655 results on '"Edwards, Katherine"'
Search Results
2. Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model
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Cisco, Lily A., Sipple, Matthew T., Edwards, Katherine M., Thornton, Charles A., and Lueck, John D.
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Calcium channels -- Analysis ,Myotonic dystrophy -- Drug therapy -- Patient outcomes ,Verapamil -- Dosage and administration ,Health care industry - Abstract
Myotonic dystrophy type 1 (DM1) involves misregulated alternative splicing for specific genes. We used exon or nucleotide deletion to mimic altered splicing of genes central to muscle excitation- contraction coupling in mice. Mice with forced skipping of exon 29 in the [Ca.sub.V]1.1 calcium channel combined with loss of ClC-1 chloride channel function displayed markedly reduced lifespan, whereas other combinations of splicing mimics did not affect survival. The [Ca.sup.2+]/[Cl.sup.- ] bi- channelopathy mice exhibited myotonia, weakness, and impairment of mobility and respiration. Chronic administration of the calcium channel blocker verapamil rescued survival and improved force generation, myotonia, and respiratory function. These results suggest that [Ca.sup.2+]/[Cl.sup.-] bi-channelopathy contributes to muscle impairment in DM1 and is potentially mitigated by common clinically available calcium channel blockers., Introduction Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder characterized by myotonia, progressive weakness, heart block, gastrointestinal dysmotility, predisposition to malignancy, and other symptoms (1). Survival is limited [...]
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- 2024
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3. Trastuzumab Deruxtecan for Treating HER2-Positive Unresectable or Metastatic Breast Cancer After Two or More Anti-HER2 Therapies: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
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Houten, Rachel, Fleeman, Nigel, Mahon, James, Chaplin, Marty, Edwards, Katherine, Beale, Sophie, Boland, Angela, Dundar, Yenal, Marsden, Ashley, Malik, Zafar, and Palmieri, Carlo
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- 2023
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4. A Novel Prescription Digital Therapeutic Option for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease
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Alkhouri, Naim, Edwards, Katherine, Berman, Mark, Finn, Heather, Escandon, Rafael, Lupinacci, Paul, Guthrie, Nicole, Coste, Angie, Topete, Jesus, and Noureddin, Mazen
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- 2024
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5. Upholding Multilingual Learners' Civil Rights under ESSA: State Education Agency Leaders and the Contextual Factors Shaping Their Work
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Hopkins, Megan, Weddle, Hayley, Castillo, Melissa, Costa, Jessica, Edwards, Katherine, Elliot, Sandra, Gautsch, Leslie, Lowenhaupt, Rebecca, and Salas, Veronica
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Purpose: Alongside the inequities surfaced by COVID-19, a confluence of demographic and policy-related shifts over the last few decades has elevated the education of multilingual learners (MLs) in state education agency (SEA) leaders' work. This study employs an ecological perspective to examine how SEA leaders promote social justice policy implementation in their efforts to uphold MLs' civil rights under the Every Student Succeeds Act (ESSA). Research Methods: Given its embeddedness in a research-practice partnership (RPP) that emphasizes integration of researchers' expertise with SEA leaders' real-world knowledge, the study employs a participatory research approach. Drawing on 23 semistructured interviews with SEA leaders and 20 hours of observations during RPP meetings, the authors engaged in an iterative analysis process involving coding, memoing, and extensive member checking. Findings: Findings show the dual roles that leaders played to uphold the spirit of civil rights law across local education agencies (LEAs) and within SEAs, and they highlight the structural, cultural, and political dynamics that operated to enable or constrain this work. The study also reveals that cross-state collaboration may be a powerful mechanism for upholding ML civil rights in ways that go beyond compliance toward transformation and social justice. Implications: Although ESSA expanded the role of the SEA in policy implementation, little attention has been given to supporting state-level organizational development. Our findings suggest the need to allocate resources to support SEA capacity development. Such support is ever more critical as state systems work to develop coherent and aligned supports in response to COVID-19-related disparities.
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- 2022
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6. Trends in Mathematics Specialist Literature: Analyzing Research Spanning Four Decades
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Baker, Courtney K., Saclarides, Evthokia Stephanie, Harbour, Kristin E., Hjalmarson, Margret A., Livers, Stefanie D., and Edwards, Katherine Comey
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For the past forty years, United States school districts have increasingly hired mathematics specialists to support the teaching and learning of mathematics. Despite the prevalence of this professional development structure, this is a relatively new research topic for the mathematics education field. In this paper, we report findings from an exploration of literature between 1981 and 2018 to examine the role of mathematics specialists (MSs). In particular, we examine: (1) MS positioning across research; (2) historical trends of school-based MS research; and (3) orientations of school-based MSs within research. Using the McGatha and Rigelman framework as an analytic lens, we found that beyond the positions identified in their framework (coach, intervention specialist, teacher), there were four additional MS positionings within the research (learner, other p-12 stakeholder, university stakeholder, unknown). Ultimately, we forward an expansion to the McGatha and Rigelman framework to include these new categories, as well as contextual descriptions and working definitions to support future research in more accurately and robustly capturing the ways in which MSs are investigated and reported on in research.
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- 2022
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7. Connecting the Dots from Professional Development to Student Learning
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Ellingson, Charlene L., Edwards, Katherine, Roehrig, Gillian H., Hoelscher, M. Clark, Haroldson, Rachelle A., and Dubinsky, Janet M.
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Following professional development (PD), implementation of contemporary topics into high school biology requires teachers to make critical decisions regarding integration of novel content into existing course scope and sequence. Often exciting topics, such as neuroscience, do not perfectly align with standards. Despite commitment to enacting what was learned in the PD, teachers must adapt novel content to their perceptions of good teaching, local context, prior knowledge of their students, and state and district expectations. How teachers decide to integrate curricula encountered from PD programs may affect student outcomes. This mixed-methods study examined the relationship between curricular application strategies following an inquiry-based neuroscience PD and student learning. Post-PD curricular implementation was measured qualitatively through analysis of teacher action plans and classroom observations and quantitatively using hierarchical linear modeling to determine the impact of implementation on student performance. Participation in neuroscience PD predicted improved student learning compared with control teachers. Of the two distinct curricular implementation strategies, enacting a full unit produced significantly greater student learning than integrating neuroscience activities into existing biology units. Insights from this analysis should inform teacher implementation of new curricula after PD on other contemporary biology topics.
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- 2021
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8. Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
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Edwards, Katherine, Kissenpfennig, Adrien, and Moynagh, Paul
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inflammation ,innate immunity ,klebsiella pneumoniae ,inflammasomes ,suppressor of cytokine signalling proteins ,SOCS proteins ,macrophages - Abstract
Inflammasomes are innate immune signalling complexes vital in the activation of caspase-1, inflammation and wound healing. The dysregulation of inflammasome activity has been linked to the development of autoinflammatory diseases. Recently, the role of post-translational modifications has been identified to play an important role in regulating inflammasome activity, in particular the process of ubiquitination. Therefore, it is of great value to identify ubiquitin ligases or complexes that may regulate inflammasome activity through ubiquitination. This study investigated the role of suppressor of cytokine signalling (SOCS) proteins, which promote proteasomal degradation through ubiquitination, in regulating inflammasome activity. In this study SOCS2 and SOCS3 deficiency did not impact the inflammatory response to inflammasome-activating stimuli, including the highly antibiotic-resistant and encapsulated bacterium Klebsiella pneumoniae (Kp), ex vivo and in vivo. This study employed two strains of Kp (Kp52145 and Kp43816) with differential expression of the capsule; Kp52145 has a thicker capsule than Kp43816. This study demonstrated the importance of the capsule in regulating immune responses as it was found that Kp43816 was more effective at colonising C57BL/6J mice and inducing an inflammatory response than Kp52415. Furthermore, Kp43816 induced a stronger inflammasome response and was phagocytosed more efficiently than Kp52415 by macrophages. The importance of inflammasome activity during Kp infection was investigated with the use of nucleotide-binding oligomerisation domain-like receptor 3 (NLRP3)- and caspase-1/11-deficient mice, in addition to the pharmacological inhibition of NLRP3 (with MCC950) and caspase (with z-VAD-FMK) activity. This study found that Kp activated the NLRP3 inflammasome, as well as other caspase-1/11-dependent and independent pathways that contributed to the production and secretion of IL-1β, but that these did not impact the bactericidal activity of macrophages. These findings demonstrated that multiple inflammasomes and inflammatory signalling pathways can detect Kp and induce an inflammatory immune response to promote the elimination of Kp.
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- 2020
9. Diagnostic accuracy and clinical impact of MRI-based technologies for patients with non-alcoholic fatty liver disease: systematic review and economic evaluation
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Bresnahan Rebecca, Duarte Rui, Mahon James, Beale Sophie, Chaplin Marty, Bhattacharyya Devarshi, Houten Rachel, Edwards Katherine, Nevitt Sarah, Maden Michelle, and Boland Angela
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biopsy ,cost-benefit analysis ,economic models ,humans ,inflammation ,liver cirrhosis ,magnetic resonance imaging ,non-alcoholic fatty liver disease ,routine diagnostic tests ,technology ,Medical technology ,R855-855.5 - Abstract
Background Magnetic resonance imaging-based technologies are non-invasive diagnostic tests that can be used to assess non-alcoholic fatty liver disease. Objectives The study objectives were to assess the diagnostic test accuracy, clinical impact and cost-effectiveness of two magnetic resonance imaging-based technologies (LiverMultiScan and magnetic resonance elastography) for patients with non-alcoholic fatty liver disease for whom advanced fibrosis or cirrhosis had not been diagnosed and who had indeterminate results from fibrosis testing, or for whom transient elastography or acoustic radiation force impulse was unsuitable, or who had discordant results from fibrosis testing. Data sources The data sources searched were MEDLINE, MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Database of Controlled Trials, Database of Abstracts of Reviews of Effects and the Health Technology Assessment. Methods A systematic review was conducted using established methods. Diagnostic test accuracy estimates were calculated using bivariate models and a summary receiver operating characteristic curve was calculated using a hierarchical model. A simple decision-tree model was developed to generate cost-effectiveness results. Results The diagnostic test accuracy review (13 studies) and the clinical impact review (11 studies) only included one study that provided evidence for patients who had indeterminate or discordant results from fibrosis testing. No studies of patients for whom transient elastography or acoustic radiation force impulse were unsuitable were identified. Depending on fibrosis level, relevant published LiverMultiScan diagnostic test accuracy results ranged from 50% to 88% (sensitivity) and from 42% to 75% (specificity). No magnetic resonance elastography diagnostic test accuracy data were available for the specific population of interest. Results from the clinical impact review suggested that acceptability of LiverMultiScan was generally positive. To explore how the decision to proceed to biopsy is influenced by magnetic resonance imaging-based technologies, the External Assessment Group presented cost-effectiveness analyses for LiverMultiScan plus biopsy versus biopsy only. Base-case incremental cost-effectiveness ratio per quality-adjusted life year gained results for seven of the eight diagnostic test strategies considered showed that LiverMultiScan plus biopsy was dominated by biopsy only; for the remaining strategy (Brunt grade ≥2), the incremental cost-effectiveness ratio per quality-adjusted life year gained was £1,266,511. Results from threshold and scenario analyses demonstrated that External Assessment Group base-case results were robust to plausible variations in the magnitude of key parameters. Limitations Diagnostic test accuracy, clinical impact and cost-effectiveness data for magnetic resonance imaging-based technologies for the population that is the focus of this assessment were limited. Conclusions Magnetic resonance imaging-based technologies may be useful to identify patients who may benefit from additional testing in the form of liver biopsy and those for whom this additional testing may not be necessary. However, there is a paucity of diagnostic test accuracy and clinical impact data for patients who have indeterminate results from fibrosis testing, for whom transient elastography or acoustic radiation force impulse are unsuitable or who had discordant results from fibrosis testing. Given the External Assessment Group cost-effectiveness analyses assumptions, the use of LiverMultiScan and magnetic resonance elastography for assessing non-alcoholic fatty liver disease for patients with inconclusive results from previous fibrosis testing is unlikely to be a cost-effective use of National Health Service resources compared with liver biopsy only. Study registration This study is registered as PROSPERO CRD42021286891. Funding Funding for this study was provided by the Evidence Synthesis Programme of the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 27, No. 10. See the NIHR Journals Library website for further project information. Plain language summary Non-alcoholic fatty liver disease includes a range of conditions that are caused by a build-up of fat in the liver, and not by alcohol consumption. This build-up of fat can cause inflammation. Persistent inflammation can cause scar tissue (fibrosis) to develop. It is important to identify patients with fibrosis because severe fibrosis can cause permanent liver damage (cirrhosis), which can lead to liver failure and liver cancer. In the National Health Service, patients with non-alcoholic fatty liver disease undergo tests to determine whether they have fibrosis. The test results are not always accurate and multiple tests can give conflicting results. Some of the tests may not be suitable for patients who have a very high body mass index. In the National Health Service, a liver biopsy may be offered to patients with inconclusive or conflicting test results or to those patients for whom other tests are unsuitable. However, liver biopsy is expensive, and is associated with side-effects such as pain and bleeding. Magnetic resonance imaging-based testing could be used as an extra test to help clinicians assess non-alcoholic fatty liver disease and identify patients who may need a liver biopsy. We assessed two magnetic resonance imaging-based diagnostic tests, LiverMultiScan and magnetic resonance elastography. LiverMultiScan is imaging software that is used alongside magnetic resonance imaging to measure markers of liver disease. Magnetic resonance elastography is used in some National Health Service centres to assess liver fibrosis; however, magnetic resonance elastography requires more equipment than just an magnetic resonance imaging scanner. We reviewed all studies examining how well LiverMultiScan and magnetic resonance elastography assess patients with non-alcoholic fatty liver disease. We also built an economic model to estimate the costs and benefits of using LiverMultiScan to identify patients who should be sent for a biopsy. Results from the model showed that LiverMultiScan may not provide good value for money to the National Health Service. Scientific summary Background Non-alcoholic fatty liver disease (NAFLD) is an umbrella term for a range of conditions caused by a build-up of fat in the liver that has not been caused by alcohol consumption. NAFLD covers a spectrum of histological lesions ranging from steatosis (simple fatty liver) to complex patterns of hepatocyte injury, inflammation and fibrosis. In the current National Health Service diagnostic pathway for staging fibrosis (based on guidelines and expert advice to NICE), patients with NAFLD (confirmed by ultrasound and liver aetiology screen) are referred for the fibrosis-4 (FIB-4), NAFLD fibrosis score (NFS) or enhanced liver fibrosis (ELF) test as first-line testing. Patients with an indeterminate result from first-line testing are referred for second-line testing using transient elastography (TE), acoustic radiation force impulse (ARFI) or the ELF test, if it had not already been used as a first-line test. Patients with indeterminate or discordant results from fibrosis testing and patients with high risk of advanced fibrosis are considered for liver biopsy. Magnetic resonance imaging (MRI)-based testing could be used as an additional, non-invasive, diagnostic test to help clinicians stage NAFLD and potentially identify which patients should be referred for liver biopsy. Liver biopsy is expensive and is an invasive procedure that is associated with complications. Objectives The objectives of this study were to assess the diagnostic test accuracy (DTA), the clinical impact and the cost-effectiveness of two non-invasive MRI-based technologies, namely LiverMultiScan and magnetic resonance elastography (MRE), for patients with NAFLD for whom advanced fibrosis or cirrhosis had not yet been diagnosed and who had indeterminate results from fibrosis testing, for whom TE or ARFI was unsuitable, or who had discordant results from fibrosis testing. To achieve the study objectives, the External Assessment Group (EAG): conducted a systematic literature review to evaluate the (1) DTA of MRI-based technologies for the assessment of fibrosis, inflammation, and steatosis for a patients with NAFLD for whom advanced fibrosis or cirrhosis had not yet been diagnosed, using liver biopsy as the reference standard, and (2) the clinical impact of MRI-based technologies conducted a systematic literature review to explore the cost-effectiveness of MRI-based technologies as diagnostic tools and built a de novo economic model to assess the cost-effectiveness of two diagnostic pathways, namely MRI-based technologies plus biopsy and liver biopsy. Methods: assessment of diagnostic test accuracy and clinical impact Electronic databases (MEDLINE, MEDLINE Epub Ahead of Print In-Process & Other Non-Indexed Citations, Embase, Cochrane Databases of Systematic Reviews, Cochrane Central Database of Controlled Trials, Database of Abstracts of Reviews of Effects, Health Technology Assessment Database) were searched from inception to 4 October 2021. Eligible studies assessed the DTA or clinical impact of LiverMultiScan or MRE for patients with NAFLD for whom advanced fibrosis or cirrhosis had not yet been diagnosed (who have indeterminate results from fibrosis testing, for whom TE or ARFI is unsuitable, or who have discordant results from fibrosis testing). Two reviewers independently screened the titles and abstracts of all reports identified through electronic database searches and of all full-text articles subsequently obtained for assessment. Data extraction and quality assessment were conducted by one reviewer and checked for agreement by a second reviewer. The methodological quality of the included DTA studies was assessed using the QUality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. The methodological quality of randomised controlled trials (RCTs) evaluating the clinical impact of MRI-based technologies was assessed using the Cochrane Risk of Bias 2.0 tool. The National Institute of Health study quality-assessment tools for cohort studies, case-control studies and before–after (pre-post) studies with no control group were used to assess risk of bias of included non-randomised studies. Qualitative studies were assessed using the Critical Appraisal Skills Programme (CASP) qualitative studies checklist. The sensitivity and specificity of each index test were summarised in forest plots. Where at least three studies provided both sensitivity and specificity data for a specific combination of index test, diagnosis of interest, and cut-off value, a bivariate random-effects meta-analysis to provide pooled estimates of sensitivity and specificity was considered. We did not perform bivariate meta-analyses where statistical heterogeneity between the studies (assessed by visually examining forest plots) was so great that pooled estimates of sensitivity and specificity would have been meaningless. Where at least three studies provided both sensitivity and specificity data for a specific combination of index test and diagnosis of interest, but used different cut-off values for the index test, we used a hierarchical model to estimate a summary receiver operating characteristic (ROC) curve. Methods: assessment of cost-effectiveness The EAG appended an economic evaluation-specific search filter to the clinical search strategies to identify published cost-effectiveness studies. In addition, two databases of economic publications [EconLit (EBSCO) and the cost-effectiveness analysis (CEA) registry] were searched from inception until 4 October 2021. The EAG developed a simple, flexible de novo model to estimate the cost-effectiveness of an MRI-based technologies plus biopsy pathway versus liver biopsy only pathway. Results The EAG searches of the electronic databases and reference lists of relevant studies and systematic reviews identified 4489 records (3331 unique records). Although all the identified studies for inclusion in the DTA, clinical impact and cost-effectiveness reviews included patients with NAFLD for whom advanced fibrosis or cirrhosis had not yet been diagnosed, only one study provided results for patients with NAFLD who had indeterminate or discordant results from fibrosis testing. No studies were identified that considered patients for whom TE or ARFI was unsuitable. Diagnostic test accuracy The EAG identified 13 studies (15 publications). Two studies (four publications) were evaluations of LiverMultiScan, 10 studies (10 publications) were evaluations of MRE, and one study (one publication) was an evaluation of LiverMultiScan and MRE. MRI-based technology: LiverMultiScan For the LiverMultiScan proton density fat fraction (PDFF) and LiverMultiScan iron-corrected T1 (cT1) outputs, 2 × 2 data were available from three studies. The EAG considers that the Eddowes 2018 study is the most relevant study to this assessment. Eddowes 2018 recruited patients who were scheduled for non-targeted liver biopsy to stage fibrosis after inconclusive non-invasive assessment of fibrosis or to make a diagnosis after a range of non-invasive tests had not confirmed a diagnosis. For diagnosis of fibrosis, estimates from Eddowes 2018 ranged from 50% to 88% for sensitivity and from 42% to 75% for specificity. Sensitivity and specificity values for fibrosis testing in Eddowes 2018 were consistently higher for LiverMultiScan cT1 than for LiverMultiScan PDFF. Data from three studies were included in the meta-analyses for LiverMultiScan. For advanced fibrosis (≥F3), the pooled sensitivity and specificity values were higher for LiverMultiScan cT1 [sensitivity = 60.2%, 95% confidence interval (CI): 50.9% to 68.8%; specificity = 65.4%, 95% CI 55.8% to 73.9%] than for LiverMultiScan PDFF (sensitivity = 38.6%, 95% CI 23.8% to 56.0%; specificity = 43.6%, 95% CI 30.7% to 57.5%). MRI-based technology: magnetic resonance elastography For the MRE test, 2 × 2 data were available from four studies. Estimates of sensitivity and specificity for advanced fibrosis (≥F3) were high and ranged from 71% to 100% and 79% to 93%, respectively. However, the cut-off values used to indicate a positive result from the index test varied between studies, therefore a summary ROC curve was estimated. The summary ROC curve indicates high DTA. However, observed study results do not all lie close to the summary ROC curve, which could be due to small sample sizes and/or clinical and methodological heterogeneity between the included studies. Clinical impact Eleven studies (14 publications) were included in the clinical impact review. Five studies (eight publications) were evaluations of LiverMultiScan and six studies (six publications) were evaluations of MRE. MRI-based technology: LiverMultiScan Two studies reported on the prognostic ability of LiverMultiScan cT1. However, neither study reported results specifically for the subpopulation of patients with NAFLD for whom advanced fibrosis or cirrhosis had not yet been diagnosed. One study reported that LiverMultiScan cT1 and LiverMultiScan PDFF could reduce the number of unnecessary biopsies for patients with non-NAFLD and NAFLD to diagnose non-alcoholic steatohepatitis (NASH) and fibrosis unrelated to NAFLD [EAG calculated odds ratio (OR) = 0.65, 95% CI 0.22 to 1.96] and for patients with no to mild fibrosis (F0 to F1) to diagnose significant fibrosis to cirrhosis (F2 to F4; EAG calculated OR = 0.59, 95% CI 0.18 to 1.89) when compared to standard of care. Three studies reported the test failure rate of LiverMultiScan for patients with all liver aetiologies. The test failure rate ranged from 5.3% to 7.6%. One study reported the test failure rate for LiverMultiScan for patients with NAFLD (5.6%). Acceptability of LiverMultiScan was reported in a qualitative study and was generally positive. MRI-based technology: magnetic resonance elastography Six studies reported the test failure rate of MRE for patients with all liver aetiologies. The test failure rate ranged from 0.0% to 7.6%. Three studies reported the test failure rate for MRE specifically for patients with NAFLD. The EAG performed a fixed-effects meta-analysis to obtain a pooled estimate of 4.2% (95% CI 2.5% to 6.2%) test failure rate for patients with NAFLD. Despite conducting additional targeted searches, the EAG did not identify any relevant studies that provided evidence of the clinical impact of MRI-based technologies for patients with NAFLD for whom advanced fibrosis or cirrhosis has not been diagnosed, for the remaining clinical impact outcomes listed in the final scope issued by NICE. Cost-effectiveness The EAG base-case incremental cost-effectiveness ratio (ICER) per quality-adjusted life year (QALY) gained results for seven of the eight diagnostic test strategies considered, and showed that the LiverMultiScan plus biopsy pathway was dominated by the biopsy only pathway. For Brunt grade ≥2, the ICER per QALY gained was £1,266,511. Results from the EAG threshold and scenario analyses demonstrated that these results were robust to plausible variations in the magnitude of key parameters. Conclusions The DTA, clinical impact and cost-effectiveness data for MRI-based technologies are limited for patients who have indeterminate results from fibrosis testing, for whom TE or ARFI is unsuitable or patients who have discordant results from fibrosis testing. Only one small LiverMultiScan study provided DTA and population prevalence data for patients described in the final scope issued by NICE. It is unclear whether sensitivity and specificity estimates reported by this small study will give clinicians sufficient confidence to use LiverMultiScan test results to triage patients with inconclusive results from previous fibrosis testing to biopsy. Cost-effectiveness results from the EAG model are only informative if clinicians have confidence in LiverMultiScan DTA data. Using the available DTA and population prevalence data, EAG cost-effectiveness results showed that LiverMultiScan is unlikely to be cost-effective at current prices when used to triage patients with inconclusive results from previous fibrosis testing to biopsy. LiverMultiScan data are not available for patients for whom TE or ARFI was unsuitable. Further, no MRE DTA data were available for the population described in the final scope issued by NICE. The EAG was unable to generate cost-effectiveness results for this technology; however, even if MRE was 100% accurate, due to high population prevalence estimates it is unlikely that MRE would be cost-effective at current prices. Study registration This study is registered as PROSPERO CRD42021286891. Funding Funding for this study was provided by the Evidence Synthesis Programme of the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 27, No. 10. See the NIHR Journals Library website for further project information.
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- 2023
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10. Reflections on Case Management—Past, Present, and Future
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Campagna, Vivian, primary, Edwards, Katherine, additional, and Morgan, Patricia Kelley, additional
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- 2024
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11. A qualitative exploration of the barriers and enablers to supporting informal and familial carers within community pharmacies.
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Richardson, Charlotte Lucy, Edwards, Katherine, Lunny, Judith, and Lindsey, Laura
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Objectives There are approximately 5.3 million informal carers in the United Kingdom, many of whom support family in their health despite being unpaid and often unsupported. Many visit pharmacies to collect medicines and look for advice. This work explores informal carer support within community pharmacies (CP). Methods Semi-structured video interviews exploring perspectives on the role of CP in supporting carers were conducted in autumn 2022. The study received institutional ethical approval. Interviews were audio-recorded, transcribed verbatim, and analysed using a reflexive thematic approach. Key findings In total 25 interviews were conducted with 13 carers and 12 pharmacy staff. Three themes were identified: -What support do carers need through CP?—medicines management, navigating services, and carers health and wellbeing. -Barriers to CP better supporting carers—relationships with CP, carer needs, identification as a 'carer'. -Enablers to CP better supporting carers—support is a team effort, and CP as a community 'hub'. Conclusions There is a trusted relationships between carers and pharmacy staff which can contribute to establishing pharmacies as a safe space of support, this includes medicines-specific support and navigating services, but also carer health and wellbeing support. Pharmacy staff may need to reconsider approaches to identifying and supporting carers and not just treating them as an extension of supporting a patient. In making this support accessible, relationships with pharmacy staff are important, as well as embracing CP as a 'community hub', although pharmacy staff may need training and information to facilitate them in this role. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Half-integral linkages in highly connected directed graphs
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Edwards, Katherine, Muzi, Irene, and Wollan, Paul
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Mathematics - Combinatorics ,Computer Science - Data Structures and Algorithms - Abstract
We study the half-integral $k$-Directed Disjoint Paths Problem ($\tfrac12$kDDPP) in highly strongly connected digraphs. The integral kDDPP is NP-complete even when restricted to instances where $k=2$, and the input graph is $L$-strongly connected, for any $L\geq 1$. We show that when the integrality condition is relaxed to allow each vertex to be used in two paths, the problem becomes efficiently solvable in highly connected digraphs (even with $k$ as part of the input). Specifically, we show that there is an absolute constant $c$ such that for each $k\geq 2$ there exists $L(k)$ such that $\tfrac12$kDDPP is solvable in time $O(|V(G)|^c)$ for a $L(k)$-strongly connected directed graph $G$. As the function $L(k)$ grows rather quickly, we also show that $\tfrac12$kDDPP is solvable in time $O(|V(G)|^{f(k)})$ in $(36k^3+2k)$-strongly connected directed graphs. We also show that for each $\epsilon<1$ deciding half-integral feasibility of kDDPP instances is NP-complete when $k$ is given as part of the input, even when restricted to graphs with strong connectivity $\epsilon k$., Comment: 20 pages
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- 2016
13. Experimental corticosterone manipulation increases mature feather corticosterone content: implications for inferring avian stress history from feather analyses
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Rotman, Yaara Aharon, Buttemer, William A., Koren, Lee, and Edwards, Katherine Wynne
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Birds -- Physiological aspects ,Feathers -- Physiological aspects ,Corticosterone -- Physiological aspects ,Stress (Physiology) -- Research ,Ornithological research ,Zoology and wildlife conservation - Abstract
Feathers incorporate circulating steroids during development. It is therefore assumed that the corticosterone (CORT) content of feathers ([CORT.sub.f]) represents an integrated measure of plasma CORT over the moult period. We tested this assumption by quantifying [CORT.sub.f] in feathers of House Sparrows (Passer domesticus (Linnaeus, 1758)) that were plucked before and after experimental manipulation of circulating CORT. Two of the seven flight feathers collected from each bird were fully grown throughout the CORT-manipulation period. We found that [CORT.sub.f] of all seven feathers corresponded with plasma CORT levels of non-moulting reference House Sparrows given the same implants. Surprisingly, the [CORT.sub.f] of the two mature feathers was 4- to 10-fold higher than values measured in the new replacement feathers. Our results show that [CORT.sub.f] of mature feathers may be affected by circulating CORT outside the moulting period. The most plausible explanation for our results is that CORT was transferred onto feather surfaces externally, but the mechanisms involved remain to be identified. Researchers are encouraged to establish effective procedures, in terms of both solvent and duration, for removing surface residues without extracting CORT from within the feather. This will increase confidence when inferring moult-related stress status from feather analyses in future ecological studies. Key words: feather, corticosterone, moult, glucocorticoid manipulation, mass spectrometry, House Sparrow, Passer domesticus. Les plumes incorporent des stéroïdes en circulation durant le développement. Il est donc présumé que la teneur en corticostérone (CORT) des plumes ([CORT.sub.f]) représente une mesure intégrée de la CORT plasmatique sur la durée de la période de mue. Nous avons vérifié cette hypothèse en quantifiant la [CORT.sub.f] dans des plumes de moineaux domestiques (Passer domesticus (Linnaeus, 1758)) prélevées avant et après une manipulation expérimentale de la CORT en circulation. La croissance de deux des sept pennes prélevées de chaque oiseau était terminée durant toute la période de manipulation de la CORT. Nous avons constaté que les [CORT.sub.f] des sept plumes correspondaient aux teneurs en CORT du plasma de moineaux domestiques témoins non en mue qui avaient reçu les mêmes implants. Etonnamment, les [CORT.sub.f] des deux pennes matures étaient de 4 à 10 fois plus grandes que les valeurs mesurées dans les nouvelles pennes. Nos résultats démontrent que la [CORT.sub.f] de plumes matures peut être influencée par la CORT en circulation en dehors dans la période de mue. L'explication la plus plausible de ces résultats est que de la CORT est transférée aux surfaces des plumes de manière externe, mais les mécanismes qui interviennent demeurent inconnus. Les chercheurs sont encouragés à établir des procédures concernant tant les solvants que la durée des manipulations visant à retirer les résidus superficiels sans extraire la CORT de l'intérieur des plumes. De telles procédures rehausseront le niveau de confiance d'estimations du stress associé à la mue basées sur l'analyse de plumes dans le cadre d'études écologiques futures. [Traduit par la Rédaction] Mots-clés : plume, corticostérone, mue, manipulation de glucocorticoïdes, spectrométrie de masse, moineau domestique, Passer domesticus., Introduction Corticosterone (CORT) is the main glucocorticoid hormone in birds and studies have shown that circulating CORT is incorporated into developing feathers via diffusion from the blood during cell differentiation [...]
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- 2021
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14. Sublethal, sex-specific, osmotic, and metabolic impairments in embryonic and adult round stingrays from a location exposed to environmental contamination in southern California, USA
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Lyons, Kady and Wynne-Edwards, Katherine E.
- Published
- 2021
- Full Text
- View/download PDF
15. Fast approximation algorithms for $p$-centres in large $\delta$-hyperbolic graphs
- Author
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Edwards, Katherine, Kennedy, W. Sean, and Saniee, Iraj
- Subjects
Computer Science - Data Structures and Algorithms ,Mathematics - Metric Geometry - Abstract
We provide a quasilinear time algorithm for the $p$-center problem with an additive error less than or equal to 3 times the input graph's hyperbolic constant. Specifically, for the graph $G=(V,E)$ with $n$ vertices, $m$ edges and hyperbolic constant $\delta$, we construct an algorithm for $p$-centers in time $O(p(\delta+1)(n+m)\log(n))$ with radius not exceeding $r_p + \delta$ when $p \leq 2$ and $r_p + 3\delta$ when $p \geq 3$, where $r_p$ are the optimal radii. Prior work identified $p$-centers with accuracy $r_p+\delta$ but with time complexity $O((n^3\log n + n^2m)\log(diam(G)))$ which is impractical for large graphs., Comment: 19 pages
- Published
- 2016
16. On paths, stars and wyes in trees
- Author
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Bubeck, Sébastien, Edwards, Katherine, Mania, Horia, and Supko, Cathryn
- Subjects
Mathematics - Combinatorics - Abstract
We further the study of local profiles of trees. Bubeck and Linial showed that the set of 5-profiles contains a certain polytope, namely the convex hull of d-millipedes, and they proved that the segment [0-millipede, 1-millipede] corresponds to a face of the set of 5-profiles. Our main result shows that the segment [1-millipede, 2-millipede] also corresponds to a face. Surprisingly we also show that for d > 3 the segment [d-millipede, (d+1)-millipede] is not a face of the set of 5-profiles. We do so by exhibiting new trees which are generalized millipedes with intriguing patterns for their degree sequence. The plot thickens, and the set of 5-profiles remains a mysterious convex set., Comment: 11 pages, 2 figures
- Published
- 2016
17. Examining the Impact of Later High School Start Times on the Health and Academic Performance of High School Students: A Multi-Site Study. Final Report
- Author
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University of Minnesota, Center for Applied Research and Educational Improvement (CAREI), Wahlstrom, Kyla L., Dretzke, Beverly J., Gordon, Molly F., Peterson, Kristin, Edwards, Katherine, and Gdula, Julie
- Abstract
The results from this three-year research study, conducted with over 9,000 students in eight public high schools in three states, reveal that high schools that start at 8:30 AM or later allow for more than 60% of students to obtain at least eight hours of sleep per school night. Teens getting less than eight hours of sleep reported significantly higher depression symptoms, greater use of caffeine, and are at greater risk for making poor choices for substance use. Academic performance outcomes, including grades earned in core subject areas of math, English, science and social studies, plus performance on state and national achievement tests, attendance rates and reduced tardiness show significantly positive improvement with the later start times of 8:35 AM or later. Finally, the number of car crashes for teen drivers from 16 to 18 years of age was significantly reduced by 70% when a school shifted start times from 7:35 AM to 8:55 AM. [Additional funding was provided by Teton County School District, Jackson Hole, WY.]
- Published
- 2014
18. Concentration of the number of solutions of random planted CSPs and Goldreich's one-way candidates
- Author
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Abbe, Emmanuel and Edwards, Katherine
- Subjects
Mathematics - Probability ,Computer Science - Computational Complexity - Abstract
This paper shows that the logarithm of the number of solutions of a random planted $k$-SAT formula concentrates around a deterministic $n$-independent threshold. Specifically, if $F^*_{k}(\alpha,n)$ is a random $k$-SAT formula on $n$ variables, with clause density $\alpha$ and with a uniformly drawn planted solution, there exists a function $\phi_k(\cdot)$ such that, besides for some $\alpha$ in a set of Lesbegue measure zero, we have $ \frac{1}{n}\log Z(F^*_{k}(\alpha,n)) \to \phi_k(\alpha)$ in probability, where $Z(F)$ is the number of solutions of the formula $F$. This settles a problem left open in Abbe-Montanari RANDOM 2013, where the concentration is obtained only for the expected logarithm over the clause distribution. The result is also extended to a more general class of random planted CSPs; in particular, it is shown that the number of pre-images for the Goldreich one-way function model concentrates for some choices of the predicates., Comment: 17 pages
- Published
- 2015
19. Disjoint dijoins
- Author
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Chudnovsky, Maria, Edwards, Katherine, Kim, Ringi, Scott, Alex, and Seymour, Paul
- Subjects
Mathematics - Combinatorics - Abstract
A dijoin in a digraph is a set of edges meeting every directed cut. D. R. Woodall conjectured in 1976 that if G is a digraph, and every directed cut of G has at least k edges, then there are k pairwise disjoint dijoins. This remains open, but a capacitated version is known to be false. In particular, A. Schrijver gave a digraph G and a subset S of its edge-set, such that every directed cut contains at least two edges in S, and yet there do not exist two disjoint dijoins included in S. In Schrijver's example, G is planar, and the subdigraph formed by the edges in S consists of three disjoint paths. We conjecture that when k = 2, the disconnectedness of S is crucial: more precisely, that if G is a digraph, and S is a subset of the edges of G that forms a connected subdigraph (as an undirected graph), and every directed cut of G contains at least two edges in S, then we can partition S into two dijoins. We prove this in two special cases: when G is planar, and when the subdigraph formed by the edges in S is a subdivision of a caterpillar.
- Published
- 2014
20. Three-edge-colouring doublecross cubic graphs
- Author
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Edwards, Katherine, Sanders, Daniel P., Seymour, Paul, and Thomas, Robin
- Subjects
Mathematics - Combinatorics - Abstract
A graph is apex if there is a vertex whose deletion makes the graph planar, and doublecross if it can be drawn in the plane with only two crossings, both incident with the infinite region in the natural sense. In 1966, Tutte conjectured that every two-edge-connected cubic graph with no Petersen graph minor is three-edge-colourable. With Neil Robertson, two of us showed that this is true in general if it is true for apex graphs and doublecross graphs. In another paper, two of us solved the apex case, but the doublecross case remained open. Here we solve the doublecross case; that is, we prove that every two-edge-connected doublecross cubic graph is three-edge-colourable. The proof method is a variant on the proof of the four-colour theorem., Comment: 16 pages, 1 figure, 1 appendix. Three results in this paper are proved using computers. Please see version 1 for the computer programs and associated data
- Published
- 2014
21. A novel prescription digital therapeutic option for the treatment of metabolic dysfunction-associated steatotic liver disease
- Author
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Alkhouri, Naim, primary, Edwards, Katherine, additional, Berman, Mark, additional, Finn, Heather, additional, Escandon, Rafael, additional, Lupinacci, Paul, additional, Guthrie, Nicole, additional, Coste, Angie, additional, Topete, Jesus, additional, and Noureddin, Mazen, additional
- Published
- 2023
- Full Text
- View/download PDF
22. B - 95 A Case Study of Suspected Klein-Levin Syndrome and Associated Anxiety
- Author
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Mullins, Teagan, primary, Hernandez-Vallant, Alexandra, additional, Burks, Alexis, additional, Edwards, Katherine, additional, Shendo, Macaiah, additional, Decruz-Dixon, Naila, additional, Gillezeau, Christina, additional, Schodt, Kaitlyn, additional, and Abrams-Silva, Lynette, additional
- Published
- 2023
- Full Text
- View/download PDF
23. H - 27 TBI and PTSD in an Indigenous Patient: It’s Complicated
- Author
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Burks, Alexis, primary, Solis, Isabel, additional, Shendo, Macaiah, additional, Decruz-Dixon, Naila, additional, Edwards, Katherine, additional, Gillezeau, Christina, additional, Hernandez-Vallant, Alex, additional, Mullins, Teagan, additional, Schodt, Kaitlyn, additional, and Abrams-Silva, Lynette, additional
- Published
- 2023
- Full Text
- View/download PDF
24. Derivation and independent validation of kidneyintelX.dkd: A prognostic test for the assessment of diabetic kidney disease progression
- Author
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Nadkarni, Girish N., primary, Stapleton, Sharon, additional, Takale, Dipti, additional, Edwards, Katherine, additional, Moran, Kara, additional, Mosoyan, Gohar, additional, Hansen, Michael K., additional, Donovan, Michael J., additional, Heerspink, Hiddo J. L., additional, Fleming, Fergus, additional, and Coca, Steven G., additional
- Published
- 2023
- Full Text
- View/download PDF
25. A relative of Hadwiger's conjecture
- Author
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Edwards, Katherine, Kang, Dong Yeap, Kim, Jaehoon, Oum, Sang-il, and Seymour, Paul
- Subjects
Mathematics - Combinatorics ,05C83, 05C15 - Abstract
Hadwiger's conjecture asserts that if a simple graph $G$ has no $K_{t+1}$ minor, then its vertex set $V(G)$ can be partitioned into $t$ stable sets. This is still open, but we prove under the same hypotheses that $V(G)$ can be partitioned into $t$ sets $X_1,\ldots, X_t$, such that for $1\le i\le t$, the subgraph induced on $X_i$ has maximum degree at most a function of $t$. This is sharp, in that the conclusion becomes false if we ask for a partition into $t-1$ sets with the same property., Comment: 6 pages
- Published
- 2014
- Full Text
- View/download PDF
26. Extension from Precoloured Sets of Edges
- Author
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Edwards, Katherine, Girão, António, Heuvel, Jan van den, Kang, Ross J., Puleo, Gregory J., and Sereni, Jean-Sébastien
- Subjects
Mathematics - Combinatorics ,05C15 - Abstract
We consider precolouring extension problems for proper edge-colourings of graphs and multigraphs, in an attempt to prove stronger versions of Vizing's and Shannon's bounds on the chromatic index of (multi)graphs in terms of their maximum degree $\Delta$. We are especially interested in the following question: when is it possible to extend a precoloured matching to a colouring of all edges of a (multi)graph? This question turns out to be related to the notorious List Colouring Conjecture and other classic notions of choosability., Comment: 26 pages, 3 figures, 1 table; in v2, two co-authors added, main conjecture weakened, weak version of conjecture proved, planar section updated; v3 accepted to Electronic Journal of Combinatorics
- Published
- 2014
27. Sex differences in substrates and clearance products of cortisol and corticosterone synthesis in full-term human umbilical circulation without labor: Substrate depletion matches synthesis in males, but not females
- Author
-
Wynne-Edwards, Katherine E., Lee, Kovid, Zhou, Ruokun, and Edwards, Heather E.
- Published
- 2019
- Full Text
- View/download PDF
28. The effect of prescribed exercise volume on biomarkers of chronic stress in postmenopausal women: Results from the Breast Cancer and Exercise Trial in Alberta (BETA)
- Author
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Friedenreich, Christine M., Wang, Qinggang, Shaw, Eileen, Heer, Emily V., Zhou, Ruokun, Brenner, Darren R., Courneya, Kerry S., and Wynne-Edwards, Katherine E.
- Published
- 2019
- Full Text
- View/download PDF
29. Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice
- Author
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Rodriguez-Sosa, Jose R, Bondareva, Alla, Tang, Lin, Avelar, Gleide F, Coyle, Krysta M, Modelski, Mark, Alpaugh, Whitney, Conley, Alan, Wynne-Edwards, Katherine, França, Luiz R, Meyers, Stuart, and Dobrinski, Ina
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Contraception/Reproduction ,Urologic Diseases ,Animals ,Apoptosis ,Cell Differentiation ,Dibutyl Phthalate ,Diethylhexyl Phthalate ,Environmental Exposure ,Female ,Germ Cells ,Inhibins ,Leydig Cells ,Macaca mulatta ,Male ,Mice ,Mice ,SCID ,Pregnancy ,Prenatal Exposure Delayed Effects ,Seminiferous Tubules ,Sertoli Cells ,Spermatogonia ,Testis ,Transplantation ,Heterologous ,Phthalates ,Testis development ,Steroidogenesis ,Spermatogenesis ,Non-human primates ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biochemistry and cell biology ,Genetics ,Clinical sciences - Abstract
Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcutaneously to immune-deficient mice, which were exposed to 0, 10, or 500 mg/kg of DBP or DEHP for 14 weeks or 28 weeks (DBP only). DBP exposure reduced the expression of key steroidogenic genes, indicating that Leydig cell function was compromised. Exposure to 500 mg/kg impaired tubule formation and germ cell differentiation and reduced numbers of spermatogonia. Exposure to 10 mg/kg did not affect development, but reduced Sertoli cell number and resulted in increased expression of inhibin B. Exposure to DEHP for 14 week also affected steroidogenic genes expression. Therefore, long-term exposure to phthalate esters affected development and function of the primate testis in a time and dosage dependent manner.
- Published
- 2014
30. Edge-colouring seven-regular planar graphs
- Author
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Chudnovsky, Maria, Edwards, Katherine, Kawarabayashi, Ken-ichi, and Seymour, Paul
- Subjects
Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
A conjecture due to the fourth author states that every $d$-regular planar multigraph can be $d$-edge-coloured, provided that for every odd set $X$ of vertices, there are at least $d$ edges between $X$ and its complement. For $d = 3$ this is the four-colour theorem, and the conjecture has been proved for all $d\le 8$, by various authors. In particular, two of us proved it when $d=7$; and then three of us proved it when $d=8$. The methods used for the latter give a proof in the $d=7$ case that is simpler than the original, and we present it here., Comment: 23 pages. arXiv admin note: substantial text overlap with arXiv:1209.1176
- Published
- 2012
31. Edge-colouring eight-regular planar graphs
- Author
-
Chudnovsky, Maria, Edwards, Katherine, and Seymour, Paul
- Subjects
Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
It was conjectured by the third author in about 1973 that every $d$-regular planar graph (possibly with parallel edges) can be $d$-edge-coloured, provided that for every odd set $X$ of vertices, there are at least $d$ edges between $X$ and its complement. For $d = 3$ this is the four-colour theorem, and the conjecture has been proved for all $d\le 7$, by various authors. Here we prove it for $d = 8$., Comment: 31 pages
- Published
- 2012
32. Quantitative meta-analysis of maternal prenatal salivary cortisol and newborn birthweight does not identify effect of fetal sex
- Author
-
Cherak, Stephana J., Malebranche, Mary E., Wynne-Edwards, Katherine, Williamson, Tyler, and Giesbrecht, Gerald F.
- Published
- 2019
- Full Text
- View/download PDF
33. Aerobic exercise increases cortisol awakening response in older adults
- Author
-
Drogos, Lauren L., Wynne-Edwards, Katherine, Zhou, Ruokun, Hall, Samantha E., Tyndall, Amanda V., Longman, R. Stewart, Eskes, Gail, and Poulin, Marc J.
- Published
- 2019
- Full Text
- View/download PDF
34. A superlocal version of Reed's Conjecture
- Author
-
Edwards, Katherine and King, Andrew D.
- Subjects
Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
Reed's well-known $\omega$, $\Delta$, $\chi$ conjecture proposes that every graph satisfies $\chi \leq \lceil \frac 12(\Delta+1+\omega)\rceil$. The second author formulated a {\em local strengthening} of this conjecture that considers a bound supplied by the neighbourhood of a single vertex. Following the idea that the chromatic number cannot be greatly affected by any particular stable set of vertices, we propose a further strengthening that considers a bound supplied by the neighbourhoods of two adjacent vertices. We provide some fundamental evidence in support, namely that the stronger bound holds in the fractional relaxation and holds for both quasi-line graphs and graphs with stability number two. We also conjecture that in the fractional version, we can push the locality even further., Comment: 17 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1109.2112
- Published
- 2012
35. Bounding the fractional chromatic number of $K_\Delta$-free graphs
- Author
-
Edwards, Katherine and King, Andrew D.
- Subjects
Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
King, Lu, and Peng recently proved that for $\Delta\geq 4$, any $K_\Delta$-free graph with maximum degree $\Delta$ has fractional chromatic number at most $\Delta-\tfrac{2}{67}$ unless it is isomorphic to $C_5\boxtimes K_2$ or $C_8^2$. Using a different approach we give improved bounds for $\Delta\geq 6$ and pose several related conjectures. Our proof relies on a weighted local generalization of the fractional relaxation of Reed's $\omega$, $\Delta$, $\chi$ conjecture., Comment: 30 pages, revised edition
- Published
- 2012
36. A note on hitting maximum and maximal cliques with a stable set
- Author
-
Christofides, Demetres, Edwards, Katherine, and King, Andrew D.
- Subjects
Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
It was recently proved that any graph satisfying $\omega > \frac 23(\Delta+1)$ contains a stable set hitting every maximum clique. In this note we prove that the same is true for graphs satisfying $\omega \geq \frac 23(\Delta+1)$ unless the graph is the strong product of $K_{\omega/2}$ and an odd hole. We also provide a counterexample to a recent conjecture on the existence of a stable set hitting every sufficiently large maximal clique., Comment: 7 pages, two figures, accepted to J. Graph Theory
- Published
- 2011
37. Sensation-Seeking and Impulsivity in Athletes with Sport-Related Concussion
- Author
-
Liebel, Spencer W., Edwards, Katherine A. M., and Broglio, Steven P.
- Published
- 2021
- Full Text
- View/download PDF
38. Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child
- Author
-
Bromley, Rebecca, additional, Adab, Naghme, additional, Bluett-Duncan, Matt, additional, Clayton-Smith, Jill, additional, Christensen, Jakob, additional, Edwards, Katherine, additional, Greenhalgh, Janette, additional, Hill, Ruaraidh A, additional, Jackson, Cerian F, additional, Khanom, Sonia, additional, McGinty, Ronan N, additional, Tudur Smith, Catrin, additional, Pulman, Jennifer, additional, and Marson, Anthony G, additional
- Published
- 2023
- Full Text
- View/download PDF
39. Calcium Hydroxylapatite-Induced Inflammatory Facial Edema and Induration Due to Hashimoto’s Thyroiditis
- Author
-
Verma, Kritin K, primary, Edwards, Katherine A, additional, and Friedmann, Daniel P, additional
- Published
- 2023
- Full Text
- View/download PDF
40. A novel prescription digital therapeutic for the treatment of non-alcohol related fatty liver disease: feasibility study
- Author
-
Alkhouri, Naim, primary, Edwards, Katherine, additional, Berman, Mark, additional, Rudolf, Erin, additional, Finn, Heather, additional, Dusky, Heidi, additional, Guthrie, Nicole, additional, Escandon, Rafael, additional, Coste, Angie, additional, Topete, Jesus, additional, and Noureddin, Mazen, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Combinatorial chloride and calcium channelopathy in myotonic dystrophy
- Author
-
Cisco, Lily A., Sipple, Matthew T., Edwards, Katherine M., Thornton, Charles A., and Lueck, John D.
- Subjects
Article - Abstract
Myotonic dystrophy type 1 (DM1) involves misregulated alternative splicing for specific genes. We used exon or nucleotide deletion to mimic altered splicing of genes central to muscle excitation-contraction coupling processes in mice. Mice with forced-skipping of exon 29 in Ca (V) 1.1 calcium channel combined with loss of ClC-1 chloride channel function showed a markedly reduced lifespan, whereas other combinations of splicing mimics did not affect survival. The Ca (2+) /Cl (-) bi-channelopathy mice exhibited myotonia, weakness, and impairment of mobility and respiration. Chronic administration of the calcium channel blocker verapamil rescued survival and improved force generation, myotonia, and respiratory function. These results suggest that Ca (2+) /Cl (-) bi-channelopathy contributes to muscle impairment in DM1 and is potentially mitigated by common clinically available calcium channel blockers. SUMMARY: Repurposing of a calcium channel blocker extends life and mitigates muscle and respiratory dysfunction in a myotonic dystrophy type 1 Ca (2+) /Cl (-) bi-channelopathy mouse model.
- Published
- 2023
42. Fast Approximation Algorithms for p-Centers in Large δ-Hyperbolic Graphs
- Author
-
Edwards, Katherine, Kennedy, W. Sean, and Saniee, Iraj
- Published
- 2018
- Full Text
- View/download PDF
43. Forward through history : a critical study of the work of Chris Offutt
- Author
-
Edwards, Katherine E. and Millard, Ken
- Subjects
810 ,Literature - Published
- 2008
44. PO-01-054 IDENTIFYING RESOURCES TO OVERCOME BARRIERS THAT REDUCE ACTIVITY ENGAGEMENT IN INDIVIDUALS WITH ICDS
- Author
-
Ottoboni, Linda K., primary, Lau, Crystaljade, additional, Sears-Edwards, Katherine, additional, Hoover, Valerie, additional, and Wang, Paul J., additional
- Published
- 2023
- Full Text
- View/download PDF
45. Progesterone Receptors Mediate Male Aggression toward Infants
- Author
-
Schneider, Johanna S., Stone, Marielle K., Wynne-Edwards, Katherine E., Horton, Teresa H., Lydon, John, O'Malley, Bert, and Levine, Jon E.
- Published
- 2003
46. Fast Approximation Algorithms for p-centers in Large -hyperbolic Graphs
- Author
-
Edwards, Katherine, Kennedy, Sean, Saniee, Iraj, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Bonato, Anthony, editor, Graham, Fan Chung, editor, and Prałat, Paweł, editor
- Published
- 2016
- Full Text
- View/download PDF
47. Evolutionary Biology of Plant Defenses against Herbivory and Their Predictive Implications for Endocrine Disruptor Susceptibility in Vertebrates
- Author
-
Wynne-Edwards, Katherine E.
- Published
- 2001
- Full Text
- View/download PDF
48. Parental Behavior and Hormones in Mammals
- Author
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Wynne-Edwards, Katherine E., primary and Weil, Zachary M., additional
- Published
- 2019
- Full Text
- View/download PDF
49. GLOBE Study Culture Clusters: Can They Be Found in Importance Ratings of Managerial Competencies?
- Author
-
Clark, Jeremy Michael, Quast, Louis N., Jang, Soebin, Wohkittel, Joseph, Center, Bruce, Edwards, Katherine, and Bovornusvakool, Witsinee
- Abstract
Purpose: The purpose of this study is to explore patterns of importance ratings of managerial competencies in 22 countries in different regions around the globe, to guide specificity in assessing and developing managers in multiple geographies. Additionally, this study examined the utility of clustering countries based on shared culture, as defined by House "et al." (2004), to determine whether such clustering aids in interpreting and acting on any differences identified. Design/methodology/approach: The PROFILOR® for Managers contains 135 behavioral items, grouped into 24 competency scales. The instrument was developed from a review of the management and psychology literatures, exhaustive analysis of a large database (Sevy "et al.," 1985), job analysis questionnaires and interviews of hundreds of managers representing many functional areas and most major industries. Findings: Results suggest that clustering countries together for the purpose of providing prescriptive guidance for the development of individuals planning expatriate assignments does not clarify such guidance; in fact, it masks unique differences in competency priorities as measured on a country-by-country basis. Research limitations/implications: The participants for this study come from mid- to large-size organizations in 22 countries around the world. The organizations represented sought out management consulting services from a large, highly respected private-sector consultancy. As such, these findings are likely to be generalizable to managers from similar organizations. No attempt has been made to generalize these findings to entrepreneurial start-ups, small local organizations or organizations not inclined to seek Western-style management consulting services. Originality/value: This study is one of the first to examine the effectiveness of the GLOBE clusters as they relate to managerial competencies in multicultural workforces.
- Published
- 2016
- Full Text
- View/download PDF
50. Testosterone-Induced Male Traits in Female Ruffs (Philomachus pugnax): Autosomal Inheritance and Gender Differentiation
- Author
-
Lank, David B., Coupe, Malcolm, and Wynne-Edwards, Katherine E.
- Published
- 1999
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