318 results on '"Ear Auricle pathology"'
Search Results
2. Nodular mass-A case of auricular schwannoma.
- Author
-
Chuang WC, Ueng SH, Chuang WY, and Chan KC
- Subjects
- Humans, Diagnosis, Differential, Ear Auricle pathology, Male, Female, Adult, Medical Illustration, Neurilemmoma pathology, Neurilemmoma diagnosis, Neurilemmoma diagnostic imaging, Ear Neoplasms pathology
- Abstract
Schwannomas are benign tumors derived from the sheath of Schwann cells. Though it is common to see schwannomas in the head and neck region, auricular schwannomas are rare and only few cases have been reported. There are no distinguishing clinical findings or images; therefore, the histopathological diagnosis is mandatory. We describe a case of auricular schwannoma with clinical pictures and discuss the differential diagnoses according to histopathologic findings., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
3. Gouty tophi of the pinna.
- Author
-
Gurney M, Morris S, and Saw K
- Subjects
- Humans, Male, Ear Auricle pathology, Gout Suppressants therapeutic use, Middle Aged, Gout pathology, Gout diagnosis
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2024
- Full Text
- View/download PDF
4. Bilateral pyogranulomatous otitis externa with putative cartilage destruction in a dog: A severe case of auricular chondritis?
- Author
-
De Lucia M, Mendes C, and Bertolini G
- Subjects
- Animals, Dogs, Male, Cartilage Diseases veterinary, Cartilage Diseases pathology, Cartilage Diseases drug therapy, Ear Cartilage pathology, Prednisolone therapeutic use, Prednisolone administration & dosage, Ear Auricle pathology, Dog Diseases pathology, Dog Diseases drug therapy, Dog Diseases diagnosis, Otitis Externa veterinary, Otitis Externa pathology, Otitis Externa drug therapy, Otitis Externa microbiology
- Abstract
Auricular chondritis of unknown cause was suspected in a 10-year-old male Bolognese dog with a five-month history of painful bilateral nodular and ulcerative pyogranulomatous dermatitis of the pinnae with putative auricular cartilage destruction. Pain and lesions resolved with immunosuppressive doses of prednisolone, yet the condition resulted in deformity of both pinnae and external canals., (© 2024 ESVD and ACVD.)
- Published
- 2024
- Full Text
- View/download PDF
5. Fall Ohrmuschelplastik.
- Subjects
- Humans, Plastic Surgery Procedures methods, Male, Esthetics, Ear Auricle surgery, Ear Auricle pathology
- Abstract
Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Published
- 2024
- Full Text
- View/download PDF
6. Dermoscopy of nasal and auricular gouty tophi.
- Author
-
Santos BSD, Maciel MAP, and Valente NYS
- Subjects
- Humans, Male, Gout pathology, Gout diagnostic imaging, Middle Aged, Ear Auricle pathology, Dermoscopy
- Published
- 2024
- Full Text
- View/download PDF
7. Perichondritis of the auricle: bacterial or fungal? (A case series).
- Author
-
Hu M and Cheng Y
- Subjects
- Humans, Male, Female, Ear Cartilage microbiology, Adult, Antifungal Agents therapeutic use, Mycoses microbiology, Mycoses diagnosis, Ear Auricle microbiology, Ear Auricle pathology, High-Throughput Nucleotide Sequencing, Middle Aged, Cartilage Diseases microbiology
- Abstract
Background: Suppurative perichondritis of the auricle is a common disease that can easily cause malformations if it develops into an uncontrolled infection. In nearly half of the cases, otolaryngologists cannot identify the pathogens involved., Case Presentation: In the present work, we described two cases of pyogenic perichondritis, with negative on conventional culture. However, using metagenomic next-generation sequencing (mNGS), we detected fungal infections in the patients and after the patients were given anti-fungal treatment, the patients achieved a good prognosis., Conclusions: These cases highlighted the possibility that fungi might be the involved pathogens in patients who have had multiple negative bacterial cultures, and mNGS should be applied in these cases. mNGS could be used as a supplement to traditional culture methods., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
8. Dermoid cyst of the auricle.
- Author
-
Dina E, Martínez Arias À, and Blázquez Mañá CM
- Subjects
- Humans, Male, Female, Dermoid Cyst diagnosis, Dermoid Cyst pathology, Dermoid Cyst diagnostic imaging, Ear Auricle pathology, Ear Neoplasms pathology, Ear Neoplasms diagnosis
- Published
- 2024
- Full Text
- View/download PDF
9. [Bilateral ulcers of the auricle - unusual expression of a known clinical picture].
- Author
-
Kobus K, Künzel J, Weber F, Bohr C, and Andorfer K
- Subjects
- Female, Humans, Diagnosis, Differential, Skin Ulcer pathology, Skin Ulcer diagnosis, Skin Ulcer surgery, Adult, Ear Auricle pathology, Ear Auricle surgery
- Abstract
Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.
- Published
- 2024
- Full Text
- View/download PDF
10. Infiltrated and nodular pinna in lepromatous leprosy.
- Author
-
Vangala NN, Madke B, Kashikar Y, and Mahajan S
- Subjects
- Humans, Male, Ear Auricle pathology, Leprostatic Agents therapeutic use, Adult, Leprosy, Lepromatous diagnosis, Leprosy, Lepromatous pathology, Leprosy, Lepromatous drug therapy
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2024
- Full Text
- View/download PDF
11. Copper Wire Loops to Achieve Pressure and Occlusion for Prevention of Recurrence of Auricular Keloids.
- Author
-
Mehta N, Khan E, Kaur J, and Gupta S
- Subjects
- Humans, Copper, Ear, External surgery, Ear, External pathology, Recurrence, Keloid prevention & control, Keloid surgery, Keloid pathology, Ear Auricle surgery, Ear Auricle pathology
- Published
- 2024
- Full Text
- View/download PDF
12. Tissue-resident macrophages specifically express Lactotransferrin and Vegfc during ear pinna regeneration in spiny mice.
- Author
-
Simkin J, Aloysius A, Adam M, Safaee F, Donahue RR, Biswas S, Lakhani Z, Gensel JC, Thybert D, Potter S, and Seifert AW
- Subjects
- Animals, Lactoferrin, Macrophages pathology, Murinae physiology, Cicatrix pathology, Ear Auricle pathology
- Abstract
The details of how macrophages control different healing trajectories (regeneration vs. scar formation) remain poorly defined. Spiny mice (Acomys spp.) can regenerate external ear pinnae tissue, whereas lab mice (Mus musculus) form scar tissue in response to an identical injury. Here, we used this dual species system to dissect macrophage phenotypes between healing modes. We identified secreted factors from activated Acomys macrophages that induce a pro-regenerative phenotype in fibroblasts from both species. Transcriptional profiling of Acomys macrophages and subsequent in vitro tests identified VEGFC, PDGFA, and Lactotransferrin (LTF) as potential pro-regenerative modulators. Examining macrophages in vivo, we found that Acomys-resident macrophages secreted VEGFC and LTF, whereas Mus macrophages do not. Lastly, we demonstrate the requirement for VEGFC during regeneration and find that interrupting lymphangiogenesis delays blastema and new tissue formation. Together, our results demonstrate that cell-autonomous mechanisms govern how macrophages react to the same stimuli to differentially produce factors that facilitate regeneration., Competing Interests: Declaration of interests At the time of publication, D.T. is employed by Glakosmithkline (GSK)., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
13. Auricular leishmaniasis mimicking squamous cell carcinoma of the pinna.
- Author
-
Unar AA, Awan MO, Akhtar S, and Akram S
- Subjects
- Middle Aged, Humans, Male, Ear, External pathology, Face pathology, Leishmaniasis, Cutaneous diagnosis, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Ear Auricle pathology
- Abstract
Cutaneous leishmaniasis can occur on any exposed area of the body; however, the pinna is an exceptionally rare site for the disease. Caused by the parasite Leishmania , cutaneous leishmaniasis has a wide range of presentations and thus is very easy to misdiagnose or mistake for a neoplastic lesion. Here, we report the case of a middle-aged male patient presenting with a painful, ulcerated lesion on the left auricle initially suspected to be a malignancy with histopathology eventually revealing a diagnosis of auricular leishmaniasis. The patient received appropriate therapy and was found to be disease free at follow-up. These isolated lesions of the pinna often resemble neoplastic lesions and thus may escape diagnosis for months at a time, increasing patient stress as well as expenditure. In addition, prompt recognition may also help mitigate recurrence of the disease, making it worthwhile to include cutaneous leishmaniasis as part of the differential, especially in endemic areas., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
14. Nodular Fasciitis in the Cavity of Auricular Concha: A Case Report.
- Author
-
Liu X and Li X
- Subjects
- Humans, Child, Infant, Diagnostic Errors, Diagnosis, Differential, Ear Auricle pathology, Fasciitis diagnosis, Fasciitis surgery, Fasciitis pathology
- Abstract
Nodular fasciitis (NF) has a low incidence, many classification subtypes and large histological variations. We describe a 17-month-old child who presented with a mass in the right cavity of auricular concha that was successfully cured by 2 procedures. In pediatric patients with fibroproliferative lesions, the possibility of NF should be excluded to avoid misdiagnosis and overtreatment.
- Published
- 2023
- Full Text
- View/download PDF
15. A successful reconstruction of the upper antihelix defect via postauricular pull-through pedicle flap.
- Author
-
Maciulaitis T, Venciute-Stankevice R, and Jakutis N
- Subjects
- Humans, Surgical Flaps, Ear, External pathology, Ear, External surgery, Plastic Surgery Procedures, Ear Auricle pathology, Ear Auricle surgery, Skin Neoplasms pathology, Skin Neoplasms surgery
- Abstract
The auricle is a complex anatomic structure with a three-dimensional configuration proper reinstating that poses a substantial reconstructive challenge. The postauricular pull-through flap is perfectly suitable method for the reconstruction of helical and antihelical auricle defects; however, due to its difficult harvest technique, it is not commonly used in a practice. Here we describe a case of a patient with an antihelix defect following basal cell carcinoma (BCC). In our case, the reconstruction was performed via postauricular pull-through pedicle flap, and a satisfactory result was achieved., Competing Interests: None
- Published
- 2022
- Full Text
- View/download PDF
16. An Algorithmic Approach for the Reconstruction of Extended Upper-Third Auricular Soft Tissue Defects.
- Author
-
Seretis K, Bounas N, and Lykoudis EG
- Subjects
- Esthetics, Dental, Humans, Surgical Flaps surgery, Ear Auricle pathology, Ear Auricle surgery, Plastic Surgery Procedures methods, Skin Neoplasms pathology, Skin Neoplasms surgery
- Abstract
Abstract: Auricular defects are demanding to reconstruct due to the complex anatomy and the three-dimensional shape of the ear. The functional perspective needs to be addressed without neglecting aesthetic outcomes though, given that it is a prominent facial landmark. In this report the reconstruction of a sizable soft tissue defect of the helical crus and upper third of the right auricle, following surgical excision of a skin tumor, is presented. A variety of treatment options is explored, and a relevant algorithm is proposed. This defect was reconstructed using a transposition flap from the postauricular area, accomplishing single-stage full defect coverage combined with optimal postoperative aesthetic results. High patient satisfaction levels were achieved, avoiding more complicated and prolonged procedures. This case exemplifies the proposed algorithmic approach of upper-third auricular defects, addressing these defects in a systematic and logical manner., Competing Interests: The authors report no conflicts of interest., (Copyright © 2021 by Mutaz B. Habal, MD.)
- Published
- 2022
- Full Text
- View/download PDF
17. Keloid of earlobe treated with a combination of pneumatic injector device and CO 2 fractional laser.
- Author
-
Park JW, Shin SH, Koh YG, Seok J, Choi SY, Li K, Kim BJ, and Yoo KH
- Subjects
- Carbon Dioxide, Humans, Injections, Treatment Outcome, Ear Auricle pathology, Keloid pathology, Keloid radiotherapy, Lasers, Gas therapeutic use
- Published
- 2022
- Full Text
- View/download PDF
18. A new combined surgical and medical technique for auricular keloids.
- Author
-
Román-Sainz J, Romero-Jiménez B, Gruber-Velasco F, Silvestre-Torner N, and Imbernón-Moya A
- Subjects
- Combined Modality Therapy, Humans, Recurrence, Ear Auricle pathology, Ear Auricle surgery, Keloid pathology, Keloid surgery
- Published
- 2022
- Full Text
- View/download PDF
19. [Unilateral auricle twitching with refractory neuralgic pain after a tympanotomy].
- Author
-
Ziadat R, Volk GF, Thielker J, and Guntinas-Lichius O
- Subjects
- Humans, Ear Auricle pathology, Middle Ear Ventilation adverse effects, Neuralgia etiology
- Abstract
Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.
- Published
- 2022
- Full Text
- View/download PDF
20. Unilateral, painless auricular papules.
- Author
-
Elamin S, McCourt C, and Houghton J
- Subjects
- Diagnosis, Differential, Ear Diseases pathology, Granuloma Annulare pathology, Humans, Male, Young Adult, Ear Auricle pathology, Ear Diseases diagnosis, Granuloma Annulare diagnosis
- Published
- 2021
- Full Text
- View/download PDF
21. Lasting response after discontinuation of cemiplimab in a patient with locally advanced basal cell carcinoma.
- Author
-
De Giorgi V, Trane L, Savarese I, Silvestri F, Venturi F, Zuccaro B, and Scarfì F
- Subjects
- Aged, Carcinoma, Basal Cell pathology, Ear Auricle pathology, Ear Neoplasms pathology, Humans, Male, Skin pathology, Skin Neoplasms pathology, Antibodies, Monoclonal, Humanized therapeutic use, Carcinoma, Basal Cell drug therapy, Ear Neoplasms drug therapy, Immune Checkpoint Inhibitors therapeutic use, Skin Neoplasms drug therapy
- Published
- 2021
- Full Text
- View/download PDF
22. Firm Nodule on the Ear.
- Author
-
Helm M, Ng B, and Mogavero A
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Biopsy methods, Diagnosis, Differential, Gout Suppressants therapeutic use, Humans, Male, Uric Acid isolation & purification, Ear Auricle pathology, Gout diagnosis, Gout pathology, Gout therapy, Skin Diseases, Papulosquamous diagnosis, Skin Diseases, Papulosquamous pathology, Skin Neoplasms diagnosis
- Published
- 2021
23. Pressure therapy with a novel compressive device for auricular keloids treatment after surgical excision.
- Author
-
Sun M, Wang Y, Xue C, and Zhu J
- Subjects
- Adult, Aged, Combined Modality Therapy methods, Equipment Design, Female, Humans, Pressure, Plastic Surgery Procedures methods, Secondary Prevention, Treatment Outcome, Ear Auricle pathology, Ear Auricle surgery, Ear Deformities, Acquired etiology, Ear Deformities, Acquired therapy, Keloid etiology, Keloid prevention & control, Keloid therapy, Postoperative Complications etiology, Postoperative Complications therapy, Plastic Surgery Procedures adverse effects, Therapy, Soft Tissue instrumentation, Therapy, Soft Tissue methods
- Published
- 2021
- Full Text
- View/download PDF
24. A longitudinal study of changes of congenital auricular deformity regarding self-correction.
- Author
-
Kim M, Lee HM, Choi SW, Lee S, Kim C, Kong SK, Lee IW, and Oh SJ
- Subjects
- Ear Auricle diagnostic imaging, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Remission, Spontaneous, Sex Factors, Congenital Abnormalities pathology, Ear Auricle abnormalities, Ear Auricle pathology
- Abstract
This study aimed to investigate the factors associated with congenital auricular deformities and evaluate the long-term frequency of their self-correction. Ninety newborns were enrolled in the study, and data were collected within 2 weeks after birth and at 1 year. The shape of the auricle was classified into seven categories using a digital image. At 2 weeks after birth, several birth-related factors were evaluated in the auricular deformity and normal groups. At 1 year after birth, the images of auricles were compared with the images at birth, and the changes in the auricle shape were investigated. Congenital auricular deformities were observed in 139 out of 180 ears, and the major type noted was helix rim deformity (47 ears), followed by normal ears (41 ears), and cup ears (33 ears). Male sex was found to have a statistically significant association with the occurrence of auricular deformity. In the longitudinal study, among 43 neonates (86 ears) followed-up 12 months later, the self-correction rate was approximately 50%. The normal auricle and prominent ear increased, helix rim deformity and cup ear decreased significantly. The prognosis of deformity varied depending on the type of deformity. Considering the low self-correction rate in the prominent and cup ears, newborns with these deformities might be recommended to undergo management such as auricle molding technique, as required., (Copyright © 2021 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
25. Bilateral Earlobe Necrosis Due to External Application of Calcium Hydroxide.
- Author
-
Pawar M
- Subjects
- Adult, Female, Humans, Necrosis, Bone Cements adverse effects, Calcium Hydroxide adverse effects, Dermatitis, Irritant etiology, Dermatitis, Irritant pathology, Ear Auricle pathology
- Abstract
Competing Interests: The author has no funding or conflicts of interest to declare.
- Published
- 2021
- Full Text
- View/download PDF
26. Psoriasiform rashes as the first manifestation of anti-MDA5 associated myositis.
- Author
-
Rathore U, Haldule S, and Gupta L
- Subjects
- Arthritis immunology, Arthritis physiopathology, Dermatomyositis immunology, Dermatomyositis physiopathology, Exanthema pathology, Fever physiopathology, Humans, Male, Muscle Weakness immunology, Muscle Weakness physiopathology, Myositis immunology, Myositis pathology, Myositis physiopathology, Young Adult, Autoantibodies immunology, Dermatomyositis pathology, Ear Auricle pathology, Facial Dermatoses pathology, Interferon-Induced Helicase, IFIH1 immunology, Scalp Dermatoses pathology
- Published
- 2021
- Full Text
- View/download PDF
27. Variability of Sarcoid Skin Manifestations Is Illustrated in a Patient With Multiple Concurrent Pinna Lesions.
- Author
-
Jones SE and Pollak N
- Subjects
- Humans, Male, Medical Illustration, Middle Aged, Ear Auricle pathology, Ear Diseases pathology, Sarcoidosis pathology, Skin Diseases pathology
- Published
- 2021
- Full Text
- View/download PDF
28. Repair of Large Chondrocutaneous Helical Defect.
- Author
-
Myers K, Howerter S, Fancher W, and Lear W
- Subjects
- Aged, 80 and over, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell surgery, Cartilage transplantation, Ear Auricle pathology, Ear Neoplasms pathology, Ear Neoplasms surgery, Esthetics, Humans, Male, Skin Neoplasms pathology, Skin Neoplasms surgery, Surgical Wound etiology, Suture Techniques, Treatment Outcome, Ear Auricle surgery, Mohs Surgery adverse effects, Surgical Flaps transplantation, Surgical Wound surgery
- Published
- 2021
- Full Text
- View/download PDF
29. Dermatofibrosarcoma Protuberans With Perineural Invasion of the Neck Treated With Mohs Micrographic Surgery.
- Author
-
Pride RLD, Wieland CN, and Vidal NY
- Subjects
- Biopsy, Dermatofibrosarcoma diagnosis, Dermatofibrosarcoma pathology, Ear Auricle innervation, Ear Auricle pathology, Ear Auricle surgery, Humans, Male, Middle Aged, Neck innervation, Neck pathology, Neck surgery, Neoplasm Invasiveness diagnosis, Neoplasm Invasiveness pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Treatment Outcome, Dermatofibrosarcoma surgery, Mohs Surgery, Peripheral Nerves pathology, Skin Neoplasms surgery
- Published
- 2021
- Full Text
- View/download PDF
30. The Relationship Between Earlobe Creases and the Presence, Extent, and Severity of Coronary Artery Atherosclerosis: A Regional Population-Based Autopsy Study.
- Author
-
French CEV, Rutherford JD, Goossens L, and Tiemensma M
- Subjects
- Adult, Aged, Aged, 80 and over, Body Mass Index, Case-Control Studies, Coronary Vessels pathology, Female, Forensic Pathology, Humans, Male, Middle Aged, Plaque, Atherosclerotic pathology, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Young Adult, Coronary Artery Disease diagnosis, Ear Auricle pathology, Severity of Illness Index
- Abstract
Abstract: The association between earlobe crease(s) and coronary artery atherosclerosis has stimulated debate and controversy over the years. Most available published studies have been conducted on living patients. Although these studies offer valuable insight into such associations in patients who exhibit symptoms, no information is available from these studies on the prevalence of earlobe creases among an asymptomatic population. Postmortem studies offer the advantage of including individuals free of symptomatic cardiovascular disease, thus providing an inbuilt control group. The atherosclerotic pathological findings of 1298 individuals who underwent coronial postmortem examination at Wellington Regional Hospital, New Zealand, between 2006 and 2013 were retrospectively studied. Earlobe creases and atherosclerosis involving the coronary arteries were semiquantitatively appraised. The presence of an earlobe crease was found to be significantly associated with coronary artery atherosclerosis., Competing Interests: The authors report no conflict of interest., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
31. Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications.
- Author
-
Chang B, Cornett A, Nourmohammadi Z, Law J, Weld B, Crotts SJ, Hollister SJ, Lombaert IMA, and Zopf DA
- Subjects
- Animals, Biopsy, Child, Chondrogenesis, Computer-Aided Design, Costal Cartilage transplantation, Disease Models, Animal, Ear Auricle anatomy & histology, Ear Auricle pathology, Ear Auricle surgery, Ear Cartilage anatomy & histology, Ear Cartilage diagnostic imaging, Ear Cartilage pathology, Humans, Male, Photography, Polyesters, Prospective Studies, Rats, Plastic Surgery Procedures instrumentation, Plastic Surgery Procedures methods, Surgical Wound Infection etiology, Surgical Wound Infection pathology, Surgical Wound Infection prevention & control, Tomography, X-Ray Computed, Transplantation, Autologous adverse effects, Transplantation, Autologous instrumentation, Treatment Outcome, Ear Auricle diagnostic imaging, Ear Cartilage surgery, Printing, Three-Dimensional, Plastic Surgery Procedures adverse effects, Surgical Wound Infection epidemiology, Tissue Scaffolds
- Abstract
Objectives/hypothesis: To analyze the use of highly translatable three-dimensional (3D)-printed auricular scaffolds with and without novel cartilage tissue inserts in a rodent model., Study Design: Preclinical rodent animal model., Methods: This prospective study assessed a single-stage 3D-printed auricular bioscaffold with or without porcine cartilage tissue inserts in an athymic rodent model. Digital Imaging and Communications in Medicine computed tomography images of a human auricle were segmented to create an external anatomic envelope filled with orthogonally interconnected spherical pores. Scaffolds with and without tissue inset sites were 3D printed by laser sintering bioresorbable polycaprolactone, then implanted subcutaneously in five rats for each group., Results: Ten athymic rats were studied to a goal of 24 weeks postoperatively. Precise anatomic similarity and scaffold integrity were maintained in both scaffold conditions throughout experimentation with grossly visible tissue ingrowth and angiogenesis upon explantation. Cartilage-seeded scaffolds had relatively lower rates of nonsurgical site complications compared to unseeded scaffolds with relatively increased surgical site ulceration, though neither met statistical significance. Histology revealed robust soft tissue infiltration and vascularization in both seeded and unseeded scaffolds, and demonstrated impressive maintenance of viable cartilage in cartilage-seeded scaffolds. Radiology confirmed soft tissue infiltration in all scaffolds, and biomechanical modeling suggested amelioration of stress in scaffolds implanted with cartilage., Conclusions: A hybrid approach incorporating cartilage insets into 3D-printed bioscaffolds suggests enhanced clinical and histological outcomes. These data demonstrate the potential to integrate point-of-care tissue engineering techniques into 3D printing to generate alternatives to current reconstructive surgery techniques and avoid the demands of traditional tissue engineering., Level of Evidence: NA Laryngoscope, 131:1008-1015, 2021., (© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).)
- Published
- 2021
- Full Text
- View/download PDF
32. Tracing the Origins of "Cauliflower Ear" and Its Earlier Names over Two Millenia.
- Author
-
Mudry A and Jackler RK
- Subjects
- Ear Auricle blood supply, Ear Auricle pathology, Ear Deformities, Acquired diagnosis, Ear Deformities, Acquired history, Ear Deformities, Acquired pathology, Ear Diseases etiology, Ear Diseases history, Ear Diseases pathology, Hematoma complications, History, 18th Century, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval, Humans, Sports trends, Terminology as Topic, Athletic Injuries complications, Ear Auricle abnormalities, Ear Auricle injuries, Ear Deformities, Acquired etiology
- Abstract
Objectives: The post-traumatic ear deformity, known today as cauliflower ear, has been described since antiquity. It has long been associated with pugilistic sports (wrestling, boxing) as well as among the mentally ill. The aim of this study is to present the various terms used since antiquity to describe these traumatic deformations of the auricle and to trace the origin of the modern moniker "cauliflower ear.", Methods: Historical study, only based on original documentation accessed through personal libraries and universities repositories, completed with online sources and etymological dictionaries., Results: We were able to identify no fewer than 39 names for the deformity. The term cauliflower ear is of relatively recent origin. It was coined in the first decade of the 20th century, initially in the popular press and subsequently adopted by the medical profession., Conclusion: Ironically, the deformity has only superficial resemblance to a cauliflower. The vegetable, which is part of the cabbage family, has a symmetrical and highly ordered fractal geometry with well-circumscribed excrescences. Cauliflower ear, by contrast, notably lacks symmetry and its rounded protuberances flow into one another. Although somewhat a misnomer, the term is deeply rooted in both popular and medical culture., Level of Evidence: N/A Laryngoscope, 131:E1315-E1321, 2021., (© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).)
- Published
- 2021
- Full Text
- View/download PDF
33. Bone wax as an ideal dressing for auricle concha.
- Author
-
Perandones-González H, Fernández-Canga P, and Rodríguez-Prieto MÁ
- Subjects
- Administration, Topical, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell surgery, Ear Auricle blood supply, Ear Auricle pathology, Ear Neoplasms pathology, Ear Neoplasms surgery, Humans, Postoperative Hemorrhage etiology, Skin Neoplasms pathology, Skin Neoplasms surgery, Treatment Outcome, Waxes, Ear Auricle surgery, Hemostatic Techniques, Mohs Surgery adverse effects, Palmitates administration & dosage, Postoperative Hemorrhage therapy
- Published
- 2021
- Full Text
- View/download PDF
34. Is Kimura's disease associated with juvenile temporal arteritis? A case report and literature review of all juvenile temporal arteritis cases.
- Author
-
Tomizuka T, Kikuchi H, Asako K, Tsukui D, Kimura Y, Kikuchi Y, Sasajima Y, and Kono H
- Subjects
- Adult, Asian People, Giant Cell Arteritis complications, Humans, Kimura Disease complications, Male, Ear Auricle pathology, Giant Cell Arteritis pathology, Kimura Disease pathology, Temporal Arteries pathology
- Abstract
Both juvenile temporal arteritis (JTA) and Kimura's disease are eosinophilic inflammatory conditions but exhibit different clinical manifestations. Here, we describe a case involving a 40-year-old man who developed JTA secondary to Kimura's disease. Approximately 3 years before admission, masses appeared on both posterior auricles. A biopsy of the right posterior auricle mass led to a diagnosis of Kimura's disease. Approximately 4 months before admission, both masses increased in size, and almost simultaneously, the left temporal artery became distended. Histopathology of a biopsy of the left temporal artery revealed inflammatory findings with marked eosinophil infiltration and significant intimal hyperplasia with stenosis of the vascular lumen, indicating JTA. An analysis of the 48 reported cases of JTA, identified in a literature review, and the present case, revealed that Kimura's disease was detected in 6 cases, all of which involved Asians. In conclusion, this case and the literature review suggest that JTA can be accompanied by another eosinophilic inflammation-based disorder, Kimura's disease, particularly in Asians. This newly highlighted relationship between JTA and Kimura's disease could lead to a better understanding of JTA, which is an extremely rare disease.
- Published
- 2021
- Full Text
- View/download PDF
35. Biofilm-coated microbeads and the mouse ear skin: An innovative model for analysing anti-biofilm immune response in vivo.
- Author
-
Sauvat L, Abdul Hamid AI, Blavignac C, Josse J, Lesens O, and Gueirard P
- Subjects
- Animals, Cell Movement, Disease Models, Animal, Ear Auricle immunology, Ear Auricle microbiology, Female, Fluorescent Dyes chemistry, Immunity, Innate, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Microspheres, Phagocytes cytology, Phagocytes immunology, Silicon Dioxide chemistry, Staphylococcal Infections pathology, Time-Lapse Imaging, Biofilms growth & development, Ear Auricle pathology, Phagocytes pathology, Staphylococcal Infections immunology, Staphylococcus aureus pathogenicity
- Abstract
Owing to its ability to form biofilms, Staphylococcus aureus is responsible for an increasing number of infections on implantable medical devices. The aim of this study was to develop a mouse model using microbeads coated with S. aureus biofilm to simulate such infections and to analyse the dynamics of anti-biofilm inflammatory responses by intravital imaging. Scanning electron microscopy and flow cytometry were used in vitro to study the ability of an mCherry fluorescent strain of S. aureus to coat silica microbeads. Biofilm-coated microbeads were then inoculated intradermally into the ear tissue of LysM-EGFP transgenic mice (EGFP fluorescent immune cells). General and specific real-time inflammatory responses were studied in ear tissue by confocal microscopy at early (4-6h) and late time points (after 24h) after injection. The displacement properties of immune cells were analysed. The responses were compared with those obtained in control mice injected with only microbeads. In vitro, our protocol was capable of generating reproducible inocula of biofilm-coated microbeads verified by labelling matrix components, observing biofilm ultrastructure and confirmed in vivo and in situ with a matrix specific fluorescent probe. In vivo, a major inflammatory response was observed in the mouse ear pinna at both time points. Real-time observations of cell recruitment at injection sites showed that immune cells had difficulty in accessing biofilm bacteria and highlighted areas of direct interaction. The average speed of cells was lower in infected mice compared to control mice and in tissue areas where direct contact between immune cells and bacteria was observed, the average cell velocity and linearity were decreased in comparison to cells in areas where no bacteria were visible. This model provides an innovative way to analyse specific immune responses against biofilm infections on medical devices. It paves the way for live evaluation of the effectiveness of immunomodulatory therapies combined with antibiotics., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
- Full Text
- View/download PDF
36. Single-Sling Island Pedicle Flap With Bilevel Undermining for Repair of Superior Helical Rim Defects.
- Author
-
Alniemi DT, DeWitt C, Goldman GD, and Holmes TE
- Subjects
- Aged, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Ear Auricle pathology, Ear Neoplasms pathology, Ear Neoplasms surgery, Humans, Male, Surgical Wound etiology, Ear Auricle surgery, Mohs Surgery adverse effects, Plastic Surgery Procedures methods, Surgical Flaps transplantation, Surgical Wound surgery
- Published
- 2020
- Full Text
- View/download PDF
37. Complete response with talimogene laherparepvec in recurrent melanoma of the ear: A case report.
- Author
-
Hsu AC, Kokot NC, Eisenberg BL, and Thomas JS
- Subjects
- Adult, Ear Neoplasms pathology, Ear Neoplasms surgery, Herpesvirus 1, Human, Humans, Injections, Intralesional, Male, Melanoma pathology, Melanoma surgery, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local surgery, Antineoplastic Agents, Immunological administration & dosage, Biological Products administration & dosage, Ear Auricle pathology, Ear Neoplasms drug therapy, Melanoma drug therapy, Neoplasm Recurrence, Local drug therapy
- Abstract
The current standard of care for cutaneous melanoma of the ear is surgical excision. This approach may result in unfavorable functional and cosmetic outcomes. We report here a case of recurrent melanoma of the ear that achieved complete response with talimogene laherparepvec treatment after the patient declined surgical resection., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
38. On-site cytological diagnosis of cylindroma: A case report.
- Author
-
Tummidi S and Nagiredla P
- Subjects
- Aged, Cytodiagnosis methods, Ear Auricle pathology, Female, Humans, Salivary Gland Neoplasms diagnosis, Salivary Gland Neoplasms pathology, Carcinoma, Adenoid Cystic diagnosis, Carcinoma, Adenoid Cystic pathology, Neoplasms, Adnexal and Skin Appendage diagnosis, Neoplasms, Adnexal and Skin Appendage pathology
- Abstract
A 70-year-old female presented with a swelling in the right auricle for 6 months. Rapid onsite stain and routine cytology revealed clusters of small, round to oval cells with hyperchromatic nuclei, inconspicuous nucleoli, and scant cytoplasm. The background had basement membrane type material and appeared dark magenta colored pinkish globular material. Hence a cytological diagnosis of skin adnexal tumor possibly cylindroma was made. The excision of the lesion also showed features of cylindroma. Rapid onsite staining and cytology of subcutaneous location of the tumor in the absence of primary salivary gland tumors may help to diagnose such rare cases., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
- Full Text
- View/download PDF
39. Repair of a Deep Auricular Wound.
- Author
-
Potter KA, Charos AE, and Chen DL
- Subjects
- Aged, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell surgery, Ear Auricle pathology, Ear Cartilage transplantation, Ear Neoplasms pathology, Ear Neoplasms surgery, Esthetics, Humans, Male, Surgical Flaps transplantation, Surgical Wound etiology, Treatment Outcome, Ear Auricle surgery, Mohs Surgery adverse effects, Plastic Surgery Procedures methods, Surgical Wound surgery
- Published
- 2020
- Full Text
- View/download PDF
40. Auricle perniosis as a manifestation of Covid-19 infection.
- Author
-
Proietti I, Tolino E, Bernardini N, Mambrin A, Balduzzi V, Marchesiello A, Michelini S, Del Borgo C, Skroza N, Lichtner M, and Potenza C
- Subjects
- Adult, Chilblains pathology, Ear Auricle pathology, Female, Humans, COVID-19 complications, Chilblains etiology, SARS-CoV-2
- Published
- 2020
- Full Text
- View/download PDF
41. Dermoid Cyst in the Postauricular Area.
- Author
-
Jeong J, Choi YJ, Lee K, and Choi HS
- Subjects
- Adult, Dermoid Cyst diagnostic imaging, Ear Auricle pathology, Ear Neoplasms diagnostic imaging, Ear Neoplasms pathology, Female, Humans, Dermoid Cyst surgery, Ear Neoplasms surgery
- Abstract
Dermoid cyst is a rare benign tumor and about 7% of occurrences are found in the head and neck region. Its location is almost always in the midline of the body such as the orbit, oral cavity, and nose, but it is rarer in and around the auricle. The authors present a 31-year-old woman with dermoid cyst in the postauricular area which is a rare site for this lesion. In surgery under local anesthesia, the mass was limited to the subcutaneous area and excised completely. Surgical excision should be considered for cosmetic reasons and the mass should be excised completely to prevent recurrence and infection. Histopathologic confirmation is important and mandatory after excision to confirm the pathologic diagnosis and rule out the possibility of malignancy.
- Published
- 2020
- Full Text
- View/download PDF
42. Postauricular Island Flap in Reconstruction of Auricula Tumor Defects.
- Author
-
Mehel DM, Özdemir D, Çelebi M, Saraç N, Aydemir S, and Özgür A
- Subjects
- Aged, Aged, 80 and over, Carcinoma, Basal Cell surgery, Carcinoma, Basosquamous surgery, Carcinoma, Squamous Cell surgery, Ear Auricle pathology, Female, Humans, Male, Middle Aged, Plastic Surgery Procedures methods, Ear Auricle surgery, Surgical Flaps surgery
- Abstract
The most common malignant tumor in humans is skin cancers. Skin cancers are most commonly seen in the head and neck region due to direct exposure to sunlight. Most frequently seen skin cancer in the auricula are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The aim of this study is to evaluate the results of postauricular island flap after resection of tumors in the auricula.Twelve patients aged 58 to 84 years were included in the study. Eight patients had BCC, 3 had SCC, and 1 had basosquamous carcinoma (BSC). The tumor was located at the cavum concha in 7 cases, antihelix in 3 cases, triangular fossa in 1 case and scapha in 1 case. Surgical procedure was performed under local anesthesia in 7 patients and under general anesthesia in 5 patients. Postauricular island flap was used in all cases. There were no early complications. Three patients had non-apparent narrowing of the auriculomastoid angle. The patients were followed for an average of 2.6 years between 1 and 9 years. Only one patient with basosquamous carcinoma of the cavum concha had recurrence at 19 months.We believe that the postauricular island flap may be a good alternative for the reconstruction of the defect after resection of tumors in the auricle due to its proximity to the surgical site, color matching, adequate thickness, good vascularization, aesthetic acceptance by the patient and completion of the procedure in one session.
- Published
- 2020
- Full Text
- View/download PDF
43. Progression of aural plaques to squamous cell carcinoma in a horse.
- Author
-
Peters-Kennedy J, Lange CE, and Ortved K
- Subjects
- Animals, Carcinoma, Squamous Cell pathology, Horse Diseases virology, Horses, Male, Papillomavirus Infections pathology, Papillomavirus Infections virology, Skin Diseases, Viral pathology, Skin Diseases, Viral virology, Skin Neoplasms pathology, Skin Neoplasms virology, Carcinoma, Squamous Cell veterinary, Ear Auricle pathology, Horse Diseases pathology, Papillomavirus Infections veterinary, Skin Diseases, Viral veterinary, Skin Neoplasms veterinary
- Abstract
Background: Aural plaques are associated with and thought to be caused by one or more Equus caballus papillomaviruses (EcPV). Aural plaques have not previously been reported to be associated with squamous cell carcinoma (SCC)., Hypothesis/objectives: To describe a horse with aural plaques and squamous cell carcinoma (SCC) on the right pinna., Animals: A 28-year-old thoroughbred gelding presented for multiple plaques and a mass on the right pinna., Methods and Materials: Pinnal resection, histopathological investigation, multiple conventional PCRs for papillomavirus DNA and Sanger sequencing were performed., Results: Multiple, raised, pale tan, fronded plaques covered 60% of the concave surface of the right pinna. Focally these plaques coalesced into an exophytic ulcerated mass near the base of the pinna. Multiple aural plaques and a SCC were diagnosed histopathologically. EcPV4 was detected via PCR in a sample of the SCC., Conclusions and Clinical Importance: This report demonstrates the possibility of malignant transformation from aural plaques to SCC on the pinna of a horse. To the best of the authors' knowledge, this is the first report of EcPV4 associated with SCC., (© 2020 the European Society of Veterinary Dermatology and the American College of Veterinary Dermatology.)
- Published
- 2020
- Full Text
- View/download PDF
44. Reconstruction of Cutaneous Defects of the Ear Using the Post-Auricular Reservoir: A Systematic Review.
- Author
-
Worley B and Cohen JL
- Subjects
- Ear Auricle pathology, Ear Auricle surgery, Ear Neoplasms pathology, Esthetics, Humans, Skin Neoplasms pathology, Surgical Wound etiology, Treatment Outcome, Ear Neoplasms surgery, Plastic Surgery Procedures methods, Skin Neoplasms surgery, Surgical Flaps transplantation, Surgical Wound surgery
- Abstract
Background: An approach to the reconstruction of the ear requires consideration of gross anatomy, blood supply, and size of the defect to select the repair. While skin grafts provide a convenient option for many helical and conchal defects, using posterior auricular reservoir can preserve ear contour and hide the scar for an aesthetic closure., Purpose: To illustrate the versatility of the post-auricular and mastoid skin reservoir for auricular repairs after surgical removal of a cutaneous malignancy., Data Sources: MEDLINE, EMBASE, and Cochrane Databases were searched for all techniques using a post-auricular approach for auricular repair of surgical defects in the context of cutaneous oncology until November 2019., Data Synthesis: The most well-described techniques of pull-through, post-auricular pedicle and Banner flaps were selected for in-depth review. Illustrative cases and a summary of the spectrum of techniques from case reports are provided., Limitations: Few randomized trials exist to compare the outcomes of the flaps to determine a preferred flap technique., Conclusions: A post-auricular approach for repair of auricular defects can provide a reasonable option for single and multi-staged closure to create an excellent aesthetic outcome while hiding the donor site. More prospective data is required to determine the overall best approach. J Drugs Dermatol. 2020;19(9):883-888. doi:10.36849/JDD.2020.5106.
- Published
- 2020
- Full Text
- View/download PDF
45. Recurrent angiolymphoid hyperplasia with eosinophilia during several pregnancies.
- Author
-
Cenk H, Kapicioglu Y, Sarac G, Sener S, and Sahin N
- Subjects
- Adult, Angiolymphoid Hyperplasia with Eosinophilia surgery, Biopsy, Ear Auricle surgery, Ear Diseases pathology, Ear Diseases surgery, Female, Humans, Pregnancy, Recurrence, Angiolymphoid Hyperplasia with Eosinophilia pathology, Ear Auricle pathology, Laser Therapy, Pregnancy Complications pathology
- Abstract
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular tumor. Although its etiology is not clearly known, infection, hormonal factors, and trauma are the suspected reasons. There are few cases considered to be related to pregnancy described in the literature. Granulomas are rarely seen in the histopathology and only four patients with granulomas have been described. Herein, we will present a 28-year-old woman who has been pregnant three times; in every pregnancy, she developed pink nodular lesions on the back of her ear. In the first two pregnancies, the lesions had appeared during the pregnancy and regressed completely in the postpartum period. In her third pregnancy, the condition emerged again and lasted 1.5 years after birth of her child. Histopathology exhibited ALHE with granulomas. Although the relationship between ALHE and pregnancy is already known, there are few cutaneous ALHE cases associated with pregnancy reported in the literature. This association is further supported by this case having recurrent ALHE during each pregnancy period. Also, the presence of naked granuloma in histopathology, unlike most of the cases, contributes to the current histopathological data.
- Published
- 2020
46. A Prospective Study on Changes in Auricular Protrusion after Chronic Otitis Media Surgery with the Postauricular Approach.
- Author
-
Kim YH
- Subjects
- Cephalometry, Chronic Disease, Ear Auricle pathology, Ear Canal pathology, Ear Canal surgery, Ear Deformities, Acquired etiology, Female, Humans, Male, Middle Aged, Otitis Media surgery, Postoperative Complications etiology, Postoperative Period, Prospective Studies, Time Factors, Treatment Outcome, Ear Auricle surgery, Ear Deformities, Acquired pathology, Mastoidectomy adverse effects, Postoperative Complications pathology, Tympanoplasty adverse effects
- Abstract
Objectives: Some patients complain of apparent auricle protrusion after chronic otitis media (COM) surgery with the postauricular approach. This study investigates whether auricular protrusion could be restored to the preoperative state after COM surgery; if so, the time needed after surgery and whether the degree of auricular of protrusion differed according to the surgical procedure., Materials and Methods: Forty-seven patients who underwent tympanoplasty and canal wall up and canal wall down mastoidectomy between July 2016 and July 2017 were prospectively studied. To examine the degree of auricular protrusion, the longest distance from the head to the helical rim and the distance from the mastoid process to the helical rim in the plane along the level of the upper margin of the tragus were measured 1 day before surgery and 1 day; 2 weeks; and 1, 2, 4, and 6 months, postoperatively., Results: The superior aspect of the auricle returned to the preoperative state within 2 months of surgery, irrespective of the surgical procedure. The middle aspect was restored to the preoperative state within 4 months of tympanoplasty or canal wall up mastoidectomy, and within 2 months of canal wall down mastoidectomy., Conclusion: Postoperative auricular protrusion is a transient phenomenon.
- Published
- 2020
- Full Text
- View/download PDF
47. Lacaziosis (Lobomycosis) From Southern Mexico: A Case Confirmed by Molecular Biology.
- Author
-
Pech-Ortiz L, Maya-Aranda S, Hernández-Castro R, Xicohtencatl-Cortes J, Tirado-Sánchez A, and Bonifaz A
- Subjects
- Adult, Antifungal Agents therapeutic use, Clofazimine therapeutic use, Dermatomycoses complications, Dermatomycoses diagnosis, Dermatomycoses drug therapy, Dermatomycoses pathology, Drug Combinations, Ear, Ear Auricle microbiology, Ear Auricle pathology, Fibrosis pathology, Histocytochemistry, Humans, Lacazia classification, Lacazia cytology, Male, Mexico, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Lacazia isolation & purification, Lobomycosis complications, Lobomycosis diagnosis, Lobomycosis drug therapy, Lobomycosis pathology, Pathology, Molecular
- Published
- 2020
- Full Text
- View/download PDF
48. Milian's ear sign of erysipelas.
- Author
-
Shikino K and Ikusaka M
- Subjects
- Aged, Anti-Bacterial Agents administration & dosage, Diagnosis, Differential, Erythema diagnosis, Facial Pain diagnosis, Facial Pain etiology, Female, Fever diagnosis, Fever etiology, Humans, Treatment Outcome, Amoxicillin administration & dosage, Ear Auricle pathology, Erysipelas diagnosis, Erysipelas drug therapy, Erysipelas physiopathology, Orbital Cellulitis diagnosis, Polychondritis, Relapsing diagnosis
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2020
- Full Text
- View/download PDF
49. Neurofibromatosis type 2 initially presenting as a preauricular mass: a case report.
- Author
-
Lan WC, Aoh Y, Chen RY, Tien HC, and Lin CD
- Subjects
- Ear Auricle pathology, Humans, Magnetic Resonance Imaging, Male, Neurofibromatosis 2 complications, Neurofibromatosis 2 diagnostic imaging, Neurofibromatosis 2 pathology, Young Adult, Hearing Loss etiology, Neurofibromatosis 2 diagnosis
- Abstract
Neurofibromatosis type 2 (NF2) is a rare genetic disease involving multiple tumors of the central and peripheral nervous systems. Most patients with NF2 have bilateral vestibular schwannomas; nonvestibular schwannomas may also develop. While the majority of patients may present with hearing impairment, tinnitus, dizziness and balance disorders, some may present with cutaneous manifestations. We describe the case of a 20-year-old man who initially presented with a solitary subcutaneous painless nodule in the left preauricular area without any other symptoms. He received excisional biopsy for the preauricular mass and the pathologic diagnosis was schwannoma. Magnetic resonance imaging of brain and neck revealed multiple mass lesions over the bilateral cerebellopontine angle cisterns, extending to the bilateral internal auditory canals, bilateral cervical neuroforamens, cervical and upper thoracic spinal canals, and left posterior neck. The patient was diagnosed with NF2 according to the clinical criteria. He underwent gamma knife stereotactic radiosurgery for bilateral vestibular schwannomas and is now under regular monitoring. CONCLUSION: NF2 patients may present with an isolated solitary cutaneous schwannoma with no other associated clinical findings. Further assessment is thus warranted in young patients presenting with a peripheral schwannoma despite absence of other clinical findings.
- Published
- 2020
- Full Text
- View/download PDF
50. Duplication in ECR Near HMX1 and a SNP in GATA6 Genes Regulate Microtia in Awassi Sheep.
- Author
-
Jawasreh KIZ and Al-Omari HD
- Subjects
- Alleles, Animals, Breeding, Congenital Microtia pathology, Ear Auricle pathology, Genotype, Phenotype, Polymorphism, Single Nucleotide genetics, Sequence Analysis, DNA, Sheep physiology, Sheep, Domestic, Congenital Microtia genetics, Ear Auricle metabolism, GATA6 Transcription Factor genetics, Sheep genetics
- Abstract
Microtia and anotia are hereditary traits characterized by an underdevelopment or complete absence of the outer ear. These congenital malformations observed in many species can exist as part of various syndromes or as an isolated trait as seen in the fat-tailed Awassi sheep breed. Our study aims to identify the genetic mutations causing microtia in Awassi sheep by DNA sequencing. DNA was extracted from blood samples randomly collected from 84 Awassi sheep (16 earless, 41 short ear and 27 normal ear) across different farms. GATA6 exons 1, 2, 4, 6 and 7, CLRN1 intron 3, DCC intron 2, ECR near HMX1 and the intergenic region between GATA6 and MIB1 genes were screened, amplified and sequenced. Allele and genotype frequencies were calculated by direct counting. Association was performed using chi-squared test for goodness-of-fit. Results showed mutations in only two genes significantly associated with microtia in Awassi: duplication in part of ECR near HMX1 (6:114293121-6:114293196) and a SNP at GATA6 exon 7 (23:34498242). Association results revealed that the ECR locus accounts for the microtia phenotype, while GATA6 exon 7 acts as a modifier gene. Genetic screening for these loci can be used to improve selection against microtia in Awassi sheep.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.