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2 results on '"ENHANCED ANTIBACTERIAL"'

1. Antibacterial Nanomaterials:Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Author

Xie, Maomao, Gao, Meng, Yun, Yang, Malmsten, Martin, Rotello, Vincent M. M., Zboril, Radek, Akhavan, Omid, Kraskouski, Aliaksandr, Amalraj, John, Cai, Xiaoming, Lu, Jianmei, Zheng, Huizhen, Li, Ruibin, Xie, Maomao, Gao, Meng, Yun, Yang, Malmsten, Martin, Rotello, Vincent M. M., Zboril, Radek, Akhavan, Omid, Kraskouski, Aliaksandr, Amalraj, John, Cai, Xiaoming, Lu, Jianmei, Zheng, Huizhen, and Li, Ruibin

Abstract

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

Published
2023

2. Aerogels as promising materials for antibacterial applications: a mini-review

Author

Huseyin Deveci, Elena Aznar, Ramón Martínez-Máñez, and Gulcihan Guzel Kaya

Subjects
Materials science, Biocompatibility, CELLULOSE AEROGELS, Biomedical Engineering, Nanotechnology, CONTROLLED-RELEASE, SILVER NANOPARTICLES, engineering.material, ENHANCED ANTIBACTERIAL, Mini review, Coating, MESOPOROUS SILICA NANOPARTICLES, General Materials Science, DRUG-DELIVERY, Porosity, ANTIMICROBIAL RESISTANCE, CARBON AEROGELS, NANOCOMPOSITE AEROGELS, Anti-Bacterial Agents, Resistant bacteria, IN-SITU SYNTHESIS, engineering, Surface modification, Pharmaceutics, Antibacterial activity, Gels
Abstract

The increasing cases of bacterial infections originating from resistant bacteria are a serious problem globally and many approaches have been developed for different purposes to treat bacterial infections. Aerogels are a novel class of smart porous materials composed of three-dimensional networks. Recently, aerogels with the advantages of ultra-low density, high porosity, tunable particle and pore sizes, and biocompatibility have been regarded as promising carriers for the design of delivery systems. Recently, aerogels have also been provided with antibacterial activity through loading of antibacterial agents, incorporation of metal/metal oxides and via surface functionalization and coating with various functional groups. In this mini-review, the synthesis of aerogels from both conventional and low-cost precursors is reported and examples of aerogels displaying antibacterial properties are summarized. As a result, it is clear that the encouraging antibacterial performance of aerogels promotes their use in many antibacterial applications, especially in the food industry, pharmaceutics and medicine.

Published
2021
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