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Background and Aim: Stafne bone defect is a rare asymptomatic finding in radiographs. Parotid Stafne cysts are very scarce and can be located on buccal or lingual aspect of mandibular ramus. Case Report: Two well-defined radiolucent lesions were found incidentally on the panoramic radiograph of a 37 year old man. The lesions were located on the buccal side of left mandibular ramus above the lower jaw angle. CBCT showed buccal cortical plate perforation and involved more than half diameter of bone structure. No change in the size of lesion was noticed in the six-month and one-year follow-ups. Conclusion: Infrequent Stafne bone defect appearances (especially parotid related Stafne cysts) should be considered to prevent misdiagnosis. [ABSTRACT FROM AUTHOR]

Introduction: The middle mesial canal (MMC) of mandibular molars is of particular interest in endodontics due to its complexity. This study investigated the association between MMC presence in first and second mandibular molars and the radiolucency in the furcation area using cone-beam computed tomography (CBCT) scans., Materials and Methods: CBCT scans of 400 patients referred to the largest radiology center in Kerman City from January 1, 2022, to January 1, 2023, were examined. All CBCT scans were assessed for radiolucency in the furcation area and the presence of MMC. Variables, including age, gender, tooth number, and MMC presence were recorded. Chi-squared tests and logistic regression analyses were employed to compare MMC frequency and its impact on furcation radiolucency., Results: Of 201 examined teeth, 37 (18.4%) had MMC, and 23 (11.4%) exhibited furcation radiolucency. However, teeth with a mesial canal showed a higher prevalence of furcation lesions compared to those without (38% vs. 5.2%) ( P <0.001). A significant association was observed between a mesial canal and furcation radiolucency, with odds of furcation radiolucency at 12.7 after controlling for age and gender ( P <0.001)., Conclusion: A strong association exists between MMC presence in first and second mandibular molars and furcation radiolucency, unaffected by age and gender., Competing Interests: None.

Gastric ulcer (GU) is the most common health concern that occurs due to an imbalance between gastric protective mucosal and aggressive factors. Ethanol-induced GU in animal models resembles the pathophysiology of human ulcers. Natural products with fewer side effects are highly requested to attenuate their GU effects. The present study was conducted to investigate the potential protective effects of donkey milk against ethanol-induced GU in rats. The male Wistar were divided into four groups, including normal control (distilled water), donkey milk (1 cm 3 /animal) and ranitidine (200 mg/kg). Donkey milk and ranitidine were given to rats orally daily for 10 consecutive days before induction of ulcer by ethanol. After 24 h of fasting, GU was induced by oral administration of ethanol. After an hour, the rats were sacrificed, and gastric samples were taken for pathologic analysis, malondialdehyde (MDA) and glutathione (GSH) assessments. The results showed that the severity of ethanol-induced gastric damage was significantly reduced by donkey's milk pretreatment and then ranitidine. Reduction of ulcer score and MDA level, and also increasing GSH in the gastric tissue in comparison with other groups supports our results. This study described the gastroprotective and antioxidative effects of donkey milk that were determined with ulcer inhibition percentage., (© 2024 The Author(s). Veterinary Medicine and Science published by John Wiley & Sons Ltd.)

Statement of the Problem: Infection control is essential for a safe clinical environment during patients' treatment in dentistry. Transmission of the infection can occur due to contact with patients' saliva and blood in radiology clinics., Purpose: The purpose of this study was to investigate the knowledge and practice of dentists in Kerman about infection control in digital radiology., Materials and Method: This cross-sectional study was conducted on 162 dentists who worked either in private office or clinic or both. The samples were selected through simple sampling method. Data were collected through demographic data, and valid and reliable questionnaire consisted of 7 questions about knowledge and 12 questions about practice on infection control in digital radiology. Data were analyzed in SPSS 26 software using T, ANOVA, and linear regression tests. The p value was considered at 0.05% significant level., Results: 86(53.1%) of participants were men and 76 (46.9%) were female. The mean age of participants and work experience were 36.32±8.88 and 11.03±8.53 years, respectively. The mean and standard deviation of knowledge, practice, and total were 5.20±1.26, 7.98±2.00, and 13.22±2.72, respectively. There was a positive significant correlation between knowledge with age of participants ( p = 0.009). There was also a direct significant correlation between knowledge and practice with work experience ( p = 0.045 and p = 0.01 respectively)., Conclusion: Knowledge and practice of dentists in Kerman about infection control in digital radiology were good and medium respectively. However, there was a direct significant correlation between knowledge and practice of dentists. Knowledge and practice scores in dentists who worked in private office were significantly better than those who worked only in clinics., Competing Interests: The authors declare that they have no conflict of interest., (Copyright: © Journal of Dentistry.)

Background: Ferrous sulfate nanoparticles (FSNPs) were synthesized and characterized to mitigate the undesirable effects of ferrous sulfate bulk particles (FSBPs) as a supplement or fortificant in health/food industries., Methods: The toxicity of FSNPs and FSBPs was evaluated against AGS, PLC/PRF/5, and HGF1-PI 1 cell lines. Then, Wistar rats were fed three levels of FSNPs and FSBPs fortified-bread. Growth performance, hematological parameters, and histopathological changes in treated rats were assessed after 21 days., Results: High concentrations of FSNPs (3.125 and 6.25 mM) increased the necrosis of AGS cells. A low level of FSNPs (1.57 mM) did not affect the viability of cells after 72 h. Fibroblasts did not show apoptosis and necrosis after exposing 1.57 mM of FSNPs. In rats, 9 mg elemental iron of FSNPs/day enhanced hemoglobin, PCV, and ferritin values and increased the body weight gain (p < 0.05). FSNPs fortified-bread induced no clinical symptom or histopathological lesion in rats., Conclusion: FSNPs affect cells in a dose-dependent manner. The results indicate that FSNPs at the low level do not have adverse effects on normal fibroblasts and rats. Significant weight gain in rats having a low level of FSNPs compared to the FSBPs indicates the negligible toxicity of FSNPs at low concentrations., (Copyright © 2022 Elsevier GmbH. All rights reserved.)

A total of 288-day-old male broilers were allocated to six dietary treatments to evaluate the effects of zinc source and Bacillus coagulans supplements and their interaction on growth, intestinal microbial population, carcass traits and meat quality in broiler chickens. Three levels of dietary supplemental Zn source (100 mg/kg of DM diet zinc oxide, 25 and 50 mg/kg of diet zinc oxide nanoparticles (Zn-nan)) and two levels of B. coagulans (0 and 100 mg/kg of diet) were combined as a completely randomised design with a 3 × 2 factorial arrangement. B. coagulans increased the body weight gain, body weight and feed conversion ratio. The lactic acid producing bactereia of ileal were increased by B. coagulans supplementation, and its coliform count was decreased by Zn-nan in a dose-dependent manner. The B. coagulans increased the relative weights of legs and proventriculus and reduced weights of livers, abdominal fat and meat thiobarbituric acid (TBA) value. Likewise, dietary B. coagulans increased pH, yellowness and lightness values of leg muscles. Birds fed Zn-nan50 had lower liver weight, TBA and cooking loss and higher yellowness values than chicks fed ZnO-100. In conclusion, the dietary supplementation with B. coagulans improved broiler performance, microbial population and meat quality. The Zn-nan in lower dose could be a good substitution in mineral premix instead of zinc oxide. In addition, the Zn-nan improved intestinal microbial population, carcass characteristics and oxidative stability of chicken meat; however, the combination of two levels of Zn-nan with B. coagulans did not vary the measured parameters.

The thyme (Thymus vulgaris) essential oil was assessed as antibiotic growth promoter replacement in quail chick diet and in vitro test. In total, 250-d-old Japanese quail chicks (mixed sex) were allocated into 5 dietary treatments of 5 replications (6 females and 4 males in each cage with the size of 40× 90× 25 cm) under a completely randomized design. The dietary treatments were included the control diet, control diet without any additive, control diet plus 100 ppm flavophospholipol as an antibiotic growth promoter, control diet plus 200 ppm TVE, control diet plus 300 ppm TVE, and control diet plus 400 ppm T. vulgaris essential (TVE) oil. Feed intake, BW gain, feed conversion ratio (FCR), organs weight, morphology of intestine, serum lipids, and microbial population were measured on day 35. Lipid oxidation of stored muscle tissue was measured by TBARS test. GC-MS assay, DPPH method, and well diffusion method were evaluated for determination of components, antioxidant, and antimicrobial properties, respectively. FCR improved significantly in 400 ppm TVE compared with 200 and 300 ppm TVE (P < 0.05). The serum triglyceride decreased significantly in both sexes receiving 400 ppm TVE compared with control. Villi height increased significantly in duodenum accompanied by decreasing crypt dept at all TVE levels compared with control and antibiotic. The breast muscle tissue of quail fed on 300 and 400 ppm TVE reduced the rate of oxidation during refrigerated storage compared with control. Thymol was the main component (35.40%) of the thymus oil. The considerable antioxidant activity of TVE was identified by IC50 of 58.48 µg/mL. Moreover, zones of growth inhibition of Gram-positive bacteria and Escherichia coli were numerically greater in different doses of TVE than antibiotics. Therefore, The TVE is suitable alternative component for antibiotic growth promoters by dosing consideration. However, it is possible that antibiotic resistance would increase for these natural compounds along the time., (© The Author(s) 2019. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

An experiment was conducted to show the effects of different levels of pennyroyal, thyme and savory essential oils dietary supplementation on performance, organs weight, intestinal morphology, and serum lipids in quails. A total of 550 day-old Japanese quail chicks were allocated into 11 dietary treatments of 5 replications (10 birds in each cage) under a randomized experimental design. The treatments were a basal diet (Control), or 3 levels (200, 300, and 400 ppm) of thyme essential oil (TO), or 3 levels (200, 300, and 400 ppm) of savory essential oil (SO), or 3 levels (200, 300, and 400 ppm) of pennyroyal essential oil (PO) added separately to the basal diet, or also the basal diet supplemented with 100 ppm of flavophospholipol. Body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR) were measured weekly and calculated totally for 35 d. The organs weight and morphology of intestine parts of one bird from each cage were measured on 35 d. At the same day, blood samples were collected and cholesterol and triglyceride values were separately determined for male and female quails. Although the addition of different levels of essential oils in quail's diet did not affect BWG, a significant decline in FI was observed in the group supplemented with 400 ppm of TO. At the same time, FCR significantly improved (P < 0.05) in the same group as well as in the group supplemented with the antibiotic. However, the organs weight was not significantly affected by the experimental treatments. Nevertheless, villi height of duodenum, jejunum and ileum was significantly increased and crypt depth was significantly decreased in the quails fed diets supplemented with different levels of TO and SO. The values of serum triglycerides decreased in both sexes in the groups that received diets supplemented with different levels of essential oils whereas the values of cholesterol decreased only in males of the essential oils supplemented groups. From the present observations it can be concluded that thyme and savory essential oils can improve FCR by decreasing FI through boosting the absorption of nutrients in intestine. These plant essential oils can replace antibiotic growth parameters without having any adverse effect on quail's health with thyme essential oil exerting the most effective activity.

Modern challenges of food science require a new understanding of the determinants of food quality and safety. Application of advanced imaging modalities such as magnetic resonance imaging (MRI) has seen impressive successes and fast growth over the past decade. Since MRI does not have any harmful ionizing radiation, it can be considered as a magnificent tool for the quality control of food products. MRI allows the structure of foods to be imaged noninvasively and nondestructively. Magnetic resonance images can present information about several processes and material properties in foods. This review will provide an overview of the most prominent applications of MRI in food research., Competing Interests: Conflict of interests: None declared.

Introduction: The aim of this randomized clinical trial split-mouth study was to compare the postoperative pain following use of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement as pulpotomy agents in carious primary molars., Methods and Materials: Forty-seven children aged between 6-10 years old were enrolled in this study. Each child had two cariously involved primary molar in need of pulpotomy. After caries removal and preparing access cavity in one of the carious teeth, either MTA or CEM cement was randomly used as the pulpotomy agent, while the other cariously involved primary molar tooth was capped with the other material in a separate visit. After covering the radicular pulp with one of the capping materials the teeth were permanently restored with stainless steel crown (SSC). Postoperative pain was recorded by using Wong-Baker faces pain rating scale (Wong-Baker FPRS) up to seven days following the treatment. Data was analyzed using the Wilcoxon, McNemar, and chi square tests., Results: Forty-five patients fulfilled the treatment procedure and returned the Wong-Baker FPRS forms. Overall 65.6% of the patients reported pain irrespective of the pulpotomy agents used. There was no significant difference in postoperative pain between the teeth that received either MTA or CEM cement as pulpotomy agents in the first, second and the third day ( P =0.805, P =0.942, P =0.705, respectively) following the procedure. The trend of the pain scores showed decreasing manner during the study period for the teeth in either groups of MTA or CEM cement. There was no significant difference between the two groups in the number of analgesics used following the treatment ( P >0.05)., Conclusion: The findings of the present study showed that a majority of the children felt pain following pulpotomy and SSC placement; however, there was no significant difference in pain reported when either MTA or CEM cement was used as pulpotomy agents.

Objective: In modern societies, crowds and mass gatherings are recurrent. A combination of inadequate facilities and inefficient population management can lead to injury and death. Simulating people's behavior in crowds and mass gatherings can assist in the planning and management of gatherings, especially in emergency situations., Methods: We aimed to determine the crowd pattern and the critical density point in the grand bazaar of Kerman in Iran. We collected data by use of a census method with a questionnaire. To determine the critical density point, height and weight data were placed in the equation $\,s\,{\equals}\,\sqrt {{{L{\vskip -1.5pt \,\,\asterisk\,\,}M} \over {3600}}} $ and the outer body surface of all the individuals in the bazaar was calculated. The crowd was simulated by use of flow-based modeling. Flow rate was determined by using the equation (flow rate=density * speed). By use of SketchUp Pro software (version 8; Trimble, Sunnyvale, CA), the movement of each person and the general flow rate were simulated in the three-dimensional environment of Kerman bazaar., Results: Our findings showed that the population critical density point in Kerman bazaar would be 6112 people. In an accident, the critical density point in Kerman bazaar would be created in about 1 minute 10 seconds after the event., Conclusion: It seems necessary to identify and provide solutions for reducing the risk of disasters caused by overcrowding in Kerman bazaar. It is suggested that researchers conduct studies to design safe and secure emergency evacuation of Kerman bazaar as well as proper planning for better and faster access of aid squads to this location. (Disaster Med Public Health Preparedness. 2017;11:674-680).

Oral cancer is known as one of relatively common type of cancer worldwide. Despite the easy access of the oral cavity to examination, oral tumors are diagnosed in more advanced stages of the disease. Imaging techniques have been recently emerged as non-invasive approaches to detect molecular and cellular changes in living cells and organisms. These techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) could help physicians to screen patients with oral tumors particularly oral squamous cell carcinoma (OSCC) in early stage of the disease. In this review, we discuss that early detection and diagnosis of oral tumors through using more robust and precise imaging techniques and a variety of cellular/molecular biomarkers not only could lead to more effective and less aggressive form of treatment for the disease but also could improve survival rates and lower treatment costs. J. Cell. Biochem. 118: 3055-3060, 2017. © 2017 Wiley Periodicals, Inc., (© 2017 Wiley Periodicals, Inc.)

Background. Digital radiography has widespread use in endodontics. Determining a correct working length is vital for a proper endodontic therapy. The aim of this study was to compare the accuracy of conventional and digital radiographic techniques for root canal working length determination. Methods. After determining the real working lengths of 50 permanent maxillary central incisors (gold standard), the conventional (E- and F-speed films) and digital (CCD, PSP) images were obtained using the parallel technique. The mean registered working length of each modality was compared with the other and with the gold standard using one-way ANOVA at P<0.05. Results. No significant difference was found between the recorded working length values using the conventional and digital radiographic techniques (P=0.828). Conclusion. Within the limitations of this study, it was concluded that there was no difference between the measurement accuracy of CCD, PSP and conventional imaging techniques in root canal working length determination.

The microbiological and biochemical changes occurred during the fermentation of camel milk inoculated by three selected bacterial starter, were investigated as well as the sensory evaluation of the product. Milk samples were collected from camel herds of southeastern of Iran. Chr. Hansen ABT-10 starter including Lactobacillus acidophillus, Biphidobacterum biphidum and Sterptococcus thermophilus in ratio of 0.50 g per 100 mL of camel milk was added. This fermented product was examined at the 0, 3 rd , 6 th and 9 th days for microbiological, biochemical and sensory evaluations. The results showed the number of starter bacteria was maintained at least 10 6 CFU mL -1 during nine test days. It was shown that it could be used as fermented-probiotic drink. The product did not show any microbial contamination. The acidity and protein amount of produced drink showed a significant ( p < 0.05) increase in different test days. Fat, solids-not-fat and ash amount of the product showed significant differences at the ninths' test day compared to the zero test day ( p < 0.05). Organoleptic properties of product including flavor, color, odor, consistency, mouth feel and overall acceptance were significantly improved ( p < 0.05). Therefore, the produced fermented-probiotic drink, in addition to keep maintenance and increased nutritional quantity value, was accepted by consumers in terms of organoleptic properties and it could be used as a healthy and functional drink.

Objectives: New digital two-dimensional imaging systems are considered as an easily accessible modality for sinonasal evaluation. The aim of this study was to assess the diagnostic efficacy of digital Waters' and Caldwell's radiographic views for evaluation of sinonasal area., Materials and Methods: A total of 273 patients fulfilling the inclusion criteria were enrolled in this descriptive-analytical study. Complete opacification or mucosal thickening of frontal, ethmoidal and maxillary sinuses and nasal septum deviation were assessed on digital Waters and Caldwell images. Considering cone beam computed tomography (CBCT) as the gold standard, accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were obtained for the plain films., Results: The sensitivity and specificity for the diagnosis of complete opacification were 89.47% and 95.66% (for frontal sinus), 100% and 97.59% (for ethmoidal air cells), and 100% and 96.42% (for maxillary sinuses), respectively. Regarding mucosal thickening, the sensitivity and specificity were 51.43% and 90.70% (for frontal sinus), 60.84% and 84.80% (for ethmoidal air cells) and 81% and 74.74% (for maxillary sinuses), respectively. The sensitivity of Waters and Caldwell images for detecting nasal septum deviation was 84.31% and 87.25%, respectively; whereas, their specificity was 100%., Conclusions: Digital Caldwell image performs well in detecting frontal and ethmoidal opacification and nasal septum deviation. It has moderate efficacy in assessing frontal and ethmoidal mucosal thickening while it has superior performance for detection of healthy cases. Digital Waters' view is a reliable modality for maxillary sinus evaluation.

Purpose: This study was performed to compare the condylar position in patients with temporomandibular joint disorders (TMDs) and a normal group by using cone-beam computed tomography (CBCT)., Materials and Methods: In the TMD group, 25 patients (5 men and 20 women) were randomly selected among the ones suffering from TMD according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). The control group consisted of 25 patients (8 men and 17 women) with normal temporomandibular joints (TMJs) who were referred to the radiology department in order to undergo CBCT scanning for implant treatment in the posterior maxilla. Linear measurements from the superior, anterior, and posterior joint spaces between the condyle and glenoid fossa were made through defined landmarks in the sagittal view. The inclination of articular eminence was also determined., Results: The mean anterior joint space was 2.3 mm in the normal group and 2.8 mm in the TMD group, respectively. The results showed that there was a significant correlation between the superior and posterior joint spaces in both the normal and TMD groups, but it was only in the TMD group that the correlation coefficient among the dimensions of anterior and superior spaces was significant. There was a significant correlation between the inclination of articular eminence and the size of the superior and posterior spaces in the normal group., Conclusion: The average dimension of the anterior joint space was different between the two groups. CBCT could be considered a useful diagnostic imaging modality for TMD patients.

Epigenetic modifications determine phenotypic characteristics in a reversible, stable and genotype-independent manner. Epigenetic modifications mainly encompass CpG island methylation and histone modifications, both being important in the pathogenesis of malignancies. The reversibility of epigenetic phenomenon provides a suitable therapeutic option that is reactivation of epigenetically silenced tumor-suppressor genes. Inhibition of DNA methyltransferase, histone deacetylase and Aurora B kinase, individually or collectively, could feasibly prevent or reverse the impact of epigenetic silencing. MicroRNAs [miRNAs] are an important layer of epigenetic controlling of gene expression, and serve as diagnostic and prognostic biomarkers as well as treatment targets for several types of cancer. miRNAs are involved inepigenetically silencing or activation of genes, tumor suppressor genes and oncogenes, and their modulation opens new horizons for designing novel cancer therapeutic agents.

Central odontogenic fibroma (COF) is a rare benign tumor that accounts for 0.1% of all odontogenic tumors. A case of COF (simple type) of the mandible in a four-year-old boy is described in this report. The patient showed asymptomatic swelling in the right inferior border of the lower jaw for one week. A panoramic radiograph showed a poorly-defined destructive unilocular radiolucent area. Cone-beam computed tomography showed expansion and perforation of the adjacent cortical bone plates. A periosteal reaction with the Codman triangle pattern was clearly visible in the buccal cortex. Since the tumor had destroyed a considerable amount of bone, surgical resection was performed. No recurrence was noted.

The effects of essential oil (EO) of oregano and chitosan on the microbial quality and growth inhibition of Listeria monocytogenes and Escherichia coli O157:H7 in the Iranian traditional ready-to-barbecue chicken was evaluated. Thus, three groups of samples were prepared. One of them was considered to evaluate for aerobic plate count (APC), lactic acid bacteria (LAB), psychrophilic and enterobacteriacae counts and the other two groups were inoculated with E. coli O157:H7 and L. monocytogenes 4b to investigate the effect of oregano EO and chitosan on pathogenic bacteria. All groups were stored at 3, 8 and 20°C. Oregano showed antibacterial effects against APC, LAB, psychrophilics, enterobacteriacae and E. coli O157:H7, whereas, such an effect was not observed against L. monocytogenes. Chitosan individually did not show an inhibitory effect on the spoilage-inducing bacteria and E. coli, but was effective against L. monocytogenes. Using chitosan and oregano EO in combination can reduce the number of spoilage and safety indicators and also the two food-borne pathogens in ready-to-barbecue chicken meat., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Selenium compounds play a major role in Biology, where they are often associated with pronounced antioxidant activity or toxicity. Whilst most selenium compounds are not necessarily hazardous, their often selective cytotoxicity is interesting from a biochemical and pharmaceutical perspective. We have synthesized a series of amphiphilic molecules which combine a hydrophilic seleninic acid head group - which at the same time serves as thiol-specific warhead - with a hydrophobic tail. These molecules possess a surface activity similar to the one of SDS, yet their biological activity seems to exceed by far the one of a simple surfactant (e.g. SDS) or seleninic acid (e.g. phenyl seleninic acid). Such compounds effectively haemolyse Red Blood Cells and exhibit pronounced activity against Saccharomyces cerevisiae. From a chemical perspective, the seleninic warheads are likely to attack crucial cysteine proteins of the cellular thiolstat., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Effects of different medium-voltage electrical stimulation (ES) and ageing on postmortem changes in longissimus dorsi muscle of the fat-tailed sheep were studied. Fifteen male animals were divided into 5 equal groups (n= 3) including: T₁ (control, without ES), T₂ (100 V/30 s), T₃ (100 V/60 s), T₄ (150 V/30 s), and T₅ (150 V/60 s) with fixed frequency of 50 Hz. Five minutes after sticking, the carcasses were stimulated in order of the treatments. After normal processing, they were kept at 6 °C for 14 d. ES accelerated the glycolytic rate resulting in a significant fast fall in pH (P < 0.05) during the 1st 6-h postmortem (PM) with a gradual decline until 24-h PM, and a simultaneous significant reduction in adenosine triphosphate (ATP) content (P < 0.05). There was a significant (P < 0.05) decline in the total calpain activity during the 1st 6-h PM. The muscles from ES carcasses had significantly (P < 0.05) lower water holding capacity (WHC) than those from nonstimulated ones. Ageing revealed a significant (P < 0.05) effect on the reduction of WHC. No significant difference was found for the mean value of the muscle color (L*, a*, and b*) in all treatment groups during ageing (P > 0.05). The results of free amino acid (FAA) content and myofibrillar fragmentation index (MFI) revealed a significant improvement of proteolysis and tenderness by ES and ageing (P < 0.05). In the present study, higher voltage/duration (150 V/60 s) showed greater effects and significantly accelerated glycolysis, pH decline, and ATP depletion and thus decreased the time for rigor completion and improved the tenderness., (© 2011 Institute of Food Technologists®)

In a description of a historical case in 19th Century Persia, this article endeavours to show how changes in medical thought occurred. It argues that Medical Modernisation was apparent in the internal changes in traditional medicine. While cholera was frequently recorded, as an epidemic disease, over several centuries in the Persian Medical literature, why and how it became at this period, before contact with Western medicine, under close scrutiny by the traditional medicine. This new scrutiny is illustrated in the writings of Shirazi, a traditional court doctor, who endeavoured to describe cholera, diarrhoea and plague. In doing this, he introduced a significant change in the meanings of vaba and ta'un (generic terms attributed to any epidemic disease). Shirazi used them specifically to mean what we understood as cholera, for the former, and plague for the latter. The internal change in traditional medical thought, together with the awakening of socio-political consciousness regarding the spread of epidemics, were the main factors clearing the path to a natural integration of Western medicine in 19th century Iran.

The ravages wrought by epidemics in Iran as of 1821 acted as a stimulus to medical thought while the awakening of political consciousness mobilized efforts to fight contagious diseases. The combination "epidemics-politics-medicine" made nineteenth-century Persia turn to European science for help. Thus western medicine was introduced into Persia. If this introduction has been perceived by political means and epidemiological justification, the theoretical and epistemological process involved has been almost completely overlooked or misinterpreted. It is generally considered that the imported medicine swept away the local one, but this is not altogether true. It was the internal evolution of traditional medicine which paved the way for anatomoclinical medicine. This evolution comes accross clearly in the works of Shirâzi and Sâveji between 1831 and 1862, years in which epidemics struck frequently and violently. While Europeans in Iran such as Dr. Polak qualified heyzeh (a kind of severe diarrhea) a "sporadic cholera" or "autumn cholera", Shirâzi wrote three treatises to show that heyzeh was not cholera but an ordinary kind of diarrhea caused by generalized malnourishment. Shirâzi was also an innovator in the theoretical and terminological fields, doing away with the notion of vabâ which meant a putrid atmosphere. Vabâ became a physiological anomaly which took on epidemic proportions in an impure atmosphere. The modern definition of vabâ meaning cholera was therefore elaborated thanks to Shirâzi.