611,422 results on '"Edwards, OR"'
Search Results
2. What's Old Is New? School Openings, Closings, and Student Achievement. Technical Report
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National Center for Research on Education Access and Choice (REACH), Danielle Sanderson Edwards, and Joshua Cowen
- Abstract
This study examines how student achievement changes following a transfer to a newly opened school. Using comprehensive data on students and teachers from Michigan schools that opened or closed between the 2010-11 and 2018-19 school years, the study employs event study models to evaluate changes in student outcomes as the local supply of schools evolves. The analysis reveals initial disruptive effects of transferring to a new school, particularly in math and English/Language Arts, with achievement levels recovering over a three-year period. These findings highlight the need to consider the high financial costs of school construction and maintenance alongside equity and opportunity concerns, given that students of color and lower-income students are disproportionately represented among those attending newly opened schools. The study includes discussions on the resource allocation and equity implications of these results, with supplemental data on school openings, closures, and their contextual impact.
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- 2024
3. Relativistic Quantum Kinetic Theory: Higher order contributions in assisted Schwinger pair production
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Edwards, James P., Ahmadiniaz, Naser, Schmidt, Sebastian M., and Kohlfürst, Christian
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High Energy Physics - Phenomenology - Abstract
Quantum kinetic theory is an important tool for studying non-equilibrium, non-perturbative and non-linear interactions within an open quantum system, and as such is able to provide an unprecedented view on particle production in the relativistic, ultra-high intensity regime of quantum electrodynamics. By re-organising the relativistic quantum transport equations for Abelian plasmas and integrating them with a perturbative expansion, we significantly expand the scope for kinetic theories to further elucidate the peculiarities of particle production at a spectral level. Keywords: Assisted Schwinger effect, Strong-field quantum electrodynamics, relativistic quantum transport, quantum kinetic theory, non-equilibrium quantum many-body physics., Comment: 5 pages + 9 pages of bibliography and supplement
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- 2025
4. Bolide infrasound signal morphology and yield estimates: A case study of two events detected by a dense acoustic sensor network
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Wilson, Trevor C., Silber, Elizabeth A., Colston, Thomas A., Elbing, Brian R., and Edwards, Thom R.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Atmospheric and Oceanic Physics ,Physics - Geophysics ,Physics - Instrumentation and Detectors ,Physics - Space Physics - Abstract
Two bolides (2 June 2016 and 4 April 2019) were detected at multiple regional infrasound stations with many of the locations receiving multiple detections. Analysis of the received signals was used to estimate the yield, location and trajectory, and the type of shock that produced the received signal. The results from the infrasound analysis were compared with ground truth information that was collected through other sensing modalities. This multi-modal framework offers an expanded perspective on the processes governing bolide shock generation and propagation. The majority of signal features showed reasonable agreement between the infrasound-based interpretation and the other observational modalities, though the yield estimate from the 2019 bolide was significantly lower using the infrasound detections. There was also evidence suggesting that one of the detections was from a cylindrical shock that was initially propagating upward, which is unusual though not impossible., Comment: 37 pages, 10 figures, 4 tables
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- 2025
5. Probing the sensitivity of semi-visible jets to current LHC measurements using the CONTUR toolkit
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Buckley, Andy, Butterworth, Jon, Corpe, Louie, Doglioni, Caterina, Kar, Deepak, Prat, Clarisse, Sinha, Sukanya, and Wilson-Edwards, Danielle
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High Energy Physics - Phenomenology - Abstract
Semi-visible jets arise from a hypothetical, strongly interacting ``dark sector'' -- a dark counterpart of quantum chromodynamics whose partial decays back to Standard Model particles introduce new types of collider BSM signature. CMS and ATLAS have have searched for semi-visible jets in the resonant and non-resonant production modes and set constraints on mediator mass values. In this work, indirect constraints on various model parameters, such as dark hadron masses and coupling strengths, are explored using LHC measurements.
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- 2025
6. Searching for Hot Water World Candidates with CHEOPS: Refining the radii and analysing the internal structures and atmospheric lifetimes of TOI-238 b and TOI-1685 b
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Egger, J. A., Kubyshkina, D., Alibert, Y., Osborn, H. P., Bonfanti, A., Wilson, T. G., Brandeker, A., Günther, M. N., Lendl, M., Kitzmann, D., Fossati, L., Mordasini, C., Sousa, S. G., Adibekyan, V., Fridlund, M., Pezzotti, C., Gandolfi, D., Ulmer-Moll, S., Alonso, R., Bárczy, T., Navascues, D. Barrado, Barros, S. C., Baumjohann, W., Benz, W., Billot, N., Borsato, L., Broeg, C., Cameron, A. Collier, Correia, A. C. M., Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. -O., Derekas, A., Edwards, B., Ehrenreich, D., Erikson, A., Fortier, A., Gazeas, K., Gillon, M., Güdel, M., Heitzmann, A., Helling, Ch., Isaak, K. G., Kiss, L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Luntzer, A., Luque, R., Magrin, D., Maxted, P. F. L., Merín, B., Munari, M., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Southworth, R., Stalport, M., Sulis, S., Szabó, M. Gy., Udry, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., Wolf, S., and Wolter, D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Studying the composition of exoplanets is one of the most promising approaches to observationally constrain planet formation and evolution processes. However, this endeavour is complicated for small exoplanets by the fact that a wide range of compositions is compatible with their bulk properties. To overcome this issue, we identify triangular regions in the mass-radius space where part of this degeneracy is lifted for close-in planets, since low-mass H/He envelopes would not be stable due to high-energy stellar irradiation. Planets in these Hot Water World triangles need to contain at least some heavier volatiles and are therefore interesting targets for atmospheric follow-up observations. We perform a demographic study to show that only few well-characterised planets in these regions are currently known and introduce our CHEOPS GTO programme aimed at identifying more of these potential hot water worlds. Here, we present CHEOPS observations for the first two targets of our programme, TOI-238 b and TOI-1685 b. Combined with TESS photometry and published RVs, we use the precise radii and masses of both planets to study their location relative to the corresponding Hot Water World triangles, perform an interior structure analysis and study the lifetimes of H/He and water-dominated atmospheres under these conditions. We find that TOI-238 b lies, at the 1-sigma level, inside the corresponding triangle. While a pure H/He atmosphere would have evaporated after 0.4-1.3 Myr, it is likely that a water-dominated atmosphere would have survived until the current age of the system, which makes TOI-238 b a promising hot water world candidate. Conversely, TOI-1685 b lies below the mass-radius model for a pure silicate planet, meaning that even though a water-dominated atmosphere would be compatible both with our internal structure and evaporation analysis, we cannot rule out the planet to be a bare core., Comment: 25 pages, 16 figures, accepted for publication in A&A
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- 2025
7. Development of Radar and Optical Tracking of Near-Earth Asteroids at the University of Tasmania
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White, Oliver James, Calvés, Guifré Molera, Horiuchi, Shinji, Giorgini, Jon, Stacy, Nick, Cole, Andrew, Phillips, Chris, Edwards, Phil, Kruzins, Ed, Stevens, Jamie, Benner, Lance, and Peters, Edwin
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Space Physics - Abstract
We detail the use of the University of Tasmania's (UTAS) optical and radio telescopes to conduct observations of near-Earth asteroids from 2021 to 2024. The Canberra Deep Space Communication Complex transmitted a radio signal at 7159.45 MHz, with the radar echo detected by the UTAS radio telescopes. The method of accounting for the Doppler shift between the stations and the near-Earth object is described so that others can implement a similar program. We present our results, with confirmed detections of 1994 PC1 and 2003 UC20 asteroids using the Hobart and Katherine 12-m antennas, demonstrating the feasibility of using small radio telescopes for these observations. Additionally, the recently upgraded Ceduna 30 m antenna was used to detect 2024 MK. Data collected from other observatories, such as Tidbinbilla, as well as the UTAS radar tracking of the moon are also presented in the context of demonstrating the means of applying these Doppler corrections and the accuracy of each method. Optical observations conducted in this period are also detailed as they complement radar observations and aid in refining the orbit parameters., Comment: 21 pages, 16 figures, published in Remote Sensing
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- 2025
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8. Impact of phase signal formulations on tilt-to-length coupling noise in the LISA test mass interferometer
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Edwards, Paul, Dave, Megha, Weaver, Alexander, Zhao, Mengyuan, Fulda, Paul, Mueller, Guido, and Wanner, Gudrun
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Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology - Abstract
Tilt-to-length (TTL) coupling in the Laser Interferometer Space Antenna (LISA) can generate spurious displacement noise that potentially affects the measurement of gravitational wave signals. In each test mass interferometer, the coupling of misalignments with spacecraft angular jitter produces noise in the longitudinal pathlength signal. This signal comes from the phase readout combinations of an interfering measurement beam and a local reference beam at a quadrant photodetector, but various formulations exist for its calculation. Selection of this pathlength signal formulation affects the TTL coupling noise. We therefore simulated two pathlength signal candidates, the complex sum and the averaged phase, and evaluated their performance in the LISA test mass interferometer under the assumption of static alignment imperfections. All simulations were performed using three different methods with cross-checked results. We find with all three methods that the averaged phase is the choice with equal or less TTL coupling noise in four out of the five test cases. Finally, we show that the non-linear TTL contributions in the test mass interferometer to be negligible in all our test-cases, no matter which formulation of pathlength signal is chosen., Comment: 34 pages, 25 figures
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- 2025
9. No Foundations without Foundations -- Why semi-mechanistic models are essential for regulatory biology
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Kovačević, Luka, Gaudelet, Thomas, Opzoomer, James, Triendl, Hagen, Whittaker, John, Uhler, Caroline, Edwards, Lindsay, and Taylor-King, Jake P.
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Computer Science - Machine Learning - Abstract
Despite substantial efforts, deep learning has not yet delivered a transformative impact on elucidating regulatory biology, particularly in the realm of predicting gene expression profiles. Here, we argue that genuine "foundation models" of regulatory biology will remain out of reach unless guided by frameworks that integrate mechanistic insight with principled experimental design. We present one such ground-up, semi-mechanistic framework that unifies perturbation-based experimental designs across both in vitro and in vivo CRISPR screens, accounting for differentiating and non-differentiating cellular systems. By revealing previously unrecognised assumptions in published machine learning methods, our approach clarifies links with popular techniques such as variational autoencoders and structural causal models. In practice, this framework suggests a modified loss function that we demonstrate can improve predictive performance, and further suggests an error analysis that informs batching strategies. Ultimately, since cellular regulation emerges from innumerable interactions amongst largely uncharted molecular components, we contend that systems-level understanding cannot be achieved through structural biology alone. Instead, we argue that real progress will require a first-principles perspective on how experiments capture biological phenomena, how data are generated, and how these processes can be reflected in more faithful modelling architectures., Comment: 19 pages, 8 figures
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- 2025
10. An AI-Driven Live Systematic Reviews in the Brain-Heart Interconnectome: Minimizing Research Waste and Advancing Evidence Synthesis
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Rahgozar, Arya, Mortezaagha, Pouria, Edwards, Jodi, Manuel, Douglas, McGowen, Jessie, Zwarenstein, Merrick, Fergusson, Dean, Tricco, Andrea, Cobey, Kelly, Sampson, Margaret, King, Malcolm, Richards, Dawn, Bodnaruc, Alexandra, and Moher, David
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Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Digital Libraries ,Computer Science - Information Retrieval - Abstract
The Brain-Heart Interconnectome (BHI) combines neurology and cardiology but is hindered by inefficiencies in evidence synthesis, poor adherence to quality standards, and research waste. To address these challenges, we developed an AI-driven system to enhance systematic reviews in the BHI domain. The system integrates automated detection of Population, Intervention, Comparator, Outcome, and Study design (PICOS), semantic search using vector embeddings, graph-based querying, and topic modeling to identify redundancies and underexplored areas. Core components include a Bi-LSTM model achieving 87% accuracy for PICOS compliance, a study design classifier with 95.7% accuracy, and Retrieval-Augmented Generation (RAG) with GPT-3.5, which outperformed GPT-4 for graph-based and topic-driven queries. The system provides real-time updates, reducing research waste through a living database and offering an interactive interface with dashboards and conversational AI. While initially developed for BHI, the system's adaptable architecture enables its application across various biomedical fields, supporting rigorous evidence synthesis, efficient resource allocation, and informed clinical decision-making.
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- 2025
11. Transit-timing variations in the AU Mic system observed with CHEOPS
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Boldog, Á., Szabó, Gy. M., Kriskovics, L., Borsato, L., Gandolfi, D., Lendl, M., Günther, M. N., Heitzmann, A., Wilson, T. G., Brandeker, A., Garai, Z., Alibert, Y., Alonso, R., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Benz, W., Billot, N., Broeg, C., Cameron, A. Collier, Correia, A. C. M., Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. -O., Derekas, A., Edwards, B., Egger, J. A., Ehrenreich, D., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gazeas, K., Gillon, M., Güdel, M., Guterman, P., Helling, Ch., Isaak, K. G., Kiss, L. L., Kopp, E., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Luntzer, A., Magrin, D., Mantovan, G., Marafatto, L., Maxted, P. F. L., Merín, B., Mordasini, C., Munari, M., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Poppenhaeger, K., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Rieder, M., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Sousa, S. G., Southworth, R., Stalport, M., Sulis, S., Udry, S., Ulmer-Moll, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., and Zingales, T.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
AU Mic is a very active M dwarf with an edge-on debris disk and two transiting sub-Neptunes with a possible third planetary companion. The two transiting planets exhibit significant transit-timing variations (TTVs) that are caused by the gravitational interaction between the bodies in the system. Using photometrical observations taken with the CHaracterizing ExOPlanet Satellite (CHEOPS), our goal is to constrain the planetary radii, the orbital distances and periods of AU Mic b and c. We aim to determine the superperiod of the TTVs for AU Mic b and to update the transit ephemeris for both planets. Based on the observed TTVs, we study the possible presence of a third planet in the system. We conducted high precision photometric observations with CHEOPS in 2022 and 2023. We used Allesfitter to fit the planetary transits and to constrain the planetary and orbital parameters. We combined our new measurements with results from previous years to determine the periods and amplitudes of the TTVs. We applied dynamical modelling based on TTV measurements from the 2018-2023 period to reconstruct the perceived variations. The orbital distances and periods for AU Mic b and c agree with the results from previous works. However, the values for the planetary radii deviate slightly from previous values, which we attribute to the effect of stellar spots. AU Mic c showed very strong TTVs, with transits that occurred ~80 minutes later in 2023 than in 2021. Through dynamical analysis of the system, we found that the observed TTVs can be explained by a third planet with an orbital period of ~12.6 days and a mass of 0.203+0.022-0.024 M_E. We explored the orbital geometry of the system and found that AU Mic c has a misaligned retrograde orbit. Due limited number of observations the exact configuration and planetary parameters could not be determined. Further monitoring with CHEOPS may improve these results., Comment: 15 pages, 10 figures
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- 2025
12. Using Statistical Precision Medicine to Identify Optimal Treatments in a Heart Failure Setting
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Virkud, Arti, Edwards, Jessie K., Funk, Michele Jonsson, Chang, Patricia, Kshirsagar, Abhijit V., Gower, Emily W., and Kosorok, Michael R.
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Statistics - Applications - Abstract
Identifying optimal medical treatments to improve survival has long been a critical goal of pharmacoepidemiology. Traditionally, we use an average treatment effect measure to compare outcomes between treatment plans. However, new methods leveraging advantages of machine learning combined with the foundational tenets of causal inference are offering an alternative to the average treatment effect. Here, we use three unique, precision medicine algorithms (random forests, residual weighted learning, efficient augmentation relaxed learning) to identify optimal treatment rules where patients receive the optimal treatment as indicated by their clinical history. First, we present a simple hypothetical example and a real-world application among heart failure patients using Medicare claims data. We next demonstrate how the optimal treatment rule improves the absolute risk in a hypothetical, three-modifier setting. Finally, we identify an optimal treatment rule that optimizes the time to outcome in a real-world heart failure setting. In both examples, we compare the average time to death under the optimized, tailored treatment rule with the average time to death under a universal treatment rule to show the benefit of precision medicine methods. The improvement under the optimal treatment rule in the real-world setting is greatest (additional ~9 days under the tailored rule) for survival time free of heart failure readmission.
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- 2025
13. Introducing new resonant soft x-ray scattering capability in SSRL
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Kuo, Cheng-Tai, Hashimoto, Makoto, Lee, Heemin, Huynh, Tan Thanh, Maciel, Abraham, Zhang, Zina, Zhang, Dehong, Edwards, Benjamin, Kazemifar, Farzan, Kao, Chi-Chang, Lu, Donghui, and Lee, Jun-Sik
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Physics - Instrumentation and Detectors ,Condensed Matter - Materials Science - Abstract
Resonant soft X-ray scattering (RSXS) is a powerful technique for probing both spatial and electronic structures within solid-state systems.We present a newly developed RSXS capability at beamline 13-3 of the Stanford Synchrotron Radiation Lightsource (SSRL), designed to enhance materials science research. This advanced setup achieves a base sample temperature as low as 9.8 K combined with extensive angular motions (azimuthal \phi and flipping \chi), enables comprehensive exploration of reciprocal space. Two types of detectors, an Au/GaAsP Schottky photodiode and a CCD detector with over 95% quantum efficiency, are integrated to effectively capture scattered photons. Extensive testing has confirmed the enhanced functionality of this RSXS setup, including its temperature and angular performance. The versatility and effectiveness of the system have been demonstrated through studies of various materials, including superlattice heterostructures and high-temperature superconductors., Comment: 22 pages, 7 figures
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- 2025
14. Femtosecond temperature measurements of laser-shocked copper deduced from the intensity of the x-ray thermal diffuse scattering
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Wark, J. S., Peake, D. J., Stevens, T., Heighway, P. G., Ping, Y., Sterne, P., Albertazzi, B., Ali, S. J., Antonelli, L., Armstrong, M. R., Baehtz, C., Ball, O. B., Banerjee, S., Belonoshko, A. B., Bolme, C. A., Bouffetier, V., Briggs, R., Buakor, K., Butcher, T., Cafiso, S. Di Dio, Cerantola, V., Chantel, J., Di Cicco, A., Coleman, A. L., Collier, J., Collins, G., Comley, A. J., Coppari, F., Cowan, T. E., Cristoforetti, G., Cynn, H., Descamps, A., Dorchies, F., Duff, M. J., Dwivedi, A., Edwards, C., Eggert, J. H., Errandonea, D., Fiquet, G., Galtier, E., Garcia, A. Laso, Ginestet, H., Gizzi, L., Gleason, A., Goede, S., Gonzalez, J. M., Gorman, M. G., Harmand, M., Hartley, N., Hernandez-Gomez, C., Higginbotham, A., Höppner, H., Humphries, O. S., Husband, R. J., Hutchinson, T. M., Hwang, H., Keen, D. A., Kim, J., Koester, P., Konopkova, Z., Kraus, D., Krygier, A., Labate, L., Lazicki, A. E., Lee, Y., Liermann, H-P., Mason, P., Masruri, M., Massani, B., McBride, E. E., McGuire, C., McHardy, J. D., McGonegle, D., McWilliams, R. S., Merkel, S., Morard, G., Nagler, B., Nakatsutsumi, M., Nguyen-Cong, K., Norton, A-M., Oleynik, I. I., Otzen, C., Ozaki, N., Pandolfi, S., Pelka, A., Pereira, K. A., Phillips, J. P., Prescher, C., Preston, T., Randolph, L., Ranjan, D., Ravasio, A., Redmer, R., Rips, J., Santamaria-Perez, D., Savage, D. J., Schoelmerich, M., Schwinkendorf, J-P., Singh, S., Smith, J., Smith, R. F., Sollier, A., Spear, J., Spindloe, C., Stevenson, M., Strohm, C., Suer, T-A., Tang, M., Toncian, M., Toncian, T., Tracy, S. J., Trapananti, A., Tschentscher, T., Tyldesley, M., Vennari, C. E., Vinci, T., Vogel, S. C., Volz, T. J., Vorberger, J., Willman, J. T., Wollenweber, L., Zastrau, U., Brambrink, E., Appel, K., and McMahon, M. I.
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Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
We present 50-fs, single-shot measurements of the x-ray thermal diffuse scattering (TDS) from copper foils that have been shocked via nanosecond laser-ablation up to pressures above 135~GPa. We hence deduce the x-ray Debye-Waller (DW) factor, providing a temperature measurement. The targets were laser-shocked with the DiPOLE 100-X laser at the High Energy Density (HED) endstation of the European X-ray Free-Electron Laser (EuXFEL). Single x-ray pulses, with a photon energy of 18 keV, were scattered from the samples and recorded on Varex detectors. Despite the targets being highly textured (as evinced by large variations in the elastic scattering), and with such texture changing upon compression, the absolute intensity of the azimuthally averaged inelastic TDS between the Bragg peaks is largely insensitive to these changes, and, allowing for both Compton scattering and the low-level scattering from a sacrificial ablator layer, provides a reliable measurement of $T/\Theta_D^2$, where $\Theta_D$ is the Debye temperature. We compare our results with the predictions of the SESAME 3336 and LEOS 290 equations of state for copper, and find good agreement within experimental errors. We thus demonstrate that single-shot temperature measurements of dynamically compressed materials can be made via thermal diffuse scattering of XFEL radation., Comment: 17 pages, 9 figures in main article; 10 pages, 5 figures in supplementary material
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- 2025
15. White Paper on Software Infrastructure for Advanced Nuclear Physics Computing
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Boehnlein, A., Carlson, J., Cloet, I., Detwiler, J., Diefenthaler, M., Edwards, R., Godbey, K., Hix, R., Jacobs, P. M., Originos, K., Papenbrock, T., Ploskon, M., Ratti, C., Sawatzky, B., Soltz, R., and Wenaus, T.
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Nuclear Theory ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
This White Paper documents the discussion and consensus conclusions of the workshop "Software Infrastructure for Advanced Nuclear Physics Computing" (SANPC 24), which was held at Jefferson Lab on June 20-22, 2024. The workshop brought together members of the US Nuclear Physics community with data scientists and funding agency representatives to discuss the challenges and opportunities in advanced computing for Nuclear Physics in the coming decade. Opportunities for sustainable support and growth are identified within the context of existing and currently planned DOE and NSF programs., Comment: First draft. Open for NP community comment until Feb. 14, 2025. Please submit comments to the corresponding author (pmjacobs@lbl.gov)
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- 2025
16. Class-based Subset Selection for Transfer Learning under Extreme Label Shift
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Goyal, Akul and Edwards, Carl
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Existing work within transfer learning often follows a two-step process -- pre-training over a large-scale source domain and then finetuning over limited samples from the target domain. Yet, despite its popularity, this methodology has been shown to suffer in the presence of distributional shift -- specifically when the output spaces diverge. Previous work has focused on increasing model performance within this setting by identifying and classifying only the shared output classes between distributions. However, these methods are inherently limited as they ignore classes outside the shared class set, disregarding potential information relevant to the model transfer. This paper proposes a new process for few-shot transfer learning that selects and weighs classes from the source domain to optimize the transfer between domains. More concretely, we use Wasserstein distance to choose a set of source classes and their weights that minimize the distance between the source and target domain. To justify our proposed algorithm, we provide a generalization analysis of the performance of the learned classifier over the target domain and show that our method corresponds to a bound minimization algorithm. We empirically demonstrate the effectiveness of our approach (WaSS) by experimenting on several different datasets and presenting superior performance within various label shift settings, including the extreme case where the label spaces are disjoint., Comment: 19 pages
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- 2024
17. On computing local monodromy and the numerical local irreducible decomposition
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Edwards, Parker B. and Hauenstein, Jonathan D.
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Mathematics - Algebraic Geometry ,Mathematics - Numerical Analysis ,65H14, 14Q65, 14Q15, 32S50 - Abstract
Similarly to the global case, the local structure of a holomorphic subvariety at a given point is described by its local irreducible decomposition. Following the paradigm of numerical algebraic geometry, an algebraic subvariety at a point is represented by a numerical local irreducible decomposition comprised of a local witness set for each local irreducible component. The key requirement for obtaining a numerical local irreducible decomposition is to compute the local monodromy action of a generic linear projection at the given point, which is always well-defined on any small enough neighborhood. We characterize some of the behavior of local monodromy action of linear projection maps under analytic continuation, allowing computations to be performed beyond a local neighborhood. With this characterization, we present an algorithm to compute the local monodromy action and corresponding numerical local irreducible decomposition for algebraic varieties. The results are illustrated using several examples facilitated by an implementation in an open source software package., Comment: 20 pages, 7 figures
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- 2024
18. The impact of motor and non-motor symptoms fluctuations on health-related quality of life in people with functional motor disorder
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Jirásek, Martin, Sieger, Tomáš, Chaloupková, Gabriela, Nováková, Lucia, Sojka, Petr, Edwards, Mark J, and Serranová, Tereza
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Quantitative Biology - Neurons and Cognition - Abstract
Objective: To assess the effect of overall, between- and within-day subjectively rated fluctuations in motor and non-motor symptoms in people with functional motor disorder (FMD) on the health-related quality of life (HRQoL). Background: FMD is a complex condition characterized by fluctuating motor and non-motor symptoms that may negatively impact HRQoL. Methods: Seventy-seven patients (54 females, mean age 45.4 (SD 10.4) years) with a clinically established diagnosis of FMD, including weakness, completed symptom diaries, rating the severity of motor and non-motor symptoms (i.e., pain, fatigue, mood, cognitive difficulties) on a 10-point numerical scale three times daily for seven consecutive days. HRQoL was assessed using the SF-36 questionnaire. For the analysis, fluctuation magnitude was defined in terms of the variability in self-reported symptom scores. Results: The mental component of SF-36 was jointly predicted by the overall severity scores (P<0.001) and overall general fluctuations (P=0.004). The physical SF-36 was found to be related only to the overall symptom severity scores (P<0.001), but not to the overall fluctuations. The assessment of the impact of different components showed that the mental component of SF-36 was significantly influenced by the combined effect of average fatigue (P<0.001), between-day cognitive symptoms fluctuations (P=0.002), and within-day mood fluctuations (P=0.015). Conclusions: This study demonstrated the impact of self-reported symptom fluctuations across multiple motor and non-motor domains on mental but not physical HRQoL in FMD and highlighted the importance of assessing and managing fluctuations in clinical practice., Comment: 21 pages, 3 figures
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- 2024
19. Enabling the Verification and Formalization of Hybrid Quantum-Classical Computing with OpenQASM 3.0 compatible QASM-TS 2.0
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Kim, Sean and Edwards, Marcus
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Computer Science - Programming Languages ,Quantum Physics - Abstract
The unique features of the hybrid quantum-classical computing model implied by the specification of OpenQASM 3.0 motivate new approaches to quantum program verification. We implement a typed QASM 3.0 parser in TypeScript to enable implementations of verification and validation software, compilers and more. We also propose that a formal treatment of OpenQASM 3.0's type system in type theory notation may further facilitate formal verification. We highlight advancements in hybrid quantum-classical computing since the Quantum Hoare Logic to this end.
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- 2024
20. Transformers Use Causal World Models in Maze-Solving Tasks
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Spies, Alex F., Edwards, William, Ivanitskiy, Michael I., Skapars, Adrians, Räuker, Tilman, Inoue, Katsumi, Russo, Alessandra, and Shanahan, Murray
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,I.2 - Abstract
Recent studies in interpretability have explored the inner workings of transformer models trained on tasks across various domains, often discovering that these networks naturally develop surprisingly structured representations. When such representations comprehensively reflect the task domain's structure, they are commonly referred to as ``World Models'' (WMs). In this work, we discover such WMs in transformers trained on maze tasks. In particular, by employing Sparse Autoencoders (SAEs) and analysing attention patterns, we examine the construction of WMs and demonstrate consistency between the circuit analysis and the SAE feature-based analysis. We intervene upon the isolated features to confirm their causal role and, in doing so, find asymmetries between certain types of interventions. Surprisingly, we find that models are able to reason with respect to a greater number of active features than they see during training, even if attempting to specify these in the input token sequence would lead the model to fail. Futhermore, we observe that varying positional encodings can alter how WMs are encoded in a model's residual stream. By analyzing the causal role of these WMs in a toy domain we hope to make progress toward an understanding of emergent structure in the representations acquired by Transformers, leading to the development of more interpretable and controllable AI systems., Comment: Main paper: 9 pages, 9 figures. Supplementary material: 10 pages, 17 additional figures. Code and data will be available upon publication. Corresponding author: A. F. Spies (afspies@imperial.ac.uk)
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- 2024
21. Combined analysis of the 12.8 and 15 $\mu m$ JWST/MIRI eclipse observations of TRAPPIST-1 b
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Ducrot, Elsa, Lagage, Pierre-Olivier, Min, Michiel, Gillon, Michael, Bell, Taylor J., Tremblin, Pascal, Greene, Thomas, Dyrek, Achrene, Bouwman, Jeroen, Waters, Rens, Gudel, Manuel, Henning, Thomas, Vandenbussche, Bart, Absil, Olivier, Barrado, David, Boccaletti, Anthony, Coulais, Alain, Decin, Leen, Edwards, Billy, Gastaud, Rene, Glasse, Alistair, Kendrew, Sarah, Olofsson, Goran, Patapis, Polychronis, Pye, John, Rouan, Daniel, Whiteford, Niall, Argyriou, Ioannis, Cossou, Christophe, Glauser, Adrian M., Krause, Oliver, Lahuis, Fred, Royer, Pierre, Scheithauer, Silvia, Colina, Luis, van Dishoeck, Ewine F., Ostlin, Goran, Ray, Tom P., and Wright, Gillian
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The first JWST/MIRI photometric observations of TRAPPIST-1 b allowed for the detection of the thermal emission of the planet at 15 $\mu m$, suggesting that the planet could be a bare rock with a zero albedo and no redistribution of heat. These observations at 15 $\mu m$ were acquired as part of GTO time that included a twin program at 12.8 $\mu m$ in order to have a measurement in and outside the CO$_2$ absorption band. Here we present five new occultations of TRAPPIST-1 b observed with MIRI in an additional photometric band at 12.8 $\mu m$. We perform a global fit of the 10 eclipses and derive a planet-to-star flux ratio and 1-$\sigma$ error of 452 $\pm$ 86 ppm and 775 $\pm$ 90 ppm at 12.8 $\mu m$ and 15 $\mu m$, respectively. We find that two main scenarios emerge. An airless planet model with an unweathered (fresh) ultramafic surface, that could be indicative of relatively recent geological processes fits well the data. Alternatively, a thick, pure-CO2 atmosphere with photochemical hazes that create a temperature inversion and result in the CO2 feature being seen in emission also works, although with some caveats. Our results highlight the challenges in accurately determining a planet's atmospheric or surface nature solely from broadband filter measurements of its emission, but also point towards two very interesting scenarios that will be further investigated with the forthcoming phase curve of TRAPPIST-1 b., Comment: 49 pages, 3 main text figure, 2 extended figures, 10 supplementary figures, accepted for publication in Nature Astronomy on October 29, 2024
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- 2024
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22. The role of Enhanced Geothermal Systems in the energy transition at Cornell -- Report of a workshop held at Cornell University, Ithaca, October 23-24, 2024
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Arson, Chloé, Balog-Way, Dominic, Beckers, Koenraad, Bezner-Kerr, Wayne, Carson, Sarah, Edwards, Stacey, Fulton, Patrick, Gillenwater, Michael, Goetze, Trystan, Gustafson, Olaf, Ingraffea, Tony, Jordan, Terry, McComas, Katherine, Olmstead, Sheila, Saltiel, Seth, Tester, Jeff, Tucker, Cole, and Wells, Marguerite
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Physics - Geophysics - Abstract
To review the lessons learnt from recent deep geothermal case studies and plan strategically the research, development, regulation, and communication work required for the implementation of an Enhanced Geothermal System (EGS) at Cornell University, a group of engineers and scholars convened a two-day workshop on the Ithaca campus, on October 23-24, 2024. The event was funded by Cornell Atkinson Center for Sustainability. This report is a summary of the content of the presentations and discussions that took place during the workshop. The first section focuses on philosophical, sociological, economic, and regulatory questions posed by EGS deployment as a means to mitigate climate change. The second section tackles the scientific and technological research areas associated with EGS. The third section aims to assess the feasibility of developing EGS for heat direct use at Cornell University, based on results and information available to date. The report concludes with a summary of the most salient technological and scientific breakthroughs, and a plan for future technological and academic engagement in EGS projects at Cornell.
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- 2024
23. CHEOPS observations confirm nodal precession in the WASP-33 system
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Smith, A. M. S., Csizmadia, Sz., Van Grootel, V., Lendl, M., Persson, C. M., Olofsson, G., Ehrenreich, D., Günther, M. N., Heitzmann, A., Barros, S. C. C., Bonfanti, A., Brandeker, A., Cabrera, J., Demangeon, O. D. S., Fossati, L., Harre, J. -V., Hooton, M. J., Hoyer, S., Kalman, Sz., Salmon, S., Sousa, S. G., Szabó, Gy. M., Wilson, T. G., Alibert, Y., Alonso, R., Asquier, J., Bárczy, T., Barrado, D., Baumjohann, W., Benz, W., Billot, N., Borsato, L., Broeg, C., Cameron, A. Collier, Correia, A. C. M., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demory, B. -O., Derekas, A., Edwards, B., Egger, J. A., Erikson, A., Fortier, A., Fridlund, M., Gandolfi, D., Gazeas, K., Gillon, M., Güdel, M., Hasiba, J., Helling, Ch., Isaak, K. G., Kiss, L. L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Magrin, D., Maxted, P. F. L., Merín, B., Mordasini, C., Nascimbeni, V., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Stalport, M., Sulis, S., Udry, S., Ulmer-Moll, S., Venturini, J., Villaver, E., Viotto, V., Walter, I., Walton, N. A., and Wolf, S.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims: We aim to observe the transits and occultations of WASP-33b, which orbits a rapidly-rotating $\delta$ Scuti pulsator, with the goal of measuring the orbital obliquity via the gravity-darkening effect, and constraining the geometric albedo via the occultation depth. Methods: We observed four transits and four occultations with CHEOPS, and employ a variety of techniques to remove the effects of the stellar pulsations from the light curves, as well as the usual CHEOPS systematic effects. We also performed a comprehensive analysis of low-resolution spectral and Gaia data to re-determine the stellar properties of WASP-33. Results: We measure an orbital obliquity 111.3 +0.2 -0.7 degrees, which is consistent with previous measurements made via Doppler tomography. We also measure the planetary impact parameter, and confirm that this parameter is undergoing rapid secular evolution as a result of nodal precession of the planetary orbit. This precession allows us to determine the second-order fluid Love number of the star, which we find agrees well with the predictions of theoretical stellar models. We are unable to robustly measure a unique value of the occultation depth, and emphasise the need for long-baseline observations to better measure the pulsation periods., Comment: 18 pages, 12 figures. Accepted for publication in Astronomy & Astrophysics
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- 2024
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24. Characterization of seven transiting systems including four warm Jupiters from SOPHIE and TESS
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Heidari, N., H'ebrard, G., Martioli, E., Eastman, J. D., Jackson, J. M., Delfosse, X., Jord'an, A., Correia, A. C. M., Sousa, S., Dragomir, D., Forveille, T., Boisse, I., Giacalone, S. A., D'iaz, R. F., Brahm, R., Almasian, D., Almenara, J. M., Bieryla, A., Barkaoui, K., Baker, D., Barros, S. C. C ., Bonfils, X., Carmona, A., Collins, K. A., Cort'es-Zuleta, P., Deleuil, M., Demangeon, O. D. S., Edwards, B., Eberhardt, J., Espinoza, N., Eisner, N., Feliz, D. L., Frommer, A. C., Fukui, A., Grau, F., Gupta, A. F., Hara, N., Hobson, M. J., Henning, T., Howell, S. B., Jenkins, J. M., Kiefer, F., LaCourse, D. M., Laskar, J., Law, N., Mann, A. W., Murgas, F., Moutou, C., Narita, N., Palle, E., Relles, H. M., Stassun, K. G., Bell, J. Serrano, Schwarz, R. P., Srdoc, G., Strøm, P. A., Safonov, B., Sarkis, P., Schlecker, M., Pinto, M. Tala, Pepper, J., Rojas, F. I., Twicken, J. D., Trifonov, T., Villanueva Jr, S., Watkins, C. N., Winn, J. N., and Ziegler, C.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the study of seven systems, three of which TOI-2295, TOI-2537, and TOI-5110 are newly discovered planetary systems. Through the analysis of TESS photometry, SOPHIE radial velocities, and high-spatial resolution imaging, we found that TOI-2295b, TOI-2537b, and TOI-5110b are transiting warm Jupiters with orbital periods ranging from 30 to 94 d, masses between 0.9 and 2.9 MJ, and radii ranging from 1.0 to 1.5 RJ. Both TOI-2295 and TOI-2537 each harbor at least one additional, outer planet. Their outer planets TOI-2295c and TOI-2537c are characterized by orbital periods of 966.5 +/- 4.3 and 1920^{+230}_{-140} d, respectively, and minimum masses of 5.61^{+0.23}_{-0.24} and 7.2 +/- 0.5 MJ, respectively. We also investigated and characterized the two recently reported warm Jupiters TOI-1836b and TOI-5076b, which we independently detected in SOPHIE RVs. Additionally, we study the planetary candidates TOI-4081.01 and TOI-4168.01. For TOI-4081.01, despite our detection in radial velocities, we cannot rule out perturbation by a blended eclipsing binary and thus exercise caution regarding its planetary nature. On the other hand, we identify TOI-4168.01 as a firm false positive. Finally, we highlight interesting characteristics of these new planetary systems. The transits of TOI-2295b are highly grazing, with an impact parameter of 1.056$^{+0.063}_{-0.043}$. TOI-2537b, in turn, is a temperate Jupiter with an effective temperature of 307+/-15 K and can serve as a valuable low-irradiation control for models of hot Jupiter inflation anomalies. We also detected significant transit timing variations (TTVs) for TOI-2537b, which are likely caused by gravitational interactions with the outer planet TOI-2537c. Finally, TOI-5110b stands out due to its orbital eccentricity of 0.75+/- 0.03, one of the highest planetary eccentricities discovered thus far., Comment: 46 pages, 21 figures, accepted for publication in A&A
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- 2024
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25. Reputation Management in the ChatGPT Era
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Edwards, Lilian and Binns, Reuben
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Computer Science - Computers and Society - Abstract
Generative AI systems often generate outputs about real people, even when not explicitly prompted to do so. This can lead to significant reputational and privacy harms, especially when sensitive, misleading, and outright false. This paper considers what legal tools currently exist to protect such individuals, with a particular focus on defamation and data protection law. We explore the potential of libel law, arguing that it is a potential but not an ideal remedy, due to lack of harmonization, and the focus on damages rather than systematic prevention of future libel. We then turn to data protection law, arguing that the data subject rights to erasure and rectification may offer some more meaningful protection, although the technical feasibility of compliance is a matter of ongoing research. We conclude by noting the limitations of these individualistic remedies and hint at the need for a more systemic, environmental approach to protecting the infosphere against generative AI., Comment: ACM Symposium on Computer Science and Law 2025
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- 2024
26. Schema Evolution in Interactive Programming Systems
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Edwards, Jonathan, Petricek, Tomas, van der Storm, Tijs, and Litt, Geoffrey
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Computer Science - Programming Languages - Abstract
Many improvements to programming have come from shortening feedback loops, for example with Integrated Development Environments, Unit Testing, Live Programming, and Distributed Version Control. A barrier to feedback that deserves greater attention is Schema Evolution. When requirements on the shape of data change then existing data must be migrated into the new shape, and existing code must be modified to suit. Currently these adaptations are often performed manually, or with ad hoc scripts. Manual schema evolution not only delays feedback but since it occurs outside the purview of version control tools it also interrupts collaboration. Schema evolution has long been studied in databases. We observe that the problem also occurs in non-database contexts that have been less studied. We present a suite of challenge problems exemplifying this range of contexts, including traditional database programming as well as live front-end programming, model-driven development, and collaboration in computational documents. We systematize these various contexts by defining a set of layers and dimensions of schema evolution. We offer these challenge problems to ground future research on the general problem of schema evolution in interactive programming systems and to serve as a basis for evaluating the results of that research. We hope that better support for schema evolution will make programming more live and collaboration more fluid., Comment: arXiv admin note: text overlap with arXiv:2309.11406
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- 2024
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27. The Spectral Behaviour and Variability of Narrow-line Seyfert 1 Galaxies with Australia Telescope Compact Array Observations
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Shao, Xi, Edwards, Philip G., Stevens, Jamie, Gu, Minfeng, Galvin, Timothy J., and Huynh, Minh T.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present multi-frequency radio data for a sample of narrow-line Seyfert 1 galaxies. We first focus on the sub-class of gamma-ray emitting narrow-line Seyfert 1 galaxies, studying the long-term radio variability of five sources and comparing it to their gamma-ray state. We then extend the observations of the southern narrow-line Seyfert 1 galaxy sample of Chen et al. by observing several candidate narrow-line Seyfert 1 sources for the first time, and re-observing several other gamma-ray quiet sources to obtain a first indication of their radio variability. We find that the gamma-ray emitting narrow-line Seyfert 1 galaxies are highly variable radio emitters and that there are instances of contemporaneous flaring activity between the radio and gamma-ray band (PKS 0440$-$00, PMN J0948+0022 and PKS 1244$-$255). However, there are also cases of significant radio outbursts without gamma-ray counterparts (PMN J0948+0022 and PKS 2004$-$447). The five gamma-ray NLS1s favour flat or inverted radio spectra, although the spectral indices vary significantly over time. For the gamma-ray quiet sample, the difference between the previous observations at 5.5 GHz and new ATCA observations indicates that over half of the 14 sources exhibit apparent variability. In contrast to gamma-ray loud sources, gamma-ray quiet objects tend to have steep spectra especially in the lower radio band (887.5$-$1367.5 MHz), with a number of the variable sources having flatter spectra at higher radio frequencies., Comment: Accepted for publication in MNRAS (13 pages, 7 figures)
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- 2024
28. Robust implicit quantum control of interacting spin chains
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Stefanescu, Luca, Edwards-Pratt, Louis, O'Connor, Jeremy, Tsegaye, Ezra, Le, Nguyen H., and Mintert, Florian
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Quantum Physics - Abstract
Robust quantum control can achieve noise-resilience of quantum systems and quantum technological devices. While the need for noise-resilience grows with the number of fluctuating quantities, and thus typically with the number of qubits, most numerically exact optimal control techniques are limited to systems of few interacting qubits. This paper exploits quantum control that avoids explicit reference to quantum states in exponentially large Hilbert space. Exemplary control protocols for spin chains are discussed in terms of noise-resilient preparation of highly entangled states., Comment: 12 pages, 9 figures
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- 2024
29. A joint effort to discover and characterize two resonant mini Neptunes around TOI-1803 with TESS, HARPS-N and CHEOPS
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Zingales, T., Malavolta, L., Borsato, L., Turrini, D., Bonfanti, A., Polychroni, D., Mantovan, G., Nardiello, D., Nascimbeni, V., Lanza, A. F., Bekkelien, A., Sozzetti, A., Broeg, C., Naponiello, L., Lendl, M., Bonomo, A. S., Simon, A. E., Desidera, S., Piotto, G., Mancini, L., Hooton, M. J., Bignamini, A., Egger, J. A., Maggio, A., Alibert, Y., Locci, D., Delrez, L., Biassoni, F., Fossati, L., Cabona, L., Lacedelli, G., Carleo, I., Leonardi, P., Andreuzzi, G., Brandeker, A., Cosentino, R., Correia, A. C. M., Claudi, R., Alonso, R., Damasso, M., Wilson, T. G., Bàrczy, T., Pinamonti, M., Baker, D., Barkaoui, K., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, T., Beichman, C., Benz, W., Bieryla, A., Billot, N., Bosch-Cabot, P., Bouma, L. G., Ciardi, D. R., Cameron, A. Collier, Collins, K. A., Crossfield, Ian J. M., Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Deleuil, M., Deline, A., Demangeon, O. D. S., Demory, B. O., Derekas, A., Dragomir, D., Edwards, B., Ehrenreich, D., Erikson, A., Falk, B., Fortier, A., Fridlund, M., Fukui, A., Gandolfi, D., Gazeas, K., Gillon, M., Gonzales, E., Gudel, M., Guerra, P., Guunther, M. N., Heitzmann, A., Helling, Ch., Howell, S. B., Isaak, K. G., Jenkins, J., Kiss, L. L., Korth, J., Lam, K. W. F., Laskar, J., Etangs, A. Lecavelier des, Magrin, D., Matson, R., Matthews, E. C., Maxted, P. F. L., McDermott, S., Munari, M., Mordasini, C., Narita, N., Olofsson, G., Ottensamer, R., Pagano, I., Pallè, E., Peter, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Salmon, S., Santos, N. C., Scandariato, G., Seager, S., Sègransan, D., Smith, A. M. S., Schlieder, J., Schwarz, R. P., Shporer, A., Sousa, S. G., Stalport, M., Steinberger, M., Sulis, S., Szabò, Gy. M., Twicken, J. D., Udry, S., Van Grootel, V., Venturini, J., Villaver, E., Walton, N. A., and Winn, J. N.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the discovery of two mini Neptunes near a 2:1 orbital resonance configuration orbiting the K0 star TOI-1803. We describe their orbital architecture in detail and suggest some possible formation and evolution scenarios. Using CHEOPS, TESS, and HARPS-N datasets we can estimate the radius and the mass of both planets. We used a multidimensional Gaussian Process with a quasi-periodic kernel to disentangle the planetary components from the stellar activity in the HARPS-N dataset. We performed dynamical modeling to explain the orbital configuration and performed planetary formation and evolution simulations. For the least dense planet, we define possible atmospheric characterization scenarios with simulated JWST observations. TOI-1803 b and TOI-1803 c have orbital periods of $\sim$6.3 and $\sim$12.9 days, respectively, residing in close proximity to a 2:1 orbital resonance. Ground-based photometric follow-up observations revealed significant transit timing variations (TTV) with an amplitude of $\sim$10 min and $\sim$40 min, respectively, for planet -b and -c. With the masses computed from the radial velocities data set, we obtained a density of (0.39$\pm$0.10) $\rho_{earth}$ and (0.076$\pm$0.038) $\rho_{earth}$ for planet -b and -c, respectively. TOI-1803 c is among the least dense mini Neptunes currently known, and due to its inflated atmosphere, it is a suitable target for transmission spectroscopy with JWST. We report the discovery of two mini Neptunes close to a 2:1 orbital resonance. The detection of significant TTVs from ground-based photometry opens scenarios for a more precise mass determination. TOI-1803 c is one of the least dense mini Neptune known so far, and it is of great interest among the scientific community since it could constrain our formation scenarios., Comment: 26 Pages, 21 Figures Accepted for Publication in Astronomy & Astrophysics
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- 2024
30. A Global Perspective with Updated Constraints on the Ultra-hot Jupiter WASP-19b: Atmospheric Properties and Stellar Activity
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Tumborang, Abigail A., Spake, Jessica J., Knutson, Heather A., Mansfield, Megan Weiner, Paragas, Kimberly, Edwards, Billy, Kataria, Tiffany, Evans-Soma, Thomas M., Lewis, Nikole K., and Ballester, Gilda E.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present a detailed reanalysis of the atmospheric properties of WASP-19b, an ultra-hot Jupiter (1.14 M Jup, 1.41 R Jup) orbiting an active Sun-like star every 0.79 day. We reanalyze a transit and secondary eclipse of WASP-19b observed by the Hubble Space Telescope's Wide Field Camera 3 spectrograph (1.1 - 1.7 microns). When combined with Spitzer photometry at longer wavelengths, our analyses indicate the presence of water absorption features in both the planet's transmission and emission spectra, consistent with results from previously published studies. We jointly fit WASP-19b's dayside emission and transmission spectra with a retrieval model in order to constrain its atmospheric composition, and explore the effect of stellar activity on its transmission spectrum in greater depth. We also compare our dayside emission spectrum to predictions from a general circulation model, and conclude that magnetic drag appears to be relatively unimportant in shaping WASP-19b's atmospheric circulation. Lastly, we compare the size of WASP-19b's dayside water absorption feature to the population of hot Jupiters with similar measurements, and show that it is located in the transitional irradiation regime where temperature inversions first begin to emerge. As in previous studies, we find that the current observations provide relatively weak constraints on this planet's atmospheric properties. These constraints could be significantly improved by the addition of spectroscopically resolved observations at longer wavelengths with JWST/NIRSpec PRISM.
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- 2024
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31. First Detection of Radio Emission from the Intermediate Mass Black Hole in POX 52: Deep Multi-Band Observations with ATCA and VLA
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Yuan, Qi, Guo, Hengxiao, Gu, Minfeng, Stevens, Jamie, Edwards, Philip G., Chen, Yongjun, Zuo, Wenwen, Sun, Jingbo, Yang, Jun, Lira, Paulina, An, Tao, Su, Renzhi, Liu, Yuanqi, Wang, Yijun, Chang, Ning, Jiang, Pengfei, and Zhang, Ming
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the first multi-band centimeter detection of POX 52, a nearby dwarf galaxy believed to habor a robust intermediate mass black hole (IMBH). We conducted the deep observations using the Australia Telescope Compact Array (ATCA), spanning frequencies from 4.5 to 10 GHz, as well as the sensitive observations from the Karl G. Jansky Very Large Array (VLA) operating in its most extended A-configuration at S band (2--4 GHz) and C band (4--8 GHz). In the ATCA observations, the source shows a compact morphology, with only one direction marginally resolved. The higher resolution of the VLA allowed us to slightly resolve the source, fitting it well with a two-dimensional Gaussian model. The detected radio emission confirms the presence of Active Galactic Nucleus (AGN) activity, indicating either a low-power jet or AGN-driven winds/outflows. Our dual-epoch observations with ATCA and VLA, together with previous non-detection flux density upper limits, reveal radio emission variability spanning two decades. In addition, we find that POX 52 aligns well with the low-mass extension of the fundamental plane for high-accretion, radio-quiet massive AGNs., Comment: 11 pages, 3 figures, 1 table. Accepted for publication in ApJ
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- 2024
32. High-energy transient gas pinholes via saturated absorption
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Ou, Ke, Perez-Ramirez, Victor M., Cao, Sida, Redshaw, Caleb, Lee, Jin, Wang, Michelle M., Mikhailova, Julia M., Michel, Pierre, and Edwards, Matthew R.
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Physics - Optics - Abstract
This letter presents a spatial filter based on saturated absorption in gas as a replacement for the solid pinhole in a lens-pinhole-lens filtering system. We show that an ultraviolet laser pulse focused through ozone will have its spatial profile cleaned if its peak fluence rises above the ozone saturation fluence. Specifically, we demonstrate that a 5 ns 266 nm beam with 4.2 mJ of initial energy can be effectively cleaned by focusing through a 1.4% ozone-oxygen mixture, with about 76% of the main beam energy transmitted and 89% of the side lobe energy absorbed. This process can be adapted to other gases and laser wavelengths, providing alignment-insensitive and damage-resistant pinholes for high-repetition-rate high-energy lasers.
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- 2024
33. Advancing Tritium Self-Sufficiency in Fusion Power Plants: Insights from the BABY Experiment
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Delaporte-Mathurin, Remi, Goles, Nikola, Ball, John, Dunn, Collin, Edwards, Emily, Ferry, Sara, Lamere, Edward, Lanzrath, Andrew, Leccacorvi, Rick, Meschini, Samuele, Peterson, Ethan, Segantin, Stefano, Vieira, Rui, Whyte, Dennis, Zhou, Weiyue, and Woller, Kevin
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Physics - Plasma Physics ,Nuclear Experiment - Abstract
In the pursuit of fusion power, achieving tritium self-sufficiency stands as a pivotal challenge. Tritium breeding within molten salts is a critical aspect of next-generation fusion reactors, yet experimental measurements of \gls{tbr} have remained elusive. Here we present the results of the \gls{baby} experiment, which represents a pioneering effort in tritium research by utilizing high-energy (\SI{14}{\mega\electronvolt}) neutron irradiation of molten salts, a departure from conventional low-energy neutron approaches. Using a small-scale (\SI{100}{\milli\litre}) molten salt tritium breeding setup, we not only simulated, but also directly measured a \gls{tbr}. This innovative approach provides crucial experimental validation, offering insights unattainable through simulation alone. Moreover, our findings reveal a surprising outcome: tritium was predominantly collected as HT, contrary to the expected TF. This underscores the complexity of tritium behavior in molten salts, highlighting the need for further investigation. This work lays the foundation for a more sophisticated experimental setup, including increasing the volume of the breeder, enhancing neutron detection, and refining tritium collection systems. Such improvements are crucial for advancing our understanding of fusion reactor feasibility and paving the way for future experiments.
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- 2024
34. Accessibility In Research Administration
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Catherine Malcolm Edwards, Jessie Gunnell, Vicente Del Solar, David Phipps, and Jeffrey Edwards
- Abstract
This collaborative and reflective inquiry-based paper critically examines accessibility within the research realm. We focus this inquiry on the principles of equity, diversity and inclusion and specifically address the challenges of establishing accessibility as part of the research enterprise. We acknowledge and reflect on the pivotal role accessibility for persons with disabilities play in an equitable research enterprise and reflect on how nuances in language, behavior, and power dynamics all play a role in creating inclusive environments. This reflective inquiry is a result of a facilitated workshop that took place at a conference attended by professionals working within research administration. Using an inquiry-based workshop approach, facilitators worked with workshop colleagues to discuss, regardless of job title, an ability to influence and shape a more inclusive and accessible system at all levels. Our desired outcomes of this workshop were to collate the collective experiences of our colleagues to uncover barriers and facilitators related to accessibility and to support and learn from our colleagues around ways to create an accessible environment that is a norm. What we find is that accessibility impacts everyone in some way, but it is not a one-size-fits-all solution. Collaboration and communication strategies present possible support pathways to more accessible environments.
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- 2024
35. College Students' Perceptions of Alcohol's Role in Disclosures of Sexual Assault and Intimate Partner Violence
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Emily A. Waterman, Lindsey M. Rodriguez, Sarah E. Ullman, Emily R. Dworkin, Katie M. Edwards, and Christina M. Dardis
- Abstract
Objective: Much is known about how alcohol increases the risk of sexual assault or intimate partner violence victimization during college. This research qualitatively explores perceptions about how alcohol influences "disclosures about these events" to informal supports. Participants: Participants included college students who received a disclosure wherein they or the survivor were drinking during the disclosure (n = 81). Methods: Responses were coded with regard to who was drinking and whether the effect of drinking during the disclosure was perceived as positive, negative, mixed, or neutral/none. Results: Participants perceived alcohol to have both positive (e.g., increasing the likelihood of discussing difficult topics) and negative (e.g., cognitive impairment increased negative emotions) effects on disclosures. Conclusion: Prevention and intervention efforts should identify targeted strategies (e.g., remembering one or two easy and helpful phrases; revisiting the topic again while sober) to help survivors and disclosure recipients have constructive conversations in the presence of alcohol.
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- 2025
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36. Post-Colonial Contexts, the State, and Education Reform: A Framework for Understanding the Ethos of Privatization
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D. Brent Edwards, Mauro C. Moschetti, and Alejandro Caravaca
- Abstract
The central argument of this article is that post-colonial states operate--and have always operated, due to their roots in colonialism and capitalism--according to an "ethos of privatization," through which state agents derive private benefit from positions ostensibly responsible for providing public services. The article offers a framework for understanding the ethos of privatization as central to state behavior that is based on insights from literatures in four areas: global education policy, political economy, world systems theory, and post-colonial studies. The article demonstrates the theoretical and methodological value of this framework for producing critical public policy knowledge by applying it to the case of educational privatization in Honduras. The article concludes with a discussion of the benefits of this framework, particularly vis-à-vis more established approaches rooted in the policy sociology literature.
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- 2025
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37. Bursty, Irregular Speech Input to Children Predicts Vocabulary Size
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Margaret Cychosz, Rachel R. Romeo, Jan R. Edwards, and Rochelle S. Newman
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Children learn language by listening to speech from caregivers around them. However, the type and quantity of speech input that children are exposed to change throughout early childhood in ways that are poorly understood due to the small samples (few participants, limited hours of observation) typically available in developmental psychology. Here we used child-centered audio recorders to unobtrusively measure speech input in the home to 292 children (aged 2-7 years), acquiring English in the United States, over 555 distinct days (approximately 8600 total hours of observation, or 29.62 h/child). These large timescales allowed us to compare how different dimensions of child-directed speech input (quantity, burstiness) varied throughout early childhood. We then evaluated the relationship between each dimension of input and children's concurrent receptive vocabulary size. We found that the burstiness of speech input (spikes of words) was a stronger correlate with age than the quantity of speech input. Input burstiness was also a stronger predictor than input quantity for children's vocabulary size: children who heard spiky, more intense bouts of input had larger vocabularies. Overall, these results reaffirm the importance of speech input in the home for children's language development and support exposure--consolidation models of early language development.
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- 2025
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38. Barriers to Racial Equity for Teachers of Color and Indigenous Teachers in California's Teaching Pipeline and Profession. A Civil Rights Agenda for California's Next Quarter Century
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University of California, Los Angeles. Civil Rights Project / Proyecto Derechos Civiles, Kai Mathews, Hui Huang, Erika Yagi, Cathy Balfe, Christopher Mauerman, and Earl J. Edwards
- Abstract
The diversity of California's teaching force continues to lag behind its student population. While students of Color make up 78% of the state's K-12 population, Teachers of Color and Indigenous Teachers (TOCIT) comprise just 34% of the teaching workforce (California Department of Education, 2018), a statistic that has dominated the teacher shortage narrative. Although there is promise in the fact that teacher education program (TEP) enrollment is more diverse than the state's current educator workforce, it's still 27% less diverse than the state's K-12 students. As demand for greater representation increases, so have the initiatives to recruit and retain more racially diverse teachers. In the past few years, California has spent billions in an effort to diversify its teacher workforce, including Assembly Bill 520, which allocated $15 million to be distributed to school districts to develop and implement programs that diversify teaching staffs, and Assembly Bill 130, which appropriated $350 million over the next five years to create or expand Teacher Residency Programs, a pathway that has been shown to recruit and retain higher numbers of TOCIT (California Legislative Information, 2023). This study sets out to (1) explore how current policies, structures, practices, attitudes, and ideologies across the pipeline and profession impede the recruitment and retention of TOCIT, and (2) better understand the racialized experiences and perspectives of pre-service and in-service Teachers of Color and Indigenous Teachers. The following paper is based on a mix of qualitative and quantitative data collected from system leaders in teacher preparation, pre-service teachers, in-service teachers, and former teachers over the course of approximately one year: spring 2021 to summer 2022.
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- 2024
39. Review of Policy Effects on Black Families and Children: Advancing the Black Child National Agenda
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University of North Carolina at Chapel Hill, FPG Child Development Institute, Evandra Catherine, Brittany Alexander, Iheoma U. Iruka, Shantel Meek, and Mary C. Edwards
- Abstract
In September 2021, the Equity Research Action Coalition, in partnership with the National Black Child Development Institute and POINTS of ACCESS, LLC, collaborated in creating the Black Child National Agenda to challenge the negative and stereotypical narrative of Black children, families, and communities and to identify 10 priorities to dismantle structural racism and systemic inequities that get in the way of Black children's ability to thrive and excel. This report advances the Black Child National Agenda by examining major policies and programs in the United States that impact the lives of Black children and families based on the access, experiences, and outcomes framework. [This report was produced with Children's Equity Project.]
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- 2024
40. A Protocol to Assess Contextual Factors during Program Impact Evaluation: A Case Study of a STEM Gender Equity Intervention in Higher Education
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Suzanne Nobrega, Kasper Edwards, Mazen El Ghaziri, Lauren Giacobbe, Serena Rice, and Laura Punnett
- Abstract
Program evaluations that lack experimental design often fail to produce evidence of impact because there is no available control group. Theory-based evaluations can generate evidence of a program's causal effects if evaluators collect evidence along the theorized causal chain and identify possible competing causes. However, few methods are available for assessing competing causes in the program environment. Effect Modifier Assessment (EMA) is a method previously used in smaller-scale studies to assess possible competing causes of observed changes following an intervention. In our case study of a university gender equity intervention, EMA generated useful evidence of competing causes to augment program evaluation. Top-down administrative culture, poor experiences with hiring and promotion, and workload were identified as impeding forces that might have reduced program benefits. The EMA addresses a methodological gap in theory-based evaluation and might be useful in a variety of program settings.
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- 2024
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41. Training the Trainers: The Work of Student Affairs Professionals in Leadership Training
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Sarah R. Edwards and Joshua K. Taylor
- Abstract
Although universities often expect student affairs staff to possess advanced leadership skills, many have not undergone formal training as leadership educators, which often leads to inconsistent outcomes in leadership development programs. Drawing on best practices in facilitating leadership learning --including the use of multiple pedagogies, critical reflection, and the avoidance of superficial or unstructured facilitation--we argue leadership educators require specialized training to effectively facilitate leadership trainings. Moreover, institutions have underinvested in the professional development of leadership educators, despite the significant role they play in shaping student leadership competencies. Through targeted investments in professional development, universities can better equip their leadership educators, thereby ensuring more effective mentorship and impactful leadership experiences for students. This article calls for a paradigm shift in leadership education, advocating for a strategic commitment to developing educators who can fulfill the promise of training the next generation of leaders.
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- 2024
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42. Toward Better Outcome Measurement for Insomnia in Children with Autism Spectrum Disorder
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Lawrence Scahill, Luc Lecavalier, Michael C. Edwards, Megan L. Wenzell, Leah M. Barto, Arielle Mulligan, Auscia T. Williams, Opal Ousley, Cynthia B. Sinha, Christopher A. Taylor, Soo Youn Kim, Laura M. Johnson, Scott E. Gillespie, and Cynthia R. Johnson
- Abstract
This report presents a new parent-rated outcome measure of insomnia for children with autism spectrum disorder. Parents of 1185 children with autism spectrum disorder (aged 3-12; 80.3% male) completed the first draft of the measure online. Factor and item response theory analyses reduced the set of 40 items to the final 21-item Pediatric Insomnia Autism Rating Scale. In this online sample, Pediatric Insomnia Autism Rating Scale mean was 21.8 ± 15.0 (range 0-63; coefficient alpha = 0.94). Item response theory results indicated excellent reliability across a range of scores. Next, we conducted a telehealth assessment of 134 children with autism spectrum disorder (aged 3-12; 73% male). In this clinical sample, Pediatric Insomnia Autism Rating Scale mean was 28.9 + 14.62 (range 0-61; coefficient alpha = 0.93). Pearson correlations of Pediatric Insomnia Autism Rating Scale with the PROMIS Sleep Disturbance and the modified Children's Sleep Habits Questionnaire was 0.74 for each. This was significantly higher than correlations of parent-rated disruptive behavior, hyperactivity, repetitive behavior, and anxiety measures (range 0.29-0.59)--supporting convergent and divergent validity. Parents of 63 children completed the Pediatric Insomnia Autism Rating Scale three times over 4 weeks. Intraclass correlation was excellent (0.88) over three time points. Pediatric Insomnia Autism Rating Scale is a valid dimensional measure of insomnia in autistic children that produces reliable scores.
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- 2024
- Full Text
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43. Teacher Participation in Young Children's Dramatic Play
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Sarah Young, Susan Edwards, and Joce Nuttall
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Socio-dramatic play is an everyday occurrence in early childhood education as children create narratives together in shared imagined worlds. The teacher's role in this type of play is less clear and this paper draws on a study using Lindqvist's "playworlds" approach to gain insight into how teachers participate in children's play. In applying Kravtsov and Kravtsova's concept of children's "double subjectivity" in dramatic play, the paper argues that teachers can also maintain dual affect roles--those of teacher outside the play, and co-player within the play--to co-create with children in their dramatic play narratives. In this study, four teachers in Melbourne, Australia participated in weekly playworlds with the researcher in their kindergarten rooms, resulting in identification of a third affect role for teachers--that of "public performer." This third affect was found to hinder teachers' capacity to maintain simultaneous subject positions of themselves as teacher and a co-player, thereby minimizing the improvised narrative trajectory and potential of the dramatic play. We argue this third affect should be acknowledged to support teacher participation in children's play.
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- 2024
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44. THE FIGHT INHERITED RETINAL BLINDNESS! PROJECT: A New Treatment Outcome and Natural History Registry for Inherited Retinal Disease.
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Simunovic, Matthew, Moore, Anthony, Grigg, John, Sergouniotis, Panagiotis, Mahroo, Omar, Vincent, Andrea, Singh, Mandeep, Fischer, M, Edwards, Thomas, Mack, Heather, Hogden, Michael, Chen, Fred, Hewitt, Alex, Ayton, Lauren, Leroy, Bart, Jamieson, Robyn, Gillies, Mark, and Barthelmes, Daniel
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Humans ,Registries ,Genetic Therapy ,Retinal Diseases ,Blindness - Abstract
PURPOSE: To design and build a new disease registry to track the natural history and outcomes of approved gene therapy in patients with inherited retinal diseases. METHODS: A core committee of six members was convened to oversee the construction of the Fight Inherited Retinal Blindness! module. A further 11 experts formed a steering committee, which discussed disease classification and variables to form minimum datasets using a consensus approach. RESULTS: The web-based Fight Inherited Retinal Blindness! registry records baseline demographic, clinical, and genetic data together with follow-up data. The Human Phenotype Ontology and Monarch Disease Ontology nomenclature were incorporated within the Fight Inherited Retinal Blindness! architecture to standardize nomenclature. The registry software assigns individual diagnoses to one of seven broad phenotypic groups, with minimum datasets dependent on the broad phenotypic group. In addition, minimum datasets were agreed on for patients undergoing approved gene therapy with voretigene neparvovec (Luxturna). New patient entries can be completed in 5 minutes, and follow-up data can be entered in 2 minutes. CONCLUSION: Fight Inherited Retinal Blindness! is an organized, web-based system that uses observational study methods to collect uniform data from patients with inherited retinal disease to track natural history and (uniquely) treatment outcomes. It is free to users who have control over their data.
- Published
- 2025
45. Improving explainability of post-separation suicide attempt prediction models for transitioning service members: insights from the Army Study to Assess Risk and Resilience in Servicemembers - Longitudinal Study.
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Edwards, Emily, Geraci, Joseph, Gildea, Sarah, Houtsma, Claire, Holdcraft, Jacob, Kennedy, Chris, King, Andrew, Luedtke, Alex, Marx, Brian, Naifeh, James, Sampson, Nancy, Stein, Murray, Ursano, Robert, and Kessler, Ronald
- Subjects
Humans ,Military Personnel ,Suicide ,Attempted ,Male ,Female ,Adult ,Longitudinal Studies ,Resilience ,Psychological ,Young Adult ,United States ,Machine Learning ,Risk Assessment ,Risk Factors - Abstract
Risk of U.S. Army soldier suicide-related behaviors increases substantially after separation from service. As universal prevention programs have been unable to resolve this problem, a previously reported machine learning model was developed using pre-separation predictors to target high-risk transitioning service members (TSMs) for more intensive interventions. This model is currently being used in a demonstration project. The model is limited, though, in two ways. First, the model was developed and trained in a relatively small cross-validation sample (n = 4044) and would likely be improved if a larger sample was available. Second, the model provides no guidance on subtyping high-risk TSMs. This report presents results of an attempt to refine the model to address these limitations by re-estimating the model in a larger sample (n = 5909) and attempting to develop embedded models for differential risk of post-separation stressful life events (SLEs) known to mediate the association of model predictions with post-separation nonfatal suicide attempts (SAs; n = 4957). Analysis used data from the Army STARRS Longitudinal Surveys. The revised model improved prediction of post-separation SAs in the first year (AUC = 0.85) and second-third years (AUC = 0.77) after separation, but embedded models could not predict post-separation SLEs with enough accuracy to support intervention targeting.
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- 2025
46. Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).
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Bellos, Evangelos, Santillo, Dilys, Vantourout, Pierre, Jackson, Heather, Duret, Amedine, Hearn, Henry, Seeleuthner, Yoann, Talouarn, Estelle, Hodeib, Stephanie, Patel, Harsita, Powell, Oliver, Yeoh, Sophya, Mustafa, Sobia, Habgood-Coote, Dominic, Nichols, Samuel, Estramiana Elorrieta, Leire, DSouza, Giselle, Wright, Victoria, Estrada-Rivadeneyra, Diego, Tremoulet, Adriana, Dummer, Kirsten, Netea, Stejara, Condino-Neto, Antonio, Lau, Yu, Núñez Cuadros, Esmeralda, Toubiana, Julie, Holanda Pena, Marisol, Rieux-Laucat, Frédéric, Luyt, Charles-Edouard, Haerynck, Filomeen, Mège, Jean, Chakravorty, Samya, Haddad, Elie, Morin, Marie-Paule, Metin Akcan, Özge, Keles, Sevgi, Emiroglu, Melike, Alkan, Gulsum, Tüter Öz, Sadiye, Elmas Bozdemir, Sefika, Morelle, Guillaume, Volokha, Alla, Kendir-Demirkol, Yasemin, Sözeri, Betul, Coskuner, Taner, Yahsi, Aysun, Gulhan, Belgin, Kanik-Yuksek, Saliha, Bayhan, Gulsum, Ozkaya-Parlakay, Aslinur, Yesilbas, Osman, Hatipoglu, Nevin, Ozcelik, Tayfun, Belot, Alexandre, Chopin, Emilie, Barlogis, Vincent, Sevketoglu, Esra, Menentoglu, Emin, Gayretli Aydin, Zeynep, Bloomfield, Marketa, AlKhater, Suzan, Cyrus, Cyril, Stepanovskiy, Yuriy, Bondarenko, Anastasiia, Öz, Fatma, Polat, Meltem, Fremuth, Jiří, Lebl, Jan, Geraldo, Amyrath, Jouanguy, Emmanuelle, Carter, Michael, Wellman, Paul, Peters, Mark, Pérez de Diego, Rebeca, Edwards, Lindsey, Chiu, Christopher, Noursadeghi, Mahdad, Bolze, Alexandre, Shimizu, Chisato, Kaforou, Myrsini, Hamilton, Melissa, Herberg, Jethro, Schmitt, Erica, Rodriguez-Palmero, Agusti, Pujol, Aurora, Kim, Jihoon, Cobat, Aurélie, Abel, Laurent, Zhang, Shen-Ying, Casanova, Jean-Laurent, Kuijpers, Taco, Burns, Jane, Levin, Michael, Hayday, Adrian, and Sancho-Shimizu, Vanessa
- Subjects
Humans ,COVID-19 ,Child ,Systemic Inflammatory Response Syndrome ,Male ,Female ,Butyrophilins ,SARS-CoV-2 ,Child ,Preschool ,Heterozygote ,Adolescent ,Genetic Predisposition to Disease ,Infant - Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, burdenMC, which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.2, 95% CI: 3.5-5.3, P < 10-6). BTNL8 encodes an intestinal epithelial regulator of Vγ4+γδ T cells implicated in regulating gut homeostasis. Enrichment was exclusive to MIS-C, being absent in patients with COVID-19 or bacterial disease. Using an available functional test for BTNL8, rare variants from a larger cohort of MIS-C patients (n = 835) were tested which identified eight variants in 18 patients (2.2%) with impaired engagement of Vγ4+γδ T cells. Most of these variants were in the B30.2 domain of BTNL8 implicated in sensing epithelial cell status. These findings were associated with altered intestinal permeability, suggesting a possible link between disrupted gut homeostasis and MIS-C-associated enteropathy triggered by SARS-CoV-2.
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- 2024
47. Artificial intelligence in food and nutrition evidence: The challenges and opportunities.
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Bailey, Regan, MacFarlane, Amanda, Field, Martha, Tagkopoulos, Ilias, Baranzini, Sergio, Edwards, Kristen, Rose, Christopher, Schork, Nicholas, Singhal, Akshat, Wallace, Byron, Fisher, Kelly, Markakis, Konstantinos, and Stover, Patrick
- Subjects
artificial intelligence ,computed evidence ,evidence synthesis ,nutrition ,systematic reviews - Abstract
Science-informed decisions are best guided by the objective synthesis of the totality of evidence around a particular question and assessing its trustworthiness through systematic processes. However, there are major barriers and challenges that limit science-informed food and nutrition policy, practice, and guidance. First, insufficient evidence, primarily due to acquisition cost of generating high-quality data, and the complexity of the diet-disease relationship. Furthermore, the sheer number of systematic reviews needed across the entire agriculture and food value chain, and the cost and time required to conduct them, can delay the translation of science to policy. Artificial intelligence offers the opportunity to (i) better understand the complex etiology of diet-related chronic diseases, (ii) bring more precision to our understanding of the variation among individuals in the diet-chronic disease relationship, (iii) provide new types of computed data related to the efficacy and effectiveness of nutrition/food interventions in health promotion, and (iv) automate the generation of systematic reviews that support timely decisions. These advances include the acquisition and synthesis of heterogeneous and multimodal datasets. This perspective summarizes a meeting convened at the National Academy of Sciences, Engineering, and Medicine. The purpose of the meeting was to examine the current state and future potential of artificial intelligence in generating new types of computed data as well as automating the generation of systematic reviews to support evidence-based food and nutrition policy, practice, and guidance.
- Published
- 2024
48. Hierarchical domain structures in buckled ferroelectric free sheets
- Author
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Pesquera, David, Cordero-Edwards, Kumara, Checa, Marti, Ivanov, Ilia, Casals, Blai, Rosado, Marcos, Caicedo, José Manuel, Casado-Zueras, Laura, Pablo-Navarro, Javier, Magén, César, Santiso, José, Domingo, Neus, Catalan, Gustau, and Sandiumenge, Felip
- Subjects
Condensed Matter - Materials Science - Abstract
Flat elastic sheets tend to display wrinkles and folds. From pieces of clothing down to two-dimensional crystals, these corrugations appear in response to strain generated by sheet compression or stretching, thermal or mechanical mismatch with other elastic layers, or surface tension. Extensively studied in metals, polymers and, more recently, in van der Waals exfoliated layers, with the advent of thin single crystal freestanding films of complex oxides, researchers are now paying attention to novel microstructural effects induced by bending ferroelectric-ferroelastics, where polarization is strongly coupled to lattice deformation. Here we show that wrinkle undulations in BaTiO3 sheets bonded to a viscoelastic substrate transform into a buckle delamination geometry when transferred onto a rigid substrate. Using spatially resolved techniques at different scales (Raman, scanning probe and electron microscopy), we show how these delaminations in the free BaTiO3 sheets display a self-organization of ferroelastic domains along the buckle profile that strongly differs from the more studied sinusoidal wrinkle geometry. Moreover, we disclose the hierarchical distribution of a secondary set of domains induced by the misalignment of these folding structures from the preferred in-plane crystallographic orientations. Our results disclose the relevance of the morphology and orientation of buckling instabilities in ferroelectric free sheets, for the stabilization of different domain structures, pointing to new routes for domain engineering of ferroelectrics in flexible oxide sheets.
- Published
- 2024
49. Capstone Experiences in Developing Augmented Reality Tables for Community Organizations
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Edwards, H. Keith, Peterson, Michael R., and Cristobal, Francis
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Computer Science - Computers and Society - Abstract
This paper examines two senior capstone experiences developed as augmented reality tables over the past two years. Both projects were public facing efforts that required working implementations. The first project was deployed at an astronomy center and focused on interactions between land use and ecological aspects of Hawaii Island while the second project focused more on historical sites on the same island. Both projects leveraged brownfield development and existing code bases to allow for student success in spite of the impacts of the COVID19 pandemic., Comment: From The 18th International Conference on Frontiers in Education: Computer Science & Computer Engineering (FECS) 6 Pages
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- 2024
50. All-passive upconversion imaging of incoherent near-infrared light at intensities down to 50 nW/cm$^2$
- Author
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Hamid, Rabeeya, Feng, Demeng, Narayanan, Pournima, Edwards, Justin S., Hu, Manchen, Belliveau, Emma, Kim, Minjeong, Deshpande, Sanket, Wan, Chenghao, Pucurimay, Linda, Czaplewski, David A., Congreve, Daniel N., and Kats, Mikhail A.
- Subjects
Physics - Optics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
Frequency upconversion, which converts low-energy photons into higher-energy ones, typically requires intense coherent illumination to drive nonlinear processes or the use of externally driven optoelectronic devices. Here, we demonstrate a high-resolution upconversion imaging system that converts low-intensity (down to 50 nW/cm$^2$) incoherent near-infrared (NIR) light into the visible, reaching intensities perceptible by the human eye, without the use of any external power input. Our upconverting element is enabled by the following ingredients: (1) photon upconversion via triplet-triplet annihilation in a bulk heterojunction of the organic semiconductors Y6 and rubrene; (2) plasmonic enhancement of absorption and field intensity in the heterojunction layer; (3) collection enhancement using a dichroic thin-film assembly. The upconverting element is inserted at an intermediate image plane of a dual-wavelength telescope system, which preserves the relative directionality of rays between the incident NIR light and output visible light. Our all-passive upconversion imaging system will enable NIR imaging and sensing in low-light environments under energy constraints., Comment: Main text + supplementary
- Published
- 2024
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