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2,348 results on '"ESPOSITO L."'

1. Design and early operation of a new-generation internal beam dump for CERN's Super Proton Synchrotron

Author

Francia, A. Romero, Marcone, A. Perillo, Pianese, S., Andersen, K., Izquierdo, G. Arnau, Briz, J. A., Perez, D. Carbajo, Carlier, E., Coiffet, T., Esposito, L. S., Grenard, J. L., Grenier, D., Humbert, J., Kershaw, K., Lendaro, J., Rolo, A. Ortega, Scibor, K., Senajova, D., Sgobba, S., Sharp, C., Steyaert, D., Velotti, F. M., Vincke, H., Vlachoudis, V., and Calviani, M.

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The Super Proton Synchrotron (SPS) is the last stage in the injector chain for CERN's Large Hadron Collider, and it also provides proton and ion beams for several fixed-target experiments. The SPS has been in operation since 1976, and it has been upgraded over the years. For the SPS to operate safely, its internal beam dump must be able to repeatedly absorb the energy of the circulating beams without sustaining damage that would affect its function. The latest upgrades of the SPS led to the requirement for its beam dump to absorb proton beams with a momentum spectrum from 14 to 450~GeV/$c$ and an average beam power up to $\sim$270~kW. This paper presents the technical details of a new design of SPS beam dump that was installed in one of the long straight sections of the SPS during the 2019--2020 shutdown of CERN's accelerator complex. This new beam dump has been in operation since May 2021, and it is foreseen that it will operate with a lifetime of 20~years. The key challenges in the design of the beam dump were linked to the high levels of thermal energy to be dissipated -- to avoid overheating and damage to the beam dump itself -- and high induced levels of radiation, which have implications for personnel access to monitor the beam dump and repair any problems occurring during operation. The design process therefore included extensive thermomechanical finite-element simulations of the beam-dump core and its cooling system's response to normal operation and worst-case scenarios for beam dumping. To ensure high thermal conductivity between the beam-dump core and its water-cooling system, hot isostatic pressing techniques were used in its manufacturing process. A comprehensive set of instrumentation was installed in the beam dump to monitor it during operation and to cross-check the numerical models with operational feedback., Comment: 20 pages, 36 figures, submitted to Phys. Rev. Accel. Beams

Published
2023
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2. Power deposition studies for standard and crystal-assisted heavy ion collimation inthe CERN Large Hadron Collider

Author

Potoine, J. B., Bruce, R., Cai, R., Cerutti, F., D'Andrea, M., Esposito, L., Hermes, P. D., Lechner, A., Mirarchi, D., Redaelli, S., Rodin, V., Pujo, F. Salvat, Schoofs, P., Waets, A., and Wrobel, F.

Subjects
Physics - Accelerator Physics
Abstract

The LHC heavy-ion program with $^{208}$Pb$^{82+}$ beams will benefit from a significant increase of the beam intensity when entering its High-Luminosity era in Run~3 (2023). The stored energy is expected to surpass 20~MJ per beam. The LHC is equipped with a betatron collimation system, which intercepts the transverse beam halo and protects sensitive equipment such as superconducting magnets against beam losses. However, nuclear fragmentation and electromagnetic dissociation of $^{208}$Pb$^{82+}$ ions in collimators generates a flux of secondary fragments, which are lost in downstream dispersion suppressor and arc cells. These secondary ions may pose a performance limitation in upcoming runs since they can induce magnet quenches. In order to mitigate this risk, an alternative collimation technique, relying on bent crystals as primary collimators, will be used in forthcoming heavy-ion runs. In this paper, we study the power deposition in superconducting magnets by means of tracking and \textsc{FLUKA} shower simulations, comparing the standard collimation system against the crystal-based one. In order to quantify the predictive ability of the simulation model, we present absolute benchmarks against beam loss monitor measurements from the 2018 $^{208}$Pb$^{82+}$ run at 6.37~$Z$TeV. The benchmarks cover several hundred meters of beamline, from the primary collimators to the first arc cells. Based on these studies, we provide a detailed analysis of ion fragmentation and leakage to the cold magnets and quantify the expected quench margin in future $^{208}$Pb$^{82+}$ runs., Comment: 20 pages, 19 figures

Published
2023

3. Measurement of transverse beam emittance of split beams for the CERN Proton Synchrotron Multi-Turn Extraction

Author

Russo, G., Cerutti, F., Esposito, L. S., Franchetti, G., Giovannozzi, M., Hunt, J. R., and Huschauer, A.

Subjects
Physics - Accelerator Physics
Abstract

Crossing a horizontal nonlinear resonance is the approach that can be used to split a beam in several beamlets with the goal to perform multi-turn extraction from a circular particle accelerator. Such an approach has been successfully implemented in the CERN Proton Synchrotron and is used routinely for the production of high-intensity proton beams for fixed-target physics at the Super Proton Synchrotron. Recently, thanks to the deployment of diamond detectors, originally installed to monitor the beam losses at extraction, it has been possible to measure the horizontal beam emittance of the split beam just prior to extraction. This is the first time that an emittance measurement is attempted for split beams, i.e. in a regime of highly nonlinear beam dynamics. In this paper, the technique is presented and its application to the analysis of the experimental data is presented and discussed in detail. This result is essential for the performance assessment of the splitting process and for the design of further performance improvements.

Published
2022

4. Multiple scattering of channeled and non-channeled positively charged particles in bent monocrystalline silicon

Author

Scandale, W., Arduini, G., Cerutti, F., Esposito, L. S., Garattini, M., Gilardoni, S., Losito, R., Masi, A., Mirarchi, D., Montesano, S., Redaelli, S., Rossi, R., Smirnov, G., Burmistrov, L., Dubos, S., Puill, V., Stocchi, A., Bandiera, L., Guidi, V., Mazzolari, A., Romagnoni, M., Murtas, F., Addesa, F., Cavoto, G., Iacoangeli, F., Galluccio, F., Afonin, A. G., Chesnokov, Yu. A., Durum, A. A., Maisheev, V. A., Sandomirskiy, Yu. E., Yanovich, A. A., Kovalenko, A. D., Taratin, A. M., Denisov, A. S., Gavrikov, Yu. A., Ivanov, Yu. M., Malyarenko, L. G., Borg, J., James, T., Hall, G., and Pesaresi, M.

Subjects
Physics - Accelerator Physics
Abstract

We present the results of an experimental study of multiple scattering of positively charged high energy particles in bent samples of monocrystalline silicon. This work confirms the recently discovered effect of a strong reduction in the rms multiple scattering angle of particles channeled in the silicon (111) plane. The effect is observed in the plane orthogonal to the bending plane. We show in detail the influence of angular constraints on the magnitude of the effect. Comparison of the multiple scattering process at different energies indicates a violation of the law of inverse proportionality of the rms angle of channeled particles with energy. By increasing the statistics, we have improved the results of multiple scattering measurements for particles moving, but not channeled, in silicon crystals., Comment: arXiv admin note: text overlap with arXiv:1910.00250 minor fixes

Published
2022

6. Beam merging assisted by a bent crystal

Author

Scandale, W., Cerutti, F., Esposito, L. S., Gilardoni, S., Losito, R., Smirnov, G. I., Giribono, A., Bauce, M., Collamati, F., Valente, P., Variola, A., Galluccio, F., Hall, G., Pesaresi, M., Uchida, K., and Rossi, R.

Published
2023
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8. Double-crystal measurements at the CERN SPS

Author

Scandale, W., Arduini, G., Cerutti, F., D'Andrea, M., Esposito, L. S., Garattini, M., Gilardoni, S., Mirarchi, D., Montesano, S., Natochii, A., Redaelli, S., Rossi, R., Smirnov, G. I., Burmistrov, L., Dubos, S., Puill, V., Stocchi, A., Addesa, F., Murtas, F., Galluccio, F., Kovalenko, A. D., Taratin, A. M., Denisov, A. S., Gavrikov, Yu. A., Ivanov, Yu. M., Lapina, L. P., Malyarenko, L. G., Skorobogatov, V. V., Afonin, A. G., Chesnokov, Yu. A., Durum, A. A., Maisheev, V. A., Sandomirskiy, Yu. E., Yanovich, A. A., Borg, J., James, T., Hall, G., and Pesaresi, M.

Subjects
Physics - Accelerator Physics
Abstract

The UA9 setup, installed in the Super Proton Synchrotron (SPS) at CERN, was exploited for a proof of principle of the double-crystal scenario, proposed to measure the electric and the magnetic moments of short-lived baryons in a high-energy hadron collider, such as the Large Hadron Collider (LHC). Linear and angular actuators were used to position the crystals and establish the required beam configuration. Timepix detectors and high-sensitivity Beam Loss Monitors were exploited to observe the deflected beams. Linear and angular scans allowed exploring the particle interactions with the two crystals and recording their efficiency. The measured values of the beam trajectories, profiles and of the channeling efficiency agree with the results of a Monte-Carlo simulation., Comment: 25 pages, 13 figures

Published
2021
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10. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: Insights from the START study

Author

Steering Committee, De Luca (Chairman), L., Gulizia (co-chairman), M.M., Temporelli, P.L., Riccio, C., Colivicchi, F., Amico, A.F., Formigli, D., Geraci, G., Di Lenarda, A., Executive Committee, De Luca, L., Maggioni, A.P., Lucci, D., Coordinating Center, Lorimer, A., Orsini, G., Gonzini, L., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabrò, P., Bianchi, R., Di Palma, G., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Magliari, F., Callerame, M., Mazzella, T., Lettica, G.V., Coco, G., Incao, F., Marinacci, L., D'Addario, S., Tartaglione, S.N., Ubaldi, S., Sanchez, F.A., Costa, P., Manca, G., Failla, M., Scherillo, M., Procaccini, V., Senni, M., Luminita, E.M., Bonomo, P., Mossa, C., Corda, S., Colavita, A.R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I.L., De Rosa, F.M., Fontana, F., Fuscaldo, G.F., Passamonti, E., Bertella, E., Calvaruso, E.V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Biase, M Di, Brunetti, N.D., Gallotta, A.M., Mattei, L., Marini, R., Balsemin, F., Urbano, M.D., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M.M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M.G., Raisaro, A.E., Di Giacomo, C., Somaschini, A., Fasano, M.L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T.A., Malanchini, G., Del Corral, M.P., Tedesco, L., Pede, S., Urso, L.G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M.S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Mastroianno, S., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Valle, C Dalla, Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M.F., Multari, E.I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A.S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N.A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C.M., Marchetti, M., Grisolia, E Franceschini, Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R.A., Filippis, M De, Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V.M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S.R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Gulizia, M.M., Francese, G.M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., Vecchis, M De, Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., La Fata, B., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M.G., Berti, S., Lo Surdo, G., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M.R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Proietti, F., Di Croce, G., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Gervasio, F., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M.R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M.A., Corrado, V.M., Spagnolo, D., Caico, S.I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Lo Bianco, F., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., De Luca, Leonardo, Temporelli, Pier Luigi, Gulizia, Michele Massimo, Gonzini, Lucio, Ammaturo, Tiziana Anita, Tedesco, Luigi, Pede, Silvia, Oliva, Fabrizio, Gabrielli, Domenico, Colivicchi, Furio, and Averna, Maurizio R.

Published
2023
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11. Reduction of multiple scattering of high-energy positively charged particles during channeling in single crystals

Author

Scandale, W., Esposito, L. S., Garattini, M., Rossi, R., Zhovkovska, V., Natochii, A., Addesa, F., Iacoangeli, F., Galluccio, F., Murtas, F., Afonin, A. G., Chesnokov, Yu. A., Durum, A. A., Maisheev, V. A., Sandomirskiy, Yu. E., Yanovich, A. A., Smirnov, G. I., Gavrikov, Yu. A., Ivanov, Yu. M., Koznov, M. A., Malkov, M. V., Malyarenko, L. G., Mamunct, I. G., Borg, J., James, T., Hall, G., and Pesaresi, M.

Subjects
Physics - Accelerator Physics
Abstract

We present the experimental observation of the reduction of multiple scattering of high-energy positively charged particles during channeling in single crystals. According to our measurements the rms angle of multiple scattering in the plane orthogonal to the plane of the channeling is less than half that for non-channeled particles moving in the same crystal. In the experiment we use focusing bent single crystals. Such crystals have a variable thickness in the direction of beam propagation. This allows us to measure rms angles of scattering as a function of thickness for channeled and non-channeled particles. The behaviour with thickness of non-channeled particles is in agreement with expectations whereas the behaviour of channeled particles has unexpected features. We give a semi-quantitative explanation of the observed effect., Comment: 13 pages, 7 figures

Published
2019
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12. Double-crystal setup measurements at the CERN SPS

Author

Scandale, W., Cerutti, F., Esposito, L. S., Garattini, M., Gilardoni, S., Montesano, S., Rossi, R., Burmistrov, L., Dubos, S., Natochii, A., Puill, V., Stocchi, A., Zhovkovska, V., Murtas, F., Addesa, F., Iacoangeli, F., Galluccio, F., Kovalenko, A. D., Taratin, A. M., Smirnov, G. I., Denisov, A. S., Gavrikov, Yu. A., Ivanov, Yu. M., Lapina, L. P., Malyarenko, L. G., Skorobogatov, V. V., Afonin, A. G., Chesnokov, Yu. A., Durum, A. A., Maisheev, V. A., Sandomirskiy, Yu. E., Yanovich, A. A., Borg, J., James, T., Hall, G., and Pesaresi, M.

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

In this paper, we discuss an experimental layout for the two-crystals scenario at the Super Proton Synchrotron (SPS) accelerator. The research focuses on a fixed target setup at the circulating machine in a frame of the Physics Beyond Colliders (PBC) project at CERN. The UA9 experiment at the SPS serves as a testbench for the proof of concept, which is planning to be projected onto the Large Hadron Collider (LHC) scale. The presented in the text configuration was used for the quantitative characterization of the deflected particle beam by a pair of bent silicon crystals. For the first time in the double-crystal configuration, a particle deflection efficiency by the second crystal of $0.188 \pm 3 \cdot 10^{-5}$ and $0.179 \pm 0.013$ was measured on the accelerator by means of the Timepix detector and Beam Loss Monitor (BLM) respectively. In this setup, a wide range angular scan allowed a possibility to \textit{in situ} investigate different crystal working regimes (channeling, volume reflection, etc.), and to measure a bent crystal torsion., Comment: 6 pages, 8 figures. To be submitted to PLB

Published
2019

13. Commissioning and operation of the Cherenkov detector for proton Flux Measurement of the UA9 Experiment

Author

Addesa, F. M., Burmistrov, L., Breton, D., Cavoto, G., Chaumat, V., Dubos, S., Esposito, L., Galluccio, F., Garattini, M., Iacoangeli, F., Maalmi, J., Mirarchi, D., Natochii, A., Puill, V., Rossi, R., Scandale, W., Montesano, S., and Stocchi, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Physics - Accelerator Physics
Abstract

The UA9 Experiment at CERN-SPS investigates channeling processes in bent silicon crystals with the aim to manipulate hadron beams. Monitoring and characterization of channeled beams in the high energy accelerators environment ideally requires in-vacuum and radiation hard detectors. For this purpose the Cherenkov detector for proton Flux Measurement (CpFM) was designed and developed. It is based on thin fused silica bars in the beam pipe vacuum which intercept charged particles and generate Cherenkov light. The first version of the CpFM is installed since 2015 in the crystal-assisted collimation setup of the UA9 experiment. In this paper the procedures to make the detector operational and fully integrated in the UA9 setup are described. The most important standard operations of the detector are presented. They have been used to commission and characterize the detector, providing moreover the measurement of the integrated channeled beam profile and several functionality tests as the determination of the crystal bending angle. The calibration has been performed with Lead (Pb) and Xenon (Xe) beams and the results are applied to the flux measurement discussed here in detail., Comment: 25 pages, 14 figures

Published
2019
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17. Preliminary Modeling Of Radiation Levels At The Fermilab PIP-II Linac

Author

Lari, L., Cerutti, F., Esposito, L. S., Baffes, C., Dixon, S. J., Mokhov, N. V., Rakhno, I., and Tropin, I. S.

Subjects
Physics - Accelerator Physics
Abstract

PIP-II is the Fermilab's flagship project for providing powerful, high-intensity proton beams to the laboratory's experiments. The heart of PIP-II is an 800-MeV superconducting linac accelerator. It will be located in a new tunnel with new service buildings and connected to the present Booster through a new transfer line. To support the design of civil engineering and mechanical integration, this paper provides preliminary estimation of radiation level in the gallery at an operational beam loss limit of 0.1 W/m, by means of Monte Carlo calculations with FLUKA and MARS15 codes., Comment: 4 pp. Proceedings of IPAC2018, Vancouver, BC, Canada

Published
2018

19. Energy Deposition and Radiation to Electronics

Author

Bignami, A., Broggi, F., Brugger, M., Cerutti, F., Esposito, L. S., Lechner, A., Mokhov, N. V., Rakhno, I. L., Santini, C., Skordis, E., and Tropin, I. S.

Subjects
Physics - Accelerator Physics
Abstract

Chapter 10 in High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report. The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC., Comment: 16 pages, chapter 10 in High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report. arXiv admin note: text overlap with arXiv:1504.00594

Published
2017
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20. Collimation System

Author

Appleby, R. B., Barlow, R., Bertarelli, A., Bruce, R., Carra, F., Cerutti, F., Esposito, L., Faus-Golfe, A., Morales, H. Garcia, Gentini, L., Gibson, S. M., Gradassi, P., Jowett, J. M., Kwee-Hinzmann, R., Lari, L., Lechner, A., Markiewicz, T., Marsili, A., Molson, J., Nevay, L. J., Quaranta, E., Rafique, H., Redaelli, S., Serluca, M., Skordis, E., Stancari, G., Steele, G., and Toader, A.

Subjects
Physics - Accelerator Physics
Abstract

Chapter 5 in High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report. The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC., Comment: 22 pages, chapter 5 in High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

Published
2017
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21. Design and early operation of a new-generation internal beam dump for CERN’s Super Proton Synchrotron

Author

Francia, A. Romero, primary, Marcone, A. Perillo, additional, Pianese, S., additional, Andersen, K., additional, Izquierdo, G. Arnau, additional, Briz, J. A., additional, Perez, D. Carbajo, additional, Carlier, E., additional, Coiffet, T., additional, Esposito, L. S., additional, Grenard, J. L., additional, Grenier, D., additional, Humbert, J., additional, Kershaw, K., additional, Lendaro, J., additional, Rolo, A. Ortega, additional, Scibor, K., additional, Senajova, D., additional, Sgobba, S., additional, Sharp, C., additional, Steyaert, D., additional, Velotti, F. M., additional, Vincke, H., additional, Vlachoudis, V., additional, and Calviani, M., additional

Published
2024
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25. Energy deposition studies for the High-Luminosity Large Hadron Collider inner triplet magnets

Author

Mokhov, N. V., Rakhno, I. L., Tropin, I. S., Cerutti, F., Esposito, L. S., and Lechner, A.

Subjects
Physics - Accelerator Physics
Abstract

A detailed model of the High Luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the FLUKA and MARS15 codes. In the optimized configuration, the peak power density averaged over the magnet inner cable width is safely below the quench limit. For the integrated luminosity of 3000 fb-1, the peak dose in the innermost magnet insulator ranges from 20 to 35 MGy. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. In general, FLUKA and MARS results are in a very good agreement., Comment: 24 pp

Published
2015
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26. Energy Deposition Studies for the Hi-Lumi LHC Inner Triplet Magnets

Author

Mokhov, N. V., Rakhno, I. L., Striganov, S. I., Tropin, I. S., Cerutti, F., Esposito, L., and Lechner, A.

Subjects
Physics - Accelerator Physics
Abstract

A detailed model of the High Luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the FLUKA and MARS15 codes. In the optimized configuration, the peak power density averaged over the magnet inner cable width is safely below the quench limit. For the integrated luminosity of 3000 fb -1, the peak dose in the innermost magnet insulator ranges from 20 to 35 MGy. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. In general, FLUKA and MARS results are in a very good agreement., Comment: 4 pp. Presented paper at the 5th International Particle Accelerator Conference, June 15 -20, 2014, Dresden, Germany

Published
2015

30. The Neumann eigenvalue problem for the $\infty$-Laplacian

Author

Esposito, L., Kawohl, B., Nitsch, C., and Trombetti, C.

Subjects
Mathematics - Analysis of PDEs, 35P30, 35P15, 35J72, 35D40, 35J92, 35J70
Abstract

The first nontrivial eigenfunction of the Neumann eigenvalue problem for the $p$-Laplacian, suitable normalized, converges as $p$ goes to $\infty$ to a viscosity solution of an eigenvalue problem for the $\infty$-Laplacian. We show among other things that the limit of the eigenvalue, at least for convex sets, is in fact the first nonzero eigenvalue of the limiting problem. We then derive a number of consequences, which are nonlinear analogues of well-known inequalities for the linear (2-)Laplacian., Comment: Corrected few typos. Corollary 5 added

Published
2014

31. Green electrochemical polishing of EBM Ti6Al4V samples with preliminary fatigue results

Author

Acquesta A., Monetta T., Franchitti S., Borrelli R., Viscusi A., Perna A. S., Penta F., Esposito L., Carrino L., Acquesta, A., Monetta, T., Franchitti, S., Borrelli, R., Viscusi, A., Perna, A. S., Penta, F., Esposito, L., and Carrino, L.

Subjects
Electropolishing treatment, Additive manufacturing, Control and Systems Engineering, Mechanical Engineering, Eco-friendly treatment, Fatigue property, Roughness, Industrial and Manufacturing Engineering, Software, Computer Science Applications
Abstract

Additive manufacturing technologies have several well-known advantages; however, the surface quality of the printed parts is poor, compromising the corrosion and mechanical properties. Thus, surface finishing treatments are necessary. The most post-processing treatments proposed in the literature are mechanical or chemical. The formers are contact techniques and cannot be suitable for complex geometry, while the latter use strong and dangerous reagents. This paper is aimed to investigate the effect of the electropolishing treatment, a contactless technique, using an eco-friendly electrolytic solution in reducing the roughness and improving the fatigue properties of Ti6Al4V specimens produced by electron beam melting technology. Several parameters affecting the effectiveness of the electropolishing treatment have been investigated, as interelectrode distance, stirring rate and duration time. An optimal combination of them allowed a uniform surface treatment and a significant roughness reduction (64% of Sa reduction for cylindrical specimens). Under sinusoidal loading conditions with a maximum stress of 378 MPa and a stress ratio equal to R = 0.1, the mean fatigue life of electropolished dog-bone specimens was 250% longer than that of as-built specimens.

Published
2023

34. Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register (Internal and Emergency Medicine, (2023), 18, 4, (1049-1063), 10.1007/s11739-023-03254-3)

Author

Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

In this article the names of a few collaborators and some data in Table 5 were missing. It has been corrected. The original article has been corrected.

Published
2023

35. Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Author

Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., Pace E., Succurro, E, Novella, A, Nobili, A, Giofre, F, Arturi, F, Sciacqua, A, Andreozzi, F, Pietrangelo, A, Sesti, G, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Miglio, G, Ardoino, I, Cantiero, S, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Mazzetti, M, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Martini, I, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Orio, G, Magnolfi, E, Serafini, G, Brunori, M, Lazzari, I, Simili, A, Fabio, G, De Amicis, M, Luca, G, Scaramellini, N, Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Sabatino, A, Miceli, E, Pisati, M, Pitotti, L, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Rossi, I, Valeriani, E, D'Ardes, D, Cipollone, A, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Manetti, R, Sircana, M, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Geneletti, T, Picardi, A, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Tassone, B, De Falco, A, Negro, E, Brenna, M, Trotta, L, Fabris, F, Bertozzi, I, Bogoni, G, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Reni, E, Manfredini, R, Boari, B, Tiseo, R, Savrie, C, Fabbian, F, Paolisso, G, Catalano, C, Meo, I, Sabba, C, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Barnaba, I, Schilardi, A, Fenoglio, L, Falcetta, A, D'Aniano, S, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Colavolpe, L, Curra, J, Alletto, F, Benzoni, G, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Canetta, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Tognin, T, Purrello, F, Pino, A, Piro, S, Rozzini, R, Falanga, L, Boffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Dentali, F, Behnke, V, Perticone, M, Maio, R, Scozzafava, A, Condoleo, V, Clausi, E, Armentaro, G, Panza, A, Stanghellini, V, Ruggeri, E, Vecchio, S, Benzoni, I, Minisola, S, Colangelo, L, Cilli, M, Labbadia, G, Pepe, J, Castellino, P, Zanoli, L, Gaudio, A, Xourafa, A, Spichetti, C, Torre, S, Gennaro, A, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Famularo, G, Tarsitani, P, Morretti, T, Aglitti, A, Giacco, S, Firinu, D, Costanzo, G, Chessa, S, Montalto, G, Licata, A, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Cocuzza, A, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Pirisi, M, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Coviello, F, Catalini, C, Pilotto, A, Indiano, I, Gandolfo, F, Gonella, D, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Durante, V, Tirotta, D, Eusebi, G, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Gino, M, Pari, B, Pace, E, Succurro E., Novella A., Nobili A., Giofre F., Arturi F., Sciacqua A., Andreozzi F., Pietrangelo A., Sesti G., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Miglio G., Ardoino I., Cantiero S., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Mazzetti M., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Martini I., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Orio G., Magnolfi E., Serafini G., Brunori M., Lazzari I., Simili A., Fabio G., De Amicis M. M., Luca G., Scaramellini N., Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Sabatino A., Miceli E., Pisati M., Pitotti L., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Rossi I., Valeriani E., D'Ardes D., Cipollone A., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Manetti R., Sircana M., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Geneletti T., Picardi A., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Tassone B., De Falco A. B. T., Negro E., Brenna M., Trotta L., Fabris F., Bertozzi I., Bogoni G., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Reni E., Manfredini R., Boari B., Tiseo R., Savrie C., Fabbian F., Paolisso G., Catalano C., Meo I., Sabba C., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Barnaba I., Schilardi A., Fenoglio L., Falcetta A., D'Aniano S., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Colavolpe L., Curra J., Alletto F., Benzoni G., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Canetta C., Monzani V., Savojardo V., Ceriani G., Folli C., Tognin T., Purrello F., Pino A., Piro S., Rozzini R., Falanga L., Boffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Dentali F., Behnke V., Perticone M., Maio R., Scozzafava A., Condoleo V., Clausi E., Armentaro G., Panza A., Stanghellini V., Ruggeri E., Vecchio S., Benzoni I., Minisola S., Colangelo L., Cilli M., Labbadia G., Pepe J., Castellino P., Zanoli L., Gaudio A., Xourafa A., Spichetti C., Torre S., Gennaro A., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Famularo G., Tarsitani P., Morretti T., Aglitti A., Giacco S., Firinu D., Costanzo G., Chessa S., Montalto G., Licata A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Cocuzza A., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Pirisi M., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Coviello F., Catalini C., Pilotto A., Indiano I., Gandolfo F., Gonella D., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Durante V., Tirotta D., Eusebi G., Tresoldi M., Bozzolo E., Damanti S., Porta M., Gino M., Pari B., and Pace E.

Abstract

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie–Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria.

Published
2023

36. Structure of Starch–Sepiolite Bio-Nanocomposites: Effect of Processing and Matrix–Filler Interactions

Author

Bugnotti, D, Dalle Vacche, S, Esposito, L, Callone, E, Orsini, S, Ceccato, R, D’Arienzo, M, Bongiovanni, R, Dirè, S, Vitale, A, Bugnotti D., Dalle Vacche S., Esposito L. H., Callone E., Orsini S. F., Ceccato R., D’Arienzo Massimiliano, Bongiovanni R., Dirè S., Vitale A., Bugnotti, D, Dalle Vacche, S, Esposito, L, Callone, E, Orsini, S, Ceccato, R, D’Arienzo, M, Bongiovanni, R, Dirè, S, Vitale, A, Bugnotti D., Dalle Vacche S., Esposito L. H., Callone E., Orsini S. F., Ceccato R., D’Arienzo Massimiliano, Bongiovanni R., Dirè S., and Vitale A.

Abstract

Sepiolite clay is a natural filler particularly suitable to be used with polysaccharide matrices (e.g., in starch-based bio-nanocomposites), increasing their attractiveness for a wide range of applications, such as packaging. Herein, the effect of the processing (i.e., starch gelatinization, addition of glycerol as plasticizer, casting to obtain films) and of the sepiolite filler amount on the microstructure of starch-based nanocomposites was investigated by SS-NMR (solid-state nuclear magnetic resonance), XRD (X-ray diffraction) and FTIR (Fourier-transform infrared) spectroscopy. Morphology, transparency and thermal stability were then assessed by SEM (scanning electron microscope), TGA (thermogravimetric analysis) and UV–visible spectroscopy. It was demonstrated that the processing method allowed to disrupt the rigid lattice structure of semicrystalline starch and thus obtain amorphous flexible films, with high transparency and good thermal resistance. Moreover, the microstructure of the bio-nanocomposites was found to intrinsically depend on complex interactions among sepiolite, glycerol and starch chains, which are also supposed to affect the final properties of the starch–sepiolite composite materials.

Published
2023

37. Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study

Author

Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., Zotti S., Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., and Zotti S.

Abstract

Background: The prevalence of hypothyroidism among older patients hospitalized for COVID-19 and its association with mortality is unclear. This study aims to investigate the prevalence of hypothyroidism in older COVID-19 inpatients and verify if this comorbidity is associated with a specific pattern of onset symptoms and a worse prognosis. Methods: COVID-19 inpatients aged ≥ 60 years, participating in the GeroCovid acute wards cohort, were included. The history of hypothyroidism was derived from medical records and the use of thyroid hormones. Sociodemographic data, comorbidities, symptoms/signs at the disease onset and inflammatory markers at ward admission were compared between people with vs without history of hypothyroidism. The association between hypothyroidism and in-hospital mortality was tested through Cox regression. Results: Of the 1245 patients included, 8.5% had a history of hypothyroidism. These patients were more likely to present arterial hypertension and obesity compared with those without an history of hypothyroidism. Concerning COVID-19 clinical presentation, patients with hypothyroidism had less frequently low oxygen saturation and anorexia but reported muscle pain and loss of smell more commonly than those without hypothyroidism. Among the inflammatory markers, patients with hypothyroidism had higher lymphocytes values. At Cox regression, hypothyroidism was associated with reduced in-hospital mortality only in the univariable model (HR = 0.66, 95% CI 0.45–0.96, p = 0.03); conversely, no significant result were observed after adjusting for potential confounders (HR = 0.69, 95% CI 0.47–1.03, p = 0.07). Conclusions: Hypothyroidism does not seem to substantially influence the prognosis of COVID-19 in older people, although it may be associated with peculiar clinical and biochemical features at the disease onset.

Published
2023

38. Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study

Author

Coin, A, Noale, M, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Abbatecola, A, Del Signore, S, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Andrieri, D, Antognoli, R, Antonietti, M, Bagalà, V, Bandini, G, Bazzano, S, Bellotti, F, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bianchi, P, Biasin, F, Bignamini, S, Blandini, D, Boffelli, S, Bontempi, C, Bordignon, A, Bracchitta, L, Bugada, M, Cafariello, C, Caleri, V, Calsolaro, V, Calvani, D, Campagna, F, Capasso, A, Capurso, S, Carino, S, Carpagnano, E, Carrieri, B, Castaldo, V, Castelli, M, Castellino, M, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Ceretti, A, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Colombo, M, Corsi, A, Crispino, A, Cucunato, R, Custodero, C, D’Agostino, F, D’Errico, M, D’Amico, F, De Iorio, A, De Marchi, A, Dell’Armi, A, Delmonte, M, Desideri, G, Devita, M, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Ferro, C, Filippini, C, Fiore, L, Fiorillo, S, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Gasbarri, P, Giordano, A, Giuliani, E, Granata, R, Coin A., Noale M., Gareri P., Trevisan C., Bellio A., Fini F., Abbatecola A. M., Del Signore S., Malara A., Mossello E., Fumagalli S., Volpato S., Monzani F., Bellelli G., Zia G., Incalzi R. A., Andrieri D., Antognoli R., Antonietti M. P., Bagalà V., Bandini G., Bazzano S., Bellotti F., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bianchi P., Biasin F., Bignamini S., Blandini D., Boffelli S., Bontempi C., Bordignon A., Bracchitta L. M., Bugada M., Cafariello C., Caleri V., Calsolaro V., Calvani D., Campagna F. A., Capasso A., Capurso S., Carino S., Carpagnano E., Carrieri B., Castaldo V., Castelli M., Castellino M., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Ceretti A., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Colombo M., Corsi A., Crispino A., Cucunato R., Custodero C., D’Agostino F., D’Errico M. M., D’Amico F., De Iorio A., De Marchi A., Dell’Armi A., Delmonte M., Desideri G., Devita M., Di Matteo E., Espinosa E., Esposito L., Fazio C., Ferro C., Filippini C., Fiore L., Fiorillo S., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Gasbarri P. P., Giordano A., Giuliani E., Granata R., Coin, A, Noale, M, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Abbatecola, A, Del Signore, S, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Andrieri, D, Antognoli, R, Antonietti, M, Bagalà, V, Bandini, G, Bazzano, S, Bellotti, F, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bianchi, P, Biasin, F, Bignamini, S, Blandini, D, Boffelli, S, Bontempi, C, Bordignon, A, Bracchitta, L, Bugada, M, Cafariello, C, Caleri, V, Calsolaro, V, Calvani, D, Campagna, F, Capasso, A, Capurso, S, Carino, S, Carpagnano, E, Carrieri, B, Castaldo, V, Castelli, M, Castellino, M, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Ceretti, A, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Colombo, M, Corsi, A, Crispino, A, Cucunato, R, Custodero, C, D’Agostino, F, D’Errico, M, D’Amico, F, De Iorio, A, De Marchi, A, Dell’Armi, A, Delmonte, M, Desideri, G, Devita, M, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Ferro, C, Filippini, C, Fiore, L, Fiorillo, S, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Gasbarri, P, Giordano, A, Giuliani, E, Granata, R, Coin A., Noale M., Gareri P., Trevisan C., Bellio A., Fini F., Abbatecola A. M., Del Signore S., Malara A., Mossello E., Fumagalli S., Volpato S., Monzani F., Bellelli G., Zia G., Incalzi R. A., Andrieri D., Antognoli R., Antonietti M. P., Bagalà V., Bandini G., Bazzano S., Bellotti F., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bianchi P., Biasin F., Bignamini S., Blandini D., Boffelli S., Bontempi C., Bordignon A., Bracchitta L. M., Bugada M., Cafariello C., Caleri V., Calsolaro V., Calvani D., Campagna F. A., Capasso A., Capurso S., Carino S., Carpagnano E., Carrieri B., Castaldo V., Castelli M., Castellino M., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Ceretti A., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Colombo M., Corsi A., Crispino A., Cucunato R., Custodero C., D’Agostino F., D’Errico M. M., D’Amico F., De Iorio A., De Marchi A., Dell’Armi A., Delmonte M., Desideri G., Devita M., Di Matteo E., Espinosa E., Esposito L., Fazio C., Ferro C., Filippini C., Fiore L., Fiorillo S., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Gasbarri P. P., Giordano A., Giuliani E., and Granata R.

Abstract

Background and objectives: Depression is highly prevalent in older adults, especially in those with dementia. Trazodone, an antidepressant, has shown to be effective in older patients with moderate anxiolytic and hypnotic activity; and a common off-label use is rising for managing behavioral and psychological symptoms of dementia (BPSD). The aim of the study is to comparatively assess the clinical profiles of older patients treated with trazodone or other antidepressants. Methods: This cross-sectional study involved adults aged ≥ 60 years at risk of or affected with COVID-19 enrolled in the GeroCovid Observational study from acute wards, geriatric and dementia-specific outpatient clinics, as well as long-term care facilities (LTCF). Participants were grouped according to the use of trazodone, other antidepressants, or no antidepressant use. Results: Of the 3396 study participants (mean age 80.6 ± 9.1 years; 57.1% females), 10.8% used trazodone and 8.5% others antidepressants. Individuals treated with trazodone were older, more functionally dependent, and had a higher prevalence of dementia and BPSD than those using other antidepressants or no antidepressant use. Logistic regression analyses found that the presence of BPSD was associated with trazodone use (odds ratio (OR) 28.4, 95% confidence interval (CI) 18-44.7 for the outcome trazodone vs no antidepressants use, among participants without depression; OR 2.17, 95% CI 1.05-4.49 for the outcome trazodone vs no antidepressants use, among participants with depression). A cluster analysis of trazodone use identified three clusters: cluster 1 included mainly women, living at home with assistance, multimorbidity, dementia, BPSD, and depression; cluster 2 included mainly institutionalized women, with disabilities, depression, and dementia; cluster 3 included mostly men, often living at home unassisted, with better mobility performance, fewer chronic diseases, dementia, BPSD, and depression. Discussion: The use of trazodo

Published
2023

39. Measurements of Production Properties of K0S mesons and Lambda hyperons in Proton-Carbon Interactions at 31 GeV/c

Author

Abgrall, N., Aduszkiewicz, A., Ali, Y., Anticic, T., Antoniou, N., Argyriades, J., Baatar, B., Blondel, A., Blumer, J., Bogomilov, M., Bravar, A., Brooks, W., Brzychczyk, J., Bunyatov, S. A., Busygina, O., Christakoglou, P., Czopowicz, T., Davis, N., Debieux, S., Dembinski, H., Diakonos, F., Di Luise, S., Dominik, W., Drozhzhova, T., Dumarchez, J., Dynowski, K., Engel, R., Ereditato, A., Esposito, L., Feofilov, G. A., Fodor, Z., Fulop, A., Gaździcki, M., Golubeva, M., Grebieszkow, K., Grzeszczuk, A., Guber, F., Hakobyan, H., Haesler, A., Hasegawa, T., Hierholzer, M., Idczak, R., Igolkin, S., Ivanov, Y., Ivashkin, A., Jokovic, D., Kadija, K., Kapoyannis, A., Katrynska, N., Kaptur, E., Kielczewska, D., Kikola, D., Kirejczyk, M., Kisiel, J., Kiss, T., Kleinfelder, S., Kobayashi, T., Kolesnikov, V. I., Kolev, D., Kondratiev, V. P., Korzenev, A., Kowalski, S., Krasnoperov, A., Kuleshov, S., Kurepin, A., Larsen, D., Laszlo, A., Lyubushkin, V. V., Mackowiak-Pawlowska, M., Majka, Z., Maksiak, B., Malakhov, A. I., Maletic, D., Manic, D., Marchionni, A., Marcinek, A., Marin, V., Marton, K., Mathes, H. -J., Matulewicz, T., Matveev, V., Melkumov, G. L., Mrówczyński, St., Murphy, S., Nakadaira, T., Nirkko, M., Nishikawa, K., Palczewski, T., Palla, G., Panagiotou, A. D., Paul, T., Peryt, W., Pistillo, C., Redij, A., Petukhov, O., Planeta, R., Pluta, J., Popov, B. A., Posiadała, M., Puławski, S., Puzovic, J., Rauch, W., Ravonel, M., Renfordt, R., Robert, A., Röhrich, D., Rondio, E., Roth, M., Rubbia, A., Rustamov, A., Rybczynski, M., Sadovsky, A., Sakashita, K., Savic, M., Schmidt, K., Sekiguchi, T., Seyboth, P., Shibata, M., Sipos, R., Skrzypczak, E., Slodkowski, M., Staszel, P., Stefanek, G., Stepaniak, J., Susa, T., Szuba, M., Tada, M., Tereshchenko, V., Tolyhi, T., Tsenov, R., Turko, L., Ulrich, R., Unger, M., Vassiliou, M., Veberic, D., Vechernin, V. V., Vesztergombi, G., Vinogradov, L., Wilczek, A., Wlodarczyk, Z., Wojtaszek, A., Wyszyński, O., Zambelli, L., and Zipper, W.

Subjects
Physics - Accelerator Physics, Nuclear Experiment
Abstract

Spectra of K0S mesons and Lambda hyperons were measured in p+C interactions at 31 GeV/c with the large acceptance NA61/SHINE spectrometer at the CERN SPS. The data were collected with an isotropic graphite target with a thickness of 4% of a nuclear interaction length. Interaction cross sections, charged pion spectra, and charged kaon spectra were previously measured using the same data set. Results on K0S and Lambda production in p+C interactions serve as reference for the understanding of the enhancement of strangeness production in nucleus-nucleus collisions. Moreover, they provide important input for the improvement of neutrino flux predictions for the T2K long baseline neutrino oscillation experiment in Japan. Inclusive production cross sections for K0S and Lambda are presented as a function of laboratory momentum in intervals of the laboratory polar angle covering the range from 0 up to 240 mrad. The results are compared with predictions of several hadron production models. The K0S mean multiplicity in production processes and the inclusive cross section for K0S production were measured and amount to 0.127 +- 0.005 (stat) +- 0.022 (sys) and 29.0 +- 1.6 (stat) +- 5.0 (sys) mb, respectively.

Published
2013
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40. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam using the 2012 dedicated data

Author

The OPERA Collaboration, Adam, T., Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Beretta, M., Bertolin, A., Bozza, C., Brugière, T., Brugnera, R., Brunet, F., Brunetti, G., Buettner, B., Buontempo, S., Carlus, B., Cavanna, F., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Esposito, L. S., Favier, J., Felici, G., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Girerd, C., Goellnitz, C., Goldberg, J., Golubkov, D., Gornushkin, Y., Grella, G., Grianti, F., Guerin, C., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hollnagel, A., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Mancini-Terracciano, C., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Moser, U., Muciaccia, M. T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Nikitina, V., Ogawa, S., Olchevsky, A., Ozaki, K., Palamara, O., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefall, W., Schuler, J., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Wurtz, J., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., Zghiche, A., and Zimmermann, R.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

In spring 2012 CERN provided two weeks of a short bunch proton beam dedicated to the neutrino velocity measurement over a distance of 730 km. The OPERA neutrino experiment at the underground Gran Sasso Laboratory used an upgraded setup compared to the 2011 measurements, improving the measurement time accuracy. An independent timing system based on the Resistive Plate Chambers was exploited providing a time accuracy of $\sim$1 ns. Neutrino and anti-neutrino contributions were separated using the information provided by the OPERA magnetic spectrometers. The new analysis profited from the precision geodesy measurements of the neutrino baseline and of the CNGS/LNGS clock synchronization. The neutrino arrival time with respect to the one computed assuming the speed of light in vacuum is found to be $\delta t_\nu \equiv TOF_c - TOF_\nu= (0.6 \pm 0.4\ (stat.) \pm 3.0\ (syst.))$ ns and $\delta t_{\bar{\nu}} \equiv TOF_c - TOF_{\bar{\nu}} = (1.7 \pm 1.4\ (stat.) \pm 3.1\ (syst.))$ ns for $\nu_{\mu}$ and $\bar{\nu}_{\mu}$, respectively. This corresponds to a limit on the muon neutrino velocity with respect to the speed of light of $-1.8 \times 10^{-6} < (v_{\nu}-c)/c < 2.3 \times 10^{-6}$ at 90% C.L. This new measurement confirms with higher accuracy the revised OPERA result., Comment: 14 pages, 4 figures

Published
2012
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41. The T2K Neutrino Flux Prediction

Author

T2K Collaboration, Abe, K., Abgrall, N., Aihara, H., Akiri, T., Albert, J. B., Andreopoulos, C., Aoki, S., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S. W., Berardi, V., Berger, B. E., Berkman, S., Bertram, I., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blondel, A., Bojechko, C., Boyd, S., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Calland, R. G., Rodriguez, J. Caravaca, Cartwright, S. L., Castillo, R., Catanesi, M. G., Cervera, A., Cherdack, D., Christodoulou, G., Clifton, A., Coleman, J., Coleman, S. J., Collazuol, G., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davis, S., Day, M., de Andre, J. P. A. M., de Perio, P., De Rosa, G., Dealtry, T., Densham, C., Di Lodovico, F., Di Luise, S., Dobson, J., Duboyski, T., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escudero, L., Esposito, L. S., Finch, A. J., Frank, E., Friend, M., Fujii, Y., Fukuda, Y., Galymov, V., Gaudin, A., Giffin, S., Giganti, C., Gilje, K., Golan, T., Gomez-Cadenas, J. J., Gonin, M., Grant, N., Gudin, D., Guzowski, P., Hadley, D. R., Haesler, A., Haigh, M. D., Hansen, D., Hara, T., Hartz, M., Hasegawa, T., Hastings, N. C., Hayato, Y., Hearty, C., Helmer, R. L., Hignight, J., Hillairet, A., Himmel, A., Hiraki, T., Holeczek, J., Horikawa, S., Huang, K., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Ikeda, M., Imber, J., Insler, J., Ishida, T., Ishii, T., Ives, S. J., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Jo, J. H., Jonsson, P., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kanazawa, Y., Karlen, D., Karpikov, I., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kilinski, A., Kim, J. Y., Kim, J., Kim, S. B., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kowalik, K., Kreslo, I., Kropp, W., Kubo, H., Kudenko, Y., Kumaratunga, S., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laing, A., Laveder, M., Lawe, M., Lee, K. P., Licciardi, C., Lim, I. T., Lindner, T., Lister, C., Litchfield, R. P., Longhin, A., Lopez, G. D., Ludovici, L., Macaire, M., Magaletti, L., Mahn, K., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marteau, J., Martin, J. F., Maruyama, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A., Miura, M., Monfregola, L., Moriyama, S., Mueller, Th. A., Murakami, A., Murdoch, M., Murphy, S., Myslik, J., Nagasaki, T., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Naples, D., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishimura, Y., O'Keeffe, H. M., Obayashi, Y., Ohta, R., Okumura, K., Oryszczak, W., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Pac, M. Y., Palladino, V., Paolone, V., Payne, D., Pearce, G. F., Perevozchikov, O., Perkin, J. D., Guerra, E. S. Pinzon, Plonski, P., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Quilain, B., Radicioni, E., Rato, P. N., Ravonel, M., Rayner, M. A., Reeves, M., Reinherz-Aronis, E., Retiere, F., Rodrigues, P. A., Rondio, E., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sacco, R., Sakashita, K., Sanchez, F., Scantamburlo, E., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shiozawa, M., Short, S., Shustrov, Y., Sinclair, P., Smith, B., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Southwell, L., Stamoulis, P., Steinmann, J., Still, B., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S. Y., Suzuki, Y., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Takahashi, S., Takeda, A., Takeuchi, Y., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Taylor, I. J., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Tobayama, S., Toki, W., Tomura, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Waldron, A. V., Walter, C. W., Wang, J., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wikstrom, G., Wilkes, R. J., Wilking, M. J., Wilkinson, C., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
High Energy Physics - Experiment
Abstract

The Tokai-to-Kamioka (T2K) experiment studies neutrino oscillations using an off-axis muon neutrino beam with a peak energy of about 0.6 GeV that originates at the J-PARC accelerator facility. Interactions of the neutrinos are observed at near detectors placed at 280 m from the production target and at the far detector -- Super-Kamiokande (SK) -- located 295 km away. The flux prediction is an essential part of the successful prediction of neutrino interaction rates at the T2K detectors and is an important input to T2K neutrino oscillation and cross section measurements. A FLUKA and GEANT3 based simulation models the physical processes involved in the neutrino production, from the interaction of primary beam protons in the T2K target, to the decay of hadrons and muons that produce neutrinos. The simulation uses proton beam monitor measurements as inputs. The modeling of hadronic interactions is re-weighted using thin target hadron production data, including recent charged pion and kaon measurements from the NA61/SHINE experiment. For the first T2K analyses the uncertainties on the flux prediction are evaluated to be below 15% near the flux peak. The uncertainty on the ratio of the flux predictions at the far and near detectors is less than 2% near the flux peak., Comment: 36 pages

Published
2012
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42. Indications for islet or pancreatic transplantation: Statement of the TREPID working group on behalf of the Société francophone du diabète (SFD), Société francaise d’endocrinologie (SFE), Société francophone de transplantation (SFT) and Société française de néphrologie – dialyse – transplantation (SFNDT)

Author

Andres, Axel, Armanet, Mathieu, Blancho, Gilles, Caillard, Sophie, Catargi, Bogdan, Cattan, Pierre, Lucy, Chailloux, Gabriel, Choukroun, Ciacio, Oriana, Cuellar, Emmanuel, Donatini, Gianluca, Duffas, Jean-Pierre, Durrbach, Antoine, Elias, Michelle, Frimat, Marie, Garrigue, Valérie, Gaudez, Francois, Hanaire, Hélène, Kamar, Nassim, Karam, Georges, Lablanche, Sandrine, Lejay, Anne, Le Mapihan, Kristell, Malvezzi, Paolo, Melki, Vincent, Moreau, Karine, Muscari, Fabrice, Ohlmann, Sophie, Panaro, Fabrizio, Peraldi, Marie-Noelle, Pittau, Gabriella, Prévost, Gaetan, Reffet, Sophie, Riveline, Jean-Pierre, Sacunha, Antonio, Serre, Jean-Emmanuel, Tetaz, Rachel, Thaunat, Olivier, Tillou, Xavier, Vidal-Trecan, Tiphaine, Wojtusciszyn, A., Branchereau, J., Esposito, L., Badet, L., Buron, F., Chetboun, M., Kessler, L., Morelon, E., Berney, T., Pattou, F., Benhamou, P.-Y., and Vantyghem, M.-C.

Published
2019
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44. Pion emission from the T2K replica target: method, results and application

Author

Abgrall, N., Aduszkiewicz, A., Anticic, T., Antoniou, N., Argyriades, J., Baatar, B., Blondel, A., Blumer, J., Bogomilov, M., Bravar, A., Brooks, W., Brzychczyk, J., Bubak, A., Bunyatov, S. A., Busygina, O., Christakoglou, P., Chung, P., Czopowicz, T., Davis, N., Debieux, S., Di Luise, S., Dominik, W., Dumarchez, J., Dynowski, K., Engel, R., Ereditato, A., Esposito, L. S., Feofilov, G. A., Fodor, Z., Ferrero, A., Fulop, A., Gazdzicki, M., Golubeva, M., Grabez, B., Grebieszkow, K., Grzeszczuk, A., Guber, F., Haesler, A., Hakobyan, H., Hasegawa, T., Idczak, R., Igolkin, S., Ivanov, Y., Ivashkin, A., Kadija, K., Kapoyannis, A., Katrynska, N., Kielczewska, D., Kikola, D., Kirejczyk, M., Kisiel, J., Kiss, T., Kleinfelder, S., Kobayashi, T., Kochebina, O., Kolesnikov, V. I., Kolev, D., Kondratiev, V. P., Korzenev, A., Kowalski, S., Krasnoperov, A., Kuleshov, S., Kurepin, A., Lacey, R., Larsen, D., Laszlo, A., Lyubushkin, V. V., Mackowiak-Pawlowska, M., Majka, Z., Maksiak, B., Malakhov, A. I., Maletic, D., Marchionni, A., Marcinek, A., Maris, I., Marin, V., Marton, K., Matulewicz, T., Matveev, V., Melkumov, G. L., Messina, M., Mrowczynski, St., Murphy, S., Nakadaira, T., Nishikawa, K., Palczewski, T., Palla, G., Panagiotou, A. D., Paul, T., Peryt, W., Petukhov, O., Planeta, R., Pluta, J., Popov, B. A., Posiadala, M., Pulawski, S., Puzovic, J., Rauch, W., Ravonel, M., Renfordt, R., Robert, A., Rohrich, D., Rondio, E., Rossi, B., Roth, M., Rubbia, A., Rustamov, A., Rybczynski, M., Sadovsky, A., Sakashita, K., Savic, M., Sekiguchi, T., Seyboth, P., Shibata, M., Sipos, R., Skrzypczak, E., Slodkowski, M., Staszel, P., Stefanek, G., Stepaniak, J., Strabel, C., Strobele, H., Susa, T., Szuba, M., Tada, M., Taranenko, A., Tereshchenko, V., Tolyhi, T., Tsenov, R., Turko, L., Ulrich, R., Unger, M., Vassiliou, M., Veberic, D., Vechernin, V. V., Vesztergombi, G., Wilczek, A., Wlodarczyk, Z., Wojtaszek-Szwarc, A., Wyszynski, O., Zambelli, L., Zipper, W., Galymov, V., Hartz, M., Ichikawa, A. K., Kubo, H., Marino, A. D., Matsuoka, K., Murakami, A., Nakaya, T., Suzuki, K., Yuan, T., and Zimmerman, E. D.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The T2K long-baseline neutrino oscillation experiment in Japan needs precise predictions of the initial neutrino flux. The highest precision can be reached based on detailed measurements of hadron emission from the same target as used by T2K exposed to a proton beam of the same kinetic energy of 30 GeV. The corresponding data were recorded in 2007-2010 by the NA61/SHINE experiment at the CERN SPS using a replica of the T2K graphite target. In this paper details of the experiment, data taking, data analysis method and results from the 2007 pilot run are presented. Furthermore, the application of the NA61/SHINE measurements to the predictions of the T2K initial neutrino flux is described and discussed., Comment: updated version as published by NIM A

Published
2012
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45. Performance of a 250L liquid Argon TPC for sub-GeV charged particle identification

Author

collaboration, J-PARC T32, Araoka, O., Badertscher, A., Curioni, A., Di Luise, S., Degunda, U., Epprecht, L., Esposito, L., Gendotti, A., Hasegawa, T., Horikawa, S., Kasami, K., Kimura, N., Knecht, L., Kobayashi, T., Lazzaro, C., Lussi, D., Maki, M., Marchionni, A., Maruyama, T., Meregaglia, A., Mitani, T., Nagasaka, Y., Naganoma, J., Naito, H., Narita, S., Natterer, G., Nguyen, K., Nishikawa, K., Okamoto, A., Okamoto, H., Petrolo, F., Resnati, F., Rossi, B., Rubbia, A., Strabel, C., Tanaka, M., Viant, T., Yamanoi, Y., Yorita, K., and Yoshioka, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We have constructed a liquid Argon TPC detector with fiducial mass of 150 kg as a part of the R&D program of the next generation neutrino and nucleon decay detector. This paper describes a study of particle identification performance of the detector using well-defined charged particles (pions, kaons, and protons) with momentum of ~800 MeV/$c$ obtained at J-PARC K1.1BR beamline., Comment: his paper has been withdrawn by the author due to a crucial problem on the result section

Published
2012

46. First Muon-Neutrino Disappearance Study with an Off-Axis Beam

Author

T2K Collaboration, Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calland, R., Calvet, D., Rodriguez, J. Caravaca, Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Duboyski, T., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M. A., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Hadley, D. R., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hiraki, T., Hirose, E., Holeczek, J., Horikawa, S., Huang, K., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laing, A., Laveder, M., Lawe, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Lister, C., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Naples, D., Navin, M. L., Nicholls, T. C., Nielsen, B., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Sinclair, P. D., Siyad, M., Smith, B. M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Veledar, O., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
High Energy Physics - Experiment
Abstract

We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment. With data corresponding to 1.43 10**20 protons on target, we observe 31 fully-contained single muon-like ring events in Super-Kamiokande, compared with an expectation of 104 +- 14 (syst) events without neutrino oscillations. The best-fit point for two-flavor nu_mu -> nu_tau oscillations is sin**2(2 theta_23) = 0.98 and |\Delta m**2_32| = 2.65 10**-3 eV**2. The boundary of the 90 % confidence region includes the points (sin**2(2 theta_23),|\Delta m**2_32|) = (1.0, 3.1 10**-3 eV**2), (0.84, 2.65 10**-3 eV**2) and (1.0, 2.2 10**-3 eV**2)., Comment: 7 pages, 4 figures

Published
2012
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47. Measurement of Production Properties of Positively Charged Kaons in Proton-Carbon Interactions at 31 GeV/c

Author

Collaboration, The NA61/SHINE, Abgrall, N., Aduszkiewicz, A., Anticic, T., Antoniou, N., Argyriades, J., Baatar, B., Blondel, A., Blumer, J., Bogusz, M., Boldizsar, L., Bravar, A., Brooks, W., Brzychczyk, J., Bubak, A., Bunyatov, S. A., Busygina, O., Cetner, T., Choi, K. -U., Christakoglou, P., Chung, P., Czopowicz, T., Davis, N., Diakonos, F., Di Luise, S., Dominik, W., Dumarchez, J., Engel, R., Ereditato, A., Esposito, L. S., Feofilov, G. A., Fodor, Z., Ferrero, A., Fulop, A., Garrido, X., Gazdzicki, M., Golubeva, M., Grebieszkow, K., Grzeszczuk, A., Guber, F., Haesler, A., Hakobyan, H., Hasegawa, T., Idczak, R., Ivanov, Y., Ivashkin, A., Kadija, K., Kapoyannis, A., Katrynska, N., Kielczewska, D., Kikola, D., Kim, J. -H., Kirejczyk, M., Kisiel, J., Kobayashi, T., Kochebina, O., Kolesnikov, V. I., Kolev, D., Kondratiev, V. P., Korzenev, A., Kowalski, S., Krasnoperov, A., Kuleshov, S., Kurepin, A., Lacey, R., Lagoda, J., Laszlo, A., Lyubushkin, V. V., Mackowiak-Pawlowska, M., Majka, Z., Malakhov, A. I., Marchionni, A., Marcinek, A., Maris, I., Marin, V., Matulewicz, T., Matveev, V., Melkumov, G. L., Meregaglia, A., Messina, M., Mrowczynski, St., Murphy, S., Nakadaira, T., Nishikawa, K., Palczewski, T., Palla, G., Panagiotou, A. D., Paul, T., Peryt, W., Petukhov, O., Planeta, R., Pluta, J., Popov, B. A., Posiadala, M., Pulawski, S., Rauch, W., Ravonel, M., Renfordt, R., Robert, A., Rohrich, D., Rondio, E., Rossi, B., Roth, M., Rubbia, A., Rybczynski, M., Sadovsky, A., Sakashita, K., Sekiguchi, T., Seyboth, P., Shibata, M., Skrzypczak, E., Slodkowski, M., Staszel, P., Stefanek, G., Stepaniak, J., Strabel, C., Strobele, H., Susa, T., Szaflik, P., Szuba, M., Tada, M., Taranenko, A., Tereshchenko, V., Tsenov, R., Turko, L., Ulrich, R., Unger, M., Vassiliou, M., Veberic, D., Vechernin, V. V., Vesztergombi, G., Wilczek, A., Wlodarczyk, Z., Wojtaszek-Szwarc, A., Yi, J. -G., Yoo, I. -K., Zambelli, L., and Zipper, W.

Subjects
High Energy Physics - Experiment
Abstract

Spectra of positively charged kaons in p+C interactions at 31 GeV/c were measured with the NA61/SHINE spectrometer at the CERN SPS. The analysis is based on the full set of data collected in 2007 with a graphite target with a thickness of 4% of a nuclear interaction length. Interaction cross sections and charged pion spectra were already measured using the same set of data. These new measurements in combination with the published ones are required to improve predictions of the neutrino flux for the T2K long baseline neutrino oscillation experiment in Japan. In particular, the knowledge of kaon production is crucial for precisely predicting the intrinsic electron neutrino component and the high energy tail of the T2K beam. The results are presented as a function of laboratory momentum in 2 intervals of the laboratory polar angle covering the range from 20 up to 240 mrad. The kaon spectra are compared with predictions of several hadron production models. Using the published pion results and the new kaon data, the K+/\pi+ ratios are computed., Comment: 10 pages, 11 figures

Published
2011
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48. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision., Comment: 32 pages, 27 figures, submitted to Nucl. Instr. and Meth. A

Published
2011
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49. Best constants in Poincar\'e inequalities for convex domains

Author

Esposito, L., Nitsch, C., and Trombetti, C.

Subjects
Mathematics - Analysis of PDEs, 26D10, 35J92
Abstract

We prove a Payne-Weinberger type inequality for the $p$-Laplacian Neumann eigenvalues ($p\ge 2$). The inequality provides the sharp upper bound on convex domains, in terms of the diameter alone, of the best constants in Poincar\'e inequality. The key point is the implementation of a refinement of the classical P\'olya-Szeg\"o inequality for the symmetric decreasing rearrangement which yields an optimal weighted Wirtinger inequality.

Published
2011

50. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam

Author

The OPERA Collaboration, Adam, T., Agafonova, N., Aleksandrov, A., Altinok, O., Sanchez, P. Alvarez, Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bertolin, A., Bozza, C., Brugiere, T., Brugnera, R., Brunet, F., Brunetti, G., Buontempo, S., Carlus, B., Cavanna, F., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Colosimo, G., Crespi, M., D'Ambrosio, N., De Lellis, G., De Serio, M., Declais, Y., Sanchez, P. del Amo, Di Capua, F., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Efthymiopoulos, I., Egorov, O., Ereditato, A., Esposito, L. S., Favier, J., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Giorgini, M., Giovannozzi, M., Girerd, C., Goldberg, J., Gollnitz, C., Golubkov, D., Goncharova, L., Gornushkin, Y., Grella, G., Grianti, F., Gschwendtner, E., Guerin, C., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Enikeev, R., Hierholzer, M., Hollnagel, A., Ieva, M., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Jones, M., Juget, F., Kamiscioglu, M., Kawada, J., Kim, S. H., Kimura, M., Kiritsis, E., Kitagawa, N., Klicek, B., Knuesel, J., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Mazzoni, A., Medinaceli, E., Meisel, F., Meregaglia, A., Migliozzi, P., Mikado, S., Missiaen, D., Monacelli, P., Morishima, K., Moser, U., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Nikitina, V., Nitti, F., Ogawa, S., Okateva, N., Olchevsky, A., Palamara, O., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Riguzzi, F., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryasny, V., Ryazhskaya, O., Sato, O., Sato, Y., Sahnoun, Z., Schembri, A., Schuler, J., Lavina, L. Scotto, Serrano, J., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S., Stipcevic, M., Strauss, T., Takahashi, S., Tenti, M., Terranova, F., Tezuka, I., Tioukov, V., Tolun, P., Tran, N. T., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. -L., Wilquet, G., Wonsak, B., Wurtz, J., Yakushev, V., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The OPERA neutrino experiment at the underground Gran Sasso Laboratory has measured the velocity of neutrinos from the CERN CNGS beam over a baseline of about 730 km. The measurement is based on data taken by OPERA in the years 2009, 2010 and 2011. Dedicated upgrades of the CNGS timing system and of the OPERA detector, as well as a high precision geodesy campaign for the measurement of the neutrino baseline, allowed reaching comparable systematic and statistical accuracies. An arrival time of CNGS muon neutrinos with respect to the one computed assuming the speed of light in vacuum of (6.5 +/- 7.4(stat.)((+8.3)(-8.0)sys.))ns was measured corresponding to a relative difference of the muon neutrino velocity with respect to the speed of light (v-c)/c =(2.7 +/-3.1(stat.)((+3.4)(-3.3)(sys.))x10^(-6). The above result, obtained by comparing the time distributions of neutrino interactions and of protons hitting the CNGS target in 10.5 microseconds long extractions, was confirmed by a test performed at the end of 2011 using a short bunch beam allowing to measure the neutrino time of flight at the single interaction level., Comment: 34 pages, 22 figures This version replaces all previous ones

Published
2011
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