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12 results on '"Edberg, Karl Erik"'

2. Nitric oxide 2

Author

Zobel, G., Gamillscheg, A., Urlesberger, B., Rödl, S., Dacar, D., Berger, J., Metzler, H., Beitzke, A., Rigler, B., Trop, M., Grubbauer, H. M., Goldman A. P., Tasker R. C., Hosiasson S., Henrichsen T., Macrae D. J., Jouvet, P., Treluyer, J. M., Werner, E., Hubert, P., Pfenninger, J., Bachmann, D. C. G., Wagner, B. P., Göthberg, Sylvia, Edberg, Karl Erik, Tang, Swee Fong, Holmgren, Daniel, Michelsen, Svein, Miller, Owen, Thaulow, Erik, Winberg, Per, Lönnqvist, Per-Arne, Biban P., Pettenazzo A., Trevisanuto D., Ferrarese P., and Zacchello F.

Published
1996
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4. Patient-controlled analgesia in the management of postoperative pain in children and adolescents

Author

Rugytė, Danguolė-Česlava and Edberg, Karl Erik

Subjects
617-089.5 [udc], Pain, postoperative, In infancy&childhood, Analgesia, Methods
Abstract

Objective. We aimed to evaluate the efficacy, morphine requirements and side effects in patients managed with patient-controlled analgesia postoperatively. Methods. Eighty-seven patients, 7 to 22 (median 14) years of age, after orthopedic, abdominal or thoracic surgery, were studied retrospectively. All patients had a preset standard continuous morphine infusion of 10 μg/kg/h, 20 μg/kg bolus dose, 8 min lock-out time and 100 μg/kg/h maximal dose. All patients were additionally treated with non-steroidal anti-inflammatory drugs. Respiratory rate, pain intensity, morphine requirements and nausea/ vomiting were evaluated every 3 hours. Pain was assessed using 6-point scale (1-no pain, 6-the worst pain). Results. Median time for pain management was 51 h. Median (range) used dose of morphine was 19.9 (4.9–75.2) μg/kg/h. Sixty-one percent of the patients had a mean pain score of 1 or 2, 26% – 3, 13% – 4 or 5. Nausea/ vomiting occurred in 78% of cases. Respiratory rate less than 10 breaths per min was observed in 5.7% of patients. No patient required opioid antagonist to treat respiratory depression. Conclusions. In the majority of patients patient-controlled analgesia was effective and used doses of morphine were low. Though nausea/ vomiting was the most common side effect, decreased respiratory rate was observed in some patients. Regular patient evaluation for vital signs and side effects is recommended.

Published
2002

10. Inhaled nitric oxide to newborns and infants after congenital heart surgery on cardiopulmonary bypass. A dose-response study.

Author

Göthberg, Sylvia, Edberg, Karl Erik, Göthberg, S, and Edberg, K E

Subjects
*NITRIC oxide, *PULMONARY artery, *DOSE-response relationship in biochemistry, *CARDIOPULMONARY bypass, *COMPARATIVE studies, *CONGENITAL heart disease, *DOSE-effect relationship in pharmacology, *RESEARCH methodology, *MEDICAL cooperation, *POSTOPERATIVE care, *PULMONARY hypertension, *RESEARCH, *SURGICAL complications, *EVALUATION research, *INHALATION administration
Abstract

Twelve patients (median age 3.8 months) with pulmonary hypertension in the postoperative period after congenital heart surgery on cardiopulmonary bypass were given inhaled nitric oxide. Effects on cardiovascular and respiratory systems were measured. Mean pulmonary artery pressure decreased from 33+/-2 to 28+/-2 mmHg (p < 0.001) and arterial oxygen tension increased from 13.3+/-2.3 to 16.7+/-2.7 kPa (p < 0.05). The mean change in arterial oxygen tension in percent was 29.8+/-6.3% (p < 0.05). The response was significant only in the first step from 0 to 3 or 5 ppm with no further significant changes in mean pulmonary artery pressure or oxygenation at higher doses. The decrease in mean pulmonary artery pressure was concomitant with a significant increase in arterial oxygen tension. No dose-response relationship was found with increasing doses to 80 ppm. [ABSTRACT FROM AUTHOR]

Published
2000
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11. [Debut symptoms in staphylococcal scalded skin syndrome difficult to interpret. The condition can be life-threatening in spite of quick and adequate treatment].

Author

Broberg A, Edberg KE, Hallberg K, Eriksson M, and Wahlgren CF

Subjects
Analgesics administration & dosage, Anti-Bacterial Agents administration & dosage, Child, Preschool, Disease Progression, Female, Fluid Therapy, Humans, Infant, Infant, Newborn, Intensive Care, Neonatal, Prognosis, Staphylococcal Scalded Skin Syndrome diagnosis, Staphylococcal Scalded Skin Syndrome drug therapy, Staphylococcal Scalded Skin Syndrome pathology
Published
2008

12. [Patient-controlled analgesia in the treatment of postoperative pain in children and adolescents].

Author

Rugyte D and Edberg KE

Subjects
Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Child, Data Interpretation, Statistical, Humans, Morphine adverse effects, Pain Measurement, Pain, Postoperative diagnosis, Retrospective Studies, Time Factors, Analgesia, Patient-Controlled, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Morphine administration & dosage, Pain, Postoperative drug therapy
Abstract

Objective: We aimed to evaluate the efficacy, morphine requirements and side effects in patients managed with patient-controlled analgesia postoperatively., Methods: Eighty-seven patients, 7 to 22 (median 14) years of age, after orthopedic, abdominal or thoracic surgery, were studied retrospectively. All patients had a preset standard continuous morphine infusion of 10 micrograms/kg/h, 20 micrograms/kg bolus dose, 8 min lock-out time and 100 micrograms/kg/h maximal dose. All patients were additionally treated with non-steroidal anti-inflammatory drugs. Respiratory rate, pain intensity, morphine requirements and nausea/vomiting were evaluated every 3 hours. Pain was assessed using 6-point scale (1-no pain, 6-the worst pain)., Results: Median time for pain management was 51 h. Median (range) used dose of morphine was 19.9 (4.9-75.2) micrograms/kg/h. Sixty-one percent of the patients had a mean pain score of 1 or 2, 26%--3, 13%--4 or 5. Nausea/vomiting occurred in 78% of cases. Respiratory rate less than 10 breaths per min was observed in 5.7% of patients. No patient required opioid antagonist to treat respiratory depression., Conclusions: In the majority of patients patient-controlled analgesia was effective and used doses of morphine were low. Though nausea/vomiting was the most common side effect, decreased respiratory rate was observed in some patients. Regular patient evaluation for vital signs and side effects is recommended.

Published
2002

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