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1. Phase angle as a prognostic indicator of surgical outcomes in patients with gastrointestinal cancer

Author

Gulin Jana, Ipavic Ester, Mastnak Denis Mlakar, Brecelj Erik, Edhemovic Ibrahim, and Kozjek Nada Rotovnik

Subjects
phase angle, colorectal cancer, postoperative complications, malnutrition, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

In patients with gastrointestinal cancer with planned elective surgery, malnutrition increases the risk of adverse outcomes in the postoperative period. The phase angle, measured by the bioelectrical impedance analysis is an indicator of the metabolic and functional status of the patient. It may be an important prognostic indicator for the clinical outcome of post-surgical treatment in patients with gastrointestinal cancer.

Published
2023
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2. Locoregional Failure During and After Short-course Radiotherapy Followed by Chemotherapy and Surgery Compared With Long-course Chemoradiotherapy and Surgery: A 5-Year Follow-up of the RAPIDO Trial

Author

Dijkstra, Esmée A., Nilsson, Per J., Hospers, Geke A.P., Bahadoer, Renu R., Meershoek-Klein Kranenbarg, Elma, Roodvoets, Annet G.H., Putter, Hein, Berglund, Åke, Cervantes, Andrés, Crolla, Rogier M.P.H., Hendriks, Mathijs P., Capdevila, Jaume, Edhemovic, Ibrahim, Marijnen, Corrie A.M., van de Velde, Cornelis J.H., Glimelius, Bengt, and van Etten, Boudewijn

Published
2023
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3. Locoregional Failure During and After Short-course Radiotherapy followed by Chemotherapy and Surgery Compared to Long-course Chemoradiotherapy and Surgery – A Five-year Follow-up of the RAPIDO Trial

Author

Dijkstra, Esmée A., Nilsson, Per J., Hospers, Geke A.P., Bahadoer, Renu R., Meershoek-Klein Kranenbarg, Elma, Roodvoets, Annet G.H., Putter, Hein, Berglund, Åke, Cervantes, Andrés, Crolla, Rogier M.P.H., Hendriks, Mathijs P., Capdevila, Jaume, Edhemovic, Ibrahim, Marijnen, Corrie A.M., van de Velde, Cornelis J.H., Glimelius, Bengt, and van Etten, Boudewijn

Published
2023
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5. Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer – Results of the international randomized RAPIDO-trial

Author

van der Valk, Maxime J.M., Marijnen, Corrie A.M., van Etten, Boudewijn, Dijkstra, Esmée A., Hilling, Denise E., Kranenbarg, Elma Meershoek-Klein, Putter, Hein, Roodvoets, Annet G.H., Bahadoer, Renu R., Fokstuen, Tone, ten Tije, Albert Jan, Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andrès M.R., de Groot, Derk Jan A., Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J.H., and Hospers, Geke A.P.

Published
2020
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6. Radiological findings of porcine liver after electrochemotherapy with bleomycin

Author

Brloznik Maja, Boc Nina, Sersa Gregor, Zmuc Jan, Gasljevic Gorana, Seliskar Alenka, Dezman Rok, Edhemovic Ibrahim, Milevoj Nina, Plavec Tanja, Erjavec Vladimira, Pavlin Darja, Bosnjak Masa, Brecelj Erik, Tratar Ursa Lampreht, Kos Bor, Izlakar Jani, Stukelj Marina, Miklavcic Damijan, and Cemazar Maja

Subjects
electrochemotherapy, pig, liver, hepatic vessels, ultrasound, computed tomography, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Radiologic findings after electrochemotherapy of large hepatic blood vessels and healthy hepatic parenchyma have not yet been described.

Published
2019
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7. Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy

Author

Boc Nina, Edhemovic Ibrahim, Kos Bor, Music Maja M., Brecelj Erik, Trotovsek Blaz, Bosnjak Masa, Djokic Mihajlo, Miklavcic Damijan, Cemazar Maja, and Sersa Gregor

Subjects
electrochemotherapy, ultrasound, treatment plan, colorectal liver metastases, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy of liver tumors to determine the actual ablation zone and to verify the coverage of the treated tumor with a sufficiently strong electric field for effective electrochemotherapy.

Published
2018
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8. Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer - long-term results of phase II OIGIT-01 Trial

Author

Golo Danijela, But-Hadzic Jasna, Anderluh Franc, Brecelj Erik, Edhemovic Ibrahim, Jeromen Ana, Omejc Mirko, Oblak Irena, Secerov-Ermenc Ajra, and Velenik Vaneja

Subjects
rectal cancer, neoadjuvant chemotherapy, preoperative chemoradiotherapy, pathologic complete response, total neoadjuvant therapy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The purpose of the study was to improve treatment efficacy for locally advanced rectal cancer (LARC) by shifting half of adjuvant chemotherapy preoperatively to one induction and two consolidation cycles.

Published
2018
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10. The influence of the distal resection margin length on local recurrence and long- term survival in patients with rectal cancer after chemoradiotherapy and sphincter- preserving rectal resection

Author

Grosek Jan, Velenik Vaneja, Edhemovic Ibrahim, and Omejc Mirko

Subjects
rectal cancer, distal resection margin, chemoradiotherapy, local recurrence, survival, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Low recurrence rates and long term survival are the main therapeutic goals of rectal cancer surgery. Complete, margin- negative resection confers the greatest chance for a cure. The aim of our study was to determine whether the length of the distal resection margin was associated with local recurrence rate and long- term survival.

Published
2017
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11. The First Clinical Experience with Electrochemotherapy of the Colorectal Liver Metastases

Author

Edhemovic, Ibrahim, Brecelj, Erik, Gasljevic, Gorana, Music, Maja Marolt, Gorjup, Vojka, Mali, Barbara, Jarm, Tomaz, Kos, Bor, Pavliha, Denis, Kuzmanov, Biljana Grcar, Cemazar, Maja, Snoj, Marko, Miklavčič, Damijan, Gadzijev, Eldar M., Sersa, Gregor, MAGJAREVIC, Ratko, Editor-in-chief, Ładyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, and Vasic, Darko, editor

Published
2015
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13. Locoregional Failure During and After Short-course Radiotherapy Followed by Chemotherapy and Surgery Compared With Long-course Chemoradiotherapy and Surgery

Author

Dijkstra, Esmee A., Nilsson, Per J., Hospers, Geke A. P., Bahadoer, Renu R., Meershoek-Klein Kranenbarg, Elma, Roodvoets, Annet G. H., Putter, Hein, Berglund, Åke, Cervantes, Andres, Crolla, Rogier M. P. H., Hendriks, Mathijs P., Capdevila, Jaume, Edhemovic, Ibrahim, Marijnen, Corrie A. M., van de Velde, Cornelis J. H., Glimelius, Bengt, van Etten, Boudewijn, Dijkstra, Esmee A., Nilsson, Per J., Hospers, Geke A. P., Bahadoer, Renu R., Meershoek-Klein Kranenbarg, Elma, Roodvoets, Annet G. H., Putter, Hein, Berglund, Åke, Cervantes, Andres, Crolla, Rogier M. P. H., Hendriks, Mathijs P., Capdevila, Jaume, Edhemovic, Ibrahim, Marijnen, Corrie A. M., van de Velde, Cornelis J. H., Glimelius, Bengt, and van Etten, Boudewijn

Abstract

Objective:To analyze risk and patterns of locoregional failure (LRF) in patients of the RAPIDO trial at 5 years.Background:Multimodality treatment improves local control in rectal cancer. Total neoadjuvant treatment (TNT) aims to improve systemic control while local control is maintained. At 3 years, LRF rate was comparable between TNT and chemoradiotherapy in the RAPIDO trial. Methods:A total of 920 patients were randomized between an experimental (EXP, short-course radiotherapy, chemotherapy, and surgery) and a standard-care group (STD, chemoradiotherapy, surgery, and optional postoperative chemotherapy). LRFs, including early LRF (no resection except for organ preservation/R2 resection) and locoregional recurrence (LRR) after an R0/R1 resection, were analyzed. Results:Totally, 460 EXP and 446 STD patients were eligible. At 5.6 years (median follow-up), LRF was detected in 54/460 (12%) and 36/446 (8%) patients in the EXP and STD groups, respectively (P=0.07), in which EXP patients were more often treated with 3-dimensional-conformed radiotherapy (P=0.029). In the EXP group, LRR was detected more often [44/431 (10%) vs. 26/428 (6%); P=0.027], with more often a breached mesorectum (9/44 (21%) vs. 1/26 (4); P=0.048). The EXP treatment, enlarged lateral lymph nodes, positive circumferential resection margin, tumor deposits, and node positivity at pathology were the significant predictors for developing LRR. Location of the LRRs was similar between groups. Overall survival after LRF was comparable [hazard ratio: 0.76 (95% CI, 0.46-1.26); P=0.29]. Conclusions:The EXP treatment was associated with an increased risk of LRR, whereas the reduction in disease-related treatment failure and distant metastases remained after 5 years. Further refinement of the TNT in rectal cancer is mandated.

Published
2023
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15. The ESSO core curriculum committee update on surgical oncology

Author

van der Hage, Jos, primary, Sandrucci, Sergio, additional, Audisio, Riccardo, additional, Wyld, Lynda, additional, Søreide, Kjetil, additional, Amaral, Teresa, additional, Bahadoer, Viren, additional, Beets, Geerard, additional, Benstead, Kim, additional, Berge Nilsen, Elisabeth, additional, Bol, Kalijn, additional, Brandl, Andreas, additional, Braun, Jerry, additional, Cufer, Tanja, additional, Dopazo, Cristina, additional, Edhemovic, Ibrahim, additional, Eriksen, Jesper Grau, additional, Fiore, Marco, additional, van Ginhoven, Tessa, additional, Gonzalez-Moreno, Santiago, additional, van der Hage, Jos, additional, Hutteman, Merlijn, additional, Masannat, Yazan, additional, Onesti, Elisa Concetta, additional, Rau, Beate, additional, De Reijke, Theo, additional, Rubio, Isabel, additional, Ruurda, Jelle, additional, Soreide, Kjetil, additional, Stattner, Stefan, additional, Trapani, Dario, additional, D'Ugo, Domenico, additional, Vriens, Menno, additional, and Zahl Eriksson, Ane Gerda, additional

Published
2021
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17. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO) : a randomised, open-label, phase 3 trial

Author

Bahadoer, Renu R., Dijkstra, Esmee A., van Etten, Boudewijn, Marijnen, Corrie A. M., Putter, Hein, Kranenbarg, Elma Meershoek-Klein, Roodvoets, Annet G. H., Nagtegaal, Iris D., Beets-Tan, Regina G. H., Blomqvist, Lennart K., Fokstuen, Tone, ten Tije, Albert J., Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andres, Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J. H., Hospers, Geke A. P., Bahadoer, Renu R., Dijkstra, Esmee A., van Etten, Boudewijn, Marijnen, Corrie A. M., Putter, Hein, Kranenbarg, Elma Meershoek-Klein, Roodvoets, Annet G. H., Nagtegaal, Iris D., Beets-Tan, Regina G. H., Blomqvist, Lennart K., Fokstuen, Tone, ten Tije, Albert J., Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andres, Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J. H., and Hospers, Geke A. P.

Abstract

Background Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation (RAPIDO) trial aimed to reduce distant metastases without compromising locoregional control. Methods In this multicentre, open-label, randomised, controlled, phase 3 trial, participants were recruited from 54 centres in the Netherlands, Sweden, Spain, Slovenia, Denmark, Norway, and the USA. Patients were eligible if they were aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, had a biopsy-proven, newly diagnosed, primary, locally advanced rectal adenocardnoma, which was classified as high risk on pelvic MRI (with at least one of the following criteria: clinical tumour [cT] stage cT4a or cT4b, extramural vascular invasion, clinical nodal [cN] stage cN2, involved mesorectal fascia, or enlarged lateral lymph nodes), were mentally and physically fit for chemotherapy, and could be assessed for staging within S weeks before randomisation. Eligible participants were randomly assigned (1:1), using a management system with a randomly varying block design (each block size randomly chosen to contain two to four allocations), stratified by centre, ECOG performance status, cT stage, and cN stage, to either the experimental or standard of care group. All investigators remained masked for the primary endpoint until a prespecified number of events was reached. Patients allocated to the experimental treatment group received short-course radiotherapy (5 x 5 Gy over a maximum of 8 days) followed by six cycles of CAPDX chemotherapy (capecitabine 1000 mg/m(2) orally twice daily on days 1-14, oxaliplatin 130 mg/m(2) intravenously on day 1, and a chemotherapy-free interval between days 15-21) or nine cycles of FOLFOX4 (oxaliplatin 85 mg/m(2) intravenously on day 1, leucovorin [folinic acid] 200

Published
2021
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18. The ESSO core curriculum committee update on surgical oncology

Author

van der Hage, Jos, Sandrucci, Sergio, Audisio, Riccardo, Wyld, Lynda, Søreide, Kjetil, Amaral, Teresa, Bahadoer, Viren, Beets, Geerard, Benstead, Kim, Berge Nilsen, Elisabeth, Bol, Kalijn, Brandl, Andreas, Braun, Jerry, Cufer, Tanja, Dopazo, Cristina, Edhemovic, Ibrahim, Eriksen, Jesper Grau, Fiore, Marco, van Ginhoven, Tessa, Gonzalez-Moreno, Santiago, Hutteman, Merlijn, Masannat, Yazan, Onesti, Elisa Concetta, Rau, Beate, De Reijke, Theo, Rubio, Isabel, Ruurda, Jelle, Soreide, Kjetil, Stattner, Stefan, Trapani, Dario, D'Ugo, Domenico, Vriens, Menno, Zahl Eriksson, Ane Gerda, van der Hage, Jos, Sandrucci, Sergio, Audisio, Riccardo, Wyld, Lynda, Søreide, Kjetil, Amaral, Teresa, Bahadoer, Viren, Beets, Geerard, Benstead, Kim, Berge Nilsen, Elisabeth, Bol, Kalijn, Brandl, Andreas, Braun, Jerry, Cufer, Tanja, Dopazo, Cristina, Edhemovic, Ibrahim, Eriksen, Jesper Grau, Fiore, Marco, van Ginhoven, Tessa, Gonzalez-Moreno, Santiago, Hutteman, Merlijn, Masannat, Yazan, Onesti, Elisa Concetta, Rau, Beate, De Reijke, Theo, Rubio, Isabel, Ruurda, Jelle, Soreide, Kjetil, Stattner, Stefan, Trapani, Dario, D'Ugo, Domenico, Vriens, Menno, and Zahl Eriksson, Ane Gerda

Abstract

INTRODUCTION: Surgical oncology is a defined specialty within the European Board of Surgery within the European Union of Medical Specialists (UEMS). Variation in training and specialization still occurs across Europe. There is a need to align the core knowledge needed to fulfil the criteria across subspecialities in surgical oncology.MATERIAL AND METHODS: The core curriculum, established in 2013, was developed with contributions from expert advisors from within the European Society of Surgical Oncology (ESSO), European Society for Radiotherapy and Oncology (ESTRO) and European Society of Medical Oncology (ESMO) and related subspeciality experts.RESULTS: The current version reiterates and updates the core curriculum structure needed for current and future candidates who plans to train for and eventually sit the European fellowship exam for the European Board of Surgery in Surgical Oncology. The content included is not intended to be exhaustive but, rather to give the candidate an idea of expectations and areas for in depth study, in addition to the practical requirements. The five elements included are: Basic principles of oncology; Disease site specific oncology; Generic clinical skills; Training recommendations, and, lastly; Eligibility for the EBSQ exam in Surgical Oncology.CONCLUSIONS: As evidence-based care for cancer patients evolves through research into basic science, translational research and clinical trials, the core curriculum will evolve, mature and adapt to deliver continual improvements in cancer outcomes for patients.

Published
2021

20. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Author

Bahadoer, Renu R, primary, Dijkstra, Esmée A, additional, van Etten, Boudewijn, additional, Marijnen, Corrie A M, additional, Putter, Hein, additional, Kranenbarg, Elma Meershoek-Klein, additional, Roodvoets, Annet G H, additional, Nagtegaal, Iris D, additional, Beets-Tan, Regina G H, additional, Blomqvist, Lennart K, additional, Fokstuen, Tone, additional, ten Tije, Albert J, additional, Capdevila, Jaume, additional, Hendriks, Mathijs P, additional, Edhemovic, Ibrahim, additional, Cervantes, Andrés, additional, Nilsson, Per J, additional, Glimelius, Bengt, additional, van de Velde, Cornelis J H, additional, Hospers, Geke A P, additional, Østergaard, L., additional, Svendsen Jensen, F., additional, Pfeiffer, P., additional, Jensen, K.E.J., additional, Hendriks, M.P., additional, Schreurs, W.H., additional, Knol, H.P., additional, van der Vliet, J.J., additional, Tuynman, J.B., additional, Bruynzeel, A.M.E., additional, Kerver, E.D., additional, Festen, S., additional, van Leerdam, M.E., additional, Beets, G.L., additional, Dewit, L.G.H., additional, Punt, C.J.A., additional, Tanis, P.J., additional, Geijsen, E.D., additional, Nieboer, P., additional, Bleeker, W.A., additional, Ten Tije, A.J., additional, Crolla, R.M.P.H., additional, van de Luijtgaarden, A.C.M., additional, Dekker, J.W.T., additional, Immink, J.M., additional, Jeurissen, F.J.F., additional, Marinelli, A.W.K.S., additional, Ceha, H.M., additional, Stam, T.C., additional, Quarles an Ufford, P., additional, Steup, W.H., additional, Imholz, A.L.T., additional, Bosker, R.J.I., additional, Bekker, J.H.M., additional, Creemers, G.J., additional, Nieuwenhuijzen, G.A.P., additional, van den Berg, H., additional, van der Deure, W.M., additional, Schmitz, R.F., additional, van Rooijen, J.M., additional, Olieman, A.F.T., additional, van den Bergh, A.C.M., additional, de Groot, D.J.A., additional, Havenga, K., additional, Beukema, J.C., additional, de Boer, J., additional, Veldman, P.H.J.M., additional, Siemerink, E.J.M., additional, Vanstiphout, J.W.P., additional, de Valk, B., additional, Eijsbouts, Q.A.J., additional, Polée, M.B., additional, Hoff, C., additional, Slot, A., additional, Kapiteijn, H.W., additional, Peeters, K.C.M.J., additional, Peters, F.P., additional, Nijenhuis, P.A., additional, Radema, S.A., additional, de Wilt, H., additional, Braam, P., additional, Veldhuis, G.J., additional, Hess, D., additional, Rozema, T., additional, Reerink, O., additional, Ten Bokkel Huinink, D., additional, Pronk, A., additional, Vos, J., additional, Tascilar, M., additional, Patijn, G.A., additional, Kersten, C., additional, Mjåland, O., additional, Grønlie Guren, M., additional, Nesbakken, A.N., additional, Benedik, J., additional, Edhemovic, I., additional, Velenik, V., additional, Capdevila, J., additional, Espin, E., additional, Salazar, R., additional, Biondo, S., additional, Pachón, V., additional, die Trill, J., additional, Aparicio, J., additional, Garcia Granero, E., additional, Safont, M.J., additional, Bernal, J.C., additional, Cervantes, A., additional, Espí Macías, A., additional, Malmberg, L., additional, Svaninger, G., additional, Hörberg, H., additional, Dafnis, G., additional, Berglund, A., additional, Österlund, L., additional, Kovacs, K., additional, Hol, J., additional, Ottosson, S., additional, Carlsson, G., additional, Bratthäll, C., additional, Assarsson, J., additional, Lödén, B.L., additional, Hede, P., additional, Verbiené, I., additional, Hallböök, O., additional, Johnsson, A., additional, Lydrup, M.L., additional, Villmann, K., additional, Matthiessen, P., additional, Svensson, J.H., additional, Haux, J., additional, Skullman, S., additional, Fokstuen, T., additional, Holm, T., additional, Flygare, P., additional, Walldén, M., additional, Lindh, B., additional, Lundberg, O., additional, Radu, C., additional, Påhlman, L., additional, Piwowar, A., additional, Smedh, K., additional, Palenius, U., additional, Jangmalm, S., additional, Parinkh, P., additional, Kim, H., additional, and Silviera, M.L., additional

Published
2021
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21. Intraoperative electrochemotherapy of colorectal liver metastases: A prospective phase II study

Author

Edhemovic, Ibrahim, primary, Brecelj, Erik, additional, Cemazar, Maja, additional, Boc, Nina, additional, Trotovsek, Blaz, additional, Djokic, Mihajlo, additional, Dezman, Rok, additional, Ivanecz, Arpad, additional, Potrc, Stojan, additional, Bosnjak, Masa, additional, Markelc, Bostjan, additional, Kos, Bor, additional, Miklavcic, Damijan, additional, Gasljevic, Gorana, additional, and Sersa, Gregor, additional

Published
2020
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22. Erratum to “Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer – Results of the international randomized RAPIDO-trial” [Radiother. Oncol. 147 (2020) 75–83]

Author

van der Valk, Maxime J.M., primary, Marijnen, Corrie A.M., additional, van Etten, Boudewijn, additional, Dijkstra, Esmée A., additional, Hilling, Denise E., additional, Meershoek-Klein Kranenbarg, Elma, additional, Putter, Hein, additional, Roodvoets, Annet G.H., additional, Bahadoer, Renu R., additional, Fokstuen, Tone, additional, Jan ten Tije, Albert, additional, Capdevila, Jaume, additional, Hendriks, Mathijs P., additional, Edhemovic, Ibrahim, additional, Cervantes, Andrès M.R., additional, de Groot, Derk Jan A., additional, Nilsson, Per J., additional, Glimelius, Bengt, additional, van de Velde, Cornelis J.H., additional, and Hospers, Geke A.P., additional

Published
2020
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23. Short-course radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial.

Author

Hospers, Geke, primary, Bahadoer, Renu R., additional, Dijkstra, Esmee A., additional, van Etten, Boudewijn, additional, Marijnen, Corrie, additional, Putter, Hein, additional, Meershoek – Klein Kranenbarg, Elma, additional, Roodvoets, Annet G., additional, Nagtegaal, Iris D., additional, Beets-Tan, Regina GH, additional, Blomqvist, Lennart K., additional, Fokstuen, Tone, additional, ten Tije, Albert J., additional, Capdevila, Jaume, additional, Hendriks, Mathijs P., additional, Edhemovic, Ibrahim, additional, Cervantes, Andres, additional, Nilsson, Per J., additional, Glimelius, Bengt, additional, and Van De Velde, Cornelis J. H., additional

Published
2020
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24. Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer - Results of the international randomized RAPIDO-trial

Author

van der Valk, Maxime J. M., Marijnen, Corrie A. M., van Etten, Boudewijn, Dijkstra, Esmee A., Hilling, Denise E., Kranenbarg, Elma Meershoek-Klein, Putter, Hein, Roodvoets, Annet G. H., Bahadoer, Renu R., Fokstuen, Tone, ten Tije, Albert Jan, Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andres M. R., de Groot, Derk Jan A., Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J. H., Hospers, Geke A. P., van der Valk, Maxime J. M., Marijnen, Corrie A. M., van Etten, Boudewijn, Dijkstra, Esmee A., Hilling, Denise E., Kranenbarg, Elma Meershoek-Klein, Putter, Hein, Roodvoets, Annet G. H., Bahadoer, Renu R., Fokstuen, Tone, ten Tije, Albert Jan, Capdevila, Jaume, Hendriks, Mathijs P., Edhemovic, Ibrahim, Cervantes, Andres M. R., de Groot, Derk Jan A., Nilsson, Per J., Glimelius, Bengt, van de Velde, Cornelis J. H., and Hospers, Geke A. P.

Abstract

Background: Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision is widely accepted as the standard of care for high-risk rectal cancer. Adjuvant chemotherapy is advised in several international guidelines, although the survival benefit remains unclear and compliance is poor. The current multidisciplinary approach has led to major improvements in local control, yet the occurrence of distant metastases has not decreased accordingly. The combination of short-course radiotherapy (SCRT) and chemotherapy in the waiting period before surgery might have several benefits, including higher compliance, downstaging and better effect of systemic therapy. Methods: This is an investigator-initiated, international multicentre randomized phase III trial. High-risk rectal cancer patients were randomized to SCRT followed by chemotherapy (6 cycles CAPOX or alternatively 9 cycles FOLFOX4) and subsequent surgery, or long-course radiotherapy (25-28 x 2-1.8 Gy) with concomitant capecitabine followed by surgery and optional postoperative chemotherapy (8 cycles CAPOX or 12 cycles FOLFOX4) according to local institutions' policy. The primary endpoint is time to disease related treatment failure. Here, we report the compliance, toxicity and postoperative complications in both study groups. Findings: Between June 2011 and June 2016, 920 patients were enrolled. Of these, 901 were evaluable (460 in the experimental arm and 441 in the standard arm). All patients in the experimental arm received 5 x 5 Gy radiotherapy, and 84% of all patients received at least 75% of the prescribed chemotherapy. In the standard arm, the compliance for CRT was 93% and 58% for postoperative chemotherapy. Toxicity >= grade 3 occurred in 48% of patients in the experimental arm, compared to 25% of patients in the standard arm during preoperative treatment and 35% of patients during postoperative chemotherapy. No statistically significant differences in surgical procedures or postoperative compli, Correction in: RADIOTHERAPY AND ONCOLOGY, Volume: 147, Pages: E1-E1, DOI: 10.1016/j.radonc.2020.06.006

Published
2020
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25. Electrochemotherapy – Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration

Author

Campana, Luca G., primary, Edhemovic, Ibrahim, additional, Soden, Declan, additional, Perrone, Anna M., additional, Scarpa, Marco, additional, Campanacci, Laura, additional, Cemazar, Maja, additional, Valpione, Sara, additional, Miklavčič, Damijan, additional, Mocellin, Simone, additional, Sieni, Elisabetta, additional, and Sersa, Gregor, additional

Published
2019
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26. Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study

Author

Edhemovic Ibrahim, Oblak Irena, Anderluh Franc, Bracko Matej, Music Maja, Ocvirk Janja, Velenik Vaneja, Brecelj Erik, Kropivnik Mateja, and Omejc Mirko

Subjects
capecitabine, chemoradiation, bevacizumab, locally advanced rectal cancer, LARC, phase II study, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Preoperative capecitabine-based chemoradiation is a standard treatment for locally advanced rectal cancer (LARC). Here, we explored the safety and efficacy of the addition of bevacizumab to capecitabine and concurrent radiotherapy for LARC. Methods Patients with MRI-confirmed stage II/III rectal cancer received bevacizumab 5 mg/kg i.v. 2 weeks prior to neoadjuvant chemoradiotherapy followed by bevacizumab 5 mg/kg on Days 1, 15 and 29, capecitabine 825 mg/m2 twice daily on Days 1-38, and concurrent radiotherapy 50.4 Gy (1.8 Gy/day, 5 days/week for 5 weeks + three 1.8 Gy/day), starting on Day 1. Total mesorectal excision was scheduled 6-8 weeks after completion of chemoradiotherapy. Tumour regression grades (TRG) were evaluated on surgical specimens according to Dworak. The primary endpoint was pathological complete response (pCR). Results 61 patients were enrolled (median age 60 years [range 31-80], 64% male). Twelve patients (19.7%) had T3N0 tumours, 1 patient T2N1, 19 patients (31.1%) T3N1, 2 patients (3.3%) T2N2, 22 patients (36.1%) T3N2 and 5 patients (8.2%) T4N2. Median tumour distance from the anal verge was 6 cm (range 0-11). Grade 3 adverse events included dermatitis (n = 6, 9.8%), proteinuria (n = 4, 6.5%) and leucocytopenia (n = 3, 4.9%). Radical resection was achieved in 57 patients (95%), and 42 patients (70%) underwent sphincter-preserving surgery. TRG 4 (pCR) was recorded in 8 patients (13.3%) and TRG 3 in 9 patients (15.0%). T-, N- and overall downstaging rates were 45.2%, 73.8%, and 73.8%, respectively. Conclusions This study demonstrates the feasibility of preoperative chemoradiotherapy with bevacizumab and capecitabine. The observed adverse events of neoadjuvant treatment are comparable with those previously reported, but the pCR rate was lower.

Published
2011
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28. Acute Toxicity and Tumor Response in Locally Advanced Rectal Cancer After Preoperative Chemoradiation Therapy With Shortening of the Overall Treatment Time Using Intensity-Modulated Radiation Therapy With Simultaneous Integrated Boost: A Phase 2 Trial

Author

But-Hadzic, Jasna, primary, Anderluh, Franc, additional, Brecelj, Erik, additional, Edhemovic, Ibrahim, additional, Secerov-Ermenc, Ajra, additional, Hudej, Rihard, additional, Jeromen, Ana, additional, Kozelj, Miran, additional, Krebs, Bojan, additional, Oblak, Irena, additional, Omejc, Mirko, additional, Vogrin, Andrej, additional, and Velenik, Vaneja, additional

Published
2016
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33. Compliance, acute toxicity and postoperative complications of short-course radiotherapy followed by chemotherapy and surgery for high-risk rectal cancer. results of the randomized RAPIDO-trial.

Author

van der Valk, Maxime, van Etten, Boudewijn, Marijnen, Corrie, Dijkstra, Esmée, Hilling, Denise, Klein Kranenbarg, Elma Meershoek-, Nilsson, Per, Putter, Hein, Roodvoets, Annet, Fokstuen, Tone, Jan ten Tije, Bert, Capdevila, Jaume, Hendriks, Mathijs, Edhemovic, Ibrahim, Jan de Groot, Derk, Cervantes, Andrès, Glimelius, Bengt, Van de Velde, Cornelis, Hospers, Geke, and Collaborative Investigators RAPIDO Trial

Subjects
SURGICAL complications, RECTAL cancer, RECTAL surgery, CANCER chemotherapy, RADIOTHERAPY, ADJUVANT treatment of cancer
Abstract

B Background: b Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision is widely accepted as the standard of care for high-risk rectal cancer. All patients in the experimental arm received 5x5 Gy radiotherapy, and 84% of all patients received at least 75% of the prescribed preoperative chemotherapy courses. [Extracted from the article]

Published
2020
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