Search

Your search keyword '"Egeberg, R"' showing total 133 results
Start Over Author "Egeberg, R"
133 results on '"Egeberg, R"'

1. Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

Author

Crowe, F L, Key, T J, Appleby, P N, Overvad, K, Schmidt, E B, Egeberg, R, Tjønneland, A, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Trichopoulou, A, Ouranos, V, Valanou, E, Masala, G, Sieri, S, Panico, S, Tumino, R, Matullo, G, Bueno-de-Mesquita, H B, Boer, J M A, Beulens, J W J, van der Schouw, Y T, Quirós, J R, Buckland, G, Sánchez, M-J, Dorronsoro, M, Huerta, J M, Moreno-Iribas, C, Hedblad, B, Jansson, J H, Wennberg, P, Khaw, K-T, Wareham, N, Ferrari, P, Illner, A-K, Chuang, S-C, Norat, T, Danesh, J, and Riboli, E

Published
2012
Full Text
View/download PDF

2. Specific food group combinations explaining the variation in intakes of nutrients and other important food components in the European Prospective Investigation into Cancer and Nutrition: an application of the reduced rank regression method

Author

Kröger, J, Ferrari, P, Jenab, M, Bamia, C, Touvier, M, Bueno-de-Mesquita, H B, Fahey, M T, Benetou, V, Schulz, M, Wirfält, E, Boeing, H, Hoffmann, K, Schulze, M B, Orfanos, P, Oikonomou, E, Huybrechts, I, Rohrmann, S, Pischon, T, Manjer, J, Agren, A, Navarro, C, Jakszyn, P, Boutron-Ruault, M C, Niravong, M, Khaw, K T, Crowe, F, Ocké, M C, van der Schouw, Y T, Mattiello, A, Bellegotti, M, Engeset, D, Hjartåker, A, Egeberg, R, Overvad, K, Riboli, E, Bingham, S, and Slimani, N

Published
2009

5. Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study

Author

Benedinelli, B, Palli, D, Masala, G, Sharp, Sj, Schulz, Mb, Guevara, M, van der AD, Sera, F, Amiano, P, Balkau, B, Barricarte, A, Boeing, H, Crowe, Fl, Dahm, Cc, Dalmeijer, G, de Lauzon Guillain, B, Egeberg, R, Fagherazzi, G, Franks, Pw, Krogh, V, Huerta, Jm, Jakszyn, P, Khaw, Kt, Li, K, Mattiello, A, Nilsson, Pm, Overvad, K, Ricceri, Fulvio, Rolandsson, O, Sánchez, Mj, Slimani, N, Sluijs, I, Spijkerman, Am, Teucher, B, Tjonneland, A, Tumino, R, van den Berg SW, Forouhi, Ng, Langeberg, C, Feskens, Ej, Riboli, E, Wareham, Nj, and Interact, Consortium

Subjects
Adult, Male, Risk, Meat, Nutrition and Disease, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Cohort Studies, Young Adult, Voeding en Ziekte, Diabetes mellitus, Internal Medicine, Humans, Medicine, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Sex Characteristics, business.industry, Incidence, Case-control study, Middle Aged, medicine.disease, Diet, European Prospective Investigation into Cancer and Nutrition, Europe, Meat Products, Cross-Sectional Studies, Case-cohort study, Diabetes Mellitus, Type 2, Case-Control Studies, Red meat, Female, business, Iron, Dietary, Follow-Up Studies, Demography, Cohort study
Abstract

Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

Published
2012
Full Text
View/download PDF

6. Consumption of meat and fish and risk oflung cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author

Linseisen J, Rohrmann S, Bueno de Mesquita B, Büchner FL, Boshuizen HC, Agudo A, Gram IT, Dahm CC, Overvad K, Egeberg R, Tjønneland A, Boeing H, Steffen A, Kaaks R, Lukanova A, Berrino F, Palli D, Tumino R, Ardanaz E, Dorronsoro M, Huerta JM, Rodríguez L, Sánchez MJ, Rasmuson T, Hallmans G, Manjer J, Wirfält E, Engeset D, Skeie G, Katsoulis M, Oikonomou E, Trichopoulou A, Peeters PH, Khaw KT, Wareham N, Allen N, Key T, Brennan P, Romieu I, Slimani N, Vergnaud AC, Xun WW, Vineis P, Riboli E., PANICO, SALVATORE, Linseisen, J, Rohrmann, S, Bueno de Mesquita, B, Büchner, Fl, Boshuizen, Hc, Agudo, A, Gram, It, Dahm, Cc, Overvad, K, Egeberg, R, Tjønneland, A, Boeing, H, Steffen, A, Kaaks, R, Lukanova, A, Berrino, F, Palli, D, Panico, Salvatore, Tumino, R, Ardanaz, E, Dorronsoro, M, Huerta, Jm, Rodríguez, L, Sánchez, Mj, Rasmuson, T, Hallmans, G, Manjer, J, Wirfält, E, Engeset, D, Skeie, G, Katsoulis, M, Oikonomou, E, Trichopoulou, A, Peeters, Ph, Khaw, Kt, Wareham, N, Allen, N, Key, T, Brennan, P, Romieu, I, Slimani, N, Vergnaud, Ac, Xun, Ww, Vineis, P, and Riboli, E.

Published
2011

7. Specific food group combinations explaining the variation in intakes of nutrients and other important food components in the european prospective investigation into cancer and nutrition: An application of the reduced rank regression method

Author

Kröger, J. Ferrari, P. Jenab, M. Bamia, C. Touvier, M. Bueno-De-Mesquita, H.B. Fahey, M.T. Benetou, V. Schulz, M. Wirfält, E. Boeing, H. Hoffmann, K. Schulze, M.B. Orfanos, P. Oikonomou, E. Huybrechts, I. Rohrmann, S. Pischon, T. Manjer, J. Agren, A. Navarro, C. Jakszyn, P. Boutron-Ruault, M.C. Niravong, M. Khaw, K.T. Crowe, F. Ocké, M.C. Van Der Schouw, Y.T. Mattiello, A. Bellegotti, M. Engeset, D. Hjartåker, A. Egeberg, R. Overvad, K. Riboli, E. Bingham, S. Slimani, N.

Abstract

Objective:To identify combinations of food groups that explain as much variation in absolute intakes of 23 key nutrients and food components as possible within the country-specific populations of the European Prospective Investigation into Cancer and Nutrition (EPIC).Subjects/Methods:The analysis covered single 24-h dietary recalls (24-HDR) from 36 034 subjects (13 025 men and 23 009 women), aged 35–74 years, from all 10 countries participating in the EPIC study. In a set of 39 food groups, reduced rank regression (RRR) was used to identify those combinations (RRR factors) that explain the largest proportion of variation in intake of 23 key nutrients and food components, namely, proteins, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, cholesterol, sugars (sum of mono- and disaccharides), starch, fibre, alcohol, calcium, iron, potassium, phosphorus, magnesium, vitamin D, β-carotene, retinol and vitamins E, B1, B2, B6, B12 and C (RRR responses). Analyses were performed at the country level and for all countries combined. Results: In the country-specific analyses, the first RRR factor explained a considerable proportion of the total nutrient intake variation in all 10 countries (27.4–37.1%). The subsequent RRR factors were much less important in explaining the variation (⩽6%). Strong similarities were observed for the first country-specific RRR factor between the individual countries, largely characterized by consumption of bread, vegetable oils, red meat, milk, cheese, potatoes, margarine and processed meat. The highest explained variation was seen for protein, potassium, phosphorus and magnesium (50–70%), whereas sugars, β-carotene, retinol and alcohol were only marginally explained (⩽5%). The explained proportion of the other nutrients ranged between these extremes.Conclusions:A combination of food groups was identified that explained a considerable proportion of the nutrient intake variation in 24-HDRs in every country-specific EPIC population in a similar manner. This indicates that, despite the large variability in food and nutrient intakes reported in the EPIC, the variance of intake of important nutrients is explained, to a large extent, by similar food group combinations across countries. © 2009 Macmillan Publishers Limited. All rights reserved.

Published
2009

9. Association between dietary meat consumption and incident type 2 diabetes : the EPIC-InterAct study

Author

Bendinelli, B., Palli, D., Masala, G., Sharp, S. J., Schulze, M. B., Guevara, M., van der A, D. L., Sera, F., Amiano, P., Balkau, B., Barricarte, A., Boeing, H., Crowe, F. L., Dahm, C. C., Dalmeijer, G., de Lauzon-Guillain, B., Egeberg, R., Fagherazzi, G., Franks, Paul W., Krogh, V., Huerta, J. M., Jakszyn, P., Khaw, K. T., Li, K., Mattiello, A., Nilsson, P. M., Overvad, K., Ricceri, F., Rodríguez-Suárez, L., Rolandsson, Olov, Sánchez, M. J., Slimani, N., Sluijs, I., Spijkerman, A. M. W., Teucher, B., Tjonneland, A., Tumino, R., van den Berg, S. W., Forouhi, N. G., Langenberg, C., Feskens, E. J. M., Riboli, E., Wareham, N. J., Bendinelli, B., Palli, D., Masala, G., Sharp, S. J., Schulze, M. B., Guevara, M., van der A, D. L., Sera, F., Amiano, P., Balkau, B., Barricarte, A., Boeing, H., Crowe, F. L., Dahm, C. C., Dalmeijer, G., de Lauzon-Guillain, B., Egeberg, R., Fagherazzi, G., Franks, Paul W., Krogh, V., Huerta, J. M., Jakszyn, P., Khaw, K. T., Li, K., Mattiello, A., Nilsson, P. M., Overvad, K., Ricceri, F., Rodríguez-Suárez, L., Rolandsson, Olov, Sánchez, M. J., Slimani, N., Sluijs, I., Spijkerman, A. M. W., Teucher, B., Tjonneland, A., Tumino, R., van den Berg, S. W., Forouhi, N. G., Langenberg, C., Feskens, E. J. M., Riboli, E., and Wareham, N. J.

Abstract

Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

Published
2013
Full Text
View/download PDF

10. Dietary fibre intake and ischaemic heart disease mortality : the European Prospective Investigation into Cancer and Nutrition-Heart study

Author

Crowe, F. L., Key, T. J., Appleby, P. N., Overvad, K., Schmidt, E. B., Egeberg, R., Tjonneland, A., Kaaks, R., Teucher, B., Boeing, H., Weikert, C., Trichopoulou, A., Ouranos, V., Valanou, E., Masala, G., Sieri, S., Panico, S., Tumino, R., Matullo, G., Bueno-de-Mesquita, H. B., Boer, J. M. A., Beulens, J. W. J., van der Schouw, Y. T., Quiros, J. R., Buckland, G., Sanchez, M-J, Dorronsoro, M., Huerta, J. M., Moreno-Iribas, C., Hedblad, B., Jansson, J. H., Wennberg, Patrik, Khaw, K-T, Wareham, N., Ferrari, P., Illner, A-K, Chuang, S-C, Norat, T., Danesh, J., Riboli, E., Crowe, F. L., Key, T. J., Appleby, P. N., Overvad, K., Schmidt, E. B., Egeberg, R., Tjonneland, A., Kaaks, R., Teucher, B., Boeing, H., Weikert, C., Trichopoulou, A., Ouranos, V., Valanou, E., Masala, G., Sieri, S., Panico, S., Tumino, R., Matullo, G., Bueno-de-Mesquita, H. B., Boer, J. M. A., Beulens, J. W. J., van der Schouw, Y. T., Quiros, J. R., Buckland, G., Sanchez, M-J, Dorronsoro, M., Huerta, J. M., Moreno-Iribas, C., Hedblad, B., Jansson, J. H., Wennberg, Patrik, Khaw, K-T, Wareham, N., Ferrari, P., Illner, A-K, Chuang, S-C, Norat, T., Danesh, J., and Riboli, E.

Abstract

BACKGROUND/OBJECTIVES: Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study. SUBJECTS/METHODS: Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall. RESULTS: After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P = 0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07). CONCLUSION: A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.

Published
2012
Full Text
View/download PDF

11. Journal of Porous Materials

Author

Egeberg, R. C., Veje, E., Silva, A. Ferreira da, Pepe, Iuri Muniz, and Alves, A. Santos

Subjects
porous silicon, photoacoustic spectroscopy, energy band
Abstract

Texto completo: acesso restrito. p.173-176 Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-17T10:41:00Z No. of bitstreams: 1 Veje.pdf: 36072 bytes, checksum: fc6b0bd61589b0e9f2b55647c613efad (MD5) Made available in DSpace on 2013-01-17T10:41:00Z (GMT). No. of bitstreams: 1 Veje.pdf: 36072 bytes, checksum: fc6b0bd61589b0e9f2b55647c613efad (MD5) Previous issue date: 2000 Porous silicon has been studied with photoluminescence, photoluminescence excitation, and photoacoustic spectroscopy. From the luminescence data, an energy-level diagram related to the luminescence is constructed. The diagram is confirmed in detail by the photoacoustic spectra. The results are discussed with the conclusion that they are in good agreement with the surface-band oxyhydride-like emitter, which recently has been established as the source for the photoluminescence from porous silicon.

Published
2000
Full Text
View/download PDF

12. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, E.J., Travier, N., Lujan-Barroso, L., Clavel-Chapelon, F., Boutron-Ruault, M.C., Morois, S., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Quiros, J.R., Sanchez-Cantalejo, E., Navarro, C, Gurrea, A.B., Dorronsoro, M., Khaw, K.T., Allen, N.E., Key, T.J., Bueno-De-Mesquita, H.B., Ros, M.M., Numans, M.E., Peeters, P.H.M., Trichopoulou, A., Naska, A., Dilis, V., Teucher, B., Kaaks, R., Boeing, H., Schutze, M., Regner, S., Lindkvist, B., Johansson, I., Hallmans, G., Overvad, K., Egeberg, R., Tjonneland, A., Lund, E., Weiderpass, E., Braaten, T., Romieu, I., Ferrari, P., Jenab, M., Stenling, R., Aune, D., Norat, T., Riboli, E., Gonzalez, C.A., Duell, E.J., Travier, N., Lujan-Barroso, L., Clavel-Chapelon, F., Boutron-Ruault, M.C., Morois, S., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Quiros, J.R., Sanchez-Cantalejo, E., Navarro, C, Gurrea, A.B., Dorronsoro, M., Khaw, K.T., Allen, N.E., Key, T.J., Bueno-De-Mesquita, H.B., Ros, M.M., Numans, M.E., Peeters, P.H.M., Trichopoulou, A., Naska, A., Dilis, V., Teucher, B., Kaaks, R., Boeing, H., Schutze, M., Regner, S., Lindkvist, B., Johansson, I., Hallmans, G., Overvad, K., Egeberg, R., Tjonneland, A., Lund, E., Weiderpass, E., Braaten, T., Romieu, I., Ferrari, P., Jenab, M., Stenling, R., Aune, D., Norat, T., Riboli, E., and Gonzalez, C.A.

Abstract

Item does not contain fulltext, BACKGROUND: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. OBJECTIVE: We evaluated the association between alcohol consumption and GC risk. DESIGN: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. RESULTS: Heavy (compared with very light) alcohol consumption (>/=60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (<60 g/d) were not. When we analyzed GC risk by type of alcoholic beverage, there was a positive association for beer (>/=30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed. CONCLUSION: Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort.

Published
2011

13. Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study

Author

Egeberg, R, Olsen, Anja Viendahl, Loft, S, Christensen, J, Johnsen, N F, Overvad, K, Tjønneland, A, Egeberg, R, Olsen, Anja Viendahl, Loft, S, Christensen, J, Johnsen, N F, Overvad, K, and Tjønneland, A

Abstract

Udgivelsesdato: 2010-Aug-24, BACKGROUND: Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS: The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal cancer that developed during 10.6 years (median) of follow-up among 26 630 men and 29 189 women taking part in the Diet, Cancer and Health cohort. Incidence rate ratios (IRRs) of colon and rectal cancer related to total or individual WG product intake were calculated using Cox regression. RESULTS: Higher WG product intake was associated with lower risk of colon cancer and rectal cancer in men. The adjusted IRR (95% CI) was 0.85 (0.77-0.94) for colon cancer and 0.90 (0.80-1.01) for rectal cancer per daily 50 g increment in intake. For colon cancer the association was confined to intake of WG bread in particular. No consistent associations between total or individual WG product consumption and colon or rectal cancer risk were observed in women. CONCLUSION: The findings suggest that higher total WG product intake is associated with a lower risk of colon and perhaps rectal cancer in men, but not in women.

Published
2010

18. Role of Steps inN2Activation on Ru(0001)

Author

Dahl, S., primary, Logadottir, A., additional, Egeberg, R. C., additional, Larsen, J. H., additional, Chorkendorff, I., additional, Törnqvist, E., additional, and Nørskov, J. K., additional

Published
1999
Full Text
View/download PDF

20. Social inequality and incidence of and survival from cancers of the colon and rectum in a population-based study in Denmark, 1994-2003.

Author

Egeberg R, Halkjaer J, Rottmann N, Hansen L, and Holten I

Abstract

We investigated the effects of socioeconomic indicators, demographic indicators and health-related indicators on the incidence of and survival from colon cancer and rectal cancer diagnosed in 1994-2003 with follow-up through 2006 in Denmark using information from nationwide registers. The analyses were based on data on 9958 patients with colon cancer and 7411 patients with rectal cancer in a cohort of 3.22 million people born between 1925 and 1973 and aged >or=30 years. Higher incidences of colon and rectal cancers were associated with greater social disadvantage, predominantly amongst men, in regard to cohabiting status, housing tenure, dwelling size and affiliation to the work market. Comorbidity was associated with a higher incidence of colon cancer in both sexes. Short- and long-term relative survival from both colon and rectal cancers decreased with poorer education, disposable income, affiliation to the work market, housing tenure, dwelling size and cohabiting status. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

25. CLINICAL EXPERIENCE WITH NITROGEN MUSTARD THERAPY

Author

GOLDMAN, R., EGEBERG, R. O., WARE, E. R., EVANS, E. R., and FISHKIN, B. G.

Abstract

RECENT reports of results obtained with the use of nitrogen mustard derivatives have aroused much speculation regarding the efficacy of chemotherapy in certain malignant neoplastic diseases. The Veterans Administration Hospital, West Los Angeles, Calif., has been designated as a center for the treatment of tumors. This provided a relatively large number of patients who had leukemias and lymphomas, and it was decided to evaluate the effects of nitrogen mustard therapy on a suitable group. METHOD AND RESULTS METHOD. —The routine study included a search for enlarged lymph nodes, examination of the liver and spleen, complete blood count, sternal puncture, roentgenologic study of the chest and biopsy. The patient was then presented to the members of a Tumor Board, who selected the type of therapy to be used in each instance. In those patients for whom the nitrogen mustard treatment was recommended, the bis form of the drug was administered intravenously,

Published
1948
Full Text
View/download PDF

26. C. immitis--vicissitudes of its environment

Author

Egeberg, R. O., Elconin, A., and Egeberg, M. C.

Subjects
Coccidioidomycosis, Coccidioides, Arizona, Temperature, Humans, Seasons, In Vitro Techniques, California, Soil Microbiology, Research Article
Published
1966

27. General Douglas Macarthur

Author

Egeberg, R. O.

Subjects
Military Personnel, Famous Persons, History, 20th Century, Research Article
Published
1967

28. Consumption of meat and fish and risk of lung cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author

Linseisen, J, Rohrmann, S, Bueno-de-Mesquita, B, Büchner, F L, Boshuizen, H C, Agudo, A, Gram, I T, Dahm, C C, Overvad, K, Egeberg, R, Tjønneland, A, Boeing, H, Steffen, A, Kaaks, R, Lukanova, A, Berrino, F, Palli, D, Panico, S, Tumino, R, Ardanaz, E, Dorronsoro, M, Huerta, J M, Rodríguez, L, Sánchez, M J, Rasmuson, T, Hallmans, G, Manjer, J, Wirfält, E, Engeset, D, Skeie, G, Katsoulis, M, Oikonomou, E, Trichopoulou, A, Peeters, P H M, Khaw, K T, Wareham, N, Allen, N, Key, T, Brennan, P, Romieu, I, Slimani, N, Vergnaud, A C, Xun, W W, Vineis, P, and Riboli, E

Subjects
3. Good health

37. Consider new technology to produce renewable diesel.

Author

Michaelsen, N. Høygaarg, Egeberg, R., and Nyström, S.

Subjects
*PETROLEUM technology, *HYDROTREATING catalysts, *PETROLEUM refineries, *MINERAL oils, *DIESEL fuels, *DESULFURIZATION in petroleum refining
Abstract

The article focuses on the use of the new hydrotreating technology invented by the Preem AB's Gothenburg refinery and a technology/catalyst licensor. It states that the new technology enables the co-processing of light gasoil (GO) and raw tall diesel (RTD) which produces green diesel. It also notes that the technology maintains high hydrodesulfurization (HDS) activity and co-processes organic material and mineral oil.

Published
2009

39. Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition

Author

Pietro Ferrari, Dagrun Engeset, Timothy J. Key, Kuanrong Li, Anne Tjønneland, Kim Overvad, José María Huerta, H. Bas Bueno-de-Mesquita, Christine L. Parr, Guri Skeie, Pilar Amiano, Kay-Tee Khaw, Teresa Norat, Göran Hallmans, Anne C. Vergnaud, Isabelle Romieux, Fulvio Ricceri, M. Luisa Redondo, Dimitirios Trichopoulos, Rosario Tumino, Veronika Fedirko, Françoise Clavel-Chapelon, Elio Riboli, Androniki Naska, Rikke Egeberg, Nicholas J. Wareham, Marianne Uhre Jakobsen, Emily Sonestedt, Heiner Boeing, Aurelio Barricarte, Salvatore Panico, Max Leenders, Manuela M. Bergmann, Laura Nailler, Isabel Drake, Paula Jakszyn, Marie-Christine Boutron-Ruault, Domenico Palli, Sabine Rohrmann, Vittorio Krogh, Antonia Trichopoulou, María José Sánchez, Jakob Linseisen, Petra H.M. Peeters, Ingegerd Johansson, Francesca L. Crowe, Rudolf Kaaks, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, University of Zurich, Rohrmann, Sabine, [Rohrmann,S] Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland. [Rohrmann,S., Li,K, Kaaks,R, Linseisen,J] Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany. [Overvad,K, Jakobsen,MU] Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.[Bueno-de-Mesquita, HB, Leenders,M] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. [Egeberg,R, Tjønneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Nailler,L, Boutron-Ruault,MC, Clavel-Chapelon,F] Inserm, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif, France. [Nailler,L, Clavel-Chapelon,F] Paris South University, UMRS, Villejuif, France. [Krogh,V] Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. [Palli,D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. [Panico,S] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civile - M.P.Arezzo' Hospital, Ragusa, Italy. [Ricceri,F] HuGeF - Human Genetics Foundation - Torino, Torino, Italy. [Bergmann,MM, Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany. [Khaw,KT] Department of Public Health and Primary Care, University of Cambridge, Cambridge UK. [Wareham,NJ] Medical Research Council (MRC) Epidemiology Unit, Cambridge UK. [Crowe,FL, Key,TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. [Naska,A, Trichopoulou,A] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Trichopoulou,A, Trichopoulos,D] Hellenic Health Foundation, Athens, Greece. [Trichopoulos,D] Department of Epidemiology, Harvard School of Public Health, Boston MA, USA.Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Peeters,PHM] Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands. [Peeters,PHM, Norat,T, Vergnaud,AC, Riboli,E] School of Public Health, Imperial College, London, UK. [Engeset,D, Skeie,G] Department of Community Medicine, University of Tromsø, Tromsø, Norway. [Parr,CL] Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway. [Jakszyn,P] Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Barcelona, Spain. [Sánchez,MJ, Huerta,JM] Andalusian School of Public Health, Granada, Spain. [Sánchez,MJ, Barricarte,A, Amiano,P] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Redondo,ML] Public Health Directorate Asturias, Oviedo, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Amiano,P] Public Health Division of Gipuzkoa, BIODonostia Research Institute, Department of Health of the Regional Government of the Basque Country, San Sebastian, Spain. [Drake,I, Sonestedt,E] Department of Clinical Sciences, Lund University, Malmö, Sweden. [Hallmans,G] Department of Public Health and Clinical Medicine, Nutrition Research, Umeå University, Umeå, Sweden. [Johansson,I] Department of Odontology, Cariology, Umeå University, Umeå, Sweden. [Fedirko,V, Romieux,I, Ferrari,P] International Agency for Research on Cancer (IARC), Lyon, France. [Linseisen,J] Institute of Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany., Europe Against Cancer Program of the European Commission (SANCO), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, ISCIII RCESP exp. C03/09, Spain, Cancer Research UK, Medical Research Council, United Kingdom, Stroke Association, United Kingdom, British Heart Foundation, Department of Health, United Kingdom, Food Standards Agency, United Kingdom, Wellcome Trust, United Kingdom, the Hellenic Health Foundation and the Stavros Niarchos Foundation, Italian Association for Research on Cancer (AIRC), Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy, Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skåne, Sweden, Nordforsk the Norwegian Cancer Society, French League against Cancer (LNCC), National Institute for Health and Medical Research (INSERM), France, Mutuelle Générale de l’Education Nationale (MGEN), France, 3M Co, France, Gustave Roussy Institute (IGR), France, and General Councils of France, BMC, Ed., Division of Cancer Epidemiology and Prevention, Universität Zürich [Zürich] = University of Zurich (UZH)-Institute of Social and Preventive Medicine, Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Section of Epidemiology, Aarhus University [Aarhus], Department of Gastroenterology and Hepatology, University Medical Centre, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Department of Clinical and Experimental Medicine, University of Naples Federico II = Università degli studi di Napoli Federico II, Cancer Registry and Histopathology Unit, Civile - M.P.Arezzo Hospital, HuGeF - Human Genetics Foundation - Torino, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Epidemiology Unit, Medical Research Council, Cancer Epidemiology Unit, University of Oxford, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School [Athens], Hellenic Health Foundation, Harvard School of Public Health, Bureau of Epidemiologic Research, Academy of Athens, Julius Center, University Medical Center [Utrecht], School of Public Health, Imperial College London, Department of Community Medicine, University of Tromsø (UiT), Department of Biostatistics [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Andalusian School of Public Health [Granada], Consortium for Biomedical Research in Epidemiology and Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council, Public Health Directorate Asturias, Navarre Public Health Institute, Public Health Division of Gipuzkoa, BIODonostia Research Institute, Department of Clinical Sciences, Lund University [Lund], Department of Public Health and Clinical Medicine, Umeå University, Department of Odontology, Cariology, International Agency for Cancer Research (IACR), Institute of Epidemiology, Helmholtz Centre Munich, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli studi di Napoli Federico II, University of Oxford [Oxford], Rohrmann, S, Overvad, K, Bueno de Mesquita, Hb, Jakobsen, Mu, Egeberg, R, Tj?nneland, A, Nailler, L, Boutron Ruault, Mc, Clavel Chapelon, F, Krogh, V, Palli, D, Panico, Salvatore, Tumino, R, Ricceri, F, Bergmann, Mm, Boeing, H, Li, K, Kaaks, R, Khaw, Kt, Wareham, Nj, Crowe, Fl, Key, Tj, Naska, A, Trichopoulou, A, Trichopoulos, D, Leenders, M, Peeters, Ph, Engeset, D, Parr, Cl, Skeie, G, Jakszyn, P, S?nchez, Mj, Huerta, Jm, Redondo, Ml, Barricarte, A, Amiano, P, Drake, I, Sonestedt, E, Hallmans, G, Johansson, I, Fedirko, V, Romieux, I, Ferrari, P, Norat, T, Vergnaud, Ac, Riboli, E, and Linseisen, J.

Subjects
Male, 030309 nutrition & dietetics, Colorectal cancer, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings], Review, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], 2700 General Medicine, DISEASE, COLORECTAL-CANCER, VDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cohort Studies, Diet, Meat, Mortality, Cohort, Europe, Cardiovascular, Cancer, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Nutrition Surveys [Medical Subject Headings], 0302 clinical medicine, Neoplasms, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Medicine(all), RISK, CALIBRATION, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, cardiovascular, Diabetes, Hazard ratio, food and beverages, cohort, General Medicine, Diseases::Neoplasms [Medical Subject Headings], Middle Aged, Nutrition Surveys, Neoplasias, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Näringslära, Cardiovascular Diseases, Red meat, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Enfermedades cardiovasculares, Life Sciences & Biomedicine, Geographicals::Geographic Locations::Americas::North America::United States [Medical Subject Headings], CERTIFICATES, Research Article, Cohort study, Technology, Industry, Agriculture::Food and Beverages::Food::Meat [Medical Subject Headings], Adult, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Processed meat, Estudios de cohortes, Check Tags::Male [Medical Subject Headings], 610 Medicine & health, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811, VEGETARIANS, 03 medical and health sciences, Medicine, General & Internal, General & Internal Medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], medicine, cancer, Humans, ddc:610, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Aged, Science & Technology, business.industry, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Feeding Behavior, medicine.disease, mortality, Survival Analysis, United States, Surgery, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, RED MEAT, Check Tags::Female [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Commentary, 21-YEAR FOLLOW-UP, business, Body mass index, Demography
Abstract

Background Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods Included in the analysis were 448,568 men and women without prevalent cancer, stroke, or myocardial infarction, and with complete information on diet, smoking, physical activity and body mass index, who were between 35 and 69 years old at baseline. Cox proportional hazards regression was used to examine the association of meat consumption with all-cause and cause-specific mortality. Results As of June 2009, 26,344 deaths were observed. After multivariate adjustment, a high consumption of red meat was related to higher all-cause mortality (hazard ratio (HR) = 1.14, 95% confidence interval (CI) 1.01 to 1.28, 160+ versus 10 to 19.9 g/day), and the association was stronger for processed meat (HR = 1.44, 95% CI 1.24 to 1.66, 160+ versus 10 to 19.9 g/day). After correction for measurement error, higher all-cause mortality remained significant only for processed meat (HR = 1.18, 95% CI 1.11 to 1.25, per 50 g/d). We estimated that 3.3% (95% CI 1.5% to 5.0%) of deaths could be prevented if all participants had a processed meat consumption of less than 20 g/day. Significant associations with processed meat intake were observed for cardiovascular diseases, cancer, and 'other causes of death'. The consumption of poultry was not related to all-cause mortality. Conclusions The results of our analysis support a moderate positive association between processed meat consumption and mortality, in particular due to cardiovascular diseases, but also to cancer.

Published
2013
Full Text
View/download PDF

40. Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author

Françoise Clavel-Chapelon, Birigit Teucher, Björn Lindkvist, Tobias Pischon, Paolo Vineis, H. Bas Bueno-de-Mesquita, Philippos Orfanos, Magritt Brustad, Aurelio Barricarte, Petra H.M. Peeters, Laudina Rodríguez, Teresa Norat, Elio Riboli, Anne Tjønneland, Pietro Ferrari, Francesca L. Crowe, Guri Skeie, Marie-Christine Boutron-Ruault, Eric J. Duell, Dagrun Engeset, Ute Nöthlings, Weimin Ye, Rosario Tumino, Mazda Jenab, Pilar Amiano, Nicholas J. Wareham, Verena A. Grote, Kay-Tee Khaw, Salvatore Panico, Sabine Rohrmann, Antonia Trichopoulou, Ioulia Goufa, Esther Molina-Montes, Suzanne M. Jeurnink, Jakob Linseisen, Dorthe Johansen, Kim Overvad, Heather Ward, Valeria Pala, Rikke Egeberg, María José Tormo, Domenico Palli, Peter D. Siersema, Heiner Boeing, Malin Sund, Nadia Slimani, Vanessa Cottet, Rohrmann, S, Linseisen, J, N?thlings, U, Overvad, K, Egeberg, R, Tj?nneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Cottet, V, Pala, V, Tumino, R, Palli, D, Panico, Salvatore, Vineis, P, Boeing, H, Pischon, T, Grote, V, Teucher, B, Khaw, Kt, Wareham, Nj, Crowe, Fl, Goufa, I, Orfanos, P, Trichopoulou, A, Jeurnink, Sm, Siersema, Pd, Peeters, Ph, Brustad, M, Engeset, D, Skeie, G, Duell, Ej, Amiano, P, Barricarte, A, Molina Montes, E, Rodr?guez, L, Tormo, Mj, Sund, M, Ye, W, Lindkvist, B, Johansen, D, Ferrari, P, Jenab, M, Slimani, N, Ward, H, Riboli, E, Norat, T, Bueno de Mesquita, Hb, University of Zurich, and Rohrmann, Sabine

Subjects
Male, Oncology, Cancer Research, medicine.medical_specialty, Meat, Nutritional Status, Cohort, Epic, Fish, Pancreatic Cancer, 610 Medicine & health, Risk Assessment, Poultry, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pancreatic cancer, Internal medicine, Fish Products, medicine, Animals, Humans, 1306 Cancer Research, Prospective Studies, 030212 general & internal medicine, ddc:610, Prospective cohort study, Life Style, 2. Zero hunger, business.industry, Fishes, Feeding Behavior, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Middle Aged, medicine.disease, Diet, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Pancreatic Neoplasms, 030220 oncology & carcinogenesis, Relative risk, Red meat, Female, 2730 Oncology, business, Risk assessment, Cohort study
Abstract

Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI = 0.93-1.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI = 0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day = 1.72, 95% CI = 1.04-2.84); however, there was no association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI = 0.92-1.62). Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings.

Published
2016

41. Meat and heme iron intake and risk of squamous cell carcinoma of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Ulrika Ericson, Petra H.M. Peeters, J. Ramón Quirós, Domenico Palli, Alessio Naccarati, Peter D. Siersema, Ingegerd Johansson, María Dolores Chirlaque, Heiner Boeing, Francesca L. Crowe, H. B. Bueno-de-Mesquita, Manuela M. Bergmann, Isabelle Romieu, Anne-Claire Vergnaud, Pietro Ferrari, Signe Borgquist, Göran Hallmanns, Salvatore Panico, Despoina Oikonomidou, Vittorio Krogh, Pilar Amiano, Aurelio Barricarte Gurrea, Kim Overvad, Veronika Fedirko, Kay-Tee Khaw, Traci Mouw, Menelaos Pantzalis, Nicholas J. Wareham, Paula Jakszyn, Verena A. Grote, Teresa Norat, María José Sánchez, Rosario Tumino, Anne Tjønneland, Rikke Egeberg, Guri Skeie, Naomi E. Allen, Annika Steffen, Kuanrong Li, Antonia Trichopoulou, Steffen, A, Bergmann, Mm, S?nchez, Mj, Chirlaque, Md, Jakszyn, P, Amiano, P, Quir?s, Jr, Barricarte Gurrea, A, Ferrari, P, Romieu, I, Fedirko, V, Bueno de Mesquita, Hb, Siersema, Pd, Peeters, Ph, Khaw, Kt, Wareham, N, Allen, Ne, Crowe, Fl, Skeie, G, Hallmanns, G, Johansson, I, Borgquist, S, Ericson, U, Egeberg, R, Tj?nneland, A, Overvad, K, Grote, V, Li, K, Trichopoulou, A, Oikonomidou, D, Pantzalis, M, Tumino, R, Panico, Salvatore, Palli, D, Krogh, V, Naccarati, A, Mouw, T, Vergnaud, Ac, Norat, T, and Boeing, H.

Subjects
Male, Risk, medicine.medical_specialty, Pathology, Meat, Epidemiology, Heme iron, Heme, EPIC, Gastroenterology, Risk Assessment, Article, Cohort Studies, Internal medicine, medicine, Humans, Basal cell, Prospective Studies, Prospective cohort study, Laryngeal Neoplasms, Proportional Hazards Models, business.industry, Feeding Behavior, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Europe, stomatognathic diseases, Oncology, Carcinoma, Squamous Cell, Digestive tract, Female, Risk assessment, business, Iron, Dietary, Cohort study
Abstract

Background: Evidence from prospective studies on intake of meat and fish and risk of squamous cell carcinoma (SCC) of the upper aero-digestive tract (UADT) is scarce. We prospectively investigated the association of meat and fish intake with risk of SCC of the UADT and the possible mechanism via heme iron in the large multicenter European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Multivariable proportional hazards models were used to estimate relative risks (RR) of SCC of the UADT in relation to intake of total meat, as well as subtypes of meat, fish, and heme iron among 348,738 individuals from 7 European countries. Results: During an average follow-up of 11.8 years, a total of 682 incident cases of UADT SCC were accrued. Intake of processed meat was positively associated with risk of SCC of the UADT in the total cohort [highest vs. lowest quintile: RR = 1.41; 95% confidence interval (CI) = 1.03–1.94], however, in stratified analyses, this association was confined to the group of current smokers (highest vs. lowest quintile: RR = 1.89; 95% CI = 1.22–2.93). Red meat, poultry, fish, and heme iron were not consistently related to UADT SCC. Conclusion: Higher intake of processed meat was positively associated with SCC of the UADT among smokers. Although this finding was stable in various sensitivity analyses, we cannot rule out residual confounding by smoking. Confirmation in future studies and identification of biologic mechanisms is warranted. Impact: Smokers may further increase their risk for SCC of the UADT if they additionally consume large amounts of processed meat. Cancer Epidemiol Biomarkers Prev; 21(12); 2138–48. ©2012 AACR.

Published
2012
Full Text
View/download PDF

42. Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

Author

Bo Hedblad, Y. T. van der Schouw, Rikke Egeberg, Rudolf Kaaks, Conchi Moreno-Iribas, Timothy J. Key, J. R. Quirós, Pamela Ferrari, M-J Sanchez, S-C Chuang, Sabina Sieri, H. B. Bueno-de-Mesquita, José María Huerta, Anne Tjønneland, V Ouranos, Miren Dorronsoro, Francesca L. Crowe, Teresa Norat, J.M.A. Boer, Elio Riboli, Heiner Boeing, Elisavet Valanou, Giuseppe Matullo, Genevieve Buckland, Nicholas J. Wareham, K-T Khaw, Joline W.J. Beulens, Kim Overvad, Giovanna Masala, B Teucher, A-K Illner, Salvatore Panico, John Danesh, Erik Berg Schmidt, Rosario Tumino, P N Appleby, J. H. Jansson, Patrik Wennberg, Antonia Trichopoulou, Cornelia Weikert, Crowe, Fl, Key, Tj, Appleby, Pn, Overvad, K, Schmidt, Eb, Egeberg, R, Tj?nneland, A, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Trichopoulou, A, Ouranos, V, Valanou, E, Masala, G, Sieri, S, Panico, Salvatore, Tumino, R, Matullo, G, Bueno de Mesquita, Hb, Boer, Jm, Beulens, Jw, van der Schouw, Yt, Quir?s, Jr, Buckland, G, S?nchez, Mj, Dorronsoro, M, Huerta, Jm, Moreno Iribas, C, Hedblad, B, Jansson, Jh, Wennberg, P, Khaw, Kt, Wareham, N, Ferrari, P, Illner, Ak, Chuang, Sc, Norat, T, Danesh, J, Riboli, E., Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, and APH - Health Behaviors & Chronic Diseases

Subjects
Dietary Fiber, Male, medicine.medical_specialty, Myocardial Ischemia, Medicine (miscellaneous), Nutritional Status, Disease, prospective cohort studies, Lower risk, Body Mass Index, ischaemic heart disease, Risk Factors, Internal medicine, Neoplasms, Surveys and Questionnaires, Vegetables, medicine, Humans, cardiovascular diseases, Prospective Studies, Prospective cohort study, Life Style, Nutrition and Dietetics, business.industry, dietary fibre, Dietary fibre, Middle Aged, Confidence interval, European Prospective Investigation into Cancer and Nutrition, Surgery, Diet, Europe, Relative risk, Fruit, Regression Analysis, Female, business, Edible Grain, Body mass index, Follow-Up Studies
Abstract

Background/objectives:Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.Subjects/methods:Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.Results:After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).Conclusion:A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.European Journal of Clinical Nutrition advance online publication, 23 May 2012; doi:10.1038/ejcn.2012.51.

Published
2012
Full Text
View/download PDF

43. The combined impact of adherence to five lifestyle factors on all-cause, cancer and cardiovascular mortality: a prospective cohort study among Danish men and women.

Author

Petersen KE, Johnsen NF, Olsen A, Albieri V, Olsen LK, Dragsted LO, Overvad K, Tjønneland A, and Egeberg R

Subjects
Alcohol Abstinence, Alcohol Drinking adverse effects, Cardiovascular Diseases etiology, Cardiovascular Diseases mortality, Cardiovascular Diseases therapy, Cohort Studies, Combined Modality Therapy, Denmark epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality, Motor Activity, Neoplasms etiology, Neoplasms mortality, Neoplasms therapy, Overweight physiopathology, Overweight prevention & control, Overweight therapy, Prospective Studies, Smoking Cessation, Waist Circumference, Weight Loss, Cardiovascular Diseases prevention & control, Health Promotion, Life Style, Neoplasms prevention & control, Nutrition Policy, Patient Compliance
Abstract

Individual lifestyle factors have been associated with lifestyle diseases and premature mortality by an accumulating body of evidence. The impact of a combination of lifestyle factors on mortality has been investigated in several studies, but few have applied a simple index taking national guidelines into account. The objective of the present prospective cohort study was to investigate the combined impact of adherence to five lifestyle factors (smoking, alcohol intake, physical activity, waist circumference and diet) on all-cause, cancer and cardiovascular mortality based on international and national health recommendations. A Cox proportional hazards model was used to estimate hazard ratios (HR) with 95 % CI. During a median follow-up of 14 years, 3941 men and 2827 women died. Among men, adherence to one additional health recommendation was associated with an adjusted HR of 0·73 (95 % CI 0·71, 0·75) for all-cause mortality, 0·74 (95 % CI 0·71, 0·78) for cancer mortality and 0·70 (95 % CI 0·65, 0·75) for cardiovascular mortality. Among women, the corresponding HR was 0·72 (95 % CI 0·70, 0·75) for all-cause mortality, 0·76 (95 % CI 0·73, 0·80) for cancer mortality and 0·63 (95 % CI 0·57, 0·70) for cardiovascular mortality. In the present study, adherence to merely one additional health recommendation had a protective effect on mortality risk, indicating a huge potential in enhancing healthy lifestyle behaviours of the population.

Published
2015
Full Text
View/download PDF

44. Associations between red meat and risks for colon and rectal cancer depend on the type of red meat consumed.

Author

Egeberg R, Olsen A, Christensen J, Halkjær J, Jakobsen MU, Overvad K, and Tjønneland A

Subjects
Animals, Cattle, Cohort Studies, Colonic Neoplasms etiology, Female, Fishes, Follow-Up Studies, Humans, Male, Meat Products, Middle Aged, Poultry, Proportional Hazards Models, Prospective Studies, Rectal Neoplasms etiology, Risk Factors, Sheep, Swine, Colonic Neoplasms epidemiology, Meat adverse effects, Rectal Neoplasms epidemiology
Abstract

Cancer prevention guidelines recommend limiting intake of red meat and avoiding processed meat; however, few studies have been conducted on the effects of specific red meat subtypes on colon cancer or rectal cancer risk. The study aim was to evaluate associations between intake of red meat and its subtypes, processed meat, fish, and poultry and risk for colon cancer or rectal cancer in the Danish Diet, Cancer and Health cohort study. We also evaluated whether fish or poultry should replace red meat intake to prevent colon cancer or rectal cancer. During follow-up (13.4 y), 644 cases of colon cancer and 345 cases of rectal cancer occurred among 53,988 participants. Cox proportional hazards models were used to compute incidence rate ratio (IRRs) and 95% CIs. No associations were found between intake of red meat, processed meat, fish, or poultry and risk for colon cancer or rectal cancer. The risk associated with specific red meat subtypes depended on the animal of origin and cancer subsite; thus, the risk for colon cancer was significantly elevated for higher intake of lamb [IRR(per 5g/d) = 1.07 (95% CI: 1.02-1.13)], whereas the risk for rectal cancer was elevated for higher intake of pork [IRR(per 25g/d) = 1.18 (95% CI: 1.02-1.36)]. Substitution of fish for red meat was associated with a significantly lower risk for colon cancer [IRR(per 25g/d) = 0.89 (95% CI: 0.80-0.99)] but not rectal cancer. Substitution of poultry for red meat did not reduce either risk. This study suggests that the risks for colon cancer and potentially for rectal cancer differ according to the specific red meat subtype consumed.

Published
2013
Full Text
View/download PDF

45. Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition.

Author

Rohrmann S, Overvad K, Bueno-de-Mesquita HB, Jakobsen MU, Egeberg R, Tjønneland A, Nailler L, Boutron-Ruault MC, Clavel-Chapelon F, Krogh V, Palli D, Panico S, Tumino R, Ricceri F, Bergmann MM, Boeing H, Li K, Kaaks R, Khaw KT, Wareham NJ, Crowe FL, Key TJ, Naska A, Trichopoulou A, Trichopoulos D, Leenders M, Peeters PH, Engeset D, Parr CL, Skeie G, Jakszyn P, Sánchez MJ, Huerta JM, Redondo ML, Barricarte A, Amiano P, Drake I, Sonestedt E, Hallmans G, Johansson I, Fedirko V, Romieux I, Ferrari P, Norat T, Vergnaud AC, Riboli E, and Linseisen J

Subjects
Adult, Aged, Cardiovascular Diseases epidemiology, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasms epidemiology, Nutrition Surveys, Prospective Studies, Survival Analysis, United States, Cardiovascular Diseases mortality, Diet adverse effects, Feeding Behavior, Meat, Neoplasms mortality
Abstract

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)., Methods: Included in the analysis were 448,568 men and women without prevalent cancer, stroke, or myocardial infarction, and with complete information on diet, smoking, physical activity and body mass index, who were between 35 and 69 years old at baseline. Cox proportional hazards regression was used to examine the association of meat consumption with all-cause and cause-specific mortality., Results: As of June 2009, 26,344 deaths were observed. After multivariate adjustment, a high consumption of red meat was related to higher all-cause mortality (hazard ratio (HR) = 1.14, 95% confidence interval (CI) 1.01 to 1.28, 160+ versus 10 to 19.9 g/day), and the association was stronger for processed meat (HR = 1.44, 95% CI 1.24 to 1.66, 160+ versus 10 to 19.9 g/day). After correction for measurement error, higher all-cause mortality remained significant only for processed meat (HR = 1.18, 95% CI 1.11 to 1.25, per 50 g/d). We estimated that 3.3% (95% CI 1.5% to 5.0%) of deaths could be prevented if all participants had a processed meat consumption of less than 20 g/day. Significant associations with processed meat intake were observed for cardiovascular diseases, cancer, and 'other causes of death'. The consumption of poultry was not related to all-cause mortality., Conclusions: The results of our analysis support a moderate positive association between processed meat consumption and mortality, in particular due to cardiovascular diseases, but also to cancer.

Published
2013
Full Text
View/download PDF

46. Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition.

Author

Rohrmann S, Linseisen J, Nöthlings U, Overvad K, Egeberg R, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Cottet V, Pala V, Tumino R, Palli D, Panico S, Vineis P, Boeing H, Pischon T, Grote V, Teucher B, Khaw KT, Wareham NJ, Crowe FL, Goufa I, Orfanos P, Trichopoulou A, Jeurnink SM, Siersema PD, Peeters PH, Brustad M, Engeset D, Skeie G, Duell EJ, Amiano P, Barricarte A, Molina-Montes E, Rodríguez L, Tormo MJ, Sund M, Ye W, Lindkvist B, Johansen D, Ferrari P, Jenab M, Slimani N, Ward H, Riboli E, Norat T, and Bueno-de-Mesquita HB

Subjects
Animals, Cohort Studies, Diet, Female, Fishes, Humans, Life Style, Male, Middle Aged, Nutritional Status, Poultry, Prospective Studies, Risk Assessment, Risk Factors, Feeding Behavior, Fish Products, Meat, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms etiology
Abstract

Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI = 0.93-1.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI = 0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day = 1.72, 95% CI = 1.04-2.84); however, there was no association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI = 0.92-1.62). Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings., (Copyright © 2012 UICC.)

Published
2013
Full Text
View/download PDF

47. Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study.

Author

Bendinelli B, Palli D, Masala G, Sharp SJ, Schulze MB, Guevara M, van der AD, Sera F, Amiano P, Balkau B, Barricarte A, Boeing H, Crowe FL, Dahm CC, Dalmeijer G, de Lauzon-Guillain B, Egeberg R, Fagherazzi G, Franks PW, Krogh V, Huerta JM, Jakszyn P, Khaw KT, Li K, Mattiello A, Nilsson PM, Overvad K, Ricceri F, Rolandsson O, Sánchez MJ, Slimani N, Sluijs I, Spijkerman AM, Teucher B, Tjonneland A, Tumino R, van den Berg SW, Forouhi NG, Langeberg C, Feskens EJ, Riboli E, and Wareham NJ

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 ethnology, Diet ethnology, Europe epidemiology, Female, Follow-Up Studies, Humans, Incidence, Iron, Dietary administration & dosage, Iron, Dietary adverse effects, Male, Meat analysis, Meat Products adverse effects, Meat Products analysis, Middle Aged, Prospective Studies, Risk, Sex Characteristics, Young Adult, Diabetes Mellitus, Type 2 etiology, Diet adverse effects, Meat adverse effects
Abstract

Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study., Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption., Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants., Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

Published
2013
Full Text
View/download PDF

48. Meat and heme iron intake and risk of squamous cell carcinoma of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author

Steffen A, Bergmann MM, Sánchez MJ, Chirlaque MD, Jakszyn P, Amiano P, Quirós JR, Barricarte Gurrea A, Ferrari P, Romieu I, Fedirko V, Bueno-de-Mesquita HB, Siersema PD, Peeters PH, Khaw KT, Wareham N, Allen NE, Crowe FL, Skeie G, Hallmanns G, Johansson I, Borgquist S, Ericson U, Egeberg R, Tjønneland A, Overvad K, Grote V, Li K, Trichopoulou A, Oikonomidou D, Pantzalis M, Tumino R, Panico S, Palli D, Krogh V, Naccarati A, Mouw T, Vergnaud AC, Norat T, and Boeing H

Subjects
Carcinoma, Squamous Cell etiology, Cohort Studies, Europe epidemiology, Feeding Behavior, Female, Heme adverse effects, Humans, Iron, Dietary adverse effects, Laryngeal Neoplasms etiology, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk, Risk Assessment, Carcinoma, Squamous Cell epidemiology, Heme administration & dosage, Iron, Dietary administration & dosage, Laryngeal Neoplasms epidemiology, Meat
Abstract

Background: Evidence from prospective studies on intake of meat and fish and risk of squamous cell carcinoma (SCC) of the upper aero-digestive tract (UADT) is scarce. We prospectively investigated the association of meat and fish intake with risk of SCC of the UADT and the possible mechanism via heme iron in the large multicenter European Prospective Investigation into Cancer and Nutrition (EPIC) study., Methods: Multivariable proportional hazards models were used to estimate relative risks (RR) of SCC of the UADT in relation to intake of total meat, as well as subtypes of meat, fish, and heme iron among 348,738 individuals from 7 European countries., Results: During an average follow-up of 11.8 years, a total of 682 incident cases of UADT SCC were accrued. Intake of processed meat was positively associated with risk of SCC of the UADT in the total cohort [highest vs. lowest quintile: RR = 1.41; 95% confidence interval (CI) = 1.03-1.94], however, in stratified analyses, this association was confined to the group of current smokers (highest vs. lowest quintile: RR = 1.89; 95% CI = 1.22-2.93). Red meat, poultry, fish, and heme iron were not consistently related to UADT SCC., Conclusion: Higher intake of processed meat was positively associated with SCC of the UADT among smokers. Although this finding was stable in various sensitivity analyses, we cannot rule out residual confounding by smoking. Confirmation in future studies and identification of biologic mechanisms is warranted., Impact: Smokers may further increase their risk for SCC of the UADT if they additionally consume large amounts of processed meat.

Published
2012
Full Text
View/download PDF

49. Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort.

Author

Hansen L, Skeie G, Landberg R, Lund E, Palmqvist R, Johansson I, Dragsted LO, Egeberg R, Johnsen NF, Christensen J, Overvad K, Tjønneland A, and Olsen A

Subjects
Adult, Cohort Studies, Colonic Neoplasms etiology, Colonic Neoplasms prevention & control, Eating, Feeding Behavior, Female, Fruit, Humans, Incidence, Male, Middle Aged, Rectal Neoplasms epidemiology, Risk Factors, Scandinavian and Nordic Countries epidemiology, Vegetables, Colonic Neoplasms epidemiology, Dietary Fiber administration & dosage, Edible Grain
Abstract

The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer., (Copyright © 2011 UICC.)

Published
2012
Full Text
View/download PDF

50. Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study.

Author

Andersen V, Egeberg R, Tjønneland A, and Vogel U

Subjects
Cohort Studies, Colorectal Neoplasms epidemiology, Colorectal Neoplasms genetics, Denmark epidemiology, Female, Gene-Environment Interaction, Genotype, Humans, Incidence, Life Style, Male, Middle Aged, Risk, Surveys and Questionnaires, Colorectal Neoplasms etiology, Dietary Fiber, Interleukin-10 genetics, Polymorphism, Single Nucleotide, White People
Abstract

Background: More than 50% of the colorectal cancer (CRC) etiology has been attributed to diet. Established or suspected dietary factors modifying risk of CRC are red meat, cereals, fish, and fibre. Diet and lifestyle may be linked to cancer through inflammation. Interleukin-10 (IL-10) is an anti-inflammatory cytokine. We wanted to test if dietary factors and IL10 polymorphisms interact in relation to colorectal carcinogenesis., Methods: The functional IL10 polymorphism C-592A (rs1800872) and the marker rs3024505 were assessed in relation to diet and lifestyle in a nested case-cohort study of 378 CRC cases and 775 randomly selected participants from a prospective study of 57,053 persons. Genotyping data on the IL10 polymorphism C-592A, smoking and non-steroidal anti-inflammatory drugs (NSAID) was retrieved from Vogel et al. (Mutat Res, 2007; 624:88). Incidence rate ratios (IRR) and 95% Confidence Interval (95% CI) were calculated., Results: No associations were found between the IL10 rs3024505 polymorphism and risk of CRC. There was interaction between rs3024505 and dietary fibre (P-value for interaction = 0.01). IL10 rs3024505 homozygous wildtype carriers were at 27% reduced risk of CRC per 10 g fibre per day (95% CI: 0.60-0.88) whereas variant carriers had no risk reduction by fibre intake. Also, interaction between IL10 C-592A and intake of fibre was found (P-value for interaction = 0.02). Among those eating <17.0 grams of fibre per day, carriers of an C-592A variant allele had a statistically significantly higher risk of colorectal cancer compared to homozygous wildtypes. No significant differences in colorectal cancer risk were observed between the reference group (CC and <17.0 g/day) and carriers of one C-592A variant allele eating 17.0 or more grams of dietary fibre per day. This suggests that the increased risk due to carrying the variant allele can be overcome by higher fibre intake. No interactions between IL10 polymorphisms and dietary meat, cereal, or fish intake, or between IL10 rs3024505 and smoking or NSAID use were found., Conclusions: In this northern Caucasian cohort we found interaction between IL10 and dietary fibre in CRC carcinogenesis. High intake of fibre seems to protect against CRC among individuals with IL10 related genetic susceptibility to CRC. This finding should be evaluated in other prospective and population-based cohorts with different ethnic groups.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results