Search

Your search keyword '"Ebrahimi, Ramin"' showing total 852 results
Start Over Author "Ebrahimi, Ramin"
852 results on '"Ebrahimi, Ramin"'

1. On definable subcategories

Author

Ebrahimi, Ramin

Subjects
Mathematics - Category Theory, Mathematics - Rings and Algebras, Mathematics - Representation Theory
Abstract

Let $\mathcal{X}$ be a skeletally small additive category. Using the canonical equivalence between two different presentations of the free abelian category over $\mathcal{X}$, we give a new and simple characterization of definable subcategories of $\rm Mod\text{-}\mathcal{X}$, and in particular definable subcategories of modules over rings. In the end, we give a conceptual proof of Auslander-Gruson-Jensen duality, which makes the duality between definable subcategories of left and right module more transparent.

Published
2024

3. Semibrick-cosilting correspondence

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, Mathematics - Rings and Algebras, 18E10, 18E20, 18E99
Abstract

Let $\Lambda$ be a finite dimensional algebra. In this paper we show that there is a natural bijection between cosilting modules in Mod$\Lambda$ and semibricks in Mod$\Lambda$ satisfying some condition. Also this bijection restricts to a bijection between all semibricks in mod$\Lambda$ and a certain subclass of cosilting modules. These bijections are generalizations of Asai's correspondence [7] between support $\tau^-$-tilting modules and right finite semibricks.

Published
2024

5. Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans.

Author

Ebrahimi, Ramin, Dennis, Paul, Alvarez, Carlos, Shroyer, A, Beckham, Jean, and Sumner, Jennifer

Subjects
PTSD, stroke, transient ischemic attack, women veterans, Humans, Female, Adolescent, Adult, Middle Aged, Ischemic Attack, Transient, Stress Disorders, Post-Traumatic, Retrospective Studies, Veterans, Longitudinal Studies, Stroke, Risk Factors
Abstract

BACKGROUND: Posttraumatic stress disorder (PTSD) has been associated with ischemic heart disease in women veterans, but evidence for associations with other cardiovascular disorders remains limited in this population. This retrospective longitudinal cohort study evaluated the association of PTSD with incident stroke/transient ischemic attack (TIA) in women veterans. METHODS AND RESULTS: Veterans Health Administration electronic health records were used to identify women veterans aged ≥18 years engaged with Veterans Health Administration health care from January 1, 2000 to December 31, 2019. We identified women veterans with and without PTSD without a history of stroke or TIA at start of follow-up. Propensity score matching was used to match groups on age, race or ethnicity, traditional cardiovascular risk factors, female-specific risk factors, a range of mental and physical health conditions, and number of prior health care visits. PTSD, stroke, TIA, and risk factors used in propensity score matching were based on diagnostic codes. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for associations of PTSD with an incident stroke/TIA composite. Subanalyses considered stroke and TIA separately, plus age- and race- or ethnicity-stratified analyses were carried out. The analytic sample included 208 092 women veterans (104 046 with and 104 046 without PTSD). PTSD was associated with a greater rate of developing stroke/TIA (HR, 1.33 [95% CI, 1.25-1.42], P

Published
2024

6. Effect of SGLT-2 inhibitors on arrhythmia events: insight from an updated secondary analysis of > 80,000 patients (the SGLT2i—Arrhythmias and Sudden Cardiac Death)

Author

Liao, Jia, Ebrahimi, Ramin, Ling, Zhiyu, Meyer, Christian, Martinek, Martin, Sommer, Philipp, Futyma, Piotr, Di Vece, Davide, Schratter, Alexandra, Acou, Willem-Jan, Zhu, Lin, Kiuchi, Márcio G., Liu, Shaowen, Yin, Yuehui, Pürerfellner, Helmut, Templin, Christian, and Chen, Shaojie

Published
2024
Full Text
View/download PDF

7. A self-assembled implantable microtubular pacemaker for wireless cardiac electrotherapy.

Author

Wang, Shaolei, Cui, Qingyu, Abiri, Parinaz, Roustaei, Mehrdad, Zhu, Enbo, Li, Yan-Ruide, Wang, Kaidong, Duarte, Sandra, Yang, Lili, Ebrahimi, Ramin, Bersohn, Malcolm, Hsiai, Tzung, and Chen, Jun

Subjects
Animals, Swine, Cardiac Pacing, Artificial, Pacemaker, Artificial, Prostheses and Implants, Heart, Electric Stimulation, Equipment Design, Treatment Outcome
Abstract

The current cardiac pacemakers are battery dependent, and the pacing leads are prone to introduce valve damage and infection, plus a complete pacemaker retrieval is needed for battery replacement. Despite the reported wireless bioelectronics to pace the epicardium, open-chest surgery (thoracotomy) is required to implant the device, and the procedure is invasive, requiring prolonged wound healing and health care burden. We hereby demonstrate a fully biocompatible wireless microelectronics with a self-assembled design that can be rolled into a lightweight microtubular pacemaker for intravascular implantation and pacing. The radio frequency was used to transfer energy to the microtubular pacemaker for electrical stimulation. We show that this pacemaker provides effective pacing to restore cardiac contraction from a nonbeating heart and have the capacity to perform overdrive pacing to augment blood circulation in an anesthetized pig model. Thus, this microtubular pacemaker paves the way for the minimally invasive implantation of leadless and battery-free microelectronics.

Published
2023

8. Iodine-Induced Hypothyroidism and Long-Term Risks of Incident Heart Failure.

Author

Inoue, Kosuke, Guo, Rong, Lee, Martin, Neverova, Natalia, Ebrahimi, Ramin, Currier, Jesse, Bashir, Muhammad, and Leung, Angela

Subjects
heart failure, hypothyroidism, iodine, thyroid dysfunction, Adult, Male, Humans, Female, Adolescent, Middle Aged, Aged, Cohort Studies, Hypothyroidism, Heart Failure, Thyrotropin, Iodine
Abstract

Background Although most individuals can adapt to a large iodine load and remain euthyroid, hypothyroidism can develop after iodine exposure. Hypothyroidism is associated with adverse cardiovascular consequences, including heart failure. This study was performed to investigate the relationships between iodine-induced hypothyroidism and incident heart failure. Methods and Results This cohort study of the US Veterans Health Administration (1998-2021) included adults aged ≥18 years with a serum thyroid-stimulating hormone (thyrotropin)

Published
2023

10. Iodine-Induced Hyperthyroidism and Long-term Risks of Incident Atrial Fibrillation and Flutter.

Author

Inoue, Kosuke, Guo, Rong, Lee, Martin, Ebrahimi, Ramin, Neverova, Natalia, Currier, Jesse, Bashir, Muhammad, and Leung, Angela

Subjects
arrhythmia, atrial fibrillation, hyperthyroidism, iodine, thyroid dysfunction, Male, Female, Humans, Middle Aged, Aged, Adolescent, Atrial Fibrillation, Retrospective Studies, Hyperthyroidism, Atrial Flutter, Iodine, Thyrotropin, Risk Factors
Abstract

CONTEXT: Although iodine-induced hyperthyroidism is a potential consequence of iodinated radiologic contrast administration, its association with long-term cardiovascular outcomes has not been previously studied. OBJECTIVE: To investigate the relationships between hyperthyroidism observed after iodine contrast administration and incident atrial fibrillation/flutter. METHODS: Retrospective cohort study of the U.S. Veterans Health Administration (1998-2021) of patients age ≥18 years with a normal baseline serum thyrotropin (TSH) concentration, subsequent TSH

Published
2023

11. The completion of $d$-abelian categories

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, Mathematics - Category Theory, 18E10, 18E20, 18E99
Abstract

Let $A$ be a finite-dimensional algebra, and $\mathfrak{M}$ be a $d$-cluster tilting subcategory of mod$A$. From the viewpoint of higher homological algebra, a natural question to ask is when $\mathfrak{M}$ induces a $d$-cluster tilting subcategory in Mod$A$. In this paper, we investigate this question in a more general form. Let $\mathcal{M}$ be a small $d$-abelian category of an abelian category $\mathcal{A}$. The completion of $\mathcal{M}$, denoted by Ind$(\mathcal{M})$, is defined as the universal completion of $\mathcal{M}$ with respect to filtered colimits. We explore Ind$(\mathcal{M})$ and demonstrate its equivalence to the full subcategory $\mathcal{L}_d(\mathcal{M})$ of Mod$\mathcal{M}$, comprising left $d$-exact functors. Notably, while Ind$(\mathcal{M})$ as a subcategory of $\frac{Mod\mathcal{M}}{Eff(\mathcal{M})}$, satisfies all properties of a $d$-cluster tilting subcategory except $d$-rigidity, it falls short of being a $d$-cluster tilting category. For a $d$-cluster tilting subcategory $\mathfrak{M}$ of mod$A$, $\overrightarrow{\mathfrak{M}}$, consists of all filtered colimits of objects from $\mathfrak{M}$, is a generating-cogenerating, functorially finite subcategory of Mod$A$. The question of whether $\mathfrak{M}$ is a $d$-rigid subcategory remains unanswered. However, if it is indeed $d$-rigid, it qualifies as a $d$-cluster tilting subcategory. In the case $d=2$, employing cotorsion theory, we establish that $\overrightarrow{\mathfrak{M}}$ is a $2$-cluster tilting subcategory if and only if $\mathfrak{M}$ is of finite type. Thus, the question regarding whether $\overrightarrow{\mathfrak{M}}$ is a $d$-cluster tilting subcategory of Mod$ A$ appears to be equivalent to the Iyama's qestion about the finiteness of $\mathfrak{M}$.

Published
2022

12. Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans.

Author

Akiba, Yasutada, Leung, Angela M, Bashir, Muhammad-Tariq, Ebrahimi, Ramin, Currier, Jesse W, Neverova, Natalia, and Kaunitz, Jonathan D

Subjects
Humans, Iodides, Iodine, Anti-Infective Agents, Anti-Bacterial Agents, Coronary Angiography, United States, Infectious Diseases, Clinical Research
Abstract

The lactoperoxidase (LPO)-hydrogen peroxide-halides reaction (LPO system) converts iodide and thiocyanate (SCN-) into hypoiodous acid (HOI) and hypothiocyanite (OSCN-), respectively. Since this system has been implicated in defense of the airways and oropharynx from microbial invasion, in this proof-of-concept study we measured the concentrations of these analytes in human saliva from a convenience clinical sample of 40 qualifying subjects before and after acute iodine administration via the iodinated contrast medium used in coronary angiography to test the hypothesis that an iodide load increases salivary iodide and HOI concentrations. Saliva was collected and salivary iodide, SCN-, HOI and OSCN- were measured using standard methodology. The large iodine load delivered by the angiographic dye, several 100-fold in excess of the U.S. Recommended Daily Allowance for iodine (150 µg/day), significantly increased salivary iodide and HOI levels compared with baseline levels, whereas there was no significant change in salivary SCN- and OSCN- levels. Iodine load and changes of salivary iodide and HOI levels were positively correlated, suggesting that higher iodide in the circulation increases iodide output and salivary HOI production. This first of its kind study suggests that a sufficient but safe iodide supplementation less than the Tolerable Upper Limit for iodine set by the U.S. Institute of Medicine (1,100 µg/day) may augment the generation of antimicrobial HOI by the salivary LPO system in concentrations sufficient to at least in theory protect the host against susceptible airborne microbial pathogens, including enveloped viruses such as coronaviruses and influenza viruses.

Published
2022

13. $n\mathbb{Z}$-abelian and $n\mathbb{Z}$-exact categories

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Category Theory, Mathematics - K-Theory and Homology, Mathematics - Representation Theory, 18E99, 16E30
Abstract

In this paper we introduce $n\mathbb{Z}$-abelian and $n\mathbb{Z}$-exact categories by axiomatising properties of $n\mathbb{Z}$-cluster tilting subcategories. We study this categories and show that every $n\mathbb{Z}$-cluster tilting subcategory of an abelian (resp., exact) category has a natural structure of an $n\mathbb{Z}$-abelian (resp., $n\mathbb{Z}$-exact) category. Also we show that every small $n\mathbb{Z}$-abelian category arise in this way, and discuss the problem for $n\mathbb{Z}$-exact categories.

Published
2022

15. Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Schweiger, Victor, Cammann, Victoria L., Crisci, Giulia, Gilhofer, Thomas, Schlenker, Rabea, Niederseer, David, Chen, Shaojie, Ebrahimi, Ramin, Wenzl, Florian, Würdinger, Michael, Citro, Rodolfo, Vecchione, Carmine, Gili, Sebastiano, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Miłosz, Noutsias, Michel, Knorr, Maike, Jansen, Thomas, D’Ascenzo, Fabrizio, Dichtl, Wolfgang, von Lewinski, Dirk, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang, Pott, Alexander, Meyer, Philippe, Roffi, Marco, Banning, Adrian, Wolfrum, Mathias, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Napp, L. Christian, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clément, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Poledniková, Karolina, Toušek, Petr, Winchester, David E., Massoomi, Michael, Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Hauck, Christian, Paolini, Carla, Bilato, Claudio, Kobayashi, Yoshio, Kato, Ken, Ishibashi, Iwao, Himi, Toshiharu, Din, Jehangir, Al-Shammari, Ali, Prasad, Abhiram, Rihal, Charanjit S., Liu, Kan, Schulze, P. Christian, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Pestana, Gonçalo, Nguyen, Thanh H., Böhm, Michael, Maier, Lars S., Pinto, Fausto J., Widimský, Petr, Felix, Stephan B., Braun-Dullaeus, Ruediger C., Rottbauer, Wolfgang, Hasenfuß, Gerd, Pieske, Burkert M., Schunkert, Heribert, Budnik, Monika, Opolski, Grzegorz, Thiele, Holger, Bauersachs, Johann, Horowitz, John D., Di Mario, Carlo, Kong, William, Dalakoti, Mayank, Imori, Yoichi, Münzel, Thomas, Liberale, Luca, Montecucco, Fabrizio, Bax, Jeroen J., Crea, Filippo, Ruschitzka, Frank, Lüscher, Thomas F., Ghadri, Jelena R., Bossone, Eduardo, Templin, Christian, and Di Vece, Davide

Published
2024
Full Text
View/download PDF

16. Higher Auslander correspondence for exact categories

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, 18E99, 18E40
Abstract

Inspired by the recent work of Henrard, Kvamme and van Roosmalen [17], we prove a categorified version of higher Auslander correspondence in the context of exact categories. We define n-Auslander exact categories and show that there is a bijection between the equivalence classes of n-cluster tilting subcategories of exact categories and the equivalence classes of n-Auslander exact categories., Comment: arXiv admin note: text overlap with arXiv:2011.15107 by other authors

Published
2021

17. Yoneda extensions of abelian quotient categories

Author

Ebrahimi, Ramin

Subjects
Mathematics - Category Theory
Abstract

Let $\mathcal{A}$ be a essentially small abelian category and $\mathcal{C}$ be a Serre subcategory of $\mathcal{A}$. Consider the quotient functor $q:\mathcal{A}\rightarrow \mathcal{A}/\mathcal{C}$. For an object $A\in \mathcal{A}$ and a non-negative integer $k$ we investigate when the natural map $q_{X,A}^i: \rm Ext^i_{\mathcal{A}}(X,A)\rightarrow Ext^i_{\mathcal{A}/\mathcal{C}}(q(X),q(A))$ is invertible for every $X\in \mathcal{A}$ and every $i\in\{0,1,\cdots,k\}$. In the end we give an application of the main theorem., Comment: Revised version following referee's report. Comments are welcome!

Published
2021

19. 3-Dimensional electrical impedance spectroscopy for in situ endoluminal mapping of metabolically active plaques.

Author

Abiri, Parinaz, Luo, Yuan, Huang, Zi-Yu, Cui, Qingyu, Duarte-Vogel, Sandra, Roustaei, Mehrdad, Chang, Chih-Chiang, Xiao, Xiao, Packard, Rene, Cavallero, Susana, Ebrahimi, Ramin, Benharash, Peyman, Chen, Jun, Tai, Yu-Chong, and Hsiai, Tzung

Subjects
3-D histology for conductivity modeling, Electrical impedance spectroscopy (EIS), Electrical impedance tomography (EIT), Intravascular microelectrode array, Metabolically active plaque
Abstract

Electrical impedance spectroscopy (EIS) has been recognized to characterize oxidized low-density lipoprotein (oxLDL) in the metabolically active plaque. However, intravascular deployment of 3-D EIS-derived electrical impedance tomography (EIT) for endoluminal mapping of oxLDL-laden arterial walls remains an unmet clinical challenge. To this end, we designed the 6-point microelectrode arrays that were circumferentially configurated onto the balloon catheter for 15 intravascular EIS permutations. In parallel, we created the metabolically active plaques by performing partial ligation of right carotid artery in Yorkshire mini-pigs (n = 6 males), followed by demonstrating the plaque progression at baseline, 8 weeks, and 16 weeks of high-fat diet via computed tomography (CT) angiogram. Next, we deployed the 3-D EIS sensors to the right and left carotid arteries, and we demonstrated 3-D EIS mapping of metabolically active endolumen in the right but not left carotid arteries as evidenced by the positive E06 immunostaining for oxLDL-laden regions. By considering electrical conductivity (σ) and permittivity (ε) properties of collagen, lipid, and smooth muscle presence in the arterial wall, we further validated the 3-D EIS-derived EIT by reconstructing the histology of right and left carotid arteries for the finite element modeling of the oxLDL-laden endolumen, and we accurately predicted 3-D EIS mapping. Thus, we establish the capability of 3-D EIS-derived EIT to detect oxLDL-laden arterial walls with translational implication to predict metabolically active plaques prone to acute coronary syndromes or stroke.

Published
2022

20. Iodine contrast exposure and incident COVID-19 infection.

Author

Tsai, Karen, Inoue, Kosuke, McClean, Michael, Kaunitz, Jonathan D, Akiba, Yasutada, Lee, Martin L, Neverova, Natalia V, Currier, Jesse W, Ebrahimi, Ramin, Bashir, Muhammad T, and Leung, Angela M

Subjects
COVID-19, SARS-CoV-2, Veterans, iodinated contrast, iodine, Prevention, Vaccine Related, Infectious Diseases, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being
Abstract

BackgroundIodine and particularly its oxidated forms have long been recognized for its effective antiseptic properties. Limited in vitro and in vivo data suggest that iodine exposure may rapidly inactivate, reduce transmission, and reduce infectivity of SARS-CoV-2. We hypothesized that iodine exposure may be associated with decreased incident COVID-19 infection.MethodsA retrospective population-level cohort analysis was performed of the U.S. Veterans Health Administration between 1 March 2020 and 31 December 2020, before the widespread availability of vaccines against SARS-CoV-2. Multivariable logistic regression models estimated the adjusted odds ratios (OR) and 95% confidence intervals (CI) of the associations between iodinated contrast exposure and incident COVID-19 infection, adjusting for age, sex, race/ethnicity, place of residence, socioeconomic status, and insurance status.Results530,942 COVID-19 tests from 333,841 Veterans (mean ± SD age, 62.7 ± 15.2 years; 90.2% men; 61.9% non-Hispanic Whites) were analyzed, of whom 9% had received iodinated contrast ≤60 days of a COVID-19 test. Iodine exposure was associated with decreased incident COVID-19 test positivity (OR, 0.75 95% CI, 0.71-0.78). In stratified analyses, the associations between iodinated contrast use and decreased COVID-19 infection risk did not differ by age, sex, and race/ethnicity.ConclusionIodine exposure may be protective against incident COVID-19 infection. Weighed against the risks of supraphysiologic iodine intake, dietary, and supplemental iodine nutrition not to exceed its Tolerable Upper Limit may confer an antimicrobial benefit against SARS-CoV-2. A safe but antimicrobial level of iodine supplementation may be considered in susceptible individuals, particularly in geographic regions where effective COVID-19 vaccines are not yet readily available.

Published
2022

23. Gabriel-Quillen embedding for $n$-exact categories

Author

Ebrahimi, Ramin

Subjects
Mathematics - Representation Theory
Abstract

Our first aim is to provide an analog of the Gabriel-Quillen embedding theorem for $n$-exact categories. Also we give an example of an $n$-exact category that is not an $n$-cluster tilting subcategory, and we suggest two possible ways for realizing $n$-exact categories as $n$-cluster tilting subcategory., Comment: 11 pages, v3: author accepted manuscript, to appear in Communications in Algebra, Proposition 3.8 (proving that H detects n-exact sequences) has been added

Published
2020

24. Higher Auslander's formula

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, Mathematics - Category Theory, 18E10, 18E20, 18E99
Abstract

Let $\mathcal{M}$ be a small $n$-abelian category. We show that the category of finitely presented functors $mod$-$\mathcal{M}$ modulo the subcategory of effaceable functors $mod_0$-$\mathcal{M}$ has an $n$-cluster tilting subcategory which is equivalent to $\mathcal{M}$. This gives a higher-dimensional version of Auslander's formula., Comment: arXiv admin note: text overlap with arXiv:2001.01254

Published
2020
Full Text
View/download PDF

25. Representation of n-abelian categories in abelian categories

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, Mathematics - Category Theory, 18E10, 18E20, 18E99
Abstract

Let $\mathcal{M}$ be a small $n$-abelian category. We show that the category of absolutely pure group valued functors over $\mathcal{M}$, denote by $\mathcal{L}_2(\mathcal{M},\mathcal{G})$, is an abelian category and $\mathcal{M}$ is equivalent to a full subcategory of $\mathcal{L}_2(\mathcal{M},\mathcal{G})$ in such a way that $n$-kernels and $n$-cokernels are precisely exact sequences of $\mathcal{L}_2(\mathcal{M},\mathcal{G})$ with terms in $\mathcal{M}$. This gives a higher-dimensional version of the Freyd-Mitchell embedding theorem for $n$-abelian categories.

Published
2020

26. Key dimensions of post-traumatic stress disorder and endothelial dysfunction: a protocol for a mechanism-focused cohort study.

Author

Cleveland, Shiloh, Reed, Kristina, Thomas, Jordan L, Ajijola, Olujimi A, Ebrahimi, Ramin, Hsiai, Tzung, Lazarov, Amit, Montoya, Amanda K, Neria, Yuval, Shimbo, Daichi, Wolitzky-Taylor, Kate, and Sumner, Jennifer A

Subjects
Brachial Artery, Humans, Cohort Studies, Fear, Stress Disorders, Post-Traumatic, Adult, Los Angeles, Female, Male, adult psychiatry, anxiety disorders, cardiology, Cardiovascular, Behavioral and Social Science, Prevention, Clinical Research, Post-Traumatic Stress Disorder (PTSD), Anxiety Disorders, Mental Health, Mental health, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionBoth trauma exposure and post-traumatic stress disorder (PTSD) are associated with increased risk of cardiovascular disease (CVD), the leading cause of death in the USA. Endothelial dysfunction, a modifiable, early marker of CVD risk, may represent a physiological mechanism underlying this association. This mechanism-focused cohort study aims to investigate the relationship between PTSD (both in terms of diagnosis and underlying symptom dimensions) and endothelial dysfunction in a diverse, community-based sample of adult men and women.Methods and analysisUsing a cohort design, 160 trauma-exposed participants without a history of CVD are designated to the PTSD group (n=80) or trauma-exposed matched control group (n=80) after a baseline diagnostic interview assessment. Participants in the PTSD group have a current (past month) diagnosis of PTSD, whereas those in the control group have a history of trauma but no current or past psychiatric diagnoses. Endothelial dysfunction is assessed via flow-mediated vasodilation of the brachial artery and circulating levels of endothelial cell-derived microparticles. Two higher order symptom dimensions of PTSD-fear and dysphoria-are measured objectively with a fear conditioning paradigm and attention allocation task, respectively. Autonomic imbalance, inflammation, and oxidative stress are additionally assessed and will be examined as potential pathway variables linking PTSD and its dimensions with endothelial dysfunction. Participants are invited to return for a 2-year follow-up visit to reassess PTSD and its dimensions and endothelial dysfunction in order to investigate longitudinal associations.Ethics and disseminationThis study is conducted in compliance with the Helsinki Declaration and University of California, Los Angeles Institutional Review Board. The results of this study will be disseminated via articles in peer-reviewed journals and presentations at academic conferences and to community partners.Trial registration numberNCT03778307; pre-results.

Published
2021

27. Using the adherence‐efficacy relationship of emtricitabine and tenofovir disoproxil fumarate to calculate background HIV incidence: a secondary analysis of a randomized, controlled trial

Author

Glidden, David V, Das, Moupali, Dunn, David T, Ebrahimi, Ramin, Zhao, Yongwu, Stirrup, Oliver T, Baeten, Jared M, and Anderson, Peter L

Subjects
HIV/AIDS, Sexual and Gender Minorities (SGM/LGBT*), Prevention, Clinical Trials and Supportive Activities, Infectious Diseases, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Anti-HIV Agents, Bayes Theorem, Emtricitabine, Female, HIV Infections, Homosexuality, Male, Humans, Male, Pre-Exposure Prophylaxis, Sexual and Gender Minorities, Tenofovir, counterfactual, PrEP, clinical trial design, tenofovir alafenamide, tenofovir disoproxil fumarate, Bayesian inference, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionRandomized trials of new agents for HIV pre-exposure prophylaxis (PrEP) compare against emtricitabine and tenofovir disoproxil fumarate (F/TDF), without a placebo group. We used the well-characterized adherence-efficacy relationship for F/TDF to back-calculate the (non-PrEP) counterfactual background HIV incidence (bHIV) in a randomized trial of a novel PrEP agent and estimate comparative efficacy (to counterfactual bHIV).MethodsThe DISCOVER trial (ClinicalTrials.gov: NCT02842086) randomized 5387 men who have sex with men (MSM) and transgender women who have sex with men and demonstrated non-inferiority of emtricitabine and tenofovir alafenamide (F/TAF) to F/TDF (HIV incidence rate ratio [IRR] 0·47, 95% CI: 0·19 to 1.15). Tenofovir diphosphate (TFV-DP) levels in dried blood spots (DBS) were assessed for all diagnosed with HIV and in a random 10% of the cohort. We used a Bayesian model with a diffuse prior distribution, derived from established data relating tenofovir diphosphate levels to HIV prevention efficacy. This prior, combined with the F/TDF seroconversion rate and tenofovir diphosphate levels in DISCOVER, yielded Bayesian inferences on the counterfactual bHIV.ResultsThere were six versus 11 postbaseline HIV infections (0.14 vs. 0.25/100 person-years [PY]) on F/TAF and F/TDF respectively. Of the 11 on F/TDF, 10 had low, none had medium and one had high tenofovir diphosphate levels; among HIV-negative controls, 5% of the person-time years had low, 9% had medium and 86% had high TFV-DP levels. A non-informative prior distribution for counterfactual bHIV, combined with the prior for TFV-DP level-efficacy relationship, yielded a posterior counterfactual bHIV of 3·4 infections/100 PY (0.80 Bayesian credible interval [CrI] 1·9 to 5·9), which suggests a median HIV efficacy of 96% (0.95 CrI [88% to 99%]) for F/TAF and 93% (0.95 CrI [87% to 96%]) for F/TDF compared to bHIV.ConclusionsBased on the established connection of drug concentrations to PrEP prevention efficacy, a Bayesian framework can be used to estimate a synthetic non-PrEP control group in randomized, active-controlled PrEP trials that include a F/TDF-comparator group.

Published
2021

30. Pure semisimple $n$-cluster tilting subcategories

Author

Ebrahimi, Ramin and Nasr-Isfahani, Alireza

Subjects
Mathematics - Representation Theory, Mathematics - Rings and Algebras
Abstract

From the viewpoint of higher homological algebra, we introduce pure semisimple $n$-abelian category, which is analogs of pure semisimple abelian category. Let $\Lambda$ be an Artin algebra and $\mathcal{M}$ be an $n$-cluster tilting subcategory of $Mod$-$\Lambda$. We show that $\mathcal{M}$ is pure semisimple if and only if each module in $\mathcal{M}$ is a direct sum of finitely generated modules. Let $\mathfrak{m}$ be an $n$-cluster tilting subcategory of $mod$-$\Lambda$. We show that $Add(\mathfrak{m})$ is an $n$-cluster tilting subcategory of $Mod$-$\Lambda$ if and only if $\mathfrak{m}$ has an additive generator if and only if $Mod(\mathfrak{m})$ is locally finite. This generalizes Auslander's classical results on pure semisimplicity of Artin algebras., Comment: to appear in Journal of Algebra

Published
2019

31. Effect of metformin alone and in combination with etoposide and epirubicin on proliferation, apoptosis, necrosis, and migration of B-CPAP and SW cells as thyroid cancer cell lines

Author

Ghazaleh Ghavami, Ebrahimi Ramin Kiasari, Faezeh Pakzad, and Soroush Sardari

Subjects
epirubicin, etoposide, metformin, synergism, thyroid cancer., Pharmacy and materia medica, RS1-441
Abstract

Background and purpose: There has not been a comprehensive study on the simultaneous effects of metformin, etoposide, and epirubicin on thyroid cancer cells. Hence, the current research proposed the in vitro study on the effect of metformin alone and in combination with etoposide and epirubicin on the rate of proliferation, apoptosis, necrosis, and migration against B-CPAP and SW-1736 cells as thyroid cancer cell lines. Experimental approach: MTT-based proliferation assay, combination index method, flow cytometry, and scratch wound healing assays were used to evaluate the simultaneous effects of the three approved drugs against thyroid cancer cells. Findings/Results: This study showed that the toxic concentration of metformin on normal Hu02 cells was more than 10 folds higher than B-CPAP and SW cancerous cells. Metformin in combination with epirubicin and etoposide could increase percentages of B-CPAP and SW cells in early and late apoptosis and necrosis phases in comparison with their single concentrations, significantly. Metformin in combination with epirubicin and etoposide could arrest the S phase in B-CPAP and SW cells, significantly. Metformin in combination with epirubicin and etoposide could reduce ~100% migration rate, whereas single concentrations of epirubicin and etoposide could reduce ~50% migration rate. Conclusion and implication: Combined treatment of metformin with anticancer drugs epirubicin and etoposide can increase the mortality in thyroid cancer cell lines and reduce the toxicity of these drugs on the normal cell line, which could be the starting point for proposing a new combination strategy in the therapy of thyroid cancer to induce more potency and reduce acute toxicity.

Published
2023
Full Text
View/download PDF

36. Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial

Author

Carson, Jeffrey L., Ghafghazi, Shahab, Cooper, Howard A., Wood, Frances, Menegus, Mark, Uretsky, Barry, Vallurupalli, Srikanth, Maniatis, Gregory, Gruberg, Luis, Roswell, Robert, Rossi, Joseph, Abtahian, Farhad, Tessalee, Meechai, Barsness, Gregory, Abbott, J. Dawn, Aronow, Herbert, Ramanathan, Kodangudi, Schmidhofer, Mark, Keating, Friederike, Carson, Michael, Kontos, Michael, Qureshi, Mansoor, Clegg, Stacey, Laskey, Warren, Polonsky, Tamar, Gupta, Rajesh, Sheikh, Mujeeb Abdul, Uhl, Lynne, Mullen, Paul, Bracey, Arthur, Matthai, William, Stowell, Christopher, Dudzinski, David, Marhefka, Gregary, Weinstock, Perry, Lawson, William, Keller, Norma, Yuriditsky, Eugene, Thomas, Michael, Jacobs, Alice, Hochberg, Claudia, Siddiqi, Omar, Schulman-Marcus, Joshua, Torosoff, Mikhail, Gitter, Michael, Dai, Xuming, Traverse, Jay, McCamant, Eric, Scott, Jason, Swaminathan, Rajesh, Rao, Sunil, Goldsweig, Andrew M., DeFilippis, Andrew P., Salisbury, Adam, Landers, David, Raveendran, Ganesh, Ebrahimi, Ramin, Bach, Richard, Delehanty, Joseph, Shah, Raj C., Brener, Sorin, Doroshow, Jonathan, Caixeta, Adriano, Precoma, Dalton, Dall'Orto, Frederico Toledo Campo, De Andrade, Pedro Beraldo, Dracoulakis, Marianna, Maia, Lília Nigro, Ritt, Luiz Eduardo Fontelles, Quadros, Alexandre, Filho, Dário Celestino Sobral, De Martino, Fernando, Huynh, Thao, Schnell, Greg, Senaratne, Manohara, Tandon, Vikas, Neary, John, Laflamme, David, Dery, Jean-Pierre, Bainey, Kevin, Haichin, Richard, Dehghani, Payam, Quraishi, Ata Ur Rehman, Potter, Brian J., Carrier, François Martin, Goldfarb, Michael, Fordyce, Christopher, Sia, Ying Tung, Daneault, Benoit, Madan, Mina, McPherson, Terry, Ducas, John, Minhas, Kunal, Brass, Neil, Bagai, Akshay, Robinson, Simon, Džavík, Vladimír, Khan, Razi, Michaud, Nicolas, Steg, Gabriel, Ducrocq, Gregory, Puymirat, Etienne, Lemesle, Gilles, Ferrari, Emile, Lattuca, Benoit, Silvain, Johanne, Vanzetto, Gérald, Cetran, Laura, Lhermusier, Thibault, Cottin, Yves, Rosamel, Yann, Angoulvant, Denis, Dillinger, Jean Guillaume, Thuaire, Christophe, Popovic, Batric, Durand, Eric, Bouleti, Claire, Roubille, François, Delorme, Laurent, Crozier, Ian, Benatar, Jocelyne, Nandra, Samraj, Ternouth, Ian, Fisher, Nick, Brieger, David, Hillis, Graham, Brooks, Maria Mori, Chaitman, Bernard R., Alexander, John H., Goodman, Shaun G., Bertolet, Marnie, Rao, Sunil V., Triulzi, Darrell J., Fergusson, Dean A., Kostis, William J., Noveck, Helaine, Simon, Tabassome, Steg, Philippe Gabriel, Lopes, Renato D., White, Harvey, Alsweiler, Caroline, Morton, Erin, and Hébert, Paul C.

Published
2023
Full Text
View/download PDF

41. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
Full Text
View/download PDF

42. 3D Map Combined with Transthoracic Echocardiography for Ablation of Premature Ventricular Contractions/Ventricular Arrhythmia from Papillary Muscle: A Technical Report.

Author

Mirzeyeva, Gozal, Heukäufer, Matthias, Janschel, Sarah, Schneppe, Daniel, Ebrahimi, Ramin, Dörr, Marcus, Kiuchi, Márcio Galindo, Futyma, Piotr, Martinek, Martin, Pürerfellner, Helmut, Templin, Christian, and Chen, Shaojie

Subjects
ARRHYTHMIA, VENTRICULAR arrhythmia, PAPILLARY muscles, CATHETER ablation, ECHOCARDIOGRAPHY
Abstract

Ventricular arrhythmias originating from the papillary muscle of the ventricles are complex clinical problems. Catheter ablation has the potential to cure these arrhythmias. However, the procedure is usually challenging due to the specific anatomy, catheter instability and difficulty in localization of the origin of the arrhythmias. Intracardiac echocardiography (ICE) has been reported to be the suitable imaging method for assessing the location of focus in papillary muscles. We used transthoracic echocardiography (TTE), as a noninvasive cost-effective imaging supporting modality, in combination with 3D mapping to guide the exact localization and successful ablation of papillary muscle-originating premature ventricular contractions (PVCs). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

47. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Antinori, Andrea, Apea, Vanessa, Asmuth, David, Avery, Ann, Benson, Paul, Bergin, Colm, Berhe, Mezgebe, Brar, Indira, Brinson, Cynthia, Brunetta, Jason, Burack, Jeffrey, Campbell, Thomas, Cespedes, Michelle, Clarke, Amanda, Coleman, Megan, Coll, Josep, Crespo Casal, Manuel, Creticos, Catherine, Crofoot, Gordon, Cruickshank, Frederick, Cua, Eric, Daar, Eric, de Wet, Joseph, DeJesus, Edwin, Del Romero Guerrero, Jorge, Dinges, William, Doblecki-Lewis, Susanne, Donovan, Taylor, Dosekun, Olamide, Flamm, Jason, Gallant, Joel, Gerstoft, Jan, Gilson, Richard, Gladstein, Jay, Grant, Robert, Grossberg, Robert, Haas, Bernhard, Halperin, Jason, Hardy, W. David, Hare, Charles, Hassler, Shawn, Hengel, Richard, Henry, William, Hodge, Theo, Jr., Hosek, Sybil, Hurt, Christopher, Iandiorio, Michelle, Jessen, Heiko, Kegg, Stephen, Knecht, Gabriele, Kronborg, Gitte, Krznaric, Ivanka, LaMarca, Anthony, Larsen, Carsten Schade, Larsen, Olav Ditlevsen, Lazzarin, Adriano, Leen, Clifford, Lucasti, Christopher, Mallon, Patrick, Mannheimer, Sharon, Markowitz, Martin, Martorell, Claudia, Mayer, Kenneth, Mills, Anthony, Molina, Jean-Michel, Morris, Sheldon, Mounzer, Karam, Nwokolo, Nneka, Ogbuagu, Onyema, Osiyemi, Olayemi, Petroll, Andrew, Philibert, Patrick, Phoenix, John, Pialoux, Gilles, Podzamczer, Daniel, Post, Frank, Prins, Maria, Ramgopal, Moti, Rashbaum, Bruce, Reeves, Iain, Richmond, Gary, Rieger, Armin, Ruane, Peter, Salazar, Laura, Scarsella, Anthony, Schembri, Gabriel, Scott, Mia, Shalit, Peter, Sinclair, Gary, Sobieszczyk, Magdalena, Spinner, Christoph, Stephens, Jeffrey, Szabo, Jason, Taylor, Stephen, Thompson, Melanie, Tremblay, Cecile, Trottier, Benoit, Voskuhl, Gene, Wade, Barbara, Wohl, David, Workowski, Kimberly, Yawetz, Sigal, Young, Benjamin, Ruane, Peter J, Salazar, Laura C, Henry, Keith, Asmuth, David M, Shao, Yongwu, Ebrahimi, Ramin, Cox, Stephanie, Kintu, Alexander, Carter, Christoph, Das, Moupali, Baeten, Jared M, Brainard, Diana M, Whitlock, Gary, Brunetta, Jason M, and Spinner, Christoph D

Published
2021
Full Text
View/download PDF

49. Incidence of Myocardial Infarction After High-Risk Vascular Operations in Adults

Author

Juo, Yen-Yi, Mantha, Aditya, Ebrahimi, Ramin, Ziaeian, Boback, and Benharash, Peyman

Subjects
Clinical Research, Cardiovascular, Heart Disease, Heart Disease - Coronary Heart Disease, Adult, Aged, Aged, 80 and over, Aorta, Female, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Peripheral Arterial Disease, Retrospective Studies, Risk Factors, United States, Vascular Surgical Procedures
Abstract

ImportanceAdvances in perioperative cardiac management and an increase in the number of endovascular procedures have made significant contributions to patients and postoperative myocardial infarction (POMI) risk following high-risk vascular procedures. Whether these changes have translated into real-world improvements in POMI incidence remain unknown.ObjectiveTo examine the temporal trends of myocardial infarction (MI) following high-risk vascular procedures.Design, setting, and participantsA retrospective cohort study was performed using data collected from January 1, 2005, to December 31, 2013, in the American College of Surgeons National Surgery Quality Improvement Program database, to which participating hospitals across the United States report their preoperative, operative, and 30-day outcome data. A total of 90 303 adults who underwent a high-risk vascular procedure-open aortic surgery or infrainguinal bypass-during the study period were identified. Patients were divided into cohorts based on their year of operation, and their baseline cardiac risk factors and incidence of POMI were compared. Cases from 2005 to 2014 in the database were eligible for inclusion if one of their Current Procedural Terminology codes matched any of the operations identified as a high-risk vascular procedure. Data analysis took place from August 1, 2016, to November 15, 2016.ExposuresThe main exposure was the year of the operation. Other variables of interest included demographics, comorbidities, and other risk factors for MI.Main outcomes and measuresPrimary outcome of interest was the incidence of POMI.ResultsOf the 90 303 patients included in the study, 22 836 (25.3%) had undergone open aortic surgery and 67 467 (74.7%) had had infrainguinal bypass. The open aortic cohort comprised 16 391 men (71.9%), had a mean (SD) age of 69.1 (11.5) years, and was predominantly white (18 440 patients [80.8%] self-identified as white race/ethnicity). The infrainguinal bypass cohort included 41 845 men (62.1%), had a mean (SD) age of 66.7 (11.7) years, and had 51 043 patients (75.7%) who self-identified as white race/ethnicity. During the study period, patients who underwent open aortic procedures were more likely to be classified as American Society of Anesthesiologists class IV (7426 patients [32.6%] vs 15 683 [23.3%] for the infrainguinal bypass cohort) or class V (1131 [5.0%] vs 206 [0.3%]; P

Published
2017

50. Evolution of Surgical Aortic Valve Replacement in the Era of Transcatheter Valve Technology

Author

Mantha, Aditya, Juo, Yen-Yi, Morchi, Ravi, Ebrahimi, Ramin, Ziaeian, Boback, Shemin, Richard J, and Benharash, Peyman

Subjects
Cost-Benefit Analysis, Health Care Costs, Heart Valve Prosthesis, Humans, Length of Stay, Multivariate Analysis, Transcatheter Aortic Valve Replacement, United States
Abstract

This cohort study analyzes the cost and stabilization of disease in patients undergoing transcatheter and surgical aortic valve replacement.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results