1,120 results on '"Efferth, T."'
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2. Ovarian and uterine functions in female albino rats fed dietary meal supplemented with Mucuna pruriens (L.) DC. seed powder
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Ashidi JS, Owagboriaye FO, Lawal OI, Houghton PJ, and Efferth T
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fertility ,oestradiol ,ovary ,mucuna pruriens ,reproductive hormones ,steroidogenic enzyme ,uterus ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: While the reproduction-enhancing property of Mucuna pruriens (MP) seed has been widely studied in males, little is known about this property in females despite the rate at which the seed is consumed by both sexes worldwide. Objective: To determine the effect of MP seed powder in dietary inclusion on ovarian and uterine functions of adult female albino rats. Methods: The rats were randomised into four groups. Group 1 (Control) was given standard rat chow (15g of feed/rat/day only) while groups 2, 3 and 4 were fed diets supplemented with MP seed powder at 0.75 g, 1.5g and 2.25g/day, respectively, for 12 weeks. Serum levels of oestradiol, follicle stimulating hormone, luteinising hormone, ovarian Δ5, 3β- hydroxysteroid dehydrogenase (Δ5, 3β-HSD) and 17 β hydroxysteroid dehydrogenase (17β-HSD) activities, ovarian and uterine peroxidase and tissue cytoarchitectural structures were used as diagnostic markers of reproductive function. Results: Significant increases in the serum level of all hormones including ovarian Δ5, 3β-HSD, 17β-HSD activities, ovarian and uterine peroxidase activities, and improvement of the ovarian and uterine cytoarchitectural integrity of the rats fed MP at 0.75g/day compared to other groups were observed. However, MP at 2.25g/day induced reproductive dysfunction characterised by significant reductions in hormones, uterine and ovarian enzyme activities, severe degenerative cytoarchitectural lesions in tissues. Conclusions: MP seed improves uterine and ovarian functions at a dose level of 0.75g/day, but a higher dose value may be toxic.
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- 2022
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3. Metastasis of cisplatin-resistant bladder cancer cells is impaired by artesunate through inhibition of integrin subtypes
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Vakhrusheva, O., primary, Zhao, F., additional, Markowitsch, S.D., additional, Slade, K.S., additional, Mager, R., additional, Cinatl Jr., J., additional, Michaelis, M., additional, Efferth, T., additional, Haferkamp, A., additional, and Jüngel, E., additional
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- 2022
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4. Natural products in drug discovery: advances and opportunities
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Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T., Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., and Supuran, C. T.
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0301 basic medicine ,Engineering ,Drug Industry ,Review Article ,Communicable Diseases ,Natural (archaeology) ,03 medical and health sciences ,0302 clinical medicine ,Transferases ,Neoplasms ,Drug Discovery ,Humans ,Pharmaceutical industry ,Pharmacology ,Biological Products ,Natural products ,Genome ,business.industry ,Drug discovery ,General Medicine ,Chemical biology ,030104 developmental biology ,Risk analysis (engineering) ,030220 oncology & carcinogenesis ,Genome mining ,business - Abstract
The International Natural Product Sciences Taskforce: et al., Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities., A.C. and E.I. thank the Ministerio de Ciencia, Innovación y Universidades, Spain (Project AGL2017-89417-R) for support. F.A.M. acknowledges the support by Ministerio de Economia y Competitividad, Spain (project AGL2017-88083-R).
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- 2021
5. Substanzklassen und Wirkmechanismen
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Efferth, T., Osieka, R., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor
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- 2006
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6. Die Reduktion von Integrin α6 durch Artesunat inhibiert das progressive Wachstum Docetaxel-resistenter Prostatakarzinomzellen
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Bräunig, V, Stein, L, Wüstefeld, L, Vakhrusheva, O, Markowitsch, S, Slade, K, Efferth, T, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Haferkamp, A, and Jüngel, E
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Therapieresistenzen stellen eines der größten Probleme in der Behandlung des fortgeschrittenen Prostatakarzinom (PCa), dem häufigsten Tumor des Mannes, dar. Neue Behandlungskonzepte werden daher dringend gesucht. Artesunat (ART) aus der Traditionellen Chinesischen Medizin [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
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7. Artesunat hemmt signifikant das Metastasierungsverhalten Cisplatin-resistenter Harnblasenkarzinomzellen
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Vakhrusheva, O., Zhao, F., Markowitsch, S., Michaelis, M., Cinatl, J., Efferth, T., Haferkamp, A., and Jüngel, E.
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Zur Standardtherapie des metastasierten Harnblasenkarzinom (BCa) gehört die Cisplatin-basierte Chemotherapie. Das Therapieansprechen ist jedoch limitiert, so dass es zum Rezidiv kommt oder die Erkrankung in einen invasiven bzw. systemischen Progress fortschreitet. Dafür maßgeblich [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
8. Shikonin reguliert den AKT/mTOR-Signalweg und induziert die Nekroptose bei Sunitinib-resistenten NZK-Zellen
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Markowitsch, S., Vakhrusheva, O., Schupp, P., Akele, Y., Kitanovic, J., Efferth, T., Haferkamp, A., and Jüngel, E.
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Neue zielgerichtete Therapien verbesserten die Prognose von Patienten mit einem fortgeschrittenen Nierenzellkarzinom (NZK). Problematisch bleibt, dass die Wirkung durch Resistenzen limitiert ist und die etablierten Behandlungen somit von einem palliativen Charakter geprägt sind. Shikonin [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
9. Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid
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Wang W, Luo M, Fu Y, Wang S, Efferth T, and Zu Y
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Medicine (General) ,R5-920 - Abstract
Wei Wang,1–3 Meng Luo,1–3 Yujie Fu,1–3 Song Wang,1–3 Thomas Efferth,4 Yuangang Zu1–3 1Key Laboratory of Forest Plant Ecology, 2Engineering Research Center of Forest Bio-Preparation, 3State Engineering Laboratory of Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, China; 4Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz, Germany Abstract: Glycyrrhizic acid (GA), the main component of radix glycyrrhizae, has a variety of pharmacological activities. In the present study, suspensions of GA nanoparticles with the average particle size about 200nm were prepared by a supercritical antisolvent (SAS) process. Comparative studies were undertaken using lipopolysaccardide(LPS)-stimulated mouse macrophages RAW 264.7 as in vitro inflammatory model. Several important inflammation mediators such as NO, PGE2, TNF-α and IL-6 were examined. These markers were highly stimulated by LPS and were inhibited both by nano-GA and unprocessed GA in a dose-dependent manner, especially PGE2 and TNF-α. However nano-GA and unprocessed GA inhibited NO only at a high concentration. In general, we found that GA nanoparticle suspensions exhibited much better anti-inflammatory activities compared to unprocessed GA. Keywords: glycyrrhizic acid, nanoparticle, mouse macrophages RAW 264.7, inflammatory cytokines
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- 2013
10. Antineoplastische Substanzen
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Osieka, R., Efferth, T., Borner, M., Cerny, T., Sauter, H., Barth, J., Schneemann, H., Paul, H., Sauer, H., Illiger, H.-J., Bornmann, L., Laupert, A., Illiger, H.-L., Berdel, W. E., Schmoll, H.-J., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor
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- 1996
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11. Artesunate inhibits the progressive growth behavior of docetaxel-resistant prostate cancer cells
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Jüngel, E., primary, Vakhrusheva, O., additional, Erb, H.H.H., additional, Braeunig, V., additional, Markowitsch, S.D., additional, Schupp, P., additional, Slade, K.S., additional, Thomas, A., additional, Tsaur, I., additional, Puhr, M., additional, Culig, Z., additional, Cinatl Jr., J., additional, Michaelis, M., additional, Efferth, T., additional, and Haferkamp, A., additional
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- 2021
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12. Artesunat hemmt in Nierenzellkarzinomzellen das Wachstum und die metabolische Aktivität
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Markowitsch, S., Schupp, P., Lauckner, J., Vakhrusheva, O., Slade, K., Mager, R., Efferth, T., Haferkamp, A., and Jüngel, E.
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Neue zielgerichtete Therapien verbessern die Prognose des Nierenzellkarzinoms (NZK). Limitiert wird der Behandlungserfolg jedoch durch Therapieresistenzen. Die Entwicklung neuer innovativer Therapieoptionen ist daher notwendig. Naturstoffe rücken dabei als Additivum vermehrt in den [zum vollständigen Text gelangen Sie über die oben angegebene URL], 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.
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- 2021
13. Shikonin aus der Traditionellen Chinesischen Medizin inhibiert das progressive Wachstum Docetaxel-resistenter Prostatakarzinome in vitro
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Jüngel, E, Markowitsch, S, Juetter, K, Schupp, P, Hauschulte, K, Vakhrusheva, O, Slade, K, Thomas, A, Tsaur, I, Cinatl, J, Michaelis, M, Efferth, T, and Haferkamp, A
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Das Prostatakarzinom (PCa) ist noch immer der häufigste Tumor des Mannes. Die Wirksamkeit der zugelassenen Therapeutika ist durch die Entstehung von Therapieresistenzen zeitlich limitieren. Neue Therapiekonzepte werden daher weiterhin dringend gesucht. Shikonin (SHI) aus der Traditionellen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.
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- 2021
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14. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, MA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, GD, Altan-Bonnet, N, Altieri, DC, Álvarez, ÉMC, Alves, S, Alves da Costa, C, Alzaharna, MM, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, AO, Ammanathan, V, An, Z, Andersen, SU, Andrabi, SA, Andrade-Silva, M, Andres, AM, Angelini, S, Ann, D, Anozie, UC, Ansari, MY, Antas, P, Antebi, A, Antón, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araújo, WL, Araya, J, Arden, C, Arévalo, M-A, Arguelles, S, Arias, E, Arikkath, J, Arimoto, H, Ariosa, AR, Armstrong-James, D, Arnauné-Pelloquin, L, Aroca, A, Arroyo, DS, Arsov, I, Artero, R, Asaro, DML, Aschner, M, Ashrafizadeh, M, Ashur-Fabian, O, Atanasov, AG, Au, AK, Auberger, P, Auner, HW, Aurelian, L, Autelli, R, Avagliano, L, Ávalos, Y, Aveic, S, Aveleira, CA, Avin-Wittenberg, T, Aydin, Y, Ayton, S, Ayyadevara, S, Azzopardi, M, Baba, M, Backer, JM, Backues, SK, Bae, D-H, Bae, O-N, Bae, SH, Baehrecke, EH, Baek, A, Baek, S-H, Baek, SH, Bagetta, G, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, X, Bai, Y, Bairagi, N, Baksi, S, Balbi, T, Baldari, CT, Balduini, W, Ballabio, A, Ballester, M, Balazadeh, S, Balzan, R, Bandopadhyay, R, Banerjee, S, Bánréti, Á, Bao, Y, Baptista, MS, Baracca, A, Barbati, C, Bargiela, A, Barilà, D, Barlow, PG, Barmada, SJ, Barreiro, E, Barreto, GE, Bartek, J, Bartel, B, Bartolome, A, Barve, GR, Basagoudanavar, SH, Bassham, DC, Bast, RC, Basu, A, Batoko, H, Batten, I, Baulieu, EE, Baumgarner, BL, Bayry, J, Beale, R, Beau, I, Beaumatin, F, Bechara, LRG, Beck, GR, Beers, MF, Begun, J, Behrends, C, Behrens, GMN, Bei, R, Bejarano, E, Bel, S, Behl, C, Belaid, A, Belgareh-Touzé, N, Bellarosa, C, Belleudi, F, Belló Pérez, M, Bello-Morales, R, Beltran, JSDO, Beltran, S, Benbrook, DM, Bendorius, M, Benitez, BA, Benito-Cuesta, I, Bensalem, J, Berchtold, MW, Berezowska, S, Bergamaschi, D, Bergami, M, Bergmann, A, Berliocchi, L, Berlioz-Torrent, C, Bernard, A, Berthoux, L, Besirli, CG, Besteiro, S, Betin, VM, Beyaert, R, Bezbradica, JS, Bhaskar, K, Bhatia-Kissova, I, Bhattacharya, R, Bhattacharya, S, Bhattacharyya, S, Bhuiyan, MS, Bhutia, SK, Bi, L, Bi, X, Biden, TJ, Bijian, K, Billes, VA, Binart, N, Bincoletto, C, Birgisdottir, AB, Bjorkoy, G, Blanco, G, Blas-Garcia, A, Blasiak, J, Blomgran, R, Blomgren, K, Blum, JS, Boada-Romero, E, Boban, M, Boesze-Battaglia, K, Boeuf, P, Boland, B, Bomont, P, Bonaldo, P, Bonam, SR, Bonfili, L, Bonifacino, JS, Boone, BA, Bootman, MD, Bordi, M, Borner, C, Bornhauser, BC, Borthakur, G, Bosch, J, Bose, S, Botana, LM, Botas, J, Boulanger, CM, Boulton, ME, Bourdenx, M, Bourgeois, B, Bourke, NM, Bousquet, G, Boya, P, Bozhkov, PV, Bozi, LHM, Bozkurt, TO, Brackney, DE, Brandts, CH, Braun, RJ, Braus, GH, Bravo-Sagua, R, Bravo-San Pedro, JM, Brest, P, Bringer, M-A, Briones-Herrera, A, Broaddus, VC, Brodersen, P, Brodsky, JL, Brody, SL, Bronson, PG, Bronstein, JM, Brown, CN, Brown, RE, Brum, PC, Brumell, JH, Brunetti-Pierri, N, Bruno, D, Bryson-Richardson, RJ, Bucci, C, Buchrieser, C, Bueno, M, Buitrago-Molina, LE, Buraschi, S, Buch, S, Buchan, JR, Buckingham, EM, Budak, H, Budini, M, Bultynck, G, Burada, F, Burgoyne, JR, Burón, MI, Bustos, V, Büttner, S, Butturini, E, Byrd, A, Cabas, I, Cabrera-Benitez, S, Cadwell, K, Cai, J, Cai, L, Cai, Q, Cairó, M, Calbet, JA, Caldwell, GA, Caldwell, KA, Call, JA, Calvani, R, Calvo, AC, Calvo-Rubio Barrera, M, Camara, NO, Camonis, JH, Camougrand, N, Campanella, M, Campbell, EM, Campbell-Valois, F-X, Campello, S, Campesi, I, Campos, JC, Camuzard, O, Cancino, J, Candido de Almeida, D, Canesi, L, Caniggia, I, Canonico, B, Cantí, C, Cao, B, Caraglia, M, Caramés, B, Carchman, EH, Cardenal-Muñoz, E, Cardenas, C, Cardenas, L, Cardoso, SM, Carew, JS, Carle, GF, Carleton, G, Carloni, S, Carmona-Gutierrez, D, Carneiro, LA, Carnevali, O, Carosi, JM, Carra, S, Carrier, A, Carrier, L, Carroll, B, Carter, AB, Carvalho, AN, Casanova, M, Casas, C, Casas, J, Cassioli, C, Castillo, EF, Castillo, K, Castillo-Lluva, S, Castoldi, F, Castori, M, Castro, AF, Castro-Caldas, M, Castro-Hernandez, J, Castro-Obregon, S, Catz, SD, Cavadas, C, Cavaliere, F, Cavallini, G, Cavinato, M, Cayuela, ML, Cebollada Rica, P, Cecarini, V, Cecconi, F, Cechowska-Pasko, M, Cenci, S, Ceperuelo-Mallafré, V, Cerqueira, JJ, Cerutti, JM, Cervia, D, Cetintas, VB, Cetrullo, S, Chae, H-J, Chagin, AS, Chai, C-Y, Chakrabarti, G, Chakrabarti, O, Chakraborty, T, Chami, M, Chamilos, G, Chan, DW, Chan, EYW, Chan, ED, Chan, HYE, Chan, HH, Chan, H, Chan, MTV, Chan, YS, Chandra, PK, Chang, C-P, Chang, C, Chang, H-C, Chang, K, Chao, J, Chapman, T, Charlet-Berguerand, N, Chatterjee, S, Chaube, SK, Chaudhary, A, Chauhan, S, Chaum, E, Checler, F, Cheetham, ME, Chen, C-S, Chen, G-C, Chen, J-F, Chen, LL, Chen, L, Chen, M, Chen, M-K, Chen, N, Chen, Q, Chen, R-H, Chen, S, Chen, W, Chen, X-M, Chen, X-W, Chen, X, Chen, Y, Chen, Y-G, Chen, Y-J, Chen, Y-Q, Chen, ZS, Chen, Z, Chen, Z-H, Chen, ZJ, Cheng, H, Cheng, J, Cheng, S-Y, Cheng, W, Cheng, X, Cheng, X-T, Cheng, Y, Cheng, Z, Cheong, H, Cheong, JK, Chernyak, BV, Cherry, S, Cheung, CFR, Cheung, CHA, Cheung, K-H, Chevet, E, Chi, RJ, Chiang, AKS, Chiaradonna, F, Chiarelli, R, Chiariello, M, Chica, N, Chiocca, S, Chiong, M, Chiou, S-H, Chiramel, AI, Chiurchiù, V, Cho, D-H, Choe, S-K, Choi, AMK, Choi, ME, Choudhury, KR, Chow, NS, Chu, CT, Chua, JP, Chua, JJE, Chung, H, Chung, KP, Chung, S, Chung, S-H, Chung, Y-L, Cianfanelli, V, Ciechomska, IA, Cifuentes, M, 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Davis, T, Dayalan Naidu, S, De Amicis, F, De Bosscher, K, De Felice, F, De Franceschi, L, De Leonibus, C, de Mattos Barbosa, MG, De Meyer, GRY, De Milito, A, De Nunzio, C, De Palma, C, De Santi, M, De Virgilio, C, De Zio, D, Debnath, J, DeBosch, BJ, Decuypere, J-P, Deehan, MA, Deflorian, G, DeGregori, J, Dehay, B, Del Rio, G, Delaney, JR, Delbridge, LMD, Delorme-Axford, E, Delpino, MV, Demarchi, F, Dembitz, V, Demers, ND, Deng, H, Deng, Z, Dengjel, J, Dent, P, Denton, D, DePamphilis, ML, Der, CJ, Deretic, V, Descoteaux, A, Devis, L, Devkota, S, Devuyst, O, Dewson, G, Dharmasivam, M, Dhiman, R, di Bernardo, D, Di Cristina, M, Di Domenico, F, Di Fazio, P, Di Fonzo, A, Di Guardo, G, Di Guglielmo, GM, Di Leo, L, Di Malta, C, Di Nardo, A, Di Rienzo, M, Di Sano, F, Diallinas, G, Diao, J, Diaz-Araya, G, Díaz-Laviada, I, Dickinson, JM, Diederich, M, Dieudé, M, Dikic, I, Ding, S, Ding, W-X, Dini, L, Dinić, J, Dinic, M, Dinkova-Kostova, AT, Dionne, MS, Distler, JHW, Diwan, A, Dixon, IMC, 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- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
15. Overexpression of P-Glycoprotein in Human Lung Carcinoma Xenografts after Fractionated Irradiation in Vivo
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Mattern, J., Efferth, T., and Volm, M.
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- 1991
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16. Natural products in drug discovery: advances and opportunities
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Atanasov, A.G. Zotchev, S.B. Dirsch, V.M. Orhan, I.E. Banach, M. Rollinger, J.M. Barreca, D. Weckwerth, W. Bauer, R. Bayer, E.A. Majeed, M. Bishayee, A. Bochkov, V. Bonn, G.K. Braidy, N. Bucar, F. Cifuentes, A. D’Onofrio, G. Bodkin, M. Diederich, M. Dinkova-Kostova, A.T. Efferth, T. El Bairi, K. Arkells, N. Fan, T.-P. Fiebich, B.L. Freissmuth, M. Georgiev, M.I. Gibbons, S. Godfrey, K.M. Gruber, C.W. Heer, J. Huber, L.A. Ibanez, E. Kijjoa, A. Kiss, A.K. Lu, A. Macias, F.A. Miller, M.J.S. Mocan, A. Müller, R. Nicoletti, F. Perry, G. Pittalà, V. Rastrelli, L. Ristow, M. Russo, G.L. Silva, A.S. Schuster, D. Sheridan, H. Skalicka-Woźniak, K. Skaltsounis, L. Sobarzo-Sánchez, E. Bredt, D.S. Stuppner, H. Sureda, A. Tzvetkov, N.T. Vacca, R.A. Aggarwal, B.B. Battino, M. Giampieri, F. Wink, M. Wolfender, J.-L. Xiao, J. Yeung, A.W.K. Lizard, G. Popp, M.A. Heinrich, M. Berindan-Neagoe, I. Stadler, M. Daglia, M. Verpoorte, R. Supuran, C.T. the International Natural Product Sciences Taskforce
- Abstract
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities. © 2021, Springer Nature Limited.
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- 2021
17. Krebshemmende Wirkung des ätherischen Salbei-Öls auf eine Plattenepithelzellkarzinom-Zelllinie der Mundhöhle (UMSCC1)
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Sertel, S., Eichhorn, T., Plinkert, P.K., and Efferth, T.
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- 2011
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18. Objectifying acupuncture effects by lung function and numeric rating scale in patients undergoing heart surgery
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Maimer, A., Remppis, A., Sack, F. U., Ringes-Lichtenberg, S., Greten, T., Brazkiewicz, F., Schröder, S., Goncalves, M., Efferth, T., Greten, H. J., and Valentini, Jan
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- 2013
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19. Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells
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Hamm, R., Chen, Y.-R., Seo, Ean-Jeong, Zeino, Maen, Wu, Ching-Fen, Müller, R., Yang, N.-S., and Efferth, T.
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- 2014
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20. Identification of mitochondrial and PI3K-Akt-mTOR pathways as targets of naphtoquinones in cancer cells by pharmacogenomics: ID 052
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Wiench, B., Chen, Y.-R., Eichhorn, T., Paulsen, M., Hamm, R., Yang, N.-S., and Efferth, T.
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- 2014
21. Lipid rafts play an important role in the vesicular stomatitis virus life cycle
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Wang, W., Fu, Y. J., Zu, Y. G., Wu, N., Reichling, J., and Efferth, T.
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- 2009
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22. The role of copper in drug-resistant murine and human tumors
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Majumder, S., Chatterjee, S., Pal, Smarajit, Biswas, J., Efferth, T., and Choudhuri, Soumitra Kumar
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- 2009
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23. Synthesis of novel xanthone and acridone carboxamides with potent antiproliferative activities
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Georgakopoulos, A. Kalampaliki, A.D. Gioti, K. Hamdoun, S. Giannopoulou, A.F. Efferth, T. Stravopodis, D.J. Tenta, R. Marakos, P. Pouli, N. Kostakis, I.K.
- Abstract
Several new amino-substituted acridone and xanthone derivatives have been designed and synthesized, using an efficient methodology from suitable acridone- or xanthone-carboxylic acid intermediates. The antiproliferative activity of the target compounds has been evaluated against four cancer cell lines, namely breast adenocarcinoma MCF-7, acute lymphocytic leukemia CCRF-CEM, and its doxorubicin-resistant variant CEM/ADR5000 and prostate cancer PC-3 cell lines. Selected derivatives have also been tested against the urinary bladder T24 and metastatic melanoma WM266-4 cancer cell lines. Two nitro substituted acridones, bearing a basic side chain as well, were endowed with a remarkable profile against the majority of the cell lines tested, with IC50 values in the low micromolar range. Both compounds cause accumulation at G0/G1 phase, induce apoptosis, and act as potent autophagy inhibitors in PC-3 cells, suggesting their further evaluation in various pathophysiological environments, conditions, and regimens. © 2020 The Authors
- Published
- 2020
24. Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins
- Author
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Anfosso, L, Efferth, T, Albini, A, and Pfeffer, U
- Published
- 2006
- Full Text
- View/download PDF
25. Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis ( N-phenyl) hydroxamic acid
- Author
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Majumder, S., Dutta, P., Mukherjee, P., Datta, E.R., Efferth, T., Bhattacharya, S., and Choudhuri, S.K.
- Published
- 2006
- Full Text
- View/download PDF
26. Multiple mechanistic anti-inflammatory activity of STW5-II on mouse intestinal organoids
- Author
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Elbadawi, M, additional, MAmmar, R, additional, Aziz-Kalbhenn, H, additional, Rabini, S, additional, and Efferth, T, additional
- Published
- 2020
- Full Text
- View/download PDF
27. Artesunate reduces cell growth and induces ferroptosis in therapy-resistant renal cell carcinoma cells
- Author
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Juengel, E., primary, Markowitsch, S., additional, Schupp, P., additional, Schunke, J., additional, Efferth, T., additional, Mager, R., additional, and Haferkamp, A., additional
- Published
- 2019
- Full Text
- View/download PDF
28. Apoptosis and resistance to daunorubicin in human leukemic cells
- Author
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Efferth, T, Fabry, U, and Osieka, R
- Published
- 1997
- Full Text
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29. O22 - Metastasis of cisplatin-resistant bladder cancer cells is impaired by artesunate through inhibition of integrin subtypes
- Author
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Vakhrusheva, O., Zhao, F., Markowitsch, S.D., Slade, K.S., Mager, R., Cinatl Jr., J., Michaelis, M., Efferth, T., Haferkamp, A., and Jüngel, E.
- Published
- 2022
- Full Text
- View/download PDF
30. The emergence of drug resistance to targeted cancer therapies: Clinical evidence
- Author
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Sarmento-Ribeiro, A.B. Scorilas, A. Gonçalves, A.C. Efferth, T. Trougakos, I.P.
- Abstract
For many decades classical anti-tumor therapies included chemotherapy, radiation and surgery; however, in the last two decades, following the identification of the genomic drivers and main hallmarks of cancer, the introduction of therapies that target specific tumor-promoting oncogenic or non-oncogenic pathways, has revolutionized cancer therapeutics. Despite the significant progress in cancer therapy, clinical oncologists are often facing the primary impediment of anticancer drug resistance, as many cancer patients display either intrinsic chemoresistance from the very beginning of the therapy or after initial responses and upon repeated drug treatment cycles, acquired drug resistance develops and thus relapse emerges, resulting in increased mortality. Our attempts to understand the molecular basis underlying these drug resistance phenotypes in pre-clinical models and patient specimens revealed the extreme plasticity and adaptive pathways employed by tumor cells, being under sustained stress and extensive genomic/proteomic instability due to the applied therapeutic regimens. Subsequent efforts have yielded more effective inhibitors and combinatorial approaches (e.g. the use of specific pharmacologic inhibitors with immunotherapy) that exhibit synergistic effects against tumor cells, hence enhancing therapeutic indices. Furthermore, new advanced methodologies that allow for the early detection of genetic/epigenetic alterations that lead to drug chemoresistance and prospective validation of biomarkers which identify patients that will benefit from certain drug classes, have started to improve the clinical outcome. This review discusses emerging principles of drug resistance to cancer therapies targeting a wide array of oncogenic kinases, along with hedgehog pathway and the proteasome and apoptotic inducers, as well as epigenetic and metabolic modulators. We further discuss mechanisms of resistance to monoclonal antibodies, immunomodulators and immune checkpoint inhibitors, potential biomarkers of drug response/drug resistance, along with possible new therapeutic avenues for the clinicians to combat devastating drug resistant malignancies. It is foreseen that these topics will be major areas of focused multidisciplinary translational research in the years to come. © 2019
- Published
- 2019
31. Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells
- Author
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Efferth, T., Fabry, U., Glatte, P., and Osieka, R.
- Published
- 1995
- Full Text
- View/download PDF
32. Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines
- Author
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Efferth, T., Löhrke, H., and Volm, M.
- Published
- 1990
- Full Text
- View/download PDF
33. Testing for tumor drug resistance in the age of molecular medicine. A contribution to the Debate Round-Table on phenotypic and genotypic analyses of multidrug resistance (MDR) in clinical hospital practice
- Author
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Efferth, T
- Published
- 1999
- Full Text
- View/download PDF
34. Analysen zur Integration von Naturstoffen aus der traditionellen chinesischen Medizin in die Behandlung vom therapieresistenten Nierenzellkarzinomen
- Author
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Markowitsch, S, Erb, H, Efferth, T, Haferkamp, A, and Jüngel, E
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Neue zielgerichtete Therapien haben die Behandlung des fortgeschrittenen Nierenzellkarzinoms (NZK) verbessert. Dennoch bleiben sie auf Grund von Resistenzen zeitlich limitiert. Substanzen aus der traditionellen chinesischen Medizin (TCM) könnten hier neue Therapieoptionen darstellen.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 59. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V. - Urologie im Südwesten: Innovation aus Tradition
- Published
- 2018
- Full Text
- View/download PDF
35. Molecular bases of the poor response of liver cancer to chemotherapy
- Author
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Marin, JJG, Briz, O, Herraez, E, Lozano, E, Asensio, M, Di Giacomo, S, Romero, MR, Osorio-Padilla, LM, Santos-Llamas, AI, Serrano, MA, Armengol, C, Efferth, T, and Macias, RIR
- Subjects
Cholangiocarcinoma ,Hepatoblastoma ,Targeted therapies ,Hepatocellular carcinoma ,Multidrug resistance - Abstract
A characteristic shared by most frequent types of primary liver cancer, i.e., hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) in adults, and in a lesser extent hepatoblastoma (HB) mainly in children, is their high refractoriness to chemotherapy. This is the result of synergic interactions among complex and diverse mechanisms of chemoresistance (MOC) in which more than 100 genes are involved. Pharmacological treatment, although it can be initially effective, frequently stimulates the expression of MOC genes, which results in the relapse of the tumor, usually with a more aggressive and less chemosensitive phenotype. Identification of the MOC genetic signature accounting for the "resistome" present at each moment of tumor life would prevent the administration of chemotherapeutic regimens without chance of success but still with noxious side effects for the patient. Moreover, a better description of cancer cells strength is required to develop novel strategies based on pharmacological, cellular or gene therapy to overcome liver cancer chemoresistance. (C) 2018 Elsevier Masson SAS. All rights reserved.
- Published
- 2018
36. Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient
- Author
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Efferth, T., Fabry, U., Glatte, P., and Osieka, R.
- Published
- 1995
- Full Text
- View/download PDF
37. P13 - Artesunate inhibits the progressive growth behavior of docetaxel-resistant prostate cancer cells
- Author
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Jüngel, E., Vakhrusheva, O., Erb, H.H.H., Braeunig, V., Markowitsch, S.D., Schupp, P., Slade, K.S., Thomas, A., Tsaur, I., Puhr, M., Culig, Z., Cinatl Jr., J., Michaelis, M., Efferth, T., and Haferkamp, A.
- Published
- 2021
- Full Text
- View/download PDF
38. The application of TCM to the treatment of psychiatry diseases: in vitro anti-oxidation and anti-inflammatory effect of Free and Easy Wanderer
- Author
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Hong, C., primary and Efferth, T., additional
- Published
- 2017
- Full Text
- View/download PDF
39. Structure determination and preliminary cytotoxicity researches of the compounds isolated from Rumex acetosella L. on leukemia cells
- Author
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Ozenver, N, additional, Saeed, M, additional, Kauhl, U, additional, Guvenalp, Z, additional, Demirezer Lutfiye, O, additional, Opatz, T, additional, and Efferth, T, additional
- Published
- 2017
- Full Text
- View/download PDF
40. Aloe-emodin's cytotoxicity against CCRF-CEM cells: NF-κB as a major player induces apoptosis
- Author
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Ozenver, N, additional, Saeed, M, additional, Demirezer Lutfiye, O, additional, and Efferth, T, additional
- Published
- 2017
- Full Text
- View/download PDF
41. Cytotoxicity of aloe-emodin towards several drug sensitive cells and their resistant counterparts
- Author
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Ozenver, N, additional, Saeed, M, additional, Demirezer Lutfiye, O, additional, and Efferth, T, additional
- Published
- 2017
- Full Text
- View/download PDF
42. Natural Products for Cancer Therapy – Is Economic Success Reachable?
- Author
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Shan L and Efferth T
- Subjects
medicine.medical_specialty ,business.industry ,In silico ,Cancer therapy ,Alternative medicine ,medicine ,Bioinformatics ,business ,Natural (archaeology) ,Antibiotic Drugs - Published
- 2016
43. Cytotoxicity Of Main Anthraquinone Aglycons Towards Drug Sensitive And Multi Drug Resistant T Leukaemia Cancer Cells
- Author
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Ozenver, N., Saeed, M., Demirezer, L. O., and Efferth, T.
- Abstract
Öz bulunamadı.
- Published
- 2016
44. Chrysophanol- And Nepodin-8-O-Beta-D-Glucopyranoside From Rumex Acetosella, The Cytotoxicity Towards Drug Sensitive And Multi- Drug Resistant T Leukaemia Cancer Cells
- Author
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Ozenver, N., Saeed, M., Guvenalp, Z., Demirezer, L. O., and Efferth, T.
- Abstract
Öz bulunamadı.
- Published
- 2016
45. O06 - Artesunate reduces cell growth and induces ferroptosis in therapy-resistant renal cell carcinoma cells
- Author
-
Juengel, E., Markowitsch, S., Schupp, P., Schunke, J., Efferth, T., Mager, R., and Haferkamp, A.
- Published
- 2019
- Full Text
- View/download PDF
46. Resistenzüberwindung bei Tumoren
- Author
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Volm M and Efferth T
- Subjects
Text mining ,Resistance (ecology) ,business.industry ,Chemistry ,General Medicine ,Computational biology ,business - Published
- 2008
47. Chemical characterisation and cytotoxicity evaluation of Convolvulus pluricaulis Sieb. ex Spreng. (Convolvulaceae) extracts towards sensitive and multidrug-resistant cancer cells
- Author
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Tacchini, M, additional, Paganetto, G, additional, Efferth, T, additional, Sacchetti, G, additional, and Guerrini, A, additional
- Published
- 2016
- Full Text
- View/download PDF
48. Cytotoxicity of main anthraquinone aglycons towards drug sensitive and multi drug resistant T leukaemia cancer cells
- Author
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Ozenver, N, additional, Saeed, M, additional, Demirezer, LO, additional, and Efferth, T, additional
- Published
- 2016
- Full Text
- View/download PDF
49. Chrysophanol- and nepodin-8-O-β-D-glucopyranoside from Rumex acetosella, the cytotoxicity towards drug sensitive and multi- drug resistant T leukaemia cancer cells
- Author
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Ozenver, N, additional, Saeed, M, additional, Guvenalp, Z, additional, Demirezer, LO, additional, and Efferth, T, additional
- Published
- 2016
- Full Text
- View/download PDF
50. Ziziphora tenuior L. essential oil from Dana Biosphere Reserve (Southern Jordan); Chemical characterization and assessment of biological activities
- Author
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Abu-Darwish, M.S., primary, Cabral, C., additional, Gonçalves, M.J., additional, Cavaleiro, C., additional, Cruz, M.T., additional, Paoli, M., additional, Tomi, F., additional, Efferth, T., additional, and Salgueiro, L., additional
- Published
- 2016
- Full Text
- View/download PDF
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