaç, Emrah, Yaka, Erdem, Toplutaş, Eren, Değirmenci, Eylem, İnce, Fatma Birsen, Büyükşerbetçi, Gülseren, Aydın, İsa, Çetiner, Mustafa, Şen, Mustafa, Turgut, Nilda, Kale, Nilüfer, Çoban, Eda, Yeşilot, Nilüfer, Ekizoğlu, Esme, Kızek, Özgü, Birgili, Özlem, Yevgi, Recep, Kunt, Refik, Giray, Semih, Yazıcı Akkaş, Sinem, Şenadım, Songül, Yoldaş, Tahir, Asil, Talip, Duman, Taşkın, Atasoy, Tuğrul, Çınar, Bilge Piri, Demir, Tülin, Can, Ufuk, Ünsal, Yaprak Özüm, Eskut, Neslihan, Aslan, Yıldız, Baş, Demet Funda, Şener, Ufuk, Yılmaz, Zahide, Bozdoğan, Zehra, Alioğlu, Zekeriya, Arsava, Ethem Murat, and Acibadem University Dspace

Subjects
İnme, dysphagia, Predictors, Malnutrition, Tube Placement, Dysphagia, malnutrition, Guidelines, Flash Mob, Intracerebral Hemorrhage, intracerebral hemorrhage, Trial, Intraserebral Kanama, Stroke, Anda Güruh, Percutaneous Endoscopic Gastrostomy, Disfaji, Food, Neurology (clinical), flash mob, Malnütrisyon
Abstract

Objective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NöroTek is a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients [female: 53%, age: 69±14; acute ischemic stroke in 845; intracerebral hematoma (ICH) in 119 and post-resuscitation encephalopathy (PRE) in 8] with complete data were included in this sub-study. Results: Gastrostomy was inserted in 10.7% of the patients with ischemic stroke, 10.1% of the patients with ICH and in 50% of the patients with PRE. Independent predictors of percutaneous endoscopic gastrostomy (PEG) administration were The National Institutes of Health Stroke Scale score at admission [exp (β): 1.09 95% confidence interval (CI): 1.05-1.14, per point] in ischemic stroke; and mechanical ventilation in ischemic [exp (β): 6.18 (95% CI: 3.16-12.09)] and hemorrhagic strokes [exp (β): 26.48 (95% CI: 1.36-515.8)]. PEG was found to be a significant negative indicator of favorable (modified Rankin’s scale score 0-2) functional outcome [exp (β): 0.032 (95% CI: 0.004-0.251)] but not of in-hospital mortality [exp (β): 1.731 (95% CI: 0.785-3.829)]. Nutritional and swallowing assessments were performed in approximately two-thirds of patients. Of the nutritional assessments 69% and 76% of dysphagia assessments were completed within the first 2 days. Tube feeding was performed in 39% of the patients. In 83.5% of them, tube was inserted in the first 2 days; 28% of the patients with feeding tube had PEG later. Conclusion: The NöroTek study provided the first reliable and large-scale data on key quality metrics of nutrition practice in acute stroke in Turkey. In terms of being economical and accurate it makes sense to use the point prevalence method. Amaç: Akut nörovasküler hastalıklarda nütrisyonel durum ve disfaji değerlendirmesi ve enteral beslenme kararı önemli prognoz belirleyicilerindendir. Gereç ve Yöntem: NöroTek, 10 Mayıs 2018’de (Dünya İnme Farkındalık Günü) Türkiye’nin tüm sağlık alt bölgelerine yayılmış 87 hastanenin katılımıyla gerçekleştirilen bir nokta prevalans çalışmasıdır. Hastanede yatan ve bu alt çalışma için toplanan verisi tam olan toplam 972 nörovasküler hasta (kadın: %53, yaş: 69±14 yıl; 845’i akut iskemik inme; 119’u intraserebral hematom ve 8’i post-resüsitasyon ensefalopatisi) analiz edildi. Bulgular: Gastrostomi iskemik inmeli hastaların %10,7, intraserebral kanamalıların %10,1 ve post-resusitasyon ensefalopatisi olanların %50’sine uygulanmıştır. Perkütan endoskopik gastrostomi (PEG) gereksiniminin bağımsız belirleyicileri, iskemik inme grubunda kabul NIHSS [exp (β): 1,09, %95 güven aralığı (GA): 1,05-1,14, puan başına] ile hem iskemik hem de hemorajik inmelerde mekanik ventilasyon uygulanmış olmasıdır [iskemik için: exp (β): 6,18, %95 GA: 3,16- 12,09] ve hemorajik inme için: [exp (β): 26,48, 95% GA: 1,36-515,8]. İnme olgularında PEG uygulaması hastane içi mortalite için bağımsız belirleyici değildi [exp (β): 1,731, 95% GA: 0,785-3,829]. Ancak, PEG uygulanmış olması taburculuk esnasında iyi prognoza (modifiye Rankin skoru 0-2) sahip olabilme için anlamlı bir negatif etmen olarak bulundu [exp (β): 0,032, %95 GA: 0,004-0,251]. Hastanede yatan nörovasküler hastaların yaklaşık üçte ikisinde malnütrisyon ve yutma bozukluğu açısından değerlendirme yapılmıştı. Nutrisyonel status değerlendirmesinin %69’u ve disfaji değerlendirmesinin %76’sı ilk 48 saat içinde gerçekleştirilmişti. Tüple enteral nütrisyon uygulama oranı %39’du. Beslenme tüplerinin %83,5’i ilk 2 gün içinde yerleştirilirken beslenme tüpü olan hastaların %28’ine daha sonra PEG açılmıştı. Sonuç: NöroTek çalışması ile Türkiye’de hastanede yatan akut inme hastalarında nutrisyonel uygulamaların temel kalite ölçütlerine ilişkin ilk güvenilir ve büyük ölçekli veri sağlanmıştır. Ekonomik olması ve doğruluğu açısından nokta yaygınlık yönteminin bu tip verilerin temini için daha fazla kullanılması mantıklıdır.

Published
2022

23. Türkiye'de inme hastalarında atrial fibrilasyon ve yönetimi: Nörotek Çalışması gerçek hayat verileri (S-011)

Author

ÇETİNER, MUSTAFA, ÖZDEMİR, ATİLLA ÖZCAN, ARSAVA, ETHEM MURAT, TOPÇUOĞLU, MEHMET AKİF, AYDIN, İSA, BOZDOĞAN ŞENEL, ZEHRA, YÜREKLİ, VEDAT ALİ, CAN, UFUK, DEMİR, TÜLİN, DUMAN, TAŞKIN, BEKDİK ŞİRİNOCAK, PINAR, MİDİ, İPEK, DEMİRBAŞ, HAYRİ, İLİK, FAİK, KISABAY, AYŞİN, GENÇ, HAMİD, YILMAZ, İBRAHİM ARDA, PİRİ ÇİNAR, BİLGE, ATASOY, HÜSEYİN TUĞRUL, YOLDAŞ, TAHİR KURTULUŞ, YAZICI AKKAŞ, SİNEM, YEVGİ, RECEP, ŞEN, MUSTAFA, ATMACA, MURAT MERT, GÜNGÖR, İBRAHİM LEVENT, AKYOL, ŞENOL, BİLGİÇ, ADNAN BURAK, İLGEZDİ, İREM, KOZAK, HASAN HÜSEYİN, ÖNDER, HALİL, AY, HALİL, İNCE, FATMA BİRSEN, AYTAÇ, EMRAH, YAZICI, DURAN, NİFTİOĞLU, BUKET, ACAR, ZEYNEP, BAŞTAN TÜZÜN, BİRGÜL, ALUÇLU, MEHMET UFUK, DEGİRMENCİ, BAHAR, ŞENER, UFUK, BAŞ SÖKMEZ, DEMET FUNDA, ASLAN, YILDIZ, EŞKUT, NESLİHAN, ÜNSAL, YAPRAK ÖZÜM, DEMİR, TURGAY, ASIL, TALİP, ŞENADIM, SONGÜL, GİRAY, SEMİH, BAKAR, HACI MUSTAFA, ÖZDEMİR ACAR, ZEYNEP, ERDOĞAN, MÜCAHİD, GÜVEN, BÜLENT, BATUR ÇAĞLAYAN, HALE ZEYNEP, NAZLIEL, BİJEN, MİLANLIOĞLU, AYSEL, EREN, ALPER, ARLIER, ZÜLFİKAR, DORA, BABÜR, ÜNAL, ALİ, ÖZEL, TUĞBA, KARADELİ, HASAN HÜSEYİN, AKPINAR, ÇETİN KÜRŞAD, BOLAYIR, ASLI, KAYIM YILDIZ, ÖZLEM, EMRE, UFUK, AKDOĞAN, ÖZLEM, KESKİN, AHMET ONUR, ONGUN, NEDİM, BAVLİ, SONGÜL, GÖKÇE, MUSTAFA, ERDOĞAN, HACI ALİ, YAYLA, VİLDAN AYŞE, ÇABALAR, MURAT, BEKTAŞ, HESNA, SORGUN, MİNE HAYRİYE, ASLANBABA BAHADIR, EDA, TOGAY IŞIKAY, CANAN, YILMAZ, AYŞE, KABLAN, YÜKSEL, ACAR, BİLGEHAN ATILGAN, CENİKLİ, UTKU, KUNT, REFİK, KURŞUN, OĞUZHAN, GÜLER, AYŞE, ŞİRİN, HADİYE, ÖZKAN, ESRA, ÖZKUL, AYÇA, YALAZ TEKAN, ÜLGEN, TANRIVERDİ, ZEYNEP, ÖCEK, LEVENT, YAKA, ERDEM, KRESPİ, YAKUP, GÜNEŞ, AYGÜL, SARIÖNDER GENCER, ELİF, ALİOĞLU, ZEKERİYA, KAYA, DİLAVER, AFŞAR, NAZİRE, GÜRKAŞ, ERDEM, TOPLUTAŞ, EREN, DEĞİRMENCİ, EYLEM, and BÜYÜKŞERBETCİ, GÜLSEREN

Published
2020

24. Nöroloji klinik pratiğinde PEG: Nörotek Türkiye planlı subgrup analizi (S-012)

Author

TOPÇUOĞLU, MEHMET AKİF, ARSAVA, ETHEM MURAT, ALİOĞLU, ZEKERİYA, BOZDOĞAN ŞENEL, ZEHRA, YILMAZ, ZAHİDE, ŞENER, UFUK, BAŞ SÖKMEZ, DEMET FUNDA, ASLAN, YILDIZ, EŞKUT, NESLİHAN, ÜNSAL, YAPRAK ÖZÜM, CAN, UFUK, DEMİR, TÜLİN, PİRİ ÇİNAR, BİLGE, ATASOY, HÜSEYİN TUĞRUL, DUMAN, TAŞKIN, ASIL, TALİP, YOLDAŞ, TAHİR KURTULUŞ, ŞENADIM, SONGÜL, YAZICI AKKAŞ, SİNEM, GİRAY, SEMİH, KUNT, REFİK, YEVGİ, RECEP, BİLGİLİ, ÖZLEM, KİZEK, ÖZGÜ, EKİZOĞLU TURGUT, ESME, YEŞİLOT, NİLÜFER, ÇOBAN, EDA, KALE İÇEN, NİLÜFER, TURGUT, NİLDA, ŞEN, MUSTAFA, ÇETİNER, MUSTAFA, AYDIN, İSA, BÜYÜKŞERBETCİ, GÜLSEREN, İNCE, FATMA BİRSEN, DEĞİRMENCİ, EYLEM, TOPLUTAŞ, EREN, AYTAÇ, EMRAH, YAZICI, DURAN, AFŞAR, NAZİRE, KAYA, DİLAVER, GÜVEN, BÜLENT, NİFTİOĞLU, BUKET, ACAR, ZEYNEP, BAŞTAN TÜZÜN, BİRGÜL, ACAR, BİLGEHAN ATILGAN, KISABAY, AYŞİN, YILMAZ, AYŞE, EREN, ALPER, ARLIER, ZÜLFİKAR, YÜREKLİ, VEDAT ALİ, DORA, BABÜR, ÜNAL, ALİ, ÖZEL, TUĞBA, ÖZTÜRK, ŞEREFNUR, AKCAKOYUNLU, MERVE, BAYDEMİR, RECEP, BEKDİK ŞİRİNOCAK, PINAR, KESKİN, AHMET ONUR, KURŞUN, OĞUZHAN, ATMACA, MURAT MERT, EPÇELİDEN, MECİT TUNCAY, AKYOL, ŞENOL, BİLGİÇ, ADNAN BURAK, İLGEZDİ, İREM, MİDİ, İPEK, KARADELİ, HASAN HÜSEYİN, GÜRKAŞ, ERDEM, SORGUN, MİNE HAYRİYE, ASLANBABA BAHADIR, EDA, TOGAY IŞIKAY, CANAN, KRESPİ, YAKUP, ONGUN, NEDİM, BAKAR, HACI MUSTAFA, ÖCEK, LEVENT, BEKTAŞ, HESNA, ÖNDER, HALİL, GÜLER, AYŞE, ŞİRİN, HADİYE, İLİK, FAİK, ÖZKAN, ESRA, AKPINAR, ÇETİN KÜRŞAD, YALAZ TEKAN, ÜLGEN, TANRIVERDİ, ZEYNEP, DEMİR, TURGAY, BOLAYIR, ASLI, KAYIM YILDIZ, ÖZLEM, EMRE, UFUK, AKDOĞAN, ÖZLEM, DEMİRBAŞ, HAYRİ, AY, HALİL, SARIÖNDER GENCER, ELİF, BATUR ÇAĞLAYAN, HALE ZEYNEP, NAZLIEL, BİJEN, GENÇ, HAMİD, YILMAZ, İBRAHİM ARDA, KABLAN, YÜKSEL, CENİKLİ, UTKU, ÖZDEMİR ACAR, ZEYNEP, ERDOĞAN, MÜCAHİD, GÜNGÖR, İBRAHİM LEVENT, KOZAK, HASAN HÜSEYİN, ALUÇLU, MEHMET UFUK, DEGİRMENCİ, BAHAR, GÜNEŞ, AYGÜL, ÖZKUL, AYÇA, ERDOĞAN, HACI ALİ, YAYLA, VİLDAN AYŞE, ÇABALAR, MURAT, BAVLİ, SONGÜL, GÖKÇE, MUSTAFA, MİLANLIOĞLU, AYSEL, AYKAÇ, ÖZLEM, YAKA, ERDEM, and ÖZDEMİR, ATİLLA ÖZCAN

Published
2020

25. NÖROLOJİ KLİNİK PRATİĞİNDE PEG: NÖROTEKTÜRKİYE PLANLI SUBGRUP ANALİZİ

Author

Niftioğlu, Buket, ACAR, ZEYNEP, GÜVEN, BÜLENT, AYKAÇ, ÖZLEM, KAYA, DİLAVER, AFŞAR FAK, NAZİRE EFSER YEŞİM, DURAN, YAZICI, AYTAÇ, EMRAH, Atmaca, Murat Mert, YAKA, ERDEM, ARSAVA, ETHEM MURAT, ALİOĞLU, ZEKERİYA, BOZDOĞAN, ZEHRA, YILMAZ, ZAHİDE, şener, ufuk, BAŞ, DEMET FUNDA, TOPLUTAŞ, EREN, DEĞİRMENCİ, EYLEM, aslan, yıldız, EŞKUT, neslihan, ÖZÜM ÜNSAL, YAPRAK, CAN, UFUK, KESKİN, ONUR, İNCE, FATMA BİRSEN, DEMİR, TÜLİN, PİRİ ÇINAR, BİLGE, ATASOY, TUĞRUL, Büyükşerbetçi, Gülseren, AYDIN, İSA, ÇETİNER, MUSTAFA, ŞEN, MUSTAFA, TURGUT, NİLDA, DUMAN, AHMET TAŞKIN, BEKDİK ŞİRİNOCAK, PINAR, ASİL, TALİP, BAŞTAN, BİRGÜL, ACAR, BİLGEHAN ATILGAN, KISABAY, AYŞİN, YILMAZ, AYŞE, EREN, ALPER, ARLIER, ZÜLFİKAR, YÜREKLİ, VEDAT ALİ, ÖZEL, TUĞBA, ÖZTÜRK, ŞEREFNUR, Akçakoyunlu, MERVE, EPÇELİDEN, TUNCAY, BAYDEMİR, RECEP, BİLGİÇ, ADNAN BURAK, İLGEZDİ, İREM, MİDİ, İPEK, KARADELİ, HASAN HÜSEYİN, KALE, NİLÜFER, BATUR ÇAĞLAYAN, HALE ZEYNEP, TOPÇUOĞLU, MEHMET AKİF, ÖZDEMİR, ATİLLA ÖZCAN, ÇOBAN, EDA, EKİZOĞLU, ESME, KIZEK, ÖZGÜ, GÜRKAŞ, ERDEM, AKYOL, ŞENOL, SORGUN, MİNE HAYRİYE, MİLANLIOĞLU, AYSEL, BİLGİLİ, ÖZLEM, ASLANBABA BAHADIR, EDA, TOGAY IŞIKAY, CANAN, KRESPİ, YAKUP, GÖKÇE, MUSTAFA, bavli, songül, çabalar, murat, YAYLA, VİLDAN AYŞE, erdoğan, hacı ali, ÖZKUL, AYÇA, güneş, aygül, DEĞİRMENCİ UZUN, BAHAR, ALUÇLU, MEHMET UFUK, KOZAK, HASAN HÜSEYİN, GÜNGÖR, İBRAHİM LEVENT, Erdoğan, Mücahid, özdemir acar, zeynep, CENİKLİ, UTKU, KABLAN, YÜKSEL, YILMAZ, İBRAHİM ARDA, GENÇ, HAMİD, NAZLIEL, BİJEN, SARIÖNDER GENCER, ELİF, AY, HALİL, YEVGİ, RECEP, KUNT, REFİK, DEMİRBAŞ, HAYRİ, AKDOĞAN, ÖZLEM, EMRE, UFUK, KAYIM YILDIZ, ÖZLEM, BOLAYIR, ASLI, DEMİR, TURGAY, Tanrıverdi, ZEYNEP, YALAZ TEKAN, ÜLGEN, GİRAY, SEMİH, YAZICI, SİNEM, ŞENADIM, SONGÜL, YOLDAŞ, TAHİR KURTULUŞ, AKPINAR, ÇETİN KÜRŞAD, ÖZKAN, ESRA, İLİK, FAİK, ŞİRİN, HADİYE, GÜLER, AYŞE, ÖNDER, HALİL, BEKTAŞ, HESNA, ÖCEK, LEVENT, BAKAR, HACI MUSTAFA, ONGUN, NEDİM, and KURŞUN, OĞUZHAN

Published
2020

26. TÜRKİYE’DE AKUT İNME YÖNETİMİ: IV TPA VE TROMBEKTOMİ NÖROTEK: TÜRKİYE NÖROLOJİ TEK GÜNÇALIŞMASI

Author

YOLDAŞ, TAHİR KURTULUŞ, KAYIM YILDIZ, ÖZLEM, BOLAYIR, ASLI, KISABAY, AYSIN, ÇOBAN, EDA, BAŞTAN, AYSIN, ACAR, ZEYNEP, NİFTİOĞLU, BUKET, GÜNGÖR, İBRAHİM LEVENT, GÜVEN, BÜLENT, KAYA, DİLAVER, AFŞAR FAK, NAZİRE EFSER YEŞİM, YAZICI, DURAN, AKYOL, ŞENOL, BİLGİÇ, ADNAN BURAK, İLGEZDİ, İREM, BEKTAŞ, HESNA, DEĞİRMENCİ, EYLEM, TOPLUTAŞ, eren, ÖZKAN, ESRA, İLİK, FAİK, İNCE, FATMA BİRSEN, BÜYÜKŞERBETÇI, GÜLSEREN, GÜRKAŞ, ERDEM, MİLANLIOĞLU, AYSEL, YILMAZ, AYŞE, GENÇ, HAMİDULLAH, YILMAZ, İBRAHİM ARDA, ALİOĞLU, ZEKERİYA, EŞKUT, NESLİHAN, ÖZÜM ÜNSAL, YAPRAK, ÖNDER, HALİL, KARADELİ, HASAN HÜSEYİN, KOZAK, HASAN HÜSEYİN, DEMİRBAŞ, HAYRİ, MİDİ, İPEK, AYDIN, İSA, EPÇELİDEN, M TUNCAY, YEŞİLOT, NİLÜFER, ATMACA, MURAT MERT, BAKAR, HACI MUSTAFA, ŞEN, MUSTAFA, TURGUT, NİLDA, KESKİN, ONUR, AKDOĞAN, ÖZLEM, EMRE, UFUK, BİLGİLİ, ÖZLEM, BEKDİK ŞİRİNOCAK, PINAR, YEVGİ, RECEP, AKKAŞ YAZICI, SİNEM, DUMAN, AHMET TAŞKIN, ÖZEL, TUĞBA, ÜNAL, ALİ, DORA, BABÜR, ATASOY, TURGUT, PİRİ ÇINAR, BİLGE, DEMİR, TÜLİN, DEMİR, TURGAY, CAN, UFUK, ASLAN, YILDIZ, BAŞ, DEMET FUNDA, YILMAZ, ZAHİDE, BOZDOĞAN, ZEHRA, ŞENADIM, SONGÜL, ÖZDEMİR, GÖKHAN, KRESPİ, YAKUP, ÖZTÜRK, ŞEREFNUR, KUNT, REFİK, AY, HALİL, AYTAÇ, EMRAH, SORGUN, MİNE HAYRİYE, ASLANBABA BAHADIR, EDA, TOGAY IŞIKAY, CANAN, ALUÇLU, MEHMET UFUK, DEĞİRMENCI, BAHAR, ÖZKUL, AYÇA, KIZEK, ÖZGÜ, KURŞUN, OĞUZHAN, YAKA, ERDEM, BAVLI, SONGÜL, GÖKÇE, MUSTAFA, CENİKLİ, UTKU, EREN, ALPER, ongun, nedim, NAZLIEL, BİJEN, ÇETİNER, MUSTAFA, ÖCEK, LEVENT, akçakoyunlu, merve, BAYDEMİR, RECEP, GÜLER, AYŞE, ŞİRİN, HADİYE, ACAR, BİLGEHAN ATILGAN, YÜREKLİ, VEDAT ALİ, AKPINAR, ÇETİN KÜRŞAD, asil, talip, yalaz tekan, ülgen, tanrıverdi, zeynep, BATUR ÇAĞLAYAN, HALE ZEYNEP, TOPÇUOĞLU, MEHMET AKİF, ÖZDEMİR, ATİLLA ÖZCAN, ARSAVA, ETHEM MURAT, güneş, aygül, AYKAÇ, ÖZLEM, SARIÖNDER GENCER, ELİF, çabalar, murat, YAYLA, VİLDAN AYŞE, erdoğan, hacı ali, erdoğan, mücahid, özdemir acar, zeynep, and KABLAN, YÜKSEL

Published
2020

27. TÜRKİYE’DE AKUT İNME YÖNETİMİ: IV TPA VE TROMBEKTOMİ NÖROTEK: TÜRKİYE NÖROLOJİ TEK GÜN ÇALIŞMASI

Author

BİLGİLİ, ÖZLEM, BEKDİK ŞİRİNOCAK, PINAR, YEVGİ, RECEP, AKKAŞ YAZICI, SİNEM, YOLDAŞ, TAHİR KURTULUŞ, DUMAN, AHMET TAŞKIN, ÖZEL, TUĞBA, ÜNAL, ALİ, DORA, BABÜR, ATASOY, TURGUT, PİRİ ÇİNAR, BİLGE, DEMİR, TÜLİN, DEMİR, TURGAY, ASLAN, YILDIZ, BAŞ SÖKMEZ, DEMET FUNDA, YILMAZ, ZAHİDE, BOZDOĞAN ŞENEL, ZEHRA, ÖZDEMİR, GÖKHAN, KRESPİ, YAKUP, ÖZTÜRK, ŞEREFNUR, CAN, UFUK, YAKA, ERDEM, TOPÇUOĞLU, MEHMET AKİF, ÖZDEMİR, ATİLLA ÖZCAN, ARSAVA, ETHEM MURAT, GÜNEŞ, AYGÜL, AYKAÇ, ÖZLEM, SARIÖNDER GENCER, ELİF, YAYLA, VİLDAN AYŞE, ERDOĞAN, HACI ALİ, ÖZDEMİR ACAR, ZEYNEP, KABLAN, YÜKSEL, TANRIVERDİ, ZEYNEP, YALAZ TEKAN, ÜLGEN, ASIL, TALİP, AKPINAR, ÇETİN KÜRŞAD, YÜREKLİ, VEDAT ALİ, ACAR, BİLGEHAN ATILGAN, ŞİRİN, HADİYE, GÜLER, AYŞE, BAYDEMİR, RECEP, AKCAKOYUNLU, MERVE, ÖCEK, LEVENT, ÇETİNER, MUSTAFA, NAZLIEL, BİJEN, BATUR ÇAĞLAYAN, HALE ZEYNEP, ONGUN, NEDİM, EREN, ALPER, CENİKLİ, UTKU, GÖKÇE, MUSTAFA, BAVLİ, SONGÜL, ÖZKUL, AYÇA, DEGİRMENCİ, BAHAR, ALUÇLU, MEHMET UFUK, TOGAY IŞIKAY, CANAN, ASLANBABA BAHADIR, EDA, SORGUN, MİNE HAYRİYE, AYTAÇ, EMRAH, AY, HALİL, KUNT, REFİK, ŞENADIM, SONGÜL, ÖZÜM ÜNSAL, YAPRAK, EŞKUT, NESLİHAN, ALİOĞLU, ZEKERİYA, YILMAZ, İBRAHİM ARDA, GENÇ, HAMİDULLAH, YILMAZ, AYŞE, MİLANLIOĞLU, AYSEL, GÜRKAŞ, ERDEM, DEĞİRMENCİ, EYLEM, BEKTAŞ, HESNA, İLGEZDİ, İREM, BİLGİÇ, ADNAN BURAK, AKYOL, ŞENOL, GÜNGÖR, İBRAHİM LEVENT, ÇOBAN, EDA, YEŞİLOT, NİLÜFER, KİZEK, ÖZGÜ, KURŞUN, OĞUZHAN, KAYIM YILDIZ, ÖZLEM, BOLAYIR, ASLI, KISABAY AK, AYŞIN, BAŞTAN, AYSIN, ACAR, ZEYNEP, NİFTİOĞLU, BUKET, GÜVEN, BÜLENT, KAYA, DİLAVER, AFŞAR FAK, NAZİRE EFSER YEŞİM, YAZICI, DURAN, TOPLUTAŞ, EREN, ÖZKAN, ESRA, İLİK, FAİK, İNCE, FATMA BİRSEN, BÜYÜKŞERBETCİ, GÜLSEREN, ÖNDER, HALİL, KARADELİ, HASAN HÜSEYİN, KOZAK, HASAN HÜSEYİN, DEMİRBAŞ, HAYRİ, MİDİ, İPEK, AYDIN, İSA, EPÇELİDEN, TUNCAY, ATMACA, MURAT MERT, BAKAR, HACI MUSTAFA, ŞEN, MUSTAFA, TURGUT, NİLDA, KESKİN, ONUR, AKDOĞAN, ÖZLEM, and EMRE, UFUK

Published
2020

31. Isolated abducens nerve palsy: Comparison of microvascular and other causes.

Author

Erdal, Yuksel, Gunes, Taskin, and Emre, Ufuk

Subjects
ABDUCENS nerve, NEUROPATHY, ETIOLOGY of diseases, DIABETES, BLOOD sugar
Abstract

OBJECTIVE: Abducens nerve paralysis is the most common ocular motor neuropathy. In this article, we aimed to compare the causes of isolated abducens nerve palsy in terms of demographic, clinical features, and prognosis. METHODS: Thirty-six isolated abducens nerve palsy patients were prospectively enrolled in the study. The demographic, clinical features, and prognosis compared in two etiological groups as microvascular and other causes. RESULTS: The most common etiology was microvascular, which was seen in 16/36 (44.4%) patients. Mean clinical recovery time was 2.5±1.3 months (range, 10 days–6 months). When etiological groups were compared as microvascular and other causes, the mean age of the microvascular group was significantly higher (62.8±13.3 vs. 44.5±16.4, p=0.001). Diabetes mellitus was seen significantly higher in the microvascular group than other causes group (p=0.001), but no significant difference was observed in terms of other atherosclerotic risk factors (p>0.05). The fasting blood glucose and hemoglobin A1c value were significantly higher in the microvascular group (p=0.02 and p=0.02, respectively). There was no significant difference in terms of clinical improvement and clinical recovery times between groups (p>0.05). CONCLUSION: There is no difference between microvascular group and other causes in terms of clinical outcome, while the mean age and presence of diabetes were higher in the microvascular group. The presence of diabetes should be questioned in cases with isolated abducens nerve palsy. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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41. Could Serum Endocan Be a Vascular Endothelial Marker in Relapsing-Remitting Multiple Sclerosis?

Author

Atalar, Arife Çimen, Köseoğlu, Mesrure, Yavuz, Nurettin, Erdal, Yüksel, Oğuz, Osman, and Emre, Ufuk

Subjects
MULTIPLE sclerosis, BIOMARKERS, C-reactive protein, STATISTICS, ENDOTHELIUM, INFLAMMATION, HEALTH outcome assessment, MANN Whitney U Test, COMPARATIVE studies, GLYCOPROTEINS, BLOOD sedimentation, ENZYME-linked immunosorbent assay, DESCRIPTIVE statistics, CHI-squared test, BLOOD cell count, RECEIVER operating characteristic curves, DATA analysis, DATA analysis software, LONGITUDINAL method, MEDICAL needs assessment
Abstract

Copyright of Turkish Journal of Neurology / Turk Noroloji Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
Full Text
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50. Restless Legs Syndrome in Multiple Sclerosis.

Author

GÜNEŞ, Taşkın, EMRE, Ufuk, ERDAL, Yüksel, and YALIN, Osman Özgür

Subjects
*MULTIPLE sclerosis, *DISEASE incidence, *PSYCHOLOGICAL tests, *SEVERITY of illness index, *RISK assessment, *DESCRIPTIVE statistics, *MENTAL depression, *INTESTINAL diseases, *ANXIETY, *FATIGUE (Physiology), *BLADDER diseases, *RESTLESS legs syndrome, *LONGITUDINAL method, *SYMPTOMS, *DISEASE complications
Abstract

Introduction: The co-existence of Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED/WED) and multiple sclerosis (MS) is a common condition. For this reason, we aimed to evaluate the effects of RLS/WED and its relationship with MS. Methods: We evaluated the clinical features of 102 patients diagnosed with MS who were in follow-up between 2010 and 2015 in outpatient clinic. All the patients were evaluated for RLS/WED according to the revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria. The Expanded Disability Status Scale (EDSS), Beck Depression Inventory, Beck Anxiety Inventory and Fatigue Severity Scale scores of all the patients were recorded. The IRLSSG 2003 severity scale was used to determine the degree of RLS/WED. Results: RLS/WED was detected in 30.4% (n=31) of the patients (MSRLS/WED+), but not in 69.6% (n=71) (MS-RLS/WED-). The mean EDSS score of the MS-RLS/WED+ patients were 3.2±2.1 while the MS-RLS/WED-patients were 2.0±1.6. The incidences of depression, moderate or severe anxiety, fatigue and intestinal and bladder dysfunction in the MS-RLS/WED+ patients were significantly higher. Regarding to RLS/WED complaints, 32.2% were mild, 35.4% were moderate, 19.3% were severe and 12.9% were very severe. When the MS subgroups were evaluated the highest RLS/WED severity score was found in the secondary progressive MS group. In the patients with pyramidal symptoms and intestinal and bladder dysfunction, the mean RLS/WED severity was significantly higher. The mean RLS/WED severity score was also significantly higher in those with depression and anxiety. The RLS/WED severity was significantly correlated with the number of pyramidal attacks and the EDSS score. Conclusion: Restless legs syndrome is a cause of depression, anxiety and fatigue and has negative effects on MS patients. Therefore, after the diagnosis of MS, the RLS/WED symptoms and signs should be determined, as soon as possible, in addition to the other MS symptoms. The treatment of this condition should be started early. [ABSTRACT FROM AUTHOR]

Published
2021
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