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Antecedentes: En Cuba, los linfomas se han incluído tradicionalmente entre Ias localizaciones de câncer más frecuentes. Objetivos: Se describió el comportamiento de la incidência y la mortalidad de los linfomas entre 1976 y 1990, de acuerdo a Ias principales variables epidemiológicas; edad, sexo y variedad histológica. Método: Se incluyeron todos los casos reportados al Registro Nacional de Câncer entre 1976 y 1990. Los casos fueron agrupados en Ias dos categorias diagnosticas clásicas: Enfermedad de Hodgkin y Linfomas no Hodgkinianos y de acuerdo al momento de reporte, en tres períodos quinquenales. Eueron calculadas Ias tasas específicas para los grupos de edad y Ias tasas estandarizadas a la población mundial. Resultados: Una marcada masculinidad fue encontrada en ambas categorias diagnosticas tanto en la incidência como en la mortalidad. La incidência tanto en la Enfermedad de Hodgkin como en los Linfomas no Hodgkinianos ha tenido un comportamiento ascendente en el tiempo. Um aumento de la tendencia, tanto de la incidência como de la mortalidad, se observa para el grupo de edad de 65 anos y más, mientras que la disminución de la mortalidad está clara para el grupo de 0 - 14 anos.

El estudio de la enfermedad de Hodgkin, tiene algunos siglos. Durante todo este tiempo, se han hecho adelantos notables en la patología, epidemiología, diagnóstico y tratamiento de esta poca común enfermedad. A pesar de todo esto todavía existen controversias con respecto a esta enfermedad. Este artículo revisa aquellos aspectos importantes de la literatura. Especial énfasis se da a los estudios de inmunopatología, de extensión incluyendo la tomografía computarizada, gammagrafía con galio, linfangiografía y laparotomía. Opciones de tratamiento, incluyendo radioterapia, quimioterapia, otras modalidades de tratamiento, y aquellas complicaciones más frecuentes encontradas en los pacientes.

Introducción: El Linfoma de Hodgkin (LH), es una neoplasia hematológica poco frecuente, donde las células neoplásicas forman una minoría del tumor y están rodeados por un medio inflamatorio reactivo que incluye linfocitos, eosinófilos, neutrófilos, histiocitos y células plasmáticas. El objetivo del presente estudio fue describir una población con esta patología y su supervivencia en 7 años de seguimiento. Metodología: Este estudio longitudinal, se realizó en el Hospital Carlos Andrade Marín, de Quito, Ecuador, del período 2013- 2019, con una muestra no probabilística, de pacientes con LH. Se registraron variables demográficas, clínicas, de laboratorio, clasificación Ann Arbor, clasificación histológica, tratamiento y respuesta, mortalidad y tiempo de supervivencia. Se utiliza estadística descriptiva; bivariada y un análisis de supervivencia. Resultados: Se analizan 73 casos, 43 hombres (58.9 %). El grupo etáreo más prevalente fue el de 61 a 70 años con 19 casos (26 %). 1 caso (4.1 %) con VIH. El 9.6% (7 casos) recibían tratamiento con inmunosupresores. Síntomas B en 49 casos (67.1%). Adenomegalias en 15 casos (20.5 %). Masa Bulky 5 casos (6.8 %). Fallecieron 22 casos (30.1 %). Supervivencia media de 52.8 meses, el 83.6% de los pacientes recibieron Adriamicina, Bleomicina, Vincristina y Doxorrubicina como 1ra línea de tratamiento, con remisión completa en el 61.7%. El estadio IV de Ann Arbor incremento significativamente la mortalidad (HR: 3.474, IC95%: 1.202 – 6.112, P= 0.036). Pacientes con la variante de depleción linfocitaria tuvieron mayor probabilidad de fallecimiento (HR: 4.975, IC95%: 1.313 – 9.472, P= 0.041). Los valores medios de hemoglobina < 10.5 g/dL (HR: 2.395, IC95%: 1.466 – 5.941, P= 0.029), albúmina < 4 g/dL (HR: 4.020, IC95%: 1.936 – 7.257, P= 0.011) y linfocitos < 600 células/µL (HR: 4.572, IC95%: 1.853 – 11.282, P= 0.001). Conclusión: La prevalencia de LH fue ligeramente mayor en hombres que en mujeres, con una relación de 1.1: 1. La incidencia por edad tuvo dos picos, entre 31-40 años y entre 61-70 años. La diabetes e hipertensión fueron las mayores comorbilidades previas al diagnóstico. La sintomatología más frecuente fueron los síntomas B, la segunda manifestación clínica más frecuente fue adenomegalias. Los estadios II y III (Ann Arbor) fueron los más frecuentes. El promedio de Hemoglobina fue menor en los fallecidos, así como la albúmina. Para el tratamiento de primera línea se utilizó ABVD, con lo cual se alcanzó remisión completa en el 61.7% de los casos. La ausencia de síntomas B, se relacionó con una mayor supervivencia; los estadios avanzados se relacionaron con peor supervivencia; la supervivencia fue mayor en pacientes que obtuvieron remisión completa con la primera línea de tratamiento; la supervivencia no se vio afectada por el uso de radioterapia y la supervivencia general fue menor a la encontrada en países desarrollados.

Hodgkin's disease is a lymphoproliferative disease, which is part of a subgroup of hematological diseases that also includes multiple myeloma, non-Hodgkin's disease and lymphocytic leukemias; it represents 1% of all malignancies in industrialized countries and 10% of all lymphomas. A review of the main nodal and extranodal radiological findings in Hodgkin's disease was carried out. The bibliographic search was done in PudMed, Medline, Science Direct, Lilacs and Embase from January 2018 to April 2018, using the terms MeSH: lymphoma, Hodgkin disease, radiology. The adequate recognition of radiological findings in each of the organs and systems makes imaging studies the cornerstone of the identification of nodal and extranodal involvement in Hodgkin's disease. [ABSTRACT FROM AUTHOR]

Background: The synchronous association of Hodgkin lymphoma and non-Hodgkin lymphoma in the same patient is very rare. Case report: A 68 years old male patient who began his disease with cervical and axillary adenomegaly, it was performed an excisional biopsy and a mixed cell-type Hodgkin lymphoma was found. Chemotherapy with partial response was initiated. During the course of the treatment, refractory lesions were observed in skin and muscle. Radiation oncology service decided to make a second biopsy which confirms the presence of a large diffuse B cell non-Hodgkin lymphoma. Conclusions: This case is an example of how when you have a patient with a typical clinical picture of bad prognosis, the diagnosis should be reconsidered and laboratory studies previously done must be repeated to rule out alternative diagnoses that may change the course of the disease. [ABSTRACT FROM AUTHOR]

Se realiza un revisión de 63 pacientes con enfermedad de Hodgkin en los últimos 7 años. El 75% de los pacientes eran varones. La mayoría de ellos entre 6-10 años de edad, representando el 51% de los pacientes. La presentación clínica más común fueron las adenopatías cervicales (47%). La esclerosis nodular y la celularidad mixta fueron las formas histológicas más comunes. El 60% en estadios avanzados. 11 pacientes abandonaron la terapia, 8 recayeron de la enfermedad y 2 fallecieron. La sobrevida global fue el 81% y la sobrevida libre de recaída fue del 76%.

Copyright of Arquivos de Neuro-Psiquiatria is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Paulista de Enfermagem is the property of Universidade Federal de Sao Paulo, Escola Paulista de Enfermagem and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Paulista de Enfermagem is the property of Universidade Federal de Sao Paulo, Escola Paulista de Enfermagem and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Se realizó un estudio descriptivo, transversal y retrospectivo de 131 pacientes con linfomas malignos en Santiago de Cuba durante el quinquenio 2001- 2005, con vista a valorar su frecuencia de aparición en habitantes de esta provincia. Entre las variables analizadas figuraron: edad, sexo, variedad histológica, estadio clínico, esquemas terapéuticos y respuesta clínica. Los linfomas no Hodgkin, que resultaron ser los más comunes, prevalecieron en los mayores de 50 años y en el sexo masculino, mientras la enfermedad de Hodgkin predominó en personas jóvenes y en las féminas, con primacía de estadios avanzados en ambas modalidades. La poliquimioterapia más empleada fue CHOP-Bleo en el primer grupo y MOPP/AVB en el segundo, con remisión completa de la afección en 40,5 y 19,1 %, respectivamente.A cross sectional, descriptive and retrospective study was carried out in 131 patients with malignant lymphomas in Santiago de Cuba during the five years period 2001-2005 in order to evaluate its frequency in people of this province. Among the analyzed variables were age, sex, histological variety, clinical stage, therapeutic regimens and clinical response. Non-Hodgkin lymphomas, which were the most common, prevailed in those patients over 50 years and in males, while the Hodgkin's disease prevailed in young people and in females, with predominance of advanced stages in both conditions. The most commonly used polychemotherapy was CHOP-Bleo in the first group and MOPP/AVB in the second one, with complete remission of the disease in 40,5 and 19,1% of patients, respectively.

Comunicamos un caso de mucormicosis intestinal en un hombre de 46 años de edad, diagnosticado de enfermedad de Hodgkin clásica, estadio IV-B. Durante la primera fase de la quimioterapia, sufrió una hemorragia digestiva masiva secundaria a una úlcera yeyunal por zigomicosis tipo mucor, diagnosticada por biopsia endoscópica. El paciente fue tratado con antifúngicos y resección quirúrgica del intestino afectado. En la cirugía, se apreció una doble perforación yeyunal cubierta. El estudio anatomopatológico de la pieza confirmó el diagnóstico previo. Tras un año de seguimiento, el paciente está recuperado y su linfoma de Hodgkin en remisión completa. Tras una extensa revisión de la literatura, según nuestro conocimiento, este es el segundo caso publicado en la literatura de mucormicosis intestinal en un paciente con linfoma de Hodgkin.We report a case of intestinal mucormycosis in a 46-year-old male diagnosed with classical Hodgkin's disease, IV-B stage. During the first phase of chemotherapy he had a massive digestive bleeding event secondary to a jejunal ulcer, and zygomicosis mucor-type was diagnosed by endoscopic biopsy. The patient was treated with antifungal drugs and surgical resection of the intestine involved. At surgery a double covered perforation of the jejunum was seen. Pathological examination confirmed the previous diagnosis. After one year of follow-up the patient is doing well, and his lymphoma is on remission. To our best knowledge this is the second case of intestinal mucormycosis in a patient with Hodgkin's lymphoma reported in the medical literature.

Chylothorax, is the accumulation of lymph in the pleural space, whose causes complication of Hodgkin's disease, lymphatic obstruction to generate conduit through multiple masses; worsen pre-existing tables; as gestation. The clinical case of a pregnant 24 year old debuted with pleural effusion chylothorax secondary characteristics even Hodgkin's disease occurs; which was treated by monitoring and proper diet as well as pleural drainage at first and then only with strict monitoring and low-fat diet, without presenting a satisfactory clinical outcome after relapse. Different approaches to this complication, as well as the treatment of pregnancy in the context of Hodgkin's disease is discussed. Also, conservative management of this complication and timely completion of pregnancy is highlighted by the most appropriate route. [ABSTRACT FROM AUTHOR]

Se realizó un estudio descriptivo en 88 pacientes con linfomas (25 con enfermedad de Hodgkin y 63 con linfoma no Hodgkin) atendidos en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras" desde abril de 1997 hasta diciembre de 1998, para identificar las manifestaciones pulmonares. Se estudiaron los síntomas y signos del aparato respiratorio y los resultados de la radiografía del tórax en todos los pacientes. En 79 de ellos se realizaron pruebas funcionales respiratorias. Predominaron los pacientes asintomáticos (69/88; 78,4 %) (p < 0,01), el síntoma respiratorio más frecuente fue la tos (6/25; 24 % en la enfermedad de Hodgkin y 10/63; 15,8 % en los linfomas no Hodgkin). Una proporción elevada de pacientes no tuvieron alteraciones al realizar examen físico respiratorio (73/88; 82,9 %) (p < 0,01), la disminución del murmullo vesicular fue la alteración más frecuente (15/88; 17 %). Se constató radiología del tórax normal en más de la mitad de los casos (53/88; 60,2 %) (p=0,025) y las adenopatías mediastinales fueron las alteraciones de mayor frecuencia (30/88; 34 %). Las alteraciones radiográficas fueron más frecuentes en la enfermedad de Hodgkin (18/25; 72 %) que en los linfomas no Hodgkin (17/63, 27 %). En las pruebas funcionales respiratorias, el 74,7 % fue normal (59/79; p < 0,01) mientras que el trastorno ventilatorio restrictivo ligero tuvo mayor presentación (9/79, 11,4 %). Los datos obtenidos evidencian que en el grupo de enfermos estudiados la frecuencia de las manifestaciones pulmonares es similar a la reportada por otros autores y que no existen síntomas ni signos respiratorios patognomónicos para cada tipo de linfoma.A descriptive study was conducted in 88 patients with lymphomas (25 Hodgkin’s disease and 63 non-Hodgkin’s lymphoma) seen at "Hermanos Ameijeiras" Clinical and Surgical Hospital from April 1997 to December 1998. Its objective was to identify the pulmonary manifestations. Symptoms and signs of the respiratory system and chest Rx results were analyzed in all the patients. Seventy-nine of them underwent respiratory function testing. Asymptomatic patients prevailed (69/88 for 78,4 %) (p < 0,01); the most frequent respiratory symptom was cough (6/25 for 24 % in Hodgkin’s disease and 10/63 for 15,8 % in non-Hodgkin’s lymphomas). A high number of patients did not present alterations when they were applied a respiratory physical exam (73/88 for 82,9 %) (p < 0,01); the reduction of vesicular breath sounds was the most frequent disturbance (15/88 for 17 %). It was observed that chest radiology was normal in more than half of the cases (53/88 for 60.2%) (p = 0,025) and mediastinal adenopathies were the most frequent disorders (30/88 for 34 %). Alterations in X-rays were mostly found in Hodgkin’s disease (18/25 for 72 %) that non-Hodgkin´s lymphoma (17/63, 27 %). The respiratory function tests were normal in 74.7 % of the cases (59/79) (p < 0,01) whereas slight restrictive ventilatory disorder was more detected (9/79 for 11,4 %). Data revealed that in the group of studied patients, the frequency of pulmonary manifestations is similar to the one reported by other authors and that there are neither pathognomonic respiratory symptoms nor signs for each type of lymphoma.

Se realizó un estudio descriptivo prospectivo en 270 pacientes con diagnóstico de linfoma ingresados en el Servicio de Hematología del Hospital Clinicoquirúrgico "Hermanos Ameijeiras" de Ciudad de La Habana, Cuba, en el período comprendido del 1ro de marzo de 1996 al 31 de diciembre de 1998, para conocer las complicaciones neurológicas. Se detectaron 26 pacientes con complicaciones neurológicas. De 188 enfermos con linfomas no-Hodgkin, el 12,2 % presentó manifestaciones neurológicas. En estos pacientes, la infiltración leptomeníngea fue la complicación neurológica más frecuente. En los 82 pacientes con enfermedad de Hodgkin, solamente 3,6 % tuvieron alteraciones neurológicas y la infección por Herpes zoster fue la más común. Se observó el mayor porcentaje de pacientes con síntomas y signos atribuibles a compresión de la médula espinal y a la alteración de pares craneales, la cefalea como el síntoma más común y el déficit motor, el signo más frecuente. Se comprobó que los pacientes con linfoma no Hodgkin de alto grado de malignidad presentaron el mayor porcentaje de complicaciones neurológicas (28,7 %) y el tiempo promedio entre el diagnóstico del linfoma y el diagnóstico de la complicación neurológica fue menor en estos enfermos (5,5 meses). El tiempo de supervivencia después del diagnóstico de las manifestaciones neurológicas en la mayoría de los pacientes fue inferior a un año. De los 14 pacientes fallecidos, la complicación neurológica fue la principal causa directa de la muerteA prospective and descriptive study was carried out in 270 patients diagnosed of lymphoma, admitted in Hematology Service of "Hermanos Ameijeiras" Clinical Surgical Hospital in Havana City, Cuba, from March 1, 1996 to December 31, 1998, to assess neurologic complications. 26 patients presenting with neurologic complications were detected. From 188 sick persons with non-Hodgkin's lymphoma, 12,2 % had neurologic manifestations. In these patients, leptomeninges infiltration was the more frequent neurologic complication. In 82 patients with Hodgkin's disease, only 3,6 % had neurologic alteration and Herpes zoster infection was the commonest one. We found higher percent of patients with syndromes attributable to spinal cord compression and to craneal pars disturbance, headache was commonest and motor deficit the more frequent one. It was confirmed that patients carriers of high grade malinancy non-Hodgkin' s lymphoma, had the great percentage of neurologic complications (28,7 %), and average time between diagnosis of lymphoma and that of neurologic complications was shorter in these patients was (5,5 months). Survival after diagnosis of neurologic manifestations in most patients was under l year. In 14 patients deceaced, neurologic complication was main direct cause of death

La enfermedad de Hodgkin, considerada una neoplasia linfoide, se clasifica en 5 grupos a partir de la conferencia de Rye en 1966. La variedad esclerosis nodular es la más frecuente, afecta generalmente regiones supradiafragmáticas y se divide en 2 grados, con características morfológicas y pronósticas diferentes. El grado II, de mal pronóstico, exige formas de tratamiento más agresivas. La celularidad mixta suele tener mayor diseminación de la enfermedad y junto a la esclerosis nodular, se catalogan como formas clásicas de la enfermedad, con positividad para los marcadores inmunofenotípicos CD15 y CD30. El predominio linfocítico se considera un linfoma de células del centro germinal y emerge como entidad clínicopatológica diferente. La depleción linfocítica se diagnostica con baja frecuencia y tiene un pronóstico desfavorable. El diagnóstico diferencial con linfomas no hodgkinianos no siempre es posible y actualmente se señala que la delimitación entre ambos tipos de linfomas no está bien definida. El grupo no clasificado tiende a desaparecerHodgkin´s disease, considered a lymphoid neoplasia, is classified in 5 groups, since Rye Conference in 1960. Nodular sclerosis variety is commonest, generally involve supradiaphragmatic regions and is divided in two grades with distinct morphologic ant prognostic features. Grade II of badly prognosis demand a more aggresive treatment. Mixed cellularity ussualy has a greater disease spreading level and joined with nodular sclerosis, are classified as classic forms of disease, positive to immunophenotypical markers, CD15 and CD30. Lymphocytic predominance is to be considered as a cell lymphoma of germinal center and emerge as a distinct clinico-pathologic entity with a unfavourable prognosis. Differential diagnosis in non-Hodgkin´s lymphomas, unusually is possible and at present, delimitation between both types of lymphoma, es not well defined. Non classified group have a tendency to disappear

Copyright of Revista Española de Patología is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Se revisaron las alteraciones histopatológicas del hígado en las necropsias de 71 pacientes con linfomas malignos, 24 con enfermedad de Hodgkin (EH) y 47 con linfomas no Hodgkin (LNH). Se constató la infiltración linfomatosa en 6 pacientes (8 %) en la biopsia hepática inicial y en 44 (62 %) en las necropsias y este último hallazgo fue mayor en la EH (16/24,67 %) que en los LNH (28/47,60 %). Se encontraron sólo 8 fallecidos (11 %) que no tenían ninguna alteración y 19 (27 %) presentaron alteraciones histológicas no infiltrativas, aisladas o combinadas. Se observaron la fibrosis y la necrosis con una frecuencia significativamente mayor en la EH (16/24,67 % p = 0,0000 y 13/24,54 %, p = 0,0208) y se sugirió la posibilidad de que la enfermedad tenga un papel patogénico en las mismas. Se comprobó que la congestión y la esteatosis tuvieron mayor incidencia en los LNH (28/47,60 % y 24/47,49 %) y que la congestión fue la alteración inespecífica más frecuente en todos los pacientes (53,5 %) seguida de la necrosis (45 %). No hubo correlación entre los hallazgos histológicos de las necropsias con el estado de la enfermedad, presencia de visceromegalia, infiltración hepática inicial y terapéutica y tampoco se evidenció interacción entre diagnóstico y extensión de la enfermedad con respecto a las alteraciones histológicas. Se confirmó el incremento de la infiltración hepática con la progresión de la enfermedad en los pacientes con linfomas malignos y que 85 % de estos casos tiene algún tipo de alteración histopatológica en el hígado, infiltrativas y no infiltrativas, al momento del fallecimiento.Liver histopathological alterations were examined in 71 autopsies of patients with malignant lymphomas of whom 24 had Hodgkin´s disease (HD) and 47 non Hodgkin´s lymphomas. Lymphomatous infiltration was observed in 6 patients by initial liver biopsy (8 %) and in 44 patients by autopsies (62 %). This condition was higher in HD with 16 out of 24 patients (67 %) than in NHL with 28 out of 47 patients (60 %). Only 8 deceased (11 %) did not present any kind of alterations whereas 19 (27 %) had non-infiltrating histological alterations either isolated or combined. Frequency of fibrosis and necrosis was observed to be significantly higher in HD with 16 out of 24 patients (67 %, p = 0.0000) and 13 out of 24 patients (54 %), p = 0.0208) respectively, thus it was suggested that this disease is likely to have a pathogenic role in both processes. It was proved that congestion and steatosis had higher incidence on NHL with 28 out of 47 patients (60 %) and 24 out of 47 patients (49 %) respectively and that congestion was the most frequent non-specific alteration in all patients (53.5 % followed by necrosis (45 %). Neither correlation between histological findings from autopsies and disease status, visceromegaly, initial and therapeutical hepatic infiltration nor interaction between disease lenght and diagnosis, and histological alterations were found. It was confirmed that the increase of hepatic infiltration was linked to the course of the disease in patients with malignat lymphomas and that 85 % of these cases had some type of histopathological alteration either infiltrating or non-infiltrating in the liver at the time of their death.

The elassie Hodgkin's Lymphoma is more common in men than in women. The distribution in both sexes is bimodal with a peak of young adults ages 15-35 and another in older individuáis (55 year olds). The predominant histological subtype in young patients is nodular sclerosis and in patients 55 or older is mixed cellularity. The five-year survival rate for stages I II, III and IV is respectively of a 90, 84 and 65%. Mortality by classic Hodgkin's Lymphoma has decreased significantly thanks to the new treatment schemes and today represents only a 0.5 % of the causes of death in Mexico. Objective: Determine the loss of expression of CD 15 in patients with classic Hodgkin's Lymphoma. Material and methods: A cross-sectional, retrospective and descriptive study of patients with classic Hodgkin's Lymphoma, between 2001 and 2013 (April), was conducted, taken from a database of 261 patients, from file of biopsies from Hospital General de Mexico The histological incisions were examined and immunohistochemistry was carried out. Results: 156 cases were selected, it was noted that males (51.6%) are slightly more affected than women (48.4%), the most common type was the nodular sclerosis (59.5%); by age group it was observed that patients over 36 years of age the histologic type was the mixed cellular- ity (52%), all the cases that presented immunoreaction for CD15, some were in paranuclear region, cytoplasm or both, with intensity from 2 to 3 (+). The presence of the Epstein-Barr virus was observed in 59.6%. Conclusion: In this series of cases absence of expression of CD15 was observed in a 14.2% of the patients with classic Hodgkin's Lymphoma and no change was observed statistically significant when compared with the histological subtype. [ABSTRACT FROM AUTHOR]

Introduction: The inherent complexity of diseases demands a multidisciplinary attention to assure better results for patients. Intraspinal neoplasms are an example of this affirmation and however they don't have the highest frequency, the clinical and radiological characteristics could become in a challenge for medical staff. Objective: to present a patient with an uncommon lumbar intraspinal neoplasm. Clinical case: A 31 year old white male patient with an onset of back and sciatic pain and left leg paresthesias and signs of radicular entrapment of the fourth and fifth lumbar roots. Lumbar spine radiological study by computerized tomography and magnetic resonance imaging showed the presence of a neoplasm who invaded the spinal canal and infiltrated the third lumbar vertebral body. Surgical treatment was decided by a staff of orthopedics and neurosurgeons. A laminectomy of the second to forth lumbar vertebrae was made, total complete removal of the neoplastic lesion, curettage of the affected vertebral body, followed by vertebral fusion with spinous apophysis and Luque technique. The trans-operatory pathological diagnosis was Hodgkin lymphoma. The post-operatory follow up included hematology management with specific chemotherapy. The patient has a favorable evolution with two years of asymptomatic survival and without handicap. Conclusions: The precocious diagnosis of spine neoplasm toward an opportune and suitable treatment by a multidisciplinary team, assures the best results with a favorable repercussion in patients prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Salud Pública is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Linfoma não-Hodgkin sistêmico pode afetar o miocárdio, particularmente em pacientes imunocomprometidos. Quando presentes, sinais e sintomas são geralmente inespecíficos, tornando o diagnóstico de envolvimento cardíaco muito difícil antes da autópsia. Arritmias ventriculares também são pouco usuais nesse cenário. Descrevemos um caso de linfoma não-Hodgkin miocárdico secundário, que se apresentou com taquicardia ventricular monomórfica sustentada e espessamento do septo interventricular basal. Completa remissão das lesões miocárdicas foi observada após o término da quimioterapia de segunda linha, sem recorrências posteriores de arritmias em oito meses.

Considering the discovery of Hodgkin's disease, historical data indicates that Richard Paltauf (Vienna) in 1897 found several ganglionic syndromes named pseudoleukemias and could distinguish them from the malignant lymphogranuloma. Thereafter, in 1898 his pupil Charles Sternberg performed a detailed description of the ganglionic lesions, including the giant cells, today recognized as Sternberg cells. Many years before to the aforementioned facts, in 1832, Thomas Hodgkin (England) communicated to the Medical Society of London the existence of a kind of illness starting with the simultaneous growing of lymphatic ganglia and the spleen, evolving with fever and emaciation with final outcome to death. According to some authors, Hodgkin recognition as first discoverer is due to the honesty and kindness of doctor Wilks who in 1865 published a piece of work entitled " Clinical cases of growing of the lymphatic ganglia and spleen or Hodgkin's disease ", in which he added to the original description, the lesions he observed in liver, kidneys and lungs. Later, in 1902, Dorothy Reed accomplished the histopathology of Hodgkin's disease, describing its microscopic details. Giant cells were named Reed-Sternberg cells to recognize the researchers devoted to its study; these cells never were named cells of Greenfield, the investigator who actually first described them. Current treatment of this kind of neoplasms includes radiotherapy and polychemotherapeutic programs that so far have much improved the survival rate of these patients. [ABSTRACT FROM AUTHOR]

Objective. To evaluate the Hodgkin's disease treatment in children of two hospitals. Patients and methods. Twenty eight clinical files of Hodgkin's disease patients were analyzed, according to the stage on the disease, 24 patients received chemotherapy. The strategy was: Cyclophosphamide, vincristine, prednisone (COP), adriamycine, bleomicine, vinblastine, dacarbazine (ABVD). Results. Age averaged was 7.7 years age 12 were in III and IV stages, and the percentage of surviving outcome at 52 months was 92% in the chemotherapy group. Four patients in the «B» stage beside chemotherapy received radiotherapy with a similar overcome (90%). Conclusion. The chemotherapy without radiotherapy by itself could be an option for the future management of these children. [ABSTRACT FROM AUTHOR]

Introduction: Cervical lymphadenopathy in children is the clinical expression of a variety of diseases is sometimes difficult to differentiate and can be confused with other neck injuries less common. If the disturbance node over an inch is not resolved in the course of 6-8 weeks of conservative management must follow tomársele excisional biopsy to determine etiology of the lesion. It is for the Pediatric Surgeon obtain biopsy or lymph nodes from the neck representative histopathology in the diagnosis and give the child full treatment course. Material and Methods: We conducted a retrospective review, observational and descriptive cross a series of cases of cervical lymph node biopsy in the neck representative of children referred to pediatric surgery service for family practitioners, pediatricians and pediatric hematologists in our area of influence the period June 1998 to February 2006 to analyze measures of central tendency with age, sex, cervical topography, type of injury and monitoring of children based on the final pathological report. Results: We obtained biopsies of lymph nodes involved to provide the best material to the pathologist in the fresh impressions and review and final determination for the diagnosis, but suspects the diagnosis of malignancy was confirmed by immunohistochemical study of 61 patients obtained so of them were 42 males and 19 women. The age range was from eight months to 15 years with a median of seven years and an average of 7.72 years. By age groups had two infant children, 21 preschool children, 19 schools and 19 adolescents. Lymphadenopathy showed a topography in anterior midline in four children in a child later, nine submaxillary, a supraclavicular, three bilateral, 22 right and 21 left. The histopathological results we had 37 with reactive follicular hyperplasia, five with Hodgkin's disease, four with non-Hodgkin lymphoma, two of Castleman's disease, one of Disease Rosai Dorf- man a Angioino-munoblástica lymphadenopathy, a histiocytoid Hemangioendothelioma, a benign schwannoma, a salivary gland pleomorphic adenoma, a remnant of thymic cysts in thymic neck , five granulomatous lymphadenitis and two Cryptococcus lymphadenitis. The 37 patients were monitored reactive follicular hyperplasia in the medical unit of assignment, it was considered cured at the seven patients who received medical management for cryptococcosis and granulomatous lymphadenitis, which responded satisfactorily disappeared neck injuries, as well as those who were resected thymic remnants in the neck and salivary gland pleomorphic adenoma and finally the remaining 15 patients with malignant and invasive biological behavior are handled in pediatric hematology unit so far. Discussion: More than half of the biopsied patients had nonspecific reactive follicular hyperplasia remain consistent with those reported in the literature. Immunohistochemical techniques allowed to diagnostic accuracy in suspected cases of malignancy, therefore it is necessary to have a high index of suspicion. [ABSTRACT FROM AUTHOR]

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Hodgkin's disease is an entity with characteristic epidemiology. There is variation in its incidence, age, sex distribution, and morphology of Hodgkin's disease in different populations, according to geographic location, socioeconomic and immunologic status. Hodgkin's disease occurrence has been reported in US statistics and there is limited international data, suggesting either genetic or socioeconomic determinants of susceptibility. The anatomic extent of disease and the histological subtype are the primary factors determining the prognosis and optimal therapy. Objective: To assess the histological variants and clinical states at diagnosis in Hodgkins disease in three medical centers in Mexico. Material and methods: In this study, a total of 125 cases of Hodgkin's disease were diagnosed at three medical centers in which histopathic diagnosis and clinical stages were recorded. Results: Ages ranged from 4 to 87 years, (median: 29). A male predominance was found. Nodular sclerosing was the most frequent histological variant (53.6%) whereas lymphocyte predominance was the least common type (8%). Most of the cases were found in stage II (44.8%), and this, together with stage III, formed 76.8% of all Hodgkin's diseases. Patterns of geographic variation differed among the histological subtypes between two centers, with no significant variation for clinical stage. Conclusions: This study shows many similarities in proportion of lymphomas, and age and sex distribution of cases, to patterns observed in more economically developed countries. These findings are discussed with a view to further investigation due the limitations of small population studied. [ABSTRACT FROM AUTHOR]

En el contexto de los estudios epidemiológicos el uso del modelo de regresión logística se ha hecho cada vez más común. Esto implica la estimación de los parámetros y su relación con la estimación de la razón odds, como medida indirecta del riesgo relativo. El modelo de regresión logística se aplicó a un estudio de casos y controles de la enfermedad de Hodgkin, con datos del Instituto Nacional de Cancerología de Santafé de Bogotá, con el propósito de probar hipótesis vigentes acerca de la etiología infecciosa de la enfermedad.

La afectación del sistema nervioso central en la enfermedad de Hodgkin (HDG) es excepcional. Los pacientes con lesiones malignas tienen mayor riesgo de infarto cerebral. Se presentó un paciente con antecedente de enfermedad de HDG quien presentó episodios súbitos de deterioro del nivel de conciencia y que en el período de recuperación mostró severas alteraciones en sus funciones psíquicas superiores con trastornos groseros de la memoria de fijación y evocación, desorientación témporo-espacial, acalculia, perseveraciones, conducta inadecuada y agresividad. Se determinó, mediante estudios imagenológicos, tomografía axial computarizada y resonancia magnética nuclear, el diagnóstico de infarto talámico bilateral. Se concluyó que las lesiones del tálamo que se acompañan de alteraciones de las funciones psíquicas superiores de carácter demencial son comúnmente bilaterales y que es importante diagnosticar estas complicaciones porque la mayoría son tratables. Se recomendó realizar estudios neuropsicológicos periódicos para precisar si existe recuperación evolutiva de los trastornos cognitivos y conductuales o concluir su diagnóstico como una demencia vascular talámica.The affection of the central nervous system in Hodgkin's disease is exceptional. Patients with malignant lesions are at a higher risk for stroke. A patient with history of Hodgkin's disease that had sudden episodes of deterioration of the conciousness level and that in the recovery period presented severe alterations in his higher psychical functions with gross disorders of the fixation and evocation memory, temporospacial disorientation, acalculia, perseverations, inadequate behavior and aggressiveness, was presented. The diagnosis of bilateral thalamic infarction was determined by imaging studies, computerized axial tomography and nuclear magnetic imaging. It was concluded that the thalamus lesions accompanied with alterations of the higher psychical functions of demential character are usually bilateral and that it is important to diagnose these complications, since most of them may be treated. It was recommended to undertake periodical neuropsychological studies to know if there is an evolutive recuperation of the cognitive and behavorial disorders, or to finally diagnose a vascular thalamic dementia.

Se determinaron las concentraciones de IgG, IgA e IgM en el suero de 24 pacientes adultos con enfermedad de Hodgkin. Se detectó una disminución significativa (p < 0,001) de las 3 inmunoglobulinas en el grupo total de pacientes al compararlas con los controles normales. Se demostró una disminución de las inmunoglobulinas estudiadas en todos los enfermos en los estadios clínicos más avanzados, IIIB y IVB; la IgG e IgM se mantuvieron dentro de límites normales en el estadio IIA, no así la IgA que estaba disminuida. Los datos obtenidos en nuestro trabajo sugieren una posible asociación entre los niveles de IgG e IgM con la extensión de la enfermedadThe concentrations of IgG, IgA and IgM were determined in the serum of 24 adult patients with Hodgkin disease. It was detected a significant decrease (p