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4. sj-pdf-1-msj-10.1177_13524585211007086 – Supplemental material for Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica

Author

Ciotti, John R, Eby, Noah S, Brier, Matthew R, Wu, Gregory F, Chahin, Salim, Cross, Anne H, and Naismith, Robert T

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, humanities, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-msj-10.1177_13524585211007086 for Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica by John R Ciotti, Noah S Eby, Matthew R Brier, Gregory F Wu, Salim Chahin, Anne H Cross and Robert T Naismith in Multiple Sclerosis Journal

Published
2021
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6. Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica.

Author

Ciotti, John R, Eby, Noah S, Brier, Matthew R, Wu, Gregory F, Chahin, Salim, Cross, Anne H, and Naismith, Robert T

Subjects
*NEUROMYELITIS optica, *MYELIN oligodendrocyte glycoprotein, *AQUAPORINS, *MULTIPLE sclerosis, *MAGNETIC resonance imaging, *OPTIC nerve
Abstract

Background: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Central vein sign (CVS) prevalence has not yet been well-established in MOGAD. Objective: Characterize the magnetic resonance imaging (MRI) appearance and CVS prevalence of MOGAD patients in comparison to matched cohorts of MS and AQP4+ NMOSD. Methods: Clinical MRIs from 26 MOGAD patients were compared to matched cohorts of MS and AQP4+ NMOSD. Brain MRIs were assessed for involvement within predefined regions of interest. CVS was assessed by overlaying fluid-attenuated inversion recovery (FLAIR) and susceptibility-weighted sequences. Topographic analyses were performed on spinal cord and orbital MRIs when available. Results: MOGAD patients had fewer brain lesions and average CVS+ rate of 12.1%, compared to 44.4% in MS patients (p = 0.0008). MOGAD spinal cord and optic nerve involvement was lengthier than MS (5.8 vs 1.0 vertebral segments, p = 0.020; 3.0 vs 0.5 cm, p < 0.0001). MOGAD patients tended to have bilateral/anterior optic nerve pathology with perineural contrast enhancement, contrasting with posterior optic nerve involvement in NMOSD. Conclusion: CVS+ rate and longer segments of involvement in the spinal cord and optic nerve can differentiate MOGAD from MS, but do not discriminate as well between MOGAD and AQP4+ NMOSD. [ABSTRACT FROM AUTHOR]

Published
2022
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