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4. Genetic mapping of quantitative trait loci for growth and fatness in pigs

Author

Andersson, Leif, Haley, Chris S., Ellegren, Hans, Knott, Sara A., Johansson, Maria, Andersson, Kjell, Andersson-Eklund, Lena, Edfors-Lilja, Inger, Fredholm, Merete, Hansson, Ingemar, Hakansson, Jan, and Lundstrom, Kerstin

Subjects
Obesity -- Genetic aspects -- Research, Swine -- Genetic aspects -- Research, Genetics -- Genetic aspects -- Research, Chromosome mapping -- Research -- Genetic aspects, Science and technology, Research, Genetic aspects
Abstract

The European wild boar was crossed with the domesticated Large White to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity., Quantitative genetic variation is the major determinant of intra- and interpopulation differences for many traits of biological, medical and agricultural significance. Quantitative (or polygenic) inheritance implies that variation in the [...]

Published
1994

5. Case History in Animal Improvement

Author

Andersson, Kjell, primary, Hansson, Ingemar, additional, Knott, Sara, additional, Johansson Moller, Maria, additional, Haley, Chris, additional, Edfors-Lilja, Inger, additional, Lundstr m, Kerstin, additional, Ellegren, Hans, additional, Marklund, Lena, additional, Andersson-Eklund, Lena, additional, and Andersson, Leif, additional

Published
1997
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9. Genetic analysis of porcine TLR genes

Author

Bergman, Ingrid-Maria, Johansson, Amelie, Fossum, Caroline, Andersson, Leif, Edfors-Lilja, Inger, Bergman, Ingrid-Maria, Johansson, Amelie, Fossum, Caroline, Andersson, Leif, and Edfors-Lilja, Inger

Abstract

Nummer

Published
2007

10. Refined linkage mapping of the Escherichia coli F4ac receptor gene on pig chromosome 13

Author

Joller, D, Jorgensen, Claus B, Bertschinger, HU, Burgi, E, Stannarius, C, Mortensen, PK, Cirera, S, Archibald, Alan, Genini, S, Edfors-Lilja, Inger, Andersson, Leif, Fredholm, Merete, Vögli, Peter, Joller, D, Jorgensen, Claus B, Bertschinger, HU, Burgi, E, Stannarius, C, Mortensen, PK, Cirera, S, Archibald, Alan, Genini, S, Edfors-Lilja, Inger, Andersson, Leif, Fredholm, Merete, and Vögli, Peter

Abstract

Nummer

Published
2006

14. Marker-assisted selection on E. coli F4ab/ac resistance and the effect on neonatal survival in piglets

Author

Jørgensen, Claus Bøttcher, Anderson, Susan I., Cirera, Susanna, Archibald, Alan, Raudsepp, Terje, Chowdhary, Bhanu, Edfors-Lilja, Inger, Andersson, Leif, Nielsen, Bjarne, Johannsen, Maria N., Fredholm, Merete, Jørgensen, Claus Bøttcher, Anderson, Susan I., Cirera, Susanna, Archibald, Alan, Raudsepp, Terje, Chowdhary, Bhanu, Edfors-Lilja, Inger, Andersson, Leif, Nielsen, Bjarne, Johannsen, Maria N., and Fredholm, Merete

Abstract

Enterotoxigenic Escherichia coli (ETEC) that express the F4ab or F4ac fimbriae (formerly known as K88ab/ac) are major causes of diarrhea and death in neonatal and young pigs. A locus controlling susceptibility towards ETEC F4ab/ac has previously been mapped to pig chromosome 13q41. A number of studies indicate that candidate genes for this trait could either be transferrin-like-genes or mucin-like sialoglycoproteins. Deductions based on linkage and comparative mapping data point to mucin 4 (MUC4) as a likely candidate. Incidentally, the gene lies in one of the candidate regions on Hsap3 (viz., Hsap3q29). We isolated pig BAC clones containing MUC4, and mapped the BACs by FISH to SSC13q41. FISH mapping on interphase nuclei positioned MUC4 between microsatellite markers Sw207 and S0283 while radiation hybrid mapping positioned it between SST and SWR2189. Initial screening for polymorphism in the gene revealed a SNP in intron 7 that shows complete co-segregation with ETEC F4ab/ac susceptibility in a Wild boar/Large White intercross. We report on the genomic characterization of the porcine mucin 4 gene spanning 25 exons and more than 31 kb. Comparison between the porcine mucin 4 gene and the human ortholog shows conservation between 58% and 89% on the nucleotide level of the different exons. Highly conserved non-protein coding sequences are also evident from the comparison. Alignment between porcine and murine MUC4 shows less conservation than the pig-human comparison. In addition to the genomic sequence of pig mucin 4 we also report on more than 15 SNPs discovered in the porcine MUC4 sequence. Collaboration with the Danish Slaughterhouses on genotyping of the intron 7 SNP of Mucin 4 in 6.373 breeding boars (3.432 Landrace and 2.941 Large White) and analysis of their offspring has revealed data of relevance to neonatal survival. Analysis on offspring from 6.373 animals show a highly significant (P < 0.0001 for Landrace and P = 0.0003 for Large White) positive correlat

Published
2005

16. Mucin 4: A candidate gene for susceptibility towards E. coli F4ab/ac diarrhea in the pig

Author

Jorgensen, Claus B, Andersson, SI, Cirera, S, Archibald, Alan, Raudsepp, Terje, Chowdhary, Bhanu, Edfors-Lilja, Inger, Andersson, Leif, Fredholm, Merete, Jorgensen, Claus B, Andersson, SI, Cirera, S, Archibald, Alan, Raudsepp, Terje, Chowdhary, Bhanu, Edfors-Lilja, Inger, Andersson, Leif, and Fredholm, Merete

Abstract

Nummer

Published
2004

25. Molecular basis for the dominant white phenotype in the domestic pig

Author

Marklund, Stefan, Kijas, Jim, Rodriguez-Martinez, Heriberto, Rönnstrand, Lars, Funa, K, Moller, Maria, Lange, D, Edfors-Lilja, Inger, Andersson, Leif, Marklund, Stefan, Kijas, Jim, Rodriguez-Martinez, Heriberto, Rönnstrand, Lars, Funa, K, Moller, Maria, Lange, D, Edfors-Lilja, Inger, and Andersson, Leif

Published
1998

27. Case history in animal improvement: Genetic mapping of QTLs for growth and fatness in the pig

Author

Andersson, Leif, Andersson, Kjell, Andersson-Eklund, Lena, Edfors-Lilja, Inger, Ellegren, Hans, Haley, CS, Hansson, I, Johansson Moller, Maria, Knott, SA, Lundström, Kerstin, Marklund, Lena, Andersson, Leif, Andersson, Kjell, Andersson-Eklund, Lena, Edfors-Lilja, Inger, Ellegren, Hans, Haley, CS, Hansson, I, Johansson Moller, Maria, Knott, SA, Lundström, Kerstin, and Marklund, Lena

Abstract

Nummer

Published
1997

33. Assignement of 20 microsatellite markers to the porcine linkage map

Author

Ellegren, Hans, Johansson, Maria, Chowdhary, Bhanu P, Marklund, Stefan, Ruyter, D, Marklund, Lena, Bräuner-Nielsen, P, Edfors-Lilja, Inger, Gustafsson, Ingemar, Juneja, R Kumar, Andersson, Leif, Ellegren, Hans, Johansson, Maria, Chowdhary, Bhanu P, Marklund, Stefan, Ruyter, D, Marklund, Lena, Bräuner-Nielsen, P, Edfors-Lilja, Inger, Gustafsson, Ingemar, Juneja, R Kumar, and Andersson, Leif

Published
1993

35. Genetic variation in Con A induced interleukin 2 production by porcine blood mononuclear cells

Author

Edfors-Lilja, Inger, Bergström, Malin, Gustafsson, Ulla, Magnusson, Ulf, Fossum, Caroline, Edfors-Lilja, Inger, Bergström, Malin, Gustafsson, Ulla, Magnusson, Ulf, and Fossum, Caroline

Abstract

Genetic variation in concanavalin A (Con A)-induced proliferation and interleukin 2 (IL-2) production by peripheral blood mononuclear cells (PBMC) was studied in blood collected from 96 piglets, a aged 7 weeks. The piglets were the offspring of seven sires and 24 dams. Pronounced differences between litters from various dams were observed in the immune parameters measured. Also, large individual differences in the magnitudes of Con A-induced proliferation and IL-2 production were seen for PBMC collected from individual pigs within each litter. Both the time course and magnitude of IL-2 activity showed genetic variation, as results from the offspring of the seven sires differed significantly. However, only the time course, not the magnitude, of proliferation differed among the offspring groups. It was possible to establish a rank order for the sires based on the IL-2 production of PBMC by their offspring. As IL-2 has a key role in regulating the immune response, mitogen-induced IL-2 activity seems to be a good candidate as a general marker for cell-mediated immunity in pigs.

Published
1991
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42. Assignment of 20 Microsatellite Markers to the Porcine Linkage Map

Author

Ellegren, Hans, primary, Johansson, Maria, additional, Chowdhary, Bhanu P., additional, Marklund, Stefan, additional, Ruyter, Dirk, additional, Marklund, Lena, additional, Bräuner-Nielsen, Paul, additional, Edfors-Lilja, Inger, additional, Gustavsson, Ingemar, additional, Juneja, R.Kumar, additional, and Andersson, Leif, additional

Published
1993
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