Search

Your search keyword '"Eeltink, Corien M."' showing total 22 results
Start Over Author "Eeltink, Corien M."
22 results on '"Eeltink, Corien M."'

7. Nursing Issues

Author

Eeltink, Corien M., Beumer-Grootenhuis, Angelina, Burghout, Carolien, Wedding, Ulrich, editor, and Audisio, Riccardo A., editor

Published
2015
Full Text
View/download PDF

9. Nursing Issues

Author

Eeltink, Corien M., primary, Beumer-Grootenhuis, Angelina, additional, and Burghout, Carolien, additional

Published
2014
Full Text
View/download PDF

14. A randomized controlled trial on the efficacy of life review therapy targeting incurably ill cancer patients: do their informal caregivers benefit?

Author

Kleijn, Gitta, primary, Lissenberg-Witte, Birgit I., additional, Bohlmeijer, Ernst T., additional, Willemsen, Vincent, additional, Becker-Commissaris, Annemarie, additional, Eeltink, Corien M., additional, Bruynzeel, Anna M.E., additional, van der Vorst, Maurice J., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional

Published
2020
Full Text
View/download PDF

16. The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative care: A randomized controlled trial

Author

Kleijn, Gitta, primary, Lissenberg-Witte, Birgit I., additional, Bohlmeijer, Ernst T., additional, Steunenberg, Bas, additional, Knipscheer-Kuijpers, Kitty, additional, Willemsen, Vincent, additional, Becker, Annemarie, additional, Smit, Egbert F., additional, Eeltink, Corien M., additional, Bruynzeel, Anna M. E., additional, van der Vorst, Maurice, additional, de Bree, Remco, additional, Leemans, C. René, additional, van den Brekel, Michiel W. M., additional, Cuijpers, Pim, additional, and Verdonck-de Leeuw, Irma M., additional

Published
2018
Full Text
View/download PDF

17. Health-care professionals’ perspective on discussing sexual issues in adult patients after haematopoietic cell transplantation

Author

Eeltink, Corien M., primary, Witte, Birgit I., additional, Stringer, Jacqui, additional, Liptrott, Sarah, additional, Babic, Aleksandra, additional, Greenfield, Diana M., additional, Salooja, Nina, additional, Incrocci, Luca, additional, Visser, Otto, additional, Verdonck-de Leeuw, Irma M., additional, Duarte, Rafael F., additional, and Zweegman, Sonja, additional

Published
2017
Full Text
View/download PDF

20. Feasibility and Efficacy of Dose Adjusted Melphalan - Prednisone - Bortezomib (MPV) in Elderly Patients ≥ 75 Years of Age with Newly Diagnosed Multiple Myeloma; the Non-Randomised Phase II HOVON 123 Study

Author

Zweegman, Sonja, primary, Levin, Mark-David, additional, Klein, Saskia K., additional, De Waal, Esther G.M., additional, Eeltink, Corien M., additional, Ypma, Paula F., additional, Dijk, Amanda C., additional, Westerman, Matthijs, additional, Deenik, Wendy, additional, Tanis, Bea, additional, Slee-Valentijn, Monique S., additional, Minnema, Monique, additional, Visser-Wisselaar, Heleen, additional, Stege, Claudia, additional, van de Donk, Niels W.C.J., additional, Nasserinejad, Kazem, additional, and Sonneveld, Pieter, additional

Published
2016
Full Text
View/download PDF

22. Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.

Author

Chamuleau ME, Westers TM, van Dreunen L, Groenland J, Zevenbergen A, Eeltink CM, Ossenkoppele GJ, and van de Loosdrecht AA

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Immunity, Innate, Immunologic Surveillance, Male, Middle Aged, T-Lymphocytes immunology, Autoimmunity, Cytotoxicity, Immunologic immunology, Hematopoietic Stem Cells immunology, Myelodysplastic Syndromes immunology
Abstract

Background: An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. On the one hand an activated and skewed T-cell repertoire has been reported, but on the other hand, decreased natural killer cell function has been found. Immune activation could reflect undesired autoimmune reactions against normal hematopoietic precursor cells as well as effective immune-surveillance against dysplastic clones., Design and Methods: We have investigated immune effector cells (lymphocyte subsets, lymphocyte activation markers, and natural killer cells) of 40 low and intermediate risk myelodysplastic syndrome patients and compared them to those of 10 age-matched healthy donors. Furthermore, we have analyzed the cytotoxic capacity of effector cells against autologous bone marrow hematopoietic precursor cells of 8 myelodysplastic syndrome patients and 2 healthy donors., Results: In myelodysplastic syndrome patients, we have found an activated state of lymphocytes, determined by increased percentages of effector T cells with cytotoxic profile, more skewing of the T-cell receptor Vbeta (TCR-Vbeta) repertoire, and decreased frequencies of regulatory T cells, when compared to healthy donors. The percentage of natural killer cells did not differ between myelodysplastic syndrome patients and healthy donors, but natural killer cells of myelodysplastic syndrome patients expressed increased levels of granzyme B. Finally, we have demonstrated non-MHC restricted autologous cytotoxicity up to 90% against aberrant hematopoietic precursor cells, presumably mediated by natural killer cells., Conclusions: Our data point to a role for active immune-surveillance in myelodysplastic syndrome, as demonstrated by activated T cells and TCR-Vss skewing. Autologous cytotoxicity against hematopoietic precursor cells was natural killer cell dependent, which points to an additional role for the innate immune system in immune-surveillance of myelodysplastic syndrome patients.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results