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1. Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals

Author

Spinner, Christoph D., Bell, Samira, Einsele, Hermann, Tremblay, Cécile, Goldman, Michel, Chagla, Zain, Finckh, Axel, Edwards, Christopher J., Aurer, Igor, Launay, Odile, Casañas i Comabella, Carolina, James, Samantha, Dube, Sabada, Borkowska, Katarzyna, Jah, Fungwe, Kandeil, Walid, Yokota, Renata T. C., Artaud, Cécile, Gottenberg, Jacques-Eric, Gesualdo, Loreto, Bertrand, Dominique, Arnetorp, Sofie, and Magiorkinis, Gkikas

Published
2025
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3. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Zayat, Ahmed, Machado, Ana Rita, Cuervo, Andrea, Mahto, Arti, Cubuk, Cankut, Rawlings, Charlotte, Mosanya, Chijioke, Buckley, Chris, Holroyd, Chris, Maskall, Debbie, Carlucci, Francesco, Thorborn, Georgina, Tan, Gina, Lliso-Ribera, Gloria, Rizvi, Hasan, Peel, Joanna, Fonseca, João Eurico, Isaacs, John, Ramírez, Julio, Meric de Bellefon, Laurent, Fossati-Jimak, Liliane, Githinji, Mary, Congia, Mattia, Millar, Neal, Purkayastha, Nirupam, Celis, Raquel, Seth, Rakhi, Hands-Greenwood, Rebecca, Landewé, Robert, Perniola, Simone, Alivernini, Stefano, Marcia, Stefano, Marini, Stefano, Kelly, Stephen, Romão, Vasco, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Warren, Louise, Jaworska, Edyta, Bombardieri, Michele, Lewis, Myles J, Humby, Frances, Pratt, Arthur G, Filer, Andrew, Gendi, Nagui, Cauli, Alberto, Choy, Ernest, McInnes, Iain, Durez, Patrick, Edwards, Christopher J, Buch, Maya H, Gremese, Elisa, Taylor, Peter C, Ng, Nora, Cañete, Juan D, Raizada, Sabrina, McKay, Neil D, Jadon, Deepak, Sainaghi, Pier Paolo, Stratton, Richard, Ehrenstein, Michael R, Ho, Pauline, Pereira, Joaquim P, Dasgupta, Bhaskar, Gorman, Claire, Galloway, James, Chinoy, Hector, van der Heijde, Désirée, Sasieni, Peter, Barton, Anne, and Pitzalis, Costantino

Published
2023
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6. Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE)

Author

Edwards, Christopher J., Bellinvia, Salvatore, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima Tatiana, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, Vaglio, Augusto, Editorial Board Member, Ravindran, Vinod, editor, Santhanam, Sham, editor, and Goyal, Mohit, editor

Published
2022
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7. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

Author

Paton, Nicholas, Hayden, Fred, Darbyshire, Janet, Lucas, Amy, Lorch, Ulrika, Freedman, Andrew, Knight, Richard, Julious, Stevan, Byrne, Rachel, Cubas Atienzar, Ana, Jones, Jayne, Williams, Chris, Song, Anna, Dixon, Jan, Alexandersson, Anja, Hatchard, Parys, Tilt, Emma, Titman, Andrew, Doce Carracedo, Ale, Chandran Gorner, Vatsi, Davies, Andrea, Woodhouse, Louis, Carlucci, Nicola, Okenyi, Emmanuel, Bula, Marcin, Dodd, Kate, Gibney, Jennifer, Dry, Lesley, Rashid Gardner, Zalina, Sammour, Amin, Cole, Christine, Rowland, Tim, Tsakiroglu, Maria, Yip, Vincent, Osanlou, Rostam, Stewart, Anna, Parker, Ben, Turgut, Tolga, Ahmed, Afshan, Starkey, Kay, Subin, Sujamole, Stockdale, Jennifer, Herring, Lisa, Baker, Jonathon, Oliver, Abigail, Pacurar, Mihaela, Owens, Dan, Munro, Alistair, Babbage, Gavin, Faust, Saul, Harvey, Matthew, Pratt, Danny, Nagra, Deepak, Vyas, Aashish, Khoo, Saye H, FitzGerald, Richard, Saunders, Geoffrey, Middleton, Calley, Ahmad, Shazaad, Edwards, Christopher J, Hadjiyiannakis, Dennis, Walker, Lauren, Lyon, Rebecca, Shaw, Victoria, Mozgunov, Pavel, Periselneris, Jimstan, Woods, Christie, Bullock, Katie, Hale, Colin, Reynolds, Helen, Downs, Nichola, Ewings, Sean, Buadi, Amanda, Cameron, David, Edwards, Thomas, Knox, Emma, Donovan-Banfield, I'ah, Greenhalf, William, Chiong, Justin, Lavelle-Langham, Lara, Jacobs, Michael, Northey, Josh, Painter, Wendy, Holman, Wayne, Lalloo, David G, Tetlow, Michelle, Hiscox, Julian A, Jaki, Thomas, Fletcher, Thomas, and Griffiths, Gareth

Published
2023
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8. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Author

Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kanji, Nasir, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Bawa, Tanveer, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Maallah, Mina, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, Faust, Saul N, Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris, Katechia, Kashyap, Cooper, Alison, Freedman, Andrew, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Harrison, Elizabeth, Snashall, Emma, Mallon, Lewis, Burton, Katharine, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Murira, Jennifer, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Sturdy, Ann, Barcella, Lara, Soussi, Najwa, Mpelembue, Mushiya, Raj, Sreena, Sharma, Rajni, Corrah, Tumena, John, Laurence, Whittington, Ashley, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Abeywickrama, Movin, Spence, Niamh, Packham, Alice, Serafimova, Teona, Aslam, Suahil, McGreevy, Caitlin, Borca, Alessandro, DeLosSantosDominguez, Pamela, Palmer, Emily, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Gokani, Karishma, Trinham, Charlotte, Sabine, Charlette, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Stone, Megan, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Turnbull, Iain, Morshead, Gertraud, Drake-Brockman, Rachael, Smith, Catherine, Li, Grace, Kasanyinga, Mwila, Clutterbuck, Elizabeth A, Bibi, Sagida, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicia, Nabunjo, Martha, Osuji, Carol, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Grierson, Jacques, Males, Samantha, Askoolam, Krishna, Barry, Joshua, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karen, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Hamal, Shama, Ricamara, Marivic, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalvescordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Appleby, Kim, Dineen, Emily, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Denny, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Habash-Bailey, Haniah, Magan, Javier, and Hardy, Anna

Published
2022
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9. Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

Author

Donovan-Banfield, I’ah, Penrice-Randal, Rebekah, Goldswain, Hannah, Rzeszutek, Aleksandra M., Pilgrim, Jack, Bullock, Katie, Saunders, Geoffrey, Northey, Josh, Dong, Xiaofeng, Ryan, Yan, Reynolds, Helen, Tetlow, Michelle, Walker, Lauren E., FitzGerald, Richard, Hale, Colin, Lyon, Rebecca, Woods, Christie, Ahmad, Shazaad, Hadjiyiannakis, Dennis, Periselneris, Jimstan, Knox, Emma, Middleton, Calley, Lavelle-Langham, Lara, Shaw, Victoria, Greenhalf, William, Edwards, Thomas, Lalloo, David G., Edwards, Christopher J., Darby, Alistair C., Carroll, Miles W., Griffiths, Gareth, Khoo, Saye H., Hiscox, Julian A., and Fletcher, Thomas

Published
2022
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12. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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14. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

Author

Thompson, Charlotte, Bugatti, Serena, Bellan, Mattia, Congia, Mattia, Holroyd, Christopher, Pratt, Arthur, Cabral da Fonseca, João Eurico, White, Laura, Warren, Louise, Peel, Joanna, Hands, Rebecca, Fossati-Jimack, Liliane, Hadfield, Gaye, Thorborn, Georgina, Ramirez, Julio, Celis, Raquel, Humby, Frances, Durez, Patrick, Buch, Maya H, Lewis, Myles J, Rizvi, Hasan, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Mahto, Arti, Montecucco, Carlomaurizio, Lauwerys, Bernard, Ng, Nora, Ho, Pauline, Bombardieri, Michele, Romão, Vasco C, Verschueren, Patrick, Kelly, Stephen, Sainaghi, Pier Paolo, Gendi, Nagui, Dasgupta, Bhaskar, Cauli, Alberto, Reynolds, Piero, Cañete, Juan D, Moots, Robert, Taylor, Peter C, Edwards, Christopher J, Isaacs, John, Sasieni, Peter, Choy, Ernest, and Pitzalis, Costantino

Published
2021
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16. JAK inhibitors in systemic lupus erythematosus: Translating pathogenesis into therapy.

Author

Ceobanu, Gabriela and Edwards, Christopher J

Subjects
*IMMUNE complexes, *NUCLEAR structure, *KINASE inhibitors, *AUTOANTIBODIES, *DRUG development
Abstract

Systemic lupus erythematosus (SLE) is a complex multi-organ autoimmune disease marked by the production of autoantibodies against nuclear structures, formation of immune complexes, and chronic inflammation triggered by their tissular deposition. SLE is characterized by alternating periods of relapse and remission and each flare has the potential to cause new organ damage related to either the disease process or the medication toxicity. Despite remarkable progress across its multiple domains, SLE is still an area with many unmet needs, calling for innovative and practical solutions. The efforts of the drug development programme in lupus have led to considerable growth in the last decade, owing to the approval of belimumab, anifrolumab, and voclosporin. The increasing understanding of the pathogenesis of the disease has enabled the exploration of novel therapeutic strategies. New discoveries in the intricate cytokine kaleidoscope of lupus have made the concept of targeted therapy an attractive and promising research focus. JAK inhibitors are oral targeted therapies approved for a wide variety of diseases across the Rheumatology, Gastroenterology, Dermatology, and Haematology fields. Multiple JAKis are currently being investigated in SLE. This paper aims to summarize existing data coming from both clinical trials and case reports regarding the use of JAK inhibitors in SLE. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Pain Reduction With Oral Methotrexate in Knee Osteoarthritis: A Randomized, Placebo-Controlled Clinical Trial.

Author

Kingsbury, Sarah R., Tharmanathan, Puvan, Keding, Ada, Watt, Fiona E., Scott, David L., Roddy, Edward, Birrell, Fraser, Arden, Nigel K., Bowes, Mike, Arundel, Catherine, Watson, Michelle, Ronaldson, Sarah J., Hewitt, Catherine, Doherty, Michael, Moots, Robert J., O'Neill, Terence W., Green, Michael, Patel, Gulam, Garrood, Toby, and Edwards, Christopher J.

Subjects
KNEE osteoarthritis, KNEE pain, PAIN management, PATIENT compliance, METHOTREXATE
Abstract

In this randomized, double-blind, placebo-controlled trial, 207 participants with knee osteoarthritis with inadequate response to current medications were randomly assigned to receive methotrexate or placebo. Average knee pain at 6 months measured using a numerical rating scale decreased from 6.4 to 5.1 in the methotrexate group versus 6.8 to 6.2 in the placebo group. Findings suggest that oral methotrexate added to usual medications can reduce knee pain in patients with osteoarthritis. Visual Abstract. Pain Reduction With Oral Methotrexate in Knee Osteoarthritis: In this randomized, double-blind, placebo-controlled trial, 207 participants with knee osteoarthritis with inadequate response to current medications were randomly assigned to receive methotrexate or placebo. Average knee pain at 6 months measured using a numerical rating scale decreased from 6.4 to 5.1 in the methotrexate group versus 6.8 to 6.2 in the placebo group. Findings suggest that oral methotrexate added to usual medications can reduce knee pain in patients with osteoarthritis. Background: Treatments for osteoarthritis (OA) are limited. Previous small studies suggest that the antirheumatic drug methotrexate may be a potential treatment for OA pain. Objective: To assess symptomatic benefits of methotrexate in knee OA (KOA). Design: A multicenter, randomized, double-blind, placebo-controlled trial done between 13 June 2014 and 13 October 2017. (ISRCTN77854383; EudraCT: 2013-001689-41) Setting: 15 secondary care musculoskeletal clinics in the United Kingdom. Participants: A total of 207 participants with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months with inadequate response to current medication were approached for inclusion. Intervention: Participants were randomly assigned 1:1 to oral methotrexate once weekly (6-week escalation 10 to 25 mg) or matched placebo over 12 months and continued usual analgesia. Measurements: The primary end point was average knee pain (numerical rating scale [NRS] 0 to 10) at 6 months, with 12-month follow-up to assess longer-term response. Secondary end points included knee stiffness and function outcomes and adverse events (AEs). Results: A total of 155 participants (64% women; mean age, 60.9 years; 50% Kellgren–Lawrence grade 3 to 4) were randomly assigned to methotrexate (n  = 77) or placebo (n  = 78). Follow-up was 86% (n  = 134; methotrexate: 66, placebo: 68) at 6 months. Mean knee pain decreased from 6.4 (SD, 1.80) at baseline to 5.1 (SD, 2.32) at 6 months in the methotrexate group and from 6.8 (SD, 1.62) to 6.2 (SD, 2.30) in the placebo group. The primary intention-to-treat analysis showed a statistically significant pain reduction of 0.79 NRS points in favor of methotrexate (95% CI, 0.08 to 1.51; P  = 0.030). There were also statistically significant treatment group differences in favor of methotrexate at 6 months for Western Ontario and McMaster Universities Osteoarthritis Index stiffness (0.60 points [CI, 0.01 to 1.18]; P  = 0.045) and function (5.01 points [CI, 1.29 to 8.74]; P  = 0.008). Treatment adherence analysis supported a dose-response effect. Four unrelated serious AEs were reported (methotrexate: 2, placebo: 2). Limitation: Not permitting oral methotrexate to be changed to subcutaneous delivery for intolerance. Conclusion: Oral methotrexate added to usual medications demonstrated statistically significant reduction in KOA pain, stiffness, and function at 6 months. Primary Funding Source: Versus Arthritis. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Author

Aboagye, Jeremy, Adams, Kelly, Ali, Aabidah, Allen, Elizabeth R., Allen, Lauren, Allison, Jennifer L., Andritsou, Foteini, Anslow, Rachel, Arbe-Barnes, Edward H., Baker, Megan, Baker, Natalie, Baker, Philip, Baleanu, Ioana, Barker, Debbie, Barnes, Eleanor, Barrett, Jordan R., Barrett, Kelly, Bates, Louise, Batten, Alexander, Beadon, Kirsten, Beckley, Rebecca, Bellamy, Duncan, Berg, Adam, Bermejo, Laura, Berrie, Eleanor, Beveridge, Amy, Bewley, Kevin, Bijker, Else M., Birch, Geeta, Blackwell, Luke, Bletchly, Heather, Blundell, Caitlin L., Blundell, Susannah R., Bolam, Emma, Boland, Elena, Bormans, Daan, Borthwick, Nicola, Boukas, Konstantinos, Bower, Thomas, Bowring, Francesca, Boyd, Amy, Brenner, Tanja, Brown, Phillip, Brown-O'Sullivan, Charlie, Bruce, Scott, Brunt, Emily, Burbage, Jamie, Burgoyne, Joshua, Buttigieg, Karen R., Byard, Nicholas, Cabera Puig, Ingrid, Camara, Susana, Cao, Michelangelo, Cappuccini, Federica, Carr, Melanie, Carroll, Miles W., Cashen, Paul, Cavey, Ana, Chadwick, Jim, Challis, Ruth, Chapman, David, Charles, David, Chelysheva, Irina, Cho, Jee-Sun, Cifuentes, Liliana, Clark, Elizabeth, Collins, Sarah, Conlon, Christopher P., Coombes, Naomi S., Cooper, Rachel, Cooper, Cushla, Crocker, Wendy E.M., Crosbie, Sarah, Cullen, Dan, Cunningham, Christina, Cuthbertson, Fiona, Datoo, Brad E., Dando, Lynne, Datoo, Mehreen S., Datta, Chandrabali, Davies, Hannah, Davies, Sarah, Davis, Elizabeth J., Davis, Judith, Dearlove, David, Demissie, Tesfaye, Di Marco, Stefania, Di Maso, Claudio, DiTirro, Danielle, Docksey, Claire, Dong, Tao, Donnellan, Francesca R., Douglas, Naomi, Downing, Charlotte, Drake, Jonathan, Drake-Brockman, Rachael, Drury, Ruth E., Dunachie, Susanna J., Edwards, Christopher J., Edwards, Nick J., El Muhanna, Omar, Elias, Sean C., Elliott, Ryan S., Elmore, Michael J., English, Marcus Rex, Felle, Sally, Feng, Shuo, Ferreira Da Silva, Carla, Field, Samantha, Fisher, Richard, Fixmer, Carine, Ford, Karen J., Fowler, Jamie, Francis, Emma, Frater, John, Furze, Julie, Galian-Rubio, Pablo, Galloway, Celine, Garlant, Harriet, Gavrila, Madita, Gibbons, Felicity, Gibbons, Karyna, Gilbride, Ciaran, Gill, Hardeep, Godwin, Kerry, Gordon-Quayle, Katherine, Gorini, Giacomo, Goulston, Lyndsey, Grabau, Caroline, Gracie, Lara, Graham, Nichola, Greenwood, Nicola, Griffiths, Oliver, Gupta, Gaurav, Hamilton, Elizabeth, Hanumunthadu, Brama, Harris, Stephanie A., Harris, Tara, Harrison, Daisy, Hart, Thomas C., Hartnell, Birgit, Haskell, Louise, Hawkins, Sophia, Henry, John Aaron, Hermosin Herrera, Macarena, Hill, David, Hill, Jennifer, Hodges, Gina, Hodgson, Susanne H.C., Horton, Katie L., Howe, Elizabeth, Howell, Nicola, Howes, Jessica, Huang, Ben, Humphreys, Jonathan, Humphries, Holly E., Iveson, Poppy, Jackson, Frederic, Jackson, Susan, Jauregui, Sam, Jeffers, Helen, Jones, Bryony, Jones, Christine E., Jones, Elizabeth, Jones, Kathryn, Joshi, Amar, Kailath, Reshma, Keen, Jade, Kelly, Dearbhla M., Kelly, Sarah, Kelly, Debbie, Kerr, David, Khan, Liaquat, Khozoee, Baktash, Killen, Annabel, Kinch, Jasmin, King, Lloyd D.W., King, Thomas B., Kingham, Lucy, Klenerman, Paul, Knight, Julian C., Knott, Daniel, Koleva, Stanislava, Lang, Gail, Larkworthy, Colin W., Larwood, Jessica P.J., Law, Rebecca, Lee, Arlene, Lee, Kim Y.N., Lees, Emily A., Leung, Stephanie, Li, Yuanyuan, Lias, Amelia M., Linder, Aline, Lipworth, Samuel, Liu, Shuchang, Liu, Xinxue, Lloyd, Stephanie, Loew, Lisa, Lopez Ramon, Raquel, Madhavan, Meera, Mainwaring, David O., Mallett, Garry, Mansatta, Kushal, Marinou, Spyridoula, Marius, Phedra, Marlow, Emma, Marriott, Paula, Marshall, Julia L., Martin, Jane, Masters, Shauna, McEwan, Joanne, McGlashan, Joanna L., McInroy, Lorna, McRobert, Nicky, Megson, Clare, Mentzer, Alexander J., Mirtorabi, Neginsadat, Mitton, Celia, Moore, Maria, Moran, Marni, Morey, Ella, Morgans, Róisín, Morris, Susan J., Morrison, Hazel Morrison, Morshead, Gertraud, Morter, Richard, Moya, Nathifa A., Mukhopadhyay, Ekta, Muller, Jilly, Munro, Claire, Murphy, Sarah, Mweu, Philomena, Noé, Andrés, Nugent, Fay L., O'Brien, Katie, O'Connor, Daniel, Oguti, Blanché, Olchawski, Victoria, Oliveira, Catarina, O'Reilly, Peter John, Osborne, Piper, Owen, Lydia, Owino, Nelly, Papageorgiou, Panagiotis, Parracho, Helena, Parsons, Karen, Patel, Bhumika, Patrick-Smith, Maia, Peng, Yanchun, Penn, Elizabeth J., Peralta-Alvarez, Marco Polo, Perring, James, Petropoulos, Christos, Phillips, Daniel J., Pipini, Dimitra, Pollard, Samuel, Poulton, Ian, Pratt, Danny, Presland, Laura, Proud, Pamela C., Provstgaard-Morys, Samuel, Pueschel, Sophie, Pulido, David, Rabara, Ria, Radia, Kajal, Rajapaska, Durga, Ramos Lopez, Fernando, Ratcliffe, Helen, Rayhan, Sara, Rees, Byron, Reyes Pabon, Emilia, Roberts, Hannah, Robertson, Isla, Roche, Sophie, Rollier, Christine S., Romani, Rossana, Rose, Zoe, Rudiansyah, Indra, Sabheha, Sabeha, Salvador, Stephannie, Sanders, Helen, Sanders, Katherine, Satti, Iman, Sayce, Chloe, Schmid, Annina B., Schofield, Ella, Screaton, Gavin, Sedik, Cynthia, Seddiqi, Samiullah, Segireddy, Rameswara R., Selby, Beatrice, Shaik, Imam, Sharpe, Hannah R., Shaw, Robert, Shea, Adam, Silk, Sarah, Silva-Reyes, Laura, Skelly, Donal T., Smith, David J., Smith, Daniel C., Smith, Nicholas, Spencer, Alexandra J., Spoors, Louise, Stafford, Elizabeth, Stamford, Imogen, Stockdale, Lisa, Stockley, David, Stockwell, Lisa V., Stokes, Matthew, Strickland, Louise H., Stuart, Arabella, Sulaiman, Sulaiman, Summerton, Eloise, Swash, Zoe, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tanner, Rachel, Taylor, Iona, Taylor, Keja, Taylor, Ursula, te Water Naude, Rebecca, Themistocleous, Andreas, Thomas, Merin, Thomas, Tonia M., Thompson, Amber, Thompson, Kevin, Thornton-Jones, Viv, Tinh, Lan, Tomic, Adriana, Tonks, Susan, Towner, James, Tran, Nguyen, Tree, Julian A., Truby, Adam, Turner, Cheryl, Turner, Richard, Ulaszewska, Marta, Varughese, Rachel, Verbart, Dennis, Verheul, Marije K., Vichos, Iason, Walker, Laura, Wand, Matthew E., Watkins, Bridget, Welch, Jessica, West, Alison J., White, Caroline, White, Rachel, Williams, Paul, Woodyer, Mark, Worth, Andrew T., Wright, Daniel, Wrin, Terri, Yao, Xin Li, Zbarcea, Diana-Andreea, Zizi, Dalila, Ramasamy, Maheshi N, Minassian, Angela M, Ewer, Katie J, Flaxman, Amy L, Folegatti, Pedro M, Owens, Daniel R, Voysey, Merryn, Aley, Parvinder K, Angus, Brian, Babbage, Gavin, Belij-Rammerstorfer, Sandra, Berry, Lisa, Bibi, Sagida, Bittaye, Mustapha, Cathie, Katrina, Chappell, Harry, Charlton, Sue, Cicconi, Paola, Clutterbuck, Elizabeth A, Colin-Jones, Rachel, Dold, Christina, Emary, Katherine R W, Fedosyuk, Sofiya, Fuskova, Michelle, Gbesemete, Diane, Green, Catherine, Hallis, Bassam, Hou, Mimi M, Jenkin, Daniel, Joe, Carina C D, Kelly, Elizabeth J, Kerridge, Simon, Lawrie, Alison M, Lelliott, Alice, Lwin, May N, Makinson, Rebecca, Marchevsky, Natalie G, Mujadidi, Yama, Munro, Alasdair P S, Pacurar, Mihaela, Plested, Emma, Rand, Jade, Rawlinson, Thomas, Rhead, Sarah, Robinson, Hannah, Ritchie, Adam J, Ross-Russell, Amy L, Saich, Stephen, Singh, Nisha, Smith, Catherine C, Snape, Matthew D, Song, Rinn, Tarrant, Richard, Themistocleous, Yrene, Thomas, Kelly M, Villafana, Tonya L, Warren, Sarah C, Watson, Marion E E, Douglas, Alexander D, Hill, Adrian V S, Lambe, Teresa, Gilbert, Sarah C, Faust, Saul N, and Pollard, Andrew J

Published
2020
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21. Comparison of Responsiveness of British Isles Lupus Assessment Group 2004 Index, Systemic Lupus Erythematosus Disease Activity Index 2000, and British Isles Lupus Assessment Group 2004 Systems Tally

Author

Yee, Chee‐Seng, Gordon, Caroline, Isenberg, David A., Griffiths, Bridget, Teh, Lee‐Suan, Bruce, Ian N., Ahmad, Yasmeen, Rahman, Anisur, Prabu, Athiveeraramapandian, Akil, Mohammed, McHugh, Neil, Edwards, Christopher J., DʼCruz, David, Khamashta, Munther A., and Farewell, Vernon T.

Published
2022
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22. The RESIST Study: Examining Cognitive Change in Rheumatoid Arthritis Patients with Mild Cognitive Impairment Being Treated with a TNF-Inhibitor Compared to a Conventional Synthetic Disease-Modifying Anti-Rheumatic Drug

Author

Marr, Calum, primary, McDowell, Bethany, additional, Holmes, Clive, additional, Edwards, Christopher J., additional, Cardwell, Christopher, additional, McHenry, Michelle, additional, Meenagh, Gary, additional, Teeling, Jessica L., additional, and McGuinness, Bernadette, additional

Published
2024
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24. Studies on Values of Digital Health

Author

Lee, Jeannie K., Erstad, Brian L., McBride, Ali, Edwards, Christopher J., Choi, Briana, Lee, Jeannie K., Erstad, Brian L., McBride, Ali, Edwards, Christopher J., and Choi, Briana

Abstract

Background: The landscape of digital health technologies (DHTs) has evolved significantly, encompassing diverse technologies and platforms. Among these, digital therapeutics (DTx) are software interventions designed to manage diseases and health conditions. Chronic insomnia, characterized by difficulty initiating or maintaining sleep with associated daytime symptoms, affects approximately 8% of adults in the United States (US) and imposes significant burdens on individuals and healthcare systems. Cognitive behavioral therapy for insomnia (CBT-I) is recommended as a first-line treatment, but its utilization is limited due to a shortage of certified providers. Somryst (Nox Health, Alpharetta, GA, US), a US Food and Drug Administration (FDA)-approved DTx, offers an alternative for delivering CBT-I. Objectives: This study aims to evaluate the current landscape of value frameworks for DHTs and DTx through a narrative review, as well as assess the economic impact of Somryst for chronic insomnia management. Methods: A literature search was conducted from September 2023 to January 2024 across multiple databases and websites, focusing on value frameworks for DHTs and DTx. A narrative approach was used to review and summarize findings from selected articles, assessing key elements of identified value frameworks based on previously identified value domains. Additionally, two budget impact analyses were performed over 1-year (primary analysis) and 3-year (secondary analysis) time horizons for (1) the total US population (net budget impact), and (2) a 1-million-member health plan (net budget impact, per-member-per-year (PMPY), per-member-per-month (PMPM)) using Excel. Costs and clinical outcomes associated with Somryst, CBT-I, CBT-I+self-help, and eszopiclone were derived from published literature, Merative Micromedex Red Book, and the Physician Fee Schedule. A scenario analysis using upper limits of probabilities of no-remission was conducted. A decision-tree model was specifie

Published
2024

29. Differences in management approaches for lupus nephritis within the UK

Author

Ibrahim, Sara T, primary, Edwards, Christopher J, additional, Ehrenstein, Michael R, additional, Griffiths, Bridget, additional, Gordon, Caroline, additional, Hewins, Peter, additional, Jayne, David, additional, Lightstone, Liz, additional, McLaren, Zoe, additional, Rhodes, Benjamin, additional, Vital, Edward M, additional, and Reynolds, John A, additional

Published
2023
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40. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Rivellese, Felice, primary, Nerviani, Alessandra, additional, Giorli, Giovanni, additional, Warren, Louise, additional, Jaworska, Edyta, additional, Bombardieri, Michele, additional, Lewis, Myles J, additional, Humby, Frances, additional, Pratt, Arthur G, additional, Filer, Andrew, additional, Gendi, Nagui, additional, Cauli, Alberto, additional, Choy, Ernest, additional, McInnes, Iain, additional, Durez, Patrick, additional, Edwards, Christopher J, additional, Buch, Maya H, additional, Gremese, Elisa, additional, Taylor, Peter C, additional, Ng, Nora, additional, Cañete, Juan D, additional, Raizada, Sabrina, additional, McKay, Neil D, additional, Jadon, Deepak, additional, Sainaghi, Pier Paolo, additional, Stratton, Richard, additional, Ehrenstein, Michael R, additional, Ho, Pauline, additional, Pereira, Joaquim P, additional, Dasgupta, Bhaskar, additional, Gorman, Claire, additional, Galloway, James, additional, Chinoy, Hector, additional, van der Heijde, Désirée, additional, Sasieni, Peter, additional, Barton, Anne, additional, Pitzalis, Costantino, additional, Zayat, Ahmed, additional, Machado, Ana Rita, additional, Cuervo, Andrea, additional, Mahto, Arti, additional, Cubuk, Cankut, additional, Rawlings, Charlotte, additional, Mosanya, Chijioke, additional, Buckley, Chris, additional, Holroyd, Chris, additional, Maskall, Debbie, additional, Carlucci, Francesco, additional, Thorborn, Georgina, additional, Tan, Gina, additional, Lliso-Ribera, Gloria, additional, Rizvi, Hasan, additional, Peel, Joanna, additional, Fonseca, João Eurico, additional, Isaacs, John, additional, Ramírez, Julio, additional, Meric de Bellefon, Laurent, additional, Fossati-Jimak, Liliane, additional, Githinji, Mary, additional, Congia, Mattia, additional, Millar, Neal, additional, Purkayastha, Nirupam, additional, Celis, Raquel, additional, Seth, Rakhi, additional, Hands-Greenwood, Rebecca, additional, Landewé, Robert, additional, Perniola, Simone, additional, Alivernini, Stefano, additional, Marcia, Stefano, additional, Marini, Stefano, additional, Kelly, Stephen, additional, and Romão, Vasco, additional

Published
2023
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43. International Survey to Evaluate Current Options for Subcutaneous Injection of Methotrexate (MTX) and a New Button-Free MTX Autoinjector.

Author

Müller-Ladner, Ulf, Edwards, Christopher J, and Erkens, Andreas

Subjects
*SUBCUTANEOUS injections, *METHOTREXATE, *NURSES as patients, *RHEUMATOLOGISTS, *PHYSICIANS, *RHEUMATOID arthritis
Abstract

Purpose: Prefilled syringes (PFS) and various types of pens are available for subcutaneous injection of methotrexate (MTX) in patients with rheumatoid arthritis or moderate to severe psoriasis. A new MTX pen with modernized button-free autoinjection technology was developed as a successor to a button-activated pen (metoject®/metex® PEN). To assess the needs of users and the relevance of features of the new MTX autoinjector an international online survey was performed. Methods: A structured questionnaire was distributed to physicians, nurses and patients in Germany, France, and the United Kingdom. Participants received illustrations and information about features of the new MTX autoinjector. Results: In total, 189 rheumatologists, 111 dermatologists, 90 nurses, and 180 patients answered the questions. Specific reasons for a preference for the use of MTX pens over PFS could predominantly be assigned to the categories "dosing/administration" and "ease of use". The first impression of the new MTX autoinjector was positive in 82% of physicians, 87% of nurses, and 76% of patients, respectively. The four most important features of the new MTX autoinjector were 2-step autoinjector mechanism (receiving a mean 14.1 to 18.1 chips of a total of 100 chips), small injection volume (9.7 to 11.7 chips), 10 different doses for dose flexibility (8.0 to 13.2 chips), and short injection time below 5 seconds (8.5 to 11.1 chips). Conclusion: Arguments for the use of MTX pens as opposed to PFS predominantly refer to dosing/administration and ease of use. The new button-free MTX autoinjector combines a number of advantageous features identified by the international survey. Plain Language Summary: Subcutaneous injection of methotrexate (MTX) is an option to treat patients with specific inflammatory diseases. A new MTX autoinjector with button-free activation of the injection and no need to build a skin fold was developed to address some of the reasons for non-adherence. The importance of specific needs of users as well as the relevance of features of the new MTX autoinjector are unknown. Therefore, a structured questionnaire was distributed to physicians, nurses and patients in Germany, France, and the United Kingdom. Illustrations and information about features of the new MTX autoinjector were distributed to the participants. The results of the study show that arguments for the use of MTX pens as opposed to prefilled syringes predominantly affect the categories dosing/administration and ease of use followed by safety/side effects. In addition, the study identified four main advantageous features of the new MTX autoinjector, ie simplicity due to the 2-step button-free autoinjector mechanism, the small injection volume, 10 different doses for dose flexibility, and the short injection time below 5 seconds. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Reactance Level

Author

Edwards, Christopher J., primary, Beutler, Larry E., additional, and Someah, Kathleen, additional

Published
2019
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46. Coping Style

Author

Beutler, Larry E., primary, Edwards, Christopher J., additional, Kimpara, Satoko, additional, and Miller, Kimberley, additional

Published
2019
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