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Purpose. As a scientific field, bioinformatics has drawn remarkable attention from various fields, such as information technology, mathematics, and modern biological sciences, in recent years. The topic models originating from the field of natural language processing have become the focus of attention with the rapid accumulation of biological datasets. Thus, this research is aimed at modeling the topic content of the bioinformatics literature presented by Iranian researchers in the Scopus Citation Database. Methodology. This research was a descriptive-exploratory study, and the studied population included 3899 papers indexed in the Scopus database, which had been indexed in this database until March 9, 2022. The topic modeling was then performed on the abstracts and titles of the papers. A combination of LDA and TF-IDF was utilized for topic modeling. Findings. The data analysis with topic modeling resulted in identifying seven main topics "Molecular Modeling," "Gene Expression," "Biomarker," "Coronavirus," "Immunoinformatics," "Cancer Bioinformatics," and "Systems Biology." Moreover, "Systems Biology" and "Coronavirus" had the largest and smallest clusters, respectively. Conclusion. The present investigation demonstrated an acceptable performance for the LDA algorithm in classifying the topics included in this field. The extracted topic clusters indicated excellent consistency and topic connection with each other. [ABSTRACT FROM AUTHOR]

Nowadays, scientific collaboration has dramatically increased due to web-based technologies, advanced communication systems, and information and scientific databases. The present study aims to provide a predictive model for author collaborations in bioinformatics research output using graph mining techniques and big data applications. The study is applied-developmental research adopting a mixed-method approach, i.e., a mix of quantitative and qualitative measures. The research population consisted of all bioinformatics research documents indexed in PubMed (n=699160). The correlations of bioinformatics articles were examined in terms of weight and strength based on article sections including title, abstract, keywords, journal title, and author affiliation using graph mining techniques and big data applications. Eventually, the prediction model of author collaboration in bioinformatics research was developed using the abovementioned tools and expertassigned weights. The calculations and data analysis were carried out using Expert Choice, Excel, Spark, and Scala, and Python programming languages in a big data server. Accordingly, the research was conducted in three phases: 1) identifying and weighting the factors contributing to authors' similarity measurement; 2) implementing co-authorship prediction model; and 3) integrating the first and second phases (i.e., integrating the weights obtained in the previous phases). The results showed that journal title, citation, article title, author affiliation, keywords, and abstract scored 0.374, 0.374, 0.091, 0.075, 0.055, and 0.031. Moreover, the journal title achieved the highest score in the model for the co-author recommender system. As the data in bibliometric information networks is static, it was proved remarkably effective to use content-based features for similarity measures. So that the recommender system can offer the most suitable collaboration suggestions. It is expected that the model works efficiently in other databases and provides suitable recommendations for author collaborations in other subject areas. By integrating expert opinion and systemic weights, the model can help alleviate the current information overload and facilitate collaborator lookup by authors. [ABSTRACT FROM AUTHOR]