Search

Your search keyword '"Edelungudi I. Edagha"' showing total 4 results
Start Over Author "Edelungudi I. Edagha"
4 results on '"Edelungudi I. Edagha"'

1. Ocimum gratissimum attenuates diabetes-induced biochemical and histomorphological gonado-alterations

Author

Kiki A. Inyang, Innocent A. Edagha, Edet O. Akpanyung, Edelungudi I. Edagha, Ikanna E. Asuquo, and David O. Edem

Subjects
Ocimum gratissimum, Metformin, Vildagliptin, Gonado-toxicity, Seminal analysis, Science
Abstract

There is a nexus between diabetes mellitus (DM) and sexual dysfunction in males. Ocimum gratissimum (OG) or scent leaf is commonly used to manage DM in traditional medicine. This study investigated testicular biochemical and histological alterations in normal and type 2 DM in vivo models, following administration of ethanol leaf extract of OG compared with standard hypoglycemic drugs Galvus (vildagliptin) and GalvusMet (vildagliptin-with-metformin). Type 2 DM was induced in Wistar rats using high fat diet and streptozotocin (50 mgkg−1 body weight [bw]). Animals were assigned into 8 groups of 10 rats each. Groups 1 and 2 served as normal and diabetic controls respectively, which received 2 mL of 10% Tween 80 kg−1bw. Groups 3 and 4 (normoglycemic) received OG 122.47 and 244.94 mgkg−1bw respectively, which were also received by diabetic groups 5 and 6 in that order. Diabetic groups 7 and 8 received Galvus and GalvusMet (0.714 and 15 mgkg−1bw) respectively. Leaf extracts generally increased levels of follicle stimulating hormone of test rats when compared with controls. Testicular superoxide dismutase and glutathione concentrations of non-diabetic rats were significantly increased (p < 0.05) in comparison with diabetics. Malondialdehyde concentrations of extract-administered diabetic groups were lower than those of diabetics treated with standard drugs. Active sperm counts and motility increased in diabetic groups given drug/extract, when compared with diabetic control. Testicular histology showed severe spermatogenic cell distortions in diabetic control, which were ameliorated by drug or extract. OG extract stimulates spermatogenesis and ameliorates germinal epithelial distortions caused by DM.

Published
2022
Full Text
View/download PDF

4. Investigating the comparative effects of six artemisinin-based combination therapies on Plasmodium-induced hepatorenal toxicity

Author

Joy V Bassey, Rose F Obeten, Anthony S Okon, Titus P Nyong, Anthony S Akpan, Innocent A. Edagha, Arit J. Ekpo, Edelungudi I. Edagha, and Blessing A Ating

Subjects
kidney, Kidney, mice, Inhalation, biology, business.industry, malaria, General Medicine, Parasitemia, Pharmacology, liver, medicine.disease, biology.organism_classification, Regimen, medicine.anatomical_structure, Artemisinin-based combination therapies, parasitic diseases, Toxicity, medicine, Original Article, Plasmodium berghei, Artemisinin, business, Malaria, medicine.drug
Abstract

Background: Too many artemisinin-based combination therapies (ACTs) are available, thus creating a dilemma on the most preferred for the treatment of malaria. Aim: We compared the effect of six ACTs in mitigating Plasmodium-induced hepatorenal toxicity in experimental malaria. Materials and Methods: Forty adult male Swiss mice allotted into eight groups: Group 1 (normal control [NC] uninfected and untreated), Group 2 (parasitized nontreated – [PNT]), and Groups 3–8 received Plasmodium berghei inoculum. After 72 h, the initial parasitemia was established. Groups 3–8 were administered oral therapeutic doses of artesunate-amodiaquine (AA), artesunate-mefloquine (AM), artesunate-sulfadoxine-pyrimethamine (ASP), artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL) per kg bodyweight, respectively, as standard regimen, and final parasitemia determined. Animals were euthanized via chloroform inhalation and blood collected for hepatorenal analysis. Liver and kidney were dissected out for histology. Results: Parasitemia was significantly (P < 0.05) decreased in tests compared to PNT, except in ASP group. Liver enzymes were significantly (P < 0.05) increased in PNT compared to tests and NC. Hyperplastic cells and portal tract inflammation were prominent in ASP group, but mild to moderate in other treated groups. Urea-creatinine were significantly (P < 0.05) increased in PNT compared to treated groups. The Na+ and Cl− were significantly (P < 0.05) reduced in PNT, with significantly (P < 0.05) increased K+ compared to NC and treated groups. Glomerulonephritis and glomerulus splitting was observed in PNT, while moderate distortions were observed in treated groups. The AA and AM groups had good kidney histoarchitecture. Conclusion: Parasitemia decreased in all the treatment groups except in PNT and ASP groups which had severe hepatorenal distortions. Hepatorenal histoarchitecture were mildly distorted in the AA, AM and AL-administered groups with lower hepatorenal indices comparable to NC. The least elevated liver enzymes were in AA and AM. In decreasing order ASP > DP > AL > AP > AM > AA.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results